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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SRP68-URM1 (FusionGDB2 ID:86462)

Fusion Gene Summary for SRP68-URM1

check button Fusion gene summary
Fusion gene informationFusion gene name: SRP68-URM1
Fusion gene ID: 86462
HgeneTgene
Gene symbol

SRP68

URM1

Gene ID

6730

81605

Gene namesignal recognition particle 68ubiquitin related modifier 1
Synonyms-C9orf74
Cytomap

17q25.1

9q34.11

Type of geneprotein-codingprotein-coding
Descriptionsignal recognition particle subunit SRP68signal recognition particle 68 kDa proteinsignal recognition particle 68kDsignal recognition particle 68kDaubiquitin-related modifier 1ubiquitin-related modifier 1 homolog
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000307877, ENST00000355113, 
ENST00000539137, ENST00000602720, 
ENST00000542536, 		ENST00000483206, 
ENST00000372847, ENST00000372850, 
ENST00000372853, ENST00000452446, 
Fusion gene scores* DoF score12 X 15 X 7=12606 X 5 X 5=150
# samples 178
** MAII scorelog2(17/1260*10)=-2.88981708224958
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/150*10)=-0.906890595608519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SRP68 [Title/Abstract] AND URM1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSRP68(74039910)-URM1(131150095), # samples:2
Anticipated loss of major functional domain due to fusion event.SRP68-URM1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
SRP68-URM1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SRP68-URM1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSRP68

GO:0042493

response to drug

18089836


check buttonFusion gene breakpoints across SRP68 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across URM1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0219-01ASRP68chr17

74039910

-URM1chr9

131150095

+
ChimerDB4GBMTCGA-06-0219SRP68chr17

74039909

-URM1chr9

131150094

+


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Fusion Gene ORF analysis for SRP68-URM1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000307877ENST00000483206SRP68chr17

74039910

-URM1chr9

131150095

+
5CDS-3UTRENST00000307877ENST00000483206SRP68chr17

74039909

-URM1chr9

131150094

+
5CDS-3UTRENST00000355113ENST00000483206SRP68chr17

74039910

-URM1chr9

131150095

+
5CDS-3UTRENST00000355113ENST00000483206SRP68chr17

74039909

-URM1chr9

131150094

+
5CDS-3UTRENST00000539137ENST00000483206SRP68chr17

74039910

-URM1chr9

131150095

+
5CDS-3UTRENST00000539137ENST00000483206SRP68chr17

74039909

-URM1chr9

131150094

+
5CDS-3UTRENST00000602720ENST00000483206SRP68chr17

74039910

-URM1chr9

131150095

+
5CDS-3UTRENST00000602720ENST00000483206SRP68chr17

74039909

-URM1chr9

131150094

+
5UTR-3CDSENST00000542536ENST00000372847SRP68chr17

74039910

-URM1chr9

131150095

+
5UTR-3CDSENST00000542536ENST00000372847SRP68chr17

74039909

-URM1chr9

131150094

+
5UTR-3CDSENST00000542536ENST00000372850SRP68chr17

74039910

-URM1chr9

131150095

+
5UTR-3CDSENST00000542536ENST00000372850SRP68chr17

74039909

-URM1chr9

131150094

+
5UTR-3CDSENST00000542536ENST00000372853SRP68chr17

74039910

-URM1chr9

131150095

+
5UTR-3CDSENST00000542536ENST00000372853SRP68chr17

74039909

-URM1chr9

131150094

+
5UTR-3CDSENST00000542536ENST00000452446SRP68chr17

74039910

-URM1chr9

131150095

+
5UTR-3CDSENST00000542536ENST00000452446SRP68chr17

74039909

-URM1chr9

131150094

+
5UTR-3UTRENST00000542536ENST00000483206SRP68chr17

74039910

-URM1chr9

131150095

+
5UTR-3UTRENST00000542536ENST00000483206SRP68chr17

74039909

-URM1chr9

131150094

+
Frame-shiftENST00000307877ENST00000372847SRP68chr17

74039910

-URM1chr9

131150095

+
Frame-shiftENST00000307877ENST00000372847SRP68chr17

74039909

-URM1chr9

131150094

+
Frame-shiftENST00000307877ENST00000372850SRP68chr17

74039910

-URM1chr9

131150095

+
Frame-shiftENST00000307877ENST00000372850SRP68chr17

74039909

-URM1chr9

131150094

+
Frame-shiftENST00000307877ENST00000372853SRP68chr17

74039910

-URM1chr9

131150095

+
Frame-shiftENST00000307877ENST00000372853SRP68chr17

74039909

-URM1chr9

131150094

+
Frame-shiftENST00000307877ENST00000452446SRP68chr17

74039910

-URM1chr9

131150095

+
Frame-shiftENST00000307877ENST00000452446SRP68chr17

74039909

-URM1chr9

131150094

+
Frame-shiftENST00000355113ENST00000372847SRP68chr17

74039910

-URM1chr9

131150095

+
Frame-shiftENST00000355113ENST00000372847SRP68chr17

74039909

-URM1chr9

131150094

+
Frame-shiftENST00000355113ENST00000372853SRP68chr17

74039910

-URM1chr9

131150095

+
Frame-shiftENST00000355113ENST00000372853SRP68chr17

74039909

-URM1chr9

131150094

+
Frame-shiftENST00000355113ENST00000452446SRP68chr17

74039910

-URM1chr9

131150095

+
Frame-shiftENST00000355113ENST00000452446SRP68chr17

74039909

-URM1chr9

131150094

+
Frame-shiftENST00000539137ENST00000372847SRP68chr17

74039910

-URM1chr9

131150095

+
Frame-shiftENST00000539137ENST00000372847SRP68chr17

74039909

-URM1chr9

131150094

+
Frame-shiftENST00000539137ENST00000372850SRP68chr17

74039910

-URM1chr9

131150095

+
Frame-shiftENST00000539137ENST00000372850SRP68chr17

74039909

-URM1chr9

131150094

+
Frame-shiftENST00000539137ENST00000372853SRP68chr17

74039910

-URM1chr9

131150095

+
Frame-shiftENST00000539137ENST00000372853SRP68chr17

74039909

-URM1chr9

131150094

+
Frame-shiftENST00000539137ENST00000452446SRP68chr17

74039910

-URM1chr9

131150095

+
Frame-shiftENST00000539137ENST00000452446SRP68chr17

74039909

-URM1chr9

131150094

+
Frame-shiftENST00000602720ENST00000372847SRP68chr17

74039910

-URM1chr9

131150095

+
Frame-shiftENST00000602720ENST00000372847SRP68chr17

74039909

-URM1chr9

131150094

+
Frame-shiftENST00000602720ENST00000372850SRP68chr17

74039910

-URM1chr9

131150095

+
Frame-shiftENST00000602720ENST00000372850SRP68chr17

74039909

-URM1chr9

131150094

+
Frame-shiftENST00000602720ENST00000372853SRP68chr17

74039910

-URM1chr9

131150095

+
Frame-shiftENST00000602720ENST00000372853SRP68chr17

74039909

-URM1chr9

131150094

+
Frame-shiftENST00000602720ENST00000452446SRP68chr17

74039910

-URM1chr9

131150095

+
Frame-shiftENST00000602720ENST00000452446SRP68chr17

74039909

-URM1chr9

131150094

+
In-frameENST00000355113ENST00000372850SRP68chr17

74039910

-URM1chr9

131150095

+
In-frameENST00000355113ENST00000372850SRP68chr17

74039909

-URM1chr9

131150094

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355113SRP68chr1774039909-ENST00000372850URM1chr9131150094+43451426101470486
ENST00000355113SRP68chr1774039910-ENST00000372850URM1chr9131150095+43451426101470486

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355113ENST00000372850SRP68chr1774039909-URM1chr9131150094+0.0035384970.9964616
ENST00000355113ENST00000372850SRP68chr1774039910-URM1chr9131150095+0.0035384970.9964616

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Fusion Genomic Features for SRP68-URM1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SRP68chr1774039909-URM1chr9131150094+5.82E-070.9999994
SRP68chr1774039909-URM1chr9131150094+5.82E-070.9999994
SRP68chr1774039909-URM1chr9131150094+5.82E-070.9999994
SRP68chr1774039909-URM1chr9131150094+5.82E-070.9999994

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SRP68-URM1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:74039910/chr9:131150095)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSRP68chr17:74039909chr9:131150094ENST00000307877-13169_24508628.0Compositional biasNote=Poly-Gly
HgeneSRP68chr17:74039909chr9:131150094ENST00000539137-12159_24470590.0Compositional biasNote=Poly-Gly
HgeneSRP68chr17:74039909chr9:131150094ENST00000602720-699_24169289.0Compositional biasNote=Poly-Gly
HgeneSRP68chr17:74039910chr9:131150095ENST00000307877-13169_24508628.0Compositional biasNote=Poly-Gly
HgeneSRP68chr17:74039910chr9:131150095ENST00000539137-12159_24470590.0Compositional biasNote=Poly-Gly
HgeneSRP68chr17:74039910chr9:131150095ENST00000602720-699_24169289.0Compositional biasNote=Poly-Gly

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SRP68-URM1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>86462_86462_1_SRP68-URM1_SRP68_chr17_74039909_ENST00000355113_URM1_chr9_131150094_ENST00000372850_length(transcript)=4345nt_BP=1426nt
GGCAAGATGGCTGCTGAGAAGCAGGTCCCAGGCGGCGGCGGCGGCGGCGGCAGTGGCGGCGGCGGTGGCAGTGGCGGCGGCGGTAGCGGC
GGTGGACGTGGTGCCGGAGGGGAAGAAAATAAAGAAAACGAACGCCCTTCGGCCGGATCGAAGGGGCTACTGTTCCCGTAGACAAAGACG
TCTTCGAAAAACACTCAACTTCAAGATGGGTAACAGACACAAATTCACAGGGAAGAAAGTGACTGAAGAGCTTCTGACCGATAATAGATA
CTTGCTTCTGGTTCTGATGGATGCTGAAAGAGCCTGGAGCTACGCCATGCAGCTGAAACAGGAAGCCAACACTGAACCCCGAAAACGGTT
TCACTTGTTATCTCGCCTACGCAAAGCCGTGAAGCATGCAGAGGAATTGGAACGCTTGTGTGAGAGCAATCGCGTGGATGCCAAGACCAA
ATTAGAGGCTCAGGCTTACACAGCTTACCTCTCAGGAATGCTACGTTTTGAACATCAAGAATGGAAAGCTGCCATTGAGGCTTTTAACAA
ATGCAAAACTATCTATGAGAAGCTAGCCAGTGCTTTCACAGAGGAGCAGGCTGTGCTGTATAACCAACGTGTGGAAGAGATTTCACCCAA
CATCCGCTATTGTGCATATAATATTGGGGACCAGTCAGCCATCAATGAACTCATGCAGATGAGATTGAGGTCTGGGGGCACTGAGGGTCT
CTTGGCTGAAAAATTGGAGGCTTTGATCACTCAGACTCGAGCCAAACAGGCAGCTACCATGAGTGAAGTGGAGTGGAGAGGGAGAACGGT
TCCAGTGAAGATTGACAAAGTGCGCATTTTCTTATTAGGACTGGCTGATAACGAAGCAGCTATTGTCCAGGCTGAAAGCGAAGAAACTAA
GGAGCGCCTGTTTGAATCAATGCTCAGCGAGTGTCGGGACGCCATCCAGGTGGTTCGGGAGGAGCTCAAGCCAGATCAGAAACAGAGAGA
TTATATCCTTGAAGGAGAGCCAGGGAAGGTGTCTAATCTTCAATACTTGCATAGCTACCTGACTTACATCAAGCTATCAACGGCAATCAA
GCGTAATGAGAACATGGCCAAAGGTCTGCAGAGGGCTCTGCTGCAGCAGCAGCCAGAGGATGACAGCAAGCGCTCACCCCGGCCCCAGGA
CCTGATCCGACTCTATGACATCATCTTACAGAATCTGGTGGAATTGCTCCAGCTTCCTGGTTTAGAGGAAGACAAAGCCTTCCAGAAAGA
GATAGGCCTCAAGACTCTGGTGTTCAAAGCTTACAGGTGTTTTTTCATTGCTCAGTCCTATGTGCTGGTGAAGAAGTGGAGCGAAGCCCT
TGTCCTGTATGACAGAGTCCTGAAATATGCAAATGAAGTAAATTCTGATGCTGGCGCCTTCAAGAACAGCCTAAAGGGGACATCCGGAAC
CTGCTCATCTGGATCAAGAAGAATTTGCTAAAAGAGCGGCCAGAGTTGTTCATCCAGGGAGACAGCGTGTGAGTCCCACTCCTCCCTTCC
CTGAAGCAGGTGGAGGGAGGGACGGATATTTGAGCCCCCACCCTCGGGTTCAGTCCTGGCCTTCTCTGAATCCGGTTCTCCCCTTCCTCC
TCCCTAACTCTTCCAGCTCTGAGATCTGTTTTCAGTTTTCTTGTTACTAAACCGAACTCTTGAGGATTTTTTAAATCCCAGATGAAAGGA
GCCTGGTGAATTTCTCAGAAAACTTGGATTCTGCCCTCTGGTTGCCACAGACTTGCTGTGGGACCTTAGGCGACTTACTTCGCTTCTCTG
GGCCTCAGTTACTCTCTACACAGAAAGTGCTGAGGAAAAAACGTAGCTAGTACAACTGAAGAGCTAAATATTCTGTTTTATTTCATTGTA
ATTTAAATAGCCACATGCAGCTAGTAGATTACCATACAGTGCAGCACGGGTCTAGAATTCCAAGGAGTCATTGACTCTGTGCGTGCACAC
ACCCATGCACATGCACACACACTCACTGGGGACACCCCATAGAAGCCCAGTGCAGTCTCCTTGGAAAGGACCAGGTTCCAGTTGCCACGA
AGTTACTTCTAAAACAAGGCCAGTCCCCCACGTGAAAGGTGGCCGGTGCAGTTGTGAGGCTCGCTTATTTGCCTCGAAGCATAGGTCACT
GTCAGGTCCTAAGGGATCAGGCCTAGGGGATCAGCCCTCCTTCAGGTCATGGTCCAGTGGTCCTGGAGGCCACCTCTAAGGCCAGCAGTG
CTCCTTGGGCCATTACCAGTGGGAGCCAGGCTAAGCTGCCTGACCAAATGTTGACCTACCCTGCCTTATGCCAGGCAGGACTGCACGTGA
GCATTGCCATGTGGCATGGCAACTGATTCGGAAGAGGCAAAACAGCCTTCTCTCCAGGATGGGCATGCAGAGGCCTAAAAAAAAGCCGAA
GTTCTTTTCCAGGGCTAACGAGAATAAGATTAGACCCCTGGAAAAGTCCTACTAATGGTTACCATGACAGTGTGGCAAGCACTCCACACA
TATCAGCTCATTTCGTTTTCGTATAGGCCTTGTGGGTTAGACAGTATCACTTATCCCATTTTCAGATGAGGAACCTGATACTCAGAAACA
AAATGACCTGCCCATGGTCTGGGTGGTGGTGCTGGCTGGCATTTGCACCCATTTTCCATCTGGCTACAAAGACCATGCATGACTGACCTG
GTTTCCTTCACACTCAGACCAGCCTCCCCTTCCTGGGATATCTTTAGCCAGACCCCAGGAGGAAGGCTCCTCAGCACACTCTCCTGCAGC
CCAAAGCTCTCAGCCTCTCTTCCTCTGTGCTACTGCCTCCTGCCTCTCACTCCTTGCTACTCACCACCATCTTTCCCACAGGCGGCCAGG
AATTCTGGTGCTGATTAACGATGCCGACTGGGAGCTACTGGTCAGTACCTTGGGGGACATCCCTCCCCCAGCCCCTGCCCTTGCTGCTTC
AGTGGGAAAGCGTTGGGCCTCTCCTCAGGCACATATAGAGTGGCTGGGTAATCCTCCGCCCCACTCCAGCCCCACACTGAGGCTGCTGGA
GTCTCCCACTCCAGGTGAGGAAGGGATGGGTAGCTGGGGACATGGGAGTACTCCTCCATCCTGAAGATTTGCAGGTTGAGGTATAGGATA
CCCATTTTTCTGGTAGAGTCTGTCTCTTCCAGAGCAGCCAGTCCTCAGCCCCTGTTCTCCCAACTCCTGGGGTGGACCTGGGAAGGTGGC
CCTGAGGGTCTCCCGCTCCCCTCTCTCCCGCACCAGGGTGAGCTGGACTACCAGCTTCAGGACCAGGACAGCGTCCTCTTCATCTCCACT
CTGCACGGCGGCTGAGGGCCCTTCTCTGGGCCTGGGCACCCTTAGAGGGGAGAACGAAGCAATCAGACATCCCCTTGGGCCCTGCTTCCA
GGTCTCCCTGTCCCCCTTGCCTGCCTTCTTCCCTGCTCTGTCCCCTAAGCTCCCTCCAGGCAGGGAAAAGAGGCCAGGTGCTAAAAATGA
GCCTTTCTCAAGCACGTGAGCAGCGGAAGGCAGACAGGCGCCAGAGCCCAGCACTCCCTTTTCCAGCAGCTGTGGTGGGGGAGGGTTCCC
CTCCAGTTTGTCAAGAGTTGAAGGAGGCTCTGTGGCCAGGTGACCTGGCTGCCTTCCACTCCTTGTACCTCAGTCTAAACATGGAGTGGC
CGCTGACAAGGCGCTCCAGCCCCAGAGCCAGCGTCTTCATGGGGAAGATGAATGGACCTGAGTAGCTGAAGGAAGGCCCCTCCCTACCCA
AAGACTGGAGGCTTCTCAGCCTCAATTTCCCTGTCTGTACAGCTGAGGGCTCTGCCTGTCCCCCACTGCTATCAGTATGGAACCCCAGCT
GGGGTCCCCTATTGAGTGCCGACTCCCCCCACCGCCAGCAGCTGCTCCTCCAGCCACACCCCTCCTGCTCCCCCCACCCCTAGCCCTTGA
CCCTGGCTGGCCTGCCCCGCTCCACAGGCCACCAGATGGGCTCCTGAGACCCTCCCCAGGCTGCTTACAGCTCATTCTGCTGGGGGTAGA
GATGAGGGGAGGGAGTAAGTTAAACCTTGGACTAGCAAGTAGAAGCCTGGGGGGATGCGTGTGCCTCAGTTTCCTCCTCCACAACTGAAT
ATAGTGGCTGAAAACTGGGGAGATACTTGATGGCGCGAATGTCCGTTTTCTCTCCCTTCCCACCTCCTGCAGGAAGCAGGACGGGGCAGG
CAGCACCTGGTAGGCACAGTGCTTTGCCCCTCCTCCCCTTCCCTTCTGGAAGTCTTGGGGCCTCAGTGCTTGCAACAGCCGGCCTTGGGC

>86462_86462_1_SRP68-URM1_SRP68_chr17_74039909_ENST00000355113_URM1_chr9_131150094_ENST00000372850_length(amino acids)=486AA_BP=7
MLRSRSQAAAAAAAVAAAVAVAAAVAAVDVVPEGKKIKKTNALRPDRRGYCSRRQRRLRKTLNFKMGNRHKFTGKKVTEELLTDNRYLLL
VLMDAERAWSYAMQLKQEANTEPRKRFHLLSRLRKAVKHAEELERLCESNRVDAKTKLEAQAYTAYLSGMLRFEHQEWKAAIEAFNKCKT
IYEKLASAFTEEQAVLYNQRVEEISPNIRYCAYNIGDQSAINELMQMRLRSGGTEGLLAEKLEALITQTRAKQAATMSEVEWRGRTVPVK
IDKVRIFLLGLADNEAAIVQAESEETKERLFESMLSECRDAIQVVREELKPDQKQRDYILEGEPGKVSNLQYLHSYLTYIKLSTAIKRNE
NMAKGLQRALLQQQPEDDSKRSPRPQDLIRLYDIILQNLVELLQLPGLEEDKAFQKEIGLKTLVFKAYRCFFIAQSYVLVKKWSEALVLY

--------------------------------------------------------------
>86462_86462_2_SRP68-URM1_SRP68_chr17_74039910_ENST00000355113_URM1_chr9_131150095_ENST00000372850_length(transcript)=4345nt_BP=1426nt
GGCAAGATGGCTGCTGAGAAGCAGGTCCCAGGCGGCGGCGGCGGCGGCGGCAGTGGCGGCGGCGGTGGCAGTGGCGGCGGCGGTAGCGGC
GGTGGACGTGGTGCCGGAGGGGAAGAAAATAAAGAAAACGAACGCCCTTCGGCCGGATCGAAGGGGCTACTGTTCCCGTAGACAAAGACG
TCTTCGAAAAACACTCAACTTCAAGATGGGTAACAGACACAAATTCACAGGGAAGAAAGTGACTGAAGAGCTTCTGACCGATAATAGATA
CTTGCTTCTGGTTCTGATGGATGCTGAAAGAGCCTGGAGCTACGCCATGCAGCTGAAACAGGAAGCCAACACTGAACCCCGAAAACGGTT
TCACTTGTTATCTCGCCTACGCAAAGCCGTGAAGCATGCAGAGGAATTGGAACGCTTGTGTGAGAGCAATCGCGTGGATGCCAAGACCAA
ATTAGAGGCTCAGGCTTACACAGCTTACCTCTCAGGAATGCTACGTTTTGAACATCAAGAATGGAAAGCTGCCATTGAGGCTTTTAACAA
ATGCAAAACTATCTATGAGAAGCTAGCCAGTGCTTTCACAGAGGAGCAGGCTGTGCTGTATAACCAACGTGTGGAAGAGATTTCACCCAA
CATCCGCTATTGTGCATATAATATTGGGGACCAGTCAGCCATCAATGAACTCATGCAGATGAGATTGAGGTCTGGGGGCACTGAGGGTCT
CTTGGCTGAAAAATTGGAGGCTTTGATCACTCAGACTCGAGCCAAACAGGCAGCTACCATGAGTGAAGTGGAGTGGAGAGGGAGAACGGT
TCCAGTGAAGATTGACAAAGTGCGCATTTTCTTATTAGGACTGGCTGATAACGAAGCAGCTATTGTCCAGGCTGAAAGCGAAGAAACTAA
GGAGCGCCTGTTTGAATCAATGCTCAGCGAGTGTCGGGACGCCATCCAGGTGGTTCGGGAGGAGCTCAAGCCAGATCAGAAACAGAGAGA
TTATATCCTTGAAGGAGAGCCAGGGAAGGTGTCTAATCTTCAATACTTGCATAGCTACCTGACTTACATCAAGCTATCAACGGCAATCAA
GCGTAATGAGAACATGGCCAAAGGTCTGCAGAGGGCTCTGCTGCAGCAGCAGCCAGAGGATGACAGCAAGCGCTCACCCCGGCCCCAGGA
CCTGATCCGACTCTATGACATCATCTTACAGAATCTGGTGGAATTGCTCCAGCTTCCTGGTTTAGAGGAAGACAAAGCCTTCCAGAAAGA
GATAGGCCTCAAGACTCTGGTGTTCAAAGCTTACAGGTGTTTTTTCATTGCTCAGTCCTATGTGCTGGTGAAGAAGTGGAGCGAAGCCCT
TGTCCTGTATGACAGAGTCCTGAAATATGCAAATGAAGTAAATTCTGATGCTGGCGCCTTCAAGAACAGCCTAAAGGGGACATCCGGAAC
CTGCTCATCTGGATCAAGAAGAATTTGCTAAAAGAGCGGCCAGAGTTGTTCATCCAGGGAGACAGCGTGTGAGTCCCACTCCTCCCTTCC
CTGAAGCAGGTGGAGGGAGGGACGGATATTTGAGCCCCCACCCTCGGGTTCAGTCCTGGCCTTCTCTGAATCCGGTTCTCCCCTTCCTCC
TCCCTAACTCTTCCAGCTCTGAGATCTGTTTTCAGTTTTCTTGTTACTAAACCGAACTCTTGAGGATTTTTTAAATCCCAGATGAAAGGA
GCCTGGTGAATTTCTCAGAAAACTTGGATTCTGCCCTCTGGTTGCCACAGACTTGCTGTGGGACCTTAGGCGACTTACTTCGCTTCTCTG
GGCCTCAGTTACTCTCTACACAGAAAGTGCTGAGGAAAAAACGTAGCTAGTACAACTGAAGAGCTAAATATTCTGTTTTATTTCATTGTA
ATTTAAATAGCCACATGCAGCTAGTAGATTACCATACAGTGCAGCACGGGTCTAGAATTCCAAGGAGTCATTGACTCTGTGCGTGCACAC
ACCCATGCACATGCACACACACTCACTGGGGACACCCCATAGAAGCCCAGTGCAGTCTCCTTGGAAAGGACCAGGTTCCAGTTGCCACGA
AGTTACTTCTAAAACAAGGCCAGTCCCCCACGTGAAAGGTGGCCGGTGCAGTTGTGAGGCTCGCTTATTTGCCTCGAAGCATAGGTCACT
GTCAGGTCCTAAGGGATCAGGCCTAGGGGATCAGCCCTCCTTCAGGTCATGGTCCAGTGGTCCTGGAGGCCACCTCTAAGGCCAGCAGTG
CTCCTTGGGCCATTACCAGTGGGAGCCAGGCTAAGCTGCCTGACCAAATGTTGACCTACCCTGCCTTATGCCAGGCAGGACTGCACGTGA
GCATTGCCATGTGGCATGGCAACTGATTCGGAAGAGGCAAAACAGCCTTCTCTCCAGGATGGGCATGCAGAGGCCTAAAAAAAAGCCGAA
GTTCTTTTCCAGGGCTAACGAGAATAAGATTAGACCCCTGGAAAAGTCCTACTAATGGTTACCATGACAGTGTGGCAAGCACTCCACACA
TATCAGCTCATTTCGTTTTCGTATAGGCCTTGTGGGTTAGACAGTATCACTTATCCCATTTTCAGATGAGGAACCTGATACTCAGAAACA
AAATGACCTGCCCATGGTCTGGGTGGTGGTGCTGGCTGGCATTTGCACCCATTTTCCATCTGGCTACAAAGACCATGCATGACTGACCTG
GTTTCCTTCACACTCAGACCAGCCTCCCCTTCCTGGGATATCTTTAGCCAGACCCCAGGAGGAAGGCTCCTCAGCACACTCTCCTGCAGC
CCAAAGCTCTCAGCCTCTCTTCCTCTGTGCTACTGCCTCCTGCCTCTCACTCCTTGCTACTCACCACCATCTTTCCCACAGGCGGCCAGG
AATTCTGGTGCTGATTAACGATGCCGACTGGGAGCTACTGGTCAGTACCTTGGGGGACATCCCTCCCCCAGCCCCTGCCCTTGCTGCTTC
AGTGGGAAAGCGTTGGGCCTCTCCTCAGGCACATATAGAGTGGCTGGGTAATCCTCCGCCCCACTCCAGCCCCACACTGAGGCTGCTGGA
GTCTCCCACTCCAGGTGAGGAAGGGATGGGTAGCTGGGGACATGGGAGTACTCCTCCATCCTGAAGATTTGCAGGTTGAGGTATAGGATA
CCCATTTTTCTGGTAGAGTCTGTCTCTTCCAGAGCAGCCAGTCCTCAGCCCCTGTTCTCCCAACTCCTGGGGTGGACCTGGGAAGGTGGC
CCTGAGGGTCTCCCGCTCCCCTCTCTCCCGCACCAGGGTGAGCTGGACTACCAGCTTCAGGACCAGGACAGCGTCCTCTTCATCTCCACT
CTGCACGGCGGCTGAGGGCCCTTCTCTGGGCCTGGGCACCCTTAGAGGGGAGAACGAAGCAATCAGACATCCCCTTGGGCCCTGCTTCCA
GGTCTCCCTGTCCCCCTTGCCTGCCTTCTTCCCTGCTCTGTCCCCTAAGCTCCCTCCAGGCAGGGAAAAGAGGCCAGGTGCTAAAAATGA
GCCTTTCTCAAGCACGTGAGCAGCGGAAGGCAGACAGGCGCCAGAGCCCAGCACTCCCTTTTCCAGCAGCTGTGGTGGGGGAGGGTTCCC
CTCCAGTTTGTCAAGAGTTGAAGGAGGCTCTGTGGCCAGGTGACCTGGCTGCCTTCCACTCCTTGTACCTCAGTCTAAACATGGAGTGGC
CGCTGACAAGGCGCTCCAGCCCCAGAGCCAGCGTCTTCATGGGGAAGATGAATGGACCTGAGTAGCTGAAGGAAGGCCCCTCCCTACCCA
AAGACTGGAGGCTTCTCAGCCTCAATTTCCCTGTCTGTACAGCTGAGGGCTCTGCCTGTCCCCCACTGCTATCAGTATGGAACCCCAGCT
GGGGTCCCCTATTGAGTGCCGACTCCCCCCACCGCCAGCAGCTGCTCCTCCAGCCACACCCCTCCTGCTCCCCCCACCCCTAGCCCTTGA
CCCTGGCTGGCCTGCCCCGCTCCACAGGCCACCAGATGGGCTCCTGAGACCCTCCCCAGGCTGCTTACAGCTCATTCTGCTGGGGGTAGA
GATGAGGGGAGGGAGTAAGTTAAACCTTGGACTAGCAAGTAGAAGCCTGGGGGGATGCGTGTGCCTCAGTTTCCTCCTCCACAACTGAAT
ATAGTGGCTGAAAACTGGGGAGATACTTGATGGCGCGAATGTCCGTTTTCTCTCCCTTCCCACCTCCTGCAGGAAGCAGGACGGGGCAGG
CAGCACCTGGTAGGCACAGTGCTTTGCCCCTCCTCCCCTTCCCTTCTGGAAGTCTTGGGGCCTCAGTGCTTGCAACAGCCGGCCTTGGGC

>86462_86462_2_SRP68-URM1_SRP68_chr17_74039910_ENST00000355113_URM1_chr9_131150095_ENST00000372850_length(amino acids)=486AA_BP=7
MLRSRSQAAAAAAAVAAAVAVAAAVAAVDVVPEGKKIKKTNALRPDRRGYCSRRQRRLRKTLNFKMGNRHKFTGKKVTEELLTDNRYLLL
VLMDAERAWSYAMQLKQEANTEPRKRFHLLSRLRKAVKHAEELERLCESNRVDAKTKLEAQAYTAYLSGMLRFEHQEWKAAIEAFNKCKT
IYEKLASAFTEEQAVLYNQRVEEISPNIRYCAYNIGDQSAINELMQMRLRSGGTEGLLAEKLEALITQTRAKQAATMSEVEWRGRTVPVK
IDKVRIFLLGLADNEAAIVQAESEETKERLFESMLSECRDAIQVVREELKPDQKQRDYILEGEPGKVSNLQYLHSYLTYIKLSTAIKRNE
NMAKGLQRALLQQQPEDDSKRSPRPQDLIRLYDIILQNLVELLQLPGLEEDKAFQKEIGLKTLVFKAYRCFFIAQSYVLVKKWSEALVLY

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Fusion Gene PPI Analysis for SRP68-URM1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SRP68-URM1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SRP68-URM1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource