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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SS18-SSX4B (FusionGDB2 ID:86686)

Fusion Gene Summary for SS18-SSX4B

Fusion gene summary

Fusion gene information	Fusion gene name: SS18-SSX4B
	Fusion gene ID: 86686
		Hgene	Tgene
	Gene symbol	SS18	SSX4B
	Gene ID	6760	548313
	Gene name	SS18 subunit of BAF chromatin remodeling complex	SSX family member 4B
	Synonyms	SSXT\|SYT	CT5.4
	Cytomap	18q11.2	Xp11.23
	Type of gene	protein-coding	protein-coding
	Description	protein SSXTSS18, nBAF chromatin remodeling complex subunitsynovial sarcoma translocated to X chromosome proteinsynovial sarcoma translocation, chromosome 18synovial sarcoma, translocated to X chromosome	protein SSX4cancer/testis antigen 5.4synovial sarcoma, X breakpoint 4B
	Modification date	20200329	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000269137, ENST00000415083, ENST00000539849, ENST00000542420, ENST00000542743, ENST00000545952, ENST00000585241,	ENST00000376884, ENST00000396928,
Fusion gene scores	* DoF score	24 X 33 X 8=6336	1 X 1 X 1=1
	# samples	38	1
	** MAII score	log2(38/6336*10)=-4.05950101174866 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: SS18 [Title/Abstract] AND SSX4B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SS18(23612362)-SSX4B(48263000), # samples:1
Anticipated loss of major functional domain due to fusion event.	SS18-SSX4B seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SS18	GO:0045944	positive regulation of transcription by RNA polymerase II	15919756

Fusion gene breakpoints across SS18 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SSX4B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS5.0	N/A	AF257501	SS18	chr18	23612362	-	SSX4B	chrX	48263000	-

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Fusion Gene ORF analysis for SS18-SSX4B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000269137	ENST00000376884	SS18	chr18	23612362	-	SSX4B	chrX	48263000	-
Frame-shift	ENST00000415083	ENST00000376884	SS18	chr18	23612362	-	SSX4B	chrX	48263000	-
Frame-shift	ENST00000539849	ENST00000396928	SS18	chr18	23612362	-	SSX4B	chrX	48263000	-
Frame-shift	ENST00000542420	ENST00000396928	SS18	chr18	23612362	-	SSX4B	chrX	48263000	-
Frame-shift	ENST00000542743	ENST00000376884	SS18	chr18	23612362	-	SSX4B	chrX	48263000	-
Frame-shift	ENST00000542743	ENST00000396928	SS18	chr18	23612362	-	SSX4B	chrX	48263000	-
Frame-shift	ENST00000545952	ENST00000376884	SS18	chr18	23612362	-	SSX4B	chrX	48263000	-
In-frame	ENST00000269137	ENST00000396928	SS18	chr18	23612362	-	SSX4B	chrX	48263000	-
In-frame	ENST00000415083	ENST00000396928	SS18	chr18	23612362	-	SSX4B	chrX	48263000	-
In-frame	ENST00000539849	ENST00000376884	SS18	chr18	23612362	-	SSX4B	chrX	48263000	-
In-frame	ENST00000542420	ENST00000376884	SS18	chr18	23612362	-	SSX4B	chrX	48263000	-
In-frame	ENST00000545952	ENST00000396928	SS18	chr18	23612362	-	SSX4B	chrX	48263000	-
intron-3CDS	ENST00000585241	ENST00000376884	SS18	chr18	23612362	-	SSX4B	chrX	48263000	-
intron-3CDS	ENST00000585241	ENST00000396928	SS18	chr18	23612362	-	SSX4B	chrX	48263000	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000415083	SS18	chr18	23612362	-	ENST00000396928	SSX4B	chrX	48263000	-	1979	1286	56	1417	453
ENST00000542420	SS18	chr18	23612362	-	ENST00000376884	SSX4B	chrX	48263000	-	1976	1283	59	1414	451
ENST00000539849	SS18	chr18	23612362	-	ENST00000376884	SSX4B	chrX	48263000	-	1867	1174	190	1305	371
ENST00000269137	SS18	chr18	23612362	-	ENST00000396928	SSX4B	chrX	48263000	-	2162	1469	161	1600	479
ENST00000545952	SS18	chr18	23612362	-	ENST00000396928	SSX4B	chrX	48263000	-	1977	1284	303	1415	370

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000415083	ENST00000396928	SS18	chr18	23612362	-	SSX4B	chrX	48263000	-	0.00179495	0.99820507
ENST00000542420	ENST00000376884	SS18	chr18	23612362	-	SSX4B	chrX	48263000	-	0.001043028	0.9989569
ENST00000539849	ENST00000376884	SS18	chr18	23612362	-	SSX4B	chrX	48263000	-	0.001335108	0.99866486
ENST00000269137	ENST00000396928	SS18	chr18	23612362	-	SSX4B	chrX	48263000	-	0.002188063	0.9978119
ENST00000545952	ENST00000396928	SS18	chr18	23612362	-	SSX4B	chrX	48263000	-	0.000949589	0.99905044

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Fusion Genomic Features for SS18-SSX4B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SS18-SSX4B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:23612362/chrX:48263000)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SS18

chr18:23612362

chrX:48263000

ENST00000269137

95_99

379

388.0

Compositional bias

Note=Poly-Pro

Hgene

SS18

chr18:23612362

chrX:48263000

ENST00000415083

95_99

410

419.0

Compositional bias

Note=Poly-Pro

Hgene

SS18

chr18:23612362

chrX:48263000

ENST00000269137

374_377

379

388.0

Motif

SH2-binding

Hgene

SS18

chr18:23612362

chrX:48263000

ENST00000269137

50_53

379

388.0

Motif

SH2-binding

Hgene

SS18

chr18:23612362

chrX:48263000

ENST00000415083

374_377

410

419.0

Motif

SH2-binding

Hgene

SS18

chr18:23612362

chrX:48263000

ENST00000415083

392_401

410

419.0

Motif

SH3-binding

Hgene

SS18

chr18:23612362

chrX:48263000

ENST00000415083

50_53

410

419.0

Motif

SH2-binding

Hgene

SS18

chr18:23612362

chrX:48263000

ENST00000269137

2_186

379

388.0

Region

Note=Transcriptional activation

Hgene

SS18

chr18:23612362

chrX:48263000

ENST00000269137

344_369

379

388.0

Region

Note=2 X 13 AA imperfect tandem repeats

Hgene

SS18

chr18:23612362

chrX:48263000

ENST00000415083

2_186

410

419.0

Region

Note=Transcriptional activation

Hgene

SS18

chr18:23612362

chrX:48263000

ENST00000415083

344_369

410

419.0

Region

Note=2 X 13 AA imperfect tandem repeats

Hgene

SS18

chr18:23612362

chrX:48263000

ENST00000269137

344_356

379

388.0

Repeat

Note=1

Hgene

SS18

chr18:23612362

chrX:48263000

ENST00000269137

357_369

379

388.0

Repeat

Note=2

Hgene

SS18

chr18:23612362

chrX:48263000

ENST00000415083

344_356

410

419.0

Repeat

Note=1

Hgene

SS18

chr18:23612362

chrX:48263000

ENST00000415083

357_369

410

419.0

Repeat

Note=2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SS18

chr18:23612362

chrX:48263000

ENST00000269137

175_418

379

388.0

Compositional bias

Note=Gln-rich

Hgene

SS18

chr18:23612362

chrX:48263000

ENST00000415083

175_418

410

419.0

Compositional bias

Note=Gln-rich

Hgene

SS18

chr18:23612362

chrX:48263000

ENST00000269137

392_401

379

388.0

Motif

SH3-binding

Hgene

SS18

chr18:23612362

chrX:48263000

ENST00000269137

413_416

379

388.0

Motif

SH2-binding

Hgene

SS18

chr18:23612362

chrX:48263000

ENST00000415083

413_416

410

419.0

Motif

SH2-binding

Tgene

SSX4B

chr18:23612362

chrX:48263000

ENST00000376884

20_83

155

377.6666666666667

Domain

KRAB-related

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Fusion Gene Sequence for SS18-SSX4B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>86686_86686_1_SS18-SSX4B_SS18_chr18_23612362_ENST00000269137_SSX4B_chrX_48263000_ENST00000396928_length(transcript)=2162nt_BP=1469nt
TTTCCTGAATCGCTGAAGCGGAGGGAGGACTAGGGCGCGACTCTACCATTAGCGCAAAGGGCCAGGGGGTGCCCATAAGGAGAGCTCGGG
GGATGCAGGGACGGTCAAGAAAGTTCGGCCAGGGCTAGGGGTCCCCCAGAGTGCGCAGAAGCGAGACATCCCTGGCCAGAGTGCCTCCTT
CAGGCCTGCCCCGCCGCCCGTCCGCTTGGCCCCGGAGCATCCCCCCTCCCCGCATTCCCGAGGTGGTTCAGCCCGAGAGGCCGGCGTCTC
TCCCCCAGTTTGCCGTTCACCCGGAGCGCTCGGGACTTGCCGATAGTGGTGACGGCGGCAACATGTCTGTGGCTTTCGCGGCCCCGAGGC
AGCGAGGCAAGGGGGAGATCACTCCCGCTGCGATTCAGAAGATGTTGGATGACAATAACCATCTTATTCAGTGTATAATGGACTCTCAGA
ATAAAGGAAAGACCTCAGAGTGTTCTCAGTATCAGCAGATGTTGCACACAAACTTGGTATACCTTGCTACAATAGCAGATTCTAATCAAA
ATATGCAGTCTCTTTTACCAGCACCACCCACACAGAATATGCCTATGGGTCCTGGAGGGATGAATCAGAGCGGCCCTCCCCCACCTCCAC
GCTCTCACAACATGCCTTCAGATGGAATGGTAGGTGGGGGTCCTCCTGCACCGCACATGCAGAACCAGATGAACGGCCAGATGCCTGGGC
CTAACCATATGCCTATGCAGGGACCTGGACCCAATCAACTCAATATGACAAACAGTTCCATGAATATGCCTTCAAGTAGCCATGGATCCA
TGGGAGGTTACAACCATTCTGTGCCATCATCACAGAGCATGCCAGTACAGAATCAGATGACAATGAGTCAGGGACAACCAATGGGAAACT
ATGGTCCCAGACCAAATATGAGTATGCAGCCAAACCAAGGTCCAATGATGCATCAGCAGCCTCCTTCTCAGCAATACAATATGCCACAGG
GAGGCGGACAGCATTACCAAGGACAGCAGCCACCTATGGGAATGATGGGTCAAGTTAACCAAGGCAATCATATGATGGGTCAGAGACAGA
TTCCTCCCTATAGACCTCCTCAACAGGGCCCACCACAGCAGTACTCAGGCCAGGAAGACTATTACGGGGACCAATACAGTCATGGTGGAC
AAGGTCCTCCAGAAGGCATGAACCAGCAATATTACCCTGATGGAAATTCACAGTATGGCCAACAGCAAGATGCATACCAGGGACCACCTC
CACAACAGGGATATCCACCCCAGCAGCAGCAGTACCCAGGGCAGCAAGGTTACCCAGGACAGCAGCAGGGCTACGGTCCTTCACAGGGTG
GTCCAGGTCCTCAGTATCCTAACTACCCACAGGGACAAGGTCAGCAGTATGGAGGATATAGACCAACACAGCCTGGACCACCACAGCCAC
CCCAGCAGAGGCCTTATGGATATGACCAGGACCCAAAAGGGGGAAACATGCCTGGACCCACAGACTGCGTGAGAGAAAGCAGCTGGTGGT
TTATGAAGAGATCAGCGACCCTGAGGAAGATGACGAGTAACTCCCCTCGGGGATATGACACATGCCCATGATGAGAAGCAGAACGTGGTG
ACCTTTCACGAACATGGGCATGGCTGCGGACCCCTCGTCATCAGGTGCATAGCAAGTGAAAGCAAGTGTTCACAACAGTGAAAAGTTGAG
CGTCATTTTTCTTAGTGTGCCAAGAGTTCGATGTTGGCGTTTCCGCTGTATTTTCTTGCAGTGTGCCATTCTGTTAGACATTAGCGTTTT
CGTTGATGAGCAAGACATGCTTAATGCATATTTCGGCTTGTGTATCCATGCACCTACCTCAGAAAACAAGTATTGTCAGGTATTCTCTCC
ATAGAACAGCACTACCCTCCTCTCTCCCCAGATGTGACTACTGAGGGGAGGTCTGAGTGTTTAATTTCCGATTTTTTCCTCTGCATTTAC
ACACACACCACACACGCACACACACACACCAAGTACCAGTATAAGCATCTCCCATCTGCTTTTCTCCATTGCCATGCGACCTGGTCAAGC
CCCCCTCACTCTGTTTCCTGTTCAGCATGTACTCCCCTCATCCGATTCCGTTGTATCAGTCACTGACAGTTAATAAACCTTTGCAAACGT

>86686_86686_1_SS18-SSX4B_SS18_chr18_23612362_ENST00000269137_SSX4B_chrX_48263000_ENST00000396928_length(amino acids)=479AA_BP=421
MARVPPSGLPRRPSAWPRSIPPPRIPEVVQPERPASLPQFAVHPERSGLADSGDGGNMSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQ
CIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQM
NGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQ
QYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQD
AYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQDPKGGNMPGPTDCV

--------------------------------------------------------------
>86686_86686_2_SS18-SSX4B_SS18_chr18_23612362_ENST00000415083_SSX4B_chrX_48263000_ENST00000396928_length(transcript)=1979nt_BP=1286nt
AGTTTGCCGTTCACCCGGAGCGCTCGGGACTTGCCGATAGTGGTGACGGCGGCAACATGTCTGTGGCTTTCGCGGCCCCGAGGCAGCGAG
GCAAGGGGGAGATCACTCCCGCTGCGATTCAGAAGATGTTGGATGACAATAACCATCTTATTCAGTGTATAATGGACTCTCAGAATAAAG
GAAAGACCTCAGAGTGTTCTCAGTATCAGCAGATGTTGCACACAAACTTGGTATACCTTGCTACAATAGCAGATTCTAATCAAAATATGC
AGTCTCTTTTACCAGCACCACCCACACAGAATATGCCTATGGGTCCTGGAGGGATGAATCAGAGCGGCCCTCCCCCACCTCCACGCTCTC
ACAACATGCCTTCAGATGGAATGGTAGGTGGGGGTCCTCCTGCACCGCACATGCAGAACCAGATGAACGGCCAGATGCCTGGGCCTAACC
ATATGCCTATGCAGGGACCTGGACCCAATCAACTCAATATGACAAACAGTTCCATGAATATGCCTTCAAGTAGCCATGGATCCATGGGAG
GTTACAACCATTCTGTGCCATCATCACAGAGCATGCCAGTACAGAATCAGATGACAATGAGTCAGGGACAACCAATGGGAAACTATGGTC
CCAGACCAAATATGAGTATGCAGCCAAACCAAGGTCCAATGATGCATCAGCAGCCTCCTTCTCAGCAATACAATATGCCACAGGGAGGCG
GACAGCATTACCAAGGACAGCAGCCACCTATGGGAATGATGGGTCAAGTTAACCAAGGCAATCATATGATGGGTCAGAGACAGATTCCTC
CCTATAGACCTCCTCAACAGGGCCCACCACAGCAGTACTCAGGCCAGGAAGACTATTACGGGGACCAATACAGTCATGGTGGACAAGGTC
CTCCAGAAGGCATGAACCAGCAATATTACCCTGATGGTCATAATGATTACGGTTATCAGCAACCGTCGTATCCTGAACAAGGCTACGATA
GGCCTTATGAGGATTCCTCACAACATTACTACGAAGGAGGAAATTCACAGTATGGCCAACAGCAAGATGCATACCAGGGACCACCTCCAC
AACAGGGATATCCACCCCAGCAGCAGCAGTACCCAGGGCAGCAAGGTTACCCAGGACAGCAGCAGGGCTACGGTCCTTCACAGGGTGGTC
CAGGTCCTCAGTATCCTAACTACCCACAGGGACAAGGTCAGCAGTATGGAGGATATAGACCAACACAGCCTGGACCACCACAGCCACCCC
AGCAGAGGCCTTATGGATATGACCAGGACCCAAAAGGGGGAAACATGCCTGGACCCACAGACTGCGTGAGAGAAAGCAGCTGGTGGTTTA
TGAAGAGATCAGCGACCCTGAGGAAGATGACGAGTAACTCCCCTCGGGGATATGACACATGCCCATGATGAGAAGCAGAACGTGGTGACC
TTTCACGAACATGGGCATGGCTGCGGACCCCTCGTCATCAGGTGCATAGCAAGTGAAAGCAAGTGTTCACAACAGTGAAAAGTTGAGCGT
CATTTTTCTTAGTGTGCCAAGAGTTCGATGTTGGCGTTTCCGCTGTATTTTCTTGCAGTGTGCCATTCTGTTAGACATTAGCGTTTTCGT
TGATGAGCAAGACATGCTTAATGCATATTTCGGCTTGTGTATCCATGCACCTACCTCAGAAAACAAGTATTGTCAGGTATTCTCTCCATA
GAACAGCACTACCCTCCTCTCTCCCCAGATGTGACTACTGAGGGGAGGTCTGAGTGTTTAATTTCCGATTTTTTCCTCTGCATTTACACA
CACACCACACACGCACACACACACACCAAGTACCAGTATAAGCATCTCCCATCTGCTTTTCTCCATTGCCATGCGACCTGGTCAAGCCCC

>86686_86686_2_SS18-SSX4B_SS18_chr18_23612362_ENST00000415083_SSX4B_chrX_48263000_ENST00000396928_length(amino acids)=453AA_BP=395
MSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGM
NQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMT
MSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDY
YGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPG
QQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQDPKGGNMPGPTDCVRESSWWFMKRSATLRKMTSNSPRGYD

--------------------------------------------------------------
>86686_86686_3_SS18-SSX4B_SS18_chr18_23612362_ENST00000539849_SSX4B_chrX_48263000_ENST00000376884_length(transcript)=1867nt_BP=1174nt
GACTTGCCGATAGTGGTGACGGCGGCAACATGTCTGTGGCTTTCGCGGCCCCGAGGCAGCGAGGCAAGGGGGAGATCACTCCCGCTGCGA
TTCAGAAGATGTTGGATGACAATAACCATCTTATTCAGTGTATAATGGACTCTCAGAATAAAGGAAAGACCTCAGAGTGTTCTCACCACC
CACACAGAATATGCCTATGGGTCCTGGAGGGATGAATCAGAGCGGCCCTCCCCCACCTCCACGCTCTCACAACATGCCTTCAGATGGAAT
GGTAGGTGGGGGTCCTCCTGCACCGCACATGCAGAACCAGATGAACGGCCAGATGCCTGGGCCTAACCATATGCCTATGCAGGGACCTGG
ACCCAATCAACTCAATATGACAAACAGTTCCATGAATATGCCTTCAAGTAGCCATGGATCCATGGGAGGTTACAACCATTCTGTGCCATC
ATCACAGAGCATGCCAGTACAGAATCAGATGACAATGAGTCAGGGACAACCAATGGGAAACTATGGTCCCAGACCAAATATGAGTATGCA
GCCAAACCAAGGTCCAATGATGCATCAGCAGCCTCCTTCTCAGCAATACAATATGCCACAGGGAGGCGGACAGCATTACCAAGGACAGCA
GCCACCTATGGGAATGATGGGTCAAGTTAACCAAGGCAATCATATGATGGGTCAGAGACAGATTCCTCCCTATAGACCTCCTCAACAGGG
CCCACCACAGCAGTACTCAGGCCAGGAAGACTATTACGGGGACCAATACAGTCATGGTGGACAAGGTCCTCCAGAAGGCATGAACCAGCA
ATATTACCCTGATGGTCATAATGATTACGGTTATCAGCAACCGTCGTATCCTGAACAAGGCTACGATAGGCCTTATGAGGATTCCTCACA
ACATTACTACGAAGGAGGAAATTCACAGTATGGCCAACAGCAAGATGCATACCAGGGACCACCTCCACAACAGGGATATCCACCCCAGCA
GCAGCAGTACCCAGGGCAGCAAGGTTACCCAGGACAGCAGCAGGGCTACGGTCCTTCACAGGGTGGTCCAGGTCCTCAGTATCCTAACTA
CCCACAGGGACAAGGTCAGCAGTATGGAGGATATAGACCAACACAGCCTGGACCACCACAGCCACCCCAGCAGAGGCCTTATGGATATGA
CCAGGACCCAAAAGGGGGAAACATGCCTGGACCCACAGACTGCGTGAGAGAAAGCAGCTGGTGGTTTATGAAGAGATCAGCGACCCTGAG
GAAGATGACGAGTAACTCCCCTCGGGGATATGACACATGCCCATGATGAGAAGCAGAACGTGGTGACCTTTCACGAACATGGGCATGGCT
GCGGACCCCTCGTCATCAGGTGCATAGCAAGTGAAAGCAAGTGTTCACAACAGTGAAAAGTTGAGCGTCATTTTTCTTAGTGTGCCAAGA
GTTCGATGTTGGCGTTTCCGCTGTATTTTCTTGCAGTGTGCCATTCTGTTAGACATTAGCGTTTTCGTTGATGAGCAAGACATGCTTAAT
GCATATTTCGGCTTGTGTATCCATGCACCTACCTCAGAAAACAAGTATTGTCAGGTATTCTCTCCATAGAACAGCACTACCCTCCTCTCT
CCCCAGATGTGACTACTGAGGGGAGGTCTGAGTGTTTAATTTCCGATTTTTTCCTCTGCATTTACACACACACCACACACGCACACACAC
ACACCAAGTACCAGTATAAGCATCTCCCATCTGCTTTTCTCCATTGCCATGCGACCTGGTCAAGCCCCCCTCACTCTGTTTCCTGTTCAG

>86686_86686_3_SS18-SSX4B_SS18_chr18_23612362_ENST00000539849_SSX4B_chrX_48263000_ENST00000376884_length(amino acids)=371AA_BP=313
MPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQS
MPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQ
QYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQQY
PGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQDPKGGNMPGPTDCVRESSWWFMKRSATLRKMT

--------------------------------------------------------------
>86686_86686_4_SS18-SSX4B_SS18_chr18_23612362_ENST00000542420_SSX4B_chrX_48263000_ENST00000376884_length(transcript)=1976nt_BP=1283nt
CCTTCCACCTCTGCCCTATCTCGGCAGATGCTCCACGGATTTGCACGAACTCCCGAGTCTTGACCTCCCTCCCCTCTCCGGGCTGCCGGG
ACAACTCGGGGCGGCCACTCTTGCCAGGAGGCATGTTGGATGACAATAACCATCTTATTCAGTGTATAATGGACTCTCAGAATAAAGGAA
AGACCTCAGAGTGTTCTCAGTATCAGCAGATGTTGCACACAAACTTGGTATACCTTGCTACAATAGCAGATTCTAATCAAAATATGCAGT
CTCTTTTACCAGCACCACCCACACAGAATATGCCTATGGGTCCTGGAGGGATGAATCAGAGCGGCCCTCCCCCACCTCCACGCTCTCACA
ACATGCCTTCAGATGGAATGGTAGGTGGGGGTCCTCCTGCACCGCACATGCAGAACCAGATGAACGGCCAGATGCCTGGGCCTAACCATA
TGCCTATGCAGGGACCTGGACCCAATCAACTCAATATGACAAACAGTTCCATGAATATGCCTTCAAGTAGCCATGGATCCATGGGAGGTT
ACAACCATTCTGTGCCATCATCACAGAGCATGCCAGTACAGAATCAGATGACAATGAGTCAGGGACAACCAATGGGAAACTATGGTCCCA
GACCAAATATGAGTATGCAGCCAAACCAAGGTCCAATGATGCATCAGCAGCCTCCTTCTCAGCAATACAATATGCCACAGGGAGGCGGAC
AGCATTACCAAGGACAGCAGCCACCTATGGGAATGATGGGTCAAGTTAACCAAGGCAATCATATGATGGGTCAGAGACAGATTCCTCCCT
ATAGACCTCCTCAACAGGGCCCACCACAGCAGTACTCAGGCCAGGAAGACTATTACGGGGACCAATACAGTCATGGTGGACAAGGTCCTC
CAGAAGGCATGAACCAGCAATATTACCCTGATGGTCATAATGATTACGGTTATCAGCAACCGTCGTATCCTGAACAAGGCTACGATAGGC
CTTATGAGGATTCCTCACAACATTACTACGAAGGAGGAAATTCACAGTATGGCCAACAGCAAGATGCATACCAGGGACCACCTCCACAAC
AGGGATATCCACCCCAGCAGCAGCAGTACCCAGGGCAGCAAGGTTACCCAGGACAGCAGCAGGGCTACGGTCCTTCACAGGGTGGTCCAG
GTCCTCAGTATCCTAACTACCCACAGGGACAAGGTCAGCAGTATGGAGGATATAGACCAACACAGCCTGGACCACCACAGCCACCCCAGC
AGAGGCCTTATGGATATGACCAGGACCCAAAAGGGGGAAACATGCCTGGACCCACAGACTGCGTGAGAGAAAGCAGCTGGTGGTTTATGA
AGAGATCAGCGACCCTGAGGAAGATGACGAGTAACTCCCCTCGGGGATATGACACATGCCCATGATGAGAAGCAGAACGTGGTGACCTTT
CACGAACATGGGCATGGCTGCGGACCCCTCGTCATCAGGTGCATAGCAAGTGAAAGCAAGTGTTCACAACAGTGAAAAGTTGAGCGTCAT
TTTTCTTAGTGTGCCAAGAGTTCGATGTTGGCGTTTCCGCTGTATTTTCTTGCAGTGTGCCATTCTGTTAGACATTAGCGTTTTCGTTGA
TGAGCAAGACATGCTTAATGCATATTTCGGCTTGTGTATCCATGCACCTACCTCAGAAAACAAGTATTGTCAGGTATTCTCTCCATAGAA
CAGCACTACCCTCCTCTCTCCCCAGATGTGACTACTGAGGGGAGGTCTGAGTGTTTAATTTCCGATTTTTTCCTCTGCATTTACACACAC
ACCACACACGCACACACACACACCAAGTACCAGTATAAGCATCTCCCATCTGCTTTTCTCCATTGCCATGCGACCTGGTCAAGCCCCCCT

>86686_86686_4_SS18-SSX4B_SS18_chr18_23612362_ENST00000542420_SSX4B_chrX_48263000_ENST00000376884_length(amino acids)=451AA_BP=393
MTSLPSPGCRDNSGRPLLPGGMLDDNNHLIQCIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQ
SGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMS
QGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYG
DQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPGQQ
QGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQDPKGGNMPGPTDCVRESSWWFMKRSATLRKMTSNSPRGYDTC

--------------------------------------------------------------
>86686_86686_5_SS18-SSX4B_SS18_chr18_23612362_ENST00000545952_SSX4B_chrX_48263000_ENST00000396928_length(transcript)=1977nt_BP=1284nt
ACTTGCCGATAGTGGTGACGGCGGCAACATGTCTGTGGCTTTCGCGGCCCCGAGGCAGCGAGGCAAGGGGGAGATCACTCCCGCTGCGAT
TCAGAAGATGTTGGATGACAATAACCATCTTATTCAGTGTATAATGGACTCTCAGAATAAAGGAAAGACCTCAGAGTGTTCTCAGGTCAT
GAATAAACCACATCTGTTAGTATGGTTTGGTCAGTGGTCCTCAGAAAATCTCATGTCGTGCAACCATACTAATACTCAAGCAAAGGAAAA
CTTGAAGGCCTAGACTGAAACAGGTATCAGCAGATGTTGCACACAAACTTGGTATACCTTGCTACAATAGCAGATTCTAATCAAAATATG
CAGTCTCTTTTACCAGCACCACCCACACAGAATATGCCTATGGGTCCTGGAGGGATGAATCAGAGCGGCCCTCCCCCACCTCCACGCTCT
CACAACATGCCTTCAGATGGAATGGTAGGTGGGGGTCCTCCTGCACCGCACATGCAGAACCAGATGAACGGCCAGATGCCTGGGCCTAAC
CATATGCCTATGCAGGGACCTGGACCCAATCAACTCAATATGACAAACAGTTCCATGAATATGCCTTCAAGTAGCCATGGATCCATGGGA
GGTTACAACCATTCTGTGCCATCATCACAGAGCATGCCAGTACAGAATCAGATGACAATGAGTCAGGGACAACCAATGGGAAACTATGGT
CCCAGACCAAATATGAGTATGCAGCCAAACCAAGGTCCAATGATGCATCAGCAGCCTCCTTCTCAGCAATACAATATGCCACAGGGAGGC
GGACAGCATTACCAAGGACAGCAGCCACCTATGGGAATGATGGGTCAAGTTAACCAAGGCAATCATATGATGGGTCAGAGACAGATTCCT
CCCTATAGACCTCCTCAACAGGGCCCACCACAGCAGTACTCAGGCCAGGAAGACTATTACGGGGACCAATACAGTCATGGTGGACAAGGT
CCTCCAGAAGGCATGAACCAGCAATATTACCCTGATGGAAATTCACAGTATGGCCAACAGCAAGATGCATACCAGGGACCACCTCCACAA
CAGGGATATCCACCCCAGCAGCAGCAGTACCCAGGGCAGCAAGGTTACCCAGGACAGCAGCAGGGCTACGGTCCTTCACAGGGTGGTCCA
GGTCCTCAGTATCCTAACTACCCACAGGGACAAGGTCAGCAGTATGGAGGATATAGACCAACACAGCCTGGACCACCACAGCCACCCCAG
CAGAGGCCTTATGGATATGACCAGGACCCAAAAGGGGGAAACATGCCTGGACCCACAGACTGCGTGAGAGAAAGCAGCTGGTGGTTTATG
AAGAGATCAGCGACCCTGAGGAAGATGACGAGTAACTCCCCTCGGGGATATGACACATGCCCATGATGAGAAGCAGAACGTGGTGACCTT
TCACGAACATGGGCATGGCTGCGGACCCCTCGTCATCAGGTGCATAGCAAGTGAAAGCAAGTGTTCACAACAGTGAAAAGTTGAGCGTCA
TTTTTCTTAGTGTGCCAAGAGTTCGATGTTGGCGTTTCCGCTGTATTTTCTTGCAGTGTGCCATTCTGTTAGACATTAGCGTTTTCGTTG
ATGAGCAAGACATGCTTAATGCATATTTCGGCTTGTGTATCCATGCACCTACCTCAGAAAACAAGTATTGTCAGGTATTCTCTCCATAGA
ACAGCACTACCCTCCTCTCTCCCCAGATGTGACTACTGAGGGGAGGTCTGAGTGTTTAATTTCCGATTTTTTCCTCTGCATTTACACACA
CACCACACACGCACACACACACACCAAGTACCAGTATAAGCATCTCCCATCTGCTTTTCTCCATTGCCATGCGACCTGGTCAAGCCCCCC

>86686_86686_5_SS18-SSX4B_SS18_chr18_23612362_ENST00000545952_SSX4B_chrX_48263000_ENST00000396928_length(amino acids)=370AA_BP=312
MLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQ
LNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPM
GMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGNSQYGQQQDAYQGPPPQQGYPPQQQQYP
GQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQDPKGGNMPGPTDCVRESSWWFMKRSATLRKMTS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SS18-SSX4B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SS18-SSX4B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for SS18-SSX4B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source