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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SQRDL-NID1 (FusionGDB2 ID:86195)

Fusion Gene Summary for SQRDL-NID1

Fusion gene summary

Fusion gene information	Fusion gene name: SQRDL-NID1
	Fusion gene ID: 86195
		Hgene	Tgene
	Gene symbol	SQRDL	NID1
	Gene ID	58472	4811
	Gene name	sulfide quinone oxidoreductase	nidogen 1
	Synonyms	CGI-44\|PRO1975\|SQR\|SQRDL	NID
	Cytomap	15q21.1	1q42.3
	Type of gene	protein-coding	protein-coding
	Description	sulfide:quinone oxidoreductase, mitochondrialsulfide dehydrogenase likesulfide quinone reductase-like	nidogen-1NID-1enactinentactinepididymis secretory sperm binding protein
	Modification date	20200313	20200313
	UniProtAcc	.	P14543
	Ensembl transtripts involved in fusion gene	ENST00000260324, ENST00000568606,	ENST00000264187, ENST00000366595,
Fusion gene scores	* DoF score	5 X 4 X 5=100	4 X 6 X 4=96
	# samples	5	7
	** MAII score	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/96*10)=-0.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SQRDL [Title/Abstract] AND NID1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	NID1(236143879)-SQRDL(45981354), # samples:1 SQRDL(45981354)-NID1(236143879), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SQRDL	GO:0070221	sulfide oxidation, using sulfide:quinone oxidoreductase	22852582
Hgene	SQRDL	GO:0070813	hydrogen sulfide metabolic process	22852582

Fusion gene breakpoints across SQRDL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NID1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BU075210	SQRDL	chr15	45981354	-	NID1	chr1	236143879	+

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Fusion Gene ORF analysis for SQRDL-NID1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000260324	ENST00000264187	SQRDL	chr15	45981354	-	NID1	chr1	236143879	+
In-frame	ENST00000260324	ENST00000366595	SQRDL	chr15	45981354	-	NID1	chr1	236143879	+
In-frame	ENST00000568606	ENST00000264187	SQRDL	chr15	45981354	-	NID1	chr1	236143879	+
In-frame	ENST00000568606	ENST00000366595	SQRDL	chr15	45981354	-	NID1	chr1	236143879	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000568606	SQRDL	chr15	45981354	-	ENST00000366595	NID1	chr1	236143879	+	3846	1366	183	1322	379
ENST00000568606	SQRDL	chr15	45981354	-	ENST00000264187	NID1	chr1	236143879	+	3846	1366	183	1322	379
ENST00000260324	SQRDL	chr15	45981354	-	ENST00000366595	NID1	chr1	236143879	+	4043	1563	380	1519	379
ENST00000260324	SQRDL	chr15	45981354	-	ENST00000264187	NID1	chr1	236143879	+	4043	1563	380	1519	379

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000568606	ENST00000366595	SQRDL	chr15	45981354	-	NID1	chr1	236143879	+	0.000814067	0.999186
ENST00000568606	ENST00000264187	SQRDL	chr15	45981354	-	NID1	chr1	236143879	+	0.000814067	0.999186
ENST00000260324	ENST00000366595	SQRDL	chr15	45981354	-	NID1	chr1	236143879	+	0.001028329	0.9989717
ENST00000260324	ENST00000264187	SQRDL	chr15	45981354	-	NID1	chr1	236143879	+	0.001028329	0.9989717

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Fusion Genomic Features for SQRDL-NID1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SQRDL-NID1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:236143879/chr1:45981354)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	NID1 P14543
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell-extracellular matrix interactions.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000264187

106_268

1248.0

Domain

NIDO

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000264187

1208_1244

1248.0

Domain

EGF-like 6

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000264187

386_426

1248.0

Domain

EGF-like 1

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000264187

430_667

1248.0

Domain

Nidogen G2 beta-barrel

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000264187

668_709

1248.0

Domain

EGF-like 2

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000264187

710_751

1248.0

Domain

EGF-like 3%3B calcium-binding

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000264187

758_801

1248.0

Domain

EGF-like 4

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000264187

802_840

1248.0

Domain

EGF-like 5%3B calcium-binding

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000264187

846_919

1248.0

Domain

Thyroglobulin type-1

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000366595

106_268

1115.0

Domain

NIDO

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000366595

1208_1244

1115.0

Domain

EGF-like 6

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000366595

386_426

1115.0

Domain

EGF-like 1

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000366595

430_667

1115.0

Domain

Nidogen G2 beta-barrel

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000366595

668_709

1115.0

Domain

EGF-like 2

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000366595

710_751

1115.0

Domain

EGF-like 3%3B calcium-binding

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000366595

758_801

1115.0

Domain

EGF-like 4

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000366595

802_840

1115.0

Domain

EGF-like 5%3B calcium-binding

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000366595

846_919

1115.0

Domain

Thyroglobulin type-1

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000264187

702_704

1248.0

Motif

Note=Cell attachment site

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000366595

702_704

1115.0

Motif

Note=Cell attachment site

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000264187

1033_1075

1248.0

Repeat

Note=LDL-receptor class B 2

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000264187

1076_1120

1248.0

Repeat

Note=LDL-receptor class B 3

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000264187

1121_1162

1248.0

Repeat

Note=LDL-receptor class B 4

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000264187

990_1032

1248.0

Repeat

Note=LDL-receptor class B 1

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000366595

1033_1075

1115.0

Repeat

Note=LDL-receptor class B 2

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000366595

1076_1120

1115.0

Repeat

Note=LDL-receptor class B 3

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000366595

1121_1162

1115.0

Repeat

Note=LDL-receptor class B 4

Tgene

NID1

chr15:45981354

chr1:236143879

ENST00000366595

990_1032

1115.0

Repeat

Note=LDL-receptor class B 1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SQRDL

chr15:45981354

chr1:236143879

ENST00000260324

344_347

451.0

Nucleotide binding

FAD

Hgene

SQRDL

chr15:45981354

chr1:236143879

ENST00000260324

53_54

451.0

Nucleotide binding

FAD

Hgene

SQRDL

chr15:45981354

chr1:236143879

ENST00000568606

344_347

451.0

Nucleotide binding

FAD

Hgene

SQRDL

chr15:45981354

chr1:236143879

ENST00000568606

53_54

451.0

Nucleotide binding

FAD

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Fusion Gene Sequence for SQRDL-NID1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>86195_86195_1_SQRDL-NID1_SQRDL_chr15_45981354_ENST00000260324_NID1_chr1_236143879_ENST00000264187_length(transcript)=4043nt_BP=1563nt
AGCGTCAGGTGGCCTCGGTGTCCTCCGCCTGTGCGCCCCAGCCTGCGGGGCCGCCCTTCAGGGCGCGCAAGGGGCGAGTCTGTCCAGCCG
GCAGCACCCCAGGCCGGATGGACGCTTGTTCCTGGTTCTGTGCCCCGTGAGCGCTCAACGCCCTGGTGTGTTCACTGACCATGGTGCCTG
GGCTGCGGCGCCGGGCGGGGCACGGCGGGACTTTTCGGGACCTTTCCTGGGGGGAGCCTCGCTTTCCCCGCCTCCAGCCTCCGCCCGGAT
GGCAGGCGGGCGGGGCCCCAGTCCAGGCCTTGAGACCCAGAAGGGAGCGAAGGTTTTTGCTGCGCCAACGCAGTGACCGAAGGCTCCGCT
CACGCCCGGCCTGATCCTGCCTGAAGATGGTGCCACTGGTGGCTGTGGTATCAGGGCCCCGTGCCCAGCTCTTTGCCTGCCTGCTCAGGC
TGGGCACTCAGCAGGTCGGCCCCCTTCAGCTGCACACCGGGGCCAGCCATGCGGCCAGGAACCATTATGAGGTGCTGGTGCTGGGTGGGG
GCAGTGGCGGAATCACCATGGCTGCCCGCATGAAGAGGAAAGTGGGTGCAGAGAATGTGGCCATTGTTGAGCCCAGTGAGAGACATTTCT
ACCAGCCAATCTGGACACTGGTGGGTGCTGGTGCCAAACAATTGTCCTCATCTGGTCGTCCCACGGCAAGTGTGATTCCATCTGGTGTAG
AATGGATCAAAGCTAGAGTGACTGAGTTGAACCCAGACAAGAACTGCATTCACACAGATGACGACGAGAAGATCTCCTACCGATATCTTA
TTATTGCTCTCGGAATCCAGCTGGACTATGAGAAGATTAAAGGCCTACCTGAAGGTTTCGCTCATCCCAAAATAGGGTCGAATTATTCAG
TTAAGACTGTAGAGAAGACATGGAAAGCTCTGCAGGACTTCAAAGAGGGCAATGCCATCTTCACCTTCCCAAATACTCCAGTGAAGTGTG
CTGGAGCCCCTCAGAAGATCATGTACTTATCAGAAGCCTACTTCAGGAAGACAGGGAAGCGATCCAAGGCCAATATCATTTTCAACACTT
CTCTTGGAGCCATTTTCGGGGTTAAGAAGTATGCAGATGCCCTGCAGGAGATCATCCAGGAGCGGAACCTCACTGTTAACTACAAGAAAA
ACCTCATTGAAGTCCGAGCCGATAAACAAGAGGCTGTATTTGAGAACCTGGACAAACCAGGAGAGACCCAAGTGATTTCATATGAAATGC
TTCATGTCACACCTCCAATGAGCCCACCAGATGTCCTCAAGACCAGTCCTGTGGCTGATGCTGCTGGTTGGGTGGATGTGGATAAAGAAA
CTCTGCAACACAGGAGGTACCCAAATGTGTTTGGGATTGGGGACTGCACCAACCTTCCTACGTCAAAGACCGCTGCTGCAGTAGCTGCCC
AGTCAGGAATACTTGATAGGACAATTTCTGTAATTATGAAGAATCAAACACCAACAAAGAAGTTTCCATGTATCTCATGAAAGCTGACCT
GATGCCTTTCCTGTATTGGAATATGATGCTAAGGCCATAACTACTGCTCAGTGAACAATGGCGGCTGCACCCACCTATGCTTGGCCACCC
CAGGGAGCAGGACCTGCCGTTGCCCTGACAACACCTTGGGAGTTGACTGTATCGAACAGAAATGAAGACAAGAGTGCCTTATTTCCTTTC
CAAGTATTTCACAGCAACACTCTACTTGAAGCAACTTGGTCCAGATTGAAAAGTGTCCTCTGGCTGAGTGGCCACTAGGCCCAGACCCAG
CCCAGCCTGAGCCCCAACAACTTTTCCCTCACTGTTCCCCAAAACATGCACCCTGGACTTCTCTAATAGAAAAGTCTCCACCCCTACACA
AGGACAGAACCCTCCACCCCTACCCCCAACCCTCAGACAGACTTATACACCCCTGAGTGAGGATTACATGCCCATCCCAGTGTCCTAGGA
CCTTTTCCCAATACTAGCCCCCCAGTGGTGAACAGAACCTCCCAAATTTGAGTTGCACCCTTCCCTGTGGCCTTATGAGCTCAGCCTCGC
TTTGAGGTACCCACCGTCCTGTCAGCTCCTTGACCTATGAGCCGGGGCCTGACTAGGAAAAGTTGGGAGTTAAGGAGGAAATTAGCATTC
CTTAATGTTTTGTTTTGGTGCTCTGAATTTCTTCTTTATTATAGTCCTATAGTTTTACTCCTCAGTTCCTCACCATCATCATCTTGTCTA
AGACCCCCATTATAATATTCATGCGCTGCTTTTTCATCAAAACCTACCCTGTCCTAGAGATCTATGGGCATTTGGTGGATGATAATGAGC
AGCCCCTCCCAGATAGAATGTCAATATTTGAGCAGTAGGATATTGGCATTTGTTAGTTAAAGGCTTAAATCAAAAGAATGTCCAATGGTA
GGAATTTCAAGGTGTAGGTCAGATATTTGAGAATAGGGGATTTTTTTGATGTGCCTTAAATTATACCAAAGATTACTAATTATTCCTCTT
TGCCCAAAATACTTGCATCCAAGGTTCTAGTCTCTGTTGCTGTGCTGGTCTTTAGCCCCACTGCTTGCACTGATGTCCCTCCTTTTCACG
GAGACCTATCTGAGGTACAGGATGGGGCTGGCACCAGATGATGTCCCACCACAGTCCCTCACCTCCGGCCTCCACATGACAGAACCAATT
TACACTCAACCATGACCTCACCCCTCCTTGGTTTCTCCCTCGATCTGTGGCCCTTTTTGGATGTATTCTTATCTAACAACACAATCCGGA
AAGACTGAATTGAATATTTATACTAATGGTTCATATCCTTTATTGCTCAATGATCTAATTAAAGGGATCATTGCCACATTTCATGTTTAT
ATTTCTACAATTTGTTTAGAAAACATCTCCTGACCATATCAGTAGCTCGTGTTATCTTTTTATCAACTGCTTCCCAGAGTCCTAAAACAA
TAGAAATTTTGGATTGAAAAGTTCAGCATAAGGAGTTTGAGTCAGTAAAGGATGGGATAAAGGAGTCGAGATGATTCAATGAAAAGTATC
ACAAAAAAGAGATTGATCAACAAGAGAAATAAAAAAGCCCAAGAGGAAGTGGTAGGGGAAGGAATTTAAGAACAGCAATAAGTAAAACTC
TTAAGTAACTCCAAAAAGAAAATGGTACATTTTGCCAAAGACCACTTATACTTGAGAACATGGAAGAATTTGCCTGATACTCTCTTTGGG
GAAAAGAGTCTCTCCTCTTTTCCTCAAACCCCAGTACACTCAGCCTCTCTGCCCCACCTTCTCCTGACTTTGTCCTCACTTGCTTCTGCA
GTACATTGGAACCTGAATTGAAAGAAAGTCTTCCTTGAATAATTGGAGTTTGTCTTGAGAGGCAAATATAGCCCCAAGAATCACAAGATT
CGAGGACCATGTAGGTCTTTTACGTAGCCCAAATCCATAAATTAGTCTCACTTTTTGTATTTATCGTTTCATATTAAACCCTCTATATCA
AATGTTCATCATGATTTTGTATGATTTTTATAACTATTTTATTCATTTTATTAGATTTATTCTAAAATTTTTTAATGGTAAATTCTTAAA
CTGTGGAAACCACTGAAGGTGCTTATTAACTGTTCTCCCAGATTTGTACAAGTATTGGATGATTCCTTGAGTTTACAGCTGTACAAATAG
TGTGGAAAATAAACTTTTTTTAAAAAAGAAAAGAATTCCGTGGTTGCTCTCGATCTTGCAATTTCCAAGGAGACGGATGCTTTCCAACCC
CACAAGCAGACCCGGCTGTATGGCATCACCACGGCCCTGTCTCAGTGTCCGCAAGGCACCAATCGGGCGGAATGCCTGAACCCCAGTCAG
CCCAGCAGACGCAAGGCTCTCGAAGGGCTCCAGTATCCTTTTGCTGTGACGAGCTACGGGAAGAATCTGTATTTCACAGACTGGAAGATG

>86195_86195_1_SQRDL-NID1_SQRDL_chr15_45981354_ENST00000260324_NID1_chr1_236143879_ENST00000264187_length(amino acids)=379AA_BP=
MKMVPLVAVVSGPRAQLFACLLRLGTQQVGPLQLHTGASHAARNHYEVLVLGGGSGGITMAARMKRKVGAENVAIVEPSERHFYQPIWTL
VGAGAKQLSSSGRPTASVIPSGVEWIKARVTELNPDKNCIHTDDDEKISYRYLIIALGIQLDYEKIKGLPEGFAHPKIGSNYSVKTVEKT
WKALQDFKEGNAIFTFPNTPVKCAGAPQKIMYLSEAYFRKTGKRSKANIIFNTSLGAIFGVKKYADALQEIIQERNLTVNYKKNLIEVRA
DKQEAVFENLDKPGETQVISYEMLHVTPPMSPPDVLKTSPVADAAGWVDVDKETLQHRRYPNVFGIGDCTNLPTSKTAAAVAAQSGILDR

--------------------------------------------------------------
>86195_86195_2_SQRDL-NID1_SQRDL_chr15_45981354_ENST00000260324_NID1_chr1_236143879_ENST00000366595_length(transcript)=4043nt_BP=1563nt
AGCGTCAGGTGGCCTCGGTGTCCTCCGCCTGTGCGCCCCAGCCTGCGGGGCCGCCCTTCAGGGCGCGCAAGGGGCGAGTCTGTCCAGCCG
GCAGCACCCCAGGCCGGATGGACGCTTGTTCCTGGTTCTGTGCCCCGTGAGCGCTCAACGCCCTGGTGTGTTCACTGACCATGGTGCCTG
GGCTGCGGCGCCGGGCGGGGCACGGCGGGACTTTTCGGGACCTTTCCTGGGGGGAGCCTCGCTTTCCCCGCCTCCAGCCTCCGCCCGGAT
GGCAGGCGGGCGGGGCCCCAGTCCAGGCCTTGAGACCCAGAAGGGAGCGAAGGTTTTTGCTGCGCCAACGCAGTGACCGAAGGCTCCGCT
CACGCCCGGCCTGATCCTGCCTGAAGATGGTGCCACTGGTGGCTGTGGTATCAGGGCCCCGTGCCCAGCTCTTTGCCTGCCTGCTCAGGC
TGGGCACTCAGCAGGTCGGCCCCCTTCAGCTGCACACCGGGGCCAGCCATGCGGCCAGGAACCATTATGAGGTGCTGGTGCTGGGTGGGG
GCAGTGGCGGAATCACCATGGCTGCCCGCATGAAGAGGAAAGTGGGTGCAGAGAATGTGGCCATTGTTGAGCCCAGTGAGAGACATTTCT
ACCAGCCAATCTGGACACTGGTGGGTGCTGGTGCCAAACAATTGTCCTCATCTGGTCGTCCCACGGCAAGTGTGATTCCATCTGGTGTAG
AATGGATCAAAGCTAGAGTGACTGAGTTGAACCCAGACAAGAACTGCATTCACACAGATGACGACGAGAAGATCTCCTACCGATATCTTA
TTATTGCTCTCGGAATCCAGCTGGACTATGAGAAGATTAAAGGCCTACCTGAAGGTTTCGCTCATCCCAAAATAGGGTCGAATTATTCAG
TTAAGACTGTAGAGAAGACATGGAAAGCTCTGCAGGACTTCAAAGAGGGCAATGCCATCTTCACCTTCCCAAATACTCCAGTGAAGTGTG
CTGGAGCCCCTCAGAAGATCATGTACTTATCAGAAGCCTACTTCAGGAAGACAGGGAAGCGATCCAAGGCCAATATCATTTTCAACACTT
CTCTTGGAGCCATTTTCGGGGTTAAGAAGTATGCAGATGCCCTGCAGGAGATCATCCAGGAGCGGAACCTCACTGTTAACTACAAGAAAA
ACCTCATTGAAGTCCGAGCCGATAAACAAGAGGCTGTATTTGAGAACCTGGACAAACCAGGAGAGACCCAAGTGATTTCATATGAAATGC
TTCATGTCACACCTCCAATGAGCCCACCAGATGTCCTCAAGACCAGTCCTGTGGCTGATGCTGCTGGTTGGGTGGATGTGGATAAAGAAA
CTCTGCAACACAGGAGGTACCCAAATGTGTTTGGGATTGGGGACTGCACCAACCTTCCTACGTCAAAGACCGCTGCTGCAGTAGCTGCCC
AGTCAGGAATACTTGATAGGACAATTTCTGTAATTATGAAGAATCAAACACCAACAAAGAAGTTTCCATGTATCTCATGAAAGCTGACCT
GATGCCTTTCCTGTATTGGAATATGATGCTAAGGCCATAACTACTGCTCAGTGAACAATGGCGGCTGCACCCACCTATGCTTGGCCACCC
CAGGGAGCAGGACCTGCCGTTGCCCTGACAACACCTTGGGAGTTGACTGTATCGAACAGAAATGAAGACAAGAGTGCCTTATTTCCTTTC
CAAGTATTTCACAGCAACACTCTACTTGAAGCAACTTGGTCCAGATTGAAAAGTGTCCTCTGGCTGAGTGGCCACTAGGCCCAGACCCAG
CCCAGCCTGAGCCCCAACAACTTTTCCCTCACTGTTCCCCAAAACATGCACCCTGGACTTCTCTAATAGAAAAGTCTCCACCCCTACACA
AGGACAGAACCCTCCACCCCTACCCCCAACCCTCAGACAGACTTATACACCCCTGAGTGAGGATTACATGCCCATCCCAGTGTCCTAGGA
CCTTTTCCCAATACTAGCCCCCCAGTGGTGAACAGAACCTCCCAAATTTGAGTTGCACCCTTCCCTGTGGCCTTATGAGCTCAGCCTCGC
TTTGAGGTACCCACCGTCCTGTCAGCTCCTTGACCTATGAGCCGGGGCCTGACTAGGAAAAGTTGGGAGTTAAGGAGGAAATTAGCATTC
CTTAATGTTTTGTTTTGGTGCTCTGAATTTCTTCTTTATTATAGTCCTATAGTTTTACTCCTCAGTTCCTCACCATCATCATCTTGTCTA
AGACCCCCATTATAATATTCATGCGCTGCTTTTTCATCAAAACCTACCCTGTCCTAGAGATCTATGGGCATTTGGTGGATGATAATGAGC
AGCCCCTCCCAGATAGAATGTCAATATTTGAGCAGTAGGATATTGGCATTTGTTAGTTAAAGGCTTAAATCAAAAGAATGTCCAATGGTA
GGAATTTCAAGGTGTAGGTCAGATATTTGAGAATAGGGGATTTTTTTGATGTGCCTTAAATTATACCAAAGATTACTAATTATTCCTCTT
TGCCCAAAATACTTGCATCCAAGGTTCTAGTCTCTGTTGCTGTGCTGGTCTTTAGCCCCACTGCTTGCACTGATGTCCCTCCTTTTCACG
GAGACCTATCTGAGGTACAGGATGGGGCTGGCACCAGATGATGTCCCACCACAGTCCCTCACCTCCGGCCTCCACATGACAGAACCAATT
TACACTCAACCATGACCTCACCCCTCCTTGGTTTCTCCCTCGATCTGTGGCCCTTTTTGGATGTATTCTTATCTAACAACACAATCCGGA
AAGACTGAATTGAATATTTATACTAATGGTTCATATCCTTTATTGCTCAATGATCTAATTAAAGGGATCATTGCCACATTTCATGTTTAT
ATTTCTACAATTTGTTTAGAAAACATCTCCTGACCATATCAGTAGCTCGTGTTATCTTTTTATCAACTGCTTCCCAGAGTCCTAAAACAA
TAGAAATTTTGGATTGAAAAGTTCAGCATAAGGAGTTTGAGTCAGTAAAGGATGGGATAAAGGAGTCGAGATGATTCAATGAAAAGTATC
ACAAAAAAGAGATTGATCAACAAGAGAAATAAAAAAGCCCAAGAGGAAGTGGTAGGGGAAGGAATTTAAGAACAGCAATAAGTAAAACTC
TTAAGTAACTCCAAAAAGAAAATGGTACATTTTGCCAAAGACCACTTATACTTGAGAACATGGAAGAATTTGCCTGATACTCTCTTTGGG
GAAAAGAGTCTCTCCTCTTTTCCTCAAACCCCAGTACACTCAGCCTCTCTGCCCCACCTTCTCCTGACTTTGTCCTCACTTGCTTCTGCA
GTACATTGGAACCTGAATTGAAAGAAAGTCTTCCTTGAATAATTGGAGTTTGTCTTGAGAGGCAAATATAGCCCCAAGAATCACAAGATT
CGAGGACCATGTAGGTCTTTTACGTAGCCCAAATCCATAAATTAGTCTCACTTTTTGTATTTATCGTTTCATATTAAACCCTCTATATCA
AATGTTCATCATGATTTTGTATGATTTTTATAACTATTTTATTCATTTTATTAGATTTATTCTAAAATTTTTTAATGGTAAATTCTTAAA
CTGTGGAAACCACTGAAGGTGCTTATTAACTGTTCTCCCAGATTTGTACAAGTATTGGATGATTCCTTGAGTTTACAGCTGTACAAATAG
TGTGGAAAATAAACTTTTTTTAAAAAAGAAAAGAATTCCGTGGTTGCTCTCGATCTTGCAATTTCCAAGGAGACGGATGCTTTCCAACCC
CACAAGCAGACCCGGCTGTATGGCATCACCACGGCCCTGTCTCAGTGTCCGCAAGGCACCAATCGGGCGGAATGCCTGAACCCCAGTCAG
CCCAGCAGACGCAAGGCTCTCGAAGGGCTCCAGTATCCTTTTGCTGTGACGAGCTACGGGAAGAATCTGTATTTCACAGACTGGAAGATG

>86195_86195_2_SQRDL-NID1_SQRDL_chr15_45981354_ENST00000260324_NID1_chr1_236143879_ENST00000366595_length(amino acids)=379AA_BP=
MKMVPLVAVVSGPRAQLFACLLRLGTQQVGPLQLHTGASHAARNHYEVLVLGGGSGGITMAARMKRKVGAENVAIVEPSERHFYQPIWTL
VGAGAKQLSSSGRPTASVIPSGVEWIKARVTELNPDKNCIHTDDDEKISYRYLIIALGIQLDYEKIKGLPEGFAHPKIGSNYSVKTVEKT
WKALQDFKEGNAIFTFPNTPVKCAGAPQKIMYLSEAYFRKTGKRSKANIIFNTSLGAIFGVKKYADALQEIIQERNLTVNYKKNLIEVRA
DKQEAVFENLDKPGETQVISYEMLHVTPPMSPPDVLKTSPVADAAGWVDVDKETLQHRRYPNVFGIGDCTNLPTSKTAAAVAAQSGILDR

--------------------------------------------------------------
>86195_86195_3_SQRDL-NID1_SQRDL_chr15_45981354_ENST00000568606_NID1_chr1_236143879_ENST00000264187_length(transcript)=3846nt_BP=1366nt
CTCATTTTCTCTTGCCGCCACCATGTAAGAAGCGCCTTTCGCCTCCCTCCATGATTCTGAGGCCTCCCCAGCCACATGGTACTTGTATGC
CTAGACAGCGGGCACAGGGCTTGCTGGACACAGAAGGCAAGGACTCAGAGAATATCCACCAGATGAAAGAATGACTGCATGACCTGATCC
TGCCTGAAGATGGTGCCACTGGTGGCTGTGGTATCAGGGCCCCGTGCCCAGCTCTTTGCCTGCCTGCTCAGGCTGGGCACTCAGCAGGTC
GGCCCCCTTCAGCTGCACACCGGGGCCAGCCATGCGGCCAGGAACCATTATGAGGTGCTGGTGCTGGGTGGGGGCAGTGGCGGAATCACC
ATGGCTGCCCGCATGAAGAGGAAAGTGGGTGCAGAGAATGTGGCCATTGTTGAGCCCAGTGAGAGACATTTCTACCAGCCAATCTGGACA
CTGGTGGGTGCTGGTGCCAAACAATTGTCCTCATCTGGTCGTCCCACGGCAAGTGTGATTCCATCTGGTGTAGAATGGATCAAAGCTAGA
GTGACTGAGTTGAACCCAGACAAGAACTGCATTCACACAGATGACGACGAGAAGATCTCCTACCGATATCTTATTATTGCTCTCGGAATC
CAGCTGGACTATGAGAAGATTAAAGGCCTACCTGAAGGTTTCGCTCATCCCAAAATAGGGTCGAATTATTCAGTTAAGACTGTAGAGAAG
ACATGGAAAGCTCTGCAGGACTTCAAAGAGGGCAATGCCATCTTCACCTTCCCAAATACTCCAGTGAAGTGTGCTGGAGCCCCTCAGAAG
ATCATGTACTTATCAGAAGCCTACTTCAGGAAGACAGGGAAGCGATCCAAGGCCAATATCATTTTCAACACTTCTCTTGGAGCCATTTTC
GGGGTTAAGAAGTATGCAGATGCCCTGCAGGAGATCATCCAGGAGCGGAACCTCACTGTTAACTACAAGAAAAACCTCATTGAAGTCCGA
GCCGATAAACAAGAGGCTGTATTTGAGAACCTGGACAAACCAGGAGAGACCCAAGTGATTTCATATGAAATGCTTCATGTCACACCTCCA
ATGAGCCCACCAGATGTCCTCAAGACCAGTCCTGTGGCTGATGCTGCTGGTTGGGTGGATGTGGATAAAGAAACTCTGCAACACAGGAGG
TACCCAAATGTGTTTGGGATTGGGGACTGCACCAACCTTCCTACGTCAAAGACCGCTGCTGCAGTAGCTGCCCAGTCAGGAATACTTGAT
AGGACAATTTCTGTAATTATGAAGAATCAAACACCAACAAAGAAGTTTCCATGTATCTCATGAAAGCTGACCTGATGCCTTTCCTGTATT
GGAATATGATGCTAAGGCCATAACTACTGCTCAGTGAACAATGGCGGCTGCACCCACCTATGCTTGGCCACCCCAGGGAGCAGGACCTGC
CGTTGCCCTGACAACACCTTGGGAGTTGACTGTATCGAACAGAAATGAAGACAAGAGTGCCTTATTTCCTTTCCAAGTATTTCACAGCAA
CACTCTACTTGAAGCAACTTGGTCCAGATTGAAAAGTGTCCTCTGGCTGAGTGGCCACTAGGCCCAGACCCAGCCCAGCCTGAGCCCCAA
CAACTTTTCCCTCACTGTTCCCCAAAACATGCACCCTGGACTTCTCTAATAGAAAAGTCTCCACCCCTACACAAGGACAGAACCCTCCAC
CCCTACCCCCAACCCTCAGACAGACTTATACACCCCTGAGTGAGGATTACATGCCCATCCCAGTGTCCTAGGACCTTTTCCCAATACTAG
CCCCCCAGTGGTGAACAGAACCTCCCAAATTTGAGTTGCACCCTTCCCTGTGGCCTTATGAGCTCAGCCTCGCTTTGAGGTACCCACCGT
CCTGTCAGCTCCTTGACCTATGAGCCGGGGCCTGACTAGGAAAAGTTGGGAGTTAAGGAGGAAATTAGCATTCCTTAATGTTTTGTTTTG
GTGCTCTGAATTTCTTCTTTATTATAGTCCTATAGTTTTACTCCTCAGTTCCTCACCATCATCATCTTGTCTAAGACCCCCATTATAATA
TTCATGCGCTGCTTTTTCATCAAAACCTACCCTGTCCTAGAGATCTATGGGCATTTGGTGGATGATAATGAGCAGCCCCTCCCAGATAGA
ATGTCAATATTTGAGCAGTAGGATATTGGCATTTGTTAGTTAAAGGCTTAAATCAAAAGAATGTCCAATGGTAGGAATTTCAAGGTGTAG
GTCAGATATTTGAGAATAGGGGATTTTTTTGATGTGCCTTAAATTATACCAAAGATTACTAATTATTCCTCTTTGCCCAAAATACTTGCA
TCCAAGGTTCTAGTCTCTGTTGCTGTGCTGGTCTTTAGCCCCACTGCTTGCACTGATGTCCCTCCTTTTCACGGAGACCTATCTGAGGTA
CAGGATGGGGCTGGCACCAGATGATGTCCCACCACAGTCCCTCACCTCCGGCCTCCACATGACAGAACCAATTTACACTCAACCATGACC
TCACCCCTCCTTGGTTTCTCCCTCGATCTGTGGCCCTTTTTGGATGTATTCTTATCTAACAACACAATCCGGAAAGACTGAATTGAATAT
TTATACTAATGGTTCATATCCTTTATTGCTCAATGATCTAATTAAAGGGATCATTGCCACATTTCATGTTTATATTTCTACAATTTGTTT
AGAAAACATCTCCTGACCATATCAGTAGCTCGTGTTATCTTTTTATCAACTGCTTCCCAGAGTCCTAAAACAATAGAAATTTTGGATTGA
AAAGTTCAGCATAAGGAGTTTGAGTCAGTAAAGGATGGGATAAAGGAGTCGAGATGATTCAATGAAAAGTATCACAAAAAAGAGATTGAT
CAACAAGAGAAATAAAAAAGCCCAAGAGGAAGTGGTAGGGGAAGGAATTTAAGAACAGCAATAAGTAAAACTCTTAAGTAACTCCAAAAA
GAAAATGGTACATTTTGCCAAAGACCACTTATACTTGAGAACATGGAAGAATTTGCCTGATACTCTCTTTGGGGAAAAGAGTCTCTCCTC
TTTTCCTCAAACCCCAGTACACTCAGCCTCTCTGCCCCACCTTCTCCTGACTTTGTCCTCACTTGCTTCTGCAGTACATTGGAACCTGAA
TTGAAAGAAAGTCTTCCTTGAATAATTGGAGTTTGTCTTGAGAGGCAAATATAGCCCCAAGAATCACAAGATTCGAGGACCATGTAGGTC
TTTTACGTAGCCCAAATCCATAAATTAGTCTCACTTTTTGTATTTATCGTTTCATATTAAACCCTCTATATCAAATGTTCATCATGATTT
TGTATGATTTTTATAACTATTTTATTCATTTTATTAGATTTATTCTAAAATTTTTTAATGGTAAATTCTTAAACTGTGGAAACCACTGAA
GGTGCTTATTAACTGTTCTCCCAGATTTGTACAAGTATTGGATGATTCCTTGAGTTTACAGCTGTACAAATAGTGTGGAAAATAAACTTT
TTTTAAAAAAGAAAAGAATTCCGTGGTTGCTCTCGATCTTGCAATTTCCAAGGAGACGGATGCTTTCCAACCCCACAAGCAGACCCGGCT
GTATGGCATCACCACGGCCCTGTCTCAGTGTCCGCAAGGCACCAATCGGGCGGAATGCCTGAACCCCAGTCAGCCCAGCAGACGCAAGGC
TCTCGAAGGGCTCCAGTATCCTTTTGCTGTGACGAGCTACGGGAAGAATCTGTATTTCACAGACTGGAAGATGGATCCTTGTGCAGGATG

>86195_86195_3_SQRDL-NID1_SQRDL_chr15_45981354_ENST00000568606_NID1_chr1_236143879_ENST00000264187_length(amino acids)=379AA_BP=
MKMVPLVAVVSGPRAQLFACLLRLGTQQVGPLQLHTGASHAARNHYEVLVLGGGSGGITMAARMKRKVGAENVAIVEPSERHFYQPIWTL
VGAGAKQLSSSGRPTASVIPSGVEWIKARVTELNPDKNCIHTDDDEKISYRYLIIALGIQLDYEKIKGLPEGFAHPKIGSNYSVKTVEKT
WKALQDFKEGNAIFTFPNTPVKCAGAPQKIMYLSEAYFRKTGKRSKANIIFNTSLGAIFGVKKYADALQEIIQERNLTVNYKKNLIEVRA
DKQEAVFENLDKPGETQVISYEMLHVTPPMSPPDVLKTSPVADAAGWVDVDKETLQHRRYPNVFGIGDCTNLPTSKTAAAVAAQSGILDR

--------------------------------------------------------------
>86195_86195_4_SQRDL-NID1_SQRDL_chr15_45981354_ENST00000568606_NID1_chr1_236143879_ENST00000366595_length(transcript)=3846nt_BP=1366nt
CTCATTTTCTCTTGCCGCCACCATGTAAGAAGCGCCTTTCGCCTCCCTCCATGATTCTGAGGCCTCCCCAGCCACATGGTACTTGTATGC
CTAGACAGCGGGCACAGGGCTTGCTGGACACAGAAGGCAAGGACTCAGAGAATATCCACCAGATGAAAGAATGACTGCATGACCTGATCC
TGCCTGAAGATGGTGCCACTGGTGGCTGTGGTATCAGGGCCCCGTGCCCAGCTCTTTGCCTGCCTGCTCAGGCTGGGCACTCAGCAGGTC
GGCCCCCTTCAGCTGCACACCGGGGCCAGCCATGCGGCCAGGAACCATTATGAGGTGCTGGTGCTGGGTGGGGGCAGTGGCGGAATCACC
ATGGCTGCCCGCATGAAGAGGAAAGTGGGTGCAGAGAATGTGGCCATTGTTGAGCCCAGTGAGAGACATTTCTACCAGCCAATCTGGACA
CTGGTGGGTGCTGGTGCCAAACAATTGTCCTCATCTGGTCGTCCCACGGCAAGTGTGATTCCATCTGGTGTAGAATGGATCAAAGCTAGA
GTGACTGAGTTGAACCCAGACAAGAACTGCATTCACACAGATGACGACGAGAAGATCTCCTACCGATATCTTATTATTGCTCTCGGAATC
CAGCTGGACTATGAGAAGATTAAAGGCCTACCTGAAGGTTTCGCTCATCCCAAAATAGGGTCGAATTATTCAGTTAAGACTGTAGAGAAG
ACATGGAAAGCTCTGCAGGACTTCAAAGAGGGCAATGCCATCTTCACCTTCCCAAATACTCCAGTGAAGTGTGCTGGAGCCCCTCAGAAG
ATCATGTACTTATCAGAAGCCTACTTCAGGAAGACAGGGAAGCGATCCAAGGCCAATATCATTTTCAACACTTCTCTTGGAGCCATTTTC
GGGGTTAAGAAGTATGCAGATGCCCTGCAGGAGATCATCCAGGAGCGGAACCTCACTGTTAACTACAAGAAAAACCTCATTGAAGTCCGA
GCCGATAAACAAGAGGCTGTATTTGAGAACCTGGACAAACCAGGAGAGACCCAAGTGATTTCATATGAAATGCTTCATGTCACACCTCCA
ATGAGCCCACCAGATGTCCTCAAGACCAGTCCTGTGGCTGATGCTGCTGGTTGGGTGGATGTGGATAAAGAAACTCTGCAACACAGGAGG
TACCCAAATGTGTTTGGGATTGGGGACTGCACCAACCTTCCTACGTCAAAGACCGCTGCTGCAGTAGCTGCCCAGTCAGGAATACTTGAT
AGGACAATTTCTGTAATTATGAAGAATCAAACACCAACAAAGAAGTTTCCATGTATCTCATGAAAGCTGACCTGATGCCTTTCCTGTATT
GGAATATGATGCTAAGGCCATAACTACTGCTCAGTGAACAATGGCGGCTGCACCCACCTATGCTTGGCCACCCCAGGGAGCAGGACCTGC
CGTTGCCCTGACAACACCTTGGGAGTTGACTGTATCGAACAGAAATGAAGACAAGAGTGCCTTATTTCCTTTCCAAGTATTTCACAGCAA
CACTCTACTTGAAGCAACTTGGTCCAGATTGAAAAGTGTCCTCTGGCTGAGTGGCCACTAGGCCCAGACCCAGCCCAGCCTGAGCCCCAA
CAACTTTTCCCTCACTGTTCCCCAAAACATGCACCCTGGACTTCTCTAATAGAAAAGTCTCCACCCCTACACAAGGACAGAACCCTCCAC
CCCTACCCCCAACCCTCAGACAGACTTATACACCCCTGAGTGAGGATTACATGCCCATCCCAGTGTCCTAGGACCTTTTCCCAATACTAG
CCCCCCAGTGGTGAACAGAACCTCCCAAATTTGAGTTGCACCCTTCCCTGTGGCCTTATGAGCTCAGCCTCGCTTTGAGGTACCCACCGT
CCTGTCAGCTCCTTGACCTATGAGCCGGGGCCTGACTAGGAAAAGTTGGGAGTTAAGGAGGAAATTAGCATTCCTTAATGTTTTGTTTTG
GTGCTCTGAATTTCTTCTTTATTATAGTCCTATAGTTTTACTCCTCAGTTCCTCACCATCATCATCTTGTCTAAGACCCCCATTATAATA
TTCATGCGCTGCTTTTTCATCAAAACCTACCCTGTCCTAGAGATCTATGGGCATTTGGTGGATGATAATGAGCAGCCCCTCCCAGATAGA
ATGTCAATATTTGAGCAGTAGGATATTGGCATTTGTTAGTTAAAGGCTTAAATCAAAAGAATGTCCAATGGTAGGAATTTCAAGGTGTAG
GTCAGATATTTGAGAATAGGGGATTTTTTTGATGTGCCTTAAATTATACCAAAGATTACTAATTATTCCTCTTTGCCCAAAATACTTGCA
TCCAAGGTTCTAGTCTCTGTTGCTGTGCTGGTCTTTAGCCCCACTGCTTGCACTGATGTCCCTCCTTTTCACGGAGACCTATCTGAGGTA
CAGGATGGGGCTGGCACCAGATGATGTCCCACCACAGTCCCTCACCTCCGGCCTCCACATGACAGAACCAATTTACACTCAACCATGACC
TCACCCCTCCTTGGTTTCTCCCTCGATCTGTGGCCCTTTTTGGATGTATTCTTATCTAACAACACAATCCGGAAAGACTGAATTGAATAT
TTATACTAATGGTTCATATCCTTTATTGCTCAATGATCTAATTAAAGGGATCATTGCCACATTTCATGTTTATATTTCTACAATTTGTTT
AGAAAACATCTCCTGACCATATCAGTAGCTCGTGTTATCTTTTTATCAACTGCTTCCCAGAGTCCTAAAACAATAGAAATTTTGGATTGA
AAAGTTCAGCATAAGGAGTTTGAGTCAGTAAAGGATGGGATAAAGGAGTCGAGATGATTCAATGAAAAGTATCACAAAAAAGAGATTGAT
CAACAAGAGAAATAAAAAAGCCCAAGAGGAAGTGGTAGGGGAAGGAATTTAAGAACAGCAATAAGTAAAACTCTTAAGTAACTCCAAAAA
GAAAATGGTACATTTTGCCAAAGACCACTTATACTTGAGAACATGGAAGAATTTGCCTGATACTCTCTTTGGGGAAAAGAGTCTCTCCTC
TTTTCCTCAAACCCCAGTACACTCAGCCTCTCTGCCCCACCTTCTCCTGACTTTGTCCTCACTTGCTTCTGCAGTACATTGGAACCTGAA
TTGAAAGAAAGTCTTCCTTGAATAATTGGAGTTTGTCTTGAGAGGCAAATATAGCCCCAAGAATCACAAGATTCGAGGACCATGTAGGTC
TTTTACGTAGCCCAAATCCATAAATTAGTCTCACTTTTTGTATTTATCGTTTCATATTAAACCCTCTATATCAAATGTTCATCATGATTT
TGTATGATTTTTATAACTATTTTATTCATTTTATTAGATTTATTCTAAAATTTTTTAATGGTAAATTCTTAAACTGTGGAAACCACTGAA
GGTGCTTATTAACTGTTCTCCCAGATTTGTACAAGTATTGGATGATTCCTTGAGTTTACAGCTGTACAAATAGTGTGGAAAATAAACTTT
TTTTAAAAAAGAAAAGAATTCCGTGGTTGCTCTCGATCTTGCAATTTCCAAGGAGACGGATGCTTTCCAACCCCACAAGCAGACCCGGCT
GTATGGCATCACCACGGCCCTGTCTCAGTGTCCGCAAGGCACCAATCGGGCGGAATGCCTGAACCCCAGTCAGCCCAGCAGACGCAAGGC
TCTCGAAGGGCTCCAGTATCCTTTTGCTGTGACGAGCTACGGGAAGAATCTGTATTTCACAGACTGGAAGATGGATCCTTGTGCAGGATG

>86195_86195_4_SQRDL-NID1_SQRDL_chr15_45981354_ENST00000568606_NID1_chr1_236143879_ENST00000366595_length(amino acids)=379AA_BP=
MKMVPLVAVVSGPRAQLFACLLRLGTQQVGPLQLHTGASHAARNHYEVLVLGGGSGGITMAARMKRKVGAENVAIVEPSERHFYQPIWTL
VGAGAKQLSSSGRPTASVIPSGVEWIKARVTELNPDKNCIHTDDDEKISYRYLIIALGIQLDYEKIKGLPEGFAHPKIGSNYSVKTVEKT
WKALQDFKEGNAIFTFPNTPVKCAGAPQKIMYLSEAYFRKTGKRSKANIIFNTSLGAIFGVKKYADALQEIIQERNLTVNYKKNLIEVRA
DKQEAVFENLDKPGETQVISYEMLHVTPPMSPPDVLKTSPVADAAGWVDVDKETLQHRRYPNVFGIGDCTNLPTSKTAAAVAAQSGILDR

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SQRDL-NID1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SQRDL-NID1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for SQRDL-NID1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source