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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SRSF5-ACSL5 (FusionGDB2 ID:86625)

Fusion Gene Summary for SRSF5-ACSL5

Fusion gene summary

Fusion gene information	Fusion gene name: SRSF5-ACSL5
	Fusion gene ID: 86625
		Hgene	Tgene
	Gene symbol	SRSF5	ACSL5
	Gene ID	6430	51703
	Gene name	serine and arginine rich splicing factor 5	acyl-CoA synthetase long chain family member 5
	Synonyms	HRS\|SFRS5\|SRP40	ACS2\|ACS5\|FACL5
	Cytomap	14q24.1	10q25.2
	Type of gene	protein-coding	protein-coding
	Description	serine/arginine-rich splicing factor 5SR splicing factor 5delayed-early protein HRSpre-mRNA-splicing factor SRP40splicing factor, arginine/serine-rich 5	long-chain-fatty-acid--CoA ligase 5FACL5 for fatty acid coenzyme A ligase 5LACS 5arachidonate--CoA ligasefatty acid coenzyme A ligase 5fatty-acid-Coenzyme A ligase, long-chain 5long-chain acyl-CoA synthetase 5long-chain fatty acid coenzyme A ligase
	Modification date	20200320	20200313
	UniProtAcc	.	Q9ULC5
	Ensembl transtripts involved in fusion gene	ENST00000555349, ENST00000394366, ENST00000451983, ENST00000553521, ENST00000553548, ENST00000553635, ENST00000554021, ENST00000556587, ENST00000557154,	ENST00000354273, ENST00000354655, ENST00000356116, ENST00000369410, ENST00000393081, ENST00000433418, ENST00000479936,
Fusion gene scores	* DoF score	12 X 8 X 6=576	9 X 10 X 7=630
	# samples	11	10
	** MAII score	log2(11/576*10)=-2.38856528791765 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/630*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SRSF5 [Title/Abstract] AND ACSL5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SRSF5(70236008)-ACSL5(114165753), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ACSL5	GO:0001676	long-chain fatty acid metabolic process	24269233

Fusion gene breakpoints across SRSF5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ACSL5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	BP317717	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+

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Fusion Gene ORF analysis for SRSF5-ACSL5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-intron	ENST00000555349	ENST00000354273	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
3UTR-intron	ENST00000555349	ENST00000354655	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
3UTR-intron	ENST00000555349	ENST00000356116	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
3UTR-intron	ENST00000555349	ENST00000369410	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
3UTR-intron	ENST00000555349	ENST00000393081	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
3UTR-intron	ENST00000555349	ENST00000433418	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
3UTR-intron	ENST00000555349	ENST00000479936	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000394366	ENST00000354273	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000394366	ENST00000354655	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000394366	ENST00000356116	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000394366	ENST00000369410	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000394366	ENST00000393081	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000394366	ENST00000433418	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000394366	ENST00000479936	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000451983	ENST00000354273	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000451983	ENST00000354655	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000451983	ENST00000356116	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000451983	ENST00000369410	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000451983	ENST00000393081	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000451983	ENST00000433418	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000451983	ENST00000479936	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000553521	ENST00000354273	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000553521	ENST00000354655	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000553521	ENST00000356116	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000553521	ENST00000369410	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000553521	ENST00000393081	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000553521	ENST00000433418	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000553521	ENST00000479936	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000553548	ENST00000354273	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000553548	ENST00000354655	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000553548	ENST00000356116	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000553548	ENST00000369410	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000553548	ENST00000393081	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000553548	ENST00000433418	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000553548	ENST00000479936	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000553635	ENST00000354273	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000553635	ENST00000354655	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000553635	ENST00000356116	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000553635	ENST00000369410	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000553635	ENST00000393081	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000553635	ENST00000433418	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000553635	ENST00000479936	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000554021	ENST00000354273	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000554021	ENST00000354655	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000554021	ENST00000356116	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000554021	ENST00000369410	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000554021	ENST00000393081	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000554021	ENST00000433418	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000554021	ENST00000479936	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000556587	ENST00000354273	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000556587	ENST00000354655	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000556587	ENST00000356116	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000556587	ENST00000369410	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000556587	ENST00000393081	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000556587	ENST00000433418	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000556587	ENST00000479936	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000557154	ENST00000354273	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000557154	ENST00000354655	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000557154	ENST00000356116	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000557154	ENST00000369410	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000557154	ENST00000393081	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000557154	ENST00000433418	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+
intron-intron	ENST00000557154	ENST00000479936	SRSF5	chr14	70236008	+	ACSL5	chr10	114165753	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for SRSF5-ACSL5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SRSF5-ACSL5

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:70236008/:114165753)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ACSL5 Q9ULC5
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:17681178, PubMed:24269233, PubMed:22633490). ACSL5 may activate fatty acids from exogenous sources for the synthesis of triacylglycerol destined for intracellular storage (By similarity). Utilizes a wide range of saturated fatty acids with a preference for C16-C18 unsaturated fatty acids (By similarity). It was suggested that it may also stimulate fatty acid oxidation (By similarity). At the villus tip of the crypt-villus axis of the small intestine may sensitize epithelial cells to apoptosis specifically triggered by the death ligand TRAIL. May have a role in the survival of glioma cells. {ECO:0000250, ECO:0000269\|PubMed:17681178, ECO:0000269\|PubMed:18806831, ECO:0000269\|PubMed:19459852, ECO:0000269\|PubMed:22633490, ECO:0000269\|PubMed:24269233}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for SRSF5-ACSL5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SRSF5-ACSL5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for SRSF5-ACSL5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SRSF5-ACSL5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source