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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
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Fusion gene:SRPK2-DYNC1I1 (FusionGDB2 ID:86496)

Fusion Gene Summary for SRPK2-DYNC1I1

Fusion gene summary

Fusion gene information	Fusion gene name: SRPK2-DYNC1I1
	Fusion gene ID: 86496
		Hgene	Tgene
	Gene symbol	SRPK2	DYNC1I1
	Gene ID	6733	1780
	Gene name	SRSF protein kinase 2	dynein cytoplasmic 1 intermediate chain 1
	Synonyms	SFRSK2	DNCI1\|DNCIC1
	Cytomap	7q22.3	7q21.3
	Type of gene	protein-coding	protein-coding
	Description	SRSF protein kinase 2SFRS protein kinase 2SR protein kinase 2SR-protein-specific kinase 2serine kinase SRPK2serine/arginine-rich protein-specific kinase 2serine/arginine-rich splicing factor kinase 2serine/threonine-protein kinase SRPK2	cytoplasmic dynein 1 intermediate chain 1DH IC-1cytoplasmic dynein intermediate chain 1dynein intermediate chain 1, cytosolicdynein, cytoplasmic, intermediate polypeptide 1
	Modification date	20200313	20200313
	UniProtAcc	.	O14576
	Ensembl transtripts involved in fusion gene	ENST00000393651, ENST00000357311, ENST00000489828, ENST00000493638,	ENST00000413338, ENST00000457059, ENST00000497626, ENST00000324972, ENST00000359388, ENST00000437599, ENST00000447467, ENST00000537881,
Fusion gene scores	* DoF score	18 X 14 X 10=2520	12 X 12 X 6=864
	# samples	20	13
	** MAII score	log2(20/2520*10)=-3.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/864*10)=-2.73251968913501 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SRPK2 [Title/Abstract] AND DYNC1I1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SRPK2(105029095)-DYNC1I1(95499195), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SRPK2	GO:0000245	spliceosomal complex assembly	9472028
Hgene	SRPK2	GO:0006468	protein phosphorylation	9472028
Hgene	SRPK2	GO:0008284	positive regulation of cell proliferation	18559500
Hgene	SRPK2	GO:0008380	RNA splicing	9472028
Hgene	SRPK2	GO:0035556	intracellular signal transduction	9472028
Hgene	SRPK2	GO:0045070	positive regulation of viral genome replication	20498328
Hgene	SRPK2	GO:0045071	negative regulation of viral genome replication	12417631

Fusion gene breakpoints across SRPK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DYNC1I1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-NJ-A4YQ-01A	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+

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Fusion Gene ORF analysis for SRPK2-DYNC1I1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000393651	ENST00000413338	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
5CDS-intron	ENST00000393651	ENST00000457059	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
5CDS-intron	ENST00000393651	ENST00000497626	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
In-frame	ENST00000393651	ENST00000324972	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
In-frame	ENST00000393651	ENST00000359388	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
In-frame	ENST00000393651	ENST00000437599	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
In-frame	ENST00000393651	ENST00000447467	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
In-frame	ENST00000393651	ENST00000537881	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
intron-3CDS	ENST00000357311	ENST00000324972	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
intron-3CDS	ENST00000357311	ENST00000359388	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
intron-3CDS	ENST00000357311	ENST00000437599	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
intron-3CDS	ENST00000357311	ENST00000447467	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
intron-3CDS	ENST00000357311	ENST00000537881	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
intron-3CDS	ENST00000489828	ENST00000324972	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
intron-3CDS	ENST00000489828	ENST00000359388	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
intron-3CDS	ENST00000489828	ENST00000437599	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
intron-3CDS	ENST00000489828	ENST00000447467	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
intron-3CDS	ENST00000489828	ENST00000537881	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
intron-3CDS	ENST00000493638	ENST00000324972	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
intron-3CDS	ENST00000493638	ENST00000359388	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
intron-3CDS	ENST00000493638	ENST00000437599	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
intron-3CDS	ENST00000493638	ENST00000447467	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
intron-3CDS	ENST00000493638	ENST00000537881	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
intron-intron	ENST00000357311	ENST00000413338	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
intron-intron	ENST00000357311	ENST00000457059	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
intron-intron	ENST00000357311	ENST00000497626	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
intron-intron	ENST00000489828	ENST00000413338	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
intron-intron	ENST00000489828	ENST00000457059	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
intron-intron	ENST00000489828	ENST00000497626	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
intron-intron	ENST00000493638	ENST00000413338	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
intron-intron	ENST00000493638	ENST00000457059	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+
intron-intron	ENST00000493638	ENST00000497626	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000393651	SRPK2	chr7	105029095	-	ENST00000447467	DYNC1I1	chr7	95499195	+	2503	159	88	1671	527
ENST00000393651	SRPK2	chr7	105029095	-	ENST00000324972	DYNC1I1	chr7	95499195	+	2491	159	88	1671	527
ENST00000393651	SRPK2	chr7	105029095	-	ENST00000537881	DYNC1I1	chr7	95499195	+	1905	159	88	1653	521
ENST00000393651	SRPK2	chr7	105029095	-	ENST00000437599	DYNC1I1	chr7	95499195	+	2503	159	88	1671	527
ENST00000393651	SRPK2	chr7	105029095	-	ENST00000359388	DYNC1I1	chr7	95499195	+	2503	159	88	1671	527

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000393651	ENST00000447467	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+	0.00023997	0.9997601
ENST00000393651	ENST00000324972	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+	0.000245357	0.9997546
ENST00000393651	ENST00000537881	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+	0.000361916	0.9996381
ENST00000393651	ENST00000437599	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+	0.00023997	0.9997601
ENST00000393651	ENST00000359388	SRPK2	chr7	105029095	-	DYNC1I1	chr7	95499195	+	0.00023997	0.9997601

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Fusion Genomic Features for SRPK2-DYNC1I1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
SRPK2	chr7	105029094	-	DYNC1I1	chr7	95499194	+	9.53E-05	0.99990463
SRPK2	chr7	105029094	-	DYNC1I1	chr7	95499194	+	9.53E-05	0.99990463

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SRPK2-DYNC1I1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:105029095/chr7:95499195)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	DYNC1I1 O14576
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000324972

285_334

141

646.0

Repeat

Note=WD 1

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000324972

338_378

141

646.0

Repeat

Note=WD 2

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000324972

387_428

141

646.0

Repeat

Note=WD 3

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000324972

437_477

141

646.0

Repeat

Note=WD 4

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000324972

482_527

141

646.0

Repeat

Note=WD 5

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000324972

530_570

141

646.0

Repeat

Note=WD 6

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000324972

576_615

141

646.0

Repeat

Note=WD 7

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000359388

285_334

104

609.0

Repeat

Note=WD 1

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000359388

338_378

104

609.0

Repeat

Note=WD 2

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000359388

387_428

104

609.0

Repeat

Note=WD 3

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000359388

437_477

104

609.0

Repeat

Note=WD 4

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000359388

482_527

104

609.0

Repeat

Note=WD 5

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000359388

530_570

104

609.0

Repeat

Note=WD 6

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000359388

576_615

104

609.0

Repeat

Note=WD 7

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000447467

285_334

124

629.0

Repeat

Note=WD 1

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000447467

338_378

124

629.0

Repeat

Note=WD 2

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000447467

387_428

124

629.0

Repeat

Note=WD 3

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000447467

437_477

124

629.0

Repeat

Note=WD 4

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000447467

482_527

124

629.0

Repeat

Note=WD 5

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000447467

530_570

124

629.0

Repeat

Note=WD 6

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000447467

576_615

124

629.0

Repeat

Note=WD 7

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000457059

285_334

124

629.0

Repeat

Note=WD 1

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000457059

338_378

124

629.0

Repeat

Note=WD 2

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000457059

387_428

124

629.0

Repeat

Note=WD 3

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000457059

437_477

124

629.0

Repeat

Note=WD 4

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000457059

482_527

124

629.0

Repeat

Note=WD 5

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000457059

530_570

124

629.0

Repeat

Note=WD 6

Tgene

DYNC1I1

chr7:105029095

chr7:95499195

ENST00000457059

576_615

124

629.0

Repeat

Note=WD 7

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SRPK2

chr7:105029095

chr7:95499195

ENST00000357311

81_684

689.0

Domain

Protein kinase

Hgene

SRPK2

chr7:105029095

chr7:95499195

ENST00000393651

81_684

700.0

Domain

Protein kinase

Hgene

SRPK2

chr7:105029095

chr7:95499195

ENST00000489828

81_684

689.0

Domain

Protein kinase

Hgene

SRPK2

chr7:105029095

chr7:95499195

ENST00000357311

87_95

689.0

Nucleotide binding

ATP

Hgene

SRPK2

chr7:105029095

chr7:95499195

ENST00000393651

87_95

700.0

Nucleotide binding

ATP

Hgene

SRPK2

chr7:105029095

chr7:95499195

ENST00000489828

87_95

689.0

Nucleotide binding

ATP

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Fusion Gene Sequence for SRPK2-DYNC1I1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>86496_86496_1_SRPK2-DYNC1I1_SRPK2_chr7_105029095_ENST00000393651_DYNC1I1_chr7_95499195_ENST00000324972_length(transcript)=2491nt_BP=159nt
GGCGGAGCGAGTGGAGGCTGCAGCCCAGCTCGTCTCGGCGCCCGCGTCGCCGTCGCGAAGCCCCCCGCCCCGCTTCCGCCGCGTCGGAAT
GAGCTCCCGGAAAGTGCTGGCCATTCAGGCCCGAAAGCGGAGGCCGAAAAGAGAGAAACATCCGAAAAAAAGAAGACTGCATAAACTGGG
CGTGTCAAAGGTCACCCAAGTGGATTTCCTGCCAAGGGAAGTAGTGTCCTACTCAAAGGAGACCCAGACTCCTCTTGCCACGCATCAGTC
TGAAGAGGATGAGGAAGATGAGGAAATGGTGGAATCTAAAGTTGGCCAGGACTCAGAACTGGAAAATCAGGACAAAAAACAGGAAGTGAA
GGAAGCCCCTCCAAGAGAGTTGACAGAGGAAGAAAAACAGCAGATCCTTCATTCAGAGGAATTTCTCATCTTTTTTGACCGGACAATACG
GGTAATTGAAAGAGCCCTGGCTGAAGATTCCGACATCTTTTTTGACTACAGCGGCCGAGAGTTAGAGGAAAAAGATGGGGATGTTCAGGC
TGGAGCCAATCTTTCTTTCAATCGTCAGTTCTATGATGAACATTGGTCCAAGCATCGAGTGGTCACTTGTATGGACTGGTCCCTCCAGTA
CCCTGAGCTGATGGTGGCTTCTTACAACAACAATGAAGATGCTCCCCATGAACCAGATGGAGTGGCCTTGGTTTGGAACATGAAGTTTAA
GAAAACCACACCAGAATACGTCTTCCACTGTCAGTCCTCTGTGATGTCGGTCTGCTTCGCCCGTTTCCATCCTAACTTGGTGGTTGGTGG
GACTTACTCGGGCCAGATTGTCCTCTGGGACAATCGCAGTCATCGAAGGACTCCAGTGCAGCGGACACCCTTATCAGCTGCTGCACACAC
GCATCCCGTGTACTGTGTAAATGTTGTTGGGACCCAGAATGCTCATAACCTCATCACTGTCTCCACTGATGGCAAAATGTGTTCCTGGAG
CCTGGACATGCTCTCAACTCCACAGGAGAGCATGGAGCTGGTGTACAATAAGTCCAAGCCTGTCGCTGTTACCGGAATGGCTTTCCCAAC
GGGAGACGTCAATAACTTCGTGGTTGGCAGTGAGGAAGGTACAGTCTACACGGCTTGTCGTCATGGAAGCAAAGCAGGTATTGGTGAGGT
CTTTGAAGGTCACCAAGGGCCAGTGACAGGAATTAACTGCCACATGGCAGTGGGCCCAATCGACTTTTCTCACCTGTTTGTCACATCATC
ATTTGACTGGACTGTCAAACTGTGGACCACCAAGCACAACAAGCCGCTCTACTCCTTTGAAGACAATGCAGACTATGTGTACGATGTCAT
GTGGTCCCCCGTGCATCCTGCGCTTTTTGCCTGCGTGGACGGGATGGGGCGCTTGGACCTCTGGAACCTCAACAATGACACCGAGGTTCC
AACAGCAAGTGTGGCCATTGAGGGGGCATCCGCCCTAAACCGTGTTCGTTGGGCCCAAGCTGGCAAAGAAGTTGCTGTTGGGGACTCGGA
AGGCCGTATTTGGGTCTATGACGTTGGAGAGCTTGCAGTTCCCCACAATGATGAATGGACCCGATTTGCCAGGACCCTTGTGGAAATTCG
TGCTAACAGAGCTGATAGCGAGGAGGAAGGCACTGTTGAGTTATCTGCCTAGTGGAAATGAGCCACCCCCACTGCAGCCCCCACCTTTGT
GTCCTAGAGCTCAGCGTCTGCAGTCAAGTCTCTTGTATTCGGTGTCCATTCAGTATCAGTATTGCTGTGATATTTTGGGTGCCATATTGT
GCCAGCTTTGCTCCAAGTATTCTAAATGTGTCCCATCATGCTTTCCACTGACCCAAAATTCACCACAGCATTTCTATCTTTATATTTCTG
TCTCAAAAATGAAGAGAAGGGGGTTATGGGTTAAGTTGCTGCCTTTTAACTACTTTGTAGCTGTATTTAATAGCTGGAAACCTCTGGTTA
AATTTGTGCTTACATGCACTCCTGGCATAGTCCTATTAAATCCATATGAAGCCAGATATGATTGGGTGCAGATGTGGTGTTCCTCATATT
ATGGTACAGGGCCAAAGACTTGAGACGTGGTGTTTTACATGGTGACTCACATTATGAATGGATTTACTAGAAGAACATTGCTGCTCCTTA
TTTATTGTAGTGTGCTGCATGGAACGTATTTATTTGAAAGCATTAAAATAAATGATCCTAGAGCATGTGCATAATGAGAGGACTGTATTC
TCTCTGCTGCTGTTGAGGTTATATTAAGTTCCACATAGCAATTACAGTATGCCAGTTCCACTGAAGACATGAAATCTTTAGAGGTTTCTT
GCAGTGAACGAAATGAATTTTAATGCCTATTATTTCTGGGTACTTTAACAATATTTCAAATATCATTGACCACTAATACTTCTCACTGAA

>86496_86496_1_SRPK2-DYNC1I1_SRPK2_chr7_105029095_ENST00000393651_DYNC1I1_chr7_95499195_ENST00000324972_length(amino acids)=527AA_BP=24
MSSRKVLAIQARKRRPKREKHPKKRRLHKLGVSKVTQVDFLPREVVSYSKETQTPLATHQSEEDEEDEEMVESKVGQDSELENQDKKQEV
KEAPPRELTEEEKQQILHSEEFLIFFDRTIRVIERALAEDSDIFFDYSGRELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQ
YPELMVASYNNNEDAPHEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAH
THPVYCVNVVGTQNAHNLITVSTDGKMCSWSLDMLSTPQESMELVYNKSKPVAVTGMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGE
VFEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWTTKHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEV

--------------------------------------------------------------
>86496_86496_2_SRPK2-DYNC1I1_SRPK2_chr7_105029095_ENST00000393651_DYNC1I1_chr7_95499195_ENST00000359388_length(transcript)=2503nt_BP=159nt
GGCGGAGCGAGTGGAGGCTGCAGCCCAGCTCGTCTCGGCGCCCGCGTCGCCGTCGCGAAGCCCCCCGCCCCGCTTCCGCCGCGTCGGAAT
GAGCTCCCGGAAAGTGCTGGCCATTCAGGCCCGAAAGCGGAGGCCGAAAAGAGAGAAACATCCGAAAAAAAGAAGACTGCATAAACTGGG
CGTGTCAAAGGTCACCCAAGTGGATTTCCTGCCAAGGGAAGTAGTGTCCTACTCAAAGGAGACCCAGACTCCTCTTGCCACGCATCAGTC
TGAAGAGGATGAGGAAGATGAGGAAATGGTGGAATCTAAAGTTGGCCAGGACTCAGAACTGGAAAATCAGGACAAAAAACAGGAAGTGAA
GGAAGCCCCTCCAAGAGAGTTGACAGAGGAAGAAAAACAGCAGATCCTTCATTCAGAGGAATTTCTCATCTTTTTTGACCGGACAATACG
GGTAATTGAAAGAGCCCTGGCTGAAGATTCCGACATCTTTTTTGACTACAGCGGCCGAGAGTTAGAGGAAAAAGATGGGGATGTTCAGGC
TGGAGCCAATCTTTCTTTCAATCGTCAGTTCTATGATGAACATTGGTCCAAGCATCGAGTGGTCACTTGTATGGACTGGTCCCTCCAGTA
CCCTGAGCTGATGGTGGCTTCTTACAACAACAATGAAGATGCTCCCCATGAACCAGATGGAGTGGCCTTGGTTTGGAACATGAAGTTTAA
GAAAACCACACCAGAATACGTCTTCCACTGTCAGTCCTCTGTGATGTCGGTCTGCTTCGCCCGTTTCCATCCTAACTTGGTGGTTGGTGG
GACTTACTCGGGCCAGATTGTCCTCTGGGACAATCGCAGTCATCGAAGGACTCCAGTGCAGCGGACACCCTTATCAGCTGCTGCACACAC
GCATCCCGTGTACTGTGTAAATGTTGTTGGGACCCAGAATGCTCATAACCTCATCACTGTCTCCACTGATGGCAAAATGTGTTCCTGGAG
CCTGGACATGCTCTCAACTCCACAGGAGAGCATGGAGCTGGTGTACAATAAGTCCAAGCCTGTCGCTGTTACCGGAATGGCTTTCCCAAC
GGGAGACGTCAATAACTTCGTGGTTGGCAGTGAGGAAGGTACAGTCTACACGGCTTGTCGTCATGGAAGCAAAGCAGGTATTGGTGAGGT
CTTTGAAGGTCACCAAGGGCCAGTGACAGGAATTAACTGCCACATGGCAGTGGGCCCAATCGACTTTTCTCACCTGTTTGTCACATCATC
ATTTGACTGGACTGTCAAACTGTGGACCACCAAGCACAACAAGCCGCTCTACTCCTTTGAAGACAATGCAGACTATGTGTACGATGTCAT
GTGGTCCCCCGTGCATCCTGCGCTTTTTGCCTGCGTGGACGGGATGGGGCGCTTGGACCTCTGGAACCTCAACAATGACACCGAGGTTCC
AACAGCAAGTGTGGCCATTGAGGGGGCATCCGCCCTAAACCGTGTTCGTTGGGCCCAAGCTGGCAAAGAAGTTGCTGTTGGGGACTCGGA
AGGCCGTATTTGGGTCTATGACGTTGGAGAGCTTGCAGTTCCCCACAATGATGAATGGACCCGATTTGCCAGGACCCTTGTGGAAATTCG
TGCTAACAGAGCTGATAGCGAGGAGGAAGGCACTGTTGAGTTATCTGCCTAGTGGAAATGAGCCACCCCCACTGCAGCCCCCACCTTTGT
GTCCTAGAGCTCAGCGTCTGCAGTCAAGTCTCTTGTATTCGGTGTCCATTCAGTATCAGTATTGCTGTGATATTTTGGGTGCCATATTGT
GCCAGCTTTGCTCCAAGTATTCTAAATGTGTCCCATCATGCTTTCCACTGACCCAAAATTCACCACAGCATTTCTATCTTTATATTTCTG
TCTCAAAAATGAAGAGAAGGGGGTTATGGGTTAAGTTGCTGCCTTTTAACTACTTTGTAGCTGTATTTAATAGCTGGAAACCTCTGGTTA
AATTTGTGCTTACATGCACTCCTGGCATAGTCCTATTAAATCCATATGAAGCCAGATATGATTGGGTGCAGATGTGGTGTTCCTCATATT
ATGGTACAGGGCCAAAGACTTGAGACGTGGTGTTTTACATGGTGACTCACATTATGAATGGATTTACTAGAAGAACATTGCTGCTCCTTA
TTTATTGTAGTGTGCTGCATGGAACGTATTTATTTGAAAGCATTAAAATAAATGATCCTAGAGCATGTGCATAATGAGAGGACTGTATTC
TCTCTGCTGCTGTTGAGGTTATATTAAGTTCCACATAGCAATTACAGTATGCCAGTTCCACTGAAGACATGAAATCTTTAGAGGTTTCTT
GCAGTGAACGAAATGAATTTTAATGCCTATTATTTCTGGGTACTTTAACAATATTTCAAATATCATTGACCACTAATACTTCTCACTGAA

>86496_86496_2_SRPK2-DYNC1I1_SRPK2_chr7_105029095_ENST00000393651_DYNC1I1_chr7_95499195_ENST00000359388_length(amino acids)=527AA_BP=24
MSSRKVLAIQARKRRPKREKHPKKRRLHKLGVSKVTQVDFLPREVVSYSKETQTPLATHQSEEDEEDEEMVESKVGQDSELENQDKKQEV
KEAPPRELTEEEKQQILHSEEFLIFFDRTIRVIERALAEDSDIFFDYSGRELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQ
YPELMVASYNNNEDAPHEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAH
THPVYCVNVVGTQNAHNLITVSTDGKMCSWSLDMLSTPQESMELVYNKSKPVAVTGMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGE
VFEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWTTKHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEV

--------------------------------------------------------------
>86496_86496_3_SRPK2-DYNC1I1_SRPK2_chr7_105029095_ENST00000393651_DYNC1I1_chr7_95499195_ENST00000437599_length(transcript)=2503nt_BP=159nt
GGCGGAGCGAGTGGAGGCTGCAGCCCAGCTCGTCTCGGCGCCCGCGTCGCCGTCGCGAAGCCCCCCGCCCCGCTTCCGCCGCGTCGGAAT
GAGCTCCCGGAAAGTGCTGGCCATTCAGGCCCGAAAGCGGAGGCCGAAAAGAGAGAAACATCCGAAAAAAAGAAGACTGCATAAACTGGG
CGTGTCAAAGGTCACCCAAGTGGATTTCCTGCCAAGGGAAGTAGTGTCCTACTCAAAGGAGACCCAGACTCCTCTTGCCACGCATCAGTC
TGAAGAGGATGAGGAAGATGAGGAAATGGTGGAATCTAAAGTTGGCCAGGACTCAGAACTGGAAAATCAGGACAAAAAACAGGAAGTGAA
GGAAGCCCCTCCAAGAGAGTTGACAGAGGAAGAAAAACAGCAGATCCTTCATTCAGAGGAATTTCTCATCTTTTTTGACCGGACAATACG
GGTAATTGAAAGAGCCCTGGCTGAAGATTCCGACATCTTTTTTGACTACAGCGGCCGAGAGTTAGAGGAAAAAGATGGGGATGTTCAGGC
TGGAGCCAATCTTTCTTTCAATCGTCAGTTCTATGATGAACATTGGTCCAAGCATCGAGTGGTCACTTGTATGGACTGGTCCCTCCAGTA
CCCTGAGCTGATGGTGGCTTCTTACAACAACAATGAAGATGCTCCCCATGAACCAGATGGAGTGGCCTTGGTTTGGAACATGAAGTTTAA
GAAAACCACACCAGAATACGTCTTCCACTGTCAGTCCTCTGTGATGTCGGTCTGCTTCGCCCGTTTCCATCCTAACTTGGTGGTTGGTGG
GACTTACTCGGGCCAGATTGTCCTCTGGGACAATCGCAGTCATCGAAGGACTCCAGTGCAGCGGACACCCTTATCAGCTGCTGCACACAC
GCATCCCGTGTACTGTGTAAATGTTGTTGGGACCCAGAATGCTCATAACCTCATCACTGTCTCCACTGATGGCAAAATGTGTTCCTGGAG
CCTGGACATGCTCTCAACTCCACAGGAGAGCATGGAGCTGGTGTACAATAAGTCCAAGCCTGTCGCTGTTACCGGAATGGCTTTCCCAAC
GGGAGACGTCAATAACTTCGTGGTTGGCAGTGAGGAAGGTACAGTCTACACGGCTTGTCGTCATGGAAGCAAAGCAGGTATTGGTGAGGT
CTTTGAAGGTCACCAAGGGCCAGTGACAGGAATTAACTGCCACATGGCAGTGGGCCCAATCGACTTTTCTCACCTGTTTGTCACATCATC
ATTTGACTGGACTGTCAAACTGTGGACCACCAAGCACAACAAGCCGCTCTACTCCTTTGAAGACAATGCAGACTATGTGTACGATGTCAT
GTGGTCCCCCGTGCATCCTGCGCTTTTTGCCTGCGTGGACGGGATGGGGCGCTTGGACCTCTGGAACCTCAACAATGACACCGAGGTTCC
AACAGCAAGTGTGGCCATTGAGGGGGCATCCGCCCTAAACCGTGTTCGTTGGGCCCAAGCTGGCAAAGAAGTTGCTGTTGGGGACTCGGA
AGGCCGTATTTGGGTCTATGACGTTGGAGAGCTTGCAGTTCCCCACAATGATGAATGGACCCGATTTGCCAGGACCCTTGTGGAAATTCG
TGCTAACAGAGCTGATAGCGAGGAGGAAGGCACTGTTGAGTTATCTGCCTAGTGGAAATGAGCCACCCCCACTGCAGCCCCCACCTTTGT
GTCCTAGAGCTCAGCGTCTGCAGTCAAGTCTCTTGTATTCGGTGTCCATTCAGTATCAGTATTGCTGTGATATTTTGGGTGCCATATTGT
GCCAGCTTTGCTCCAAGTATTCTAAATGTGTCCCATCATGCTTTCCACTGACCCAAAATTCACCACAGCATTTCTATCTTTATATTTCTG
TCTCAAAAATGAAGAGAAGGGGGTTATGGGTTAAGTTGCTGCCTTTTAACTACTTTGTAGCTGTATTTAATAGCTGGAAACCTCTGGTTA
AATTTGTGCTTACATGCACTCCTGGCATAGTCCTATTAAATCCATATGAAGCCAGATATGATTGGGTGCAGATGTGGTGTTCCTCATATT
ATGGTACAGGGCCAAAGACTTGAGACGTGGTGTTTTACATGGTGACTCACATTATGAATGGATTTACTAGAAGAACATTGCTGCTCCTTA
TTTATTGTAGTGTGCTGCATGGAACGTATTTATTTGAAAGCATTAAAATAAATGATCCTAGAGCATGTGCATAATGAGAGGACTGTATTC
TCTCTGCTGCTGTTGAGGTTATATTAAGTTCCACATAGCAATTACAGTATGCCAGTTCCACTGAAGACATGAAATCTTTAGAGGTTTCTT
GCAGTGAACGAAATGAATTTTAATGCCTATTATTTCTGGGTACTTTAACAATATTTCAAATATCATTGACCACTAATACTTCTCACTGAA

>86496_86496_3_SRPK2-DYNC1I1_SRPK2_chr7_105029095_ENST00000393651_DYNC1I1_chr7_95499195_ENST00000437599_length(amino acids)=527AA_BP=24
MSSRKVLAIQARKRRPKREKHPKKRRLHKLGVSKVTQVDFLPREVVSYSKETQTPLATHQSEEDEEDEEMVESKVGQDSELENQDKKQEV
KEAPPRELTEEEKQQILHSEEFLIFFDRTIRVIERALAEDSDIFFDYSGRELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQ
YPELMVASYNNNEDAPHEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAH
THPVYCVNVVGTQNAHNLITVSTDGKMCSWSLDMLSTPQESMELVYNKSKPVAVTGMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGE
VFEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWTTKHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEV

--------------------------------------------------------------
>86496_86496_4_SRPK2-DYNC1I1_SRPK2_chr7_105029095_ENST00000393651_DYNC1I1_chr7_95499195_ENST00000447467_length(transcript)=2503nt_BP=159nt
GGCGGAGCGAGTGGAGGCTGCAGCCCAGCTCGTCTCGGCGCCCGCGTCGCCGTCGCGAAGCCCCCCGCCCCGCTTCCGCCGCGTCGGAAT
GAGCTCCCGGAAAGTGCTGGCCATTCAGGCCCGAAAGCGGAGGCCGAAAAGAGAGAAACATCCGAAAAAAAGAAGACTGCATAAACTGGG
CGTGTCAAAGGTCACCCAAGTGGATTTCCTGCCAAGGGAAGTAGTGTCCTACTCAAAGGAGACCCAGACTCCTCTTGCCACGCATCAGTC
TGAAGAGGATGAGGAAGATGAGGAAATGGTGGAATCTAAAGTTGGCCAGGACTCAGAACTGGAAAATCAGGACAAAAAACAGGAAGTGAA
GGAAGCCCCTCCAAGAGAGTTGACAGAGGAAGAAAAACAGCAGATCCTTCATTCAGAGGAATTTCTCATCTTTTTTGACCGGACAATACG
GGTAATTGAAAGAGCCCTGGCTGAAGATTCCGACATCTTTTTTGACTACAGCGGCCGAGAGTTAGAGGAAAAAGATGGGGATGTTCAGGC
TGGAGCCAATCTTTCTTTCAATCGTCAGTTCTATGATGAACATTGGTCCAAGCATCGAGTGGTCACTTGTATGGACTGGTCCCTCCAGTA
CCCTGAGCTGATGGTGGCTTCTTACAACAACAATGAAGATGCTCCCCATGAACCAGATGGAGTGGCCTTGGTTTGGAACATGAAGTTTAA
GAAAACCACACCAGAATACGTCTTCCACTGTCAGTCCTCTGTGATGTCGGTCTGCTTCGCCCGTTTCCATCCTAACTTGGTGGTTGGTGG
GACTTACTCGGGCCAGATTGTCCTCTGGGACAATCGCAGTCATCGAAGGACTCCAGTGCAGCGGACACCCTTATCAGCTGCTGCACACAC
GCATCCCGTGTACTGTGTAAATGTTGTTGGGACCCAGAATGCTCATAACCTCATCACTGTCTCCACTGATGGCAAAATGTGTTCCTGGAG
CCTGGACATGCTCTCAACTCCACAGGAGAGCATGGAGCTGGTGTACAATAAGTCCAAGCCTGTCGCTGTTACCGGAATGGCTTTCCCAAC
GGGAGACGTCAATAACTTCGTGGTTGGCAGTGAGGAAGGTACAGTCTACACGGCTTGTCGTCATGGAAGCAAAGCAGGTATTGGTGAGGT
CTTTGAAGGTCACCAAGGGCCAGTGACAGGAATTAACTGCCACATGGCAGTGGGCCCAATCGACTTTTCTCACCTGTTTGTCACATCATC
ATTTGACTGGACTGTCAAACTGTGGACCACCAAGCACAACAAGCCGCTCTACTCCTTTGAAGACAATGCAGACTATGTGTACGATGTCAT
GTGGTCCCCCGTGCATCCTGCGCTTTTTGCCTGCGTGGACGGGATGGGGCGCTTGGACCTCTGGAACCTCAACAATGACACCGAGGTTCC
AACAGCAAGTGTGGCCATTGAGGGGGCATCCGCCCTAAACCGTGTTCGTTGGGCCCAAGCTGGCAAAGAAGTTGCTGTTGGGGACTCGGA
AGGCCGTATTTGGGTCTATGACGTTGGAGAGCTTGCAGTTCCCCACAATGATGAATGGACCCGATTTGCCAGGACCCTTGTGGAAATTCG
TGCTAACAGAGCTGATAGCGAGGAGGAAGGCACTGTTGAGTTATCTGCCTAGTGGAAATGAGCCACCCCCACTGCAGCCCCCACCTTTGT
GTCCTAGAGCTCAGCGTCTGCAGTCAAGTCTCTTGTATTCGGTGTCCATTCAGTATCAGTATTGCTGTGATATTTTGGGTGCCATATTGT
GCCAGCTTTGCTCCAAGTATTCTAAATGTGTCCCATCATGCTTTCCACTGACCCAAAATTCACCACAGCATTTCTATCTTTATATTTCTG
TCTCAAAAATGAAGAGAAGGGGGTTATGGGTTAAGTTGCTGCCTTTTAACTACTTTGTAGCTGTATTTAATAGCTGGAAACCTCTGGTTA
AATTTGTGCTTACATGCACTCCTGGCATAGTCCTATTAAATCCATATGAAGCCAGATATGATTGGGTGCAGATGTGGTGTTCCTCATATT
ATGGTACAGGGCCAAAGACTTGAGACGTGGTGTTTTACATGGTGACTCACATTATGAATGGATTTACTAGAAGAACATTGCTGCTCCTTA
TTTATTGTAGTGTGCTGCATGGAACGTATTTATTTGAAAGCATTAAAATAAATGATCCTAGAGCATGTGCATAATGAGAGGACTGTATTC
TCTCTGCTGCTGTTGAGGTTATATTAAGTTCCACATAGCAATTACAGTATGCCAGTTCCACTGAAGACATGAAATCTTTAGAGGTTTCTT
GCAGTGAACGAAATGAATTTTAATGCCTATTATTTCTGGGTACTTTAACAATATTTCAAATATCATTGACCACTAATACTTCTCACTGAA

>86496_86496_4_SRPK2-DYNC1I1_SRPK2_chr7_105029095_ENST00000393651_DYNC1I1_chr7_95499195_ENST00000447467_length(amino acids)=527AA_BP=24
MSSRKVLAIQARKRRPKREKHPKKRRLHKLGVSKVTQVDFLPREVVSYSKETQTPLATHQSEEDEEDEEMVESKVGQDSELENQDKKQEV
KEAPPRELTEEEKQQILHSEEFLIFFDRTIRVIERALAEDSDIFFDYSGRELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQ
YPELMVASYNNNEDAPHEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAH
THPVYCVNVVGTQNAHNLITVSTDGKMCSWSLDMLSTPQESMELVYNKSKPVAVTGMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGE
VFEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWTTKHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEV

--------------------------------------------------------------
>86496_86496_5_SRPK2-DYNC1I1_SRPK2_chr7_105029095_ENST00000393651_DYNC1I1_chr7_95499195_ENST00000537881_length(transcript)=1905nt_BP=159nt
GGCGGAGCGAGTGGAGGCTGCAGCCCAGCTCGTCTCGGCGCCCGCGTCGCCGTCGCGAAGCCCCCCGCCCCGCTTCCGCCGCGTCGGAAT
GAGCTCCCGGAAAGTGCTGGCCATTCAGGCCCGAAAGCGGAGGCCGAAAAGAGAGAAACATCCGAAAAAAAGAAGACTGCATAAACTGGG
CGTGTCAAAGGTCACCCAAGTGGATTTCCTGCCAAGGGAAGTAGTGTCCTACTCAAAGGAGACCCAGACTCCTCTTGCCACGCATCAGTC
TGAAGAGGATGAGGAAGATGAGGAAATGGTGGAATCTAAAGTTGGCCAGGACTCAGAACTGGAAAATCAGGACAAAAAACAGGAAGTGAA
GGAAGCCCCTCCAAGAGAGTTGACAGAGGAAGAAAAACAGCAGATCCTTCATTCAGAGGAATTTCTCATCTTTTTTGACCGGACAATACG
GGTAATTGAAAGAGCCCTGGCTGAAGATTCCGACATCTTTTTTGACTACAGCGGCCGAGAGTTAGAGGAAAAAGATGGGGATGTTCAGGC
TGGAGCCAATCTTTCTTTCAATCGTCAGTTCTATGATGAACATTGGTCCAAGCATCGAGTGGTCACTTGTATGGACTGGTCCCTCCAGTA
CCCTGAGCTGATGGTGGCTTCTTACAACAACAATGAAGATGCTCCCCATGAACCAGATGGAGTGGCCTTGGTTTGGAACATGAAGTTTAA
GAAAACCACACCAGAATACGTCTTCCACTGTCAGTCCTCTGTGATGTCGGTCTGCTTCGCCCGTTTCCATCCTAACTTGGTGGTTGGTGG
GACTTACTCGGGCCAGATTGTCCTCTGGGACAATCGCAGTCATCGAAGGACTCCAGTGCAGCGGACACCCTTATCAGCTGCTGCACACAC
GCATCCCGTGTACTGTGTAAATGTTGTTGGGACCCAGAATGCTCATAACCTCATCACTGTCTCCACTGATGGCAAAATGTGTTCCTGGAG
CCTGGACATGCTCTCAACTCCACAGGAGAGCATGGAGCTGGTGTACAATAAGTCCAAGCCTGTCGCTGTTACCGGAATGGCTTTCCCAAC
GGGAGACGTCAATAACTTCGTGGTTGGCAGTGAGGAAGGTACAGTCTACACGGCTTGTCGTCATGGAAGCAAAGCAGGTATTGGTGAGGT
CTTTGAAGGTCACCAAGGGCCAGTGACAGGAATTAACTGCCACATGGCAGTGGGCCCAATCGACTTTTCTCACCTGTTTGTCACATCATC
ATTTGACTGGACTGTCAAACTGTGGACCACCAAGCACAACAAGCCGCTCTACTCCTTTGAAGACAATGCAGACTATGTGTACGATGTCAT
GTGGTCCCCCGTGCATCCTGCGCTTTTTGCCTGCGTGGACGGGATGGGGCGCTTGGACCTCTGGAACCTCAACAATGACACCGAGGTTCC
AACAGCAAGTGTGGCCATTGAGGGGGCATCCGCCCTAAACCGTGTTCGTTGGGCCCAAGCTGGCAAAGAAGTTGCTGTTGGGGACTCGGA
AGGCCGTATTTGGGTCTATGACGTTGGAGAGGGTCTTGCTATGTTGCCAGGCTGGTCTCAAAATTCCTGGACTCAAGCAATCCTCCTATG
TTGGCCTCCCAAAGTGCTGGGATTACAGACATGAGCCACTGTGCCCAGCTATGCCTGCTTGTTATATCAGCTACTGAGAGATGAGTACCA
AAATCTGGAAGTATAATTGTGGATATCTTTTAGTTCTTTCAGTTCTATCAGCTTTTGTTTTCTGTATCCAAAGCTTTGTTATTAGGTGCC
TACATATTGAGGATTTCATGTGTTTGCGATGAACTGACCCTTTTATCAATATGAAATGTTGCTGTTTATTCCTAGTAATAATCCTTTTTC

>86496_86496_5_SRPK2-DYNC1I1_SRPK2_chr7_105029095_ENST00000393651_DYNC1I1_chr7_95499195_ENST00000537881_length(amino acids)=521AA_BP=24
MSSRKVLAIQARKRRPKREKHPKKRRLHKLGVSKVTQVDFLPREVVSYSKETQTPLATHQSEEDEEDEEMVESKVGQDSELENQDKKQEV
KEAPPRELTEEEKQQILHSEEFLIFFDRTIRVIERALAEDSDIFFDYSGRELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQ
YPELMVASYNNNEDAPHEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAH
THPVYCVNVVGTQNAHNLITVSTDGKMCSWSLDMLSTPQESMELVYNKSKPVAVTGMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGE
VFEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWTTKHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEV

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SRPK2-DYNC1I1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	DYNC1I1	chr7:105029095	chr7:95499195	ENST00000324972		4	17	147_163	141.66666666666666	646.0	DYNLT1
Tgene	DYNC1I1	chr7:105029095	chr7:95499195	ENST00000359388		3	16	147_163	104.66666666666667	609.0	DYNLT1
Tgene	DYNC1I1	chr7:105029095	chr7:95499195	ENST00000447467		4	17	147_163	124.66666666666667	629.0	DYNLT1
Tgene	DYNC1I1	chr7:105029095	chr7:95499195	ENST00000457059		4	17	147_163	124.66666666666667	629.0	DYNLT1

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	DYNC1I1	chr7:105029095	chr7:95499195	ENST00000324972		4	17	2_123	141.66666666666666	646.0	DCTN1
Tgene	DYNC1I1	chr7:105029095	chr7:95499195	ENST00000359388		3	16	2_123	104.66666666666667	609.0	DCTN1
Tgene	DYNC1I1	chr7:105029095	chr7:95499195	ENST00000447467		4	17	2_123	124.66666666666667	629.0	DCTN1
Tgene	DYNC1I1	chr7:105029095	chr7:95499195	ENST00000457059		4	17	2_123	124.66666666666667	629.0	DCTN1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for SRPK2-DYNC1I1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for SRPK2-DYNC1I1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source