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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SRSF11-SYK (FusionGDB2 ID:86591)

Fusion Gene Summary for SRSF11-SYK

check button Fusion gene summary
Fusion gene informationFusion gene name: SRSF11-SYK
Fusion gene ID: 86591
HgeneTgene
Gene symbol

SRSF11

SYK

Gene ID

9295

6850

Gene nameserine and arginine rich splicing factor 11spleen associated tyrosine kinase
SynonymsNET2|SFRS11|dJ677H15.2|p54p72-Syk
Cytomap

1p31.1

9q22.2

Type of geneprotein-codingprotein-coding
Descriptionserine/arginine-rich splicing factor 11SR splicing factor 11arginine-rich 54 kDa nuclear proteinsplicing factor p54splicing factor, arginine/serine-rich 11tyrosine-protein kinase SYKspleen tyrosine kinase
Modification date2020031320200329
UniProtAcc.

P43405

Ensembl transtripts involved in fusion geneENST00000370950, ENST00000370951, 
ENST00000405432, ENST00000454435, 
ENST00000370949, ENST00000436161, 
ENST00000484162, 		ENST00000476708, 
ENST00000375746, ENST00000375747, 
ENST00000375751, ENST00000375754, 
Fusion gene scores* DoF score13 X 13 X 6=10149 X 9 X 6=486
# samples 169
** MAII scorelog2(16/1014*10)=-2.66391384211598
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/486*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SRSF11 [Title/Abstract] AND SYK [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSRSF11(70671463)-SYK(93606139), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSYK

GO:0006468

protein phosphorylation

17681949

TgeneSYK

GO:0007159

leukocyte cell-cell adhesion

12885943

TgeneSYK

GO:0030593

neutrophil chemotaxis

12885943


check buttonFusion gene breakpoints across SRSF11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across SYK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer135NSRSF11chr1

70671463

+SYKchr9

93606139

+


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Fusion Gene ORF analysis for SRSF11-SYK

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3UTRENST00000370950ENST00000476708SRSF11chr1

70671463

+SYKchr9

93606139

+
5UTR-3UTRENST00000370951ENST00000476708SRSF11chr1

70671463

+SYKchr9

93606139

+
5UTR-3UTRENST00000405432ENST00000476708SRSF11chr1

70671463

+SYKchr9

93606139

+
5UTR-3UTRENST00000454435ENST00000476708SRSF11chr1

70671463

+SYKchr9

93606139

+
5UTR-5UTRENST00000370950ENST00000375746SRSF11chr1

70671463

+SYKchr9

93606139

+
5UTR-5UTRENST00000370950ENST00000375747SRSF11chr1

70671463

+SYKchr9

93606139

+
5UTR-5UTRENST00000370950ENST00000375751SRSF11chr1

70671463

+SYKchr9

93606139

+
5UTR-5UTRENST00000370950ENST00000375754SRSF11chr1

70671463

+SYKchr9

93606139

+
5UTR-5UTRENST00000370951ENST00000375746SRSF11chr1

70671463

+SYKchr9

93606139

+
5UTR-5UTRENST00000370951ENST00000375747SRSF11chr1

70671463

+SYKchr9

93606139

+
5UTR-5UTRENST00000370951ENST00000375751SRSF11chr1

70671463

+SYKchr9

93606139

+
5UTR-5UTRENST00000370951ENST00000375754SRSF11chr1

70671463

+SYKchr9

93606139

+
5UTR-5UTRENST00000405432ENST00000375746SRSF11chr1

70671463

+SYKchr9

93606139

+
5UTR-5UTRENST00000405432ENST00000375747SRSF11chr1

70671463

+SYKchr9

93606139

+
5UTR-5UTRENST00000405432ENST00000375751SRSF11chr1

70671463

+SYKchr9

93606139

+
5UTR-5UTRENST00000405432ENST00000375754SRSF11chr1

70671463

+SYKchr9

93606139

+
5UTR-5UTRENST00000454435ENST00000375746SRSF11chr1

70671463

+SYKchr9

93606139

+
5UTR-5UTRENST00000454435ENST00000375747SRSF11chr1

70671463

+SYKchr9

93606139

+
5UTR-5UTRENST00000454435ENST00000375751SRSF11chr1

70671463

+SYKchr9

93606139

+
5UTR-5UTRENST00000454435ENST00000375754SRSF11chr1

70671463

+SYKchr9

93606139

+
intron-3UTRENST00000370949ENST00000476708SRSF11chr1

70671463

+SYKchr9

93606139

+
intron-3UTRENST00000436161ENST00000476708SRSF11chr1

70671463

+SYKchr9

93606139

+
intron-3UTRENST00000484162ENST00000476708SRSF11chr1

70671463

+SYKchr9

93606139

+
intron-5UTRENST00000370949ENST00000375746SRSF11chr1

70671463

+SYKchr9

93606139

+
intron-5UTRENST00000370949ENST00000375747SRSF11chr1

70671463

+SYKchr9

93606139

+
intron-5UTRENST00000370949ENST00000375751SRSF11chr1

70671463

+SYKchr9

93606139

+
intron-5UTRENST00000370949ENST00000375754SRSF11chr1

70671463

+SYKchr9

93606139

+
intron-5UTRENST00000436161ENST00000375746SRSF11chr1

70671463

+SYKchr9

93606139

+
intron-5UTRENST00000436161ENST00000375747SRSF11chr1

70671463

+SYKchr9

93606139

+
intron-5UTRENST00000436161ENST00000375751SRSF11chr1

70671463

+SYKchr9

93606139

+
intron-5UTRENST00000436161ENST00000375754SRSF11chr1

70671463

+SYKchr9

93606139

+
intron-5UTRENST00000484162ENST00000375746SRSF11chr1

70671463

+SYKchr9

93606139

+
intron-5UTRENST00000484162ENST00000375747SRSF11chr1

70671463

+SYKchr9

93606139

+
intron-5UTRENST00000484162ENST00000375751SRSF11chr1

70671463

+SYKchr9

93606139

+
intron-5UTRENST00000484162ENST00000375754SRSF11chr1

70671463

+SYKchr9

93606139

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SRSF11-SYK


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SRSF11chr170671463+SYKchr993606139+2.76E-101
SRSF11chr170671463+SYKchr993606139+2.76E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SRSF11-SYK


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:70671463/:93606139)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.SYK

P43405

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR plays also a role in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). Required for the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Plays also a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). {ECO:0000250|UniProtKB:P48025, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:12456653, ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:15388330, ECO:0000269|PubMed:19909739, ECO:0000269|PubMed:8657103, ECO:0000269|PubMed:9535867}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SRSF11-SYK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SRSF11-SYK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SRSF11-SYK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SRSF11-SYK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource