|
||||||
|
 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:SRGAP3-RAF1 (FusionGDB2 ID:86395) |
Fusion Gene Summary for SRGAP3-RAF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SRGAP3-RAF1 | Fusion gene ID: 86395 | Hgene | Tgene | Gene symbol | SRGAP3 | RAF1 | Gene ID | 23380 | 6037 |
| Gene name | SLIT-ROBO Rho GTPase activating protein 2 | ribonuclease A family member 3 | |
| Synonyms | ARHGAP34|FNBP2|SRGAP2A|SRGAP3 | ECP|RAF1|RNS3 | |
| Cytomap | 1q32.1 | 14q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | SLIT-ROBO Rho GTPase-activating protein 2SLIT-ROBO GAP2formin-binding protein 2rho GTPase-activating protein 34 | eosinophil cationic proteinRNase 3cytotoxic ribonucleaseribonuclease 3ribonuclease, RNase A family, 3 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | P04049 | |
| Ensembl transtripts involved in fusion gene | ENST00000433332, ENST00000360413, ENST00000383836, | ENST00000251849, ENST00000442415, ENST00000534997, ENST00000542177, | |
| Fusion gene scores | * DoF score | 12 X 10 X 10=1200 | 19 X 16 X 7=2128 |
| # samples | 18 | 18 | |
| ** MAII score | log2(18/1200*10)=-2.73696559416621 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(18/2128*10)=-3.56342933917152 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SRGAP3 [Title/Abstract] AND RAF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | SRGAP3(9290737)-RAF1(12625108), # samples:1 SRGAP3(9074334)-RAF1(12641309), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | SRGAP3-RAF1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. SRGAP3-RAF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. SRGAP3-RAF1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. SRGAP3-RAF1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. SRGAP3-RAF1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. SRGAP3-RAF1 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SRGAP3 | GO:0043547 | positive regulation of GTPase activity | 21148482 |
| Hgene | SRGAP3 | GO:0046847 | filopodium assembly | 22559944 |
| Hgene | SRGAP3 | GO:0051014 | actin filament severing | 21148482 |
| Hgene | SRGAP3 | GO:0060996 | dendritic spine development | 22559944 |
| Hgene | SRGAP3 | GO:2001223 | negative regulation of neuron migration | 22559944 |
| Tgene | RAF1 | GO:0002227 | innate immune response in mucosa | 12860195 |
| Tgene | RAF1 | GO:0019731 | antibacterial humoral response | 12860195 |
| Tgene | RAF1 | GO:0043152 | induction of bacterial agglutination | 23992292 |
| Tgene | RAF1 | GO:0045087 | innate immune response | 23992292 |
| Tgene | RAF1 | GO:0050829 | defense response to Gram-negative bacterium | 23992292 |
| Tgene | RAF1 | GO:0050830 | defense response to Gram-positive bacterium | 12860195|23992292 |
| Tgene | RAF1 | GO:0061844 | antimicrobial humoral immune response mediated by antimicrobial peptide | 12860195 |
| Fusion gene breakpoints across SRGAP3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across RAF1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | astrocytoma | FM209427 | SRGAP3 | chr3 | 9290737 | RAF1 | chr3 | 12625108 | ||
| ChimerKB3 | . | . | SRGAP3 | chr3 | 9079746 | - | RAF1 | chr3 | 12641914 | - |
| ChimerKB3 | . | . | SRGAP3 | chr3 | 9290737 | - | RAF1 | chr3 | 12625108 | - |
| ChiTaRS5.0 | N/A | FM209427 | SRGAP3 | chr3 | 9074334 | - | RAF1 | chr3 | 12641309 | - |
Top |
Fusion Gene ORF analysis for SRGAP3-RAF1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000433332 | ENST00000251849 | SRGAP3 | chr3 | 9079746 | - | RAF1 | chr3 | 12641914 | - |
| 5UTR-3CDS | ENST00000433332 | ENST00000251849 | SRGAP3 | chr3 | 9074334 | - | RAF1 | chr3 | 12641309 | - |
| 5UTR-3CDS | ENST00000433332 | ENST00000442415 | SRGAP3 | chr3 | 9079746 | - | RAF1 | chr3 | 12641914 | - |
| 5UTR-3CDS | ENST00000433332 | ENST00000442415 | SRGAP3 | chr3 | 9074334 | - | RAF1 | chr3 | 12641309 | - |
| 5UTR-3CDS | ENST00000433332 | ENST00000534997 | SRGAP3 | chr3 | 9079746 | - | RAF1 | chr3 | 12641914 | - |
| 5UTR-3CDS | ENST00000433332 | ENST00000534997 | SRGAP3 | chr3 | 9074334 | - | RAF1 | chr3 | 12641309 | - |
| 5UTR-3CDS | ENST00000433332 | ENST00000542177 | SRGAP3 | chr3 | 9079746 | - | RAF1 | chr3 | 12641914 | - |
| 5UTR-3CDS | ENST00000433332 | ENST00000542177 | SRGAP3 | chr3 | 9074334 | - | RAF1 | chr3 | 12641309 | - |
| Frame-shift | ENST00000360413 | ENST00000251849 | SRGAP3 | chr3 | 9079746 | - | RAF1 | chr3 | 12641914 | - |
| Frame-shift | ENST00000360413 | ENST00000442415 | SRGAP3 | chr3 | 9079746 | - | RAF1 | chr3 | 12641914 | - |
| Frame-shift | ENST00000360413 | ENST00000534997 | SRGAP3 | chr3 | 9079746 | - | RAF1 | chr3 | 12641914 | - |
| Frame-shift | ENST00000360413 | ENST00000542177 | SRGAP3 | chr3 | 9079746 | - | RAF1 | chr3 | 12641914 | - |
| Frame-shift | ENST00000383836 | ENST00000251849 | SRGAP3 | chr3 | 9079746 | - | RAF1 | chr3 | 12641914 | - |
| Frame-shift | ENST00000383836 | ENST00000442415 | SRGAP3 | chr3 | 9079746 | - | RAF1 | chr3 | 12641914 | - |
| Frame-shift | ENST00000383836 | ENST00000534997 | SRGAP3 | chr3 | 9079746 | - | RAF1 | chr3 | 12641914 | - |
| Frame-shift | ENST00000383836 | ENST00000542177 | SRGAP3 | chr3 | 9079746 | - | RAF1 | chr3 | 12641914 | - |
| In-frame | ENST00000383836 | ENST00000251849 | SRGAP3 | chr3 | 9074334 | - | RAF1 | chr3 | 12641309 | - |
| In-frame | ENST00000383836 | ENST00000442415 | SRGAP3 | chr3 | 9074334 | - | RAF1 | chr3 | 12641309 | - |
| In-frame | ENST00000383836 | ENST00000534997 | SRGAP3 | chr3 | 9074334 | - | RAF1 | chr3 | 12641309 | - |
| In-frame | ENST00000383836 | ENST00000542177 | SRGAP3 | chr3 | 9074334 | - | RAF1 | chr3 | 12641309 | - |
| intron-3CDS | ENST00000360413 | ENST00000251849 | SRGAP3 | chr3 | 9074334 | - | RAF1 | chr3 | 12641309 | - |
| intron-3CDS | ENST00000360413 | ENST00000442415 | SRGAP3 | chr3 | 9074334 | - | RAF1 | chr3 | 12641309 | - |
| intron-3CDS | ENST00000360413 | ENST00000534997 | SRGAP3 | chr3 | 9074334 | - | RAF1 | chr3 | 12641309 | - |
| intron-3CDS | ENST00000360413 | ENST00000542177 | SRGAP3 | chr3 | 9074334 | - | RAF1 | chr3 | 12641309 | - |
| intron-3UTR | ENST00000360413 | ENST00000251849 | SRGAP3 | chr3 | 9290737 | RAF1 | chr3 | 12625108 | ||
| intron-3UTR | ENST00000360413 | ENST00000251849 | SRGAP3 | chr3 | 9290737 | - | RAF1 | chr3 | 12625108 | - |
| intron-3UTR | ENST00000383836 | ENST00000251849 | SRGAP3 | chr3 | 9290737 | RAF1 | chr3 | 12625108 | ||
| intron-3UTR | ENST00000383836 | ENST00000251849 | SRGAP3 | chr3 | 9290737 | - | RAF1 | chr3 | 12625108 | - |
| intron-3UTR | ENST00000433332 | ENST00000251849 | SRGAP3 | chr3 | 9290737 | RAF1 | chr3 | 12625108 | ||
| intron-3UTR | ENST00000433332 | ENST00000251849 | SRGAP3 | chr3 | 9290737 | - | RAF1 | chr3 | 12625108 | - |
| intron-intron | ENST00000360413 | ENST00000442415 | SRGAP3 | chr3 | 9290737 | RAF1 | chr3 | 12625108 | ||
| intron-intron | ENST00000360413 | ENST00000442415 | SRGAP3 | chr3 | 9290737 | - | RAF1 | chr3 | 12625108 | - |
| intron-intron | ENST00000360413 | ENST00000534997 | SRGAP3 | chr3 | 9290737 | RAF1 | chr3 | 12625108 | ||
| intron-intron | ENST00000360413 | ENST00000534997 | SRGAP3 | chr3 | 9290737 | - | RAF1 | chr3 | 12625108 | - |
| intron-intron | ENST00000360413 | ENST00000542177 | SRGAP3 | chr3 | 9290737 | RAF1 | chr3 | 12625108 | ||
| intron-intron | ENST00000360413 | ENST00000542177 | SRGAP3 | chr3 | 9290737 | - | RAF1 | chr3 | 12625108 | - |
| intron-intron | ENST00000383836 | ENST00000442415 | SRGAP3 | chr3 | 9290737 | RAF1 | chr3 | 12625108 | ||
| intron-intron | ENST00000383836 | ENST00000442415 | SRGAP3 | chr3 | 9290737 | - | RAF1 | chr3 | 12625108 | - |
| intron-intron | ENST00000383836 | ENST00000534997 | SRGAP3 | chr3 | 9290737 | RAF1 | chr3 | 12625108 | ||
| intron-intron | ENST00000383836 | ENST00000534997 | SRGAP3 | chr3 | 9290737 | - | RAF1 | chr3 | 12625108 | - |
| intron-intron | ENST00000383836 | ENST00000542177 | SRGAP3 | chr3 | 9290737 | RAF1 | chr3 | 12625108 | ||
| intron-intron | ENST00000383836 | ENST00000542177 | SRGAP3 | chr3 | 9290737 | - | RAF1 | chr3 | 12625108 | - |
| intron-intron | ENST00000433332 | ENST00000442415 | SRGAP3 | chr3 | 9290737 | RAF1 | chr3 | 12625108 | ||
| intron-intron | ENST00000433332 | ENST00000442415 | SRGAP3 | chr3 | 9290737 | - | RAF1 | chr3 | 12625108 | - |
| intron-intron | ENST00000433332 | ENST00000534997 | SRGAP3 | chr3 | 9290737 | RAF1 | chr3 | 12625108 | ||
| intron-intron | ENST00000433332 | ENST00000534997 | SRGAP3 | chr3 | 9290737 | - | RAF1 | chr3 | 12625108 | - |
| intron-intron | ENST00000433332 | ENST00000542177 | SRGAP3 | chr3 | 9290737 | RAF1 | chr3 | 12625108 | ||
| intron-intron | ENST00000433332 | ENST00000542177 | SRGAP3 | chr3 | 9290737 | - | RAF1 | chr3 | 12625108 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000383836 | SRGAP3 | chr3 | 9074334 | - | ENST00000251849 | RAF1 | chr3 | 12641309 | - | 3837 | 1967 | 338 | 2923 | 861 |
| ENST00000383836 | SRGAP3 | chr3 | 9074334 | - | ENST00000442415 | RAF1 | chr3 | 12641309 | - | 3640 | 1967 | 338 | 2923 | 861 |
| ENST00000383836 | SRGAP3 | chr3 | 9074334 | - | ENST00000534997 | RAF1 | chr3 | 12641309 | - | 3171 | 1967 | 338 | 2923 | 861 |
| ENST00000383836 | SRGAP3 | chr3 | 9074334 | - | ENST00000542177 | RAF1 | chr3 | 12641309 | - | 3105 | 1967 | 338 | 2923 | 861 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000383836 | ENST00000251849 | SRGAP3 | chr3 | 9074334 | - | RAF1 | chr3 | 12641309 | - | 0.002971599 | 0.9970284 |
| ENST00000383836 | ENST00000442415 | SRGAP3 | chr3 | 9074334 | - | RAF1 | chr3 | 12641309 | - | 0.004686819 | 0.99531317 |
| ENST00000383836 | ENST00000534997 | SRGAP3 | chr3 | 9074334 | - | RAF1 | chr3 | 12641309 | - | 0.004399666 | 0.99560034 |
| ENST00000383836 | ENST00000542177 | SRGAP3 | chr3 | 9074334 | - | RAF1 | chr3 | 12641309 | - | 0.004502535 | 0.99549747 |
Top |
Fusion Genomic Features for SRGAP3-RAF1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
Top |
Fusion Protein Features for SRGAP3-RAF1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:9290737/chr3:12625108) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | RAF1 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2). The phosphorylated form of RAF1 (on residues Ser-338 and Ser-339, by PAK1) phosphorylates BAD/Bcl2-antagonist of cell death at 'Ser-75'. Phosphorylates adenylyl cyclases: ADCY2, ADCY5 and ADCY6, resulting in their activation. Phosphorylates PPP1R12A resulting in inhibition of the phosphatase activity. Phosphorylates TNNT2/cardiac muscle troponin T. Can promote NF-kB activation and inhibit signal transducers involved in motility (ROCK2), apoptosis (MAP3K5/ASK1 and STK3/MST2), proliferation and angiogenesis (RB1). Can protect cells from apoptosis also by translocating to the mitochondria where it binds BCL2 and displaces BAD/Bcl2-antagonist of cell death. Regulates Rho signaling and migration, and is required for normal wound healing. Plays a role in the oncogenic transformation of epithelial cells via repression of the TJ protein, occludin (OCLN) by inducing the up-regulation of a transcriptional repressor SNAI2/SLUG, which induces down-regulation of OCLN. Restricts caspase activation in response to selected stimuli, notably Fas stimulation, pathogen-mediated macrophage apoptosis, and erythroid differentiation. {ECO:0000269|PubMed:11427728, ECO:0000269|PubMed:11719507, ECO:0000269|PubMed:15385642, ECO:0000269|PubMed:15618521, ECO:0000269|PubMed:15849194, ECO:0000269|PubMed:16892053, ECO:0000269|PubMed:16924233, ECO:0000269|PubMed:9360956}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SRGAP3 | chr3:9074334 | chr3:12641309 | ENST00000383836 | - | 12 | 22 | 352_392 | 513 | 1100.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SRGAP3 | chr3:9074334 | chr3:12641309 | ENST00000383836 | - | 12 | 22 | 19_314 | 513 | 1100.0 | Domain | F-BAR |
| Tgene | RAF1 | chr3:9074334 | chr3:12641309 | ENST00000251849 | 8 | 17 | 349_609 | 330 | 649.0 | Domain | Protein kinase | |
| Tgene | RAF1 | chr3:9074334 | chr3:12641309 | ENST00000442415 | 9 | 18 | 349_609 | 350 | 669.0 | Domain | Protein kinase | |
| Tgene | RAF1 | chr3:9074334 | chr3:12641309 | ENST00000251849 | 8 | 17 | 355_363 | 330 | 649.0 | Nucleotide binding | ATP | |
| Tgene | RAF1 | chr3:9074334 | chr3:12641309 | ENST00000442415 | 9 | 18 | 355_363 | 350 | 669.0 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | SRGAP3 | chr3:9074334 | chr3:12641309 | ENST00000360413 | - | 1 | 22 | 352_392 | 0 | 1076.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SRGAP3 | chr3:9074334 | chr3:12641309 | ENST00000360413 | - | 1 | 22 | 952_987 | 0 | 1076.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SRGAP3 | chr3:9074334 | chr3:12641309 | ENST00000383836 | - | 12 | 22 | 952_987 | 513 | 1100.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | SRGAP3 | chr3:9074334 | chr3:12641309 | ENST00000360413 | - | 1 | 22 | 19_314 | 0 | 1076.0 | Domain | F-BAR |
| Hgene | SRGAP3 | chr3:9074334 | chr3:12641309 | ENST00000360413 | - | 1 | 22 | 482_670 | 0 | 1076.0 | Domain | Rho-GAP |
| Hgene | SRGAP3 | chr3:9074334 | chr3:12641309 | ENST00000360413 | - | 1 | 22 | 744_803 | 0 | 1076.0 | Domain | SH3 |
| Hgene | SRGAP3 | chr3:9074334 | chr3:12641309 | ENST00000383836 | - | 12 | 22 | 482_670 | 513 | 1100.0 | Domain | Rho-GAP |
| Hgene | SRGAP3 | chr3:9074334 | chr3:12641309 | ENST00000383836 | - | 12 | 22 | 744_803 | 513 | 1100.0 | Domain | SH3 |
| Tgene | RAF1 | chr3:9074334 | chr3:12641309 | ENST00000251849 | 8 | 17 | 56_131 | 330 | 649.0 | Domain | RBD | |
| Tgene | RAF1 | chr3:9074334 | chr3:12641309 | ENST00000442415 | 9 | 18 | 56_131 | 350 | 669.0 | Domain | RBD | |
| Tgene | RAF1 | chr3:9074334 | chr3:12641309 | ENST00000251849 | 8 | 17 | 138_184 | 330 | 649.0 | Zinc finger | Phorbol-ester/DAG-type | |
| Tgene | RAF1 | chr3:9074334 | chr3:12641309 | ENST00000442415 | 9 | 18 | 138_184 | 350 | 669.0 | Zinc finger | Phorbol-ester/DAG-type |
Top |
Fusion Gene Sequence for SRGAP3-RAF1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >86395_86395_1_SRGAP3-RAF1_SRGAP3_chr3_9074334_ENST00000383836_RAF1_chr3_12641309_ENST00000251849_length(transcript)=3837nt_BP=1967nt GTGTGTGTGTATGCCTGTGTGCACAGCACAACTGTGTGCGTGTCCCGGTGAGTGTGCCTGTGCATGCGTGAGTGTGTGTACGTGTGCATG TGTGTGTGAGTGCGCTTGGTTATTACTATTATTATTATTTTTGGAAGAAAAATCTTTGAAAATCTGGGGCAGGTTACTGTGCTCCTAGGG TGATTCTTCTTTTGCAAGAGGAGCTGACCAGGGCAAGCTACTAGAGCCATTTCTCGGCAAGTAAAGAGATTTTTCCTTCCAGAAGGAGAA GGATTTTTCTCCCTGCTCTGCAGCCAAGTGAAAGAGATTAGTCCCTAAACCTGTGAAATCGACCAGAGCTGTGTGATTACCAGGGCTTGA GAGAGGACTCGAAAAGAAAAGGAGAAATAAATCAAACAGCCTGTCAGTTCCTTTGGCCACGTCAGAAGATGTCATCTCAAACTAAGTTCA AGAAAGACAAAGAGATCATTGCTGAATATGAAGCCCAAATAAAAGAGATCCGCACGCAGCTGGTGGAGCAGTTCAAATGTCTGGAGCAGC AATCAGAGTCGCGACTGCAGCTGCTTCAAGACCTCCAGGAGTTTTTCCGCCGGAAAGCTGAGATTGAGCTCGAGTACTCCCGCAGCCTGG AGAAGCTGGCTGAGCGCTTCTCCTCCAAAATCCGCAGCTCCCGGGAGCACCAGTTCAAGAAGGACCAGTACCTCCTCTCGCCTGTGAACT GTTGGTATCTGGTTCTGCATCAGACCCGGCGGGAGAGCCGAGACCATGCCACCCTCAATGACATCTTCATGAACAATGTCATCGTCCGCC TCTCCCAGATCAGTGAGGATGTCATCAGACTCTTCAAAAAGAGCAAGGAGATTGGCCTGCAGATGCACGAGGAGCTCCTGAAGGTGACCA ATGAGCTCTACACAGTCATGAAAACCTACCACATGTACCATGCAGAGAGCATCAGTGCGGAAAGCAAGCTGAAGGAGGCTGAGAAGCAGG AGGAGAAGCAGTTCAATAAGTCAGGAGACCTCAGCATGAACCTGCTCCGGCACGAGGACCGGCCCCAGCGCCGCAGCTCTGTGAAGAAGA TTGAGAAGATGAAGGAGAAGAGGCAGGCCAAGTACTCTGAGAACAAGCTGAAATGCACAAAGGCCCGGAATGACTACTTGCTCAATCTGG CAGCCACCAACGCAGCTATAAGCAAATACTACATCCATGATGTCTCTGATCTGATCGATTGCTGTGATTTGGGCTTCCATGCCAGCCTGG CCCGCACCTTCCGGACCTATCTCTCAGCTGAATACAACCTGGAGACCTCTCGCCACGAAGGGCTGGATGTCATTGAGAATGCAGTGGACA ACCTGGATTCCCGAAGTGACAAGCACACAGTCATGGACATGTGCAATCAAGTCTTCTGCCCTCCACTCAAGTTCGAGTTCCAGCCCCACA TGGGGGATGAGGTCTGCCAGGTCAGCGCTCAGCAGCCCGTCCAGACAGAACTGCTCATGCGTTATCACCAGCTGCAGTCCAGACTGGCCA CCCTCAAGATAGAGAATGAGGAGGTTAGGAAAACCCTGGATGCCACCATGCAGACATTACAGGACATGCTGACTGTGGAGGACTTTGATG TCTCCGATGCCTTCCAACACAGTCGATCGACAGAGTCCGTCAAGTCGGCTGCCTCTGAGACCTACATGAGCAAGATCAACATTGCCAAGA GGAGAGCCAACCAGCAGGAAACAGAAATGTTTTATTTTACAAAATTTAAAGAGTATGTGAATGGCAGTAACCTCATCACCAAGCTGCAGG CCAAGCACGATTTACTCAAGCAGACCCTGGGCGAAGGGGAAAGAGCAGAATGCGGCACCACCAGGCCCCCCTGTCTTCCCCCTAAACCAC AGAAAATGAGGAGACCTAGGCCTCTCTCAGTGTATAGCCATAAACTCTTTAACGGCAGTATGGAAGCATTCATTAAGAGGCCTCGTGGAC AGAGAGATTCAAGCTATTATTGGGAAATAGAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATA AGGGTAAATGGCACGGAGATGTTGCAGTAAAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGG CTGTTCTGCGCAAAACACGGCATGTGAACATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCG AGGGCAGCAGCCTCTACAAACACCTGCATGTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGG GAATGGACTATTTGCATGCAAAGAACATCATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTG GAGATTTTGGTTTGGCAACAGTAAAGTCACGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAG AGGTGATCCGAATGCAGGATAACAACCCATTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGG AGCTTCCTTATTCTCACATCAACAACCGAGATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATA AGAACTGCCCCAAAGCAATGAAGAGGCTGGTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTT CCATTGAGCTGCTCCAACACTCTCTACCGAAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCA ATGCTTGCACGCTGACCACGTCCCCGAGGCTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCC AGCAGGCACCACTTTTCTGCTCCCTTTCTCCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACA GGGCCTTAACTTCATGTTGCCTTCTTTTCTATCCCTTTGGGCCCTGGGAGAAGGAAGCCATTTGCAGTGCTGGTGTGTCCTGCTCCCTCC CCACATTCCCCATGCTCAAGGCCCAGCCTTCTGTAGATGCGCAAGTGGATGTTGATGGTAGTACAAAAAGCAGGGGCCCAGCCCCAGCTG TTGGCTACATGAGTATTTAGAGGAAGTAAGGTAGCAGGCAGTCCAGCCCTGATGTGGAGACACATGGGATTTTGGAAATCAGCTTCTGGA GGAATGCATGTCACAGGCGGGACTTTCTTCAGAGAGTGGTGCAGCGCCAGACATTTTGCACATAAGGCACCAAACAGCCCAGGACTGCCG AGACTCTGGCCGCCCGAAGGAGCCTGCTTTGGTACTATGGAACTTTTCTTAGGGGACACGTCCTCCTTTCACAGCTTCTAAGGTGTCCAG TGCATTGGGATGGTTTTCCAGGCAAGGCACTCGGCCAATCCGCATCTCAGCCCTCTCAGGGAGCAGTCTTCCATCATGCTGAATTTTGTC TTCCAGGAGCTGCCCCTATGGGGCGGGGCCGCAGGGCCAGCCTTGTTTCTCTAACAAACAAACAAACAAACAGCCTTGTTTCTCTAGTCA CATCATGTGTATACAAGGAAGCCAGGAATACAGGTTTTCTTGATGATTTGGGTTTTAATTTTGTTTTTATTGCACCTGACAAAATACAGT >86395_86395_1_SRGAP3-RAF1_SRGAP3_chr3_9074334_ENST00000383836_RAF1_chr3_12641309_ENST00000251849_length(amino acids)=861AA_BP=543 MCDYQGLREDSKRKGEINQTACQFLWPRQKMSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKKSKEIGLQMH EELLKVTNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKAR NDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPL KFEFQPHMGDEVCQVSAQQPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYM SKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRPPCLPPKPQKMRRPRPLSVYSHKLFNGSMEA FIKRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNL AIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTG SVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERP -------------------------------------------------------------- >86395_86395_2_SRGAP3-RAF1_SRGAP3_chr3_9074334_ENST00000383836_RAF1_chr3_12641309_ENST00000442415_length(transcript)=3640nt_BP=1967nt GTGTGTGTGTATGCCTGTGTGCACAGCACAACTGTGTGCGTGTCCCGGTGAGTGTGCCTGTGCATGCGTGAGTGTGTGTACGTGTGCATG TGTGTGTGAGTGCGCTTGGTTATTACTATTATTATTATTTTTGGAAGAAAAATCTTTGAAAATCTGGGGCAGGTTACTGTGCTCCTAGGG TGATTCTTCTTTTGCAAGAGGAGCTGACCAGGGCAAGCTACTAGAGCCATTTCTCGGCAAGTAAAGAGATTTTTCCTTCCAGAAGGAGAA GGATTTTTCTCCCTGCTCTGCAGCCAAGTGAAAGAGATTAGTCCCTAAACCTGTGAAATCGACCAGAGCTGTGTGATTACCAGGGCTTGA GAGAGGACTCGAAAAGAAAAGGAGAAATAAATCAAACAGCCTGTCAGTTCCTTTGGCCACGTCAGAAGATGTCATCTCAAACTAAGTTCA AGAAAGACAAAGAGATCATTGCTGAATATGAAGCCCAAATAAAAGAGATCCGCACGCAGCTGGTGGAGCAGTTCAAATGTCTGGAGCAGC AATCAGAGTCGCGACTGCAGCTGCTTCAAGACCTCCAGGAGTTTTTCCGCCGGAAAGCTGAGATTGAGCTCGAGTACTCCCGCAGCCTGG AGAAGCTGGCTGAGCGCTTCTCCTCCAAAATCCGCAGCTCCCGGGAGCACCAGTTCAAGAAGGACCAGTACCTCCTCTCGCCTGTGAACT GTTGGTATCTGGTTCTGCATCAGACCCGGCGGGAGAGCCGAGACCATGCCACCCTCAATGACATCTTCATGAACAATGTCATCGTCCGCC TCTCCCAGATCAGTGAGGATGTCATCAGACTCTTCAAAAAGAGCAAGGAGATTGGCCTGCAGATGCACGAGGAGCTCCTGAAGGTGACCA ATGAGCTCTACACAGTCATGAAAACCTACCACATGTACCATGCAGAGAGCATCAGTGCGGAAAGCAAGCTGAAGGAGGCTGAGAAGCAGG AGGAGAAGCAGTTCAATAAGTCAGGAGACCTCAGCATGAACCTGCTCCGGCACGAGGACCGGCCCCAGCGCCGCAGCTCTGTGAAGAAGA TTGAGAAGATGAAGGAGAAGAGGCAGGCCAAGTACTCTGAGAACAAGCTGAAATGCACAAAGGCCCGGAATGACTACTTGCTCAATCTGG CAGCCACCAACGCAGCTATAAGCAAATACTACATCCATGATGTCTCTGATCTGATCGATTGCTGTGATTTGGGCTTCCATGCCAGCCTGG CCCGCACCTTCCGGACCTATCTCTCAGCTGAATACAACCTGGAGACCTCTCGCCACGAAGGGCTGGATGTCATTGAGAATGCAGTGGACA ACCTGGATTCCCGAAGTGACAAGCACACAGTCATGGACATGTGCAATCAAGTCTTCTGCCCTCCACTCAAGTTCGAGTTCCAGCCCCACA TGGGGGATGAGGTCTGCCAGGTCAGCGCTCAGCAGCCCGTCCAGACAGAACTGCTCATGCGTTATCACCAGCTGCAGTCCAGACTGGCCA CCCTCAAGATAGAGAATGAGGAGGTTAGGAAAACCCTGGATGCCACCATGCAGACATTACAGGACATGCTGACTGTGGAGGACTTTGATG TCTCCGATGCCTTCCAACACAGTCGATCGACAGAGTCCGTCAAGTCGGCTGCCTCTGAGACCTACATGAGCAAGATCAACATTGCCAAGA GGAGAGCCAACCAGCAGGAAACAGAAATGTTTTATTTTACAAAATTTAAAGAGTATGTGAATGGCAGTAACCTCATCACCAAGCTGCAGG CCAAGCACGATTTACTCAAGCAGACCCTGGGCGAAGGGGAAAGAGCAGAATGCGGCACCACCAGGCCCCCCTGTCTTCCCCCTAAACCAC AGAAAATGAGGAGACCTAGGCCTCTCTCAGTGTATAGCCATAAACTCTTTAACGGCAGTATGGAAGCATTCATTAAGAGGCCTCGTGGAC AGAGAGATTCAAGCTATTATTGGGAAATAGAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATA AGGGTAAATGGCACGGAGATGTTGCAGTAAAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGG CTGTTCTGCGCAAAACACGGCATGTGAACATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCG AGGGCAGCAGCCTCTACAAACACCTGCATGTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGG GAATGGACTATTTGCATGCAAAGAACATCATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTG GAGATTTTGGTTTGGCAACAGTAAAGTCACGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAG AGGTGATCCGAATGCAGGATAACAACCCATTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGG AGCTTCCTTATTCTCACATCAACAACCGAGATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATA AGAACTGCCCCAAAGCAATGAAGAGGCTGGTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTT CCATTGAGCTGCTCCAACACTCTCTACCGAAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCA ATGCTTGCACGCTGACCACGTCCCCGAGGCTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCC AGCAGGCACCACTTTTCTGCTCCCTTTCTCCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACA GGGCCTTAACTTCATGTTGCCTTCTTTTCTATCCCTTTGGGCCCTGGGAGAAGGAAGCCATTTGCAGTGCTGGTGTGTCCTGCTCCCTCC CCACATTCCCCATGCTCAAGGCCCAGCCTTCTGTAGATGCGCAAGTGGATGTTGATGGTAGTACAAAAAGCAGGGGCCCAGCCCCAGCTG TTGGCTACATGAGTATTTAGAGGAAGTAAGGTAGCAGGCAGTCCAGCCCTGATGTGGAGACACATGGGATTTTGGAAATCAGCTTCTGGA GGAATGCATGTCACAGGCGGGACTTTCTTCAGAGAGTGGTGCAGCGCCAGACATTTTGCACATAAGGCACCAAACAGCCCAGGACTGCCG AGACTCTGGCCGCCCGAAGGAGCCTGCTTTGGTACTATGGAACTTTTCTTAGGGGACACGTCCTCCTTTCACAGCTTCTAAGGTGTCCAG TGCATTGGGATGGTTTTCCAGGCAAGGCACTCGGCCAATCCGCATCTCAGCCCTCTCAGGGAGCAGTCTTCCATCATGCTGAATTTTGTC >86395_86395_2_SRGAP3-RAF1_SRGAP3_chr3_9074334_ENST00000383836_RAF1_chr3_12641309_ENST00000442415_length(amino acids)=861AA_BP=543 MCDYQGLREDSKRKGEINQTACQFLWPRQKMSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKKSKEIGLQMH EELLKVTNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKAR NDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPL KFEFQPHMGDEVCQVSAQQPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYM SKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRPPCLPPKPQKMRRPRPLSVYSHKLFNGSMEA FIKRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNL AIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTG SVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERP -------------------------------------------------------------- >86395_86395_3_SRGAP3-RAF1_SRGAP3_chr3_9074334_ENST00000383836_RAF1_chr3_12641309_ENST00000534997_length(transcript)=3171nt_BP=1967nt GTGTGTGTGTATGCCTGTGTGCACAGCACAACTGTGTGCGTGTCCCGGTGAGTGTGCCTGTGCATGCGTGAGTGTGTGTACGTGTGCATG TGTGTGTGAGTGCGCTTGGTTATTACTATTATTATTATTTTTGGAAGAAAAATCTTTGAAAATCTGGGGCAGGTTACTGTGCTCCTAGGG TGATTCTTCTTTTGCAAGAGGAGCTGACCAGGGCAAGCTACTAGAGCCATTTCTCGGCAAGTAAAGAGATTTTTCCTTCCAGAAGGAGAA GGATTTTTCTCCCTGCTCTGCAGCCAAGTGAAAGAGATTAGTCCCTAAACCTGTGAAATCGACCAGAGCTGTGTGATTACCAGGGCTTGA GAGAGGACTCGAAAAGAAAAGGAGAAATAAATCAAACAGCCTGTCAGTTCCTTTGGCCACGTCAGAAGATGTCATCTCAAACTAAGTTCA AGAAAGACAAAGAGATCATTGCTGAATATGAAGCCCAAATAAAAGAGATCCGCACGCAGCTGGTGGAGCAGTTCAAATGTCTGGAGCAGC AATCAGAGTCGCGACTGCAGCTGCTTCAAGACCTCCAGGAGTTTTTCCGCCGGAAAGCTGAGATTGAGCTCGAGTACTCCCGCAGCCTGG AGAAGCTGGCTGAGCGCTTCTCCTCCAAAATCCGCAGCTCCCGGGAGCACCAGTTCAAGAAGGACCAGTACCTCCTCTCGCCTGTGAACT GTTGGTATCTGGTTCTGCATCAGACCCGGCGGGAGAGCCGAGACCATGCCACCCTCAATGACATCTTCATGAACAATGTCATCGTCCGCC TCTCCCAGATCAGTGAGGATGTCATCAGACTCTTCAAAAAGAGCAAGGAGATTGGCCTGCAGATGCACGAGGAGCTCCTGAAGGTGACCA ATGAGCTCTACACAGTCATGAAAACCTACCACATGTACCATGCAGAGAGCATCAGTGCGGAAAGCAAGCTGAAGGAGGCTGAGAAGCAGG AGGAGAAGCAGTTCAATAAGTCAGGAGACCTCAGCATGAACCTGCTCCGGCACGAGGACCGGCCCCAGCGCCGCAGCTCTGTGAAGAAGA TTGAGAAGATGAAGGAGAAGAGGCAGGCCAAGTACTCTGAGAACAAGCTGAAATGCACAAAGGCCCGGAATGACTACTTGCTCAATCTGG CAGCCACCAACGCAGCTATAAGCAAATACTACATCCATGATGTCTCTGATCTGATCGATTGCTGTGATTTGGGCTTCCATGCCAGCCTGG CCCGCACCTTCCGGACCTATCTCTCAGCTGAATACAACCTGGAGACCTCTCGCCACGAAGGGCTGGATGTCATTGAGAATGCAGTGGACA ACCTGGATTCCCGAAGTGACAAGCACACAGTCATGGACATGTGCAATCAAGTCTTCTGCCCTCCACTCAAGTTCGAGTTCCAGCCCCACA TGGGGGATGAGGTCTGCCAGGTCAGCGCTCAGCAGCCCGTCCAGACAGAACTGCTCATGCGTTATCACCAGCTGCAGTCCAGACTGGCCA CCCTCAAGATAGAGAATGAGGAGGTTAGGAAAACCCTGGATGCCACCATGCAGACATTACAGGACATGCTGACTGTGGAGGACTTTGATG TCTCCGATGCCTTCCAACACAGTCGATCGACAGAGTCCGTCAAGTCGGCTGCCTCTGAGACCTACATGAGCAAGATCAACATTGCCAAGA GGAGAGCCAACCAGCAGGAAACAGAAATGTTTTATTTTACAAAATTTAAAGAGTATGTGAATGGCAGTAACCTCATCACCAAGCTGCAGG CCAAGCACGATTTACTCAAGCAGACCCTGGGCGAAGGGGAAAGAGCAGAATGCGGCACCACCAGGCCCCCCTGTCTTCCCCCTAAACCAC AGAAAATGAGGAGACCTAGGCCTCTCTCAGTGTATAGCCATAAACTCTTTAACGGCAGTATGGAAGCATTCATTAAGAGGCCTCGTGGAC AGAGAGATTCAAGCTATTATTGGGAAATAGAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATA AGGGTAAATGGCACGGAGATGTTGCAGTAAAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGG CTGTTCTGCGCAAAACACGGCATGTGAACATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCG AGGGCAGCAGCCTCTACAAACACCTGCATGTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGG GAATGGACTATTTGCATGCAAAGAACATCATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTG GAGATTTTGGTTTGGCAACAGTAAAGTCACGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAG AGGTGATCCGAATGCAGGATAACAACCCATTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGG AGCTTCCTTATTCTCACATCAACAACCGAGATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATA AGAACTGCCCCAAAGCAATGAAGAGGCTGGTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTT CCATTGAGCTGCTCCAACACTCTCTACCGAAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCA ATGCTTGCACGCTGACCACGTCCCCGAGGCTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCC AGCAGGCACCACTTTTCTGCTCCCTTTCTCCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACA GGGCCTTAACTTCATGTTGCCTTCTTTTCTATCCCTTTGGGCCCTGGGAGAAGGAAGCCATTTGCAGTGCTGGTGTGTCCTGCTCCCTCC >86395_86395_3_SRGAP3-RAF1_SRGAP3_chr3_9074334_ENST00000383836_RAF1_chr3_12641309_ENST00000534997_length(amino acids)=861AA_BP=543 MCDYQGLREDSKRKGEINQTACQFLWPRQKMSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKKSKEIGLQMH EELLKVTNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKAR NDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPL KFEFQPHMGDEVCQVSAQQPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYM SKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRPPCLPPKPQKMRRPRPLSVYSHKLFNGSMEA FIKRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNL AIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTG SVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERP -------------------------------------------------------------- >86395_86395_4_SRGAP3-RAF1_SRGAP3_chr3_9074334_ENST00000383836_RAF1_chr3_12641309_ENST00000542177_length(transcript)=3105nt_BP=1967nt GTGTGTGTGTATGCCTGTGTGCACAGCACAACTGTGTGCGTGTCCCGGTGAGTGTGCCTGTGCATGCGTGAGTGTGTGTACGTGTGCATG TGTGTGTGAGTGCGCTTGGTTATTACTATTATTATTATTTTTGGAAGAAAAATCTTTGAAAATCTGGGGCAGGTTACTGTGCTCCTAGGG TGATTCTTCTTTTGCAAGAGGAGCTGACCAGGGCAAGCTACTAGAGCCATTTCTCGGCAAGTAAAGAGATTTTTCCTTCCAGAAGGAGAA GGATTTTTCTCCCTGCTCTGCAGCCAAGTGAAAGAGATTAGTCCCTAAACCTGTGAAATCGACCAGAGCTGTGTGATTACCAGGGCTTGA GAGAGGACTCGAAAAGAAAAGGAGAAATAAATCAAACAGCCTGTCAGTTCCTTTGGCCACGTCAGAAGATGTCATCTCAAACTAAGTTCA AGAAAGACAAAGAGATCATTGCTGAATATGAAGCCCAAATAAAAGAGATCCGCACGCAGCTGGTGGAGCAGTTCAAATGTCTGGAGCAGC AATCAGAGTCGCGACTGCAGCTGCTTCAAGACCTCCAGGAGTTTTTCCGCCGGAAAGCTGAGATTGAGCTCGAGTACTCCCGCAGCCTGG AGAAGCTGGCTGAGCGCTTCTCCTCCAAAATCCGCAGCTCCCGGGAGCACCAGTTCAAGAAGGACCAGTACCTCCTCTCGCCTGTGAACT GTTGGTATCTGGTTCTGCATCAGACCCGGCGGGAGAGCCGAGACCATGCCACCCTCAATGACATCTTCATGAACAATGTCATCGTCCGCC TCTCCCAGATCAGTGAGGATGTCATCAGACTCTTCAAAAAGAGCAAGGAGATTGGCCTGCAGATGCACGAGGAGCTCCTGAAGGTGACCA ATGAGCTCTACACAGTCATGAAAACCTACCACATGTACCATGCAGAGAGCATCAGTGCGGAAAGCAAGCTGAAGGAGGCTGAGAAGCAGG AGGAGAAGCAGTTCAATAAGTCAGGAGACCTCAGCATGAACCTGCTCCGGCACGAGGACCGGCCCCAGCGCCGCAGCTCTGTGAAGAAGA TTGAGAAGATGAAGGAGAAGAGGCAGGCCAAGTACTCTGAGAACAAGCTGAAATGCACAAAGGCCCGGAATGACTACTTGCTCAATCTGG CAGCCACCAACGCAGCTATAAGCAAATACTACATCCATGATGTCTCTGATCTGATCGATTGCTGTGATTTGGGCTTCCATGCCAGCCTGG CCCGCACCTTCCGGACCTATCTCTCAGCTGAATACAACCTGGAGACCTCTCGCCACGAAGGGCTGGATGTCATTGAGAATGCAGTGGACA ACCTGGATTCCCGAAGTGACAAGCACACAGTCATGGACATGTGCAATCAAGTCTTCTGCCCTCCACTCAAGTTCGAGTTCCAGCCCCACA TGGGGGATGAGGTCTGCCAGGTCAGCGCTCAGCAGCCCGTCCAGACAGAACTGCTCATGCGTTATCACCAGCTGCAGTCCAGACTGGCCA CCCTCAAGATAGAGAATGAGGAGGTTAGGAAAACCCTGGATGCCACCATGCAGACATTACAGGACATGCTGACTGTGGAGGACTTTGATG TCTCCGATGCCTTCCAACACAGTCGATCGACAGAGTCCGTCAAGTCGGCTGCCTCTGAGACCTACATGAGCAAGATCAACATTGCCAAGA GGAGAGCCAACCAGCAGGAAACAGAAATGTTTTATTTTACAAAATTTAAAGAGTATGTGAATGGCAGTAACCTCATCACCAAGCTGCAGG CCAAGCACGATTTACTCAAGCAGACCCTGGGCGAAGGGGAAAGAGCAGAATGCGGCACCACCAGGCCCCCCTGTCTTCCCCCTAAACCAC AGAAAATGAGGAGACCTAGGCCTCTCTCAGTGTATAGCCATAAACTCTTTAACGGCAGTATGGAAGCATTCATTAAGAGGCCTCGTGGAC AGAGAGATTCAAGCTATTATTGGGAAATAGAAGCCAGTGAAGTGATGCTGTCCACTCGGATTGGGTCAGGCTCTTTTGGAACTGTTTATA AGGGTAAATGGCACGGAGATGTTGCAGTAAAGATCCTAAAGGTTGTCGACCCAACCCCAGAGCAATTCCAGGCCTTCAGGAATGAGGTGG CTGTTCTGCGCAAAACACGGCATGTGAACATTCTGCTTTTCATGGGGTACATGACAAAGGACAACCTGGCAATTGTGACCCAGTGGTGCG AGGGCAGCAGCCTCTACAAACACCTGCATGTCCAGGAGACCAAGTTTCAGATGTTCCAGCTAATTGACATTGCCCGGCAGACGGCTCAGG GAATGGACTATTTGCATGCAAAGAACATCATCCATAGAGACATGAAATCCAACAATATATTTCTCCATGAAGGCTTAACAGTGAAAATTG GAGATTTTGGTTTGGCAACAGTAAAGTCACGCTGGAGTGGTTCTCAGCAGGTTGAACAACCTACTGGCTCTGTCCTCTGGATGGCCCCAG AGGTGATCCGAATGCAGGATAACAACCCATTCAGTTTCCAGTCGGATGTCTACTCCTATGGCATCGTATTGTATGAACTGATGACGGGGG AGCTTCCTTATTCTCACATCAACAACCGAGATCAGATCATCTTCATGGTGGGCCGAGGATATGCCTCCCCAGATCTTAGTAAGCTATATA AGAACTGCCCCAAAGCAATGAAGAGGCTGGTAGCTGACTGTGTGAAGAAAGTAAAGGAAGAGAGGCCTCTTTTTCCCCAGATCCTGTCTT CCATTGAGCTGCTCCAACACTCTCTACCGAAGATCAACCGGAGCGCTTCCGAGCCATCCTTGCATCGGGCAGCCCACACTGAGGATATCA ATGCTTGCACGCTGACCACGTCCCCGAGGCTGCCTGTCTTCTAGTTGACTTTGCACCTGTCTTCAGGCTGCCAGGGGAGGAGGAGAAGCC AGCAGGCACCACTTTTCTGCTCCCTTTCTCCAGAGGCAGAACACATGTTTTCAGAGAAGCTGCTGCTAAGGACCTTCTAGACTGCTCACA >86395_86395_4_SRGAP3-RAF1_SRGAP3_chr3_9074334_ENST00000383836_RAF1_chr3_12641309_ENST00000542177_length(amino acids)=861AA_BP=543 MCDYQGLREDSKRKGEINQTACQFLWPRQKMSSQTKFKKDKEIIAEYEAQIKEIRTQLVEQFKCLEQQSESRLQLLQDLQEFFRRKAEIE LEYSRSLEKLAERFSSKIRSSREHQFKKDQYLLSPVNCWYLVLHQTRRESRDHATLNDIFMNNVIVRLSQISEDVIRLFKKSKEIGLQMH EELLKVTNELYTVMKTYHMYHAESISAESKLKEAEKQEEKQFNKSGDLSMNLLRHEDRPQRRSSVKKIEKMKEKRQAKYSENKLKCTKAR NDYLLNLAATNAAISKYYIHDVSDLIDCCDLGFHASLARTFRTYLSAEYNLETSRHEGLDVIENAVDNLDSRSDKHTVMDMCNQVFCPPL KFEFQPHMGDEVCQVSAQQPVQTELLMRYHQLQSRLATLKIENEEVRKTLDATMQTLQDMLTVEDFDVSDAFQHSRSTESVKSAASETYM SKINIAKRRANQQETEMFYFTKFKEYVNGSNLITKLQAKHDLLKQTLGEGERAECGTTRPPCLPPKPQKMRRPRPLSVYSHKLFNGSMEA FIKRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNL AIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTG SVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERP -------------------------------------------------------------- |
Top |
Fusion Gene PPI Analysis for SRGAP3-RAF1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | RAF1 | chr3:9074334 | chr3:12641309 | ENST00000251849 | 8 | 17 | 331_349 | 330.0 | 649.0 | PEBP1/RKIP |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | RAF1 | chr3:9074334 | chr3:12641309 | ENST00000442415 | 9 | 18 | 331_349 | 350.0 | 669.0 | PEBP1/RKIP |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs for SRGAP3-RAF1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
Related Diseases for SRGAP3-RAF1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies