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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SRPK2-PRKAR2B (FusionGDB2 ID:86510)

Fusion Gene Summary for SRPK2-PRKAR2B

check button Fusion gene summary
Fusion gene informationFusion gene name: SRPK2-PRKAR2B
Fusion gene ID: 86510
HgeneTgene
Gene symbol

SRPK2

PRKAR2B

Gene ID

6733

5577

Gene nameSRSF protein kinase 2protein kinase cAMP-dependent type II regulatory subunit beta
SynonymsSFRSK2PRKAR2|RII-BETA
Cytomap

7q22.3

7q22.3

Type of geneprotein-codingprotein-coding
DescriptionSRSF protein kinase 2SFRS protein kinase 2SR protein kinase 2SR-protein-specific kinase 2serine kinase SRPK2serine/arginine-rich protein-specific kinase 2serine/arginine-rich splicing factor kinase 2serine/threonine-protein kinase SRPK2cAMP-dependent protein kinase type II-beta regulatory subunitH_RG363E19.2WUGSC:H_RG363E19.2cAMP-dependent protein kinase type II-beta regulatory chainprotein kinase, cAMP-dependent, regulatory subunit type II betaprotein kinase, cAMP-dependent, regul
Modification date2020031320200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000357311, ENST00000393651, 
ENST00000489828, ENST00000493638, 
ENST00000393613, ENST00000265717, 
Fusion gene scores* DoF score18 X 14 X 10=25207 X 6 X 5=210
# samples 208
** MAII scorelog2(20/2520*10)=-3.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SRPK2 [Title/Abstract] AND PRKAR2B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSRPK2(104800954)-PRKAR2B(106791367), # samples:3
Anticipated loss of major functional domain due to fusion event.SRPK2-PRKAR2B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SRPK2-PRKAR2B seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
SRPK2-PRKAR2B seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
SRPK2-PRKAR2B seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
SRPK2-PRKAR2B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
SRPK2-PRKAR2B seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSRPK2

GO:0000245

spliceosomal complex assembly

9472028

HgeneSRPK2

GO:0006468

protein phosphorylation

9472028

HgeneSRPK2

GO:0008284

positive regulation of cell proliferation

18559500

HgeneSRPK2

GO:0008380

RNA splicing

9472028

HgeneSRPK2

GO:0035556

intracellular signal transduction

9472028

HgeneSRPK2

GO:0045070

positive regulation of viral genome replication

20498328

HgeneSRPK2

GO:0045071

negative regulation of viral genome replication

12417631

TgenePRKAR2B

GO:2000480

negative regulation of cAMP-dependent protein kinase activity

21812984


check buttonFusion gene breakpoints across SRPK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PRKAR2B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRPTCGA-5P-A9JZ-01ASRPK2chr7

104800954

-PRKAR2Bchr7

106791367

+
ChimerDB4KIRPTCGA-5P-A9JZSRPK2chr7

104800953

-PRKAR2Bchr7

106791366

+
ChimerDB4KIRPTCGA-5P-A9JZSRPK2chr7

104800954

-PRKAR2Bchr7

106791367

+


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Fusion Gene ORF analysis for SRPK2-PRKAR2B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000357311ENST00000393613SRPK2chr7

104800954

-PRKAR2Bchr7

106791367

+
5CDS-intronENST00000357311ENST00000393613SRPK2chr7

104800953

-PRKAR2Bchr7

106791366

+
5CDS-intronENST00000393651ENST00000393613SRPK2chr7

104800954

-PRKAR2Bchr7

106791367

+
5CDS-intronENST00000393651ENST00000393613SRPK2chr7

104800953

-PRKAR2Bchr7

106791366

+
5CDS-intronENST00000489828ENST00000393613SRPK2chr7

104800954

-PRKAR2Bchr7

106791367

+
5CDS-intronENST00000489828ENST00000393613SRPK2chr7

104800953

-PRKAR2Bchr7

106791366

+
Frame-shiftENST00000489828ENST00000265717SRPK2chr7

104800954

-PRKAR2Bchr7

106791367

+
Frame-shiftENST00000489828ENST00000265717SRPK2chr7

104800953

-PRKAR2Bchr7

106791366

+
In-frameENST00000357311ENST00000265717SRPK2chr7

104800954

-PRKAR2Bchr7

106791367

+
In-frameENST00000357311ENST00000265717SRPK2chr7

104800953

-PRKAR2Bchr7

106791366

+
In-frameENST00000393651ENST00000265717SRPK2chr7

104800954

-PRKAR2Bchr7

106791367

+
In-frameENST00000393651ENST00000265717SRPK2chr7

104800953

-PRKAR2Bchr7

106791366

+
intron-3CDSENST00000493638ENST00000265717SRPK2chr7

104800954

-PRKAR2Bchr7

106791367

+
intron-3CDSENST00000493638ENST00000265717SRPK2chr7

104800953

-PRKAR2Bchr7

106791366

+
intron-intronENST00000493638ENST00000393613SRPK2chr7

104800954

-PRKAR2Bchr7

106791367

+
intron-intronENST00000493638ENST00000393613SRPK2chr7

104800953

-PRKAR2Bchr7

106791366

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393651SRPK2chr7104800954-ENST00000265717PRKAR2Bchr7106791367+3454709881224378
ENST00000357311SRPK2chr7104800954-ENST00000265717PRKAR2Bchr7106791367+3505760941275393
ENST00000393651SRPK2chr7104800953-ENST00000265717PRKAR2Bchr7106791366+3454709881224378
ENST00000357311SRPK2chr7104800953-ENST00000265717PRKAR2Bchr7106791366+3505760941275393

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393651ENST00000265717SRPK2chr7104800954-PRKAR2Bchr7106791367+0.00026050.99973947
ENST00000357311ENST00000265717SRPK2chr7104800954-PRKAR2Bchr7106791367+0.0002293390.9997707
ENST00000393651ENST00000265717SRPK2chr7104800953-PRKAR2Bchr7106791366+0.00026050.99973947
ENST00000357311ENST00000265717SRPK2chr7104800953-PRKAR2Bchr7106791366+0.0002293390.9997707

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Fusion Genomic Features for SRPK2-PRKAR2B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SRPK2chr7104800953-PRKAR2Bchr7106791366+3.99E-081
SRPK2chr7104800953-PRKAR2Bchr7106791366+3.99E-081
SRPK2chr7104800953-PRKAR2Bchr7106791366+3.99E-081
SRPK2chr7104800953-PRKAR2Bchr7106791366+3.99E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SRPK2-PRKAR2B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:104800954/chr7:106791367)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSRPK2chr7:104800953chr7:106791366ENST00000357311-61587_95196689.0Nucleotide bindingATP
HgeneSRPK2chr7:104800953chr7:106791366ENST00000393651-71687_95207700.0Nucleotide bindingATP
HgeneSRPK2chr7:104800953chr7:106791366ENST00000489828-81787_95196689.0Nucleotide bindingATP
HgeneSRPK2chr7:104800954chr7:106791367ENST00000357311-61587_95196689.0Nucleotide bindingATP
HgeneSRPK2chr7:104800954chr7:106791367ENST00000393651-71687_95207700.0Nucleotide bindingATP
HgeneSRPK2chr7:104800954chr7:106791367ENST00000489828-81787_95196689.0Nucleotide bindingATP
TgenePRKAR2Bchr7:104800953chr7:106791366ENST00000265717511276_418247419.0Nucleotide bindingNote=cAMP 2
TgenePRKAR2Bchr7:104800954chr7:106791367ENST00000265717511276_418247419.0Nucleotide bindingNote=cAMP 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSRPK2chr7:104800953chr7:106791366ENST00000357311-61581_684196689.0DomainProtein kinase
HgeneSRPK2chr7:104800953chr7:106791366ENST00000393651-71681_684207700.0DomainProtein kinase
HgeneSRPK2chr7:104800953chr7:106791366ENST00000489828-81781_684196689.0DomainProtein kinase
HgeneSRPK2chr7:104800954chr7:106791367ENST00000357311-61581_684196689.0DomainProtein kinase
HgeneSRPK2chr7:104800954chr7:106791367ENST00000393651-71681_684207700.0DomainProtein kinase
HgeneSRPK2chr7:104800954chr7:106791367ENST00000489828-81781_684196689.0DomainProtein kinase
TgenePRKAR2Bchr7:104800953chr7:106791366ENST00000265717511154_275247419.0Nucleotide bindingNote=cAMP 1
TgenePRKAR2Bchr7:104800954chr7:106791367ENST00000265717511154_275247419.0Nucleotide bindingNote=cAMP 1
TgenePRKAR2Bchr7:104800953chr7:106791366ENST000002657175112_153247419.0RegionNote=Dimerization and phosphorylation
TgenePRKAR2Bchr7:104800954chr7:106791367ENST000002657175112_153247419.0RegionNote=Dimerization and phosphorylation


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Fusion Gene Sequence for SRPK2-PRKAR2B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>86510_86510_1_SRPK2-PRKAR2B_SRPK2_chr7_104800953_ENST00000357311_PRKAR2B_chr7_106791366_ENST00000265717_length(transcript)=3505nt_BP=760nt
CCATTGAATCCCAGTCCTAACAGAAGTACTGCGAATCTTGTGGCCTCATTCTGAACAAAAGGGATTAGAGAAGAAAAATCTCTTGATATA
AGGCTTGAAAGCAAGGGCAGGCAATCTTGGTTGTGAATATTTTCTGATTTTTCCAGAAATCAAGCAGAAGATTGAGCTGCTGATGTCAGT
TAACTCTGAGAAGTCGTCCTCTTCAGAAAGGCCGGAGCCTCAACAGAAAGCTCCTTTAGTTCCTCCTCCTCCACCGCCACCACCACCACC
ACCGCCACCTTTGCCAGACCCCACACCCCCGGAGCCAGAGGAGGAGATCCTGGGATCAGATGATGAGGAGCAAGAGGACCCTGCGGACTA
CTGCAAAGGTGGATATCATCCAGTGAAAATTGGAGACCTCTTCAATGGCCGGTATCATGTTATTAGAAAGCTTGGATGGGGGCACTTCTC
TACTGTCTGGCTGTGCTGGGATATGCAGGGGAAAAGATTTGTTGCAATGAAAGTTGTAAAAAGTGCCCAGCATTATACGGAGACAGCCTT
GGATGAAATAAAATTGCTCAAATGTGTTCGAGAAAGTGATCCCAGTGACCCAAACAAAGACATGGTGGTCCAGCTCATTGACGACTTCAA
GATTTCAGGCATGAATGGGATACATGTCTGCATGGTCTTCGAAGTACTTGGCCACCATCTCCTCAAGTGGATCATCAAATCCAACTATCA
AGGCCTCCCAGTACGTTGTGTGAAGAGTATCATTCGACAGGACAGGGTAACCTTCAGGAGAATAATTGTGAAAAACAATGCCAAAAAGAG
AAAAATGTATGAAAGCTTTATTGAGTCACTGCCATTCCTTAAATCTTTGGAGTTTTCTGAACGCCTGAAAGTAGTAGATGTGATAGGCAC
CAAAGTATACAACGATGGAGAACAAATCATTGCTCAGGGAGATTCGGCTGATTCTTTTTTCATTGTAGAATCTGGAGAAGTGAAAATTAC
TATGAAAAGAAAGGGTAAATCAGAAGTGGAAGAGAATGGTGCAGTAGAAATCGCTCGATGCTCGCGGGGACAGTACTTTGGAGAGCTTGC
CCTGGTAACTAACAAACCTCGAGCAGCTTCTGCCCACGCCATTGGGACTGTCAAATGTTTAGCAATGGATGTGCAAGCATTTGAAAGGCT
TCTGGGACCTTGCATGGAAATTATGAAAAGGAACATCGCTACCTATGAAGAACAGTTAGTTGCCCTGTTTGGAACGAACATGGATATTGT
TGAACCCACTGCATGAAGCAAAAGTATGGAGCAAGACCTGTAGTGACAAAATTACACAGTAGTGGTTAGTCCACTGAGAATGTGTTTGTG
TAGATGCCAAGCATTTTCTGTGATTTCAGGTTTTTTCCTTTTTTTACATTTACAACGTATCAATAAACAGTAGTGATTTAATAGTCAATA
GGCTTTAACATCACTTTCTAAAGAGTAGTTCATAAAAAAATCAACATACTGATAAAATGACTTTGTACTCCACAAAATTATGACTGAAAG
GTTTATTAAAATGATTGTAATATATAGAAAGTATCTGTGTTTAAGAAGATAATTAAAGGATGTTATCATAGGCTATATGTGTTTTACTTA
TTCAGACTGATAATCATATTAGTGACTATCCCCATGTAAGAGGGCACTTGGCAATTAAACATGCTACACAGCATGGCATCACTTTTTTTT
ATAACTCATTAAACACAGTAAAATTTTAATCATTTTTGTTTTAAAGTTTTCTAGCTTGATAAGTTATGTGCTGGCCTTGGCCTATTGGTG
AAATGGTATAAAATATCATATGCAGTTTTAAAACTTTTTATATTTTTGCAATAAAGTACATTTTGACTTTGTTGGCATAATGTCAGTAAC
ATACATATTCCAGTGGTTTTATGGACAGGCAATTTAGTCATTATGATAATAAGGAAAACAGTGTTTTAGATGAGAGATCATTAATGCATT
TTTCCCTCATCAAGCATATATCTGCTTTTTTTTATTTTGCAATTCTCTGTATTCTATGTCTTTAAAAATTTGATCTTGACATTTAATGTC
ACAAAGTTTTGTTTTTTTAAAAAGTGATTTAAACTTAAGATCCGACATTTTTTGTATTCTTTAAGATTTTACACCTAAAAAATCTCTCCT
ATCCCAAAAATAATGTGGGATCCTTATCAGCATGCCCACAGTTTATTTCTTTGTTCTTCACTAGGCCTGCATAATACAGTCCTATGTAGA
CATCTGTTCCCTTGGGTTTCCGTTCTTTCTTAGGATGGTTGCCAACCCACAATCTCATTGATCAGCAGCCAATATGGGTTTGTTTGGTTT
TTTTAATTCTTAAAAACATCCTCTAGAGGAATAGAAACAAATTTTTATGAGCATAACCCTATATAAAGACAAAATGAATTTCTGACCTTA
CCATATATACCATTAGGCCTTGCCATTGCTTTAATGTAGACTCATAGTTGAAATTAGTGCAGAAAGAACTCAGATGTACTAGATTTTCAT
TGTTCATTGATATGCTCAGTATGCTGCCACATAAGATGAATTTAATTATATTCAACCAAAGCAATATACTCTTACATGATTTCTAGGCCC
CATGACCCAGTGTCTAGAGACATTAATTCTAACCAGTTGTTTGCTTTTAAATGAGTGATTTCATTTTGGGAAACAGGTTTCAAATGAATA
TATATACATGGGTAAAATTACTCTGTGCTAGTGTAGTCTTACTAGAGAATGTTTATGGTCCCACTTGTATATGAAAATGTGGTTAGAATG
TTAATTGGATAATGTATATATAAGAAGTTAAAGTATGTAAAGTATAACTTCAGCCACATTTTTAGAACACTGTTTAACATTTTTGCAAAA
CCTTCTTGTAGGAAAAGAGAGCTCTCTACATGAAGATGACTTGTTTTATATTTCAGATTTTATTTTAAAAGCCATGTCTGTTAAACAAGA
AAAAACACAAAAGAACTCCAGATTCCTGGTTCATCATTCTGTATTCTTACTCACTTTTTCAAGTTATCTATTTTGTTGCATAAACTAATT
GTTAACTATTCATGGAACAGCAAACGCCTGTTTAATAAAGAACTTTGACCAAGGCTATAAATGCCACGTACATTATTTTCAGTATTGTTG
GTTATATTTAAATTTTCCTTACAATAAAGCACACTTTTATAATAAAATACATGAATTATTGTTTTTCATACTTTTTTGCTTGTTTCTTTA
AAGTTTTCTGACGTGCATAATGCATAATTCATTGAAAAGCATGATAGCAATGTGGCATGTGGAAGCGAACCCCCAGGGCATAACATAGTA
AGAAAGTATGGTTCTGTATGGCAATAGGTTTTTAAAATTATTAGCTATTCATCATGTGTGGGAGAAATAATTGTGGTGTGTTGCAGATTT

>86510_86510_1_SRPK2-PRKAR2B_SRPK2_chr7_104800953_ENST00000357311_PRKAR2B_chr7_106791366_ENST00000265717_length(amino acids)=393AA_BP=222
MKARAGNLGCEYFLIFPEIKQKIELLMSVNSEKSSSSERPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDPADYC
KGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKI
SGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTK
VYNDGEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLL

--------------------------------------------------------------
>86510_86510_2_SRPK2-PRKAR2B_SRPK2_chr7_104800953_ENST00000393651_PRKAR2B_chr7_106791366_ENST00000265717_length(transcript)=3454nt_BP=709nt
GGCGGAGCGAGTGGAGGCTGCAGCCCAGCTCGTCTCGGCGCCCGCGTCGCCGTCGCGAAGCCCCCCGCCCCGCTTCCGCCGCGTCGGAAT
GAGCTCCCGGAAAGTGCTGGCCATTCAGGCCCGAAAGCGGAGGCCGAAAAGAGAGAAACATCCGAAAAAGCCGGAGCCTCAACAGAAAGC
TCCTTTAGTTCCTCCTCCTCCACCGCCACCACCACCACCACCGCCACCTTTGCCAGACCCCACACCCCCGGAGCCAGAGGAGGAGATCCT
GGGATCAGATGATGAGGAGCAAGAGGACCCTGCGGACTACTGCAAAGGTGGATATCATCCAGTGAAAATTGGAGACCTCTTCAATGGCCG
GTATCATGTTATTAGAAAGCTTGGATGGGGGCACTTCTCTACTGTCTGGCTGTGCTGGGATATGCAGGGGAAAAGATTTGTTGCAATGAA
AGTTGTAAAAAGTGCCCAGCATTATACGGAGACAGCCTTGGATGAAATAAAATTGCTCAAATGTGTTCGAGAAAGTGATCCCAGTGACCC
AAACAAAGACATGGTGGTCCAGCTCATTGACGACTTCAAGATTTCAGGCATGAATGGGATACATGTCTGCATGGTCTTCGAAGTACTTGG
CCACCATCTCCTCAAGTGGATCATCAAATCCAACTATCAAGGCCTCCCAGTACGTTGTGTGAAGAGTATCATTCGACAGGACAGGGTAAC
CTTCAGGAGAATAATTGTGAAAAACAATGCCAAAAAGAGAAAAATGTATGAAAGCTTTATTGAGTCACTGCCATTCCTTAAATCTTTGGA
GTTTTCTGAACGCCTGAAAGTAGTAGATGTGATAGGCACCAAAGTATACAACGATGGAGAACAAATCATTGCTCAGGGAGATTCGGCTGA
TTCTTTTTTCATTGTAGAATCTGGAGAAGTGAAAATTACTATGAAAAGAAAGGGTAAATCAGAAGTGGAAGAGAATGGTGCAGTAGAAAT
CGCTCGATGCTCGCGGGGACAGTACTTTGGAGAGCTTGCCCTGGTAACTAACAAACCTCGAGCAGCTTCTGCCCACGCCATTGGGACTGT
CAAATGTTTAGCAATGGATGTGCAAGCATTTGAAAGGCTTCTGGGACCTTGCATGGAAATTATGAAAAGGAACATCGCTACCTATGAAGA
ACAGTTAGTTGCCCTGTTTGGAACGAACATGGATATTGTTGAACCCACTGCATGAAGCAAAAGTATGGAGCAAGACCTGTAGTGACAAAA
TTACACAGTAGTGGTTAGTCCACTGAGAATGTGTTTGTGTAGATGCCAAGCATTTTCTGTGATTTCAGGTTTTTTCCTTTTTTTACATTT
ACAACGTATCAATAAACAGTAGTGATTTAATAGTCAATAGGCTTTAACATCACTTTCTAAAGAGTAGTTCATAAAAAAATCAACATACTG
ATAAAATGACTTTGTACTCCACAAAATTATGACTGAAAGGTTTATTAAAATGATTGTAATATATAGAAAGTATCTGTGTTTAAGAAGATA
ATTAAAGGATGTTATCATAGGCTATATGTGTTTTACTTATTCAGACTGATAATCATATTAGTGACTATCCCCATGTAAGAGGGCACTTGG
CAATTAAACATGCTACACAGCATGGCATCACTTTTTTTTATAACTCATTAAACACAGTAAAATTTTAATCATTTTTGTTTTAAAGTTTTC
TAGCTTGATAAGTTATGTGCTGGCCTTGGCCTATTGGTGAAATGGTATAAAATATCATATGCAGTTTTAAAACTTTTTATATTTTTGCAA
TAAAGTACATTTTGACTTTGTTGGCATAATGTCAGTAACATACATATTCCAGTGGTTTTATGGACAGGCAATTTAGTCATTATGATAATA
AGGAAAACAGTGTTTTAGATGAGAGATCATTAATGCATTTTTCCCTCATCAAGCATATATCTGCTTTTTTTTATTTTGCAATTCTCTGTA
TTCTATGTCTTTAAAAATTTGATCTTGACATTTAATGTCACAAAGTTTTGTTTTTTTAAAAAGTGATTTAAACTTAAGATCCGACATTTT
TTGTATTCTTTAAGATTTTACACCTAAAAAATCTCTCCTATCCCAAAAATAATGTGGGATCCTTATCAGCATGCCCACAGTTTATTTCTT
TGTTCTTCACTAGGCCTGCATAATACAGTCCTATGTAGACATCTGTTCCCTTGGGTTTCCGTTCTTTCTTAGGATGGTTGCCAACCCACA
ATCTCATTGATCAGCAGCCAATATGGGTTTGTTTGGTTTTTTTAATTCTTAAAAACATCCTCTAGAGGAATAGAAACAAATTTTTATGAG
CATAACCCTATATAAAGACAAAATGAATTTCTGACCTTACCATATATACCATTAGGCCTTGCCATTGCTTTAATGTAGACTCATAGTTGA
AATTAGTGCAGAAAGAACTCAGATGTACTAGATTTTCATTGTTCATTGATATGCTCAGTATGCTGCCACATAAGATGAATTTAATTATAT
TCAACCAAAGCAATATACTCTTACATGATTTCTAGGCCCCATGACCCAGTGTCTAGAGACATTAATTCTAACCAGTTGTTTGCTTTTAAA
TGAGTGATTTCATTTTGGGAAACAGGTTTCAAATGAATATATATACATGGGTAAAATTACTCTGTGCTAGTGTAGTCTTACTAGAGAATG
TTTATGGTCCCACTTGTATATGAAAATGTGGTTAGAATGTTAATTGGATAATGTATATATAAGAAGTTAAAGTATGTAAAGTATAACTTC
AGCCACATTTTTAGAACACTGTTTAACATTTTTGCAAAACCTTCTTGTAGGAAAAGAGAGCTCTCTACATGAAGATGACTTGTTTTATAT
TTCAGATTTTATTTTAAAAGCCATGTCTGTTAAACAAGAAAAAACACAAAAGAACTCCAGATTCCTGGTTCATCATTCTGTATTCTTACT
CACTTTTTCAAGTTATCTATTTTGTTGCATAAACTAATTGTTAACTATTCATGGAACAGCAAACGCCTGTTTAATAAAGAACTTTGACCA
AGGCTATAAATGCCACGTACATTATTTTCAGTATTGTTGGTTATATTTAAATTTTCCTTACAATAAAGCACACTTTTATAATAAAATACA
TGAATTATTGTTTTTCATACTTTTTTGCTTGTTTCTTTAAAGTTTTCTGACGTGCATAATGCATAATTCATTGAAAAGCATGATAGCAAT
GTGGCATGTGGAAGCGAACCCCCAGGGCATAACATAGTAAGAAAGTATGGTTCTGTATGGCAATAGGTTTTTAAAATTATTAGCTATTCA
TCATGTGTGGGAGAAATAATTGTGGTGTGTTGCAGATTTATTTGGCCATTTAGAATAACCAAATCAATCTGGCTAACTAGGAATTTATGT

>86510_86510_2_SRPK2-PRKAR2B_SRPK2_chr7_104800953_ENST00000393651_PRKAR2B_chr7_106791366_ENST00000265717_length(amino acids)=378AA_BP=207
MSSRKVLAIQARKRRPKREKHPKKPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNG
RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVL
GHHLLKWIIKSNYQGLPVRCVKSIIRQDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSA
DSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYE

--------------------------------------------------------------
>86510_86510_3_SRPK2-PRKAR2B_SRPK2_chr7_104800954_ENST00000357311_PRKAR2B_chr7_106791367_ENST00000265717_length(transcript)=3505nt_BP=760nt
CCATTGAATCCCAGTCCTAACAGAAGTACTGCGAATCTTGTGGCCTCATTCTGAACAAAAGGGATTAGAGAAGAAAAATCTCTTGATATA
AGGCTTGAAAGCAAGGGCAGGCAATCTTGGTTGTGAATATTTTCTGATTTTTCCAGAAATCAAGCAGAAGATTGAGCTGCTGATGTCAGT
TAACTCTGAGAAGTCGTCCTCTTCAGAAAGGCCGGAGCCTCAACAGAAAGCTCCTTTAGTTCCTCCTCCTCCACCGCCACCACCACCACC
ACCGCCACCTTTGCCAGACCCCACACCCCCGGAGCCAGAGGAGGAGATCCTGGGATCAGATGATGAGGAGCAAGAGGACCCTGCGGACTA
CTGCAAAGGTGGATATCATCCAGTGAAAATTGGAGACCTCTTCAATGGCCGGTATCATGTTATTAGAAAGCTTGGATGGGGGCACTTCTC
TACTGTCTGGCTGTGCTGGGATATGCAGGGGAAAAGATTTGTTGCAATGAAAGTTGTAAAAAGTGCCCAGCATTATACGGAGACAGCCTT
GGATGAAATAAAATTGCTCAAATGTGTTCGAGAAAGTGATCCCAGTGACCCAAACAAAGACATGGTGGTCCAGCTCATTGACGACTTCAA
GATTTCAGGCATGAATGGGATACATGTCTGCATGGTCTTCGAAGTACTTGGCCACCATCTCCTCAAGTGGATCATCAAATCCAACTATCA
AGGCCTCCCAGTACGTTGTGTGAAGAGTATCATTCGACAGGACAGGGTAACCTTCAGGAGAATAATTGTGAAAAACAATGCCAAAAAGAG
AAAAATGTATGAAAGCTTTATTGAGTCACTGCCATTCCTTAAATCTTTGGAGTTTTCTGAACGCCTGAAAGTAGTAGATGTGATAGGCAC
CAAAGTATACAACGATGGAGAACAAATCATTGCTCAGGGAGATTCGGCTGATTCTTTTTTCATTGTAGAATCTGGAGAAGTGAAAATTAC
TATGAAAAGAAAGGGTAAATCAGAAGTGGAAGAGAATGGTGCAGTAGAAATCGCTCGATGCTCGCGGGGACAGTACTTTGGAGAGCTTGC
CCTGGTAACTAACAAACCTCGAGCAGCTTCTGCCCACGCCATTGGGACTGTCAAATGTTTAGCAATGGATGTGCAAGCATTTGAAAGGCT
TCTGGGACCTTGCATGGAAATTATGAAAAGGAACATCGCTACCTATGAAGAACAGTTAGTTGCCCTGTTTGGAACGAACATGGATATTGT
TGAACCCACTGCATGAAGCAAAAGTATGGAGCAAGACCTGTAGTGACAAAATTACACAGTAGTGGTTAGTCCACTGAGAATGTGTTTGTG
TAGATGCCAAGCATTTTCTGTGATTTCAGGTTTTTTCCTTTTTTTACATTTACAACGTATCAATAAACAGTAGTGATTTAATAGTCAATA
GGCTTTAACATCACTTTCTAAAGAGTAGTTCATAAAAAAATCAACATACTGATAAAATGACTTTGTACTCCACAAAATTATGACTGAAAG
GTTTATTAAAATGATTGTAATATATAGAAAGTATCTGTGTTTAAGAAGATAATTAAAGGATGTTATCATAGGCTATATGTGTTTTACTTA
TTCAGACTGATAATCATATTAGTGACTATCCCCATGTAAGAGGGCACTTGGCAATTAAACATGCTACACAGCATGGCATCACTTTTTTTT
ATAACTCATTAAACACAGTAAAATTTTAATCATTTTTGTTTTAAAGTTTTCTAGCTTGATAAGTTATGTGCTGGCCTTGGCCTATTGGTG
AAATGGTATAAAATATCATATGCAGTTTTAAAACTTTTTATATTTTTGCAATAAAGTACATTTTGACTTTGTTGGCATAATGTCAGTAAC
ATACATATTCCAGTGGTTTTATGGACAGGCAATTTAGTCATTATGATAATAAGGAAAACAGTGTTTTAGATGAGAGATCATTAATGCATT
TTTCCCTCATCAAGCATATATCTGCTTTTTTTTATTTTGCAATTCTCTGTATTCTATGTCTTTAAAAATTTGATCTTGACATTTAATGTC
ACAAAGTTTTGTTTTTTTAAAAAGTGATTTAAACTTAAGATCCGACATTTTTTGTATTCTTTAAGATTTTACACCTAAAAAATCTCTCCT
ATCCCAAAAATAATGTGGGATCCTTATCAGCATGCCCACAGTTTATTTCTTTGTTCTTCACTAGGCCTGCATAATACAGTCCTATGTAGA
CATCTGTTCCCTTGGGTTTCCGTTCTTTCTTAGGATGGTTGCCAACCCACAATCTCATTGATCAGCAGCCAATATGGGTTTGTTTGGTTT
TTTTAATTCTTAAAAACATCCTCTAGAGGAATAGAAACAAATTTTTATGAGCATAACCCTATATAAAGACAAAATGAATTTCTGACCTTA
CCATATATACCATTAGGCCTTGCCATTGCTTTAATGTAGACTCATAGTTGAAATTAGTGCAGAAAGAACTCAGATGTACTAGATTTTCAT
TGTTCATTGATATGCTCAGTATGCTGCCACATAAGATGAATTTAATTATATTCAACCAAAGCAATATACTCTTACATGATTTCTAGGCCC
CATGACCCAGTGTCTAGAGACATTAATTCTAACCAGTTGTTTGCTTTTAAATGAGTGATTTCATTTTGGGAAACAGGTTTCAAATGAATA
TATATACATGGGTAAAATTACTCTGTGCTAGTGTAGTCTTACTAGAGAATGTTTATGGTCCCACTTGTATATGAAAATGTGGTTAGAATG
TTAATTGGATAATGTATATATAAGAAGTTAAAGTATGTAAAGTATAACTTCAGCCACATTTTTAGAACACTGTTTAACATTTTTGCAAAA
CCTTCTTGTAGGAAAAGAGAGCTCTCTACATGAAGATGACTTGTTTTATATTTCAGATTTTATTTTAAAAGCCATGTCTGTTAAACAAGA
AAAAACACAAAAGAACTCCAGATTCCTGGTTCATCATTCTGTATTCTTACTCACTTTTTCAAGTTATCTATTTTGTTGCATAAACTAATT
GTTAACTATTCATGGAACAGCAAACGCCTGTTTAATAAAGAACTTTGACCAAGGCTATAAATGCCACGTACATTATTTTCAGTATTGTTG
GTTATATTTAAATTTTCCTTACAATAAAGCACACTTTTATAATAAAATACATGAATTATTGTTTTTCATACTTTTTTGCTTGTTTCTTTA
AAGTTTTCTGACGTGCATAATGCATAATTCATTGAAAAGCATGATAGCAATGTGGCATGTGGAAGCGAACCCCCAGGGCATAACATAGTA
AGAAAGTATGGTTCTGTATGGCAATAGGTTTTTAAAATTATTAGCTATTCATCATGTGTGGGAGAAATAATTGTGGTGTGTTGCAGATTT

>86510_86510_3_SRPK2-PRKAR2B_SRPK2_chr7_104800954_ENST00000357311_PRKAR2B_chr7_106791367_ENST00000265717_length(amino acids)=393AA_BP=222
MKARAGNLGCEYFLIFPEIKQKIELLMSVNSEKSSSSERPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDPADYC
KGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKI
SGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTK
VYNDGEQIIAQGDSADSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLL

--------------------------------------------------------------
>86510_86510_4_SRPK2-PRKAR2B_SRPK2_chr7_104800954_ENST00000393651_PRKAR2B_chr7_106791367_ENST00000265717_length(transcript)=3454nt_BP=709nt
GGCGGAGCGAGTGGAGGCTGCAGCCCAGCTCGTCTCGGCGCCCGCGTCGCCGTCGCGAAGCCCCCCGCCCCGCTTCCGCCGCGTCGGAAT
GAGCTCCCGGAAAGTGCTGGCCATTCAGGCCCGAAAGCGGAGGCCGAAAAGAGAGAAACATCCGAAAAAGCCGGAGCCTCAACAGAAAGC
TCCTTTAGTTCCTCCTCCTCCACCGCCACCACCACCACCACCGCCACCTTTGCCAGACCCCACACCCCCGGAGCCAGAGGAGGAGATCCT
GGGATCAGATGATGAGGAGCAAGAGGACCCTGCGGACTACTGCAAAGGTGGATATCATCCAGTGAAAATTGGAGACCTCTTCAATGGCCG
GTATCATGTTATTAGAAAGCTTGGATGGGGGCACTTCTCTACTGTCTGGCTGTGCTGGGATATGCAGGGGAAAAGATTTGTTGCAATGAA
AGTTGTAAAAAGTGCCCAGCATTATACGGAGACAGCCTTGGATGAAATAAAATTGCTCAAATGTGTTCGAGAAAGTGATCCCAGTGACCC
AAACAAAGACATGGTGGTCCAGCTCATTGACGACTTCAAGATTTCAGGCATGAATGGGATACATGTCTGCATGGTCTTCGAAGTACTTGG
CCACCATCTCCTCAAGTGGATCATCAAATCCAACTATCAAGGCCTCCCAGTACGTTGTGTGAAGAGTATCATTCGACAGGACAGGGTAAC
CTTCAGGAGAATAATTGTGAAAAACAATGCCAAAAAGAGAAAAATGTATGAAAGCTTTATTGAGTCACTGCCATTCCTTAAATCTTTGGA
GTTTTCTGAACGCCTGAAAGTAGTAGATGTGATAGGCACCAAAGTATACAACGATGGAGAACAAATCATTGCTCAGGGAGATTCGGCTGA
TTCTTTTTTCATTGTAGAATCTGGAGAAGTGAAAATTACTATGAAAAGAAAGGGTAAATCAGAAGTGGAAGAGAATGGTGCAGTAGAAAT
CGCTCGATGCTCGCGGGGACAGTACTTTGGAGAGCTTGCCCTGGTAACTAACAAACCTCGAGCAGCTTCTGCCCACGCCATTGGGACTGT
CAAATGTTTAGCAATGGATGTGCAAGCATTTGAAAGGCTTCTGGGACCTTGCATGGAAATTATGAAAAGGAACATCGCTACCTATGAAGA
ACAGTTAGTTGCCCTGTTTGGAACGAACATGGATATTGTTGAACCCACTGCATGAAGCAAAAGTATGGAGCAAGACCTGTAGTGACAAAA
TTACACAGTAGTGGTTAGTCCACTGAGAATGTGTTTGTGTAGATGCCAAGCATTTTCTGTGATTTCAGGTTTTTTCCTTTTTTTACATTT
ACAACGTATCAATAAACAGTAGTGATTTAATAGTCAATAGGCTTTAACATCACTTTCTAAAGAGTAGTTCATAAAAAAATCAACATACTG
ATAAAATGACTTTGTACTCCACAAAATTATGACTGAAAGGTTTATTAAAATGATTGTAATATATAGAAAGTATCTGTGTTTAAGAAGATA
ATTAAAGGATGTTATCATAGGCTATATGTGTTTTACTTATTCAGACTGATAATCATATTAGTGACTATCCCCATGTAAGAGGGCACTTGG
CAATTAAACATGCTACACAGCATGGCATCACTTTTTTTTATAACTCATTAAACACAGTAAAATTTTAATCATTTTTGTTTTAAAGTTTTC
TAGCTTGATAAGTTATGTGCTGGCCTTGGCCTATTGGTGAAATGGTATAAAATATCATATGCAGTTTTAAAACTTTTTATATTTTTGCAA
TAAAGTACATTTTGACTTTGTTGGCATAATGTCAGTAACATACATATTCCAGTGGTTTTATGGACAGGCAATTTAGTCATTATGATAATA
AGGAAAACAGTGTTTTAGATGAGAGATCATTAATGCATTTTTCCCTCATCAAGCATATATCTGCTTTTTTTTATTTTGCAATTCTCTGTA
TTCTATGTCTTTAAAAATTTGATCTTGACATTTAATGTCACAAAGTTTTGTTTTTTTAAAAAGTGATTTAAACTTAAGATCCGACATTTT
TTGTATTCTTTAAGATTTTACACCTAAAAAATCTCTCCTATCCCAAAAATAATGTGGGATCCTTATCAGCATGCCCACAGTTTATTTCTT
TGTTCTTCACTAGGCCTGCATAATACAGTCCTATGTAGACATCTGTTCCCTTGGGTTTCCGTTCTTTCTTAGGATGGTTGCCAACCCACA
ATCTCATTGATCAGCAGCCAATATGGGTTTGTTTGGTTTTTTTAATTCTTAAAAACATCCTCTAGAGGAATAGAAACAAATTTTTATGAG
CATAACCCTATATAAAGACAAAATGAATTTCTGACCTTACCATATATACCATTAGGCCTTGCCATTGCTTTAATGTAGACTCATAGTTGA
AATTAGTGCAGAAAGAACTCAGATGTACTAGATTTTCATTGTTCATTGATATGCTCAGTATGCTGCCACATAAGATGAATTTAATTATAT
TCAACCAAAGCAATATACTCTTACATGATTTCTAGGCCCCATGACCCAGTGTCTAGAGACATTAATTCTAACCAGTTGTTTGCTTTTAAA
TGAGTGATTTCATTTTGGGAAACAGGTTTCAAATGAATATATATACATGGGTAAAATTACTCTGTGCTAGTGTAGTCTTACTAGAGAATG
TTTATGGTCCCACTTGTATATGAAAATGTGGTTAGAATGTTAATTGGATAATGTATATATAAGAAGTTAAAGTATGTAAAGTATAACTTC
AGCCACATTTTTAGAACACTGTTTAACATTTTTGCAAAACCTTCTTGTAGGAAAAGAGAGCTCTCTACATGAAGATGACTTGTTTTATAT
TTCAGATTTTATTTTAAAAGCCATGTCTGTTAAACAAGAAAAAACACAAAAGAACTCCAGATTCCTGGTTCATCATTCTGTATTCTTACT
CACTTTTTCAAGTTATCTATTTTGTTGCATAAACTAATTGTTAACTATTCATGGAACAGCAAACGCCTGTTTAATAAAGAACTTTGACCA
AGGCTATAAATGCCACGTACATTATTTTCAGTATTGTTGGTTATATTTAAATTTTCCTTACAATAAAGCACACTTTTATAATAAAATACA
TGAATTATTGTTTTTCATACTTTTTTGCTTGTTTCTTTAAAGTTTTCTGACGTGCATAATGCATAATTCATTGAAAAGCATGATAGCAAT
GTGGCATGTGGAAGCGAACCCCCAGGGCATAACATAGTAAGAAAGTATGGTTCTGTATGGCAATAGGTTTTTAAAATTATTAGCTATTCA
TCATGTGTGGGAGAAATAATTGTGGTGTGTTGCAGATTTATTTGGCCATTTAGAATAACCAAATCAATCTGGCTAACTAGGAATTTATGT

>86510_86510_4_SRPK2-PRKAR2B_SRPK2_chr7_104800954_ENST00000393651_PRKAR2B_chr7_106791367_ENST00000265717_length(amino acids)=378AA_BP=207
MSSRKVLAIQARKRRPKREKHPKKPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNG
RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVL
GHHLLKWIIKSNYQGLPVRCVKSIIRQDRVTFRRIIVKNNAKKRKMYESFIESLPFLKSLEFSERLKVVDVIGTKVYNDGEQIIAQGDSA
DSFFIVESGEVKITMKRKGKSEVEENGAVEIARCSRGQYFGELALVTNKPRAASAHAIGTVKCLAMDVQAFERLLGPCMEIMKRNIATYE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SRPK2-PRKAR2B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SRPK2-PRKAR2B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SRPK2-PRKAR2B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource