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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:SPTLC2-DIAPH3 (FusionGDB2 ID:86168)

Fusion Gene Summary for SPTLC2-DIAPH3

Fusion gene summary

Fusion gene information	Fusion gene name: SPTLC2-DIAPH3
	Fusion gene ID: 86168
		Hgene	Tgene
	Gene symbol	SPTLC2	DIAPH3
	Gene ID	9517	81624
	Gene name	serine palmitoyltransferase long chain base subunit 2	diaphanous related formin 3
	Synonyms	HSN1C\|LCB2\|LCB2A\|NSAN1C\|SPT2\|hLCB2a	AN\|AUNA1\|DIA2\|DRF3\|NSDAN\|diap3\|mDia2
	Cytomap	14q24.3	13q21.2
	Type of gene	protein-coding	protein-coding
	Description	serine palmitoyltransferase 2LCB 2SPT 2long chain base biosynthesis protein 2aserine palmitoyltransferase, subunit IIserine-palmitoyl-CoA transferase 2	protein diaphanous homolog 3diaphanous homolog 3
	Modification date	20200313	20200313
	UniProtAcc	.	Q9NSV4
	Ensembl transtripts involved in fusion gene	ENST00000216484, ENST00000556264,	ENST00000465066, ENST00000267215, ENST00000377908, ENST00000400319, ENST00000400320, ENST00000400324, ENST00000400330,
Fusion gene scores	* DoF score	9 X 10 X 5=450	20 X 18 X 9=3240
	# samples	11	23
	** MAII score	log2(11/450*10)=-2.03242147769238 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(23/3240*10)=-3.81628804682761 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SPTLC2 [Title/Abstract] AND DIAPH3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SPTLC2(78043110)-DIAPH3(60348957), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SPTLC2	GO:0030148	sphingolipid biosynthetic process	25332431\|26573920
Hgene	SPTLC2	GO:0046513	ceramide biosynthetic process	25691431
Hgene	SPTLC2	GO:1904504	positive regulation of lipophagy	25332431

Fusion gene breakpoints across SPTLC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DIAPH3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-IN-AB1X-01A	SPTLC2	chr14	78043110	-	DIAPH3	chr13	60348957	-
ChimerDB4	STAD	TCGA-IN-AB1X	SPTLC2	chr14	78043109	-	DIAPH3	chr13	60348957	-

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Fusion Gene ORF analysis for SPTLC2-DIAPH3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000216484	ENST00000465066	SPTLC2	chr14	78043110	-	DIAPH3	chr13	60348957	-
5CDS-5UTR	ENST00000216484	ENST00000465066	SPTLC2	chr14	78043109	-	DIAPH3	chr13	60348957	-
In-frame	ENST00000216484	ENST00000267215	SPTLC2	chr14	78043110	-	DIAPH3	chr13	60348957	-
In-frame	ENST00000216484	ENST00000267215	SPTLC2	chr14	78043109	-	DIAPH3	chr13	60348957	-
In-frame	ENST00000216484	ENST00000377908	SPTLC2	chr14	78043110	-	DIAPH3	chr13	60348957	-
In-frame	ENST00000216484	ENST00000377908	SPTLC2	chr14	78043109	-	DIAPH3	chr13	60348957	-
In-frame	ENST00000216484	ENST00000400319	SPTLC2	chr14	78043110	-	DIAPH3	chr13	60348957	-
In-frame	ENST00000216484	ENST00000400319	SPTLC2	chr14	78043109	-	DIAPH3	chr13	60348957	-
In-frame	ENST00000216484	ENST00000400320	SPTLC2	chr14	78043110	-	DIAPH3	chr13	60348957	-
In-frame	ENST00000216484	ENST00000400320	SPTLC2	chr14	78043109	-	DIAPH3	chr13	60348957	-
In-frame	ENST00000216484	ENST00000400324	SPTLC2	chr14	78043110	-	DIAPH3	chr13	60348957	-
In-frame	ENST00000216484	ENST00000400324	SPTLC2	chr14	78043109	-	DIAPH3	chr13	60348957	-
In-frame	ENST00000216484	ENST00000400330	SPTLC2	chr14	78043110	-	DIAPH3	chr13	60348957	-
In-frame	ENST00000216484	ENST00000400330	SPTLC2	chr14	78043109	-	DIAPH3	chr13	60348957	-
intron-3CDS	ENST00000556264	ENST00000267215	SPTLC2	chr14	78043110	-	DIAPH3	chr13	60348957	-
intron-3CDS	ENST00000556264	ENST00000267215	SPTLC2	chr14	78043109	-	DIAPH3	chr13	60348957	-
intron-3CDS	ENST00000556264	ENST00000377908	SPTLC2	chr14	78043110	-	DIAPH3	chr13	60348957	-
intron-3CDS	ENST00000556264	ENST00000377908	SPTLC2	chr14	78043109	-	DIAPH3	chr13	60348957	-
intron-3CDS	ENST00000556264	ENST00000400319	SPTLC2	chr14	78043110	-	DIAPH3	chr13	60348957	-
intron-3CDS	ENST00000556264	ENST00000400319	SPTLC2	chr14	78043109	-	DIAPH3	chr13	60348957	-
intron-3CDS	ENST00000556264	ENST00000400320	SPTLC2	chr14	78043110	-	DIAPH3	chr13	60348957	-
intron-3CDS	ENST00000556264	ENST00000400320	SPTLC2	chr14	78043109	-	DIAPH3	chr13	60348957	-
intron-3CDS	ENST00000556264	ENST00000400324	SPTLC2	chr14	78043110	-	DIAPH3	chr13	60348957	-
intron-3CDS	ENST00000556264	ENST00000400324	SPTLC2	chr14	78043109	-	DIAPH3	chr13	60348957	-
intron-3CDS	ENST00000556264	ENST00000400330	SPTLC2	chr14	78043110	-	DIAPH3	chr13	60348957	-
intron-3CDS	ENST00000556264	ENST00000400330	SPTLC2	chr14	78043109	-	DIAPH3	chr13	60348957	-
intron-5UTR	ENST00000556264	ENST00000465066	SPTLC2	chr14	78043110	-	DIAPH3	chr13	60348957	-
intron-5UTR	ENST00000556264	ENST00000465066	SPTLC2	chr14	78043109	-	DIAPH3	chr13	60348957	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000216484	SPTLC2	chr14	78043110	-	ENST00000400324	DIAPH3	chr13	60348957	-	2245	825	68	1243	391
ENST00000216484	SPTLC2	chr14	78043110	-	ENST00000400330	DIAPH3	chr13	60348957	-	2237	825	68	1243	391
ENST00000216484	SPTLC2	chr14	78043110	-	ENST00000400319	DIAPH3	chr13	60348957	-	1244	825	68	1243	392
ENST00000216484	SPTLC2	chr14	78043110	-	ENST00000400320	DIAPH3	chr13	60348957	-	1244	825	68	1243	392
ENST00000216484	SPTLC2	chr14	78043110	-	ENST00000377908	DIAPH3	chr13	60348957	-	1244	825	68	1243	392
ENST00000216484	SPTLC2	chr14	78043110	-	ENST00000267215	DIAPH3	chr13	60348957	-	1111	825	68	1000	310
ENST00000216484	SPTLC2	chr14	78043109	-	ENST00000400324	DIAPH3	chr13	60348957	-	2245	825	68	1243	391
ENST00000216484	SPTLC2	chr14	78043109	-	ENST00000400330	DIAPH3	chr13	60348957	-	2237	825	68	1243	391
ENST00000216484	SPTLC2	chr14	78043109	-	ENST00000400319	DIAPH3	chr13	60348957	-	1244	825	68	1243	392
ENST00000216484	SPTLC2	chr14	78043109	-	ENST00000400320	DIAPH3	chr13	60348957	-	1244	825	68	1243	392
ENST00000216484	SPTLC2	chr14	78043109	-	ENST00000377908	DIAPH3	chr13	60348957	-	1244	825	68	1243	392
ENST00000216484	SPTLC2	chr14	78043109	-	ENST00000267215	DIAPH3	chr13	60348957	-	1111	825	68	1000	310

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000216484	ENST00000400324	SPTLC2	chr14	78043110	-	DIAPH3	chr13	60348957	-	0.000121169	0.99987876
ENST00000216484	ENST00000400330	SPTLC2	chr14	78043110	-	DIAPH3	chr13	60348957	-	0.000121038	0.999879
ENST00000216484	ENST00000400319	SPTLC2	chr14	78043110	-	DIAPH3	chr13	60348957	-	0.000489815	0.99951017
ENST00000216484	ENST00000400320	SPTLC2	chr14	78043110	-	DIAPH3	chr13	60348957	-	0.000489815	0.99951017
ENST00000216484	ENST00000377908	SPTLC2	chr14	78043110	-	DIAPH3	chr13	60348957	-	0.000489815	0.99951017
ENST00000216484	ENST00000267215	SPTLC2	chr14	78043110	-	DIAPH3	chr13	60348957	-	0.000524572	0.9994754
ENST00000216484	ENST00000400324	SPTLC2	chr14	78043109	-	DIAPH3	chr13	60348957	-	0.000121169	0.99987876
ENST00000216484	ENST00000400330	SPTLC2	chr14	78043109	-	DIAPH3	chr13	60348957	-	0.000121038	0.999879
ENST00000216484	ENST00000400319	SPTLC2	chr14	78043109	-	DIAPH3	chr13	60348957	-	0.000489815	0.99951017
ENST00000216484	ENST00000400320	SPTLC2	chr14	78043109	-	DIAPH3	chr13	60348957	-	0.000489815	0.99951017
ENST00000216484	ENST00000377908	SPTLC2	chr14	78043109	-	DIAPH3	chr13	60348957	-	0.000489815	0.99951017
ENST00000216484	ENST00000267215	SPTLC2	chr14	78043109	-	DIAPH3	chr13	60348957	-	0.000524572	0.9994754

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Fusion Genomic Features for SPTLC2-DIAPH3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SPTLC2-DIAPH3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:78043110/chr13:60348957)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	DIAPH3 Q9NSV4
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Actin nucleation and elongation factor required for the assembly of F-actin structures, such as actin cables and stress fibers. Required for cytokinesis, stress fiber formation and transcriptional activation of the serum response factor. Binds to GTP-bound form of Rho and to profilin: acts in a Rho-dependent manner to recruit profilin to the membrane, where it promotes actin polymerization. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Also acts as an actin nucleation and elongation factor in the nucleus by promoting nuclear actin polymerization inside the nucleus to drive serum-dependent SRF-MRTFA activity. {ECO:0000250\|UniProtKB:Q9Z207}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SPTLC2

chr14:78043109

chr13:60348957

ENST00000216484

67_87

210

563.0

Transmembrane

Helical

Hgene

SPTLC2

chr14:78043110

chr13:60348957

ENST00000216484

67_87

210

563.0

Transmembrane

Helical

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400319

1013_1056

984

1124.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400320

1013_1056

1008

1148.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400319

1013_1056

984

1124.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400320

1013_1056

1008

1148.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000267215

1057_1087

1054

1113.0

Domain

DAD

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000377908

1057_1087

1043

1183.0

Domain

DAD

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400319

1057_1087

984

1124.0

Domain

DAD

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400320

1057_1087

1008

1148.0

Domain

DAD

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400324

1057_1087

1054

1194.0

Domain

DAD

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000267215

1057_1087

1054

1113.0

Domain

DAD

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000377908

1057_1087

1043

1183.0

Domain

DAD

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400319

1057_1087

984

1124.0

Domain

DAD

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400320

1057_1087

1008

1148.0

Domain

DAD

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400324

1057_1087

1054

1194.0

Domain

DAD

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000267215

1184_1193

1054

1113.0

Motif

Nuclear export signal

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000377908

1184_1193

1043

1183.0

Motif

Nuclear export signal

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400319

1184_1193

984

1124.0

Motif

Nuclear export signal

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400320

1184_1193

1008

1148.0

Motif

Nuclear export signal

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400324

1184_1193

1054

1194.0

Motif

Nuclear export signal

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000267215

1184_1193

1054

1113.0

Motif

Nuclear export signal

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000377908

1184_1193

1043

1183.0

Motif

Nuclear export signal

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400319

1184_1193

984

1124.0

Motif

Nuclear export signal

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400320

1184_1193

1008

1148.0

Motif

Nuclear export signal

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400324

1184_1193

1054

1194.0

Motif

Nuclear export signal

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000267215

1013_1056

1054

1113.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000267215

497_554

1054

1113.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000377908

1013_1056

1043

1183.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000377908

497_554

1043

1183.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400319

497_554

984

1124.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400320

497_554

1008

1148.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400324

1013_1056

1054

1194.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400324

497_554

1054

1194.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000267215

1013_1056

1054

1113.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000267215

497_554

1054

1113.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000377908

1013_1056

1043

1183.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000377908

497_554

1043

1183.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400319

497_554

984

1124.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400320

497_554

1008

1148.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400324

1013_1056

1054

1194.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400324

497_554

1054

1194.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000267215

561_636

1054

1113.0

Compositional bias

Note=Pro-rich

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000377908

561_636

1043

1183.0

Compositional bias

Note=Pro-rich

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400319

561_636

984

1124.0

Compositional bias

Note=Pro-rich

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400320

561_636

1008

1148.0

Compositional bias

Note=Pro-rich

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400324

561_636

1054

1194.0

Compositional bias

Note=Pro-rich

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000267215

561_636

1054

1113.0

Compositional bias

Note=Pro-rich

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000377908

561_636

1043

1183.0

Compositional bias

Note=Pro-rich

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400319

561_636

984

1124.0

Compositional bias

Note=Pro-rich

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400320

561_636

1008

1148.0

Compositional bias

Note=Pro-rich

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400324

561_636

1054

1194.0

Compositional bias

Note=Pro-rich

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000267215

114_476

1054

1113.0

Domain

GBD/FH3

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000267215

561_631

1054

1113.0

Domain

Note=FH1

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000267215

636_1034

1054

1113.0

Domain

FH2

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000377908

114_476

1043

1183.0

Domain

GBD/FH3

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000377908

561_631

1043

1183.0

Domain

Note=FH1

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000377908

636_1034

1043

1183.0

Domain

FH2

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400319

114_476

984

1124.0

Domain

GBD/FH3

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400319

561_631

984

1124.0

Domain

Note=FH1

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400319

636_1034

984

1124.0

Domain

FH2

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400320

114_476

1008

1148.0

Domain

GBD/FH3

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400320

561_631

1008

1148.0

Domain

Note=FH1

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400320

636_1034

1008

1148.0

Domain

FH2

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400324

114_476

1054

1194.0

Domain

GBD/FH3

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400324

561_631

1054

1194.0

Domain

Note=FH1

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400324

636_1034

1054

1194.0

Domain

FH2

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000267215

114_476

1054

1113.0

Domain

GBD/FH3

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000267215

561_631

1054

1113.0

Domain

Note=FH1

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000267215

636_1034

1054

1113.0

Domain

FH2

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000377908

114_476

1043

1183.0

Domain

GBD/FH3

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000377908

561_631

1043

1183.0

Domain

Note=FH1

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000377908

636_1034

1043

1183.0

Domain

FH2

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400319

114_476

984

1124.0

Domain

GBD/FH3

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400319

561_631

984

1124.0

Domain

Note=FH1

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400319

636_1034

984

1124.0

Domain

FH2

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400320

114_476

1008

1148.0

Domain

GBD/FH3

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400320

561_631

1008

1148.0

Domain

Note=FH1

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400320

636_1034

1008

1148.0

Domain

FH2

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400324

114_476

1054

1194.0

Domain

GBD/FH3

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400324

561_631

1054

1194.0

Domain

Note=FH1

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400324

636_1034

1054

1194.0

Domain

FH2

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000267215

36_60

1054

1113.0

Motif

Nuclear localization signal

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000377908

36_60

1043

1183.0

Motif

Nuclear localization signal

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400319

36_60

984

1124.0

Motif

Nuclear localization signal

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400320

36_60

1008

1148.0

Motif

Nuclear localization signal

Tgene

DIAPH3

chr14:78043109

chr13:60348957

ENST00000400324

36_60

1054

1194.0

Motif

Nuclear localization signal

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000267215

36_60

1054

1113.0

Motif

Nuclear localization signal

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000377908

36_60

1043

1183.0

Motif

Nuclear localization signal

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400319

36_60

984

1124.0

Motif

Nuclear localization signal

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400320

36_60

1008

1148.0

Motif

Nuclear localization signal

Tgene

DIAPH3

chr14:78043110

chr13:60348957

ENST00000400324

36_60

1054

1194.0

Motif

Nuclear localization signal

Top

Fusion Gene Sequence for SPTLC2-DIAPH3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>86168_86168_1_SPTLC2-DIAPH3_SPTLC2_chr14_78043109_ENST00000216484_DIAPH3_chr13_60348957_ENST00000267215_length(transcript)=1111nt_BP=825nt
GCGTGGCCTTGGCCGAGACCGGTCCTCTGCGGAGAGGGCCCCGCCCTCTGTGAAGGCCCGCCCGGGAATTGGCGGCGGCGCTGCAGCCAT
TTCCGGTTTCGGGGAGGTGGGTGGGGTGCGGAGCGGGACTTGGAGCAGCCGCCGCCGCTGCCACCGCCTACAGAGCCTGCCTTGCGCCTG
GTGCTGCCAGGAAGATGCGGCCGGAGCCCGGAGGCTGCTGCTGCCGCCGCACGGTGCGGGCGAATGGCTGCGTGGCGAACGGGGAAGTAC
GGAACGGGTACGTGAGGAGCAGCGCTGCAGCCGCAGCCGCAGCCGCCGCCGGCCAGATCCATCATGTTACACAAAATGGAGGACTATATA
AAAGACCGTTTAATGAAGCTTTTGAAGAAACACCAATGCTGGTTGCTGTGCTCACGTATGTGGGGTATGGCGTACTCACCCTCTTTGGAT
ATCTTCGAGATTTCTTGAGGTATTGGAGAATTGAAAAGTGTCACCATGCAACAGAAAGAGAAGAACAAAAGGACTTTGTGTCATTGTATC
AAGATTTTGAAAACTTTTATACAAGGAATCTGTACATGAGGATAAGAGACAACTGGAATCGGCCAATCTGTAGTGTGCCTGGAGCCAGGG
TGGACATCATGGAGAGACAGTCTCATGATTATAACTGGTCCTTCAAGTATACAGGGAATATAATAAAGGGTGTTATAAACATGGGTTCCT
ACAACTATCTTGGATTTGCACGGAATACTGGATCATGTCAAGAAGCAGCCGCCAAAGTCCTTGAGGAGTATGGAGCTGGAGTGTGCAGTA
CTCGGCAGGAAATTGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAA
AAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGGTAATAAAC
CGTATTTATAAATTGCACATTCTTCTTATCTACTTTTATCCTATTGATCTGTGATTTTAGTAGACTGCTGTGAAATTCTCAAGTTCCAAT

>86168_86168_1_SPTLC2-DIAPH3_SPTLC2_chr14_78043109_ENST00000216484_DIAPH3_chr13_60348957_ENST00000267215_length(amino acids)=310AA_BP=252
MAAALQPFPVSGRWVGCGAGLGAAAAAATAYRACLAPGAARKMRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHV
TQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPI
CSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIEGDETGVMDNLLEALQSG

--------------------------------------------------------------
>86168_86168_2_SPTLC2-DIAPH3_SPTLC2_chr14_78043109_ENST00000216484_DIAPH3_chr13_60348957_ENST00000377908_length(transcript)=1244nt_BP=825nt
GCGTGGCCTTGGCCGAGACCGGTCCTCTGCGGAGAGGGCCCCGCCCTCTGTGAAGGCCCGCCCGGGAATTGGCGGCGGCGCTGCAGCCAT
TTCCGGTTTCGGGGAGGTGGGTGGGGTGCGGAGCGGGACTTGGAGCAGCCGCCGCCGCTGCCACCGCCTACAGAGCCTGCCTTGCGCCTG
GTGCTGCCAGGAAGATGCGGCCGGAGCCCGGAGGCTGCTGCTGCCGCCGCACGGTGCGGGCGAATGGCTGCGTGGCGAACGGGGAAGTAC
GGAACGGGTACGTGAGGAGCAGCGCTGCAGCCGCAGCCGCAGCCGCCGCCGGCCAGATCCATCATGTTACACAAAATGGAGGACTATATA
AAAGACCGTTTAATGAAGCTTTTGAAGAAACACCAATGCTGGTTGCTGTGCTCACGTATGTGGGGTATGGCGTACTCACCCTCTTTGGAT
ATCTTCGAGATTTCTTGAGGTATTGGAGAATTGAAAAGTGTCACCATGCAACAGAAAGAGAAGAACAAAAGGACTTTGTGTCATTGTATC
AAGATTTTGAAAACTTTTATACAAGGAATCTGTACATGAGGATAAGAGACAACTGGAATCGGCCAATCTGTAGTGTGCCTGGAGCCAGGG
TGGACATCATGGAGAGACAGTCTCATGATTATAACTGGTCCTTCAAGTATACAGGGAATATAATAAAGGGTGTTATAAACATGGGTTCCT
ACAACTATCTTGGATTTGCACGGAATACTGGATCATGTCAAGAAGCAGCCGCCAAAGTCCTTGAGGAGTATGGAGCTGGAGTGTGCAGTA
CTCGGCAGGAAATTGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAA
AAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGA
AAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATC
TAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAAC

>86168_86168_2_SPTLC2-DIAPH3_SPTLC2_chr14_78043109_ENST00000216484_DIAPH3_chr13_60348957_ENST00000377908_length(amino acids)=392AA_BP=252
MAAALQPFPVSGRWVGCGAGLGAAAAAATAYRACLAPGAARKMRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHV
TQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPI
CSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIEGDETGVMDNLLEALQSG
AAFRDRRKRTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVES

--------------------------------------------------------------
>86168_86168_3_SPTLC2-DIAPH3_SPTLC2_chr14_78043109_ENST00000216484_DIAPH3_chr13_60348957_ENST00000400319_length(transcript)=1244nt_BP=825nt
GCGTGGCCTTGGCCGAGACCGGTCCTCTGCGGAGAGGGCCCCGCCCTCTGTGAAGGCCCGCCCGGGAATTGGCGGCGGCGCTGCAGCCAT
TTCCGGTTTCGGGGAGGTGGGTGGGGTGCGGAGCGGGACTTGGAGCAGCCGCCGCCGCTGCCACCGCCTACAGAGCCTGCCTTGCGCCTG
GTGCTGCCAGGAAGATGCGGCCGGAGCCCGGAGGCTGCTGCTGCCGCCGCACGGTGCGGGCGAATGGCTGCGTGGCGAACGGGGAAGTAC
GGAACGGGTACGTGAGGAGCAGCGCTGCAGCCGCAGCCGCAGCCGCCGCCGGCCAGATCCATCATGTTACACAAAATGGAGGACTATATA
AAAGACCGTTTAATGAAGCTTTTGAAGAAACACCAATGCTGGTTGCTGTGCTCACGTATGTGGGGTATGGCGTACTCACCCTCTTTGGAT
ATCTTCGAGATTTCTTGAGGTATTGGAGAATTGAAAAGTGTCACCATGCAACAGAAAGAGAAGAACAAAAGGACTTTGTGTCATTGTATC
AAGATTTTGAAAACTTTTATACAAGGAATCTGTACATGAGGATAAGAGACAACTGGAATCGGCCAATCTGTAGTGTGCCTGGAGCCAGGG
TGGACATCATGGAGAGACAGTCTCATGATTATAACTGGTCCTTCAAGTATACAGGGAATATAATAAAGGGTGTTATAAACATGGGTTCCT
ACAACTATCTTGGATTTGCACGGAATACTGGATCATGTCAAGAAGCAGCCGCCAAAGTCCTTGAGGAGTATGGAGCTGGAGTGTGCAGTA
CTCGGCAGGAAATTGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAA
AAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGA
AAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATC
TAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAAC

>86168_86168_3_SPTLC2-DIAPH3_SPTLC2_chr14_78043109_ENST00000216484_DIAPH3_chr13_60348957_ENST00000400319_length(amino acids)=392AA_BP=252
MAAALQPFPVSGRWVGCGAGLGAAAAAATAYRACLAPGAARKMRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHV
TQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPI
CSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIEGDETGVMDNLLEALQSG
AAFRDRRKRTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVES

--------------------------------------------------------------
>86168_86168_4_SPTLC2-DIAPH3_SPTLC2_chr14_78043109_ENST00000216484_DIAPH3_chr13_60348957_ENST00000400320_length(transcript)=1244nt_BP=825nt
GCGTGGCCTTGGCCGAGACCGGTCCTCTGCGGAGAGGGCCCCGCCCTCTGTGAAGGCCCGCCCGGGAATTGGCGGCGGCGCTGCAGCCAT
TTCCGGTTTCGGGGAGGTGGGTGGGGTGCGGAGCGGGACTTGGAGCAGCCGCCGCCGCTGCCACCGCCTACAGAGCCTGCCTTGCGCCTG
GTGCTGCCAGGAAGATGCGGCCGGAGCCCGGAGGCTGCTGCTGCCGCCGCACGGTGCGGGCGAATGGCTGCGTGGCGAACGGGGAAGTAC
GGAACGGGTACGTGAGGAGCAGCGCTGCAGCCGCAGCCGCAGCCGCCGCCGGCCAGATCCATCATGTTACACAAAATGGAGGACTATATA
AAAGACCGTTTAATGAAGCTTTTGAAGAAACACCAATGCTGGTTGCTGTGCTCACGTATGTGGGGTATGGCGTACTCACCCTCTTTGGAT
ATCTTCGAGATTTCTTGAGGTATTGGAGAATTGAAAAGTGTCACCATGCAACAGAAAGAGAAGAACAAAAGGACTTTGTGTCATTGTATC
AAGATTTTGAAAACTTTTATACAAGGAATCTGTACATGAGGATAAGAGACAACTGGAATCGGCCAATCTGTAGTGTGCCTGGAGCCAGGG
TGGACATCATGGAGAGACAGTCTCATGATTATAACTGGTCCTTCAAGTATACAGGGAATATAATAAAGGGTGTTATAAACATGGGTTCCT
ACAACTATCTTGGATTTGCACGGAATACTGGATCATGTCAAGAAGCAGCCGCCAAAGTCCTTGAGGAGTATGGAGCTGGAGTGTGCAGTA
CTCGGCAGGAAATTGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAA
AAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGA
AAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATC
TAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAAC

>86168_86168_4_SPTLC2-DIAPH3_SPTLC2_chr14_78043109_ENST00000216484_DIAPH3_chr13_60348957_ENST00000400320_length(amino acids)=392AA_BP=252
MAAALQPFPVSGRWVGCGAGLGAAAAAATAYRACLAPGAARKMRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHV
TQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPI
CSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIEGDETGVMDNLLEALQSG
AAFRDRRKRTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVES

--------------------------------------------------------------
>86168_86168_5_SPTLC2-DIAPH3_SPTLC2_chr14_78043109_ENST00000216484_DIAPH3_chr13_60348957_ENST00000400324_length(transcript)=2245nt_BP=825nt
GCGTGGCCTTGGCCGAGACCGGTCCTCTGCGGAGAGGGCCCCGCCCTCTGTGAAGGCCCGCCCGGGAATTGGCGGCGGCGCTGCAGCCAT
TTCCGGTTTCGGGGAGGTGGGTGGGGTGCGGAGCGGGACTTGGAGCAGCCGCCGCCGCTGCCACCGCCTACAGAGCCTGCCTTGCGCCTG
GTGCTGCCAGGAAGATGCGGCCGGAGCCCGGAGGCTGCTGCTGCCGCCGCACGGTGCGGGCGAATGGCTGCGTGGCGAACGGGGAAGTAC
GGAACGGGTACGTGAGGAGCAGCGCTGCAGCCGCAGCCGCAGCCGCCGCCGGCCAGATCCATCATGTTACACAAAATGGAGGACTATATA
AAAGACCGTTTAATGAAGCTTTTGAAGAAACACCAATGCTGGTTGCTGTGCTCACGTATGTGGGGTATGGCGTACTCACCCTCTTTGGAT
ATCTTCGAGATTTCTTGAGGTATTGGAGAATTGAAAAGTGTCACCATGCAACAGAAAGAGAAGAACAAAAGGACTTTGTGTCATTGTATC
AAGATTTTGAAAACTTTTATACAAGGAATCTGTACATGAGGATAAGAGACAACTGGAATCGGCCAATCTGTAGTGTGCCTGGAGCCAGGG
TGGACATCATGGAGAGACAGTCTCATGATTATAACTGGTCCTTCAAGTATACAGGGAATATAATAAAGGGTGTTATAAACATGGGTTCCT
ACAACTATCTTGGATTTGCACGGAATACTGGATCATGTCAAGAAGCAGCCGCCAAAGTCCTTGAGGAGTATGGAGCTGGAGTGTGCAGTA
CTCGGCAGGAAATTGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAA
AAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGA
AAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATC
TAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAAC
TTCTTGGCTCTTTTTCTAAAAATGAATCAGTTCCCGAAGTTGAAGCCCTGCTGGCAAGATTACGAGCTTTATAAGTTAAACTGGTTTTTA
AAAAAAATGATTAAGCCAAATATAAAGCCATGCTCTAAACTATAACACTTGAAAAAATTGCTTTTATGTAAGTGACTTTATATAGTTTTA
AATTATGATATATATTAGAAAAATAAAGCTAAATATATGATTGCAATGCTTTTTCTATGTACTGGAGGTTTTGGTTTATTCAAGATTGTA
CCGGGCTTTAATCCTTTTTTTTTTTTTTTTGTCTCCTGGTATTCCTCAGTTCTTTATTTGGTGGTTAAATTATACATATTGCTTTAGAGA
GCAGGTAGGTGGCCATGTGTTCAGCAGTGTGTCCTTAAGAAAATACCATCTTTCTAAGCCACTGGAATTTTTACTTTACTATTTTTAACA
TTAATGGATGTCAGGTCATCAACCTCAAGTCTTTACATATCCATGTATATTCCATATATATTGTTTATATAGGCCCAAGTTTCTCCTTAA
TTGGGATCTATATACTACCAGCACAACATCAAAAACATGTAATTGAATACATCAGAGCTATATATGTAAGGAAATGACTGGTGACCCCAT
TATCATCATTGTTGAATTCATGTTAAGTAGACCCTCTAGGGGACCATAAGGCAATTGAGCACATAACGAAAAATGATGCAATAAGAATGT
ATGCACTCTCTTTGCCAAATGCATGTGCTTTTGTGTAACGTGGATGTAAACAGAATTGCAGTGCTGCCGAAATTCTTGATCTTGGCTAAG
AGAGTATTTTTCCCCTTGTAATTATGACTCTGAGATAAAATTGCCATTTTGAAATTTCCAAAGTAACAACTTTTTTTATTTTATGAATAA
ACTTGGGATTGCAATTTCTCTGATCTGACAATCAATAACTTTAACAAAGATCTAAATAAGTGTTTCAAGGAAAGTTTTCCTAAGCAAATG

>86168_86168_5_SPTLC2-DIAPH3_SPTLC2_chr14_78043109_ENST00000216484_DIAPH3_chr13_60348957_ENST00000400324_length(amino acids)=391AA_BP=252
MAAALQPFPVSGRWVGCGAGLGAAAAAATAYRACLAPGAARKMRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHV
TQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPI
CSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIEGDETGVMDNLLEALQSG
AAFRDRRKRTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVES

--------------------------------------------------------------
>86168_86168_6_SPTLC2-DIAPH3_SPTLC2_chr14_78043109_ENST00000216484_DIAPH3_chr13_60348957_ENST00000400330_length(transcript)=2237nt_BP=825nt
GCGTGGCCTTGGCCGAGACCGGTCCTCTGCGGAGAGGGCCCCGCCCTCTGTGAAGGCCCGCCCGGGAATTGGCGGCGGCGCTGCAGCCAT
TTCCGGTTTCGGGGAGGTGGGTGGGGTGCGGAGCGGGACTTGGAGCAGCCGCCGCCGCTGCCACCGCCTACAGAGCCTGCCTTGCGCCTG
GTGCTGCCAGGAAGATGCGGCCGGAGCCCGGAGGCTGCTGCTGCCGCCGCACGGTGCGGGCGAATGGCTGCGTGGCGAACGGGGAAGTAC
GGAACGGGTACGTGAGGAGCAGCGCTGCAGCCGCAGCCGCAGCCGCCGCCGGCCAGATCCATCATGTTACACAAAATGGAGGACTATATA
AAAGACCGTTTAATGAAGCTTTTGAAGAAACACCAATGCTGGTTGCTGTGCTCACGTATGTGGGGTATGGCGTACTCACCCTCTTTGGAT
ATCTTCGAGATTTCTTGAGGTATTGGAGAATTGAAAAGTGTCACCATGCAACAGAAAGAGAAGAACAAAAGGACTTTGTGTCATTGTATC
AAGATTTTGAAAACTTTTATACAAGGAATCTGTACATGAGGATAAGAGACAACTGGAATCGGCCAATCTGTAGTGTGCCTGGAGCCAGGG
TGGACATCATGGAGAGACAGTCTCATGATTATAACTGGTCCTTCAAGTATACAGGGAATATAATAAAGGGTGTTATAAACATGGGTTCCT
ACAACTATCTTGGATTTGCACGGAATACTGGATCATGTCAAGAAGCAGCCGCCAAAGTCCTTGAGGAGTATGGAGCTGGAGTGTGCAGTA
CTCGGCAGGAAATTGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAA
AAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGA
AAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATC
TAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAAC
TTCTTGGCTCTTTTTCTAAAAATGAATCAGTTCCCGAAGTTGAAGCCCTGCTGGCAAGATTACGAGCTTTATAAGTTAAACTGGTTTTTA
AAAAAAATGATTAAGCCAAATATAAAGCCATGCTCTAAACTATAACACTTGAAAAAATTGCTTTTATGTAAGTGACTTTATATAGTTTTA
AATTATGATATATATTAGAAAAATAAAGCTAAATATATGATTGCAATGCTTTTTCTATGTACTGGAGGTTTTGGTTTATTCAAGATTGTA
CCGGGCTTTAATCCTTTTTTTTTTTTTTTTGTCTCCTGGTATTCCTCAGTTCTTTATTTGGTGGTTAAATTATACATATTGCTTTAGAGA
GCAGGTAGGTGGCCATGTGTTCAGCAGTGTGTCCTTAAGAAAATACCATCTTTCTAAGCCACTGGAATTTTTACTTTACTATTTTTAACA
TTAATGGATGTCAGGTCATCAACCTCAAGTCTTTACATATCCATGTATATTCCATATATATTGTTTATATAGGCCCAAGTTTCTCCTTAA
TTGGGATCTATATACTACCAGCACAACATCAAAAACATGTAATTGAATACATCAGAGCTATATATGTAAGGAAATGACTGGTGACCCCAT
TATCATCATTGTTGAATTCATGTTAAGTAGACCCTCTAGGGGACCATAAGGCAATTGAGCACATAACGAAAAATGATGCAATAAGAATGT
ATGCACTCTCTTTGCCAAATGCATGTGCTTTTGTGTAACGTGGATGTAAACAGAATTGCAGTGCTGCCGAAATTCTTGATCTTGGCTAAG
AGAGTATTTTTCCCCTTGTAATTATGACTCTGAGATAAAATTGCCATTTTGAAATTTCCAAAGTAACAACTTTTTTTATTTTATGAATAA
ACTTGGGATTGCAATTTCTCTGATCTGACAATCAATAACTTTAACAAAGATCTAAATAAGTGTTTCAAGGAAAGTTTTCCTAAGCAAATG

>86168_86168_6_SPTLC2-DIAPH3_SPTLC2_chr14_78043109_ENST00000216484_DIAPH3_chr13_60348957_ENST00000400330_length(amino acids)=391AA_BP=252
MAAALQPFPVSGRWVGCGAGLGAAAAAATAYRACLAPGAARKMRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHV
TQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPI
CSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIEGDETGVMDNLLEALQSG
AAFRDRRKRTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVES

--------------------------------------------------------------
>86168_86168_7_SPTLC2-DIAPH3_SPTLC2_chr14_78043110_ENST00000216484_DIAPH3_chr13_60348957_ENST00000267215_length(transcript)=1111nt_BP=825nt
GCGTGGCCTTGGCCGAGACCGGTCCTCTGCGGAGAGGGCCCCGCCCTCTGTGAAGGCCCGCCCGGGAATTGGCGGCGGCGCTGCAGCCAT
TTCCGGTTTCGGGGAGGTGGGTGGGGTGCGGAGCGGGACTTGGAGCAGCCGCCGCCGCTGCCACCGCCTACAGAGCCTGCCTTGCGCCTG
GTGCTGCCAGGAAGATGCGGCCGGAGCCCGGAGGCTGCTGCTGCCGCCGCACGGTGCGGGCGAATGGCTGCGTGGCGAACGGGGAAGTAC
GGAACGGGTACGTGAGGAGCAGCGCTGCAGCCGCAGCCGCAGCCGCCGCCGGCCAGATCCATCATGTTACACAAAATGGAGGACTATATA
AAAGACCGTTTAATGAAGCTTTTGAAGAAACACCAATGCTGGTTGCTGTGCTCACGTATGTGGGGTATGGCGTACTCACCCTCTTTGGAT
ATCTTCGAGATTTCTTGAGGTATTGGAGAATTGAAAAGTGTCACCATGCAACAGAAAGAGAAGAACAAAAGGACTTTGTGTCATTGTATC
AAGATTTTGAAAACTTTTATACAAGGAATCTGTACATGAGGATAAGAGACAACTGGAATCGGCCAATCTGTAGTGTGCCTGGAGCCAGGG
TGGACATCATGGAGAGACAGTCTCATGATTATAACTGGTCCTTCAAGTATACAGGGAATATAATAAAGGGTGTTATAAACATGGGTTCCT
ACAACTATCTTGGATTTGCACGGAATACTGGATCATGTCAAGAAGCAGCCGCCAAAGTCCTTGAGGAGTATGGAGCTGGAGTGTGCAGTA
CTCGGCAGGAAATTGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAA
AAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGGTAATAAAC
CGTATTTATAAATTGCACATTCTTCTTATCTACTTTTATCCTATTGATCTGTGATTTTAGTAGACTGCTGTGAAATTCTCAAGTTCCAAT

>86168_86168_7_SPTLC2-DIAPH3_SPTLC2_chr14_78043110_ENST00000216484_DIAPH3_chr13_60348957_ENST00000267215_length(amino acids)=310AA_BP=252
MAAALQPFPVSGRWVGCGAGLGAAAAAATAYRACLAPGAARKMRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHV
TQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPI
CSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIEGDETGVMDNLLEALQSG

--------------------------------------------------------------
>86168_86168_8_SPTLC2-DIAPH3_SPTLC2_chr14_78043110_ENST00000216484_DIAPH3_chr13_60348957_ENST00000377908_length(transcript)=1244nt_BP=825nt
GCGTGGCCTTGGCCGAGACCGGTCCTCTGCGGAGAGGGCCCCGCCCTCTGTGAAGGCCCGCCCGGGAATTGGCGGCGGCGCTGCAGCCAT
TTCCGGTTTCGGGGAGGTGGGTGGGGTGCGGAGCGGGACTTGGAGCAGCCGCCGCCGCTGCCACCGCCTACAGAGCCTGCCTTGCGCCTG
GTGCTGCCAGGAAGATGCGGCCGGAGCCCGGAGGCTGCTGCTGCCGCCGCACGGTGCGGGCGAATGGCTGCGTGGCGAACGGGGAAGTAC
GGAACGGGTACGTGAGGAGCAGCGCTGCAGCCGCAGCCGCAGCCGCCGCCGGCCAGATCCATCATGTTACACAAAATGGAGGACTATATA
AAAGACCGTTTAATGAAGCTTTTGAAGAAACACCAATGCTGGTTGCTGTGCTCACGTATGTGGGGTATGGCGTACTCACCCTCTTTGGAT
ATCTTCGAGATTTCTTGAGGTATTGGAGAATTGAAAAGTGTCACCATGCAACAGAAAGAGAAGAACAAAAGGACTTTGTGTCATTGTATC
AAGATTTTGAAAACTTTTATACAAGGAATCTGTACATGAGGATAAGAGACAACTGGAATCGGCCAATCTGTAGTGTGCCTGGAGCCAGGG
TGGACATCATGGAGAGACAGTCTCATGATTATAACTGGTCCTTCAAGTATACAGGGAATATAATAAAGGGTGTTATAAACATGGGTTCCT
ACAACTATCTTGGATTTGCACGGAATACTGGATCATGTCAAGAAGCAGCCGCCAAAGTCCTTGAGGAGTATGGAGCTGGAGTGTGCAGTA
CTCGGCAGGAAATTGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAA
AAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGA
AAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATC
TAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAAC

>86168_86168_8_SPTLC2-DIAPH3_SPTLC2_chr14_78043110_ENST00000216484_DIAPH3_chr13_60348957_ENST00000377908_length(amino acids)=392AA_BP=252
MAAALQPFPVSGRWVGCGAGLGAAAAAATAYRACLAPGAARKMRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHV
TQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPI
CSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIEGDETGVMDNLLEALQSG
AAFRDRRKRTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVES

--------------------------------------------------------------
>86168_86168_9_SPTLC2-DIAPH3_SPTLC2_chr14_78043110_ENST00000216484_DIAPH3_chr13_60348957_ENST00000400319_length(transcript)=1244nt_BP=825nt
GCGTGGCCTTGGCCGAGACCGGTCCTCTGCGGAGAGGGCCCCGCCCTCTGTGAAGGCCCGCCCGGGAATTGGCGGCGGCGCTGCAGCCAT
TTCCGGTTTCGGGGAGGTGGGTGGGGTGCGGAGCGGGACTTGGAGCAGCCGCCGCCGCTGCCACCGCCTACAGAGCCTGCCTTGCGCCTG
GTGCTGCCAGGAAGATGCGGCCGGAGCCCGGAGGCTGCTGCTGCCGCCGCACGGTGCGGGCGAATGGCTGCGTGGCGAACGGGGAAGTAC
GGAACGGGTACGTGAGGAGCAGCGCTGCAGCCGCAGCCGCAGCCGCCGCCGGCCAGATCCATCATGTTACACAAAATGGAGGACTATATA
AAAGACCGTTTAATGAAGCTTTTGAAGAAACACCAATGCTGGTTGCTGTGCTCACGTATGTGGGGTATGGCGTACTCACCCTCTTTGGAT
ATCTTCGAGATTTCTTGAGGTATTGGAGAATTGAAAAGTGTCACCATGCAACAGAAAGAGAAGAACAAAAGGACTTTGTGTCATTGTATC
AAGATTTTGAAAACTTTTATACAAGGAATCTGTACATGAGGATAAGAGACAACTGGAATCGGCCAATCTGTAGTGTGCCTGGAGCCAGGG
TGGACATCATGGAGAGACAGTCTCATGATTATAACTGGTCCTTCAAGTATACAGGGAATATAATAAAGGGTGTTATAAACATGGGTTCCT
ACAACTATCTTGGATTTGCACGGAATACTGGATCATGTCAAGAAGCAGCCGCCAAAGTCCTTGAGGAGTATGGAGCTGGAGTGTGCAGTA
CTCGGCAGGAAATTGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAA
AAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGA
AAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATC
TAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAAC

>86168_86168_9_SPTLC2-DIAPH3_SPTLC2_chr14_78043110_ENST00000216484_DIAPH3_chr13_60348957_ENST00000400319_length(amino acids)=392AA_BP=252
MAAALQPFPVSGRWVGCGAGLGAAAAAATAYRACLAPGAARKMRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHV
TQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPI
CSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIEGDETGVMDNLLEALQSG
AAFRDRRKRTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVES

--------------------------------------------------------------
>86168_86168_10_SPTLC2-DIAPH3_SPTLC2_chr14_78043110_ENST00000216484_DIAPH3_chr13_60348957_ENST00000400320_length(transcript)=1244nt_BP=825nt
GCGTGGCCTTGGCCGAGACCGGTCCTCTGCGGAGAGGGCCCCGCCCTCTGTGAAGGCCCGCCCGGGAATTGGCGGCGGCGCTGCAGCCAT
TTCCGGTTTCGGGGAGGTGGGTGGGGTGCGGAGCGGGACTTGGAGCAGCCGCCGCCGCTGCCACCGCCTACAGAGCCTGCCTTGCGCCTG
GTGCTGCCAGGAAGATGCGGCCGGAGCCCGGAGGCTGCTGCTGCCGCCGCACGGTGCGGGCGAATGGCTGCGTGGCGAACGGGGAAGTAC
GGAACGGGTACGTGAGGAGCAGCGCTGCAGCCGCAGCCGCAGCCGCCGCCGGCCAGATCCATCATGTTACACAAAATGGAGGACTATATA
AAAGACCGTTTAATGAAGCTTTTGAAGAAACACCAATGCTGGTTGCTGTGCTCACGTATGTGGGGTATGGCGTACTCACCCTCTTTGGAT
ATCTTCGAGATTTCTTGAGGTATTGGAGAATTGAAAAGTGTCACCATGCAACAGAAAGAGAAGAACAAAAGGACTTTGTGTCATTGTATC
AAGATTTTGAAAACTTTTATACAAGGAATCTGTACATGAGGATAAGAGACAACTGGAATCGGCCAATCTGTAGTGTGCCTGGAGCCAGGG
TGGACATCATGGAGAGACAGTCTCATGATTATAACTGGTCCTTCAAGTATACAGGGAATATAATAAAGGGTGTTATAAACATGGGTTCCT
ACAACTATCTTGGATTTGCACGGAATACTGGATCATGTCAAGAAGCAGCCGCCAAAGTCCTTGAGGAGTATGGAGCTGGAGTGTGCAGTA
CTCGGCAGGAAATTGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAA
AAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGA
AAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATC
TAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAAC

>86168_86168_10_SPTLC2-DIAPH3_SPTLC2_chr14_78043110_ENST00000216484_DIAPH3_chr13_60348957_ENST00000400320_length(amino acids)=392AA_BP=252
MAAALQPFPVSGRWVGCGAGLGAAAAAATAYRACLAPGAARKMRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHV
TQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPI
CSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIEGDETGVMDNLLEALQSG
AAFRDRRKRTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVES

--------------------------------------------------------------
>86168_86168_11_SPTLC2-DIAPH3_SPTLC2_chr14_78043110_ENST00000216484_DIAPH3_chr13_60348957_ENST00000400324_length(transcript)=2245nt_BP=825nt
GCGTGGCCTTGGCCGAGACCGGTCCTCTGCGGAGAGGGCCCCGCCCTCTGTGAAGGCCCGCCCGGGAATTGGCGGCGGCGCTGCAGCCAT
TTCCGGTTTCGGGGAGGTGGGTGGGGTGCGGAGCGGGACTTGGAGCAGCCGCCGCCGCTGCCACCGCCTACAGAGCCTGCCTTGCGCCTG
GTGCTGCCAGGAAGATGCGGCCGGAGCCCGGAGGCTGCTGCTGCCGCCGCACGGTGCGGGCGAATGGCTGCGTGGCGAACGGGGAAGTAC
GGAACGGGTACGTGAGGAGCAGCGCTGCAGCCGCAGCCGCAGCCGCCGCCGGCCAGATCCATCATGTTACACAAAATGGAGGACTATATA
AAAGACCGTTTAATGAAGCTTTTGAAGAAACACCAATGCTGGTTGCTGTGCTCACGTATGTGGGGTATGGCGTACTCACCCTCTTTGGAT
ATCTTCGAGATTTCTTGAGGTATTGGAGAATTGAAAAGTGTCACCATGCAACAGAAAGAGAAGAACAAAAGGACTTTGTGTCATTGTATC
AAGATTTTGAAAACTTTTATACAAGGAATCTGTACATGAGGATAAGAGACAACTGGAATCGGCCAATCTGTAGTGTGCCTGGAGCCAGGG
TGGACATCATGGAGAGACAGTCTCATGATTATAACTGGTCCTTCAAGTATACAGGGAATATAATAAAGGGTGTTATAAACATGGGTTCCT
ACAACTATCTTGGATTTGCACGGAATACTGGATCATGTCAAGAAGCAGCCGCCAAAGTCCTTGAGGAGTATGGAGCTGGAGTGTGCAGTA
CTCGGCAGGAAATTGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAA
AAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGA
AAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATC
TAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAAC
TTCTTGGCTCTTTTTCTAAAAATGAATCAGTTCCCGAAGTTGAAGCCCTGCTGGCAAGATTACGAGCTTTATAAGTTAAACTGGTTTTTA
AAAAAAATGATTAAGCCAAATATAAAGCCATGCTCTAAACTATAACACTTGAAAAAATTGCTTTTATGTAAGTGACTTTATATAGTTTTA
AATTATGATATATATTAGAAAAATAAAGCTAAATATATGATTGCAATGCTTTTTCTATGTACTGGAGGTTTTGGTTTATTCAAGATTGTA
CCGGGCTTTAATCCTTTTTTTTTTTTTTTTGTCTCCTGGTATTCCTCAGTTCTTTATTTGGTGGTTAAATTATACATATTGCTTTAGAGA
GCAGGTAGGTGGCCATGTGTTCAGCAGTGTGTCCTTAAGAAAATACCATCTTTCTAAGCCACTGGAATTTTTACTTTACTATTTTTAACA
TTAATGGATGTCAGGTCATCAACCTCAAGTCTTTACATATCCATGTATATTCCATATATATTGTTTATATAGGCCCAAGTTTCTCCTTAA
TTGGGATCTATATACTACCAGCACAACATCAAAAACATGTAATTGAATACATCAGAGCTATATATGTAAGGAAATGACTGGTGACCCCAT
TATCATCATTGTTGAATTCATGTTAAGTAGACCCTCTAGGGGACCATAAGGCAATTGAGCACATAACGAAAAATGATGCAATAAGAATGT
ATGCACTCTCTTTGCCAAATGCATGTGCTTTTGTGTAACGTGGATGTAAACAGAATTGCAGTGCTGCCGAAATTCTTGATCTTGGCTAAG
AGAGTATTTTTCCCCTTGTAATTATGACTCTGAGATAAAATTGCCATTTTGAAATTTCCAAAGTAACAACTTTTTTTATTTTATGAATAA
ACTTGGGATTGCAATTTCTCTGATCTGACAATCAATAACTTTAACAAAGATCTAAATAAGTGTTTCAAGGAAAGTTTTCCTAAGCAAATG

>86168_86168_11_SPTLC2-DIAPH3_SPTLC2_chr14_78043110_ENST00000216484_DIAPH3_chr13_60348957_ENST00000400324_length(amino acids)=391AA_BP=252
MAAALQPFPVSGRWVGCGAGLGAAAAAATAYRACLAPGAARKMRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHV
TQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPI
CSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIEGDETGVMDNLLEALQSG
AAFRDRRKRTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVES

--------------------------------------------------------------
>86168_86168_12_SPTLC2-DIAPH3_SPTLC2_chr14_78043110_ENST00000216484_DIAPH3_chr13_60348957_ENST00000400330_length(transcript)=2237nt_BP=825nt
GCGTGGCCTTGGCCGAGACCGGTCCTCTGCGGAGAGGGCCCCGCCCTCTGTGAAGGCCCGCCCGGGAATTGGCGGCGGCGCTGCAGCCAT
TTCCGGTTTCGGGGAGGTGGGTGGGGTGCGGAGCGGGACTTGGAGCAGCCGCCGCCGCTGCCACCGCCTACAGAGCCTGCCTTGCGCCTG
GTGCTGCCAGGAAGATGCGGCCGGAGCCCGGAGGCTGCTGCTGCCGCCGCACGGTGCGGGCGAATGGCTGCGTGGCGAACGGGGAAGTAC
GGAACGGGTACGTGAGGAGCAGCGCTGCAGCCGCAGCCGCAGCCGCCGCCGGCCAGATCCATCATGTTACACAAAATGGAGGACTATATA
AAAGACCGTTTAATGAAGCTTTTGAAGAAACACCAATGCTGGTTGCTGTGCTCACGTATGTGGGGTATGGCGTACTCACCCTCTTTGGAT
ATCTTCGAGATTTCTTGAGGTATTGGAGAATTGAAAAGTGTCACCATGCAACAGAAAGAGAAGAACAAAAGGACTTTGTGTCATTGTATC
AAGATTTTGAAAACTTTTATACAAGGAATCTGTACATGAGGATAAGAGACAACTGGAATCGGCCAATCTGTAGTGTGCCTGGAGCCAGGG
TGGACATCATGGAGAGACAGTCTCATGATTATAACTGGTCCTTCAAGTATACAGGGAATATAATAAAGGGTGTTATAAACATGGGTTCCT
ACAACTATCTTGGATTTGCACGGAATACTGGATCATGTCAAGAAGCAGCCGCCAAAGTCCTTGAGGAGTATGGAGCTGGAGTGTGCAGTA
CTCGGCAGGAAATTGAGGGTGATGAGACAGGAGTGATGGATAATCTGCTGGAGGCCTTGCAGTCCGGGGCTGCCTTCCGCGACAGAAGAA
AAAGGACACCGATGCCAAAAGATGTTCGGCAGAGTCTCAGTCCAATGTCTCAGAGGCCTGTTCTGAAAGTTTGTAACCATGAAAATCAGA
AAGTGCAGTTGACAGAAGGGTCACGTTCACACTACAATATCAATTGCAACTCAACAAGGACTCCAGTCGCCAAGGAGCTTAATTATAATC
TAGACACTCATACGTCTACTGGGAGGATCAAGGCAGCTGAGAAGAAGGAAGCGTGTAATGTAGAAAGCAACAGAAAAAAGGAAACGGAAC
TTCTTGGCTCTTTTTCTAAAAATGAATCAGTTCCCGAAGTTGAAGCCCTGCTGGCAAGATTACGAGCTTTATAAGTTAAACTGGTTTTTA
AAAAAAATGATTAAGCCAAATATAAAGCCATGCTCTAAACTATAACACTTGAAAAAATTGCTTTTATGTAAGTGACTTTATATAGTTTTA
AATTATGATATATATTAGAAAAATAAAGCTAAATATATGATTGCAATGCTTTTTCTATGTACTGGAGGTTTTGGTTTATTCAAGATTGTA
CCGGGCTTTAATCCTTTTTTTTTTTTTTTTGTCTCCTGGTATTCCTCAGTTCTTTATTTGGTGGTTAAATTATACATATTGCTTTAGAGA
GCAGGTAGGTGGCCATGTGTTCAGCAGTGTGTCCTTAAGAAAATACCATCTTTCTAAGCCACTGGAATTTTTACTTTACTATTTTTAACA
TTAATGGATGTCAGGTCATCAACCTCAAGTCTTTACATATCCATGTATATTCCATATATATTGTTTATATAGGCCCAAGTTTCTCCTTAA
TTGGGATCTATATACTACCAGCACAACATCAAAAACATGTAATTGAATACATCAGAGCTATATATGTAAGGAAATGACTGGTGACCCCAT
TATCATCATTGTTGAATTCATGTTAAGTAGACCCTCTAGGGGACCATAAGGCAATTGAGCACATAACGAAAAATGATGCAATAAGAATGT
ATGCACTCTCTTTGCCAAATGCATGTGCTTTTGTGTAACGTGGATGTAAACAGAATTGCAGTGCTGCCGAAATTCTTGATCTTGGCTAAG
AGAGTATTTTTCCCCTTGTAATTATGACTCTGAGATAAAATTGCCATTTTGAAATTTCCAAAGTAACAACTTTTTTTATTTTATGAATAA
ACTTGGGATTGCAATTTCTCTGATCTGACAATCAATAACTTTAACAAAGATCTAAATAAGTGTTTCAAGGAAAGTTTTCCTAAGCAAATG

>86168_86168_12_SPTLC2-DIAPH3_SPTLC2_chr14_78043110_ENST00000216484_DIAPH3_chr13_60348957_ENST00000400330_length(amino acids)=391AA_BP=252
MAAALQPFPVSGRWVGCGAGLGAAAAAATAYRACLAPGAARKMRPEPGGCCCRRTVRANGCVANGEVRNGYVRSSAAAAAAAAAGQIHHV
TQNGGLYKRPFNEAFEETPMLVAVLTYVGYGVLTLFGYLRDFLRYWRIEKCHHATEREEQKDFVSLYQDFENFYTRNLYMRIRDNWNRPI
CSVPGARVDIMERQSHDYNWSFKYTGNIIKGVINMGSYNYLGFARNTGSCQEAAAKVLEEYGAGVCSTRQEIEGDETGVMDNLLEALQSG
AAFRDRRKRTPMPKDVRQSLSPMSQRPVLKVCNHENQKVQLTEGSRSHYNINCNSTRTPVAKELNYNLDTHTSTGRIKAAEKKEACNVES

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SPTLC2-DIAPH3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SPTLC2-DIAPH3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for SPTLC2-DIAPH3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source