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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SS18-DOCK2 (FusionGDB2 ID:86659)

Fusion Gene Summary for SS18-DOCK2

check button Fusion gene summary
Fusion gene informationFusion gene name: SS18-DOCK2
Fusion gene ID: 86659
HgeneTgene
Gene symbol

SS18

DOCK2

Gene ID

6760

1794

Gene nameSS18 subunit of BAF chromatin remodeling complexdedicator of cytokinesis 2
SynonymsSSXT|SYTIMD40
Cytomap

18q11.2

5q35.1

Type of geneprotein-codingprotein-coding
Descriptionprotein SSXTSS18, nBAF chromatin remodeling complex subunitsynovial sarcoma translocated to X chromosome proteinsynovial sarcoma translocation, chromosome 18synovial sarcoma, translocated to X chromosomededicator of cytokinesis protein 2dedicator of cyto-kinesis 2
Modification date2020032920200313
UniProtAcc.

Q92608

Ensembl transtripts involved in fusion geneENST00000269137, ENST00000415083, 
ENST00000539849, ENST00000542420, 
ENST00000542743, ENST00000545952, 
ENST00000585241, 		ENST00000523351, 
ENST00000520908, ENST00000540750, 
ENST00000256935, 
Fusion gene scores* DoF score24 X 33 X 8=633613 X 12 X 8=1248
# samples 3815
** MAII scorelog2(38/6336*10)=-4.05950101174866
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1248*10)=-3.05658352836637
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SS18 [Title/Abstract] AND DOCK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSS18(23612363)-DOCK2(169267761), # samples:3
Anticipated loss of major functional domain due to fusion event.SS18-DOCK2 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
SS18-DOCK2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSS18

GO:0045944

positive regulation of transcription by RNA polymerase II

15919756


check buttonFusion gene breakpoints across SS18 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DOCK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HC-8265-01ASS18chr18

23612363

-DOCK2chr5

169267761

+
ChimerDB4PRADTCGA-HC-8265SS18chr18

23612363

-DOCK2chr5

169267761

+


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Fusion Gene ORF analysis for SS18-DOCK2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000269137ENST00000523351SS18chr18

23612363

-DOCK2chr5

169267761

+
5CDS-3UTRENST00000415083ENST00000523351SS18chr18

23612363

-DOCK2chr5

169267761

+
5CDS-3UTRENST00000539849ENST00000523351SS18chr18

23612363

-DOCK2chr5

169267761

+
5CDS-3UTRENST00000542420ENST00000523351SS18chr18

23612363

-DOCK2chr5

169267761

+
5CDS-3UTRENST00000542743ENST00000523351SS18chr18

23612363

-DOCK2chr5

169267761

+
5CDS-3UTRENST00000545952ENST00000523351SS18chr18

23612363

-DOCK2chr5

169267761

+
5CDS-5UTRENST00000269137ENST00000520908SS18chr18

23612363

-DOCK2chr5

169267761

+
5CDS-5UTRENST00000269137ENST00000540750SS18chr18

23612363

-DOCK2chr5

169267761

+
5CDS-5UTRENST00000415083ENST00000520908SS18chr18

23612363

-DOCK2chr5

169267761

+
5CDS-5UTRENST00000415083ENST00000540750SS18chr18

23612363

-DOCK2chr5

169267761

+
5CDS-5UTRENST00000539849ENST00000520908SS18chr18

23612363

-DOCK2chr5

169267761

+
5CDS-5UTRENST00000539849ENST00000540750SS18chr18

23612363

-DOCK2chr5

169267761

+
5CDS-5UTRENST00000542420ENST00000520908SS18chr18

23612363

-DOCK2chr5

169267761

+
5CDS-5UTRENST00000542420ENST00000540750SS18chr18

23612363

-DOCK2chr5

169267761

+
5CDS-5UTRENST00000542743ENST00000520908SS18chr18

23612363

-DOCK2chr5

169267761

+
5CDS-5UTRENST00000542743ENST00000540750SS18chr18

23612363

-DOCK2chr5

169267761

+
5CDS-5UTRENST00000545952ENST00000520908SS18chr18

23612363

-DOCK2chr5

169267761

+
5CDS-5UTRENST00000545952ENST00000540750SS18chr18

23612363

-DOCK2chr5

169267761

+
Frame-shiftENST00000539849ENST00000256935SS18chr18

23612363

-DOCK2chr5

169267761

+
Frame-shiftENST00000542420ENST00000256935SS18chr18

23612363

-DOCK2chr5

169267761

+
Frame-shiftENST00000542743ENST00000256935SS18chr18

23612363

-DOCK2chr5

169267761

+
In-frameENST00000269137ENST00000256935SS18chr18

23612363

-DOCK2chr5

169267761

+
In-frameENST00000415083ENST00000256935SS18chr18

23612363

-DOCK2chr5

169267761

+
In-frameENST00000545952ENST00000256935SS18chr18

23612363

-DOCK2chr5

169267761

+
intron-3CDSENST00000585241ENST00000256935SS18chr18

23612363

-DOCK2chr5

169267761

+
intron-3UTRENST00000585241ENST00000523351SS18chr18

23612363

-DOCK2chr5

169267761

+
intron-5UTRENST00000585241ENST00000520908SS18chr18

23612363

-DOCK2chr5

169267761

+
intron-5UTRENST00000585241ENST00000540750SS18chr18

23612363

-DOCK2chr5

169267761

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000415083SS18chr1823612363-ENST00000256935DOCK2chr5169267761+460012865640751339
ENST00000269137SS18chr1823612363-ENST00000256935DOCK2chr5169267761+4783146916142581365
ENST00000545952SS18chr1823612363-ENST00000256935DOCK2chr5169267761+4598128430340731256

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000415083ENST00000256935SS18chr1823612363-DOCK2chr5169267761+0.0035430240.9964569
ENST00000269137ENST00000256935SS18chr1823612363-DOCK2chr5169267761+0.0039976210.9960024
ENST00000545952ENST00000256935SS18chr1823612363-DOCK2chr5169267761+0.0040802980.9959197

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Fusion Genomic Features for SS18-DOCK2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SS18chr1823612362-DOCK2chr5169267760+1.50E-081
SS18chr1823612362-DOCK2chr5169267760+1.50E-081
SS18chr1823612362-DOCK2chr5169267760+1.50E-081
SS18chr1823612362-DOCK2chr5169267760+1.50E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SS18-DOCK2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:23612363/chr5:169267761)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DOCK2

Q92608

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2. {ECO:0000269|PubMed:21613211}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSS18chr18:23612363chr5:169267761ENST00000269137-91095_99379388.0Compositional biasNote=Poly-Pro
HgeneSS18chr18:23612363chr5:169267761ENST00000415083-101195_99410419.0Compositional biasNote=Poly-Pro
HgeneSS18chr18:23612363chr5:169267761ENST00000269137-910374_377379388.0MotifSH2-binding
HgeneSS18chr18:23612363chr5:169267761ENST00000269137-91050_53379388.0MotifSH2-binding
HgeneSS18chr18:23612363chr5:169267761ENST00000415083-1011374_377410419.0MotifSH2-binding
HgeneSS18chr18:23612363chr5:169267761ENST00000415083-1011392_401410419.0MotifSH3-binding
HgeneSS18chr18:23612363chr5:169267761ENST00000415083-101150_53410419.0MotifSH2-binding
HgeneSS18chr18:23612363chr5:169267761ENST00000269137-9102_186379388.0RegionNote=Transcriptional activation
HgeneSS18chr18:23612363chr5:169267761ENST00000269137-910344_369379388.0RegionNote=2 X 13 AA imperfect tandem repeats
HgeneSS18chr18:23612363chr5:169267761ENST00000415083-10112_186410419.0RegionNote=Transcriptional activation
HgeneSS18chr18:23612363chr5:169267761ENST00000415083-1011344_369410419.0RegionNote=2 X 13 AA imperfect tandem repeats
HgeneSS18chr18:23612363chr5:169267761ENST00000269137-910344_356379388.0RepeatNote=1
HgeneSS18chr18:23612363chr5:169267761ENST00000269137-910357_369379388.0RepeatNote=2
HgeneSS18chr18:23612363chr5:169267761ENST00000415083-1011344_356410419.0RepeatNote=1
HgeneSS18chr18:23612363chr5:169267761ENST00000415083-1011357_369410419.0RepeatNote=2
TgeneDOCK2chr18:23612363chr5:169267761ENST0000025693525521211_16229011831.0DomainDOCKER

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSS18chr18:23612363chr5:169267761ENST00000269137-910175_418379388.0Compositional biasNote=Gln-rich
HgeneSS18chr18:23612363chr5:169267761ENST00000415083-1011175_418410419.0Compositional biasNote=Gln-rich
HgeneSS18chr18:23612363chr5:169267761ENST00000269137-910392_401379388.0MotifSH3-binding
HgeneSS18chr18:23612363chr5:169267761ENST00000269137-910413_416379388.0MotifSH2-binding
HgeneSS18chr18:23612363chr5:169267761ENST00000415083-1011413_416410419.0MotifSH2-binding
TgeneDOCK2chr18:23612363chr5:169267761ENST000002569352552423_6079011831.0DomainC2 DOCK-type
TgeneDOCK2chr18:23612363chr5:169267761ENST0000025693525528_699011831.0DomainSH3


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Fusion Gene Sequence for SS18-DOCK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>86659_86659_1_SS18-DOCK2_SS18_chr18_23612363_ENST00000269137_DOCK2_chr5_169267761_ENST00000256935_length(transcript)=4783nt_BP=1469nt
TTTCCTGAATCGCTGAAGCGGAGGGAGGACTAGGGCGCGACTCTACCATTAGCGCAAAGGGCCAGGGGGTGCCCATAAGGAGAGCTCGGG
GGATGCAGGGACGGTCAAGAAAGTTCGGCCAGGGCTAGGGGTCCCCCAGAGTGCGCAGAAGCGAGACATCCCTGGCCAGAGTGCCTCCTT
CAGGCCTGCCCCGCCGCCCGTCCGCTTGGCCCCGGAGCATCCCCCCTCCCCGCATTCCCGAGGTGGTTCAGCCCGAGAGGCCGGCGTCTC
TCCCCCAGTTTGCCGTTCACCCGGAGCGCTCGGGACTTGCCGATAGTGGTGACGGCGGCAACATGTCTGTGGCTTTCGCGGCCCCGAGGC
AGCGAGGCAAGGGGGAGATCACTCCCGCTGCGATTCAGAAGATGTTGGATGACAATAACCATCTTATTCAGTGTATAATGGACTCTCAGA
ATAAAGGAAAGACCTCAGAGTGTTCTCAGTATCAGCAGATGTTGCACACAAACTTGGTATACCTTGCTACAATAGCAGATTCTAATCAAA
ATATGCAGTCTCTTTTACCAGCACCACCCACACAGAATATGCCTATGGGTCCTGGAGGGATGAATCAGAGCGGCCCTCCCCCACCTCCAC
GCTCTCACAACATGCCTTCAGATGGAATGGTAGGTGGGGGTCCTCCTGCACCGCACATGCAGAACCAGATGAACGGCCAGATGCCTGGGC
CTAACCATATGCCTATGCAGGGACCTGGACCCAATCAACTCAATATGACAAACAGTTCCATGAATATGCCTTCAAGTAGCCATGGATCCA
TGGGAGGTTACAACCATTCTGTGCCATCATCACAGAGCATGCCAGTACAGAATCAGATGACAATGAGTCAGGGACAACCAATGGGAAACT
ATGGTCCCAGACCAAATATGAGTATGCAGCCAAACCAAGGTCCAATGATGCATCAGCAGCCTCCTTCTCAGCAATACAATATGCCACAGG
GAGGCGGACAGCATTACCAAGGACAGCAGCCACCTATGGGAATGATGGGTCAAGTTAACCAAGGCAATCATATGATGGGTCAGAGACAGA
TTCCTCCCTATAGACCTCCTCAACAGGGCCCACCACAGCAGTACTCAGGCCAGGAAGACTATTACGGGGACCAATACAGTCATGGTGGAC
AAGGTCCTCCAGAAGGCATGAACCAGCAATATTACCCTGATGGAAATTCACAGTATGGCCAACAGCAAGATGCATACCAGGGACCACCTC
CACAACAGGGATATCCACCCCAGCAGCAGCAGTACCCAGGGCAGCAAGGTTACCCAGGACAGCAGCAGGGCTACGGTCCTTCACAGGGTG
GTCCAGGTCCTCAGTATCCTAACTACCCACAGGGACAAGGTCAGCAGTATGGAGGATATAGACCAACACAGCCTGGACCACCACAGCCAC
CCCAGCAGAGGCCTTATGGATATGACCAGGCCTTCACCTACCACCATATCCAGGAGATCATGGTCCAGCTGCTGCGGACAGTGAACCGGA
CAGTCATCACCATGGGCCGGGATCACATTCTGATTAGTCACTTTGTGGCATGTATGACAGCCATCTTAAACCAGATGGGTGACCAGCACT
ACTCCTTCTACATTGAGACCTTCCAGACCAGCTCTGAACTTGTGGACTTCTTGATGGAGACCTTCATCATGTTCAAGGACCTCATTGGAA
AGAACGTGTACCCTGGAGACTGGATGGCCATGAGCATGGTTCAAAACAGGGTCTTCCTGAGAGCTATCAACAAGTTTGCAGAAACCATGA
ACCAGAAGTTCCTAGAACACACGAACTTTGAGTTCCAGCTGTGGAACAACTATTTTCATCTGGCAGTGGCTTTTATCACCCAGGATTCTC
TGCAGCTGGAGCAGTTCTCACACGCCAAATACAACAAAATCCTGAATAAGTATGGGGACATGAGACGGCTAATTGGCTTCTCCATCCGTG
ATATGTGGTACAAGCTTGGTCAGAACAAAATCTGCTTCATCCCAGGCATGGTAGGACCTATATTAGAGATGACACTTATCCCTGAGGCTG
AGCTCCGGAAAGCCACCATACCAATCTTCTTCGACATGATGCTGTGTGAATATCAAAGAAGTGGGGATTTCAAAAAGTTTGAAAACGAAA
TCATCCTGAAGCTGGACCACGAGGTAGAAGGGGGCCGAGGCGACGAGCAGTACATGCAGCTCCTGGAGTCAATCCTGATGGAATGTGCTG
CAGAGCACCCAACCATTGCCAAGTCGGTGGAGAACTTCGTGAACCTGGTCAAAGGCCTCCTGGAGAAGCTGCTGGATTACCGGGGTGTGA
TGACAGATGAGAGCAAAGACAACCGCATGAGCTGCACCGTGAACCTGCTGAATTTCTACAAAGATAACAACAGGGAGGAGATGTACATAA
GGTACCTGTACAAACTCCGCGATCTTCACCTGGACTGTGACAATTACACAGAGGCTGCCTACACGCTCCTTCTCCACACCTGGCTTCTCA
AGTGGTCGGATGAGCAGTGTGCATCACAGGTCATGCAGACAGGCCAGCAGCACCCCCAGACACACCGGCAGCTGAAGGAGACGCTCTACG
AGACCATCATAGGCTACTTTGACAAAGGAAAGATGTGGGAAGAGGCCATAAGTCTGTGCAAGGAGCTGGCGGAACAGTACGAGATGGAGA
TCTTTGACTATGAGCTGCTCAGCCAGAACCTGATCCAGCAGGCAAAATTCTATGAAAGCATCATGAAAATCCTCAGGCCCAAACCAGACT
ACTTTGCTGTTGGATACTACGGCCAGGGATTCCCCTCCTTCCTGCGGAACAAAGTGTTCATCTACCGCGGGAAGGAATATGAGCGAAGAG
AAGATTTCCAGATGCAGCTGATGACCCAGTTCCCCAATGCAGAGAAGATGAACACCACCTCTGCCCCGGGAGATGATGTGAAGAATGCCC
CAGGCCAGTATATCCAGTGCTTCACTGTCCAGCCTGTCTTGGATGAACATCCCAGGTTCAAGAATAAGCCAGTGCCTGACCAGATTATAA
ACTTCTACAAATCCAACTACGTGCAAAGGTTCCACTACTCCCGGCCCGTGCGCAGGGGGACCGTAGACCCAGAGAATGAGTTTGCTTCCA
TGTGGATTGAGAGAACCTCCTTCGTGACTGCATACAAGCTGCCGGGGATCCTGCGCTGGTTTGAGGTGGTGCACATGTCGCAGACCACAA
TTAGTCCTCTGGAGAATGCCATAGAAACCATGTCCACGGCCAATGAGAAGATCCTGATGATGATAAACCAGTACCAGAGTGATGAGACCC
TCCCCATCAACCCACTCTCCATGCTCCTGAACGGGATTGTGGACCCTGCTGTCATGGGAGGCTTCGCCAAGTATGAGAAGGCCTTCTTCA
CTGAAGAGTATGTCAGGGACCACCCTGAGGACCAGGACAAGCTGACCCACCTCAAGGACCTGATTGCATGGCAGATCCCCTTCTTGGGAG
CTGGGATTAAGATCCATGAGAAAAGGGTGTCAGATAACTTGCGACCCTTCCATGACCGGATGGAGGAATGTTTCAAGAACCTGAAAATGA
AGGTGGAGAAGGAGTACGGTGTCCGAGAGATGCCTGACTTTGACGACAGGAGAGTGGGCCGTCCCAGGTCTATGCTGCGCTCATACAGAC
AGATGTCCATCATCTCTCTGGCTTCCATGAATTCTGACTGCAGCACCCCCAGCAAGCCTACCTCAGAGAGCTTTGACCTGGAATTAGCAT
CACCCAAGACGCCGAGAGTGGAGCAGGAGGAACCGATCTCCCCGGGGAGCACCCTGCCTGAGGTCAAGCTGCGGAGGTCCAAGAAGAGGA
CAAAGAGAAGCAGCGTAGTTTTTGCGGATGAGAAAGCAGCTGCAGAGTCGGACCTGAAGCGGCTTTCCAGGAAGCATGAGTTCATGAGTG
ACACCAACCTCTCGGAGCATGCGGCCATCCCCCTCAAGGCGTCTGTCCTCTCTCAAATGAGCTTTGCCAGCCAGTCCATGCCTACCATCC
CAGCCCTGGCGCTCTCAGTGGCAGGCATCCCTGGGTTGGATGAGGCCAACACATCTCCCCGCCTCAGCCAGACCTTCCTCCAACTCTCAG
ATGGTGACAAGAAGACACTCACACGGAAGAAGGTCAATCAGTTCTTCAAGACAATGCTGGCCAGCAAATCGGCTGAAGAAGGCAAACAGA
TCCCAGACTCGCTGTCCACGGACCTGTGAGCTGCTGCTGACTAGGGCTGCATGGGAGAGCCAGGGAGGGGAGTTTCTGGAAGAGGAAAGC
CATGCGTGGAACATCGAAGCCTCAGAGAGTGGGAGACTGTCCCCATCAGTTGTCCTTACTTAGAGGAGACAGAGAGGCCAATCAGGTCCC
AGAGCTTGAATGCTAACAAGCCCAGCATCCCCTGGGGCTGTGATCATGGTGGATGAGGAAGCCTCAACGTAGATTCCTGAACTCAAGGTA
CCAGCAAGAATGCCTTCTCCCAGTGTGCTCTCCCCAACATCCTAGGCACAGCTTTCATAACCCAGTTTCTTAGGTGTAAGAAACTGTTTT
TATCTCATTTATTAAGTCTCAGAACTTAACAGAAAAGGAAGCCTTTTAAATATTCTTTTTAATTTTATTTTAGATTAACAGTTTTGTACT
TTACATTTTTTTATACAACCAACCAGTTTCTTTTCTAGCCAATCATCTCTGAAGAGTTGCTGTTTCTTACTGACAATAAAAAATGTTCTC

>86659_86659_1_SS18-DOCK2_SS18_chr18_23612363_ENST00000269137_DOCK2_chr5_169267761_ENST00000256935_length(amino acids)=1365AA_BP=435
MARVPPSGLPRRPSAWPRSIPPPRIPEVVQPERPASLPQFAVHPERSGLADSGDGGNMSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQ
CIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQM
NGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQ
QYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQD
AYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQAFTYHHIQEIMVQL
LRTVNRTVITMGRDHILISHFVACMTAILNQMGDQHYSFYIETFQTSSELVDFLMETFIMFKDLIGKNVYPGDWMAMSMVQNRVFLRAIN
KFAETMNQKFLEHTNFEFQLWNNYFHLAVAFITQDSLQLEQFSHAKYNKILNKYGDMRRLIGFSIRDMWYKLGQNKICFIPGMVGPILEM
TLIPEAELRKATIPIFFDMMLCEYQRSGDFKKFENEIILKLDHEVEGGRGDEQYMQLLESILMECAAEHPTIAKSVENFVNLVKGLLEKL
LDYRGVMTDESKDNRMSCTVNLLNFYKDNNREEMYIRYLYKLRDLHLDCDNYTEAAYTLLLHTWLLKWSDEQCASQVMQTGQQHPQTHRQ
LKETLYETIIGYFDKGKMWEEAISLCKELAEQYEMEIFDYELLSQNLIQQAKFYESIMKILRPKPDYFAVGYYGQGFPSFLRNKVFIYRG
KEYERREDFQMQLMTQFPNAEKMNTTSAPGDDVKNAPGQYIQCFTVQPVLDEHPRFKNKPVPDQIINFYKSNYVQRFHYSRPVRRGTVDP
ENEFASMWIERTSFVTAYKLPGILRWFEVVHMSQTTISPLENAIETMSTANEKILMMINQYQSDETLPINPLSMLLNGIVDPAVMGGFAK
YEKAFFTEEYVRDHPEDQDKLTHLKDLIAWQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRVGRPRS
MLRSYRQMSIISLASMNSDCSTPSKPTSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDLKRLSR
KHEFMSDTNLSEHAAIPLKASVLSQMSFASQSMPTIPALALSVAGIPGLDEANTSPRLSQTFLQLSDGDKKTLTRKKVNQFFKTMLASKS

--------------------------------------------------------------
>86659_86659_2_SS18-DOCK2_SS18_chr18_23612363_ENST00000415083_DOCK2_chr5_169267761_ENST00000256935_length(transcript)=4600nt_BP=1286nt
AGTTTGCCGTTCACCCGGAGCGCTCGGGACTTGCCGATAGTGGTGACGGCGGCAACATGTCTGTGGCTTTCGCGGCCCCGAGGCAGCGAG
GCAAGGGGGAGATCACTCCCGCTGCGATTCAGAAGATGTTGGATGACAATAACCATCTTATTCAGTGTATAATGGACTCTCAGAATAAAG
GAAAGACCTCAGAGTGTTCTCAGTATCAGCAGATGTTGCACACAAACTTGGTATACCTTGCTACAATAGCAGATTCTAATCAAAATATGC
AGTCTCTTTTACCAGCACCACCCACACAGAATATGCCTATGGGTCCTGGAGGGATGAATCAGAGCGGCCCTCCCCCACCTCCACGCTCTC
ACAACATGCCTTCAGATGGAATGGTAGGTGGGGGTCCTCCTGCACCGCACATGCAGAACCAGATGAACGGCCAGATGCCTGGGCCTAACC
ATATGCCTATGCAGGGACCTGGACCCAATCAACTCAATATGACAAACAGTTCCATGAATATGCCTTCAAGTAGCCATGGATCCATGGGAG
GTTACAACCATTCTGTGCCATCATCACAGAGCATGCCAGTACAGAATCAGATGACAATGAGTCAGGGACAACCAATGGGAAACTATGGTC
CCAGACCAAATATGAGTATGCAGCCAAACCAAGGTCCAATGATGCATCAGCAGCCTCCTTCTCAGCAATACAATATGCCACAGGGAGGCG
GACAGCATTACCAAGGACAGCAGCCACCTATGGGAATGATGGGTCAAGTTAACCAAGGCAATCATATGATGGGTCAGAGACAGATTCCTC
CCTATAGACCTCCTCAACAGGGCCCACCACAGCAGTACTCAGGCCAGGAAGACTATTACGGGGACCAATACAGTCATGGTGGACAAGGTC
CTCCAGAAGGCATGAACCAGCAATATTACCCTGATGGTCATAATGATTACGGTTATCAGCAACCGTCGTATCCTGAACAAGGCTACGATA
GGCCTTATGAGGATTCCTCACAACATTACTACGAAGGAGGAAATTCACAGTATGGCCAACAGCAAGATGCATACCAGGGACCACCTCCAC
AACAGGGATATCCACCCCAGCAGCAGCAGTACCCAGGGCAGCAAGGTTACCCAGGACAGCAGCAGGGCTACGGTCCTTCACAGGGTGGTC
CAGGTCCTCAGTATCCTAACTACCCACAGGGACAAGGTCAGCAGTATGGAGGATATAGACCAACACAGCCTGGACCACCACAGCCACCCC
AGCAGAGGCCTTATGGATATGACCAGGCCTTCACCTACCACCATATCCAGGAGATCATGGTCCAGCTGCTGCGGACAGTGAACCGGACAG
TCATCACCATGGGCCGGGATCACATTCTGATTAGTCACTTTGTGGCATGTATGACAGCCATCTTAAACCAGATGGGTGACCAGCACTACT
CCTTCTACATTGAGACCTTCCAGACCAGCTCTGAACTTGTGGACTTCTTGATGGAGACCTTCATCATGTTCAAGGACCTCATTGGAAAGA
ACGTGTACCCTGGAGACTGGATGGCCATGAGCATGGTTCAAAACAGGGTCTTCCTGAGAGCTATCAACAAGTTTGCAGAAACCATGAACC
AGAAGTTCCTAGAACACACGAACTTTGAGTTCCAGCTGTGGAACAACTATTTTCATCTGGCAGTGGCTTTTATCACCCAGGATTCTCTGC
AGCTGGAGCAGTTCTCACACGCCAAATACAACAAAATCCTGAATAAGTATGGGGACATGAGACGGCTAATTGGCTTCTCCATCCGTGATA
TGTGGTACAAGCTTGGTCAGAACAAAATCTGCTTCATCCCAGGCATGGTAGGACCTATATTAGAGATGACACTTATCCCTGAGGCTGAGC
TCCGGAAAGCCACCATACCAATCTTCTTCGACATGATGCTGTGTGAATATCAAAGAAGTGGGGATTTCAAAAAGTTTGAAAACGAAATCA
TCCTGAAGCTGGACCACGAGGTAGAAGGGGGCCGAGGCGACGAGCAGTACATGCAGCTCCTGGAGTCAATCCTGATGGAATGTGCTGCAG
AGCACCCAACCATTGCCAAGTCGGTGGAGAACTTCGTGAACCTGGTCAAAGGCCTCCTGGAGAAGCTGCTGGATTACCGGGGTGTGATGA
CAGATGAGAGCAAAGACAACCGCATGAGCTGCACCGTGAACCTGCTGAATTTCTACAAAGATAACAACAGGGAGGAGATGTACATAAGGT
ACCTGTACAAACTCCGCGATCTTCACCTGGACTGTGACAATTACACAGAGGCTGCCTACACGCTCCTTCTCCACACCTGGCTTCTCAAGT
GGTCGGATGAGCAGTGTGCATCACAGGTCATGCAGACAGGCCAGCAGCACCCCCAGACACACCGGCAGCTGAAGGAGACGCTCTACGAGA
CCATCATAGGCTACTTTGACAAAGGAAAGATGTGGGAAGAGGCCATAAGTCTGTGCAAGGAGCTGGCGGAACAGTACGAGATGGAGATCT
TTGACTATGAGCTGCTCAGCCAGAACCTGATCCAGCAGGCAAAATTCTATGAAAGCATCATGAAAATCCTCAGGCCCAAACCAGACTACT
TTGCTGTTGGATACTACGGCCAGGGATTCCCCTCCTTCCTGCGGAACAAAGTGTTCATCTACCGCGGGAAGGAATATGAGCGAAGAGAAG
ATTTCCAGATGCAGCTGATGACCCAGTTCCCCAATGCAGAGAAGATGAACACCACCTCTGCCCCGGGAGATGATGTGAAGAATGCCCCAG
GCCAGTATATCCAGTGCTTCACTGTCCAGCCTGTCTTGGATGAACATCCCAGGTTCAAGAATAAGCCAGTGCCTGACCAGATTATAAACT
TCTACAAATCCAACTACGTGCAAAGGTTCCACTACTCCCGGCCCGTGCGCAGGGGGACCGTAGACCCAGAGAATGAGTTTGCTTCCATGT
GGATTGAGAGAACCTCCTTCGTGACTGCATACAAGCTGCCGGGGATCCTGCGCTGGTTTGAGGTGGTGCACATGTCGCAGACCACAATTA
GTCCTCTGGAGAATGCCATAGAAACCATGTCCACGGCCAATGAGAAGATCCTGATGATGATAAACCAGTACCAGAGTGATGAGACCCTCC
CCATCAACCCACTCTCCATGCTCCTGAACGGGATTGTGGACCCTGCTGTCATGGGAGGCTTCGCCAAGTATGAGAAGGCCTTCTTCACTG
AAGAGTATGTCAGGGACCACCCTGAGGACCAGGACAAGCTGACCCACCTCAAGGACCTGATTGCATGGCAGATCCCCTTCTTGGGAGCTG
GGATTAAGATCCATGAGAAAAGGGTGTCAGATAACTTGCGACCCTTCCATGACCGGATGGAGGAATGTTTCAAGAACCTGAAAATGAAGG
TGGAGAAGGAGTACGGTGTCCGAGAGATGCCTGACTTTGACGACAGGAGAGTGGGCCGTCCCAGGTCTATGCTGCGCTCATACAGACAGA
TGTCCATCATCTCTCTGGCTTCCATGAATTCTGACTGCAGCACCCCCAGCAAGCCTACCTCAGAGAGCTTTGACCTGGAATTAGCATCAC
CCAAGACGCCGAGAGTGGAGCAGGAGGAACCGATCTCCCCGGGGAGCACCCTGCCTGAGGTCAAGCTGCGGAGGTCCAAGAAGAGGACAA
AGAGAAGCAGCGTAGTTTTTGCGGATGAGAAAGCAGCTGCAGAGTCGGACCTGAAGCGGCTTTCCAGGAAGCATGAGTTCATGAGTGACA
CCAACCTCTCGGAGCATGCGGCCATCCCCCTCAAGGCGTCTGTCCTCTCTCAAATGAGCTTTGCCAGCCAGTCCATGCCTACCATCCCAG
CCCTGGCGCTCTCAGTGGCAGGCATCCCTGGGTTGGATGAGGCCAACACATCTCCCCGCCTCAGCCAGACCTTCCTCCAACTCTCAGATG
GTGACAAGAAGACACTCACACGGAAGAAGGTCAATCAGTTCTTCAAGACAATGCTGGCCAGCAAATCGGCTGAAGAAGGCAAACAGATCC
CAGACTCGCTGTCCACGGACCTGTGAGCTGCTGCTGACTAGGGCTGCATGGGAGAGCCAGGGAGGGGAGTTTCTGGAAGAGGAAAGCCAT
GCGTGGAACATCGAAGCCTCAGAGAGTGGGAGACTGTCCCCATCAGTTGTCCTTACTTAGAGGAGACAGAGAGGCCAATCAGGTCCCAGA
GCTTGAATGCTAACAAGCCCAGCATCCCCTGGGGCTGTGATCATGGTGGATGAGGAAGCCTCAACGTAGATTCCTGAACTCAAGGTACCA
GCAAGAATGCCTTCTCCCAGTGTGCTCTCCCCAACATCCTAGGCACAGCTTTCATAACCCAGTTTCTTAGGTGTAAGAAACTGTTTTTAT
CTCATTTATTAAGTCTCAGAACTTAACAGAAAAGGAAGCCTTTTAAATATTCTTTTTAATTTTATTTTAGATTAACAGTTTTGTACTTTA
CATTTTTTTATACAACCAACCAGTTTCTTTTCTAGCCAATCATCTCTGAAGAGTTGCTGTTTCTTACTGACAATAAAAAATGTTCTCTTG

>86659_86659_2_SS18-DOCK2_SS18_chr18_23612363_ENST00000415083_DOCK2_chr5_169267761_ENST00000256935_length(amino acids)=1339AA_BP=409
MSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGM
NQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMT
MSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDY
YGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPG
QQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQAFTYHHIQEIMVQLLRTVNRTVITMGRDHILISHFVACMT
AILNQMGDQHYSFYIETFQTSSELVDFLMETFIMFKDLIGKNVYPGDWMAMSMVQNRVFLRAINKFAETMNQKFLEHTNFEFQLWNNYFH
LAVAFITQDSLQLEQFSHAKYNKILNKYGDMRRLIGFSIRDMWYKLGQNKICFIPGMVGPILEMTLIPEAELRKATIPIFFDMMLCEYQR
SGDFKKFENEIILKLDHEVEGGRGDEQYMQLLESILMECAAEHPTIAKSVENFVNLVKGLLEKLLDYRGVMTDESKDNRMSCTVNLLNFY
KDNNREEMYIRYLYKLRDLHLDCDNYTEAAYTLLLHTWLLKWSDEQCASQVMQTGQQHPQTHRQLKETLYETIIGYFDKGKMWEEAISLC
KELAEQYEMEIFDYELLSQNLIQQAKFYESIMKILRPKPDYFAVGYYGQGFPSFLRNKVFIYRGKEYERREDFQMQLMTQFPNAEKMNTT
SAPGDDVKNAPGQYIQCFTVQPVLDEHPRFKNKPVPDQIINFYKSNYVQRFHYSRPVRRGTVDPENEFASMWIERTSFVTAYKLPGILRW
FEVVHMSQTTISPLENAIETMSTANEKILMMINQYQSDETLPINPLSMLLNGIVDPAVMGGFAKYEKAFFTEEYVRDHPEDQDKLTHLKD
LIAWQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRVGRPRSMLRSYRQMSIISLASMNSDCSTPSKP
TSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDLKRLSRKHEFMSDTNLSEHAAIPLKASVLSQM

--------------------------------------------------------------
>86659_86659_3_SS18-DOCK2_SS18_chr18_23612363_ENST00000545952_DOCK2_chr5_169267761_ENST00000256935_length(transcript)=4598nt_BP=1284nt
ACTTGCCGATAGTGGTGACGGCGGCAACATGTCTGTGGCTTTCGCGGCCCCGAGGCAGCGAGGCAAGGGGGAGATCACTCCCGCTGCGAT
TCAGAAGATGTTGGATGACAATAACCATCTTATTCAGTGTATAATGGACTCTCAGAATAAAGGAAAGACCTCAGAGTGTTCTCAGGTCAT
GAATAAACCACATCTGTTAGTATGGTTTGGTCAGTGGTCCTCAGAAAATCTCATGTCGTGCAACCATACTAATACTCAAGCAAAGGAAAA
CTTGAAGGCCTAGACTGAAACAGGTATCAGCAGATGTTGCACACAAACTTGGTATACCTTGCTACAATAGCAGATTCTAATCAAAATATG
CAGTCTCTTTTACCAGCACCACCCACACAGAATATGCCTATGGGTCCTGGAGGGATGAATCAGAGCGGCCCTCCCCCACCTCCACGCTCT
CACAACATGCCTTCAGATGGAATGGTAGGTGGGGGTCCTCCTGCACCGCACATGCAGAACCAGATGAACGGCCAGATGCCTGGGCCTAAC
CATATGCCTATGCAGGGACCTGGACCCAATCAACTCAATATGACAAACAGTTCCATGAATATGCCTTCAAGTAGCCATGGATCCATGGGA
GGTTACAACCATTCTGTGCCATCATCACAGAGCATGCCAGTACAGAATCAGATGACAATGAGTCAGGGACAACCAATGGGAAACTATGGT
CCCAGACCAAATATGAGTATGCAGCCAAACCAAGGTCCAATGATGCATCAGCAGCCTCCTTCTCAGCAATACAATATGCCACAGGGAGGC
GGACAGCATTACCAAGGACAGCAGCCACCTATGGGAATGATGGGTCAAGTTAACCAAGGCAATCATATGATGGGTCAGAGACAGATTCCT
CCCTATAGACCTCCTCAACAGGGCCCACCACAGCAGTACTCAGGCCAGGAAGACTATTACGGGGACCAATACAGTCATGGTGGACAAGGT
CCTCCAGAAGGCATGAACCAGCAATATTACCCTGATGGAAATTCACAGTATGGCCAACAGCAAGATGCATACCAGGGACCACCTCCACAA
CAGGGATATCCACCCCAGCAGCAGCAGTACCCAGGGCAGCAAGGTTACCCAGGACAGCAGCAGGGCTACGGTCCTTCACAGGGTGGTCCA
GGTCCTCAGTATCCTAACTACCCACAGGGACAAGGTCAGCAGTATGGAGGATATAGACCAACACAGCCTGGACCACCACAGCCACCCCAG
CAGAGGCCTTATGGATATGACCAGGCCTTCACCTACCACCATATCCAGGAGATCATGGTCCAGCTGCTGCGGACAGTGAACCGGACAGTC
ATCACCATGGGCCGGGATCACATTCTGATTAGTCACTTTGTGGCATGTATGACAGCCATCTTAAACCAGATGGGTGACCAGCACTACTCC
TTCTACATTGAGACCTTCCAGACCAGCTCTGAACTTGTGGACTTCTTGATGGAGACCTTCATCATGTTCAAGGACCTCATTGGAAAGAAC
GTGTACCCTGGAGACTGGATGGCCATGAGCATGGTTCAAAACAGGGTCTTCCTGAGAGCTATCAACAAGTTTGCAGAAACCATGAACCAG
AAGTTCCTAGAACACACGAACTTTGAGTTCCAGCTGTGGAACAACTATTTTCATCTGGCAGTGGCTTTTATCACCCAGGATTCTCTGCAG
CTGGAGCAGTTCTCACACGCCAAATACAACAAAATCCTGAATAAGTATGGGGACATGAGACGGCTAATTGGCTTCTCCATCCGTGATATG
TGGTACAAGCTTGGTCAGAACAAAATCTGCTTCATCCCAGGCATGGTAGGACCTATATTAGAGATGACACTTATCCCTGAGGCTGAGCTC
CGGAAAGCCACCATACCAATCTTCTTCGACATGATGCTGTGTGAATATCAAAGAAGTGGGGATTTCAAAAAGTTTGAAAACGAAATCATC
CTGAAGCTGGACCACGAGGTAGAAGGGGGCCGAGGCGACGAGCAGTACATGCAGCTCCTGGAGTCAATCCTGATGGAATGTGCTGCAGAG
CACCCAACCATTGCCAAGTCGGTGGAGAACTTCGTGAACCTGGTCAAAGGCCTCCTGGAGAAGCTGCTGGATTACCGGGGTGTGATGACA
GATGAGAGCAAAGACAACCGCATGAGCTGCACCGTGAACCTGCTGAATTTCTACAAAGATAACAACAGGGAGGAGATGTACATAAGGTAC
CTGTACAAACTCCGCGATCTTCACCTGGACTGTGACAATTACACAGAGGCTGCCTACACGCTCCTTCTCCACACCTGGCTTCTCAAGTGG
TCGGATGAGCAGTGTGCATCACAGGTCATGCAGACAGGCCAGCAGCACCCCCAGACACACCGGCAGCTGAAGGAGACGCTCTACGAGACC
ATCATAGGCTACTTTGACAAAGGAAAGATGTGGGAAGAGGCCATAAGTCTGTGCAAGGAGCTGGCGGAACAGTACGAGATGGAGATCTTT
GACTATGAGCTGCTCAGCCAGAACCTGATCCAGCAGGCAAAATTCTATGAAAGCATCATGAAAATCCTCAGGCCCAAACCAGACTACTTT
GCTGTTGGATACTACGGCCAGGGATTCCCCTCCTTCCTGCGGAACAAAGTGTTCATCTACCGCGGGAAGGAATATGAGCGAAGAGAAGAT
TTCCAGATGCAGCTGATGACCCAGTTCCCCAATGCAGAGAAGATGAACACCACCTCTGCCCCGGGAGATGATGTGAAGAATGCCCCAGGC
CAGTATATCCAGTGCTTCACTGTCCAGCCTGTCTTGGATGAACATCCCAGGTTCAAGAATAAGCCAGTGCCTGACCAGATTATAAACTTC
TACAAATCCAACTACGTGCAAAGGTTCCACTACTCCCGGCCCGTGCGCAGGGGGACCGTAGACCCAGAGAATGAGTTTGCTTCCATGTGG
ATTGAGAGAACCTCCTTCGTGACTGCATACAAGCTGCCGGGGATCCTGCGCTGGTTTGAGGTGGTGCACATGTCGCAGACCACAATTAGT
CCTCTGGAGAATGCCATAGAAACCATGTCCACGGCCAATGAGAAGATCCTGATGATGATAAACCAGTACCAGAGTGATGAGACCCTCCCC
ATCAACCCACTCTCCATGCTCCTGAACGGGATTGTGGACCCTGCTGTCATGGGAGGCTTCGCCAAGTATGAGAAGGCCTTCTTCACTGAA
GAGTATGTCAGGGACCACCCTGAGGACCAGGACAAGCTGACCCACCTCAAGGACCTGATTGCATGGCAGATCCCCTTCTTGGGAGCTGGG
ATTAAGATCCATGAGAAAAGGGTGTCAGATAACTTGCGACCCTTCCATGACCGGATGGAGGAATGTTTCAAGAACCTGAAAATGAAGGTG
GAGAAGGAGTACGGTGTCCGAGAGATGCCTGACTTTGACGACAGGAGAGTGGGCCGTCCCAGGTCTATGCTGCGCTCATACAGACAGATG
TCCATCATCTCTCTGGCTTCCATGAATTCTGACTGCAGCACCCCCAGCAAGCCTACCTCAGAGAGCTTTGACCTGGAATTAGCATCACCC
AAGACGCCGAGAGTGGAGCAGGAGGAACCGATCTCCCCGGGGAGCACCCTGCCTGAGGTCAAGCTGCGGAGGTCCAAGAAGAGGACAAAG
AGAAGCAGCGTAGTTTTTGCGGATGAGAAAGCAGCTGCAGAGTCGGACCTGAAGCGGCTTTCCAGGAAGCATGAGTTCATGAGTGACACC
AACCTCTCGGAGCATGCGGCCATCCCCCTCAAGGCGTCTGTCCTCTCTCAAATGAGCTTTGCCAGCCAGTCCATGCCTACCATCCCAGCC
CTGGCGCTCTCAGTGGCAGGCATCCCTGGGTTGGATGAGGCCAACACATCTCCCCGCCTCAGCCAGACCTTCCTCCAACTCTCAGATGGT
GACAAGAAGACACTCACACGGAAGAAGGTCAATCAGTTCTTCAAGACAATGCTGGCCAGCAAATCGGCTGAAGAAGGCAAACAGATCCCA
GACTCGCTGTCCACGGACCTGTGAGCTGCTGCTGACTAGGGCTGCATGGGAGAGCCAGGGAGGGGAGTTTCTGGAAGAGGAAAGCCATGC
GTGGAACATCGAAGCCTCAGAGAGTGGGAGACTGTCCCCATCAGTTGTCCTTACTTAGAGGAGACAGAGAGGCCAATCAGGTCCCAGAGC
TTGAATGCTAACAAGCCCAGCATCCCCTGGGGCTGTGATCATGGTGGATGAGGAAGCCTCAACGTAGATTCCTGAACTCAAGGTACCAGC
AAGAATGCCTTCTCCCAGTGTGCTCTCCCCAACATCCTAGGCACAGCTTTCATAACCCAGTTTCTTAGGTGTAAGAAACTGTTTTTATCT
CATTTATTAAGTCTCAGAACTTAACAGAAAAGGAAGCCTTTTAAATATTCTTTTTAATTTTATTTTAGATTAACAGTTTTGTACTTTACA
TTTTTTTATACAACCAACCAGTTTCTTTTCTAGCCAATCATCTCTGAAGAGTTGCTGTTTCTTACTGACAATAAAAAATGTTCTCTTGGT

>86659_86659_3_SS18-DOCK2_SS18_chr18_23612363_ENST00000545952_DOCK2_chr5_169267761_ENST00000256935_length(amino acids)=1256AA_BP=326
MLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQ
LNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPM
GMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQDAYQGPPPQQGYPPQQQQYP
GQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQAFTYHHIQEIMVQLLRTVNRTVITMGRDHILIS
HFVACMTAILNQMGDQHYSFYIETFQTSSELVDFLMETFIMFKDLIGKNVYPGDWMAMSMVQNRVFLRAINKFAETMNQKFLEHTNFEFQ
LWNNYFHLAVAFITQDSLQLEQFSHAKYNKILNKYGDMRRLIGFSIRDMWYKLGQNKICFIPGMVGPILEMTLIPEAELRKATIPIFFDM
MLCEYQRSGDFKKFENEIILKLDHEVEGGRGDEQYMQLLESILMECAAEHPTIAKSVENFVNLVKGLLEKLLDYRGVMTDESKDNRMSCT
VNLLNFYKDNNREEMYIRYLYKLRDLHLDCDNYTEAAYTLLLHTWLLKWSDEQCASQVMQTGQQHPQTHRQLKETLYETIIGYFDKGKMW
EEAISLCKELAEQYEMEIFDYELLSQNLIQQAKFYESIMKILRPKPDYFAVGYYGQGFPSFLRNKVFIYRGKEYERREDFQMQLMTQFPN
AEKMNTTSAPGDDVKNAPGQYIQCFTVQPVLDEHPRFKNKPVPDQIINFYKSNYVQRFHYSRPVRRGTVDPENEFASMWIERTSFVTAYK
LPGILRWFEVVHMSQTTISPLENAIETMSTANEKILMMINQYQSDETLPINPLSMLLNGIVDPAVMGGFAKYEKAFFTEEYVRDHPEDQD
KLTHLKDLIAWQIPFLGAGIKIHEKRVSDNLRPFHDRMEECFKNLKMKVEKEYGVREMPDFDDRRVGRPRSMLRSYRQMSIISLASMNSD
CSTPSKPTSESFDLELASPKTPRVEQEEPISPGSTLPEVKLRRSKKRTKRSSVVFADEKAAAESDLKRLSRKHEFMSDTNLSEHAAIPLK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SS18-DOCK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneDOCK2chr18:23612363chr5:169267761ENST000002569352552939_1476901.01831.0CRKL


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SS18-DOCK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SS18-DOCK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource