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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SRPK1-CCND3 (FusionGDB2 ID:86480)

Fusion Gene Summary for SRPK1-CCND3

check button Fusion gene summary
Fusion gene informationFusion gene name: SRPK1-CCND3
Fusion gene ID: 86480
HgeneTgene
Gene symbol

SRPK1

CCND3

Gene ID

6732

896

Gene nameSRSF protein kinase 1cyclin D3
SynonymsSFRSK1-
Cytomap

6p21.31

6p21.1

Type of geneprotein-codingprotein-coding
DescriptionSRSF protein kinase 1SFRS protein kinase 1SR-protein-specific kinase 1serine/arginine-rich splicing factor kinase 1serine/threonine-protein kinase SRPK1G1/S-specific cyclin-D3D3-type cyclin
Modification date2020032720200313
UniProtAcc.

P30281

Ensembl transtripts involved in fusion geneENST00000373825, ENST00000373822, 
ENST00000423325, ENST00000373821, 
ENST00000372987, ENST00000372988, 
ENST00000372991, ENST00000414200, 
ENST00000415497, ENST00000510503, 
ENST00000511642, ENST00000511686, 
Fusion gene scores* DoF score16 X 12 X 10=19209 X 3 X 7=189
# samples 2111
** MAII scorelog2(21/1920*10)=-3.1926450779424
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/189*10)=-0.780882710696413
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SRPK1 [Title/Abstract] AND CCND3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSRPK1(35888245)-CCND3(41908323), # samples:3
Anticipated loss of major functional domain due to fusion event.SRPK1-CCND3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SRPK1-CCND3 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
SRPK1-CCND3 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSRPK1

GO:0006468

protein phosphorylation

9237760|11509566

HgeneSRPK1

GO:0007059

chromosome segregation

15034300

HgeneSRPK1

GO:0035556

intracellular signal transduction

11509566

HgeneSRPK1

GO:0045070

positive regulation of viral genome replication

20498328

HgeneSRPK1

GO:0045071

negative regulation of viral genome replication

12417631

HgeneSRPK1

GO:0050684

regulation of mRNA processing

8208298

TgeneCCND3

GO:0001934

positive regulation of protein phosphorylation

8114739

TgeneCCND3

GO:0045737

positive regulation of cyclin-dependent protein serine/threonine kinase activity

8114739


check buttonFusion gene breakpoints across SRPK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CCND3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A925-01ASRPK1chr6

35888245

-CCND3chr6

41905132

-
ChimerDB4STADTCGA-VQ-A925-01ASRPK1chr6

35888245

-CCND3chr6

41908323

-
ChimerDB4STADTCGA-VQ-A925SRPK1chr6

35888244

-CCND3chr6

41905132

-
ChimerDB4STADTCGA-VQ-A925SRPK1chr6

35888244

-CCND3chr6

41908323

-


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Fusion Gene ORF analysis for SRPK1-CCND3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000373825ENST00000372987SRPK1chr6

35888245

-CCND3chr6

41905132

-
5CDS-5UTRENST00000373825ENST00000372987SRPK1chr6

35888244

-CCND3chr6

41905132

-
5CDS-5UTRENST00000373825ENST00000372988SRPK1chr6

35888245

-CCND3chr6

41905132

-
5CDS-5UTRENST00000373825ENST00000372988SRPK1chr6

35888245

-CCND3chr6

41908323

-
5CDS-5UTRENST00000373825ENST00000372988SRPK1chr6

35888244

-CCND3chr6

41905132

-
5CDS-5UTRENST00000373825ENST00000372988SRPK1chr6

35888244

-CCND3chr6

41908323

-
5CDS-5UTRENST00000373825ENST00000372991SRPK1chr6

35888245

-CCND3chr6

41905132

-
5CDS-5UTRENST00000373825ENST00000372991SRPK1chr6

35888244

-CCND3chr6

41905132

-
5CDS-5UTRENST00000373825ENST00000414200SRPK1chr6

35888245

-CCND3chr6

41905132

-
5CDS-5UTRENST00000373825ENST00000414200SRPK1chr6

35888244

-CCND3chr6

41905132

-
5CDS-5UTRENST00000373825ENST00000415497SRPK1chr6

35888245

-CCND3chr6

41905132

-
5CDS-5UTRENST00000373825ENST00000415497SRPK1chr6

35888244

-CCND3chr6

41905132

-
5CDS-5UTRENST00000373825ENST00000510503SRPK1chr6

35888245

-CCND3chr6

41905132

-
5CDS-5UTRENST00000373825ENST00000510503SRPK1chr6

35888245

-CCND3chr6

41908323

-
5CDS-5UTRENST00000373825ENST00000510503SRPK1chr6

35888244

-CCND3chr6

41905132

-
5CDS-5UTRENST00000373825ENST00000510503SRPK1chr6

35888244

-CCND3chr6

41908323

-
5CDS-5UTRENST00000373825ENST00000511642SRPK1chr6

35888245

-CCND3chr6

41908323

-
5CDS-5UTRENST00000373825ENST00000511642SRPK1chr6

35888244

-CCND3chr6

41908323

-
5CDS-5UTRENST00000373825ENST00000511686SRPK1chr6

35888245

-CCND3chr6

41905132

-
5CDS-5UTRENST00000373825ENST00000511686SRPK1chr6

35888244

-CCND3chr6

41905132

-
5CDS-intronENST00000373825ENST00000372987SRPK1chr6

35888245

-CCND3chr6

41908323

-
5CDS-intronENST00000373825ENST00000372987SRPK1chr6

35888244

-CCND3chr6

41908323

-
5CDS-intronENST00000373825ENST00000372991SRPK1chr6

35888245

-CCND3chr6

41908323

-
5CDS-intronENST00000373825ENST00000372991SRPK1chr6

35888244

-CCND3chr6

41908323

-
5CDS-intronENST00000373825ENST00000414200SRPK1chr6

35888245

-CCND3chr6

41908323

-
5CDS-intronENST00000373825ENST00000414200SRPK1chr6

35888244

-CCND3chr6

41908323

-
5CDS-intronENST00000373825ENST00000415497SRPK1chr6

35888245

-CCND3chr6

41908323

-
5CDS-intronENST00000373825ENST00000415497SRPK1chr6

35888244

-CCND3chr6

41908323

-
5CDS-intronENST00000373825ENST00000511686SRPK1chr6

35888245

-CCND3chr6

41908323

-
5CDS-intronENST00000373825ENST00000511686SRPK1chr6

35888244

-CCND3chr6

41908323

-
5UTR-3CDSENST00000373822ENST00000511642SRPK1chr6

35888245

-CCND3chr6

41905132

-
5UTR-3CDSENST00000373822ENST00000511642SRPK1chr6

35888244

-CCND3chr6

41905132

-
5UTR-3CDSENST00000423325ENST00000511642SRPK1chr6

35888245

-CCND3chr6

41905132

-
5UTR-3CDSENST00000423325ENST00000511642SRPK1chr6

35888244

-CCND3chr6

41905132

-
5UTR-5UTRENST00000373822ENST00000372987SRPK1chr6

35888245

-CCND3chr6

41905132

-
5UTR-5UTRENST00000373822ENST00000372987SRPK1chr6

35888244

-CCND3chr6

41905132

-
5UTR-5UTRENST00000373822ENST00000372988SRPK1chr6

35888245

-CCND3chr6

41905132

-
5UTR-5UTRENST00000373822ENST00000372988SRPK1chr6

35888245

-CCND3chr6

41908323

-
5UTR-5UTRENST00000373822ENST00000372988SRPK1chr6

35888244

-CCND3chr6

41905132

-
5UTR-5UTRENST00000373822ENST00000372988SRPK1chr6

35888244

-CCND3chr6

41908323

-
5UTR-5UTRENST00000373822ENST00000372991SRPK1chr6

35888245

-CCND3chr6

41905132

-
5UTR-5UTRENST00000373822ENST00000372991SRPK1chr6

35888244

-CCND3chr6

41905132

-
5UTR-5UTRENST00000373822ENST00000414200SRPK1chr6

35888245

-CCND3chr6

41905132

-
5UTR-5UTRENST00000373822ENST00000414200SRPK1chr6

35888244

-CCND3chr6

41905132

-
5UTR-5UTRENST00000373822ENST00000415497SRPK1chr6

35888245

-CCND3chr6

41905132

-
5UTR-5UTRENST00000373822ENST00000415497SRPK1chr6

35888244

-CCND3chr6

41905132

-
5UTR-5UTRENST00000373822ENST00000510503SRPK1chr6

35888245

-CCND3chr6

41905132

-
5UTR-5UTRENST00000373822ENST00000510503SRPK1chr6

35888245

-CCND3chr6

41908323

-
5UTR-5UTRENST00000373822ENST00000510503SRPK1chr6

35888244

-CCND3chr6

41905132

-
5UTR-5UTRENST00000373822ENST00000510503SRPK1chr6

35888244

-CCND3chr6

41908323

-
5UTR-5UTRENST00000373822ENST00000511642SRPK1chr6

35888245

-CCND3chr6

41908323

-
5UTR-5UTRENST00000373822ENST00000511642SRPK1chr6

35888244

-CCND3chr6

41908323

-
5UTR-5UTRENST00000373822ENST00000511686SRPK1chr6

35888245

-CCND3chr6

41905132

-
5UTR-5UTRENST00000373822ENST00000511686SRPK1chr6

35888244

-CCND3chr6

41905132

-
5UTR-5UTRENST00000423325ENST00000372987SRPK1chr6

35888245

-CCND3chr6

41905132

-
5UTR-5UTRENST00000423325ENST00000372987SRPK1chr6

35888244

-CCND3chr6

41905132

-
5UTR-5UTRENST00000423325ENST00000372988SRPK1chr6

35888245

-CCND3chr6

41905132

-
5UTR-5UTRENST00000423325ENST00000372988SRPK1chr6

35888245

-CCND3chr6

41908323

-
5UTR-5UTRENST00000423325ENST00000372988SRPK1chr6

35888244

-CCND3chr6

41905132

-
5UTR-5UTRENST00000423325ENST00000372988SRPK1chr6

35888244

-CCND3chr6

41908323

-
5UTR-5UTRENST00000423325ENST00000372991SRPK1chr6

35888245

-CCND3chr6

41905132

-
5UTR-5UTRENST00000423325ENST00000372991SRPK1chr6

35888244

-CCND3chr6

41905132

-
5UTR-5UTRENST00000423325ENST00000414200SRPK1chr6

35888245

-CCND3chr6

41905132

-
5UTR-5UTRENST00000423325ENST00000414200SRPK1chr6

35888244

-CCND3chr6

41905132

-
5UTR-5UTRENST00000423325ENST00000415497SRPK1chr6

35888245

-CCND3chr6

41905132

-
5UTR-5UTRENST00000423325ENST00000415497SRPK1chr6

35888244

-CCND3chr6

41905132

-
5UTR-5UTRENST00000423325ENST00000510503SRPK1chr6

35888245

-CCND3chr6

41905132

-
5UTR-5UTRENST00000423325ENST00000510503SRPK1chr6

35888245

-CCND3chr6

41908323

-
5UTR-5UTRENST00000423325ENST00000510503SRPK1chr6

35888244

-CCND3chr6

41905132

-
5UTR-5UTRENST00000423325ENST00000510503SRPK1chr6

35888244

-CCND3chr6

41908323

-
5UTR-5UTRENST00000423325ENST00000511642SRPK1chr6

35888245

-CCND3chr6

41908323

-
5UTR-5UTRENST00000423325ENST00000511642SRPK1chr6

35888244

-CCND3chr6

41908323

-
5UTR-5UTRENST00000423325ENST00000511686SRPK1chr6

35888245

-CCND3chr6

41905132

-
5UTR-5UTRENST00000423325ENST00000511686SRPK1chr6

35888244

-CCND3chr6

41905132

-
5UTR-intronENST00000373822ENST00000372987SRPK1chr6

35888245

-CCND3chr6

41908323

-
5UTR-intronENST00000373822ENST00000372987SRPK1chr6

35888244

-CCND3chr6

41908323

-
5UTR-intronENST00000373822ENST00000372991SRPK1chr6

35888245

-CCND3chr6

41908323

-
5UTR-intronENST00000373822ENST00000372991SRPK1chr6

35888244

-CCND3chr6

41908323

-
5UTR-intronENST00000373822ENST00000414200SRPK1chr6

35888245

-CCND3chr6

41908323

-
5UTR-intronENST00000373822ENST00000414200SRPK1chr6

35888244

-CCND3chr6

41908323

-
5UTR-intronENST00000373822ENST00000415497SRPK1chr6

35888245

-CCND3chr6

41908323

-
5UTR-intronENST00000373822ENST00000415497SRPK1chr6

35888244

-CCND3chr6

41908323

-
5UTR-intronENST00000373822ENST00000511686SRPK1chr6

35888245

-CCND3chr6

41908323

-
5UTR-intronENST00000373822ENST00000511686SRPK1chr6

35888244

-CCND3chr6

41908323

-
5UTR-intronENST00000423325ENST00000372987SRPK1chr6

35888245

-CCND3chr6

41908323

-
5UTR-intronENST00000423325ENST00000372987SRPK1chr6

35888244

-CCND3chr6

41908323

-
5UTR-intronENST00000423325ENST00000372991SRPK1chr6

35888245

-CCND3chr6

41908323

-
5UTR-intronENST00000423325ENST00000372991SRPK1chr6

35888244

-CCND3chr6

41908323

-
5UTR-intronENST00000423325ENST00000414200SRPK1chr6

35888245

-CCND3chr6

41908323

-
5UTR-intronENST00000423325ENST00000414200SRPK1chr6

35888244

-CCND3chr6

41908323

-
5UTR-intronENST00000423325ENST00000415497SRPK1chr6

35888245

-CCND3chr6

41908323

-
5UTR-intronENST00000423325ENST00000415497SRPK1chr6

35888244

-CCND3chr6

41908323

-
5UTR-intronENST00000423325ENST00000511686SRPK1chr6

35888245

-CCND3chr6

41908323

-
5UTR-intronENST00000423325ENST00000511686SRPK1chr6

35888244

-CCND3chr6

41908323

-
Frame-shiftENST00000373825ENST00000511642SRPK1chr6

35888245

-CCND3chr6

41905132

-
Frame-shiftENST00000373825ENST00000511642SRPK1chr6

35888244

-CCND3chr6

41905132

-
intron-3CDSENST00000373821ENST00000511642SRPK1chr6

35888245

-CCND3chr6

41905132

-
intron-3CDSENST00000373821ENST00000511642SRPK1chr6

35888244

-CCND3chr6

41905132

-
intron-5UTRENST00000373821ENST00000372987SRPK1chr6

35888245

-CCND3chr6

41905132

-
intron-5UTRENST00000373821ENST00000372987SRPK1chr6

35888244

-CCND3chr6

41905132

-
intron-5UTRENST00000373821ENST00000372988SRPK1chr6

35888245

-CCND3chr6

41905132

-
intron-5UTRENST00000373821ENST00000372988SRPK1chr6

35888245

-CCND3chr6

41908323

-
intron-5UTRENST00000373821ENST00000372988SRPK1chr6

35888244

-CCND3chr6

41905132

-
intron-5UTRENST00000373821ENST00000372988SRPK1chr6

35888244

-CCND3chr6

41908323

-
intron-5UTRENST00000373821ENST00000372991SRPK1chr6

35888245

-CCND3chr6

41905132

-
intron-5UTRENST00000373821ENST00000372991SRPK1chr6

35888244

-CCND3chr6

41905132

-
intron-5UTRENST00000373821ENST00000414200SRPK1chr6

35888245

-CCND3chr6

41905132

-
intron-5UTRENST00000373821ENST00000414200SRPK1chr6

35888244

-CCND3chr6

41905132

-
intron-5UTRENST00000373821ENST00000415497SRPK1chr6

35888245

-CCND3chr6

41905132

-
intron-5UTRENST00000373821ENST00000415497SRPK1chr6

35888244

-CCND3chr6

41905132

-
intron-5UTRENST00000373821ENST00000510503SRPK1chr6

35888245

-CCND3chr6

41905132

-
intron-5UTRENST00000373821ENST00000510503SRPK1chr6

35888245

-CCND3chr6

41908323

-
intron-5UTRENST00000373821ENST00000510503SRPK1chr6

35888244

-CCND3chr6

41905132

-
intron-5UTRENST00000373821ENST00000510503SRPK1chr6

35888244

-CCND3chr6

41908323

-
intron-5UTRENST00000373821ENST00000511642SRPK1chr6

35888245

-CCND3chr6

41908323

-
intron-5UTRENST00000373821ENST00000511642SRPK1chr6

35888244

-CCND3chr6

41908323

-
intron-5UTRENST00000373821ENST00000511686SRPK1chr6

35888245

-CCND3chr6

41905132

-
intron-5UTRENST00000373821ENST00000511686SRPK1chr6

35888244

-CCND3chr6

41905132

-
intron-intronENST00000373821ENST00000372987SRPK1chr6

35888245

-CCND3chr6

41908323

-
intron-intronENST00000373821ENST00000372987SRPK1chr6

35888244

-CCND3chr6

41908323

-
intron-intronENST00000373821ENST00000372991SRPK1chr6

35888245

-CCND3chr6

41908323

-
intron-intronENST00000373821ENST00000372991SRPK1chr6

35888244

-CCND3chr6

41908323

-
intron-intronENST00000373821ENST00000414200SRPK1chr6

35888245

-CCND3chr6

41908323

-
intron-intronENST00000373821ENST00000414200SRPK1chr6

35888244

-CCND3chr6

41908323

-
intron-intronENST00000373821ENST00000415497SRPK1chr6

35888245

-CCND3chr6

41908323

-
intron-intronENST00000373821ENST00000415497SRPK1chr6

35888244

-CCND3chr6

41908323

-
intron-intronENST00000373821ENST00000511686SRPK1chr6

35888245

-CCND3chr6

41908323

-
intron-intronENST00000373821ENST00000511686SRPK1chr6

35888244

-CCND3chr6

41908323

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SRPK1-CCND3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SRPK1-CCND3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:35888245/:41908323)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CCND3

P30281

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. {ECO:0000269|PubMed:15358120}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SRPK1-CCND3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SRPK1-CCND3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SRPK1-CCND3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SRPK1-CCND3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource