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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SQSTM1-NTRK2 (FusionGDB2 ID:86214)

Fusion Gene Summary for SQSTM1-NTRK2

check button Fusion gene summary
Fusion gene informationFusion gene name: SQSTM1-NTRK2
Fusion gene ID: 86214
HgeneTgene
Gene symbol

SQSTM1

NTRK2

Gene ID

8878

4915

Gene namesequestosome 1neurotrophic receptor tyrosine kinase 2
SynonymsA170|DMRV|FTDALS3|NADGP|OSIL|PDB3|ZIP3|p60|p62|p62BEIEE58|GP145-TrkB|OBHD|TRKB|trk-B
Cytomap

5q35.3

9q21.33

Type of geneprotein-codingprotein-coding
Descriptionsequestosome-1EBI3-associated protein of 60 kDaEBI3-associated protein p60EBIAPautophagy receptor p62oxidative stress induced likephosphotyrosine independent ligand for the Lck SH2 domain p62phosphotyrosine-independent ligand for the Lck SH2 domainBDNF/NT-3 growth factors receptorBDNF-tropomyosine receptor kinase Bneurotrophic tyrosine kinase receptor type 2tropomyosin-related kinase Btyrosine kinase receptor B
Modification date2020032720200313
UniProtAcc.

Q16620

Ensembl transtripts involved in fusion geneENST00000360718, ENST00000376929, 
ENST00000389805, ENST00000402874, 
ENST00000510187, ENST00000506690, 
ENST00000277120, ENST00000304053, 
ENST00000323115, ENST00000359847, 
ENST00000376208, ENST00000395866, 
ENST00000395882, ENST00000376213, 
ENST00000376214, 
Fusion gene scores* DoF score29 X 23 X 12=800410 X 9 X 7=630
# samples 3310
** MAII scorelog2(33/8004*10)=-4.60018323765993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/630*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SQSTM1 [Title/Abstract] AND NTRK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSQSTM1(179252226)-NTRK2(87549077), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSQSTM1

GO:0006914

autophagy

20452972

HgeneSQSTM1

GO:0007032

endosome organization

27368102

HgeneSQSTM1

GO:0031397

negative regulation of protein ubiquitination

20452972

HgeneSQSTM1

GO:0061635

regulation of protein complex stability

25127057

HgeneSQSTM1

GO:1905719

protein localization to perinuclear region of cytoplasm

27368102


check buttonFusion gene breakpoints across SQSTM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NTRK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DU-A76L-01ASQSTM1chr5

179252226

-NTRK2chr9

87549077

+
ChimerDB4LGGTCGA-DU-A76L-01ASQSTM1chr5

179252226

+NTRK2chr9

87549077

+
ChimerDB4LGGTCGA-DU-A76LSQSTM1chr5

179252226

+NTRK2chr9

87549077

+


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Fusion Gene ORF analysis for SQSTM1-NTRK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000360718ENST00000277120SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000360718ENST00000304053SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000360718ENST00000323115SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000360718ENST00000359847SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000360718ENST00000376208SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000360718ENST00000395866SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000360718ENST00000395882SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000376929ENST00000277120SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000376929ENST00000304053SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000376929ENST00000323115SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000376929ENST00000359847SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000376929ENST00000376208SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000376929ENST00000395866SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000376929ENST00000395882SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000389805ENST00000277120SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000389805ENST00000304053SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000389805ENST00000323115SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000389805ENST00000359847SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000389805ENST00000376208SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000389805ENST00000395866SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000389805ENST00000395882SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000402874ENST00000277120SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000402874ENST00000304053SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000402874ENST00000323115SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000402874ENST00000359847SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000402874ENST00000376208SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000402874ENST00000395866SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000402874ENST00000395882SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000510187ENST00000277120SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000510187ENST00000304053SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000510187ENST00000323115SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000510187ENST00000359847SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000510187ENST00000376208SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000510187ENST00000395866SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
5CDS-intronENST00000510187ENST00000395882SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
In-frameENST00000360718ENST00000376213SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
In-frameENST00000360718ENST00000376214SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
In-frameENST00000376929ENST00000376213SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
In-frameENST00000376929ENST00000376214SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
In-frameENST00000389805ENST00000376213SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
In-frameENST00000389805ENST00000376214SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
In-frameENST00000402874ENST00000376213SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
In-frameENST00000402874ENST00000376214SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
In-frameENST00000510187ENST00000376213SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
In-frameENST00000510187ENST00000376214SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
intron-3CDSENST00000506690ENST00000376213SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
intron-3CDSENST00000506690ENST00000376214SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
intron-intronENST00000506690ENST00000277120SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
intron-intronENST00000506690ENST00000304053SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
intron-intronENST00000506690ENST00000323115SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
intron-intronENST00000506690ENST00000359847SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
intron-intronENST00000506690ENST00000376208SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
intron-intronENST00000506690ENST00000395866SQSTM1chr5

179252226

+NTRK2chr9

87549077

+
intron-intronENST00000506690ENST00000395882SQSTM1chr5

179252226

+NTRK2chr9

87549077

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000376929SQSTM1chr5179252226+ENST00000376214NTRK2chr987549077+38998623031745480
ENST00000376929SQSTM1chr5179252226+ENST00000376213NTRK2chr987549077+38998623031745480
ENST00000389805SQSTM1chr5179252226+ENST00000376214NTRK2chr987549077+39699321781815545
ENST00000389805SQSTM1chr5179252226+ENST00000376213NTRK2chr987549077+39699321781815545
ENST00000402874SQSTM1chr5179252226+ENST00000376214NTRK2chr987549077+3809772181655545
ENST00000402874SQSTM1chr5179252226+ENST00000376213NTRK2chr987549077+3809772181655545
ENST00000510187SQSTM1chr5179252226+ENST00000376214NTRK2chr987549077+3807770161653545
ENST00000510187SQSTM1chr5179252226+ENST00000376213NTRK2chr987549077+3807770161653545
ENST00000360718SQSTM1chr5179252226+ENST00000376214NTRK2chr987549077+405910223341905523
ENST00000360718SQSTM1chr5179252226+ENST00000376213NTRK2chr987549077+405910223341905523

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000376929ENST00000376214SQSTM1chr5179252226+NTRK2chr987549077+0.0033734660.9966266
ENST00000376929ENST00000376213SQSTM1chr5179252226+NTRK2chr987549077+0.0033734660.9966266
ENST00000389805ENST00000376214SQSTM1chr5179252226+NTRK2chr987549077+0.0019136030.99808645
ENST00000389805ENST00000376213SQSTM1chr5179252226+NTRK2chr987549077+0.0019136030.99808645
ENST00000402874ENST00000376214SQSTM1chr5179252226+NTRK2chr987549077+0.0017680380.99823195
ENST00000402874ENST00000376213SQSTM1chr5179252226+NTRK2chr987549077+0.0017680380.99823195
ENST00000510187ENST00000376214SQSTM1chr5179252226+NTRK2chr987549077+0.0017583430.99824166
ENST00000510187ENST00000376213SQSTM1chr5179252226+NTRK2chr987549077+0.0017583430.99824166
ENST00000360718ENST00000376214SQSTM1chr5179252226+NTRK2chr987549077+0.0031135640.99688643
ENST00000360718ENST00000376213SQSTM1chr5179252226+NTRK2chr987549077+0.0031135640.99688643

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Fusion Genomic Features for SQSTM1-NTRK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SQSTM1chr5179252226+NTRK2chr987549076+0.0002259330.99977404
SQSTM1chr5179252226+NTRK2chr987549076+0.0002259330.99977404
SQSTM1chr5179252226+NTRK2chr987549076+0.0002259330.99977404
SQSTM1chr5179252226+NTRK2chr987549076+0.0002259330.99977404

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SQSTM1-NTRK2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:179252226/chr9:87549077)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NTRK2

Q16620

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:7574684, PubMed:15494731). Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:15494731). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. {ECO:0000250|UniProtKB:P15209, ECO:0000269|PubMed:15494731, ECO:0000269|PubMed:7574684}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000360718+473_102167357.0DomainPB1
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000376929+693_102167357.0DomainPB1
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000389805+583_102251441.0DomainPB1
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000402874+583_102167357.0DomainPB1
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000389805+58228_233251441.0MotifNote=TRAF6-binding
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000389805+58170_220251441.0RegionNote=LIM protein-binding (LB)
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000360718+47122_167167357.0Zinc fingerZZ-type
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000376929+69122_167167357.0Zinc fingerZZ-type
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000389805+58122_167251441.0Zinc fingerZZ-type
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000402874+58122_167167357.0Zinc fingerZZ-type
TgeneNTRK2chr5:179252226chr9:87549077ENST00000304053015148_1960554.0DomainNote=LRRCT
TgeneNTRK2chr5:179252226chr9:87549077ENST00000304053015197_2820554.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr5:179252226chr9:87549077ENST00000304053015295_3650554.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr5:179252226chr9:87549077ENST0000030405301532_610554.0DomainNote=LRRNT
TgeneNTRK2chr5:179252226chr9:87549077ENST00000304053015538_8070554.0DomainProtein kinase
TgeneNTRK2chr5:179252226chr9:87549077ENST000003231151117538_807528823.0DomainProtein kinase
TgeneNTRK2chr5:179252226chr9:87549077ENST00000359847012148_1960478.0DomainNote=LRRCT
TgeneNTRK2chr5:179252226chr9:87549077ENST00000359847012197_2820478.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr5:179252226chr9:87549077ENST00000359847012295_3650478.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr5:179252226chr9:87549077ENST0000035984701232_610478.0DomainNote=LRRNT
TgeneNTRK2chr5:179252226chr9:87549077ENST00000359847012538_8070478.0DomainProtein kinase
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376208014148_1960538.0DomainNote=LRRCT
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376208014197_2820538.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376208014295_3650538.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr5:179252226chr9:87549077ENST0000037620801432_610538.0DomainNote=LRRNT
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376208014538_8070538.0DomainProtein kinase
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762131420538_807528823.0DomainProtein kinase
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395866012148_1960322.0DomainNote=LRRCT
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395866012197_2820322.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395866012295_3650322.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr5:179252226chr9:87549077ENST0000039586601232_610322.0DomainNote=LRRNT
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395866012538_8070322.0DomainProtein kinase
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395882013148_1960478.0DomainNote=LRRCT
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395882013197_2820478.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395882013295_3650478.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr5:179252226chr9:87549077ENST0000039588201332_610478.0DomainNote=LRRNT
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395882013538_8070478.0DomainProtein kinase
TgeneNTRK2chr5:179252226chr9:87549077ENST000002771201319544_552544839.0Nucleotide bindingATP
TgeneNTRK2chr5:179252226chr9:87549077ENST00000304053015544_5520554.0Nucleotide bindingATP
TgeneNTRK2chr5:179252226chr9:87549077ENST000003231151117544_552528823.0Nucleotide bindingATP
TgeneNTRK2chr5:179252226chr9:87549077ENST00000359847012544_5520478.0Nucleotide bindingATP
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376208014544_5520538.0Nucleotide bindingATP
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762131420544_552528823.0Nucleotide bindingATP
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762141521544_552544839.0Nucleotide bindingATP
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395866012544_5520322.0Nucleotide bindingATP
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395882013544_5520478.0Nucleotide bindingATP
TgeneNTRK2chr5:179252226chr9:87549077ENST00000304053015116_1370554.0RepeatNote=LRR 2
TgeneNTRK2chr5:179252226chr9:87549077ENST0000030405301592_1130554.0RepeatNote=LRR 1
TgeneNTRK2chr5:179252226chr9:87549077ENST00000359847012116_1370478.0RepeatNote=LRR 2
TgeneNTRK2chr5:179252226chr9:87549077ENST0000035984701292_1130478.0RepeatNote=LRR 1
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376208014116_1370538.0RepeatNote=LRR 2
TgeneNTRK2chr5:179252226chr9:87549077ENST0000037620801492_1130538.0RepeatNote=LRR 1
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395866012116_1370322.0RepeatNote=LRR 2
TgeneNTRK2chr5:179252226chr9:87549077ENST0000039586601292_1130322.0RepeatNote=LRR 1
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395882013116_1370478.0RepeatNote=LRR 2
TgeneNTRK2chr5:179252226chr9:87549077ENST0000039588201392_1130478.0RepeatNote=LRR 1
TgeneNTRK2chr5:179252226chr9:87549077ENST0000030405301532_4300554.0Topological domainExtracellular
TgeneNTRK2chr5:179252226chr9:87549077ENST00000304053015455_8220554.0Topological domainCytoplasmic
TgeneNTRK2chr5:179252226chr9:87549077ENST0000035984701232_4300478.0Topological domainExtracellular
TgeneNTRK2chr5:179252226chr9:87549077ENST00000359847012455_8220478.0Topological domainCytoplasmic
TgeneNTRK2chr5:179252226chr9:87549077ENST0000037620801432_4300538.0Topological domainExtracellular
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376208014455_8220538.0Topological domainCytoplasmic
TgeneNTRK2chr5:179252226chr9:87549077ENST0000039586601232_4300322.0Topological domainExtracellular
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395866012455_8220322.0Topological domainCytoplasmic
TgeneNTRK2chr5:179252226chr9:87549077ENST0000039588201332_4300478.0Topological domainExtracellular
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395882013455_8220478.0Topological domainCytoplasmic
TgeneNTRK2chr5:179252226chr9:87549077ENST00000304053015431_4540554.0TransmembraneHelical
TgeneNTRK2chr5:179252226chr9:87549077ENST00000359847012431_4540478.0TransmembraneHelical
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376208014431_4540538.0TransmembraneHelical
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395866012431_4540322.0TransmembraneHelical
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395882013431_4540478.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000360718+47272_294167357.0Compositional biasNote=Ser-rich
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000376929+69272_294167357.0Compositional biasNote=Ser-rich
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000389805+58272_294251441.0Compositional biasNote=Ser-rich
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000402874+58272_294167357.0Compositional biasNote=Ser-rich
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000360718+47389_434167357.0DomainUBA
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000376929+69389_434167357.0DomainUBA
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000389805+58389_434251441.0DomainUBA
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000402874+58389_434167357.0DomainUBA
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000360718+47228_233167357.0MotifNote=TRAF6-binding
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000360718+47336_341167357.0MotifNote=LIR
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000376929+69228_233167357.0MotifNote=TRAF6-binding
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000376929+69336_341167357.0MotifNote=LIR
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000389805+58336_341251441.0MotifNote=LIR
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000402874+58228_233167357.0MotifNote=TRAF6-binding
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000402874+58336_341167357.0MotifNote=LIR
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000360718+47170_220167357.0RegionNote=LIM protein-binding (LB)
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000360718+47321_342167357.0RegionMAP1LC3B-binding
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000376929+69170_220167357.0RegionNote=LIM protein-binding (LB)
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000376929+69321_342167357.0RegionMAP1LC3B-binding
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000389805+58321_342251441.0RegionMAP1LC3B-binding
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000402874+58170_220167357.0RegionNote=LIM protein-binding (LB)
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000402874+58321_342167357.0RegionMAP1LC3B-binding
TgeneNTRK2chr5:179252226chr9:87549077ENST000002771201319148_196544839.0DomainNote=LRRCT
TgeneNTRK2chr5:179252226chr9:87549077ENST000002771201319197_282544839.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr5:179252226chr9:87549077ENST000002771201319295_365544839.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr5:179252226chr9:87549077ENST00000277120131932_61544839.0DomainNote=LRRNT
TgeneNTRK2chr5:179252226chr9:87549077ENST000002771201319538_807544839.0DomainProtein kinase
TgeneNTRK2chr5:179252226chr9:87549077ENST000003231151117148_196528823.0DomainNote=LRRCT
TgeneNTRK2chr5:179252226chr9:87549077ENST000003231151117197_282528823.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr5:179252226chr9:87549077ENST000003231151117295_365528823.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr5:179252226chr9:87549077ENST00000323115111732_61528823.0DomainNote=LRRNT
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762131420148_196528823.0DomainNote=LRRCT
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762131420197_282528823.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762131420295_365528823.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376213142032_61528823.0DomainNote=LRRNT
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762141521148_196544839.0DomainNote=LRRCT
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762141521197_282544839.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762141521295_365544839.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376214152132_61544839.0DomainNote=LRRNT
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762141521538_807544839.0DomainProtein kinase
TgeneNTRK2chr5:179252226chr9:87549077ENST000002771201319116_137544839.0RepeatNote=LRR 2
TgeneNTRK2chr5:179252226chr9:87549077ENST00000277120131992_113544839.0RepeatNote=LRR 1
TgeneNTRK2chr5:179252226chr9:87549077ENST000003231151117116_137528823.0RepeatNote=LRR 2
TgeneNTRK2chr5:179252226chr9:87549077ENST00000323115111792_113528823.0RepeatNote=LRR 1
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762131420116_137528823.0RepeatNote=LRR 2
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376213142092_113528823.0RepeatNote=LRR 1
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762141521116_137544839.0RepeatNote=LRR 2
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376214152192_113544839.0RepeatNote=LRR 1
TgeneNTRK2chr5:179252226chr9:87549077ENST00000277120131932_430544839.0Topological domainExtracellular
TgeneNTRK2chr5:179252226chr9:87549077ENST000002771201319455_822544839.0Topological domainCytoplasmic
TgeneNTRK2chr5:179252226chr9:87549077ENST00000323115111732_430528823.0Topological domainExtracellular
TgeneNTRK2chr5:179252226chr9:87549077ENST000003231151117455_822528823.0Topological domainCytoplasmic
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376213142032_430528823.0Topological domainExtracellular
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762131420455_822528823.0Topological domainCytoplasmic
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376214152132_430544839.0Topological domainExtracellular
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762141521455_822544839.0Topological domainCytoplasmic
TgeneNTRK2chr5:179252226chr9:87549077ENST000002771201319431_454544839.0TransmembraneHelical
TgeneNTRK2chr5:179252226chr9:87549077ENST000003231151117431_454528823.0TransmembraneHelical
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762131420431_454528823.0TransmembraneHelical
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762141521431_454544839.0TransmembraneHelical


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Fusion Gene Sequence for SQSTM1-NTRK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>86214_86214_1_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000360718_NTRK2_chr9_87549077_ENST00000376213_length(transcript)=4059nt_BP=1022nt
GTTAGGGAAGGAAGCAGGCAGATGCCCTTGTCTTCTCCTTTACTCCCAAGCCACTAGAAGTCTAAGGCCTTTGTGGGGCTGGGCCCCTCA
GGAGCAGGTCACAGGCAGGGATCTCCCACAGTTGAAGACGGACATGGGCCTGGTCGGATGGGGAATGAGGTGGCACGTTTCTGAAAAGGC
AGCTGGCCCAAGGCTAAATAAGTGCAGCAGCCAAAGCTGCTGCCCCTGTGCACAGGCCCTCCGCCCCCTGCATGTGGCTGTGGTCCAGGG
CCCAGGTCGGAGCACTCACCTTCCAGGAGGTGCCAGAGCAAGGGGGTAGTCTTGCCTCTCACTCCTGCCCTCTGTGGCTCAAGTAGGTGT
GTTTGTTTATAGCCCTGTGAGTGTCCCTTTCATACTTGCCTCAGCCCATTCCAGCAGCTTATGTCCAGCTGAGAACCCCTGGGTGCTCAC
GTGCTGTCTTTTAAACAATCTAGATGAGGACGGGGACTTGGTTGCCTTTTCCAGTGACGAGGAATTGACAATGGCCATGTCCTACGTGAA
GGATGACATCTTCCGAATCTACATTAAAGAGAAAAAAGAGTGCCGGCGGGACCACCGCCCACCGTGTGCTCAGGAGGCGCCCCGCAACAT
GGTGCACCCCAATGTGATCTGCGATGGCTGCAATGGGCCTGTGGTAGGAACCCGCTACAAGTGCAGCGTCTGCCCAGACTACGACTTGTG
TAGCGTCTGCGAGGGAAAGGGCTTGCACCGGGGGCACACCAAGCTCGCATTCCCCAGCCCCTTCGGGCACCTGTCTGAGGGCTTCTCGCA
CAGCCGCTGGCTCCGGAAGGTGAAACACGGACACTTCGGGTGGCCAGGATGGGAAATGGGTCCACCAGGAAACTGGAGCCCACGTCCTCC
TCGTGCAGGGGAGGCCCGCCCTGGCCCCACGGCAGAATCAGCTTCTGGTCCATCGGAGGATCCGAGTGTGAATTTCCTGAAGAACGTTGG
GGAGAGTGTGGCAGCTGCCCTTAGCCCTCTGGTTGTTCAGCACATCAAGCGACATAACATTGTTCTGAAAAGGGAGCTAGGCGAAGGAGC
CTTTGGAAAAGTGTTCCTAGCTGAATGCTATAACCTCTGTCCTGAGCAGGACAAGATCTTGGTGGCAGTGAAGACCCTGAAGGATGCCAG
TGACAATGCACGCAAGGACTTCCACCGTGAGGCCGAGCTCCTGACCAACCTCCAGCATGAGCACATCGTCAAGTTCTATGGCGTCTGCGT
GGAGGGCGACCCCCTCATCATGGTCTTTGAGTACATGAAGCATGGGGACCTCAACAAGTTCCTCAGGGCACACGGCCCTGATGCCGTGCT
GATGGCTGAGGGCAACCCGCCCACGGAACTGACGCAGTCGCAGATGCTGCATATAGCCCAGCAGATCGCCGCGGGCATGGTCTACCTGGC
GTCCCAGCACTTCGTGCACCGCGATTTGGCCACCAGGAACTGCCTGGTCGGGGAGAACTTGCTGGTGAAAATCGGGGACTTTGGGATGTC
CCGGGACGTGTACAGCACTGACTACTACAGGGTCGGTGGCCACACAATGCTGCCCATTCGCTGGATGCCTCCAGAGAGCATCATGTACAG
GAAATTCACGACGGAAAGCGACGTCTGGAGCCTGGGGGTCGTGTTGTGGGAGATTTTCACCTATGGCAAACAGCCCTGGTACCAGCTGTC
AAACAATGAGGTGATAGAGTGTATCACTCAGGGCCGAGTCCTGCAGCGACCCCGCACGTGCCCCCAGGAGGTGTATGAGCTGATGCTGGG
GTGCTGGCAGCGAGAGCCCCACATGAGGAAGAACATCAAGGGCATCCATACCCTCCTTCAGAACTTGGCCAAGGCATCTCCGGTCTACCT
GGACATTCTAGGCTAGGGCCCTTTTCCCCAGACCGATCCTTCCCAACGTACTCCTCAGACGGGCTGAGAGGATGAACATCTTTTAACTGC
CGCTGGAGGCCACCAAGCTGCTCTCCTTCACTCTGACAGTATTAACATCAAAGACTCCGAGAAGCTCTCGAGGGAAGCAGTGTGTACTTC
TTCATCCATAGACACAGTATTGACTTCTTTTTGGCATTATCTCTTTCTCTCTTTCCATCTCCCTTGGTTGTTCCTTTTTCTTTTTTTAAA
TTTTCTTTTTCTTTTTTTTTTCGTCTTCCCTGCTTCACGATTCTTACCCTTTCTTTTGAATCAATCTGGCTTCTGCATTACTATTAACTC
TGCATAGACAAAGGCCTTAACAAACGTAATTTGTTATATCAGCAGACACTCCAGTTTGCCCACCACAACTAACAATGCCTTGTTGTATTC
CTGCCTTTGATGTGGATGAAAAAAAGGGAAAACAAATATTTCACTTAAACTTTGTCACTTCTGCTGTACAGATATCGAGAGTTTCTATGG
ATTCACTTCTATTTATTTATTATTATTACTGTTCTTATTGTTTTTGGATGGCTTAAGCCTGTGTATAAAAAAGAAAACTTGTGTTCAATC
TGTGAAGCCTTTATCTATGGGAGATTAAAACCAGAGAGAAAGAAGATTTATTATGAACCGCAATATGGGAGGAACAAAGACAACCACTGG
GATCAGCTGGTGTCAGTCCCTACTTAGGAAATACTCAGCAACTGTTAGCTGGGAAGAATGTATTCGGCACCTTCCCCTGAGGACCTTTCT
GAGGAGTAAAAAGACTACTGGCCTCTGTGCCATGGATGATTCTTTTCCCATCACCAGAAATGATAGCGTGCAGTAGAGAGCAAAGATGGC
TTCCGTGAGACACAAGATGGCGCATAGTGTGCTCGGACACAGTTTTGTCTTCGTAGGTTGTGATGATAGCACTGGTTTGTTTCTCAAGCG
CTATCCACAGAACCTTTGTCAACTTCAGTTGAAAAGAGGTGGATTCATGTCCAGAGCTCATTTCGGGGTCAGGTGGGAAAGCCAAGAACT
TGGAAAAGATAAGACAAGCTATAAATTCGGAGGCAAGTTTCTTTTACAATGAACTTTTCAGATCTCACTTCCCTCCGACCCCTAACTTCC
ATGCCCACCCGTCCTTTTAACTGTGCAAGCAAAATTGTGCATGGTCTTCGTCGATTAATACCTTGTGTGCAGACACTACTGCTCCAGACG
TCGTTTCCCTGATAGGTAGAGCAGATCCATAAAAAGGTATGACTTATACAATTAGGGGAAGCTAATGGAGTTTATTAGCTGAGTATCAAT
GTCTCTGCGTTGTACGGTGGTGATGGGTTTTAATGAATATGGACCCTGAAGCCTGGAAATCCTCATCCACGTCGAACCCACAGGACTGTG
GGAAGGGCAGAATCAATCCCTAAGGGAAAGGAAACCTCACCCTGAGGGCATCACATGCACTCATGTTCAGTGTACACAGGTCAAGTCCCT
TGCTCTGGGCTCTAGTTGGGAGAGTGGTTTCATTCCAAGTGTACTCCATTGTCAGTATGCTGTTTTTGTTTCCTTCACTCCATTCAAAAA
GTCAAAATACAAAATTTGGCACAGCATGCCAACGGGAGGCTGTGCCCAGACCAAGCACTGGAAGTGTGCTTCTAGGCATAGTCATTGGTT
TTGCAAAAAGAGGGCTCAAATTTAAATAGAAATTTACAGCTATTTGAATGGTCAGATATACCAAGAAAGAAAAATATTTCTGTTCCTCAA
GAAAACTTGCTACCCTCTGTGAGGGGAATTTTGCTAAACTTGACATCTTTATAACATGAGCCAGATTGAAAGGGAGTGATTTTCATTCAT
CTTAGGTCATGTTATTTCATATTTGTTTCTGAAGGTGCGATAGCTCTGTTTTAGGTTTTGCTTGCGCCTGTTAATTACTGGAACACCTTA
TTTTTCATTAAAGGCTTTGAAAGCCAATTCTCAAAAATTCAAAAGTGCAAATTAACAGAACAAAAGGAAATCCAGTAGCAACTGCAGTCA
AGCGAGGGAGTTGACAAGATAAACCTTACGTCCATTCAAGTTATATGCTGGCCTATGAGAGATGAGAGTTGGGTCGTTTGTTCTCTTTGT

>86214_86214_1_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000360718_NTRK2_chr9_87549077_ENST00000376213_length(amino acids)=523AA_BP=229
MPSVAQVGVFVYSPVSVPFILASAHSSSLCPAENPWVLTCCLLNNLDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPP
CAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGP
PGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLVVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILV
AVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQ
IAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTY

--------------------------------------------------------------
>86214_86214_2_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000360718_NTRK2_chr9_87549077_ENST00000376214_length(transcript)=4059nt_BP=1022nt
GTTAGGGAAGGAAGCAGGCAGATGCCCTTGTCTTCTCCTTTACTCCCAAGCCACTAGAAGTCTAAGGCCTTTGTGGGGCTGGGCCCCTCA
GGAGCAGGTCACAGGCAGGGATCTCCCACAGTTGAAGACGGACATGGGCCTGGTCGGATGGGGAATGAGGTGGCACGTTTCTGAAAAGGC
AGCTGGCCCAAGGCTAAATAAGTGCAGCAGCCAAAGCTGCTGCCCCTGTGCACAGGCCCTCCGCCCCCTGCATGTGGCTGTGGTCCAGGG
CCCAGGTCGGAGCACTCACCTTCCAGGAGGTGCCAGAGCAAGGGGGTAGTCTTGCCTCTCACTCCTGCCCTCTGTGGCTCAAGTAGGTGT
GTTTGTTTATAGCCCTGTGAGTGTCCCTTTCATACTTGCCTCAGCCCATTCCAGCAGCTTATGTCCAGCTGAGAACCCCTGGGTGCTCAC
GTGCTGTCTTTTAAACAATCTAGATGAGGACGGGGACTTGGTTGCCTTTTCCAGTGACGAGGAATTGACAATGGCCATGTCCTACGTGAA
GGATGACATCTTCCGAATCTACATTAAAGAGAAAAAAGAGTGCCGGCGGGACCACCGCCCACCGTGTGCTCAGGAGGCGCCCCGCAACAT
GGTGCACCCCAATGTGATCTGCGATGGCTGCAATGGGCCTGTGGTAGGAACCCGCTACAAGTGCAGCGTCTGCCCAGACTACGACTTGTG
TAGCGTCTGCGAGGGAAAGGGCTTGCACCGGGGGCACACCAAGCTCGCATTCCCCAGCCCCTTCGGGCACCTGTCTGAGGGCTTCTCGCA
CAGCCGCTGGCTCCGGAAGGTGAAACACGGACACTTCGGGTGGCCAGGATGGGAAATGGGTCCACCAGGAAACTGGAGCCCACGTCCTCC
TCGTGCAGGGGAGGCCCGCCCTGGCCCCACGGCAGAATCAGCTTCTGGTCCATCGGAGGATCCGAGTGTGAATTTCCTGAAGAACGTTGG
GGAGAGTGTGGCAGCTGCCCTTAGCCCTCTGGTTGTTCAGCACATCAAGCGACATAACATTGTTCTGAAAAGGGAGCTAGGCGAAGGAGC
CTTTGGAAAAGTGTTCCTAGCTGAATGCTATAACCTCTGTCCTGAGCAGGACAAGATCTTGGTGGCAGTGAAGACCCTGAAGGATGCCAG
TGACAATGCACGCAAGGACTTCCACCGTGAGGCCGAGCTCCTGACCAACCTCCAGCATGAGCACATCGTCAAGTTCTATGGCGTCTGCGT
GGAGGGCGACCCCCTCATCATGGTCTTTGAGTACATGAAGCATGGGGACCTCAACAAGTTCCTCAGGGCACACGGCCCTGATGCCGTGCT
GATGGCTGAGGGCAACCCGCCCACGGAACTGACGCAGTCGCAGATGCTGCATATAGCCCAGCAGATCGCCGCGGGCATGGTCTACCTGGC
GTCCCAGCACTTCGTGCACCGCGATTTGGCCACCAGGAACTGCCTGGTCGGGGAGAACTTGCTGGTGAAAATCGGGGACTTTGGGATGTC
CCGGGACGTGTACAGCACTGACTACTACAGGGTCGGTGGCCACACAATGCTGCCCATTCGCTGGATGCCTCCAGAGAGCATCATGTACAG
GAAATTCACGACGGAAAGCGACGTCTGGAGCCTGGGGGTCGTGTTGTGGGAGATTTTCACCTATGGCAAACAGCCCTGGTACCAGCTGTC
AAACAATGAGGTGATAGAGTGTATCACTCAGGGCCGAGTCCTGCAGCGACCCCGCACGTGCCCCCAGGAGGTGTATGAGCTGATGCTGGG
GTGCTGGCAGCGAGAGCCCCACATGAGGAAGAACATCAAGGGCATCCATACCCTCCTTCAGAACTTGGCCAAGGCATCTCCGGTCTACCT
GGACATTCTAGGCTAGGGCCCTTTTCCCCAGACCGATCCTTCCCAACGTACTCCTCAGACGGGCTGAGAGGATGAACATCTTTTAACTGC
CGCTGGAGGCCACCAAGCTGCTCTCCTTCACTCTGACAGTATTAACATCAAAGACTCCGAGAAGCTCTCGAGGGAAGCAGTGTGTACTTC
TTCATCCATAGACACAGTATTGACTTCTTTTTGGCATTATCTCTTTCTCTCTTTCCATCTCCCTTGGTTGTTCCTTTTTCTTTTTTTAAA
TTTTCTTTTTCTTTTTTTTTTCGTCTTCCCTGCTTCACGATTCTTACCCTTTCTTTTGAATCAATCTGGCTTCTGCATTACTATTAACTC
TGCATAGACAAAGGCCTTAACAAACGTAATTTGTTATATCAGCAGACACTCCAGTTTGCCCACCACAACTAACAATGCCTTGTTGTATTC
CTGCCTTTGATGTGGATGAAAAAAAGGGAAAACAAATATTTCACTTAAACTTTGTCACTTCTGCTGTACAGATATCGAGAGTTTCTATGG
ATTCACTTCTATTTATTTATTATTATTACTGTTCTTATTGTTTTTGGATGGCTTAAGCCTGTGTATAAAAAAGAAAACTTGTGTTCAATC
TGTGAAGCCTTTATCTATGGGAGATTAAAACCAGAGAGAAAGAAGATTTATTATGAACCGCAATATGGGAGGAACAAAGACAACCACTGG
GATCAGCTGGTGTCAGTCCCTACTTAGGAAATACTCAGCAACTGTTAGCTGGGAAGAATGTATTCGGCACCTTCCCCTGAGGACCTTTCT
GAGGAGTAAAAAGACTACTGGCCTCTGTGCCATGGATGATTCTTTTCCCATCACCAGAAATGATAGCGTGCAGTAGAGAGCAAAGATGGC
TTCCGTGAGACACAAGATGGCGCATAGTGTGCTCGGACACAGTTTTGTCTTCGTAGGTTGTGATGATAGCACTGGTTTGTTTCTCAAGCG
CTATCCACAGAACCTTTGTCAACTTCAGTTGAAAAGAGGTGGATTCATGTCCAGAGCTCATTTCGGGGTCAGGTGGGAAAGCCAAGAACT
TGGAAAAGATAAGACAAGCTATAAATTCGGAGGCAAGTTTCTTTTACAATGAACTTTTCAGATCTCACTTCCCTCCGACCCCTAACTTCC
ATGCCCACCCGTCCTTTTAACTGTGCAAGCAAAATTGTGCATGGTCTTCGTCGATTAATACCTTGTGTGCAGACACTACTGCTCCAGACG
TCGTTTCCCTGATAGGTAGAGCAGATCCATAAAAAGGTATGACTTATACAATTAGGGGAAGCTAATGGAGTTTATTAGCTGAGTATCAAT
GTCTCTGCGTTGTACGGTGGTGATGGGTTTTAATGAATATGGACCCTGAAGCCTGGAAATCCTCATCCACGTCGAACCCACAGGACTGTG
GGAAGGGCAGAATCAATCCCTAAGGGAAAGGAAACCTCACCCTGAGGGCATCACATGCACTCATGTTCAGTGTACACAGGTCAAGTCCCT
TGCTCTGGGCTCTAGTTGGGAGAGTGGTTTCATTCCAAGTGTACTCCATTGTCAGTATGCTGTTTTTGTTTCCTTCACTCCATTCAAAAA
GTCAAAATACAAAATTTGGCACAGCATGCCAACGGGAGGCTGTGCCCAGACCAAGCACTGGAAGTGTGCTTCTAGGCATAGTCATTGGTT
TTGCAAAAAGAGGGCTCAAATTTAAATAGAAATTTACAGCTATTTGAATGGTCAGATATACCAAGAAAGAAAAATATTTCTGTTCCTCAA
GAAAACTTGCTACCCTCTGTGAGGGGAATTTTGCTAAACTTGACATCTTTATAACATGAGCCAGATTGAAAGGGAGTGATTTTCATTCAT
CTTAGGTCATGTTATTTCATATTTGTTTCTGAAGGTGCGATAGCTCTGTTTTAGGTTTTGCTTGCGCCTGTTAATTACTGGAACACCTTA
TTTTTCATTAAAGGCTTTGAAAGCCAATTCTCAAAAATTCAAAAGTGCAAATTAACAGAACAAAAGGAAATCCAGTAGCAACTGCAGTCA
AGCGAGGGAGTTGACAAGATAAACCTTACGTCCATTCAAGTTATATGCTGGCCTATGAGAGATGAGAGTTGGGTCGTTTGTTCTCTTTGT

>86214_86214_2_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000360718_NTRK2_chr9_87549077_ENST00000376214_length(amino acids)=523AA_BP=229
MPSVAQVGVFVYSPVSVPFILASAHSSSLCPAENPWVLTCCLLNNLDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPP
CAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGP
PGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLVVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILV
AVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQ
IAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTY

--------------------------------------------------------------
>86214_86214_3_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000376929_NTRK2_chr9_87549077_ENST00000376213_length(transcript)=3899nt_BP=862nt
GCGTCGGCTTCCGGCCGCCTTCCGCGGCCACCGCCGGGCCCGCTCCCGCCGCCGACGCCCAGGTGCGCCAGGTGCGGGCCGGGCGGGGGT
CGCGCTCACCTTTCTGGCCGCTGAGTGCCGCGTACCAGGACAGCGAGAGGAAGGCGCACAGGCAGAAGAGCAGCAGCGTCAGGAAGGTGC
CATTGCGGAGCCTCATCTCCTCGGTGTCTGCGAGATTAATCTCTCATGGCCGCTGCACAAGAACCTGGCTTTTAGCTGAACTAAGGAGAA
AGTCCTACAACAGTTTGGCGTGCAACATGGGGCTTGAGAAAGGATGAGGACGGGGACTTGGTTGCCTTTTCCAGTGACGAGGAATTGACA
ATGGCCATGTCCTACGTGAAGGATGACATCTTCCGAATCTACATTAAAGAGAAAAAAGAGTGCCGGCGGGACCACCGCCCACCGTGTGCT
CAGGAGGCGCCCCGCAACATGGTGCACCCCAATGTGATCTGCGATGGCTGCAATGGGCCTGTGGTAGGAACCCGCTACAAGTGCAGCGTC
TGCCCAGACTACGACTTGTGTAGCGTCTGCGAGGGAAAGGGCTTGCACCGGGGGCACACCAAGCTCGCATTCCCCAGCCCCTTCGGGCAC
CTGTCTGAGGGCTTCTCGCACAGCCGCTGGCTCCGGAAGGTGAAACACGGACACTTCGGGTGGCCAGGATGGGAAATGGGTCCACCAGGA
AACTGGAGCCCACGTCCTCCTCGTGCAGGGGAGGCCCGCCCTGGCCCCACGGCAGAATCAGCTTCTGGTCCATCGGAGGATCCGAGTGTG
AATTTCCTGAAGAACGTTGGGGAGAGTGTGGCAGCTGCCCTTAGCCCTCTGGTTGTTCAGCACATCAAGCGACATAACATTGTTCTGAAA
AGGGAGCTAGGCGAAGGAGCCTTTGGAAAAGTGTTCCTAGCTGAATGCTATAACCTCTGTCCTGAGCAGGACAAGATCTTGGTGGCAGTG
AAGACCCTGAAGGATGCCAGTGACAATGCACGCAAGGACTTCCACCGTGAGGCCGAGCTCCTGACCAACCTCCAGCATGAGCACATCGTC
AAGTTCTATGGCGTCTGCGTGGAGGGCGACCCCCTCATCATGGTCTTTGAGTACATGAAGCATGGGGACCTCAACAAGTTCCTCAGGGCA
CACGGCCCTGATGCCGTGCTGATGGCTGAGGGCAACCCGCCCACGGAACTGACGCAGTCGCAGATGCTGCATATAGCCCAGCAGATCGCC
GCGGGCATGGTCTACCTGGCGTCCCAGCACTTCGTGCACCGCGATTTGGCCACCAGGAACTGCCTGGTCGGGGAGAACTTGCTGGTGAAA
ATCGGGGACTTTGGGATGTCCCGGGACGTGTACAGCACTGACTACTACAGGGTCGGTGGCCACACAATGCTGCCCATTCGCTGGATGCCT
CCAGAGAGCATCATGTACAGGAAATTCACGACGGAAAGCGACGTCTGGAGCCTGGGGGTCGTGTTGTGGGAGATTTTCACCTATGGCAAA
CAGCCCTGGTACCAGCTGTCAAACAATGAGGTGATAGAGTGTATCACTCAGGGCCGAGTCCTGCAGCGACCCCGCACGTGCCCCCAGGAG
GTGTATGAGCTGATGCTGGGGTGCTGGCAGCGAGAGCCCCACATGAGGAAGAACATCAAGGGCATCCATACCCTCCTTCAGAACTTGGCC
AAGGCATCTCCGGTCTACCTGGACATTCTAGGCTAGGGCCCTTTTCCCCAGACCGATCCTTCCCAACGTACTCCTCAGACGGGCTGAGAG
GATGAACATCTTTTAACTGCCGCTGGAGGCCACCAAGCTGCTCTCCTTCACTCTGACAGTATTAACATCAAAGACTCCGAGAAGCTCTCG
AGGGAAGCAGTGTGTACTTCTTCATCCATAGACACAGTATTGACTTCTTTTTGGCATTATCTCTTTCTCTCTTTCCATCTCCCTTGGTTG
TTCCTTTTTCTTTTTTTAAATTTTCTTTTTCTTTTTTTTTTCGTCTTCCCTGCTTCACGATTCTTACCCTTTCTTTTGAATCAATCTGGC
TTCTGCATTACTATTAACTCTGCATAGACAAAGGCCTTAACAAACGTAATTTGTTATATCAGCAGACACTCCAGTTTGCCCACCACAACT
AACAATGCCTTGTTGTATTCCTGCCTTTGATGTGGATGAAAAAAAGGGAAAACAAATATTTCACTTAAACTTTGTCACTTCTGCTGTACA
GATATCGAGAGTTTCTATGGATTCACTTCTATTTATTTATTATTATTACTGTTCTTATTGTTTTTGGATGGCTTAAGCCTGTGTATAAAA
AAGAAAACTTGTGTTCAATCTGTGAAGCCTTTATCTATGGGAGATTAAAACCAGAGAGAAAGAAGATTTATTATGAACCGCAATATGGGA
GGAACAAAGACAACCACTGGGATCAGCTGGTGTCAGTCCCTACTTAGGAAATACTCAGCAACTGTTAGCTGGGAAGAATGTATTCGGCAC
CTTCCCCTGAGGACCTTTCTGAGGAGTAAAAAGACTACTGGCCTCTGTGCCATGGATGATTCTTTTCCCATCACCAGAAATGATAGCGTG
CAGTAGAGAGCAAAGATGGCTTCCGTGAGACACAAGATGGCGCATAGTGTGCTCGGACACAGTTTTGTCTTCGTAGGTTGTGATGATAGC
ACTGGTTTGTTTCTCAAGCGCTATCCACAGAACCTTTGTCAACTTCAGTTGAAAAGAGGTGGATTCATGTCCAGAGCTCATTTCGGGGTC
AGGTGGGAAAGCCAAGAACTTGGAAAAGATAAGACAAGCTATAAATTCGGAGGCAAGTTTCTTTTACAATGAACTTTTCAGATCTCACTT
CCCTCCGACCCCTAACTTCCATGCCCACCCGTCCTTTTAACTGTGCAAGCAAAATTGTGCATGGTCTTCGTCGATTAATACCTTGTGTGC
AGACACTACTGCTCCAGACGTCGTTTCCCTGATAGGTAGAGCAGATCCATAAAAAGGTATGACTTATACAATTAGGGGAAGCTAATGGAG
TTTATTAGCTGAGTATCAATGTCTCTGCGTTGTACGGTGGTGATGGGTTTTAATGAATATGGACCCTGAAGCCTGGAAATCCTCATCCAC
GTCGAACCCACAGGACTGTGGGAAGGGCAGAATCAATCCCTAAGGGAAAGGAAACCTCACCCTGAGGGCATCACATGCACTCATGTTCAG
TGTACACAGGTCAAGTCCCTTGCTCTGGGCTCTAGTTGGGAGAGTGGTTTCATTCCAAGTGTACTCCATTGTCAGTATGCTGTTTTTGTT
TCCTTCACTCCATTCAAAAAGTCAAAATACAAAATTTGGCACAGCATGCCAACGGGAGGCTGTGCCCAGACCAAGCACTGGAAGTGTGCT
TCTAGGCATAGTCATTGGTTTTGCAAAAAGAGGGCTCAAATTTAAATAGAAATTTACAGCTATTTGAATGGTCAGATATACCAAGAAAGA
AAAATATTTCTGTTCCTCAAGAAAACTTGCTACCCTCTGTGAGGGGAATTTTGCTAAACTTGACATCTTTATAACATGAGCCAGATTGAA
AGGGAGTGATTTTCATTCATCTTAGGTCATGTTATTTCATATTTGTTTCTGAAGGTGCGATAGCTCTGTTTTAGGTTTTGCTTGCGCCTG
TTAATTACTGGAACACCTTATTTTTCATTAAAGGCTTTGAAAGCCAATTCTCAAAAATTCAAAAGTGCAAATTAACAGAACAAAAGGAAA
TCCAGTAGCAACTGCAGTCAAGCGAGGGAGTTGACAAGATAAACCTTACGTCCATTCAAGTTATATGCTGGCCTATGAGAGATGAGAGTT

>86214_86214_3_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000376929_NTRK2_chr9_87549077_ENST00000376213_length(amino acids)=480AA_BP=186
MRKDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCE
GKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVA
AALSPLVVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDP
LIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVY
STDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQR

--------------------------------------------------------------
>86214_86214_4_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000376929_NTRK2_chr9_87549077_ENST00000376214_length(transcript)=3899nt_BP=862nt
GCGTCGGCTTCCGGCCGCCTTCCGCGGCCACCGCCGGGCCCGCTCCCGCCGCCGACGCCCAGGTGCGCCAGGTGCGGGCCGGGCGGGGGT
CGCGCTCACCTTTCTGGCCGCTGAGTGCCGCGTACCAGGACAGCGAGAGGAAGGCGCACAGGCAGAAGAGCAGCAGCGTCAGGAAGGTGC
CATTGCGGAGCCTCATCTCCTCGGTGTCTGCGAGATTAATCTCTCATGGCCGCTGCACAAGAACCTGGCTTTTAGCTGAACTAAGGAGAA
AGTCCTACAACAGTTTGGCGTGCAACATGGGGCTTGAGAAAGGATGAGGACGGGGACTTGGTTGCCTTTTCCAGTGACGAGGAATTGACA
ATGGCCATGTCCTACGTGAAGGATGACATCTTCCGAATCTACATTAAAGAGAAAAAAGAGTGCCGGCGGGACCACCGCCCACCGTGTGCT
CAGGAGGCGCCCCGCAACATGGTGCACCCCAATGTGATCTGCGATGGCTGCAATGGGCCTGTGGTAGGAACCCGCTACAAGTGCAGCGTC
TGCCCAGACTACGACTTGTGTAGCGTCTGCGAGGGAAAGGGCTTGCACCGGGGGCACACCAAGCTCGCATTCCCCAGCCCCTTCGGGCAC
CTGTCTGAGGGCTTCTCGCACAGCCGCTGGCTCCGGAAGGTGAAACACGGACACTTCGGGTGGCCAGGATGGGAAATGGGTCCACCAGGA
AACTGGAGCCCACGTCCTCCTCGTGCAGGGGAGGCCCGCCCTGGCCCCACGGCAGAATCAGCTTCTGGTCCATCGGAGGATCCGAGTGTG
AATTTCCTGAAGAACGTTGGGGAGAGTGTGGCAGCTGCCCTTAGCCCTCTGGTTGTTCAGCACATCAAGCGACATAACATTGTTCTGAAA
AGGGAGCTAGGCGAAGGAGCCTTTGGAAAAGTGTTCCTAGCTGAATGCTATAACCTCTGTCCTGAGCAGGACAAGATCTTGGTGGCAGTG
AAGACCCTGAAGGATGCCAGTGACAATGCACGCAAGGACTTCCACCGTGAGGCCGAGCTCCTGACCAACCTCCAGCATGAGCACATCGTC
AAGTTCTATGGCGTCTGCGTGGAGGGCGACCCCCTCATCATGGTCTTTGAGTACATGAAGCATGGGGACCTCAACAAGTTCCTCAGGGCA
CACGGCCCTGATGCCGTGCTGATGGCTGAGGGCAACCCGCCCACGGAACTGACGCAGTCGCAGATGCTGCATATAGCCCAGCAGATCGCC
GCGGGCATGGTCTACCTGGCGTCCCAGCACTTCGTGCACCGCGATTTGGCCACCAGGAACTGCCTGGTCGGGGAGAACTTGCTGGTGAAA
ATCGGGGACTTTGGGATGTCCCGGGACGTGTACAGCACTGACTACTACAGGGTCGGTGGCCACACAATGCTGCCCATTCGCTGGATGCCT
CCAGAGAGCATCATGTACAGGAAATTCACGACGGAAAGCGACGTCTGGAGCCTGGGGGTCGTGTTGTGGGAGATTTTCACCTATGGCAAA
CAGCCCTGGTACCAGCTGTCAAACAATGAGGTGATAGAGTGTATCACTCAGGGCCGAGTCCTGCAGCGACCCCGCACGTGCCCCCAGGAG
GTGTATGAGCTGATGCTGGGGTGCTGGCAGCGAGAGCCCCACATGAGGAAGAACATCAAGGGCATCCATACCCTCCTTCAGAACTTGGCC
AAGGCATCTCCGGTCTACCTGGACATTCTAGGCTAGGGCCCTTTTCCCCAGACCGATCCTTCCCAACGTACTCCTCAGACGGGCTGAGAG
GATGAACATCTTTTAACTGCCGCTGGAGGCCACCAAGCTGCTCTCCTTCACTCTGACAGTATTAACATCAAAGACTCCGAGAAGCTCTCG
AGGGAAGCAGTGTGTACTTCTTCATCCATAGACACAGTATTGACTTCTTTTTGGCATTATCTCTTTCTCTCTTTCCATCTCCCTTGGTTG
TTCCTTTTTCTTTTTTTAAATTTTCTTTTTCTTTTTTTTTTCGTCTTCCCTGCTTCACGATTCTTACCCTTTCTTTTGAATCAATCTGGC
TTCTGCATTACTATTAACTCTGCATAGACAAAGGCCTTAACAAACGTAATTTGTTATATCAGCAGACACTCCAGTTTGCCCACCACAACT
AACAATGCCTTGTTGTATTCCTGCCTTTGATGTGGATGAAAAAAAGGGAAAACAAATATTTCACTTAAACTTTGTCACTTCTGCTGTACA
GATATCGAGAGTTTCTATGGATTCACTTCTATTTATTTATTATTATTACTGTTCTTATTGTTTTTGGATGGCTTAAGCCTGTGTATAAAA
AAGAAAACTTGTGTTCAATCTGTGAAGCCTTTATCTATGGGAGATTAAAACCAGAGAGAAAGAAGATTTATTATGAACCGCAATATGGGA
GGAACAAAGACAACCACTGGGATCAGCTGGTGTCAGTCCCTACTTAGGAAATACTCAGCAACTGTTAGCTGGGAAGAATGTATTCGGCAC
CTTCCCCTGAGGACCTTTCTGAGGAGTAAAAAGACTACTGGCCTCTGTGCCATGGATGATTCTTTTCCCATCACCAGAAATGATAGCGTG
CAGTAGAGAGCAAAGATGGCTTCCGTGAGACACAAGATGGCGCATAGTGTGCTCGGACACAGTTTTGTCTTCGTAGGTTGTGATGATAGC
ACTGGTTTGTTTCTCAAGCGCTATCCACAGAACCTTTGTCAACTTCAGTTGAAAAGAGGTGGATTCATGTCCAGAGCTCATTTCGGGGTC
AGGTGGGAAAGCCAAGAACTTGGAAAAGATAAGACAAGCTATAAATTCGGAGGCAAGTTTCTTTTACAATGAACTTTTCAGATCTCACTT
CCCTCCGACCCCTAACTTCCATGCCCACCCGTCCTTTTAACTGTGCAAGCAAAATTGTGCATGGTCTTCGTCGATTAATACCTTGTGTGC
AGACACTACTGCTCCAGACGTCGTTTCCCTGATAGGTAGAGCAGATCCATAAAAAGGTATGACTTATACAATTAGGGGAAGCTAATGGAG
TTTATTAGCTGAGTATCAATGTCTCTGCGTTGTACGGTGGTGATGGGTTTTAATGAATATGGACCCTGAAGCCTGGAAATCCTCATCCAC
GTCGAACCCACAGGACTGTGGGAAGGGCAGAATCAATCCCTAAGGGAAAGGAAACCTCACCCTGAGGGCATCACATGCACTCATGTTCAG
TGTACACAGGTCAAGTCCCTTGCTCTGGGCTCTAGTTGGGAGAGTGGTTTCATTCCAAGTGTACTCCATTGTCAGTATGCTGTTTTTGTT
TCCTTCACTCCATTCAAAAAGTCAAAATACAAAATTTGGCACAGCATGCCAACGGGAGGCTGTGCCCAGACCAAGCACTGGAAGTGTGCT
TCTAGGCATAGTCATTGGTTTTGCAAAAAGAGGGCTCAAATTTAAATAGAAATTTACAGCTATTTGAATGGTCAGATATACCAAGAAAGA
AAAATATTTCTGTTCCTCAAGAAAACTTGCTACCCTCTGTGAGGGGAATTTTGCTAAACTTGACATCTTTATAACATGAGCCAGATTGAA
AGGGAGTGATTTTCATTCATCTTAGGTCATGTTATTTCATATTTGTTTCTGAAGGTGCGATAGCTCTGTTTTAGGTTTTGCTTGCGCCTG
TTAATTACTGGAACACCTTATTTTTCATTAAAGGCTTTGAAAGCCAATTCTCAAAAATTCAAAAGTGCAAATTAACAGAACAAAAGGAAA
TCCAGTAGCAACTGCAGTCAAGCGAGGGAGTTGACAAGATAAACCTTACGTCCATTCAAGTTATATGCTGGCCTATGAGAGATGAGAGTT

>86214_86214_4_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000376929_NTRK2_chr9_87549077_ENST00000376214_length(amino acids)=480AA_BP=186
MRKDEDGDLVAFSSDEELTMAMSYVKDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCE
GKGLHRGHTKLAFPSPFGHLSEGFSHSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVA
AALSPLVVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDP
LIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVY
STDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQR

--------------------------------------------------------------
>86214_86214_5_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000389805_NTRK2_chr9_87549077_ENST00000376213_length(transcript)=3969nt_BP=932nt
AGAGTAGTGAAGGGGCCTCTGCAGGGCGGCTCTCGCGCCGCGACGACGGTGGCGGGGGCGGGGAGGGCGCGAGAGACTCCGCCCCTCTCG
AGGCGGGGCGGGGCCTCCGCGTTCGCTACAAAAGCCGCGCGGCGGCTGCGACCGGGACGGCCCGTTTTCCGCCAGCTCGCCGCTCGCTAT
GGCGTCGCTCACCGTGAAGGCCTACCTTCTGGGCAAGGAGGACGCGGCGCGCGAGATTCGCCGCTTCAGCTTCTGCTGCAGCCCCGAGCC
TGAGGCGGAAGCCGAGGCTGCGGCGGGTCCGGGACCCTGCGAGCGGCTGCTGAGCCGGGTGGCCGCCCTGTTCCCCGCGCTGCGGCCTGG
CGGCTTCCAGGCGCACTACCGCGATGAGGACGGGGACTTGGTTGCCTTTTCCAGTGACGAGGAATTGACAATGGCCATGTCCTACGTGAA
GGATGACATCTTCCGAATCTACATTAAAGAGAAAAAAGAGTGCCGGCGGGACCACCGCCCACCGTGTGCTCAGGAGGCGCCCCGCAACAT
GGTGCACCCCAATGTGATCTGCGATGGCTGCAATGGGCCTGTGGTAGGAACCCGCTACAAGTGCAGCGTCTGCCCAGACTACGACTTGTG
TAGCGTCTGCGAGGGAAAGGGCTTGCACCGGGGGCACACCAAGCTCGCATTCCCCAGCCCCTTCGGGCACCTGTCTGAGGGCTTCTCGCA
CAGCCGCTGGCTCCGGAAGGTGAAACACGGACACTTCGGGTGGCCAGGATGGGAAATGGGTCCACCAGGAAACTGGAGCCCACGTCCTCC
TCGTGCAGGGGAGGCCCGCCCTGGCCCCACGGCAGAATCAGCTTCTGGTCCATCGGAGGATCCGAGTGTGAATTTCCTGAAGAACGTTGG
GGAGAGTGTGGCAGCTGCCCTTAGCCCTCTGGTTGTTCAGCACATCAAGCGACATAACATTGTTCTGAAAAGGGAGCTAGGCGAAGGAGC
CTTTGGAAAAGTGTTCCTAGCTGAATGCTATAACCTCTGTCCTGAGCAGGACAAGATCTTGGTGGCAGTGAAGACCCTGAAGGATGCCAG
TGACAATGCACGCAAGGACTTCCACCGTGAGGCCGAGCTCCTGACCAACCTCCAGCATGAGCACATCGTCAAGTTCTATGGCGTCTGCGT
GGAGGGCGACCCCCTCATCATGGTCTTTGAGTACATGAAGCATGGGGACCTCAACAAGTTCCTCAGGGCACACGGCCCTGATGCCGTGCT
GATGGCTGAGGGCAACCCGCCCACGGAACTGACGCAGTCGCAGATGCTGCATATAGCCCAGCAGATCGCCGCGGGCATGGTCTACCTGGC
GTCCCAGCACTTCGTGCACCGCGATTTGGCCACCAGGAACTGCCTGGTCGGGGAGAACTTGCTGGTGAAAATCGGGGACTTTGGGATGTC
CCGGGACGTGTACAGCACTGACTACTACAGGGTCGGTGGCCACACAATGCTGCCCATTCGCTGGATGCCTCCAGAGAGCATCATGTACAG
GAAATTCACGACGGAAAGCGACGTCTGGAGCCTGGGGGTCGTGTTGTGGGAGATTTTCACCTATGGCAAACAGCCCTGGTACCAGCTGTC
AAACAATGAGGTGATAGAGTGTATCACTCAGGGCCGAGTCCTGCAGCGACCCCGCACGTGCCCCCAGGAGGTGTATGAGCTGATGCTGGG
GTGCTGGCAGCGAGAGCCCCACATGAGGAAGAACATCAAGGGCATCCATACCCTCCTTCAGAACTTGGCCAAGGCATCTCCGGTCTACCT
GGACATTCTAGGCTAGGGCCCTTTTCCCCAGACCGATCCTTCCCAACGTACTCCTCAGACGGGCTGAGAGGATGAACATCTTTTAACTGC
CGCTGGAGGCCACCAAGCTGCTCTCCTTCACTCTGACAGTATTAACATCAAAGACTCCGAGAAGCTCTCGAGGGAAGCAGTGTGTACTTC
TTCATCCATAGACACAGTATTGACTTCTTTTTGGCATTATCTCTTTCTCTCTTTCCATCTCCCTTGGTTGTTCCTTTTTCTTTTTTTAAA
TTTTCTTTTTCTTTTTTTTTTCGTCTTCCCTGCTTCACGATTCTTACCCTTTCTTTTGAATCAATCTGGCTTCTGCATTACTATTAACTC
TGCATAGACAAAGGCCTTAACAAACGTAATTTGTTATATCAGCAGACACTCCAGTTTGCCCACCACAACTAACAATGCCTTGTTGTATTC
CTGCCTTTGATGTGGATGAAAAAAAGGGAAAACAAATATTTCACTTAAACTTTGTCACTTCTGCTGTACAGATATCGAGAGTTTCTATGG
ATTCACTTCTATTTATTTATTATTATTACTGTTCTTATTGTTTTTGGATGGCTTAAGCCTGTGTATAAAAAAGAAAACTTGTGTTCAATC
TGTGAAGCCTTTATCTATGGGAGATTAAAACCAGAGAGAAAGAAGATTTATTATGAACCGCAATATGGGAGGAACAAAGACAACCACTGG
GATCAGCTGGTGTCAGTCCCTACTTAGGAAATACTCAGCAACTGTTAGCTGGGAAGAATGTATTCGGCACCTTCCCCTGAGGACCTTTCT
GAGGAGTAAAAAGACTACTGGCCTCTGTGCCATGGATGATTCTTTTCCCATCACCAGAAATGATAGCGTGCAGTAGAGAGCAAAGATGGC
TTCCGTGAGACACAAGATGGCGCATAGTGTGCTCGGACACAGTTTTGTCTTCGTAGGTTGTGATGATAGCACTGGTTTGTTTCTCAAGCG
CTATCCACAGAACCTTTGTCAACTTCAGTTGAAAAGAGGTGGATTCATGTCCAGAGCTCATTTCGGGGTCAGGTGGGAAAGCCAAGAACT
TGGAAAAGATAAGACAAGCTATAAATTCGGAGGCAAGTTTCTTTTACAATGAACTTTTCAGATCTCACTTCCCTCCGACCCCTAACTTCC
ATGCCCACCCGTCCTTTTAACTGTGCAAGCAAAATTGTGCATGGTCTTCGTCGATTAATACCTTGTGTGCAGACACTACTGCTCCAGACG
TCGTTTCCCTGATAGGTAGAGCAGATCCATAAAAAGGTATGACTTATACAATTAGGGGAAGCTAATGGAGTTTATTAGCTGAGTATCAAT
GTCTCTGCGTTGTACGGTGGTGATGGGTTTTAATGAATATGGACCCTGAAGCCTGGAAATCCTCATCCACGTCGAACCCACAGGACTGTG
GGAAGGGCAGAATCAATCCCTAAGGGAAAGGAAACCTCACCCTGAGGGCATCACATGCACTCATGTTCAGTGTACACAGGTCAAGTCCCT
TGCTCTGGGCTCTAGTTGGGAGAGTGGTTTCATTCCAAGTGTACTCCATTGTCAGTATGCTGTTTTTGTTTCCTTCACTCCATTCAAAAA
GTCAAAATACAAAATTTGGCACAGCATGCCAACGGGAGGCTGTGCCCAGACCAAGCACTGGAAGTGTGCTTCTAGGCATAGTCATTGGTT
TTGCAAAAAGAGGGCTCAAATTTAAATAGAAATTTACAGCTATTTGAATGGTCAGATATACCAAGAAAGAAAAATATTTCTGTTCCTCAA
GAAAACTTGCTACCCTCTGTGAGGGGAATTTTGCTAAACTTGACATCTTTATAACATGAGCCAGATTGAAAGGGAGTGATTTTCATTCAT
CTTAGGTCATGTTATTTCATATTTGTTTCTGAAGGTGCGATAGCTCTGTTTTAGGTTTTGCTTGCGCCTGTTAATTACTGGAACACCTTA
TTTTTCATTAAAGGCTTTGAAAGCCAATTCTCAAAAATTCAAAAGTGCAAATTAACAGAACAAAAGGAAATCCAGTAGCAACTGCAGTCA
AGCGAGGGAGTTGACAAGATAAACCTTACGTCCATTCAAGTTATATGCTGGCCTATGAGAGATGAGAGTTGGGTCGTTTGTTCTCTTTGT

>86214_86214_5_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000389805_NTRK2_chr9_87549077_ENST00000376213_length(amino acids)=545AA_BP=251
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLVVQHIKRHNIVLKRELGEG
AFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAV
LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMY
RKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVY

--------------------------------------------------------------
>86214_86214_6_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000389805_NTRK2_chr9_87549077_ENST00000376214_length(transcript)=3969nt_BP=932nt
AGAGTAGTGAAGGGGCCTCTGCAGGGCGGCTCTCGCGCCGCGACGACGGTGGCGGGGGCGGGGAGGGCGCGAGAGACTCCGCCCCTCTCG
AGGCGGGGCGGGGCCTCCGCGTTCGCTACAAAAGCCGCGCGGCGGCTGCGACCGGGACGGCCCGTTTTCCGCCAGCTCGCCGCTCGCTAT
GGCGTCGCTCACCGTGAAGGCCTACCTTCTGGGCAAGGAGGACGCGGCGCGCGAGATTCGCCGCTTCAGCTTCTGCTGCAGCCCCGAGCC
TGAGGCGGAAGCCGAGGCTGCGGCGGGTCCGGGACCCTGCGAGCGGCTGCTGAGCCGGGTGGCCGCCCTGTTCCCCGCGCTGCGGCCTGG
CGGCTTCCAGGCGCACTACCGCGATGAGGACGGGGACTTGGTTGCCTTTTCCAGTGACGAGGAATTGACAATGGCCATGTCCTACGTGAA
GGATGACATCTTCCGAATCTACATTAAAGAGAAAAAAGAGTGCCGGCGGGACCACCGCCCACCGTGTGCTCAGGAGGCGCCCCGCAACAT
GGTGCACCCCAATGTGATCTGCGATGGCTGCAATGGGCCTGTGGTAGGAACCCGCTACAAGTGCAGCGTCTGCCCAGACTACGACTTGTG
TAGCGTCTGCGAGGGAAAGGGCTTGCACCGGGGGCACACCAAGCTCGCATTCCCCAGCCCCTTCGGGCACCTGTCTGAGGGCTTCTCGCA
CAGCCGCTGGCTCCGGAAGGTGAAACACGGACACTTCGGGTGGCCAGGATGGGAAATGGGTCCACCAGGAAACTGGAGCCCACGTCCTCC
TCGTGCAGGGGAGGCCCGCCCTGGCCCCACGGCAGAATCAGCTTCTGGTCCATCGGAGGATCCGAGTGTGAATTTCCTGAAGAACGTTGG
GGAGAGTGTGGCAGCTGCCCTTAGCCCTCTGGTTGTTCAGCACATCAAGCGACATAACATTGTTCTGAAAAGGGAGCTAGGCGAAGGAGC
CTTTGGAAAAGTGTTCCTAGCTGAATGCTATAACCTCTGTCCTGAGCAGGACAAGATCTTGGTGGCAGTGAAGACCCTGAAGGATGCCAG
TGACAATGCACGCAAGGACTTCCACCGTGAGGCCGAGCTCCTGACCAACCTCCAGCATGAGCACATCGTCAAGTTCTATGGCGTCTGCGT
GGAGGGCGACCCCCTCATCATGGTCTTTGAGTACATGAAGCATGGGGACCTCAACAAGTTCCTCAGGGCACACGGCCCTGATGCCGTGCT
GATGGCTGAGGGCAACCCGCCCACGGAACTGACGCAGTCGCAGATGCTGCATATAGCCCAGCAGATCGCCGCGGGCATGGTCTACCTGGC
GTCCCAGCACTTCGTGCACCGCGATTTGGCCACCAGGAACTGCCTGGTCGGGGAGAACTTGCTGGTGAAAATCGGGGACTTTGGGATGTC
CCGGGACGTGTACAGCACTGACTACTACAGGGTCGGTGGCCACACAATGCTGCCCATTCGCTGGATGCCTCCAGAGAGCATCATGTACAG
GAAATTCACGACGGAAAGCGACGTCTGGAGCCTGGGGGTCGTGTTGTGGGAGATTTTCACCTATGGCAAACAGCCCTGGTACCAGCTGTC
AAACAATGAGGTGATAGAGTGTATCACTCAGGGCCGAGTCCTGCAGCGACCCCGCACGTGCCCCCAGGAGGTGTATGAGCTGATGCTGGG
GTGCTGGCAGCGAGAGCCCCACATGAGGAAGAACATCAAGGGCATCCATACCCTCCTTCAGAACTTGGCCAAGGCATCTCCGGTCTACCT
GGACATTCTAGGCTAGGGCCCTTTTCCCCAGACCGATCCTTCCCAACGTACTCCTCAGACGGGCTGAGAGGATGAACATCTTTTAACTGC
CGCTGGAGGCCACCAAGCTGCTCTCCTTCACTCTGACAGTATTAACATCAAAGACTCCGAGAAGCTCTCGAGGGAAGCAGTGTGTACTTC
TTCATCCATAGACACAGTATTGACTTCTTTTTGGCATTATCTCTTTCTCTCTTTCCATCTCCCTTGGTTGTTCCTTTTTCTTTTTTTAAA
TTTTCTTTTTCTTTTTTTTTTCGTCTTCCCTGCTTCACGATTCTTACCCTTTCTTTTGAATCAATCTGGCTTCTGCATTACTATTAACTC
TGCATAGACAAAGGCCTTAACAAACGTAATTTGTTATATCAGCAGACACTCCAGTTTGCCCACCACAACTAACAATGCCTTGTTGTATTC
CTGCCTTTGATGTGGATGAAAAAAAGGGAAAACAAATATTTCACTTAAACTTTGTCACTTCTGCTGTACAGATATCGAGAGTTTCTATGG
ATTCACTTCTATTTATTTATTATTATTACTGTTCTTATTGTTTTTGGATGGCTTAAGCCTGTGTATAAAAAAGAAAACTTGTGTTCAATC
TGTGAAGCCTTTATCTATGGGAGATTAAAACCAGAGAGAAAGAAGATTTATTATGAACCGCAATATGGGAGGAACAAAGACAACCACTGG
GATCAGCTGGTGTCAGTCCCTACTTAGGAAATACTCAGCAACTGTTAGCTGGGAAGAATGTATTCGGCACCTTCCCCTGAGGACCTTTCT
GAGGAGTAAAAAGACTACTGGCCTCTGTGCCATGGATGATTCTTTTCCCATCACCAGAAATGATAGCGTGCAGTAGAGAGCAAAGATGGC
TTCCGTGAGACACAAGATGGCGCATAGTGTGCTCGGACACAGTTTTGTCTTCGTAGGTTGTGATGATAGCACTGGTTTGTTTCTCAAGCG
CTATCCACAGAACCTTTGTCAACTTCAGTTGAAAAGAGGTGGATTCATGTCCAGAGCTCATTTCGGGGTCAGGTGGGAAAGCCAAGAACT
TGGAAAAGATAAGACAAGCTATAAATTCGGAGGCAAGTTTCTTTTACAATGAACTTTTCAGATCTCACTTCCCTCCGACCCCTAACTTCC
ATGCCCACCCGTCCTTTTAACTGTGCAAGCAAAATTGTGCATGGTCTTCGTCGATTAATACCTTGTGTGCAGACACTACTGCTCCAGACG
TCGTTTCCCTGATAGGTAGAGCAGATCCATAAAAAGGTATGACTTATACAATTAGGGGAAGCTAATGGAGTTTATTAGCTGAGTATCAAT
GTCTCTGCGTTGTACGGTGGTGATGGGTTTTAATGAATATGGACCCTGAAGCCTGGAAATCCTCATCCACGTCGAACCCACAGGACTGTG
GGAAGGGCAGAATCAATCCCTAAGGGAAAGGAAACCTCACCCTGAGGGCATCACATGCACTCATGTTCAGTGTACACAGGTCAAGTCCCT
TGCTCTGGGCTCTAGTTGGGAGAGTGGTTTCATTCCAAGTGTACTCCATTGTCAGTATGCTGTTTTTGTTTCCTTCACTCCATTCAAAAA
GTCAAAATACAAAATTTGGCACAGCATGCCAACGGGAGGCTGTGCCCAGACCAAGCACTGGAAGTGTGCTTCTAGGCATAGTCATTGGTT
TTGCAAAAAGAGGGCTCAAATTTAAATAGAAATTTACAGCTATTTGAATGGTCAGATATACCAAGAAAGAAAAATATTTCTGTTCCTCAA
GAAAACTTGCTACCCTCTGTGAGGGGAATTTTGCTAAACTTGACATCTTTATAACATGAGCCAGATTGAAAGGGAGTGATTTTCATTCAT
CTTAGGTCATGTTATTTCATATTTGTTTCTGAAGGTGCGATAGCTCTGTTTTAGGTTTTGCTTGCGCCTGTTAATTACTGGAACACCTTA
TTTTTCATTAAAGGCTTTGAAAGCCAATTCTCAAAAATTCAAAAGTGCAAATTAACAGAACAAAAGGAAATCCAGTAGCAACTGCAGTCA
AGCGAGGGAGTTGACAAGATAAACCTTACGTCCATTCAAGTTATATGCTGGCCTATGAGAGATGAGAGTTGGGTCGTTTGTTCTCTTTGT

>86214_86214_6_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000389805_NTRK2_chr9_87549077_ENST00000376214_length(amino acids)=545AA_BP=251
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLVVQHIKRHNIVLKRELGEG
AFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAV
LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMY
RKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVY

--------------------------------------------------------------
>86214_86214_7_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000402874_NTRK2_chr9_87549077_ENST00000376213_length(transcript)=3809nt_BP=772nt
GCCAGCTCGCCGCTCGCTATGGCGTCGCTCACCGTGAAGGCCTACCTTCTGGGCAAGGAGGACGCGGCGCGCGAGATTCGCCGCTTCAGC
TTCTGCTGCAGCCCCGAGCCTGAGGCGGAAGCCGAGGCTGCGGCGGGTCCGGGACCCTGCGAGCGGCTGCTGAGCCGGGTGGCCGCCCTG
TTCCCCGCGCTGCGGCCTGGCGGCTTCCAGGCGCACTACCGCGATGAGGACGGGGACTTGGTTGCCTTTTCCAGTGACGAGGAATTGACA
ATGGCCATGTCCTACGTGAAGGATGACATCTTCCGAATCTACATTAAAGAGAAAAAAGAGTGCCGGCGGGACCACCGCCCACCGTGTGCT
CAGGAGGCGCCCCGCAACATGGTGCACCCCAATGTGATCTGCGATGGCTGCAATGGGCCTGTGGTAGGAACCCGCTACAAGTGCAGCGTC
TGCCCAGACTACGACTTGTGTAGCGTCTGCGAGGGAAAGGGCTTGCACCGGGGGCACACCAAGCTCGCATTCCCCAGCCCCTTCGGGCAC
CTGTCTGAGGGCTTCTCGCACAGCCGCTGGCTCCGGAAGGTGAAACACGGACACTTCGGGTGGCCAGGATGGGAAATGGGTCCACCAGGA
AACTGGAGCCCACGTCCTCCTCGTGCAGGGGAGGCCCGCCCTGGCCCCACGGCAGAATCAGCTTCTGGTCCATCGGAGGATCCGAGTGTG
AATTTCCTGAAGAACGTTGGGGAGAGTGTGGCAGCTGCCCTTAGCCCTCTGGTTGTTCAGCACATCAAGCGACATAACATTGTTCTGAAA
AGGGAGCTAGGCGAAGGAGCCTTTGGAAAAGTGTTCCTAGCTGAATGCTATAACCTCTGTCCTGAGCAGGACAAGATCTTGGTGGCAGTG
AAGACCCTGAAGGATGCCAGTGACAATGCACGCAAGGACTTCCACCGTGAGGCCGAGCTCCTGACCAACCTCCAGCATGAGCACATCGTC
AAGTTCTATGGCGTCTGCGTGGAGGGCGACCCCCTCATCATGGTCTTTGAGTACATGAAGCATGGGGACCTCAACAAGTTCCTCAGGGCA
CACGGCCCTGATGCCGTGCTGATGGCTGAGGGCAACCCGCCCACGGAACTGACGCAGTCGCAGATGCTGCATATAGCCCAGCAGATCGCC
GCGGGCATGGTCTACCTGGCGTCCCAGCACTTCGTGCACCGCGATTTGGCCACCAGGAACTGCCTGGTCGGGGAGAACTTGCTGGTGAAA
ATCGGGGACTTTGGGATGTCCCGGGACGTGTACAGCACTGACTACTACAGGGTCGGTGGCCACACAATGCTGCCCATTCGCTGGATGCCT
CCAGAGAGCATCATGTACAGGAAATTCACGACGGAAAGCGACGTCTGGAGCCTGGGGGTCGTGTTGTGGGAGATTTTCACCTATGGCAAA
CAGCCCTGGTACCAGCTGTCAAACAATGAGGTGATAGAGTGTATCACTCAGGGCCGAGTCCTGCAGCGACCCCGCACGTGCCCCCAGGAG
GTGTATGAGCTGATGCTGGGGTGCTGGCAGCGAGAGCCCCACATGAGGAAGAACATCAAGGGCATCCATACCCTCCTTCAGAACTTGGCC
AAGGCATCTCCGGTCTACCTGGACATTCTAGGCTAGGGCCCTTTTCCCCAGACCGATCCTTCCCAACGTACTCCTCAGACGGGCTGAGAG
GATGAACATCTTTTAACTGCCGCTGGAGGCCACCAAGCTGCTCTCCTTCACTCTGACAGTATTAACATCAAAGACTCCGAGAAGCTCTCG
AGGGAAGCAGTGTGTACTTCTTCATCCATAGACACAGTATTGACTTCTTTTTGGCATTATCTCTTTCTCTCTTTCCATCTCCCTTGGTTG
TTCCTTTTTCTTTTTTTAAATTTTCTTTTTCTTTTTTTTTTCGTCTTCCCTGCTTCACGATTCTTACCCTTTCTTTTGAATCAATCTGGC
TTCTGCATTACTATTAACTCTGCATAGACAAAGGCCTTAACAAACGTAATTTGTTATATCAGCAGACACTCCAGTTTGCCCACCACAACT
AACAATGCCTTGTTGTATTCCTGCCTTTGATGTGGATGAAAAAAAGGGAAAACAAATATTTCACTTAAACTTTGTCACTTCTGCTGTACA
GATATCGAGAGTTTCTATGGATTCACTTCTATTTATTTATTATTATTACTGTTCTTATTGTTTTTGGATGGCTTAAGCCTGTGTATAAAA
AAGAAAACTTGTGTTCAATCTGTGAAGCCTTTATCTATGGGAGATTAAAACCAGAGAGAAAGAAGATTTATTATGAACCGCAATATGGGA
GGAACAAAGACAACCACTGGGATCAGCTGGTGTCAGTCCCTACTTAGGAAATACTCAGCAACTGTTAGCTGGGAAGAATGTATTCGGCAC
CTTCCCCTGAGGACCTTTCTGAGGAGTAAAAAGACTACTGGCCTCTGTGCCATGGATGATTCTTTTCCCATCACCAGAAATGATAGCGTG
CAGTAGAGAGCAAAGATGGCTTCCGTGAGACACAAGATGGCGCATAGTGTGCTCGGACACAGTTTTGTCTTCGTAGGTTGTGATGATAGC
ACTGGTTTGTTTCTCAAGCGCTATCCACAGAACCTTTGTCAACTTCAGTTGAAAAGAGGTGGATTCATGTCCAGAGCTCATTTCGGGGTC
AGGTGGGAAAGCCAAGAACTTGGAAAAGATAAGACAAGCTATAAATTCGGAGGCAAGTTTCTTTTACAATGAACTTTTCAGATCTCACTT
CCCTCCGACCCCTAACTTCCATGCCCACCCGTCCTTTTAACTGTGCAAGCAAAATTGTGCATGGTCTTCGTCGATTAATACCTTGTGTGC
AGACACTACTGCTCCAGACGTCGTTTCCCTGATAGGTAGAGCAGATCCATAAAAAGGTATGACTTATACAATTAGGGGAAGCTAATGGAG
TTTATTAGCTGAGTATCAATGTCTCTGCGTTGTACGGTGGTGATGGGTTTTAATGAATATGGACCCTGAAGCCTGGAAATCCTCATCCAC
GTCGAACCCACAGGACTGTGGGAAGGGCAGAATCAATCCCTAAGGGAAAGGAAACCTCACCCTGAGGGCATCACATGCACTCATGTTCAG
TGTACACAGGTCAAGTCCCTTGCTCTGGGCTCTAGTTGGGAGAGTGGTTTCATTCCAAGTGTACTCCATTGTCAGTATGCTGTTTTTGTT
TCCTTCACTCCATTCAAAAAGTCAAAATACAAAATTTGGCACAGCATGCCAACGGGAGGCTGTGCCCAGACCAAGCACTGGAAGTGTGCT
TCTAGGCATAGTCATTGGTTTTGCAAAAAGAGGGCTCAAATTTAAATAGAAATTTACAGCTATTTGAATGGTCAGATATACCAAGAAAGA
AAAATATTTCTGTTCCTCAAGAAAACTTGCTACCCTCTGTGAGGGGAATTTTGCTAAACTTGACATCTTTATAACATGAGCCAGATTGAA
AGGGAGTGATTTTCATTCATCTTAGGTCATGTTATTTCATATTTGTTTCTGAAGGTGCGATAGCTCTGTTTTAGGTTTTGCTTGCGCCTG
TTAATTACTGGAACACCTTATTTTTCATTAAAGGCTTTGAAAGCCAATTCTCAAAAATTCAAAAGTGCAAATTAACAGAACAAAAGGAAA
TCCAGTAGCAACTGCAGTCAAGCGAGGGAGTTGACAAGATAAACCTTACGTCCATTCAAGTTATATGCTGGCCTATGAGAGATGAGAGTT

>86214_86214_7_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000402874_NTRK2_chr9_87549077_ENST00000376213_length(amino acids)=545AA_BP=251
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLVVQHIKRHNIVLKRELGEG
AFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAV
LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMY
RKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVY

--------------------------------------------------------------
>86214_86214_8_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000402874_NTRK2_chr9_87549077_ENST00000376214_length(transcript)=3809nt_BP=772nt
GCCAGCTCGCCGCTCGCTATGGCGTCGCTCACCGTGAAGGCCTACCTTCTGGGCAAGGAGGACGCGGCGCGCGAGATTCGCCGCTTCAGC
TTCTGCTGCAGCCCCGAGCCTGAGGCGGAAGCCGAGGCTGCGGCGGGTCCGGGACCCTGCGAGCGGCTGCTGAGCCGGGTGGCCGCCCTG
TTCCCCGCGCTGCGGCCTGGCGGCTTCCAGGCGCACTACCGCGATGAGGACGGGGACTTGGTTGCCTTTTCCAGTGACGAGGAATTGACA
ATGGCCATGTCCTACGTGAAGGATGACATCTTCCGAATCTACATTAAAGAGAAAAAAGAGTGCCGGCGGGACCACCGCCCACCGTGTGCT
CAGGAGGCGCCCCGCAACATGGTGCACCCCAATGTGATCTGCGATGGCTGCAATGGGCCTGTGGTAGGAACCCGCTACAAGTGCAGCGTC
TGCCCAGACTACGACTTGTGTAGCGTCTGCGAGGGAAAGGGCTTGCACCGGGGGCACACCAAGCTCGCATTCCCCAGCCCCTTCGGGCAC
CTGTCTGAGGGCTTCTCGCACAGCCGCTGGCTCCGGAAGGTGAAACACGGACACTTCGGGTGGCCAGGATGGGAAATGGGTCCACCAGGA
AACTGGAGCCCACGTCCTCCTCGTGCAGGGGAGGCCCGCCCTGGCCCCACGGCAGAATCAGCTTCTGGTCCATCGGAGGATCCGAGTGTG
AATTTCCTGAAGAACGTTGGGGAGAGTGTGGCAGCTGCCCTTAGCCCTCTGGTTGTTCAGCACATCAAGCGACATAACATTGTTCTGAAA
AGGGAGCTAGGCGAAGGAGCCTTTGGAAAAGTGTTCCTAGCTGAATGCTATAACCTCTGTCCTGAGCAGGACAAGATCTTGGTGGCAGTG
AAGACCCTGAAGGATGCCAGTGACAATGCACGCAAGGACTTCCACCGTGAGGCCGAGCTCCTGACCAACCTCCAGCATGAGCACATCGTC
AAGTTCTATGGCGTCTGCGTGGAGGGCGACCCCCTCATCATGGTCTTTGAGTACATGAAGCATGGGGACCTCAACAAGTTCCTCAGGGCA
CACGGCCCTGATGCCGTGCTGATGGCTGAGGGCAACCCGCCCACGGAACTGACGCAGTCGCAGATGCTGCATATAGCCCAGCAGATCGCC
GCGGGCATGGTCTACCTGGCGTCCCAGCACTTCGTGCACCGCGATTTGGCCACCAGGAACTGCCTGGTCGGGGAGAACTTGCTGGTGAAA
ATCGGGGACTTTGGGATGTCCCGGGACGTGTACAGCACTGACTACTACAGGGTCGGTGGCCACACAATGCTGCCCATTCGCTGGATGCCT
CCAGAGAGCATCATGTACAGGAAATTCACGACGGAAAGCGACGTCTGGAGCCTGGGGGTCGTGTTGTGGGAGATTTTCACCTATGGCAAA
CAGCCCTGGTACCAGCTGTCAAACAATGAGGTGATAGAGTGTATCACTCAGGGCCGAGTCCTGCAGCGACCCCGCACGTGCCCCCAGGAG
GTGTATGAGCTGATGCTGGGGTGCTGGCAGCGAGAGCCCCACATGAGGAAGAACATCAAGGGCATCCATACCCTCCTTCAGAACTTGGCC
AAGGCATCTCCGGTCTACCTGGACATTCTAGGCTAGGGCCCTTTTCCCCAGACCGATCCTTCCCAACGTACTCCTCAGACGGGCTGAGAG
GATGAACATCTTTTAACTGCCGCTGGAGGCCACCAAGCTGCTCTCCTTCACTCTGACAGTATTAACATCAAAGACTCCGAGAAGCTCTCG
AGGGAAGCAGTGTGTACTTCTTCATCCATAGACACAGTATTGACTTCTTTTTGGCATTATCTCTTTCTCTCTTTCCATCTCCCTTGGTTG
TTCCTTTTTCTTTTTTTAAATTTTCTTTTTCTTTTTTTTTTCGTCTTCCCTGCTTCACGATTCTTACCCTTTCTTTTGAATCAATCTGGC
TTCTGCATTACTATTAACTCTGCATAGACAAAGGCCTTAACAAACGTAATTTGTTATATCAGCAGACACTCCAGTTTGCCCACCACAACT
AACAATGCCTTGTTGTATTCCTGCCTTTGATGTGGATGAAAAAAAGGGAAAACAAATATTTCACTTAAACTTTGTCACTTCTGCTGTACA
GATATCGAGAGTTTCTATGGATTCACTTCTATTTATTTATTATTATTACTGTTCTTATTGTTTTTGGATGGCTTAAGCCTGTGTATAAAA
AAGAAAACTTGTGTTCAATCTGTGAAGCCTTTATCTATGGGAGATTAAAACCAGAGAGAAAGAAGATTTATTATGAACCGCAATATGGGA
GGAACAAAGACAACCACTGGGATCAGCTGGTGTCAGTCCCTACTTAGGAAATACTCAGCAACTGTTAGCTGGGAAGAATGTATTCGGCAC
CTTCCCCTGAGGACCTTTCTGAGGAGTAAAAAGACTACTGGCCTCTGTGCCATGGATGATTCTTTTCCCATCACCAGAAATGATAGCGTG
CAGTAGAGAGCAAAGATGGCTTCCGTGAGACACAAGATGGCGCATAGTGTGCTCGGACACAGTTTTGTCTTCGTAGGTTGTGATGATAGC
ACTGGTTTGTTTCTCAAGCGCTATCCACAGAACCTTTGTCAACTTCAGTTGAAAAGAGGTGGATTCATGTCCAGAGCTCATTTCGGGGTC
AGGTGGGAAAGCCAAGAACTTGGAAAAGATAAGACAAGCTATAAATTCGGAGGCAAGTTTCTTTTACAATGAACTTTTCAGATCTCACTT
CCCTCCGACCCCTAACTTCCATGCCCACCCGTCCTTTTAACTGTGCAAGCAAAATTGTGCATGGTCTTCGTCGATTAATACCTTGTGTGC
AGACACTACTGCTCCAGACGTCGTTTCCCTGATAGGTAGAGCAGATCCATAAAAAGGTATGACTTATACAATTAGGGGAAGCTAATGGAG
TTTATTAGCTGAGTATCAATGTCTCTGCGTTGTACGGTGGTGATGGGTTTTAATGAATATGGACCCTGAAGCCTGGAAATCCTCATCCAC
GTCGAACCCACAGGACTGTGGGAAGGGCAGAATCAATCCCTAAGGGAAAGGAAACCTCACCCTGAGGGCATCACATGCACTCATGTTCAG
TGTACACAGGTCAAGTCCCTTGCTCTGGGCTCTAGTTGGGAGAGTGGTTTCATTCCAAGTGTACTCCATTGTCAGTATGCTGTTTTTGTT
TCCTTCACTCCATTCAAAAAGTCAAAATACAAAATTTGGCACAGCATGCCAACGGGAGGCTGTGCCCAGACCAAGCACTGGAAGTGTGCT
TCTAGGCATAGTCATTGGTTTTGCAAAAAGAGGGCTCAAATTTAAATAGAAATTTACAGCTATTTGAATGGTCAGATATACCAAGAAAGA
AAAATATTTCTGTTCCTCAAGAAAACTTGCTACCCTCTGTGAGGGGAATTTTGCTAAACTTGACATCTTTATAACATGAGCCAGATTGAA
AGGGAGTGATTTTCATTCATCTTAGGTCATGTTATTTCATATTTGTTTCTGAAGGTGCGATAGCTCTGTTTTAGGTTTTGCTTGCGCCTG
TTAATTACTGGAACACCTTATTTTTCATTAAAGGCTTTGAAAGCCAATTCTCAAAAATTCAAAAGTGCAAATTAACAGAACAAAAGGAAA
TCCAGTAGCAACTGCAGTCAAGCGAGGGAGTTGACAAGATAAACCTTACGTCCATTCAAGTTATATGCTGGCCTATGAGAGATGAGAGTT

>86214_86214_8_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000402874_NTRK2_chr9_87549077_ENST00000376214_length(amino acids)=545AA_BP=251
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLVVQHIKRHNIVLKRELGEG
AFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAV
LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMY
RKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVY

--------------------------------------------------------------
>86214_86214_9_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000510187_NTRK2_chr9_87549077_ENST00000376213_length(transcript)=3807nt_BP=770nt
CAGCTCGCCGCTCGCTATGGCGTCGCTCACCGTGAAGGCCTACCTTCTGGGCAAGGAGGACGCGGCGCGCGAGATTCGCCGCTTCAGCTT
CTGCTGCAGCCCCGAGCCTGAGGCGGAAGCCGAGGCTGCGGCGGGTCCGGGACCCTGCGAGCGGCTGCTGAGCCGGGTGGCCGCCCTGTT
CCCCGCGCTGCGGCCTGGCGGCTTCCAGGCGCACTACCGCGATGAGGACGGGGACTTGGTTGCCTTTTCCAGTGACGAGGAATTGACAAT
GGCCATGTCCTACGTGAAGGATGACATCTTCCGAATCTACATTAAAGAGAAAAAAGAGTGCCGGCGGGACCACCGCCCACCGTGTGCTCA
GGAGGCGCCCCGCAACATGGTGCACCCCAATGTGATCTGCGATGGCTGCAATGGGCCTGTGGTAGGAACCCGCTACAAGTGCAGCGTCTG
CCCAGACTACGACTTGTGTAGCGTCTGCGAGGGAAAGGGCTTGCACCGGGGGCACACCAAGCTCGCATTCCCCAGCCCCTTCGGGCACCT
GTCTGAGGGCTTCTCGCACAGCCGCTGGCTCCGGAAGGTGAAACACGGACACTTCGGGTGGCCAGGATGGGAAATGGGTCCACCAGGAAA
CTGGAGCCCACGTCCTCCTCGTGCAGGGGAGGCCCGCCCTGGCCCCACGGCAGAATCAGCTTCTGGTCCATCGGAGGATCCGAGTGTGAA
TTTCCTGAAGAACGTTGGGGAGAGTGTGGCAGCTGCCCTTAGCCCTCTGGTTGTTCAGCACATCAAGCGACATAACATTGTTCTGAAAAG
GGAGCTAGGCGAAGGAGCCTTTGGAAAAGTGTTCCTAGCTGAATGCTATAACCTCTGTCCTGAGCAGGACAAGATCTTGGTGGCAGTGAA
GACCCTGAAGGATGCCAGTGACAATGCACGCAAGGACTTCCACCGTGAGGCCGAGCTCCTGACCAACCTCCAGCATGAGCACATCGTCAA
GTTCTATGGCGTCTGCGTGGAGGGCGACCCCCTCATCATGGTCTTTGAGTACATGAAGCATGGGGACCTCAACAAGTTCCTCAGGGCACA
CGGCCCTGATGCCGTGCTGATGGCTGAGGGCAACCCGCCCACGGAACTGACGCAGTCGCAGATGCTGCATATAGCCCAGCAGATCGCCGC
GGGCATGGTCTACCTGGCGTCCCAGCACTTCGTGCACCGCGATTTGGCCACCAGGAACTGCCTGGTCGGGGAGAACTTGCTGGTGAAAAT
CGGGGACTTTGGGATGTCCCGGGACGTGTACAGCACTGACTACTACAGGGTCGGTGGCCACACAATGCTGCCCATTCGCTGGATGCCTCC
AGAGAGCATCATGTACAGGAAATTCACGACGGAAAGCGACGTCTGGAGCCTGGGGGTCGTGTTGTGGGAGATTTTCACCTATGGCAAACA
GCCCTGGTACCAGCTGTCAAACAATGAGGTGATAGAGTGTATCACTCAGGGCCGAGTCCTGCAGCGACCCCGCACGTGCCCCCAGGAGGT
GTATGAGCTGATGCTGGGGTGCTGGCAGCGAGAGCCCCACATGAGGAAGAACATCAAGGGCATCCATACCCTCCTTCAGAACTTGGCCAA
GGCATCTCCGGTCTACCTGGACATTCTAGGCTAGGGCCCTTTTCCCCAGACCGATCCTTCCCAACGTACTCCTCAGACGGGCTGAGAGGA
TGAACATCTTTTAACTGCCGCTGGAGGCCACCAAGCTGCTCTCCTTCACTCTGACAGTATTAACATCAAAGACTCCGAGAAGCTCTCGAG
GGAAGCAGTGTGTACTTCTTCATCCATAGACACAGTATTGACTTCTTTTTGGCATTATCTCTTTCTCTCTTTCCATCTCCCTTGGTTGTT
CCTTTTTCTTTTTTTAAATTTTCTTTTTCTTTTTTTTTTCGTCTTCCCTGCTTCACGATTCTTACCCTTTCTTTTGAATCAATCTGGCTT
CTGCATTACTATTAACTCTGCATAGACAAAGGCCTTAACAAACGTAATTTGTTATATCAGCAGACACTCCAGTTTGCCCACCACAACTAA
CAATGCCTTGTTGTATTCCTGCCTTTGATGTGGATGAAAAAAAGGGAAAACAAATATTTCACTTAAACTTTGTCACTTCTGCTGTACAGA
TATCGAGAGTTTCTATGGATTCACTTCTATTTATTTATTATTATTACTGTTCTTATTGTTTTTGGATGGCTTAAGCCTGTGTATAAAAAA
GAAAACTTGTGTTCAATCTGTGAAGCCTTTATCTATGGGAGATTAAAACCAGAGAGAAAGAAGATTTATTATGAACCGCAATATGGGAGG
AACAAAGACAACCACTGGGATCAGCTGGTGTCAGTCCCTACTTAGGAAATACTCAGCAACTGTTAGCTGGGAAGAATGTATTCGGCACCT
TCCCCTGAGGACCTTTCTGAGGAGTAAAAAGACTACTGGCCTCTGTGCCATGGATGATTCTTTTCCCATCACCAGAAATGATAGCGTGCA
GTAGAGAGCAAAGATGGCTTCCGTGAGACACAAGATGGCGCATAGTGTGCTCGGACACAGTTTTGTCTTCGTAGGTTGTGATGATAGCAC
TGGTTTGTTTCTCAAGCGCTATCCACAGAACCTTTGTCAACTTCAGTTGAAAAGAGGTGGATTCATGTCCAGAGCTCATTTCGGGGTCAG
GTGGGAAAGCCAAGAACTTGGAAAAGATAAGACAAGCTATAAATTCGGAGGCAAGTTTCTTTTACAATGAACTTTTCAGATCTCACTTCC
CTCCGACCCCTAACTTCCATGCCCACCCGTCCTTTTAACTGTGCAAGCAAAATTGTGCATGGTCTTCGTCGATTAATACCTTGTGTGCAG
ACACTACTGCTCCAGACGTCGTTTCCCTGATAGGTAGAGCAGATCCATAAAAAGGTATGACTTATACAATTAGGGGAAGCTAATGGAGTT
TATTAGCTGAGTATCAATGTCTCTGCGTTGTACGGTGGTGATGGGTTTTAATGAATATGGACCCTGAAGCCTGGAAATCCTCATCCACGT
CGAACCCACAGGACTGTGGGAAGGGCAGAATCAATCCCTAAGGGAAAGGAAACCTCACCCTGAGGGCATCACATGCACTCATGTTCAGTG
TACACAGGTCAAGTCCCTTGCTCTGGGCTCTAGTTGGGAGAGTGGTTTCATTCCAAGTGTACTCCATTGTCAGTATGCTGTTTTTGTTTC
CTTCACTCCATTCAAAAAGTCAAAATACAAAATTTGGCACAGCATGCCAACGGGAGGCTGTGCCCAGACCAAGCACTGGAAGTGTGCTTC
TAGGCATAGTCATTGGTTTTGCAAAAAGAGGGCTCAAATTTAAATAGAAATTTACAGCTATTTGAATGGTCAGATATACCAAGAAAGAAA
AATATTTCTGTTCCTCAAGAAAACTTGCTACCCTCTGTGAGGGGAATTTTGCTAAACTTGACATCTTTATAACATGAGCCAGATTGAAAG
GGAGTGATTTTCATTCATCTTAGGTCATGTTATTTCATATTTGTTTCTGAAGGTGCGATAGCTCTGTTTTAGGTTTTGCTTGCGCCTGTT
AATTACTGGAACACCTTATTTTTCATTAAAGGCTTTGAAAGCCAATTCTCAAAAATTCAAAAGTGCAAATTAACAGAACAAAAGGAAATC
CAGTAGCAACTGCAGTCAAGCGAGGGAGTTGACAAGATAAACCTTACGTCCATTCAAGTTATATGCTGGCCTATGAGAGATGAGAGTTGG

>86214_86214_9_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000510187_NTRK2_chr9_87549077_ENST00000376213_length(amino acids)=545AA_BP=251
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLVVQHIKRHNIVLKRELGEG
AFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAV
LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMY
RKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVY

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>86214_86214_10_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000510187_NTRK2_chr9_87549077_ENST00000376214_length(transcript)=3807nt_BP=770nt
CAGCTCGCCGCTCGCTATGGCGTCGCTCACCGTGAAGGCCTACCTTCTGGGCAAGGAGGACGCGGCGCGCGAGATTCGCCGCTTCAGCTT
CTGCTGCAGCCCCGAGCCTGAGGCGGAAGCCGAGGCTGCGGCGGGTCCGGGACCCTGCGAGCGGCTGCTGAGCCGGGTGGCCGCCCTGTT
CCCCGCGCTGCGGCCTGGCGGCTTCCAGGCGCACTACCGCGATGAGGACGGGGACTTGGTTGCCTTTTCCAGTGACGAGGAATTGACAAT
GGCCATGTCCTACGTGAAGGATGACATCTTCCGAATCTACATTAAAGAGAAAAAAGAGTGCCGGCGGGACCACCGCCCACCGTGTGCTCA
GGAGGCGCCCCGCAACATGGTGCACCCCAATGTGATCTGCGATGGCTGCAATGGGCCTGTGGTAGGAACCCGCTACAAGTGCAGCGTCTG
CCCAGACTACGACTTGTGTAGCGTCTGCGAGGGAAAGGGCTTGCACCGGGGGCACACCAAGCTCGCATTCCCCAGCCCCTTCGGGCACCT
GTCTGAGGGCTTCTCGCACAGCCGCTGGCTCCGGAAGGTGAAACACGGACACTTCGGGTGGCCAGGATGGGAAATGGGTCCACCAGGAAA
CTGGAGCCCACGTCCTCCTCGTGCAGGGGAGGCCCGCCCTGGCCCCACGGCAGAATCAGCTTCTGGTCCATCGGAGGATCCGAGTGTGAA
TTTCCTGAAGAACGTTGGGGAGAGTGTGGCAGCTGCCCTTAGCCCTCTGGTTGTTCAGCACATCAAGCGACATAACATTGTTCTGAAAAG
GGAGCTAGGCGAAGGAGCCTTTGGAAAAGTGTTCCTAGCTGAATGCTATAACCTCTGTCCTGAGCAGGACAAGATCTTGGTGGCAGTGAA
GACCCTGAAGGATGCCAGTGACAATGCACGCAAGGACTTCCACCGTGAGGCCGAGCTCCTGACCAACCTCCAGCATGAGCACATCGTCAA
GTTCTATGGCGTCTGCGTGGAGGGCGACCCCCTCATCATGGTCTTTGAGTACATGAAGCATGGGGACCTCAACAAGTTCCTCAGGGCACA
CGGCCCTGATGCCGTGCTGATGGCTGAGGGCAACCCGCCCACGGAACTGACGCAGTCGCAGATGCTGCATATAGCCCAGCAGATCGCCGC
GGGCATGGTCTACCTGGCGTCCCAGCACTTCGTGCACCGCGATTTGGCCACCAGGAACTGCCTGGTCGGGGAGAACTTGCTGGTGAAAAT
CGGGGACTTTGGGATGTCCCGGGACGTGTACAGCACTGACTACTACAGGGTCGGTGGCCACACAATGCTGCCCATTCGCTGGATGCCTCC
AGAGAGCATCATGTACAGGAAATTCACGACGGAAAGCGACGTCTGGAGCCTGGGGGTCGTGTTGTGGGAGATTTTCACCTATGGCAAACA
GCCCTGGTACCAGCTGTCAAACAATGAGGTGATAGAGTGTATCACTCAGGGCCGAGTCCTGCAGCGACCCCGCACGTGCCCCCAGGAGGT
GTATGAGCTGATGCTGGGGTGCTGGCAGCGAGAGCCCCACATGAGGAAGAACATCAAGGGCATCCATACCCTCCTTCAGAACTTGGCCAA
GGCATCTCCGGTCTACCTGGACATTCTAGGCTAGGGCCCTTTTCCCCAGACCGATCCTTCCCAACGTACTCCTCAGACGGGCTGAGAGGA
TGAACATCTTTTAACTGCCGCTGGAGGCCACCAAGCTGCTCTCCTTCACTCTGACAGTATTAACATCAAAGACTCCGAGAAGCTCTCGAG
GGAAGCAGTGTGTACTTCTTCATCCATAGACACAGTATTGACTTCTTTTTGGCATTATCTCTTTCTCTCTTTCCATCTCCCTTGGTTGTT
CCTTTTTCTTTTTTTAAATTTTCTTTTTCTTTTTTTTTTCGTCTTCCCTGCTTCACGATTCTTACCCTTTCTTTTGAATCAATCTGGCTT
CTGCATTACTATTAACTCTGCATAGACAAAGGCCTTAACAAACGTAATTTGTTATATCAGCAGACACTCCAGTTTGCCCACCACAACTAA
CAATGCCTTGTTGTATTCCTGCCTTTGATGTGGATGAAAAAAAGGGAAAACAAATATTTCACTTAAACTTTGTCACTTCTGCTGTACAGA
TATCGAGAGTTTCTATGGATTCACTTCTATTTATTTATTATTATTACTGTTCTTATTGTTTTTGGATGGCTTAAGCCTGTGTATAAAAAA
GAAAACTTGTGTTCAATCTGTGAAGCCTTTATCTATGGGAGATTAAAACCAGAGAGAAAGAAGATTTATTATGAACCGCAATATGGGAGG
AACAAAGACAACCACTGGGATCAGCTGGTGTCAGTCCCTACTTAGGAAATACTCAGCAACTGTTAGCTGGGAAGAATGTATTCGGCACCT
TCCCCTGAGGACCTTTCTGAGGAGTAAAAAGACTACTGGCCTCTGTGCCATGGATGATTCTTTTCCCATCACCAGAAATGATAGCGTGCA
GTAGAGAGCAAAGATGGCTTCCGTGAGACACAAGATGGCGCATAGTGTGCTCGGACACAGTTTTGTCTTCGTAGGTTGTGATGATAGCAC
TGGTTTGTTTCTCAAGCGCTATCCACAGAACCTTTGTCAACTTCAGTTGAAAAGAGGTGGATTCATGTCCAGAGCTCATTTCGGGGTCAG
GTGGGAAAGCCAAGAACTTGGAAAAGATAAGACAAGCTATAAATTCGGAGGCAAGTTTCTTTTACAATGAACTTTTCAGATCTCACTTCC
CTCCGACCCCTAACTTCCATGCCCACCCGTCCTTTTAACTGTGCAAGCAAAATTGTGCATGGTCTTCGTCGATTAATACCTTGTGTGCAG
ACACTACTGCTCCAGACGTCGTTTCCCTGATAGGTAGAGCAGATCCATAAAAAGGTATGACTTATACAATTAGGGGAAGCTAATGGAGTT
TATTAGCTGAGTATCAATGTCTCTGCGTTGTACGGTGGTGATGGGTTTTAATGAATATGGACCCTGAAGCCTGGAAATCCTCATCCACGT
CGAACCCACAGGACTGTGGGAAGGGCAGAATCAATCCCTAAGGGAAAGGAAACCTCACCCTGAGGGCATCACATGCACTCATGTTCAGTG
TACACAGGTCAAGTCCCTTGCTCTGGGCTCTAGTTGGGAGAGTGGTTTCATTCCAAGTGTACTCCATTGTCAGTATGCTGTTTTTGTTTC
CTTCACTCCATTCAAAAAGTCAAAATACAAAATTTGGCACAGCATGCCAACGGGAGGCTGTGCCCAGACCAAGCACTGGAAGTGTGCTTC
TAGGCATAGTCATTGGTTTTGCAAAAAGAGGGCTCAAATTTAAATAGAAATTTACAGCTATTTGAATGGTCAGATATACCAAGAAAGAAA
AATATTTCTGTTCCTCAAGAAAACTTGCTACCCTCTGTGAGGGGAATTTTGCTAAACTTGACATCTTTATAACATGAGCCAGATTGAAAG
GGAGTGATTTTCATTCATCTTAGGTCATGTTATTTCATATTTGTTTCTGAAGGTGCGATAGCTCTGTTTTAGGTTTTGCTTGCGCCTGTT
AATTACTGGAACACCTTATTTTTCATTAAAGGCTTTGAAAGCCAATTCTCAAAAATTCAAAAGTGCAAATTAACAGAACAAAAGGAAATC
CAGTAGCAACTGCAGTCAAGCGAGGGAGTTGACAAGATAAACCTTACGTCCATTCAAGTTATATGCTGGCCTATGAGAGATGAGAGTTGG

>86214_86214_10_SQSTM1-NTRK2_SQSTM1_chr5_179252226_ENST00000510187_NTRK2_chr9_87549077_ENST00000376214_length(amino acids)=545AA_BP=251
MASLTVKAYLLGKEDAAREIRRFSFCCSPEPEAEAEAAAGPGPCERLLSRVAALFPALRPGGFQAHYRDEDGDLVAFSSDEELTMAMSYV
KDDIFRIYIKEKKECRRDHRPPCAQEAPRNMVHPNVICDGCNGPVVGTRYKCSVCPDYDLCSVCEGKGLHRGHTKLAFPSPFGHLSEGFS
HSRWLRKVKHGHFGWPGWEMGPPGNWSPRPPRAGEARPGPTAESASGPSEDPSVNFLKNVGESVAAALSPLVVQHIKRHNIVLKRELGEG
AFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAV
LMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMY
RKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVY

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SQSTM1-NTRK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000389805+58122_224251.33333333333334441.0GABRR3
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000360718+472_50167.33333333333334357.0LCK
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000376929+692_50167.33333333333334357.0LCK
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000389805+582_50251.33333333333334441.0LCK
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000402874+582_50167.33333333333334357.0LCK
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000360718+4750_80167.33333333333334357.0PAWR
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000376929+6950_80167.33333333333334357.0PAWR
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000389805+5850_80251.33333333333334441.0PAWR
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000402874+5850_80167.33333333333334357.0PAWR
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000360718+4743_107167.33333333333334357.0PRKCZ and dimerization
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000376929+6943_107167.33333333333334357.0PRKCZ and dimerization
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000389805+5843_107251.33333333333334441.0PRKCZ and dimerization
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000402874+5843_107167.33333333333334357.0PRKCZ and dimerization
TgeneNTRK2chr5:179252226chr9:87549077ENST00000304053015455_4660554.0MAPK8IP3/JIP3
TgeneNTRK2chr5:179252226chr9:87549077ENST00000359847012455_4660478.0MAPK8IP3/JIP3
TgeneNTRK2chr5:179252226chr9:87549077ENST00000376208014455_4660538.0MAPK8IP3/JIP3
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395866012455_4660322.0MAPK8IP3/JIP3
TgeneNTRK2chr5:179252226chr9:87549077ENST00000395882013455_4660478.0MAPK8IP3/JIP3


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000360718+47122_224167.33333333333334357.0GABRR3
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000376929+69122_224167.33333333333334357.0GABRR3
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000402874+58122_224167.33333333333334357.0GABRR3
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000360718+47347_352167.33333333333334357.0KEAP1
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000376929+69347_352167.33333333333334357.0KEAP1
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000389805+58347_352251.33333333333334441.0KEAP1
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000402874+58347_352167.33333333333334357.0KEAP1
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000360718+47269_440167.33333333333334357.0NTRK1
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000376929+69269_440167.33333333333334357.0NTRK1
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000389805+58269_440251.33333333333334441.0NTRK1
HgeneSQSTM1chr5:179252226chr9:87549077ENST00000402874+58269_440167.33333333333334357.0NTRK1
TgeneNTRK2chr5:179252226chr9:87549077ENST000002771201319455_466544.3333333333334839.0MAPK8IP3/JIP3
TgeneNTRK2chr5:179252226chr9:87549077ENST000003231151117455_466528.3333333333334823.0MAPK8IP3/JIP3
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762131420455_466528.3333333333334823.0MAPK8IP3/JIP3
TgeneNTRK2chr5:179252226chr9:87549077ENST000003762141521455_466544.3333333333334839.0MAPK8IP3/JIP3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SQSTM1-NTRK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SQSTM1-NTRK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource