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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SRSF4-CREB5 (FusionGDB2 ID:86619)

Fusion Gene Summary for SRSF4-CREB5

check button Fusion gene summary
Fusion gene informationFusion gene name: SRSF4-CREB5
Fusion gene ID: 86619
HgeneTgene
Gene symbol

SRSF4

CREB5

Gene ID

6429

9586

Gene nameserine and arginine rich splicing factor 4cAMP responsive element binding protein 5
SynonymsSFRS4|SRP75CRE-BPA|CREB-5|CREBPA
Cytomap

1p35.3

7p15.1

Type of geneprotein-codingprotein-coding
Descriptionserine/arginine-rich splicing factor 4SR splicing factor 4SRP001LBpre-mRNA-splicing factor SRP75splicing factor, arginine/serine-rich 4cyclic AMP-responsive element-binding protein 5cAMP response element-binding protein CRE-BPacAMP-response element-binding protein A
Modification date2020031320200313
UniProtAcc.

Q02930

Ensembl transtripts involved in fusion geneENST00000373795, ENST00000546138, 
ENST00000466448, 		ENST00000482692, 
ENST00000357727, ENST00000396298, 
ENST00000396299, ENST00000396300, 
ENST00000409603, 
Fusion gene scores* DoF score7 X 5 X 6=21014 X 12 X 8=1344
# samples 815
** MAII scorelog2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1344*10)=-3.16349873228288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SRSF4 [Title/Abstract] AND CREB5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSRSF4(29508158)-CREB5(28843816), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSRSF4

GO:0048025

negative regulation of mRNA splicing, via spliceosome

15009664

TgeneCREB5

GO:0045893

positive regulation of transcription, DNA-templated

8378084


check buttonFusion gene breakpoints across SRSF4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CREB5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-FJ-A3Z7-01ASRSF4chr1

29508158

-CREB5chr7

28843816

+


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Fusion Gene ORF analysis for SRSF4-CREB5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000373795ENST00000482692SRSF4chr1

29508158

-CREB5chr7

28843816

+
5CDS-intronENST00000546138ENST00000482692SRSF4chr1

29508158

-CREB5chr7

28843816

+
5UTR-3CDSENST00000466448ENST00000357727SRSF4chr1

29508158

-CREB5chr7

28843816

+
5UTR-3CDSENST00000466448ENST00000396298SRSF4chr1

29508158

-CREB5chr7

28843816

+
5UTR-3CDSENST00000466448ENST00000396299SRSF4chr1

29508158

-CREB5chr7

28843816

+
5UTR-3CDSENST00000466448ENST00000396300SRSF4chr1

29508158

-CREB5chr7

28843816

+
5UTR-3CDSENST00000466448ENST00000409603SRSF4chr1

29508158

-CREB5chr7

28843816

+
5UTR-intronENST00000466448ENST00000482692SRSF4chr1

29508158

-CREB5chr7

28843816

+
In-frameENST00000373795ENST00000357727SRSF4chr1

29508158

-CREB5chr7

28843816

+
In-frameENST00000373795ENST00000396298SRSF4chr1

29508158

-CREB5chr7

28843816

+
In-frameENST00000373795ENST00000396299SRSF4chr1

29508158

-CREB5chr7

28843816

+
In-frameENST00000373795ENST00000396300SRSF4chr1

29508158

-CREB5chr7

28843816

+
In-frameENST00000373795ENST00000409603SRSF4chr1

29508158

-CREB5chr7

28843816

+
In-frameENST00000546138ENST00000357727SRSF4chr1

29508158

-CREB5chr7

28843816

+
In-frameENST00000546138ENST00000396298SRSF4chr1

29508158

-CREB5chr7

28843816

+
In-frameENST00000546138ENST00000396299SRSF4chr1

29508158

-CREB5chr7

28843816

+
In-frameENST00000546138ENST00000396300SRSF4chr1

29508158

-CREB5chr7

28843816

+
In-frameENST00000546138ENST00000409603SRSF4chr1

29508158

-CREB5chr7

28843816

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373795SRSF4chr129508158-ENST00000396299CREB5chr728843816+18883428611287
ENST00000373795SRSF4chr129508158-ENST00000357727CREB5chr728843816+77823423451166273
ENST00000373795SRSF4chr129508158-ENST00000396300CREB5chr728843816+18883428611287
ENST00000373795SRSF4chr129508158-ENST00000409603CREB5chr728843816+15253428611287
ENST00000373795SRSF4chr129508158-ENST00000396298CREB5chr728843816+18883428611287
ENST00000546138SRSF4chr129508158-ENST00000396299CREB5chr728843816+17992532561077273
ENST00000546138SRSF4chr129508158-ENST00000357727CREB5chr728843816+76932532561077273
ENST00000546138SRSF4chr129508158-ENST00000396300CREB5chr728843816+17992532561077273
ENST00000546138SRSF4chr129508158-ENST00000409603CREB5chr728843816+14362532561077273
ENST00000546138SRSF4chr129508158-ENST00000396298CREB5chr728843816+17992532561077273

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373795ENST00000396299SRSF4chr129508158-CREB5chr728843816+0.1215694550.8784306
ENST00000373795ENST00000357727SRSF4chr129508158-CREB5chr728843816+0.177046840.8229531
ENST00000373795ENST00000396300SRSF4chr129508158-CREB5chr728843816+0.1215694550.8784306
ENST00000373795ENST00000409603SRSF4chr129508158-CREB5chr728843816+0.05480420.9451958
ENST00000373795ENST00000396298SRSF4chr129508158-CREB5chr728843816+0.1215694550.8784306
ENST00000546138ENST00000396299SRSF4chr129508158-CREB5chr728843816+0.082781590.9172184
ENST00000546138ENST00000357727SRSF4chr129508158-CREB5chr728843816+0.16938730.83061266
ENST00000546138ENST00000396300SRSF4chr129508158-CREB5chr728843816+0.082781590.9172184
ENST00000546138ENST00000409603SRSF4chr129508158-CREB5chr728843816+0.033071910.9669281
ENST00000546138ENST00000396298SRSF4chr129508158-CREB5chr728843816+0.082781590.9172184

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Fusion Genomic Features for SRSF4-CREB5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SRSF4chr129508157-CREB5chr728843815+1.26E-101
SRSF4chr129508157-CREB5chr728843815+1.26E-101

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SRSF4-CREB5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:29508158/chr7:28843816)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CREB5

Q02930

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Binds to the cAMP response element and activates transcription. {ECO:0000269|PubMed:8378084}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCREB5chr1:29508158chr7:28843816ENST00000357727611375_438234509.0DomainbZIP
TgeneCREB5chr1:29508158chr7:28843816ENST0000039629827375_43895370.0DomainbZIP
TgeneCREB5chr1:29508158chr7:28843816ENST00000396299510375_438201476.0DomainbZIP
TgeneCREB5chr1:29508158chr7:28843816ENST00000396300611375_438227502.0DomainbZIP
TgeneCREB5chr1:29508158chr7:28843816ENST00000409603510375_438201476.0DomainbZIP
TgeneCREB5chr1:29508158chr7:28843816ENST00000357727611377_397234509.0RegionBasic motif
TgeneCREB5chr1:29508158chr7:28843816ENST00000357727611403_431234509.0RegionLeucine-zipper
TgeneCREB5chr1:29508158chr7:28843816ENST0000039629827377_39795370.0RegionBasic motif
TgeneCREB5chr1:29508158chr7:28843816ENST0000039629827403_43195370.0RegionLeucine-zipper
TgeneCREB5chr1:29508158chr7:28843816ENST00000396299510377_397201476.0RegionBasic motif
TgeneCREB5chr1:29508158chr7:28843816ENST00000396299510403_431201476.0RegionLeucine-zipper
TgeneCREB5chr1:29508158chr7:28843816ENST00000396300611377_397227502.0RegionBasic motif
TgeneCREB5chr1:29508158chr7:28843816ENST00000396300611403_431227502.0RegionLeucine-zipper
TgeneCREB5chr1:29508158chr7:28843816ENST00000409603510377_397201476.0RegionBasic motif
TgeneCREB5chr1:29508158chr7:28843816ENST00000409603510403_431201476.0RegionLeucine-zipper

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSRSF4chr1:29508158chr7:28843816ENST00000373795-16179_49435495.0Compositional biasNote=Arg/Ser-rich (RS domain)
HgeneSRSF4chr1:29508158chr7:28843816ENST00000373795-1672_9735495.0Compositional biasNote=Gly-rich (hinge region)
HgeneSRSF4chr1:29508158chr7:28843816ENST00000373795-16104_17735495.0DomainRRM 2
HgeneSRSF4chr1:29508158chr7:28843816ENST00000373795-162_7235495.0DomainRRM 1
TgeneCREB5chr1:29508158chr7:28843816ENST0000035772761116_40234509.0Zinc fingerC2H2-type
TgeneCREB5chr1:29508158chr7:28843816ENST000003962982716_4095370.0Zinc fingerC2H2-type
TgeneCREB5chr1:29508158chr7:28843816ENST0000039629951016_40201476.0Zinc fingerC2H2-type
TgeneCREB5chr1:29508158chr7:28843816ENST0000039630061116_40227502.0Zinc fingerC2H2-type
TgeneCREB5chr1:29508158chr7:28843816ENST0000040960351016_40201476.0Zinc fingerC2H2-type


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Fusion Gene Sequence for SRSF4-CREB5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>86619_86619_1_SRSF4-CREB5_SRSF4_chr1_29508158_ENST00000373795_CREB5_chr7_28843816_ENST00000357727_length(transcript)=7782nt_BP=342nt
GCCGAGCGGGAAGCGAACGCGCGCTCTCTCCGGTTACCTTCCGCCTCGGGGAAGGGCGGGGGAAGTGGAAGCGCGCGCTCGCGAGCTGCG
TGCTCGCGTACGTCGCCGGGGTTCGGCTGCGTCCGTCCCGCCGCCCGCCCGTTGCCGCCGCCGCCGCTGCCGCCGTGCTCTCGCTTTGCC
CGCCGCCGCCTAAGGGGGGCTGGGGCCGGGGCCAGCCATCACTGCCGTTGCCGGGATGCCGCGGGTGTACATCGGCCGCCTGAGCTACCA
GGCCCGGGAGCGCGATGTGGAGCGCTTCTTTAAGGGCTACGGGAAGATCCTGGAGGTGGATCTGAAGAACGGAGGTTGAAGGCTGCATTG
ACTCACCACCCTGCTGCCATGTCAAATGGGAACATGAACACCATGGGACACATGATGGAGATGATGGGCTCCCGGCAGGACCAGACGCCA
CACCATCACATGCACTCGCACCCGCATCAGCACCAGACACTGCCACCCCATCACCCTTACCCACACCAGCACCAGCACCCAGCACACCAT
CCTCACCCTCAACCCCATCACCAGCAGAACCATCCACATCACCACTCCCATTCCCACCTTCATGCACACCCAGCACATCACCAGACCTCG
CCACATCCGCCCCTGCACACCGGCAACCAAGCACAGGTTTCACCAGCAACACAACAGATGCAGCCAACCCAGACAATACAGCCACCCCAG
CCCACAGGGGGGCGCCGGCGAAGGGTGGTAGACGAGGATCCGGACGAGAGGCGGCGGAAATTTCTGGAACGGAACCGGGCAGCTGCCACC
CGCTGCAGACAGAAGAGGAAGGTCTGGGTGATGTCATTGGAAAAGAAAGCAGAAGAACTCACCCAGACAAACATGCAGCTTCAGAATGAA
GTGTCTATGTTGAAAAATGAGGTGGCCCAGCTGAAACAGTTGTTGTTAACACATAAAGACTGCCCAATAACAGCCATGCAGAAAGAATCA
CAAGGATATCTAAGTCCAGAGAGTAGCCCTCCTGCTAGTCCTGTCCCAGCTTGCTCCCAGCAACAAGTCATCCAGCATAATACCATCACT
ACTTCCTCATCGGTCAGCGAGGTGGTAGGAAGCTCCACCCTCAGCCAGCTCACCACTCACAGAACAGACCTGAATCCGATTCTTTAAAAT
GCACCATCAGACCTGGCCTCCAAGAAGAGCTGTAGCGTACCATGCGTCCTTTCTTTTAAGGGCATTTTTAGAATTAACTCAGACCTGGAA
GACTCCTCAGTTCTTCAAAGACTGGCTTTCATTTTTATAGTTATTATGGAAATGTTGTCTTTTATACTTAGTTATATAAGAAAAAAGGGA
GTTATGCAATTAATATCTATCAGCTTGGGAAACGCTTTGGTGCTTTTCTCCAGTTTTCTGGTACCAGTTACTTGTTTATAAACTGAACCT
TTTCTGTATATAGCCATGGTTTCATTCTTATCAGTCCAACCCTTTGCCTGAAACATTGAATCTTGTTAAACCACAGCTTTTAGCTAAAAT
GAGGTATACCTAGATGTCAAGTAAGACAGATCCAAGGTAACTGGGTAGGAAATCTTTTGACATCTTAACTCATGTTGAGTTTGTGCTGTG
GTGTCACCAGAATTCCAGATAAACACACAGCCTTTCCCATACCTTTTTTTTTCTTACTATAAAATATTATAAGATCCATTGATGTCCAAA
TAATACCACCAAGCATCTCTTCACCTCTCCTCCTCTTGGTCCACTTGCTAATGCCCAGTTTTCTTCTCCATTTCCACTTTTTCTTAGGCT
CCCTATTTACTATTCATTTTGACTTCCTTCTGTTTTATTTTTTTCCCTTTAGCATTGCATGTGAATAAGAAAATAATGTTTAAAGAAAAA
AAAAAAAAAGCAAACCTCCAAAACGTGGACCTAACCATTGCTTCACTTACACTTCACCCACAGCTGGAGTTCATTCAACTCTTGCTTTTC
ACAAAATAGTAACCAGGAGATGTTTAATGTGCCTGATTTAATGTTTTTAATAATCACAGCAAATGAAAGGTGGTTTAGTTATAAGTGAAG
CATGGTTGAATACCAGCTGGGGAGACACTAGGGAAGGGAGCTTTGTAAGCCTTGATTGCGAAAGTCCAAATTTTGATGTGGGGCTATAAC
ATGACACCCTTGGATTGCGACTGGTTTTATACGGCCTGCCTATAACGTTGAAAATCCATGTACTACATAATAATTCAGAAGGGCTCTATT
CACTACACAGATTACATTGTTCAATCATCAGCTGCTAATAGCCTAAGATTTATTTTTTTTTTTTTCTTAAGCCTATGGAACCGGCTTTGC
TGTTCTGGGGGGTGAAAATAGACTAACTACTGGAGAAACAAAGAGAGAAAGAAAACCCAGTGTTTCCATAGGGGCACTTTTAGCCTTCCC
ACAACAGTTAAGCACTCTTTGACTGCTGAAGGAACCCCATGGATGAGGTGCAGGCTACTTCACTCTTTTTTTTTCTTTTTTGAGACAGAG
TCTCACCTATTGCCCAGACTGAAGTGCAGTGGTGCGATCATGGATCACTGCAGCAGCATCCTCCGAGTTCAAGCTATCCTTCCACCTCCG
CCTCCTGAGTAGCTGGGACCACAGGTTCACATAACCATGCCTGGCTAATTTATTTTTACTTTTATTTTAAAATAAAAGATGAGGTCTGTC
TTATGTTGCCCAGGCTGGTCTCAAACTATCCTACTTCTTCCTCCCAAAGTGTTGGGATTATAGGTGTGAGCCACTGCACCCAGCCTACTT
CACTCTTCTGAATTATTCTGATTTATTTTCAACAACTTTTGTGAACTTGCCCGTGATACAAAGCAGATAGTCCCTGAACCACAGTCGTGC
CTCCTTGAAACAAGCCATTCTACTGTGCTAATGTTTTAATATCACATCTCACAAATAACAGGGGTGAATGTTTCTCTCTAGCAATCTAGG
CAGGTGCTGGTGTTTCATCTCCATTTGAATGCTTGACCTCTTAATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTCATGGGTTTTAA
AAGAACAGTATTTTACAAAAGGTGTAGCTTTTATAAGAGTGCAGAAAAGGGAAGGATGTGTTTTTTTCTCTCACTATAGTATAAGAATCT
ATTTTGGAGAAAAAAAGAAAATATGAGGGTCTCGAAGCATGATTTTTATATAACTAGTTTCAGTTTTATCTAATAACTTACTTTTTAAAT
CAATATTTATCAACAATCTTTCCTTGTATGCAGTGCTTTCAAAAGATGGTTTTGAGTGTCCAGTGAAACTTATGACTTGGATATATGGTT
GAAGAATCAAAACAAAAGCAAAAAAAAAAAGCAAAAAAAGAAAAGAGAAAAAAAGAAAAAATGCAAATGGAATAATTTTCTATTATATTT
TAGACAAACATATCATTTTCGAGTATTTTAAATACTGAATTCATAGTTGTTGTTTTTTAAATTCCAACAGTAACAGCTGAATGGTTTAAT
CTGACTGGCTTCCTAAGAAATGTTTAAGACTCAGCTTTAAAAAGAAGTTAACATTCATATCTCTGTTTTGAAATCAAAAATCATATTTCA
AAATTCTTTCCTAGGACCATCTATGTGTCTCCCCTCCCCTCCACAAAAAGGAGAAAGAGTGCATTAAAATGTTTAGTTGGGTTTTTTAAT
TTTTAATTTTTATGTTATGTTTTGCTTTGTTTTAAGTAAACAAAAATTTTTCTTTCTTTACTGCATGCATAGCACTTAATAAAATGGATT
TTTAAAAAATCCACTAGTAATATCAGAATGTCCAGGGAGTGACTGTCACTACAATGATGGTTTAGTTTACTTCTGTTCCACCTTTTGATT
GAAATATTTAGTTGTTAGGCTGAAAGCCTCGGCAGTTAAGAACTTGCCTGAGTTTTCTTCGTTCAGCAACTTGACAGTTTGACTGATGTG
CATTATATATAGCTCAATTATGTCTGTTTTTTATGCTAAGTAGGAAAACCAACCACACACATTAGCAAACCGGCCTCAACATATAATTAG
AATAAACTGTCTTCTTGTTCTACTCAGGGCCTTTAGGTGTGTTCATTCACGGTATGGAAATACAGTAAATGAAAGATTCCAACTAGTTGT
CAGTGCTTCTTGAAATTCCAAACAGAAAGATACATTGGTCAAATCCAACACTTGGCTTATCAATATTAAGTCTTTTACCTAAAGGCCCAG
CCGTCACCAGACAACAGAATAATCAATCTGCCTGAAAATCCCTCCTCCTTGTCCTACACTTTTTGCCTGTTTGGGAGAATATCTTTGTAC
TCCATTCTCCTCCCTCAGCCAGTTACTGGGTCACCCATCCATGTGTTCATGAATCAATCATCACGGCCTGCAGAGCACCTGTCCTAAGGA
GGGAAAATCCTGTCACACTGCCTCTCCCCATTCGTGTGTGGTTTTCTTGATCGGTGAGATCTGTCTCTGAAGTCACTGCCAGCCTCCCTG
GGAACGTCTATAGTGCCTCCCCTGCCTTATGTGATGGGAGTTAACAACTCAGATAAGTACACCTGAGAGCATTTCTATCAGGTAAACTGT
CACTTAAATGGAGGTGTCCACATCTTAATTGTTTCTCCTTGACACATTTCTCAATCCACGAAGCCAGGAGAGGTAGAGTGAAAATCCCAG
CCATGGATGAATGTACTAATTTGAAAGCCAAGTGTTAAGTCGGATGTTTTCCCGTTACACTACTACTCAGCCCTCTCCTGCGGCCACATC
AACGGATGCAAGTCACAGTCTTAACACAGCCTGTGGGAGACAAGCAGTTTGTGTGCTCACAGTATATATTATAGTAATTAGGGTGACTTA
GAGCAAATACTCTTCAGATCCTATGTAGTCAGTGAAACAAAATGGAGAGCGTATTCTGATAGAAGGACGTCGACGGTGAATGTTCTGGTG
GTTGTTGCCTGTTAAGTAAACTTTAGTGTGTAAGTTGAGTTTGTCATTAAAATCATAAACCAGCTGCGGTAACAGACAAGCCTTTGGCTG
GGGAGTTTTAAGCCTCGGTAACTGCTATAAAACTAGCCATCCAGTTAGGATAGAATGTGTTTCTTTCTGGTTAAAAAAAGGAAAAACCAT
CTAAGAAAATATATATGTATGTATGTGTGTATACAGTGGAATTCAAAGGACCAAAGCAAAATTTGAACAGGAATCTATTAATTTAGAATT
TTATAAGATATTTATTAATAAATGTTATTTTTAAACATTCCATTTGAACAGTATTCTGTAGGATCTACTTGTTTTTAAAGTGTTAGTCCA
TAATAAACTACTATAGTTATGTGTATTTTCATTTTTCAGGGTTTCAAATGGCTATTCTCCATCATTTGGTGGAAATGTTTGCTTAGATCT
CTGTGCATAGACATTTCAAGGATTTTTATTGCTCTGTGAGTTATTTTTTAATCAACATTCTGAACAGTTTTTTTTAAACATTTATTTCTG
TGTGTTCATTTTTAAAGTAAGCTCTTTCATTTAGGAAGCAGAGTTCAGCTAAAGGGAATCAGTAACTCTAACTGGAACAGCTTTCTTGTA
GAAGTGTAAAAACAGCTTCATCTCTGCCTCTCTCCACCCCACCCCAATTTCCTAGAAAGCCTTGCACTATTCAGCTCCCTTAGTGCTTTT
TGTCCCTTCCCGAACAATATGCAGTAGCTTTAAGCCATTCAAGCTCCATTATGCAGTATATCTGAGAAGGGAAAGGAAACAACCCATTTA
AATTTGAATAAAACCGTGCCTATGCGAACAGTAGCAATTTAGAATCTCTTTTCTGCTTTTAAAATAATTTATATTTAAAAATTGCACTTT
AGCTTTTTGATCCCTTTGTATTTCTCTTATTCTCTTTCTAACCTCTTCTCTGTCCTCAAACTTGCCTTTGCTCTCCTTTACAATACCCCC
CACCCCTCCTCCAAGGCTCTGAGCGGCATCATTTAAAATACTTTACAGATATTTGCACCAGGTACATTTATGTGCGTCCATTGGTAGCAC
AGCTGAGACCTGTGTCTCACATCAGCCTAGGTGAAGCCTACTACAAGAATGCCAAGGAGAAGAGCCAGTACACTATATGGTTTATACTCT
TTATCCCTTTATTCATAGCATGTTTTTTAAAAATGTTATATTATGCAACAGATGTGAGGCAGCAGCTAAGCTATACTTAAGAATTTTCTC
TCACCTTCCAAACCAAAGTGTCCTGAATAAGCCAGGAGACTTATTCTTTTGTGCACCCTGGTGCACATCTGACTGTTGTCCTAGCCATAG
ACTCTCTGAGGCCACTGAAAGAACAGTGGCCCTATCGATTTCATTCCTAGGTCTCAAAAATACAATGTTGCCTTGTAACATAATTAGGGA
CAGCACCTCTATTTCACAATTATAATCTAAGGTAGGATAAGACGACACAGCAGCAATAAACTTACAAGTAAAATTCAATACCAAAACAAA
CACAAAGAAATTTAAAAAACAAAAAACCTAGCTCATCATGTTGTGAAAATGAAAAAGTGAATGTCCATTCAAAATATTTTACTATTTCTT
GTGGAGTTTTTCAGTGATGTAATGCTTGTAGCCAAATTGCTTAAAGAGTGTTTATATATTTTTTTCCTTATAAATTGTCTATTTTTTAAA
AAAGCTATTTAACCACAGCTGAAGTGGGGGGTAAGGCCAAATTGCCAACACTTGTTAAAAGATTAATACTCTTAAGTGGCACTCTGATAC
CTTTCCAACTTGTCATCAGAAAGGAATCAATAATTACCAACTGTTGTATTTAGACCAACTTACAATATCTAGCTCATTAGAAGCCAGGAT
CTAGAAAGCTCCTTCTAAGCCATTTAAGATATTCTTACATTGAGCTTCATATTATAGAACTTTATAGGATTGGATATTTTACAATAGAAT
AATTTAGCCTCAGGACTGAGAATGTGGAAGCTGAATAAATTAGCTTTAAATACATCATTAAAATCTTATGCACAATAAGCTCATTAGATT
CTAGTTTTCTCCTTTAGAATACCAATGCCACAGACACTACAGGAGATAATGAAAGGTATCAGTTGTGTTGAGTGGAGGGAGTTTAAGAGA
AAGGACCCTTCCCAACCAGCAGCCAGTAGAAAATACAACCTACTCACCTTTTTCCCTTCTAAGTTCTGCTAAATCACATCTGCCTCATAG
AGAAAGGAATGTTGCCTTTGAGAACTGTCTTGGAGAACAGATAAGCTTGAAATGTTCTCTCTAGAGAGGACATAGGGTTTGGGATCCTCT
GAAAAGGCCCAGAAAAATAGCTCAGTTCAAATACAATGTTCTAGGACAATTGGAATATAAATATTGTCCAAAAATATAATTAAAAGAAAA
AAGTTTAGCACTGTGTAAAGTAAGTGTTAACTGAGGAAGTCCCAAAAAGGTGCTGTCACTTTAAGTTCTGGACTTGGGGTTCTTTGTATT
TGTAAACAGCAAAGCATTTGTGTTTGTTTGTCTATTTGTAAAGCAACCACCTTCCTTATTGGAAGGAGAAAAAAAGGGGTACATACATGT
AAATACTTGCTGCAGCATTTAATATGTTTAATTTTGTGTTAAGCTTTTTGTTGCATCGTGAACACATTTATTGTTACCAATGGACAATGA
GTTCATTAAGACTGTTCAACTAGGTCAGATTTTTACATCTCTTTCTAGCAAGAAGAGACAAGATTTTGTGCATTTGTACAAATGTTAATA

>86619_86619_1_SRSF4-CREB5_SRSF4_chr1_29508158_ENST00000373795_CREB5_chr7_28843816_ENST00000357727_length(amino acids)=273AA_BP=1
MKAALTHHPAAMSNGNMNTMGHMMEMMGSRQDQTPHHHMHSHPHQHQTLPPHHPYPHQHQHPAHHPHPQPHHQQNHPHHHSHSHLHAHPA
HHQTSPHPPLHTGNQAQVSPATQQMQPTQTIQPPQPTGGRRRRVVDEDPDERRRKFLERNRAAATRCRQKRKVWVMSLEKKAEELTQTNM
QLQNEVSMLKNEVAQLKQLLLTHKDCPITAMQKESQGYLSPESSPPASPVPACSQQQVIQHNTITTSSSVSEVVGSSTLSQLTTHRTDLN

--------------------------------------------------------------
>86619_86619_2_SRSF4-CREB5_SRSF4_chr1_29508158_ENST00000373795_CREB5_chr7_28843816_ENST00000396298_length(transcript)=1888nt_BP=342nt
GCCGAGCGGGAAGCGAACGCGCGCTCTCTCCGGTTACCTTCCGCCTCGGGGAAGGGCGGGGGAAGTGGAAGCGCGCGCTCGCGAGCTGCG
TGCTCGCGTACGTCGCCGGGGTTCGGCTGCGTCCGTCCCGCCGCCCGCCCGTTGCCGCCGCCGCCGCTGCCGCCGTGCTCTCGCTTTGCC
CGCCGCCGCCTAAGGGGGGCTGGGGCCGGGGCCAGCCATCACTGCCGTTGCCGGGATGCCGCGGGTGTACATCGGCCGCCTGAGCTACCA
GGCCCGGGAGCGCGATGTGGAGCGCTTCTTTAAGGGCTACGGGAAGATCCTGGAGGTGGATCTGAAGAACGGAGGTTGAAGGCTGCATTG
ACTCACCACCCTGCTGCCATGTCAAATGGGAACATGAACACCATGGGACACATGATGGAGATGATGGGCTCCCGGCAGGACCAGACGCCA
CACCATCACATGCACTCGCACCCGCATCAGCACCAGACACTGCCACCCCATCACCCTTACCCACACCAGCACCAGCACCCAGCACACCAT
CCTCACCCTCAACCCCATCACCAGCAGAACCATCCACATCACCACTCCCATTCCCACCTTCATGCACACCCAGCACATCACCAGACCTCG
CCACATCCGCCCCTGCACACCGGCAACCAAGCACAGGTTTCACCAGCAACACAACAGATGCAGCCAACCCAGACAATACAGCCACCCCAG
CCCACAGGGGGGCGCCGGCGAAGGGTGGTAGACGAGGATCCGGACGAGAGGCGGCGGAAATTTCTGGAACGGAACCGGGCAGCTGCCACC
CGCTGCAGACAGAAGAGGAAGGTCTGGGTGATGTCATTGGAAAAGAAAGCAGAAGAACTCACCCAGACAAACATGCAGCTTCAGAATGAA
GTGTCTATGTTGAAAAATGAGGTGGCCCAGCTGAAACAGTTGTTGTTAACACATAAAGACTGCCCAATAACAGCCATGCAGAAAGAATCA
CAAGGATATCTAAGTCCAGAGAGTAGCCCTCCTGCTAGTCCTGTCCCAGCTTGCTCCCAGCAACAAGTCATCCAGCATAATACCATCACT
ACTTCCTCATCGGTCAGCGAGGTGGTAGGAAGCTCCACCCTCAGCCAGCTCACCACTCACAGAACAGACCTGAATCCGATTCTTTAAAAT
GCACCATCAGACCTGGCCTCCAAGAAGAGCTGTAGCGTACCATGCGTCCTTTCTTTTAAGGGCATTTTTAGAATTAACTCAGACCTGGAA
GACTCCTCAGTTCTTCAAAGACTGGCTTTCATTTTTATAGTTATTATGGAAATGTTGTCTTTTATACTTAGTTATATAAGAAAAAAGGGA
GTTATGCAATTAATATCTATCAGCTTGGGAAACGCTTTGGTGCTTTTCTCCAGTTTTCTGGTACCAGTTACTTGTTTATAAACTGAACCT
TTTCTGTATATAGCCATGGTTTCATTCTTATCAGTCCAACCCTTTGCCTGAAACATTGAATCTTGTTAAACCACAGCTTTTAGCTAAAAT
GAGGTATACCTAGATGTCAAGTAAGACAGATCCAAGGTAACTGGGTAGGAAATCTTTTGACATCTTAACTCATGTTGAGTTTGTGCTGTG
GTGTCACCAGAATTCCAGATAAACACACAGCCTTTCCCATACCTTTTTTTTTCTTACTATAAAATATTATAAGATCCATTGATGTCCAAA
TAATACCACCAAGCATCTCTTCACCTCTCCTCCTCTTGGTCCACTTGCTAATGCCCAGTTTTCTTCTCCATTTCCACTTTTTCTTAGGCT

>86619_86619_2_SRSF4-CREB5_SRSF4_chr1_29508158_ENST00000373795_CREB5_chr7_28843816_ENST00000396298_length(amino acids)=287AA_BP=1
MLSFPMTSPRPSSSVCSGWQLPGSVPEISAASRPDPRLPPFAGAPLWAGVAVLSGLAASVVLLVKPVLGCRCAGADVARSGDVLGVHEGG
NGSGDVDGSAGDGVEGEDGVLGAGAGVGKGDGVAVSGADAGASACDGVASGPAGSPSSPSCVPWCSCSHLTWQQGGESMQPSTSVLQIHL
QDLPVALKEALHIALPGLVAQAADVHPRHPGNGSDGWPRPQPPLGGGGQSESTAAAAAAATGGRRDGRSRTPATYASTQLASARFHFPRP

--------------------------------------------------------------
>86619_86619_3_SRSF4-CREB5_SRSF4_chr1_29508158_ENST00000373795_CREB5_chr7_28843816_ENST00000396299_length(transcript)=1888nt_BP=342nt
GCCGAGCGGGAAGCGAACGCGCGCTCTCTCCGGTTACCTTCCGCCTCGGGGAAGGGCGGGGGAAGTGGAAGCGCGCGCTCGCGAGCTGCG
TGCTCGCGTACGTCGCCGGGGTTCGGCTGCGTCCGTCCCGCCGCCCGCCCGTTGCCGCCGCCGCCGCTGCCGCCGTGCTCTCGCTTTGCC
CGCCGCCGCCTAAGGGGGGCTGGGGCCGGGGCCAGCCATCACTGCCGTTGCCGGGATGCCGCGGGTGTACATCGGCCGCCTGAGCTACCA
GGCCCGGGAGCGCGATGTGGAGCGCTTCTTTAAGGGCTACGGGAAGATCCTGGAGGTGGATCTGAAGAACGGAGGTTGAAGGCTGCATTG
ACTCACCACCCTGCTGCCATGTCAAATGGGAACATGAACACCATGGGACACATGATGGAGATGATGGGCTCCCGGCAGGACCAGACGCCA
CACCATCACATGCACTCGCACCCGCATCAGCACCAGACACTGCCACCCCATCACCCTTACCCACACCAGCACCAGCACCCAGCACACCAT
CCTCACCCTCAACCCCATCACCAGCAGAACCATCCACATCACCACTCCCATTCCCACCTTCATGCACACCCAGCACATCACCAGACCTCG
CCACATCCGCCCCTGCACACCGGCAACCAAGCACAGGTTTCACCAGCAACACAACAGATGCAGCCAACCCAGACAATACAGCCACCCCAG
CCCACAGGGGGGCGCCGGCGAAGGGTGGTAGACGAGGATCCGGACGAGAGGCGGCGGAAATTTCTGGAACGGAACCGGGCAGCTGCCACC
CGCTGCAGACAGAAGAGGAAGGTCTGGGTGATGTCATTGGAAAAGAAAGCAGAAGAACTCACCCAGACAAACATGCAGCTTCAGAATGAA
GTGTCTATGTTGAAAAATGAGGTGGCCCAGCTGAAACAGTTGTTGTTAACACATAAAGACTGCCCAATAACAGCCATGCAGAAAGAATCA
CAAGGATATCTAAGTCCAGAGAGTAGCCCTCCTGCTAGTCCTGTCCCAGCTTGCTCCCAGCAACAAGTCATCCAGCATAATACCATCACT
ACTTCCTCATCGGTCAGCGAGGTGGTAGGAAGCTCCACCCTCAGCCAGCTCACCACTCACAGAACAGACCTGAATCCGATTCTTTAAAAT
GCACCATCAGACCTGGCCTCCAAGAAGAGCTGTAGCGTACCATGCGTCCTTTCTTTTAAGGGCATTTTTAGAATTAACTCAGACCTGGAA
GACTCCTCAGTTCTTCAAAGACTGGCTTTCATTTTTATAGTTATTATGGAAATGTTGTCTTTTATACTTAGTTATATAAGAAAAAAGGGA
GTTATGCAATTAATATCTATCAGCTTGGGAAACGCTTTGGTGCTTTTCTCCAGTTTTCTGGTACCAGTTACTTGTTTATAAACTGAACCT
TTTCTGTATATAGCCATGGTTTCATTCTTATCAGTCCAACCCTTTGCCTGAAACATTGAATCTTGTTAAACCACAGCTTTTAGCTAAAAT
GAGGTATACCTAGATGTCAAGTAAGACAGATCCAAGGTAACTGGGTAGGAAATCTTTTGACATCTTAACTCATGTTGAGTTTGTGCTGTG
GTGTCACCAGAATTCCAGATAAACACACAGCCTTTCCCATACCTTTTTTTTTCTTACTATAAAATATTATAAGATCCATTGATGTCCAAA
TAATACCACCAAGCATCTCTTCACCTCTCCTCCTCTTGGTCCACTTGCTAATGCCCAGTTTTCTTCTCCATTTCCACTTTTTCTTAGGCT

>86619_86619_3_SRSF4-CREB5_SRSF4_chr1_29508158_ENST00000373795_CREB5_chr7_28843816_ENST00000396299_length(amino acids)=287AA_BP=1
MLSFPMTSPRPSSSVCSGWQLPGSVPEISAASRPDPRLPPFAGAPLWAGVAVLSGLAASVVLLVKPVLGCRCAGADVARSGDVLGVHEGG
NGSGDVDGSAGDGVEGEDGVLGAGAGVGKGDGVAVSGADAGASACDGVASGPAGSPSSPSCVPWCSCSHLTWQQGGESMQPSTSVLQIHL
QDLPVALKEALHIALPGLVAQAADVHPRHPGNGSDGWPRPQPPLGGGGQSESTAAAAAAATGGRRDGRSRTPATYASTQLASARFHFPRP

--------------------------------------------------------------
>86619_86619_4_SRSF4-CREB5_SRSF4_chr1_29508158_ENST00000373795_CREB5_chr7_28843816_ENST00000396300_length(transcript)=1888nt_BP=342nt
GCCGAGCGGGAAGCGAACGCGCGCTCTCTCCGGTTACCTTCCGCCTCGGGGAAGGGCGGGGGAAGTGGAAGCGCGCGCTCGCGAGCTGCG
TGCTCGCGTACGTCGCCGGGGTTCGGCTGCGTCCGTCCCGCCGCCCGCCCGTTGCCGCCGCCGCCGCTGCCGCCGTGCTCTCGCTTTGCC
CGCCGCCGCCTAAGGGGGGCTGGGGCCGGGGCCAGCCATCACTGCCGTTGCCGGGATGCCGCGGGTGTACATCGGCCGCCTGAGCTACCA
GGCCCGGGAGCGCGATGTGGAGCGCTTCTTTAAGGGCTACGGGAAGATCCTGGAGGTGGATCTGAAGAACGGAGGTTGAAGGCTGCATTG
ACTCACCACCCTGCTGCCATGTCAAATGGGAACATGAACACCATGGGACACATGATGGAGATGATGGGCTCCCGGCAGGACCAGACGCCA
CACCATCACATGCACTCGCACCCGCATCAGCACCAGACACTGCCACCCCATCACCCTTACCCACACCAGCACCAGCACCCAGCACACCAT
CCTCACCCTCAACCCCATCACCAGCAGAACCATCCACATCACCACTCCCATTCCCACCTTCATGCACACCCAGCACATCACCAGACCTCG
CCACATCCGCCCCTGCACACCGGCAACCAAGCACAGGTTTCACCAGCAACACAACAGATGCAGCCAACCCAGACAATACAGCCACCCCAG
CCCACAGGGGGGCGCCGGCGAAGGGTGGTAGACGAGGATCCGGACGAGAGGCGGCGGAAATTTCTGGAACGGAACCGGGCAGCTGCCACC
CGCTGCAGACAGAAGAGGAAGGTCTGGGTGATGTCATTGGAAAAGAAAGCAGAAGAACTCACCCAGACAAACATGCAGCTTCAGAATGAA
GTGTCTATGTTGAAAAATGAGGTGGCCCAGCTGAAACAGTTGTTGTTAACACATAAAGACTGCCCAATAACAGCCATGCAGAAAGAATCA
CAAGGATATCTAAGTCCAGAGAGTAGCCCTCCTGCTAGTCCTGTCCCAGCTTGCTCCCAGCAACAAGTCATCCAGCATAATACCATCACT
ACTTCCTCATCGGTCAGCGAGGTGGTAGGAAGCTCCACCCTCAGCCAGCTCACCACTCACAGAACAGACCTGAATCCGATTCTTTAAAAT
GCACCATCAGACCTGGCCTCCAAGAAGAGCTGTAGCGTACCATGCGTCCTTTCTTTTAAGGGCATTTTTAGAATTAACTCAGACCTGGAA
GACTCCTCAGTTCTTCAAAGACTGGCTTTCATTTTTATAGTTATTATGGAAATGTTGTCTTTTATACTTAGTTATATAAGAAAAAAGGGA
GTTATGCAATTAATATCTATCAGCTTGGGAAACGCTTTGGTGCTTTTCTCCAGTTTTCTGGTACCAGTTACTTGTTTATAAACTGAACCT
TTTCTGTATATAGCCATGGTTTCATTCTTATCAGTCCAACCCTTTGCCTGAAACATTGAATCTTGTTAAACCACAGCTTTTAGCTAAAAT
GAGGTATACCTAGATGTCAAGTAAGACAGATCCAAGGTAACTGGGTAGGAAATCTTTTGACATCTTAACTCATGTTGAGTTTGTGCTGTG
GTGTCACCAGAATTCCAGATAAACACACAGCCTTTCCCATACCTTTTTTTTTCTTACTATAAAATATTATAAGATCCATTGATGTCCAAA
TAATACCACCAAGCATCTCTTCACCTCTCCTCCTCTTGGTCCACTTGCTAATGCCCAGTTTTCTTCTCCATTTCCACTTTTTCTTAGGCT

>86619_86619_4_SRSF4-CREB5_SRSF4_chr1_29508158_ENST00000373795_CREB5_chr7_28843816_ENST00000396300_length(amino acids)=287AA_BP=1
MLSFPMTSPRPSSSVCSGWQLPGSVPEISAASRPDPRLPPFAGAPLWAGVAVLSGLAASVVLLVKPVLGCRCAGADVARSGDVLGVHEGG
NGSGDVDGSAGDGVEGEDGVLGAGAGVGKGDGVAVSGADAGASACDGVASGPAGSPSSPSCVPWCSCSHLTWQQGGESMQPSTSVLQIHL
QDLPVALKEALHIALPGLVAQAADVHPRHPGNGSDGWPRPQPPLGGGGQSESTAAAAAAATGGRRDGRSRTPATYASTQLASARFHFPRP

--------------------------------------------------------------
>86619_86619_5_SRSF4-CREB5_SRSF4_chr1_29508158_ENST00000373795_CREB5_chr7_28843816_ENST00000409603_length(transcript)=1525nt_BP=342nt
GCCGAGCGGGAAGCGAACGCGCGCTCTCTCCGGTTACCTTCCGCCTCGGGGAAGGGCGGGGGAAGTGGAAGCGCGCGCTCGCGAGCTGCG
TGCTCGCGTACGTCGCCGGGGTTCGGCTGCGTCCGTCCCGCCGCCCGCCCGTTGCCGCCGCCGCCGCTGCCGCCGTGCTCTCGCTTTGCC
CGCCGCCGCCTAAGGGGGGCTGGGGCCGGGGCCAGCCATCACTGCCGTTGCCGGGATGCCGCGGGTGTACATCGGCCGCCTGAGCTACCA
GGCCCGGGAGCGCGATGTGGAGCGCTTCTTTAAGGGCTACGGGAAGATCCTGGAGGTGGATCTGAAGAACGGAGGTTGAAGGCTGCATTG
ACTCACCACCCTGCTGCCATGTCAAATGGGAACATGAACACCATGGGACACATGATGGAGATGATGGGCTCCCGGCAGGACCAGACGCCA
CACCATCACATGCACTCGCACCCGCATCAGCACCAGACACTGCCACCCCATCACCCTTACCCACACCAGCACCAGCACCCAGCACACCAT
CCTCACCCTCAACCCCATCACCAGCAGAACCATCCACATCACCACTCCCATTCCCACCTTCATGCACACCCAGCACATCACCAGACCTCG
CCACATCCGCCCCTGCACACCGGCAACCAAGCACAGGTTTCACCAGCAACACAACAGATGCAGCCAACCCAGACAATACAGCCACCCCAG
CCCACAGGGGGGCGCCGGCGAAGGGTGGTAGACGAGGATCCGGACGAGAGGCGGCGGAAATTTCTGGAACGGAACCGGGCAGCTGCCACC
CGCTGCAGACAGAAGAGGAAGGTCTGGGTGATGTCATTGGAAAAGAAAGCAGAAGAACTCACCCAGACAAACATGCAGCTTCAGAATGAA
GTGTCTATGTTGAAAAATGAGGTGGCCCAGCTGAAACAGTTGTTGTTAACACATAAAGACTGCCCAATAACAGCCATGCAGAAAGAATCA
CAAGGATATCTAAGTCCAGAGAGTAGCCCTCCTGCTAGTCCTGTCCCAGCTTGCTCCCAGCAACAAGTCATCCAGCATAATACCATCACT
ACTTCCTCATCGGTCAGCGAGGTGGTAGGAAGCTCCACCCTCAGCCAGCTCACCACTCACAGAACAGACCTGAATCCGATTCTTTAAAAT
GCACCATCAGACCTGGCCTCCAAGAAGAGCTGTAGCGTACCATGCGTCCTTTCTTTTAAGGGCATTTTTAGAATTAACTCAGACCTGGAA
GACTCCTCAGTTCTTCAAAGACTGGCTTTCATTTTTATAGTTATTATGGAAATGTTGTCTTTTATACTTAGTTATATAAGAAAAAAGGGA
GTTATGCAATTAATATCTATCAGCTTGGGAAACGCTTTGGTGCTTTTCTCCAGTTTTCTGGTACCAGTTACTTGTTTATAAACTGAACCT

>86619_86619_5_SRSF4-CREB5_SRSF4_chr1_29508158_ENST00000373795_CREB5_chr7_28843816_ENST00000409603_length(amino acids)=287AA_BP=1
MLSFPMTSPRPSSSVCSGWQLPGSVPEISAASRPDPRLPPFAGAPLWAGVAVLSGLAASVVLLVKPVLGCRCAGADVARSGDVLGVHEGG
NGSGDVDGSAGDGVEGEDGVLGAGAGVGKGDGVAVSGADAGASACDGVASGPAGSPSSPSCVPWCSCSHLTWQQGGESMQPSTSVLQIHL
QDLPVALKEALHIALPGLVAQAADVHPRHPGNGSDGWPRPQPPLGGGGQSESTAAAAAAATGGRRDGRSRTPATYASTQLASARFHFPRP

--------------------------------------------------------------
>86619_86619_6_SRSF4-CREB5_SRSF4_chr1_29508158_ENST00000546138_CREB5_chr7_28843816_ENST00000357727_length(transcript)=7693nt_BP=253nt
GTGCTCGCGTACGTCGCCGGGGTTCGGCTGCGTCCGTCCCGCCGCCCGCCCGTTGCCGCCGCCGCCGCTGCCGCCGTGCTCTCGCTTTGC
CCGCCGCCGCCTAAGGGGGGCTGGGGCCGGGGCCAGCCATCACTGCCGTTGCCGGGATGCCGCGGGTGTACATCGGCCGCCTGAGCTACC
AGGCCCGGGAGCGCGATGTGGAGCGCTTCTTTAAGGGCTACGGGAAGATCCTGGAGGTGGATCTGAAGAACGGAGGTTGAAGGCTGCATT
GACTCACCACCCTGCTGCCATGTCAAATGGGAACATGAACACCATGGGACACATGATGGAGATGATGGGCTCCCGGCAGGACCAGACGCC
ACACCATCACATGCACTCGCACCCGCATCAGCACCAGACACTGCCACCCCATCACCCTTACCCACACCAGCACCAGCACCCAGCACACCA
TCCTCACCCTCAACCCCATCACCAGCAGAACCATCCACATCACCACTCCCATTCCCACCTTCATGCACACCCAGCACATCACCAGACCTC
GCCACATCCGCCCCTGCACACCGGCAACCAAGCACAGGTTTCACCAGCAACACAACAGATGCAGCCAACCCAGACAATACAGCCACCCCA
GCCCACAGGGGGGCGCCGGCGAAGGGTGGTAGACGAGGATCCGGACGAGAGGCGGCGGAAATTTCTGGAACGGAACCGGGCAGCTGCCAC
CCGCTGCAGACAGAAGAGGAAGGTCTGGGTGATGTCATTGGAAAAGAAAGCAGAAGAACTCACCCAGACAAACATGCAGCTTCAGAATGA
AGTGTCTATGTTGAAAAATGAGGTGGCCCAGCTGAAACAGTTGTTGTTAACACATAAAGACTGCCCAATAACAGCCATGCAGAAAGAATC
ACAAGGATATCTAAGTCCAGAGAGTAGCCCTCCTGCTAGTCCTGTCCCAGCTTGCTCCCAGCAACAAGTCATCCAGCATAATACCATCAC
TACTTCCTCATCGGTCAGCGAGGTGGTAGGAAGCTCCACCCTCAGCCAGCTCACCACTCACAGAACAGACCTGAATCCGATTCTTTAAAA
TGCACCATCAGACCTGGCCTCCAAGAAGAGCTGTAGCGTACCATGCGTCCTTTCTTTTAAGGGCATTTTTAGAATTAACTCAGACCTGGA
AGACTCCTCAGTTCTTCAAAGACTGGCTTTCATTTTTATAGTTATTATGGAAATGTTGTCTTTTATACTTAGTTATATAAGAAAAAAGGG
AGTTATGCAATTAATATCTATCAGCTTGGGAAACGCTTTGGTGCTTTTCTCCAGTTTTCTGGTACCAGTTACTTGTTTATAAACTGAACC
TTTTCTGTATATAGCCATGGTTTCATTCTTATCAGTCCAACCCTTTGCCTGAAACATTGAATCTTGTTAAACCACAGCTTTTAGCTAAAA
TGAGGTATACCTAGATGTCAAGTAAGACAGATCCAAGGTAACTGGGTAGGAAATCTTTTGACATCTTAACTCATGTTGAGTTTGTGCTGT
GGTGTCACCAGAATTCCAGATAAACACACAGCCTTTCCCATACCTTTTTTTTTCTTACTATAAAATATTATAAGATCCATTGATGTCCAA
ATAATACCACCAAGCATCTCTTCACCTCTCCTCCTCTTGGTCCACTTGCTAATGCCCAGTTTTCTTCTCCATTTCCACTTTTTCTTAGGC
TCCCTATTTACTATTCATTTTGACTTCCTTCTGTTTTATTTTTTTCCCTTTAGCATTGCATGTGAATAAGAAAATAATGTTTAAAGAAAA
AAAAAAAAAAGCAAACCTCCAAAACGTGGACCTAACCATTGCTTCACTTACACTTCACCCACAGCTGGAGTTCATTCAACTCTTGCTTTT
CACAAAATAGTAACCAGGAGATGTTTAATGTGCCTGATTTAATGTTTTTAATAATCACAGCAAATGAAAGGTGGTTTAGTTATAAGTGAA
GCATGGTTGAATACCAGCTGGGGAGACACTAGGGAAGGGAGCTTTGTAAGCCTTGATTGCGAAAGTCCAAATTTTGATGTGGGGCTATAA
CATGACACCCTTGGATTGCGACTGGTTTTATACGGCCTGCCTATAACGTTGAAAATCCATGTACTACATAATAATTCAGAAGGGCTCTAT
TCACTACACAGATTACATTGTTCAATCATCAGCTGCTAATAGCCTAAGATTTATTTTTTTTTTTTTCTTAAGCCTATGGAACCGGCTTTG
CTGTTCTGGGGGGTGAAAATAGACTAACTACTGGAGAAACAAAGAGAGAAAGAAAACCCAGTGTTTCCATAGGGGCACTTTTAGCCTTCC
CACAACAGTTAAGCACTCTTTGACTGCTGAAGGAACCCCATGGATGAGGTGCAGGCTACTTCACTCTTTTTTTTTCTTTTTTGAGACAGA
GTCTCACCTATTGCCCAGACTGAAGTGCAGTGGTGCGATCATGGATCACTGCAGCAGCATCCTCCGAGTTCAAGCTATCCTTCCACCTCC
GCCTCCTGAGTAGCTGGGACCACAGGTTCACATAACCATGCCTGGCTAATTTATTTTTACTTTTATTTTAAAATAAAAGATGAGGTCTGT
CTTATGTTGCCCAGGCTGGTCTCAAACTATCCTACTTCTTCCTCCCAAAGTGTTGGGATTATAGGTGTGAGCCACTGCACCCAGCCTACT
TCACTCTTCTGAATTATTCTGATTTATTTTCAACAACTTTTGTGAACTTGCCCGTGATACAAAGCAGATAGTCCCTGAACCACAGTCGTG
CCTCCTTGAAACAAGCCATTCTACTGTGCTAATGTTTTAATATCACATCTCACAAATAACAGGGGTGAATGTTTCTCTCTAGCAATCTAG
GCAGGTGCTGGTGTTTCATCTCCATTTGAATGCTTGACCTCTTAATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTTCATGGGTTTTA
AAAGAACAGTATTTTACAAAAGGTGTAGCTTTTATAAGAGTGCAGAAAAGGGAAGGATGTGTTTTTTTCTCTCACTATAGTATAAGAATC
TATTTTGGAGAAAAAAAGAAAATATGAGGGTCTCGAAGCATGATTTTTATATAACTAGTTTCAGTTTTATCTAATAACTTACTTTTTAAA
TCAATATTTATCAACAATCTTTCCTTGTATGCAGTGCTTTCAAAAGATGGTTTTGAGTGTCCAGTGAAACTTATGACTTGGATATATGGT
TGAAGAATCAAAACAAAAGCAAAAAAAAAAAGCAAAAAAAGAAAAGAGAAAAAAAGAAAAAATGCAAATGGAATAATTTTCTATTATATT
TTAGACAAACATATCATTTTCGAGTATTTTAAATACTGAATTCATAGTTGTTGTTTTTTAAATTCCAACAGTAACAGCTGAATGGTTTAA
TCTGACTGGCTTCCTAAGAAATGTTTAAGACTCAGCTTTAAAAAGAAGTTAACATTCATATCTCTGTTTTGAAATCAAAAATCATATTTC
AAAATTCTTTCCTAGGACCATCTATGTGTCTCCCCTCCCCTCCACAAAAAGGAGAAAGAGTGCATTAAAATGTTTAGTTGGGTTTTTTAA
TTTTTAATTTTTATGTTATGTTTTGCTTTGTTTTAAGTAAACAAAAATTTTTCTTTCTTTACTGCATGCATAGCACTTAATAAAATGGAT
TTTTAAAAAATCCACTAGTAATATCAGAATGTCCAGGGAGTGACTGTCACTACAATGATGGTTTAGTTTACTTCTGTTCCACCTTTTGAT
TGAAATATTTAGTTGTTAGGCTGAAAGCCTCGGCAGTTAAGAACTTGCCTGAGTTTTCTTCGTTCAGCAACTTGACAGTTTGACTGATGT
GCATTATATATAGCTCAATTATGTCTGTTTTTTATGCTAAGTAGGAAAACCAACCACACACATTAGCAAACCGGCCTCAACATATAATTA
GAATAAACTGTCTTCTTGTTCTACTCAGGGCCTTTAGGTGTGTTCATTCACGGTATGGAAATACAGTAAATGAAAGATTCCAACTAGTTG
TCAGTGCTTCTTGAAATTCCAAACAGAAAGATACATTGGTCAAATCCAACACTTGGCTTATCAATATTAAGTCTTTTACCTAAAGGCCCA
GCCGTCACCAGACAACAGAATAATCAATCTGCCTGAAAATCCCTCCTCCTTGTCCTACACTTTTTGCCTGTTTGGGAGAATATCTTTGTA
CTCCATTCTCCTCCCTCAGCCAGTTACTGGGTCACCCATCCATGTGTTCATGAATCAATCATCACGGCCTGCAGAGCACCTGTCCTAAGG
AGGGAAAATCCTGTCACACTGCCTCTCCCCATTCGTGTGTGGTTTTCTTGATCGGTGAGATCTGTCTCTGAAGTCACTGCCAGCCTCCCT
GGGAACGTCTATAGTGCCTCCCCTGCCTTATGTGATGGGAGTTAACAACTCAGATAAGTACACCTGAGAGCATTTCTATCAGGTAAACTG
TCACTTAAATGGAGGTGTCCACATCTTAATTGTTTCTCCTTGACACATTTCTCAATCCACGAAGCCAGGAGAGGTAGAGTGAAAATCCCA
GCCATGGATGAATGTACTAATTTGAAAGCCAAGTGTTAAGTCGGATGTTTTCCCGTTACACTACTACTCAGCCCTCTCCTGCGGCCACAT
CAACGGATGCAAGTCACAGTCTTAACACAGCCTGTGGGAGACAAGCAGTTTGTGTGCTCACAGTATATATTATAGTAATTAGGGTGACTT
AGAGCAAATACTCTTCAGATCCTATGTAGTCAGTGAAACAAAATGGAGAGCGTATTCTGATAGAAGGACGTCGACGGTGAATGTTCTGGT
GGTTGTTGCCTGTTAAGTAAACTTTAGTGTGTAAGTTGAGTTTGTCATTAAAATCATAAACCAGCTGCGGTAACAGACAAGCCTTTGGCT
GGGGAGTTTTAAGCCTCGGTAACTGCTATAAAACTAGCCATCCAGTTAGGATAGAATGTGTTTCTTTCTGGTTAAAAAAAGGAAAAACCA
TCTAAGAAAATATATATGTATGTATGTGTGTATACAGTGGAATTCAAAGGACCAAAGCAAAATTTGAACAGGAATCTATTAATTTAGAAT
TTTATAAGATATTTATTAATAAATGTTATTTTTAAACATTCCATTTGAACAGTATTCTGTAGGATCTACTTGTTTTTAAAGTGTTAGTCC
ATAATAAACTACTATAGTTATGTGTATTTTCATTTTTCAGGGTTTCAAATGGCTATTCTCCATCATTTGGTGGAAATGTTTGCTTAGATC
TCTGTGCATAGACATTTCAAGGATTTTTATTGCTCTGTGAGTTATTTTTTAATCAACATTCTGAACAGTTTTTTTTAAACATTTATTTCT
GTGTGTTCATTTTTAAAGTAAGCTCTTTCATTTAGGAAGCAGAGTTCAGCTAAAGGGAATCAGTAACTCTAACTGGAACAGCTTTCTTGT
AGAAGTGTAAAAACAGCTTCATCTCTGCCTCTCTCCACCCCACCCCAATTTCCTAGAAAGCCTTGCACTATTCAGCTCCCTTAGTGCTTT
TTGTCCCTTCCCGAACAATATGCAGTAGCTTTAAGCCATTCAAGCTCCATTATGCAGTATATCTGAGAAGGGAAAGGAAACAACCCATTT
AAATTTGAATAAAACCGTGCCTATGCGAACAGTAGCAATTTAGAATCTCTTTTCTGCTTTTAAAATAATTTATATTTAAAAATTGCACTT
TAGCTTTTTGATCCCTTTGTATTTCTCTTATTCTCTTTCTAACCTCTTCTCTGTCCTCAAACTTGCCTTTGCTCTCCTTTACAATACCCC
CCACCCCTCCTCCAAGGCTCTGAGCGGCATCATTTAAAATACTTTACAGATATTTGCACCAGGTACATTTATGTGCGTCCATTGGTAGCA
CAGCTGAGACCTGTGTCTCACATCAGCCTAGGTGAAGCCTACTACAAGAATGCCAAGGAGAAGAGCCAGTACACTATATGGTTTATACTC
TTTATCCCTTTATTCATAGCATGTTTTTTAAAAATGTTATATTATGCAACAGATGTGAGGCAGCAGCTAAGCTATACTTAAGAATTTTCT
CTCACCTTCCAAACCAAAGTGTCCTGAATAAGCCAGGAGACTTATTCTTTTGTGCACCCTGGTGCACATCTGACTGTTGTCCTAGCCATA
GACTCTCTGAGGCCACTGAAAGAACAGTGGCCCTATCGATTTCATTCCTAGGTCTCAAAAATACAATGTTGCCTTGTAACATAATTAGGG
ACAGCACCTCTATTTCACAATTATAATCTAAGGTAGGATAAGACGACACAGCAGCAATAAACTTACAAGTAAAATTCAATACCAAAACAA
ACACAAAGAAATTTAAAAAACAAAAAACCTAGCTCATCATGTTGTGAAAATGAAAAAGTGAATGTCCATTCAAAATATTTTACTATTTCT
TGTGGAGTTTTTCAGTGATGTAATGCTTGTAGCCAAATTGCTTAAAGAGTGTTTATATATTTTTTTCCTTATAAATTGTCTATTTTTTAA
AAAAGCTATTTAACCACAGCTGAAGTGGGGGGTAAGGCCAAATTGCCAACACTTGTTAAAAGATTAATACTCTTAAGTGGCACTCTGATA
CCTTTCCAACTTGTCATCAGAAAGGAATCAATAATTACCAACTGTTGTATTTAGACCAACTTACAATATCTAGCTCATTAGAAGCCAGGA
TCTAGAAAGCTCCTTCTAAGCCATTTAAGATATTCTTACATTGAGCTTCATATTATAGAACTTTATAGGATTGGATATTTTACAATAGAA
TAATTTAGCCTCAGGACTGAGAATGTGGAAGCTGAATAAATTAGCTTTAAATACATCATTAAAATCTTATGCACAATAAGCTCATTAGAT
TCTAGTTTTCTCCTTTAGAATACCAATGCCACAGACACTACAGGAGATAATGAAAGGTATCAGTTGTGTTGAGTGGAGGGAGTTTAAGAG
AAAGGACCCTTCCCAACCAGCAGCCAGTAGAAAATACAACCTACTCACCTTTTTCCCTTCTAAGTTCTGCTAAATCACATCTGCCTCATA
GAGAAAGGAATGTTGCCTTTGAGAACTGTCTTGGAGAACAGATAAGCTTGAAATGTTCTCTCTAGAGAGGACATAGGGTTTGGGATCCTC
TGAAAAGGCCCAGAAAAATAGCTCAGTTCAAATACAATGTTCTAGGACAATTGGAATATAAATATTGTCCAAAAATATAATTAAAAGAAA
AAAGTTTAGCACTGTGTAAAGTAAGTGTTAACTGAGGAAGTCCCAAAAAGGTGCTGTCACTTTAAGTTCTGGACTTGGGGTTCTTTGTAT
TTGTAAACAGCAAAGCATTTGTGTTTGTTTGTCTATTTGTAAAGCAACCACCTTCCTTATTGGAAGGAGAAAAAAAGGGGTACATACATG
TAAATACTTGCTGCAGCATTTAATATGTTTAATTTTGTGTTAAGCTTTTTGTTGCATCGTGAACACATTTATTGTTACCAATGGACAATG
AGTTCATTAAGACTGTTCAACTAGGTCAGATTTTTACATCTCTTTCTAGCAAGAAGAGACAAGATTTTGTGCATTTGTACAAATGTTAAT

>86619_86619_6_SRSF4-CREB5_SRSF4_chr1_29508158_ENST00000546138_CREB5_chr7_28843816_ENST00000357727_length(amino acids)=273AA_BP=1
MKAALTHHPAAMSNGNMNTMGHMMEMMGSRQDQTPHHHMHSHPHQHQTLPPHHPYPHQHQHPAHHPHPQPHHQQNHPHHHSHSHLHAHPA
HHQTSPHPPLHTGNQAQVSPATQQMQPTQTIQPPQPTGGRRRRVVDEDPDERRRKFLERNRAAATRCRQKRKVWVMSLEKKAEELTQTNM
QLQNEVSMLKNEVAQLKQLLLTHKDCPITAMQKESQGYLSPESSPPASPVPACSQQQVIQHNTITTSSSVSEVVGSSTLSQLTTHRTDLN

--------------------------------------------------------------
>86619_86619_7_SRSF4-CREB5_SRSF4_chr1_29508158_ENST00000546138_CREB5_chr7_28843816_ENST00000396298_length(transcript)=1799nt_BP=253nt
GTGCTCGCGTACGTCGCCGGGGTTCGGCTGCGTCCGTCCCGCCGCCCGCCCGTTGCCGCCGCCGCCGCTGCCGCCGTGCTCTCGCTTTGC
CCGCCGCCGCCTAAGGGGGGCTGGGGCCGGGGCCAGCCATCACTGCCGTTGCCGGGATGCCGCGGGTGTACATCGGCCGCCTGAGCTACC
AGGCCCGGGAGCGCGATGTGGAGCGCTTCTTTAAGGGCTACGGGAAGATCCTGGAGGTGGATCTGAAGAACGGAGGTTGAAGGCTGCATT
GACTCACCACCCTGCTGCCATGTCAAATGGGAACATGAACACCATGGGACACATGATGGAGATGATGGGCTCCCGGCAGGACCAGACGCC
ACACCATCACATGCACTCGCACCCGCATCAGCACCAGACACTGCCACCCCATCACCCTTACCCACACCAGCACCAGCACCCAGCACACCA
TCCTCACCCTCAACCCCATCACCAGCAGAACCATCCACATCACCACTCCCATTCCCACCTTCATGCACACCCAGCACATCACCAGACCTC
GCCACATCCGCCCCTGCACACCGGCAACCAAGCACAGGTTTCACCAGCAACACAACAGATGCAGCCAACCCAGACAATACAGCCACCCCA
GCCCACAGGGGGGCGCCGGCGAAGGGTGGTAGACGAGGATCCGGACGAGAGGCGGCGGAAATTTCTGGAACGGAACCGGGCAGCTGCCAC
CCGCTGCAGACAGAAGAGGAAGGTCTGGGTGATGTCATTGGAAAAGAAAGCAGAAGAACTCACCCAGACAAACATGCAGCTTCAGAATGA
AGTGTCTATGTTGAAAAATGAGGTGGCCCAGCTGAAACAGTTGTTGTTAACACATAAAGACTGCCCAATAACAGCCATGCAGAAAGAATC
ACAAGGATATCTAAGTCCAGAGAGTAGCCCTCCTGCTAGTCCTGTCCCAGCTTGCTCCCAGCAACAAGTCATCCAGCATAATACCATCAC
TACTTCCTCATCGGTCAGCGAGGTGGTAGGAAGCTCCACCCTCAGCCAGCTCACCACTCACAGAACAGACCTGAATCCGATTCTTTAAAA
TGCACCATCAGACCTGGCCTCCAAGAAGAGCTGTAGCGTACCATGCGTCCTTTCTTTTAAGGGCATTTTTAGAATTAACTCAGACCTGGA
AGACTCCTCAGTTCTTCAAAGACTGGCTTTCATTTTTATAGTTATTATGGAAATGTTGTCTTTTATACTTAGTTATATAAGAAAAAAGGG
AGTTATGCAATTAATATCTATCAGCTTGGGAAACGCTTTGGTGCTTTTCTCCAGTTTTCTGGTACCAGTTACTTGTTTATAAACTGAACC
TTTTCTGTATATAGCCATGGTTTCATTCTTATCAGTCCAACCCTTTGCCTGAAACATTGAATCTTGTTAAACCACAGCTTTTAGCTAAAA
TGAGGTATACCTAGATGTCAAGTAAGACAGATCCAAGGTAACTGGGTAGGAAATCTTTTGACATCTTAACTCATGTTGAGTTTGTGCTGT
GGTGTCACCAGAATTCCAGATAAACACACAGCCTTTCCCATACCTTTTTTTTTCTTACTATAAAATATTATAAGATCCATTGATGTCCAA
ATAATACCACCAAGCATCTCTTCACCTCTCCTCCTCTTGGTCCACTTGCTAATGCCCAGTTTTCTTCTCCATTTCCACTTTTTCTTAGGC

>86619_86619_7_SRSF4-CREB5_SRSF4_chr1_29508158_ENST00000546138_CREB5_chr7_28843816_ENST00000396298_length(amino acids)=273AA_BP=1
MKAALTHHPAAMSNGNMNTMGHMMEMMGSRQDQTPHHHMHSHPHQHQTLPPHHPYPHQHQHPAHHPHPQPHHQQNHPHHHSHSHLHAHPA
HHQTSPHPPLHTGNQAQVSPATQQMQPTQTIQPPQPTGGRRRRVVDEDPDERRRKFLERNRAAATRCRQKRKVWVMSLEKKAEELTQTNM
QLQNEVSMLKNEVAQLKQLLLTHKDCPITAMQKESQGYLSPESSPPASPVPACSQQQVIQHNTITTSSSVSEVVGSSTLSQLTTHRTDLN

--------------------------------------------------------------
>86619_86619_8_SRSF4-CREB5_SRSF4_chr1_29508158_ENST00000546138_CREB5_chr7_28843816_ENST00000396299_length(transcript)=1799nt_BP=253nt
GTGCTCGCGTACGTCGCCGGGGTTCGGCTGCGTCCGTCCCGCCGCCCGCCCGTTGCCGCCGCCGCCGCTGCCGCCGTGCTCTCGCTTTGC
CCGCCGCCGCCTAAGGGGGGCTGGGGCCGGGGCCAGCCATCACTGCCGTTGCCGGGATGCCGCGGGTGTACATCGGCCGCCTGAGCTACC
AGGCCCGGGAGCGCGATGTGGAGCGCTTCTTTAAGGGCTACGGGAAGATCCTGGAGGTGGATCTGAAGAACGGAGGTTGAAGGCTGCATT
GACTCACCACCCTGCTGCCATGTCAAATGGGAACATGAACACCATGGGACACATGATGGAGATGATGGGCTCCCGGCAGGACCAGACGCC
ACACCATCACATGCACTCGCACCCGCATCAGCACCAGACACTGCCACCCCATCACCCTTACCCACACCAGCACCAGCACCCAGCACACCA
TCCTCACCCTCAACCCCATCACCAGCAGAACCATCCACATCACCACTCCCATTCCCACCTTCATGCACACCCAGCACATCACCAGACCTC
GCCACATCCGCCCCTGCACACCGGCAACCAAGCACAGGTTTCACCAGCAACACAACAGATGCAGCCAACCCAGACAATACAGCCACCCCA
GCCCACAGGGGGGCGCCGGCGAAGGGTGGTAGACGAGGATCCGGACGAGAGGCGGCGGAAATTTCTGGAACGGAACCGGGCAGCTGCCAC
CCGCTGCAGACAGAAGAGGAAGGTCTGGGTGATGTCATTGGAAAAGAAAGCAGAAGAACTCACCCAGACAAACATGCAGCTTCAGAATGA
AGTGTCTATGTTGAAAAATGAGGTGGCCCAGCTGAAACAGTTGTTGTTAACACATAAAGACTGCCCAATAACAGCCATGCAGAAAGAATC
ACAAGGATATCTAAGTCCAGAGAGTAGCCCTCCTGCTAGTCCTGTCCCAGCTTGCTCCCAGCAACAAGTCATCCAGCATAATACCATCAC
TACTTCCTCATCGGTCAGCGAGGTGGTAGGAAGCTCCACCCTCAGCCAGCTCACCACTCACAGAACAGACCTGAATCCGATTCTTTAAAA
TGCACCATCAGACCTGGCCTCCAAGAAGAGCTGTAGCGTACCATGCGTCCTTTCTTTTAAGGGCATTTTTAGAATTAACTCAGACCTGGA
AGACTCCTCAGTTCTTCAAAGACTGGCTTTCATTTTTATAGTTATTATGGAAATGTTGTCTTTTATACTTAGTTATATAAGAAAAAAGGG
AGTTATGCAATTAATATCTATCAGCTTGGGAAACGCTTTGGTGCTTTTCTCCAGTTTTCTGGTACCAGTTACTTGTTTATAAACTGAACC
TTTTCTGTATATAGCCATGGTTTCATTCTTATCAGTCCAACCCTTTGCCTGAAACATTGAATCTTGTTAAACCACAGCTTTTAGCTAAAA
TGAGGTATACCTAGATGTCAAGTAAGACAGATCCAAGGTAACTGGGTAGGAAATCTTTTGACATCTTAACTCATGTTGAGTTTGTGCTGT
GGTGTCACCAGAATTCCAGATAAACACACAGCCTTTCCCATACCTTTTTTTTTCTTACTATAAAATATTATAAGATCCATTGATGTCCAA
ATAATACCACCAAGCATCTCTTCACCTCTCCTCCTCTTGGTCCACTTGCTAATGCCCAGTTTTCTTCTCCATTTCCACTTTTTCTTAGGC

>86619_86619_8_SRSF4-CREB5_SRSF4_chr1_29508158_ENST00000546138_CREB5_chr7_28843816_ENST00000396299_length(amino acids)=273AA_BP=1
MKAALTHHPAAMSNGNMNTMGHMMEMMGSRQDQTPHHHMHSHPHQHQTLPPHHPYPHQHQHPAHHPHPQPHHQQNHPHHHSHSHLHAHPA
HHQTSPHPPLHTGNQAQVSPATQQMQPTQTIQPPQPTGGRRRRVVDEDPDERRRKFLERNRAAATRCRQKRKVWVMSLEKKAEELTQTNM
QLQNEVSMLKNEVAQLKQLLLTHKDCPITAMQKESQGYLSPESSPPASPVPACSQQQVIQHNTITTSSSVSEVVGSSTLSQLTTHRTDLN

--------------------------------------------------------------
>86619_86619_9_SRSF4-CREB5_SRSF4_chr1_29508158_ENST00000546138_CREB5_chr7_28843816_ENST00000396300_length(transcript)=1799nt_BP=253nt
GTGCTCGCGTACGTCGCCGGGGTTCGGCTGCGTCCGTCCCGCCGCCCGCCCGTTGCCGCCGCCGCCGCTGCCGCCGTGCTCTCGCTTTGC
CCGCCGCCGCCTAAGGGGGGCTGGGGCCGGGGCCAGCCATCACTGCCGTTGCCGGGATGCCGCGGGTGTACATCGGCCGCCTGAGCTACC
AGGCCCGGGAGCGCGATGTGGAGCGCTTCTTTAAGGGCTACGGGAAGATCCTGGAGGTGGATCTGAAGAACGGAGGTTGAAGGCTGCATT
GACTCACCACCCTGCTGCCATGTCAAATGGGAACATGAACACCATGGGACACATGATGGAGATGATGGGCTCCCGGCAGGACCAGACGCC
ACACCATCACATGCACTCGCACCCGCATCAGCACCAGACACTGCCACCCCATCACCCTTACCCACACCAGCACCAGCACCCAGCACACCA
TCCTCACCCTCAACCCCATCACCAGCAGAACCATCCACATCACCACTCCCATTCCCACCTTCATGCACACCCAGCACATCACCAGACCTC
GCCACATCCGCCCCTGCACACCGGCAACCAAGCACAGGTTTCACCAGCAACACAACAGATGCAGCCAACCCAGACAATACAGCCACCCCA
GCCCACAGGGGGGCGCCGGCGAAGGGTGGTAGACGAGGATCCGGACGAGAGGCGGCGGAAATTTCTGGAACGGAACCGGGCAGCTGCCAC
CCGCTGCAGACAGAAGAGGAAGGTCTGGGTGATGTCATTGGAAAAGAAAGCAGAAGAACTCACCCAGACAAACATGCAGCTTCAGAATGA
AGTGTCTATGTTGAAAAATGAGGTGGCCCAGCTGAAACAGTTGTTGTTAACACATAAAGACTGCCCAATAACAGCCATGCAGAAAGAATC
ACAAGGATATCTAAGTCCAGAGAGTAGCCCTCCTGCTAGTCCTGTCCCAGCTTGCTCCCAGCAACAAGTCATCCAGCATAATACCATCAC
TACTTCCTCATCGGTCAGCGAGGTGGTAGGAAGCTCCACCCTCAGCCAGCTCACCACTCACAGAACAGACCTGAATCCGATTCTTTAAAA
TGCACCATCAGACCTGGCCTCCAAGAAGAGCTGTAGCGTACCATGCGTCCTTTCTTTTAAGGGCATTTTTAGAATTAACTCAGACCTGGA
AGACTCCTCAGTTCTTCAAAGACTGGCTTTCATTTTTATAGTTATTATGGAAATGTTGTCTTTTATACTTAGTTATATAAGAAAAAAGGG
AGTTATGCAATTAATATCTATCAGCTTGGGAAACGCTTTGGTGCTTTTCTCCAGTTTTCTGGTACCAGTTACTTGTTTATAAACTGAACC
TTTTCTGTATATAGCCATGGTTTCATTCTTATCAGTCCAACCCTTTGCCTGAAACATTGAATCTTGTTAAACCACAGCTTTTAGCTAAAA
TGAGGTATACCTAGATGTCAAGTAAGACAGATCCAAGGTAACTGGGTAGGAAATCTTTTGACATCTTAACTCATGTTGAGTTTGTGCTGT
GGTGTCACCAGAATTCCAGATAAACACACAGCCTTTCCCATACCTTTTTTTTTCTTACTATAAAATATTATAAGATCCATTGATGTCCAA
ATAATACCACCAAGCATCTCTTCACCTCTCCTCCTCTTGGTCCACTTGCTAATGCCCAGTTTTCTTCTCCATTTCCACTTTTTCTTAGGC

>86619_86619_9_SRSF4-CREB5_SRSF4_chr1_29508158_ENST00000546138_CREB5_chr7_28843816_ENST00000396300_length(amino acids)=273AA_BP=1
MKAALTHHPAAMSNGNMNTMGHMMEMMGSRQDQTPHHHMHSHPHQHQTLPPHHPYPHQHQHPAHHPHPQPHHQQNHPHHHSHSHLHAHPA
HHQTSPHPPLHTGNQAQVSPATQQMQPTQTIQPPQPTGGRRRRVVDEDPDERRRKFLERNRAAATRCRQKRKVWVMSLEKKAEELTQTNM
QLQNEVSMLKNEVAQLKQLLLTHKDCPITAMQKESQGYLSPESSPPASPVPACSQQQVIQHNTITTSSSVSEVVGSSTLSQLTTHRTDLN

--------------------------------------------------------------
>86619_86619_10_SRSF4-CREB5_SRSF4_chr1_29508158_ENST00000546138_CREB5_chr7_28843816_ENST00000409603_length(transcript)=1436nt_BP=253nt
GTGCTCGCGTACGTCGCCGGGGTTCGGCTGCGTCCGTCCCGCCGCCCGCCCGTTGCCGCCGCCGCCGCTGCCGCCGTGCTCTCGCTTTGC
CCGCCGCCGCCTAAGGGGGGCTGGGGCCGGGGCCAGCCATCACTGCCGTTGCCGGGATGCCGCGGGTGTACATCGGCCGCCTGAGCTACC
AGGCCCGGGAGCGCGATGTGGAGCGCTTCTTTAAGGGCTACGGGAAGATCCTGGAGGTGGATCTGAAGAACGGAGGTTGAAGGCTGCATT
GACTCACCACCCTGCTGCCATGTCAAATGGGAACATGAACACCATGGGACACATGATGGAGATGATGGGCTCCCGGCAGGACCAGACGCC
ACACCATCACATGCACTCGCACCCGCATCAGCACCAGACACTGCCACCCCATCACCCTTACCCACACCAGCACCAGCACCCAGCACACCA
TCCTCACCCTCAACCCCATCACCAGCAGAACCATCCACATCACCACTCCCATTCCCACCTTCATGCACACCCAGCACATCACCAGACCTC
GCCACATCCGCCCCTGCACACCGGCAACCAAGCACAGGTTTCACCAGCAACACAACAGATGCAGCCAACCCAGACAATACAGCCACCCCA
GCCCACAGGGGGGCGCCGGCGAAGGGTGGTAGACGAGGATCCGGACGAGAGGCGGCGGAAATTTCTGGAACGGAACCGGGCAGCTGCCAC
CCGCTGCAGACAGAAGAGGAAGGTCTGGGTGATGTCATTGGAAAAGAAAGCAGAAGAACTCACCCAGACAAACATGCAGCTTCAGAATGA
AGTGTCTATGTTGAAAAATGAGGTGGCCCAGCTGAAACAGTTGTTGTTAACACATAAAGACTGCCCAATAACAGCCATGCAGAAAGAATC
ACAAGGATATCTAAGTCCAGAGAGTAGCCCTCCTGCTAGTCCTGTCCCAGCTTGCTCCCAGCAACAAGTCATCCAGCATAATACCATCAC
TACTTCCTCATCGGTCAGCGAGGTGGTAGGAAGCTCCACCCTCAGCCAGCTCACCACTCACAGAACAGACCTGAATCCGATTCTTTAAAA
TGCACCATCAGACCTGGCCTCCAAGAAGAGCTGTAGCGTACCATGCGTCCTTTCTTTTAAGGGCATTTTTAGAATTAACTCAGACCTGGA
AGACTCCTCAGTTCTTCAAAGACTGGCTTTCATTTTTATAGTTATTATGGAAATGTTGTCTTTTATACTTAGTTATATAAGAAAAAAGGG
AGTTATGCAATTAATATCTATCAGCTTGGGAAACGCTTTGGTGCTTTTCTCCAGTTTTCTGGTACCAGTTACTTGTTTATAAACTGAACC

>86619_86619_10_SRSF4-CREB5_SRSF4_chr1_29508158_ENST00000546138_CREB5_chr7_28843816_ENST00000409603_length(amino acids)=273AA_BP=1
MKAALTHHPAAMSNGNMNTMGHMMEMMGSRQDQTPHHHMHSHPHQHQTLPPHHPYPHQHQHPAHHPHPQPHHQQNHPHHHSHSHLHAHPA
HHQTSPHPPLHTGNQAQVSPATQQMQPTQTIQPPQPTGGRRRRVVDEDPDERRRKFLERNRAAATRCRQKRKVWVMSLEKKAEELTQTNM
QLQNEVSMLKNEVAQLKQLLLTHKDCPITAMQKESQGYLSPESSPPASPVPACSQQQVIQHNTITTSSSVSEVVGSSTLSQLTTHRTDLN

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SRSF4-CREB5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SRSF4-CREB5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SRSF4-CREB5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource