Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SRSF5-CCT5 (FusionGDB2 ID:86628)

Fusion Gene Summary for SRSF5-CCT5

Fusion gene summary

Fusion gene information	Fusion gene name: SRSF5-CCT5
	Fusion gene ID: 86628
		Hgene	Tgene
	Gene symbol	SRSF5	CCT5
	Gene ID	6430	22948
	Gene name	serine and arginine rich splicing factor 5	chaperonin containing TCP1 subunit 5
	Synonyms	HRS\|SFRS5\|SRP40	CCT-epsilon\|CCTE\|HEL-S-69\|PNAS-102\|TCP-1-epsilon
	Cytomap	14q24.1	5p15.2
	Type of gene	protein-coding	protein-coding
	Description	serine/arginine-rich splicing factor 5SR splicing factor 5delayed-early protein HRSpre-mRNA-splicing factor SRP40splicing factor, arginine/serine-rich 5	T-complex protein 1 subunit epsilonchaperonin containing TCP1, subunit 5 (epsilon)epididymis secretory protein Li 69
	Modification date	20200320	20200313
	UniProtAcc	.	P48643
	Ensembl transtripts involved in fusion gene	ENST00000553521, ENST00000556587, ENST00000394366, ENST00000451983, ENST00000553548, ENST00000553635, ENST00000554021, ENST00000555349, ENST00000557154,	ENST00000503026, ENST00000506600, ENST00000515390, ENST00000515676, ENST00000280326,
Fusion gene scores	* DoF score	12 X 8 X 6=576	58 X 14 X 17=13804
	# samples	11	61
	** MAII score	log2(11/576*10)=-2.38856528791765 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(61/13804*10)=-4.50013332598527 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SRSF5 [Title/Abstract] AND CCT5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SRSF5(70238721)-CCT5(10250033), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across SRSF5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CCT5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	CESC	TCGA-C5-A905-01A	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+

Top

Fusion Gene ORF analysis for SRSF5-CCT5

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000553521	ENST00000503026	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
5CDS-intron	ENST00000553521	ENST00000506600	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
5CDS-intron	ENST00000553521	ENST00000515390	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
5CDS-intron	ENST00000553521	ENST00000515676	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
5CDS-intron	ENST00000556587	ENST00000503026	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
5CDS-intron	ENST00000556587	ENST00000506600	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
5CDS-intron	ENST00000556587	ENST00000515390	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
5CDS-intron	ENST00000556587	ENST00000515676	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
In-frame	ENST00000553521	ENST00000280326	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
In-frame	ENST00000556587	ENST00000280326	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-3CDS	ENST00000394366	ENST00000280326	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-3CDS	ENST00000451983	ENST00000280326	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-3CDS	ENST00000553548	ENST00000280326	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-3CDS	ENST00000553635	ENST00000280326	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-3CDS	ENST00000554021	ENST00000280326	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-3CDS	ENST00000555349	ENST00000280326	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-3CDS	ENST00000557154	ENST00000280326	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000394366	ENST00000503026	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000394366	ENST00000506600	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000394366	ENST00000515390	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000394366	ENST00000515676	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000451983	ENST00000503026	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000451983	ENST00000506600	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000451983	ENST00000515390	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000451983	ENST00000515676	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000553548	ENST00000503026	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000553548	ENST00000506600	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000553548	ENST00000515390	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000553548	ENST00000515676	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000553635	ENST00000503026	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000553635	ENST00000506600	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000553635	ENST00000515390	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000553635	ENST00000515676	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000554021	ENST00000503026	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000554021	ENST00000506600	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000554021	ENST00000515390	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000554021	ENST00000515676	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000555349	ENST00000503026	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000555349	ENST00000506600	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000555349	ENST00000515390	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000555349	ENST00000515676	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000557154	ENST00000503026	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000557154	ENST00000506600	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000557154	ENST00000515390	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+
intron-intron	ENST00000557154	ENST00000515676	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000553521

SRSF5

chr14

70238721

ENST00000280326

CCT5

chr5

10250033

6490

2815

3205

4860

551

ENST00000556587

SRSF5

chr14

70238721

ENST00000280326

CCT5

chr5

10250033

5538

1863

2253

3908

551

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000553521	ENST00000280326	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+	0.000601071	0.99939895
ENST00000556587	ENST00000280326	SRSF5	chr14	70238721	-	CCT5	chr5	10250033	+	0.000503372	0.9994966

Top

Fusion Genomic Features for SRSF5-CCT5

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for SRSF5-CCT5

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:70238721/chr5:10250033)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CCT5 P48643
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269\|PubMed:20080638, ECO:0000269\|PubMed:25467444, ECO:0000305}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SRSF5

chr14:70238721

chr5:10250033

ENST00000553521

182_267

454

273.0

Compositional bias

Note=Arg/Ser-rich (RS domain)

Hgene

SRSF5

chr14:70238721

chr5:10250033

ENST00000553521

78_83

454

273.0

Compositional bias

Note=Gly-rich (hinge region)

Hgene

SRSF5

chr14:70238721

chr5:10250033

ENST00000553521

108_181

454

273.0

Domain

RRM 2

Hgene

SRSF5

chr14:70238721

chr5:10250033

ENST00000553521

4_74

454

273.0

Domain

RRM 1

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SRSF5

chr14:70238721

chr5:10250033

ENST00000394366

182_267

273.0

Compositional bias

Note=Arg/Ser-rich (RS domain)

Hgene

SRSF5

chr14:70238721

chr5:10250033

ENST00000394366

78_83

273.0

Compositional bias

Note=Gly-rich (hinge region)

Hgene

SRSF5

chr14:70238721

chr5:10250033

ENST00000553635

182_267

270.0

Compositional bias

Note=Arg/Ser-rich (RS domain)

Hgene

SRSF5

chr14:70238721

chr5:10250033

ENST00000553635

78_83

270.0

Compositional bias

Note=Gly-rich (hinge region)

Hgene

SRSF5

chr14:70238721

chr5:10250033

ENST00000557154

182_267

273.0

Compositional bias

Note=Arg/Ser-rich (RS domain)

Hgene

SRSF5

chr14:70238721

chr5:10250033

ENST00000557154

78_83

273.0

Compositional bias

Note=Gly-rich (hinge region)

Hgene

SRSF5

chr14:70238721

chr5:10250033

ENST00000394366

108_181

273.0

Domain

RRM 2

Hgene

SRSF5

chr14:70238721

chr5:10250033

ENST00000394366

4_74

273.0

Domain

RRM 1

Hgene

SRSF5

chr14:70238721

chr5:10250033

ENST00000553635

108_181

270.0

Domain

RRM 2

Hgene

SRSF5

chr14:70238721

chr5:10250033

ENST00000553635

4_74

270.0

Domain

RRM 1

Hgene

SRSF5

chr14:70238721

chr5:10250033

ENST00000557154

108_181

273.0

Domain

RRM 2

Hgene

SRSF5

chr14:70238721

chr5:10250033

ENST00000557154

4_74

273.0

Domain

RRM 1

Top

Fusion Gene Sequence for SRSF5-CCT5

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>86628_86628_1_SRSF5-CCT5_SRSF5_chr14_70238721_ENST00000553521_CCT5_chr5_10250033_ENST00000280326_length(transcript)=6490nt_BP=2815nt
GCCGGAGGAAGCGCCACGGGCGGCTCAGACCTGAGGCCGCAAGGGCGCGCCGGGCGGGCAGGGCGGAGGGTCCGATTTCCTCCCTCTGAA
CGGAAAAAAAGCCACTTTCCCTGGGAAGAACTCGAAGAAGTTGGATGTCTGATCTTCACCTTGGATTTGTGGTCTCGGCCCGCGGGCGAC
TCACCCCACCCACCAGGATCCCACGAAGCCGGGCCGGCTCAGCCCGCTGGCGCCATCTAGTGTCGAATGAGGAGGCGGCCCTCTGCGGCT
GGAGGGGACGCTTGGGCGTGTGAAATCTGAACGGAGAGGATTAACCAAATACCATTTGGACTTAAAAGCAGCTTGAGGCCGGGCGCGGTG
GCTCATGCCTGTAATCCCAGCACTTTGGGAGGCCGAGACGGGCCGATCACGAGGTCAGGAGATCGAGACCATCCCGGCTAACACGGTGAA
ACCCCGTCTCTACTAAAAATACAAAAAAATTAGCCGGTGTGGTGGCGGGCGCCTGTAGTCGCAGCTACTCGGGAGGCTGAGGCAGAAGAA
TGGCGTGAACCCGGGAGGCGGAGCCCAGATCGCGCCACTGCACTCCAGCCTGGGCGACAGAGCAAGACTGTCTCAAAAAAAACAACAAAA
AACAGCTTGAAACCTCTTCCAGCCACTCTCCCAGAGTGACGGACATGCAGAAATCTGTATTCCAGCCTCAATTCAAGACAGCCTTCTAGC
TGCAGTCCCATTTTCAACATTTCATCAGTGAAAATCCTTTCATTTAAAAAATACTTCAGTGCCTTAGTCTTCTCACCACAACAAAACCAC
ACAGCTGTGGCATGGTTGAAAAAAGAACTCGAACATCTAGGAGCTCCCTGCTTTGAGGGCAAATTTAAATTGCAAGCAGCAAGAGCTAAG
GAAAGGCCAGGTATTTCTGCAAAGCTAAGTTTCTCCTAATTAGTAATCTTCTGGGTGTCTAAGAAAAACTTTAGATACAAGAAGGGTTGC
CACTTTTCTCAGGAGACTCTTCTGGGAGAGATGATGATGAACCGAACGCCAAGGACTTAGCAGGGGCGAACGACGTCAACAGATGTCCCT
CCAGACTCCGGCACCAGCCGGCCGAGCCCAAACGAGTTCTCGCCCCCGACCCCACCCACCGCGGGAGCAGGGTTCGGTCACTCGCAGTGT
CAGAGAGGCCCACATCCTCCTAAATTTCCGGCCCTCCCAAAACTTCCGTCTTCCCTAGGTCCAACGGGGTGGACCCAAGGCCCAGGGGCG
TCCCCGGAAGTGACGTAGGACGCGCCCTCCATTTTGTGGAGCGCCAGAGCTGCTAAGTGCGTCAGTTGTGGAGTGGCGTAGACGAGTTAA
GTCCTGGTCTGCGTGGAGGTCGACGACTCCGTCGCAGACTACGGACCTGTCTGGGTCTCAGCCGCCAAAGACCCCGTCCGGTAGGAAGTA
CTAGCCGGACATCATGAGTGGCTGTCGGGTATTCATCGGGAGACTAAATCCAGCGGCCAGGGAGAAGGACGTGGAAAGATTCTTCAAGGG
ATATGGACGGATAAGAGATATTGATCTGAAAAGAGGCTTTGGTTTTGTGGAATTTGAGGATCCAAGGGATGCAGATGATGCTGTGTATGA
GCTTGATGGAAAAGAACTCTGTAGTGAAAGGGTTACTATTGAACATGCTAGGGCTCGGTCACGAGGTGGAAGAGGTAGAGGACGATACTC
TGACCGTTTTAGTAGTCGCAGACCTCGAAATGATAGACGAAATGCTCCACCTGTAAGAACAGAAAATCGTCTTATAGTTGAGAATTTATC
CTCAAGAGTCAGCTGGCAGGATCTCAAAGATTTCATGAGACAAGCTGGGGAAGTAACGTTTGCGGATGCACACCGACCTAAATTAAATGA
AGGGGTGGTTGAGTTTGCCTCTTATGGTGACTTAAAGAATGCTATTGAAAAACTTTCTGGAAAGGAAATAAATGGGAGAAAAATAAAATT
AATTGAAGGCAGCAAAAGGCACAGTAGGTCAAGAAGCAGGTCTCGATCCCGGACCAGAAGTTCCTCTAGGTCTCGTAGCCGATCCCGTTC
CCGTAGTCGCAAATCTTACAGCCGGTCAAGAAGCAGGAGCAGGAGCCGGAGCCGGAGCAAGTCCCGTTCTGTTAGTAGGTCTCCCGTGCC
TGAGAAGAGCCAGAAACGTGGTTCTTCAAGTAGATCTAAGTCTCCAGCATCTGTGGATCGCCAGAGGTCCCGGTCCCGATCAAGGTCCAG
ATCAGTTGACAGTGGCAATTAAACTGTAAATAACTTGCCCTGGGGGCCTTTTTTTAAAAAACAAAAACCACAAAAATTCCCAAACCATAC
TTGCTAAAAATTCTGGTAAGTATGTGCTTTTCTGTGGGGGTGGGATTTGGAAGGGGGGTTGGGTTGGGCTGGATATCTTTGTAGATGTGG
ACCACCAAGGGGTTGTTGAAAACTAATTGTATTAAATGTCTTTTGATAAGCCTTCTGCTCACATTTTTGTGAATGTCTGAAGTATATAGT
TTGTGTATATTGACAGAGCTCTTTTATAACTAAAGCAAATTTAATTTTTTTGTACTAGAAAAAAATTTGAACATTTTAGTTCTTGGTTAT
AAAAATGTTAATTCAGAATTAGTTTAATGCCTTAATTAAACTAATTAATAGCTTTGGACACTTAAAAGAGCTCTAAATTTGCTTGTACAT
AAAGGCTTAATTTGTTTTCCTTGTTAGGGTCAAGGGTGTCCTCCACTCTTTAACAGCTGCTGGACAGACACATTAGAGCAGCTGTTTGTT
ATTGATAATAAAATATTATAAAACTAAAAAAAAAAAAAACCGGAAATGGGTCCTACCATCTTCTCGGAGCCGGAGTGCGAAGAAATAAAG
AAATAGTGCTTTAAGTCAATGAATTCCTCCTTGGGACCCACTATCGAGAAACTATCAGTGGTAACGTTTTAAAAAATGACAAATTCAATC
TGCTCTTGACTTGTGTGTCCTAAGATTTCCACTAAGTGTCTTCAAACCTCCCCCTCCCCGGCTTCCTGGATAATAGAAGTTCCCGAAGGC
CGCCGATTCCAGAAGATACTGTCTGGCGTGAAATTAGTCTCAGTAGAAACATAAGTCCCGCGCGTCTTGTGCTGCGCGTGCGCAAGCTTT
TGGGCCCTCCCGAGAAAGGGAAGTGCATTCTCGCTTCCGTAGCGGTCTCCGCCGGTTGGGGGGAAGTAATTCCGGTTGTTGCACCATGGC
GTCCATGGGGACCCTCGCCTTCGATGAATATGGGCGCCCTTTCCTCATCATCAAGGATCAGGACCGCAAGTCCCGTCTTATGGGACTTGA
GGCCCTCAAGTCTCATATAATGGCAGCAAAGGCTGTAGCAAATACAATGAGAACATCACTTGGACCAAATGGGCTTGATAAGATGATGGT
GGATAAGGATGGAGATGTGACTGTAACTAATGATGGGGCCACCATCTTAAGCATGATGGATGTTGATCATCAGATTGCCAAGCTGATGGT
GGAACTGTCCAAGTCTCAGGATGATGAAATTGGAGATGGAACCACAGGAGTGGTTGTCCTGGCTGGTGCCTTGTTAGAAGAAGCGGAGCA
ATTGCTAGACCGAGGCATTCACCCAATCAGAATAGCCGATGGCTATGAGCAGGCTGCTCGTGTTGCTATTGAACACCTGGACAAGATCAG
CGATAGCGTCCTTGTTGACATAAAGGACACCGAACCCCTGATTCAGACAGCAAAAACCACGCTGGGCTCCAAAGTGGTCAACAGTTGTCA
CCGACAGATGGCTGAGATTGCTGTGAATGCCGTCCTCACTGTAGCAGATATGGAGCGGAGAGACGTTGACTTTGAGCTTATCAAAGTAGA
AGGCAAAGTGGGCGGCAGGCTGGAGGACACTAAACTGATTAAGGGCGTGATTGTGGACAAGGATTTCAGTCACCCACAGATGCCAAAAAA
AGTGGAAGATGCGAAGATTGCAATTCTCACATGTCCATTTGAACCACCCAAACCAAAAACAAAGCATAAGCTGGATGTGACCTCTGTCGA
AGATTATAAAGCCCTTCAGAAATACGAAAAGGAGAAATTTGAAGAGATGATTCAACAAATTAAAGAGACTGGTGCTAACCTAGCAATTTG
TCAGTGGGGCTTTGATGATGAAGCAAATCACTTACTTCTTCAGAACAACTTGCCTGCGGTTCGCTGGGTAGGAGGACCTGAAATTGAGCT
GATTGCCATCGCAACAGGAGGGCGGATCGTCCCCAGGTTCTCAGAGCTCACAGCCGAGAAGCTGGGCTTTGCTGGTCTTGTACAGGAGAT
CTCATTTGGGACAACTAAGGATAAAATGCTGGTCATCGAGCAGTGTAAGAACTCCAGAGCTGTAACCATTTTTATTAGAGGAGGAAATAA
GATGATCATTGAGGAGGCGAAACGATCCCTTCACGATGCTTTGTGTGTCATCCGGAACCTCATCCGCGATAATCGTGTGGTGTATGGAGG
AGGGGCTGCTGAGATATCCTGTGCCCTGGCAGTTAGCCAAGAGGCGGATAAGTGCCCCACCTTAGAACAGTATGCCATGAGAGCGTTTGC
CGACGCACTGGAGGTCATCCCCATGGCCCTCTCTGAAAACAGTGGCATGAATCCCATCCAGACTATGACCGAAGTCCGAGCCAGACAGGT
GAAGGAGATGAACCCTGCTCTTGGCATCGACTGTTTGCACAAGGGGACAAATGATATGAAGCAACAGCATGTCATAGAAACCTTGATTGG
CAAAAAGCAACAGATATCTCTTGCAACACAAATGGTTAGAATGATTTTGAAGATTGATGACATTCGTAAGCCTGGAGAATCTGAAGAATG
AAGACATTGAGAAAACTATGTAGCAAGATCCACTTCTGTGATTAAGTAAATGGATGTCTCGTGATGCATCTACAGTTATTTATTGTTACA
TCCTTTTCCAGACACTGTAGATGCTATAATAAAAATAGCTGTTTGGTAACCATAGTTTCACTTGTTCAAAGCTGTGTAATCGTGGGGGTA
CCATCTCAACTGCTTTTGTATTCATTGTATTAAAAGAATCTGTTTAAACAACCTTTATCTTCTCTTCGGGTTTAAGAAACGTTTATTGTA
ACAGTAATTAAATGCTGCCTTAATTGAAGGGGTTTGGGTGGATTTTTTTTTCTCAAAATAAGCTGTAGGGACTATTTTAACAGCTTAAAC
AGGAGCTCTCAAGATGCACTTTCATATTGAGAGGAATATGGGCTTGATCCTCTTCCTATCTAAATGGGTGGGCCATTTGATTGTAGAGGG
TCCACCACAGAATTATGGGATGCCTTAAGTGCTGTTACTAGGTTGCTCACAGCCTAACCTGGCGTGTTGTTTAGGGCTGATGGAGACCCA
TGTGAGCCTTTGCTTTCCTCTGGCCCCGGCCCCACCCTGAACACAGCTCATACACAGAATCAGGACCAGCATGTGCAGAGCTGGCCACCA
GCACAGGCTTAGGGCAGTTCAGAACCCACTTGTTTCCCTATCAGAGGGACACAGTGAAGTGGAGGTTAAAGTAAATTACAGGAAATAAGG
GAGAAATCTTGCAGTTACCATGTTCAGATAGAGTGACTGAAATTAATTGTACTTACTAAAGTATTAACTAGCTAACAGTGATGGGCCAAG
ACGCTCCGAGAACTCTACCGGGATTGTCTGTTCTGACAACCCAGTGAGGCAGATACACTTTCTTACTGCTCACATCTTACAGGTGAGTAC
TCATAATTGGCCAGCATCTCACCACCAGCAAGTAGTAGGGCCAGGTCAATCCCAGGCAGTCTGACCCCAGAGTGGCCCAGCTCATCCCCT
ACTCTGTTATTTGCTTGTTAATGATTCTCTAGATTTTCTAAAATAATGTTTCTTAGCATTGTGATGATAAAGCTCATGATGAACTTTATC
ACTAGTTATGCCACCTTAACTAGTCAGATTTCCTAGAATTAGGAAATGGTGACTCTTGTCTAAATTTGGTTAAGTGATGAATTTGGGTTA
CCGTCTCATGTGAACCTGGAGATTCACCAGTCTTAACTTTTGGGTCATTGTGTTTTCTCTACATTCATGCATTGGATGTTTTGCTAAATA
ACTCCTGTGGATTTAGGAATGTGTGCTAATAGCAATCTTCCTAATTTTCATGTTTATATGGAACTATGCAGTTGAGTATTGAAAGCTTTA
AACTGAGTTTATTTACAAGGACTGAGTCTAGCCTACAGAGAACATACAGCAGCCTTCTTTGGACCACAGTCTTATCCGAGGGGTCTGTGG
TTGTATCAGAAGAGCCACTAAACCAATCCCCCTTTCCAAAATTGAACCTCACAGACGTTCCTGTTTTTTGTGATTGAGAAACTGGTCAAT
GAACAGGAAGACTTAGAGATGTTTCACAAGCCTTTGATTTTTGTTTCATTTATTTGTAATAAACCTCTTCCACGTGATGTCTTTTATTTT

>86628_86628_1_SRSF5-CCT5_SRSF5_chr14_70238721_ENST00000553521_CCT5_chr5_10250033_ENST00000280326_length(amino acids)=551AA_BP=
MGGSNSGCCTMASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSM
MDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAK
TTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKP
KTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTA
EKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKC
PTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKI

--------------------------------------------------------------
>86628_86628_2_SRSF5-CCT5_SRSF5_chr14_70238721_ENST00000556587_CCT5_chr5_10250033_ENST00000280326_length(transcript)=5538nt_BP=1863nt
GCGTGGAGGTCGACGACTCCGTCGCAGACTACGGACCTGTCTGGGTCTCAGCCGCCAAAGACCCCGTCCGGTAGGTGAGTGGCTCACTTT
GAGGGCAAGCCTTCTCGGATCGAGGCTTCTTCATGGCCGCTCAGATCGTGAGCGGCCGGGGCTGCTCTCTTTGCGGAGGATGGCGTCTAA
TGAGCGCAGTTGATTCGAGGAAGTACTAGCCGGACATCATGAGTGGCTGTCGGGTATTCATCGGGAGACTAAATCCAGCGGCCAGGGAGA
AGGACGTGGAAAGATTCTTCAAGGGATATGGACGGATAAGAGATATTGATCTGAAAAGAGGCTTTGGTTTTGTGGAATTTGAGGATCCAA
GGGATGCAGATGATGCTGTGTATGAGCTTGATGGAAAAGAACTCTGTAGTGAAAGGGTTACTATTGAACATGCTAGGGCTCGGTCACGAG
GTGGAAGAGGTAGAGGACGATACTCTGACCGTTTTAGTAGTCGCAGACCTCGAAATGATAGACGGTATGTGAAGGGTGGATGGCTGCATT
GAACAATTATTGTAGGGGTAGCATTTAAGATTCAGGAGTCATTAGCAGTGATGATTTTGGGTCCTGCCGTATAATCTGTTCTTCTATTCC
CACGTTAGCCAGTTGTTCTTGATGAATCTATATGAGTCATAGAACACAAATCTATTGACGGAAGTCATTAGAATGGCTTGTGATATCTGA
TGGCTTGAACTTGCCCACAGTTGAACACAAGTGCTGTCATTGCATTTCTTCCATTGTGAATACGAATTTTCTTCCTCAGAAATGCTCCAC
CTGTAAGAACAGAAAATCGTCTTATAGTTGAGAATTTATCCTCAAGAGTCAGCTGGCAGGATCTCAAAGATTTCATGAGACAAGCTGGGG
AAGTAACGTTTGCGGATGCACACCGACCTAAATTAAATGAAGGGGTGGTTGAGTTTGCCTCTTATGGTGACTTAAAGAATGCTATTGAAA
AACTTTCTGGAAAGGAAATAAATGGGAGAAAAATAAAATTAATTGAAGGCAGCAAAAGGCACAGGTCAAGAAGCAGGTCTCGATCCCGGA
CCAGAAGTTCCTCTAGGTCTCGTAGCCGATCCCGTTCCCGTAGTCGCAAATCTTACAGCCGGTCAAGAAGCAGGAGCAGGAGCCGGAGCC
GGAGCAAGTCCCGTTCTGTTAGTAGGTCTCCCGTGCCTGAGAAGAGCCAGAAACGTGGTTCTTCAAGTAGATCTAAGTCTCCAGCATCTG
TGGATCGCCAGAGGTCCCGGTCCCGATCAAGGTCCAGATCAGTTGACAGTGGCAATTAAACTGTAAATAACTTGCCCTGGGGGCCTTTTT
TTAAAAAACAAAAACCACAAAAATTCCCAAACCATACTTGCTAAAAATTCTGGTAAGTATGTGCTTTTCTGTGGGGGTGGGATTTGGAAG
GGGGGTTGGGTTGGGCTGGATATCTTTGTAGATGTGGACCACCAAGGGGTTGTTGAAAACTAATTGTATTAAATGTCTTTTGATAAGCCT
TCTGCTCACATTTTTGTGAATGTCTGAAGTATATAGTTTGTGTATATTGACAGAGCTCTTTTATAACTAAAGCAAATTTAATTTTTTTGT
ACTAGAAAAAAATTTGAACATTTTAGTTCTTGGTTATAAAAATGTTAATTCAGAATTAGTTTAATGCCTTAATTAAACTAATTAATAGCT
TTGGACACTTAAAAGAGCTCTAAATTTGCTTGTACATAAAGGCTTAATTTGTTTTCCTTGTTAGGGTCAAGGGTGTCCTCCACTCTTTAA
CAGCTGCTGGACAGACACATTAGAGCAGCTGTTTGTTATTGATAATAAAATATTATAAAACTAAAAAAAAAAAAAAACCGGAAATGGGTC
CTACCATCTTCTCGGAGCCGGAGTGCGAAGAAATAAAGAAATAGTGCTTTAAGTCAATGAATTCCTCCTTGGGACCCACTATCGAGAAAC
TATCAGTGGTAACGTTTTAAAAAATGACAAATTCAATCTGCTCTTGACTTGTGTGTCCTAAGATTTCCACTAAGTGTCTTCAAACCTCCC
CCTCCCCGGCTTCCTGGATAATAGAAGTTCCCGAAGGCCGCCGATTCCAGAAGATACTGTCTGGCGTGAAATTAGTCTCAGTAGAAACAT
AAGTCCCGCGCGTCTTGTGCTGCGCGTGCGCAAGCTTTTGGGCCCTCCCGAGAAAGGGAAGTGCATTCTCGCTTCCGTAGCGGTCTCCGC
CGGTTGGGGGGAAGTAATTCCGGTTGTTGCACCATGGCGTCCATGGGGACCCTCGCCTTCGATGAATATGGGCGCCCTTTCCTCATCATC
AAGGATCAGGACCGCAAGTCCCGTCTTATGGGACTTGAGGCCCTCAAGTCTCATATAATGGCAGCAAAGGCTGTAGCAAATACAATGAGA
ACATCACTTGGACCAAATGGGCTTGATAAGATGATGGTGGATAAGGATGGAGATGTGACTGTAACTAATGATGGGGCCACCATCTTAAGC
ATGATGGATGTTGATCATCAGATTGCCAAGCTGATGGTGGAACTGTCCAAGTCTCAGGATGATGAAATTGGAGATGGAACCACAGGAGTG
GTTGTCCTGGCTGGTGCCTTGTTAGAAGAAGCGGAGCAATTGCTAGACCGAGGCATTCACCCAATCAGAATAGCCGATGGCTATGAGCAG
GCTGCTCGTGTTGCTATTGAACACCTGGACAAGATCAGCGATAGCGTCCTTGTTGACATAAAGGACACCGAACCCCTGATTCAGACAGCA
AAAACCACGCTGGGCTCCAAAGTGGTCAACAGTTGTCACCGACAGATGGCTGAGATTGCTGTGAATGCCGTCCTCACTGTAGCAGATATG
GAGCGGAGAGACGTTGACTTTGAGCTTATCAAAGTAGAAGGCAAAGTGGGCGGCAGGCTGGAGGACACTAAACTGATTAAGGGCGTGATT
GTGGACAAGGATTTCAGTCACCCACAGATGCCAAAAAAAGTGGAAGATGCGAAGATTGCAATTCTCACATGTCCATTTGAACCACCCAAA
CCAAAAACAAAGCATAAGCTGGATGTGACCTCTGTCGAAGATTATAAAGCCCTTCAGAAATACGAAAAGGAGAAATTTGAAGAGATGATT
CAACAAATTAAAGAGACTGGTGCTAACCTAGCAATTTGTCAGTGGGGCTTTGATGATGAAGCAAATCACTTACTTCTTCAGAACAACTTG
CCTGCGGTTCGCTGGGTAGGAGGACCTGAAATTGAGCTGATTGCCATCGCAACAGGAGGGCGGATCGTCCCCAGGTTCTCAGAGCTCACA
GCCGAGAAGCTGGGCTTTGCTGGTCTTGTACAGGAGATCTCATTTGGGACAACTAAGGATAAAATGCTGGTCATCGAGCAGTGTAAGAAC
TCCAGAGCTGTAACCATTTTTATTAGAGGAGGAAATAAGATGATCATTGAGGAGGCGAAACGATCCCTTCACGATGCTTTGTGTGTCATC
CGGAACCTCATCCGCGATAATCGTGTGGTGTATGGAGGAGGGGCTGCTGAGATATCCTGTGCCCTGGCAGTTAGCCAAGAGGCGGATAAG
TGCCCCACCTTAGAACAGTATGCCATGAGAGCGTTTGCCGACGCACTGGAGGTCATCCCCATGGCCCTCTCTGAAAACAGTGGCATGAAT
CCCATCCAGACTATGACCGAAGTCCGAGCCAGACAGGTGAAGGAGATGAACCCTGCTCTTGGCATCGACTGTTTGCACAAGGGGACAAAT
GATATGAAGCAACAGCATGTCATAGAAACCTTGATTGGCAAAAAGCAACAGATATCTCTTGCAACACAAATGGTTAGAATGATTTTGAAG
ATTGATGACATTCGTAAGCCTGGAGAATCTGAAGAATGAAGACATTGAGAAAACTATGTAGCAAGATCCACTTCTGTGATTAAGTAAATG
GATGTCTCGTGATGCATCTACAGTTATTTATTGTTACATCCTTTTCCAGACACTGTAGATGCTATAATAAAAATAGCTGTTTGGTAACCA
TAGTTTCACTTGTTCAAAGCTGTGTAATCGTGGGGGTACCATCTCAACTGCTTTTGTATTCATTGTATTAAAAGAATCTGTTTAAACAAC
CTTTATCTTCTCTTCGGGTTTAAGAAACGTTTATTGTAACAGTAATTAAATGCTGCCTTAATTGAAGGGGTTTGGGTGGATTTTTTTTTC
TCAAAATAAGCTGTAGGGACTATTTTAACAGCTTAAACAGGAGCTCTCAAGATGCACTTTCATATTGAGAGGAATATGGGCTTGATCCTC
TTCCTATCTAAATGGGTGGGCCATTTGATTGTAGAGGGTCCACCACAGAATTATGGGATGCCTTAAGTGCTGTTACTAGGTTGCTCACAG
CCTAACCTGGCGTGTTGTTTAGGGCTGATGGAGACCCATGTGAGCCTTTGCTTTCCTCTGGCCCCGGCCCCACCCTGAACACAGCTCATA
CACAGAATCAGGACCAGCATGTGCAGAGCTGGCCACCAGCACAGGCTTAGGGCAGTTCAGAACCCACTTGTTTCCCTATCAGAGGGACAC
AGTGAAGTGGAGGTTAAAGTAAATTACAGGAAATAAGGGAGAAATCTTGCAGTTACCATGTTCAGATAGAGTGACTGAAATTAATTGTAC
TTACTAAAGTATTAACTAGCTAACAGTGATGGGCCAAGACGCTCCGAGAACTCTACCGGGATTGTCTGTTCTGACAACCCAGTGAGGCAG
ATACACTTTCTTACTGCTCACATCTTACAGGTGAGTACTCATAATTGGCCAGCATCTCACCACCAGCAAGTAGTAGGGCCAGGTCAATCC
CAGGCAGTCTGACCCCAGAGTGGCCCAGCTCATCCCCTACTCTGTTATTTGCTTGTTAATGATTCTCTAGATTTTCTAAAATAATGTTTC
TTAGCATTGTGATGATAAAGCTCATGATGAACTTTATCACTAGTTATGCCACCTTAACTAGTCAGATTTCCTAGAATTAGGAAATGGTGA
CTCTTGTCTAAATTTGGTTAAGTGATGAATTTGGGTTACCGTCTCATGTGAACCTGGAGATTCACCAGTCTTAACTTTTGGGTCATTGTG
TTTTCTCTACATTCATGCATTGGATGTTTTGCTAAATAACTCCTGTGGATTTAGGAATGTGTGCTAATAGCAATCTTCCTAATTTTCATG
TTTATATGGAACTATGCAGTTGAGTATTGAAAGCTTTAAACTGAGTTTATTTACAAGGACTGAGTCTAGCCTACAGAGAACATACAGCAG
CCTTCTTTGGACCACAGTCTTATCCGAGGGGTCTGTGGTTGTATCAGAAGAGCCACTAAACCAATCCCCCTTTCCAAAATTGAACCTCAC
AGACGTTCCTGTTTTTTGTGATTGAGAAACTGGTCAATGAACAGGAAGACTTAGAGATGTTTCACAAGCCTTTGATTTTTGTTTCATTTA

>86628_86628_2_SRSF5-CCT5_SRSF5_chr14_70238721_ENST00000556587_CCT5_chr5_10250033_ENST00000280326_length(amino acids)=551AA_BP=
MGGSNSGCCTMASMGTLAFDEYGRPFLIIKDQDRKSRLMGLEALKSHIMAAKAVANTMRTSLGPNGLDKMMVDKDGDVTVTNDGATILSM
MDVDHQIAKLMVELSKSQDDEIGDGTTGVVVLAGALLEEAEQLLDRGIHPIRIADGYEQAARVAIEHLDKISDSVLVDIKDTEPLIQTAK
TTLGSKVVNSCHRQMAEIAVNAVLTVADMERRDVDFELIKVEGKVGGRLEDTKLIKGVIVDKDFSHPQMPKKVEDAKIAILTCPFEPPKP
KTKHKLDVTSVEDYKALQKYEKEKFEEMIQQIKETGANLAICQWGFDDEANHLLLQNNLPAVRWVGGPEIELIAIATGGRIVPRFSELTA
EKLGFAGLVQEISFGTTKDKMLVIEQCKNSRAVTIFIRGGNKMIIEEAKRSLHDALCVIRNLIRDNRVVYGGGAAEISCALAVSQEADKC
PTLEQYAMRAFADALEVIPMALSENSGMNPIQTMTEVRARQVKEMNPALGIDCLHKGTNDMKQQHVIETLIGKKQQISLATQMVRMILKI

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SRSF5-CCT5

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SRSF5-CCT5

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for SRSF5-CCT5

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source