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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SSBP1-SKIL (FusionGDB2 ID:86705)

Fusion Gene Summary for SSBP1-SKIL

check button Fusion gene summary
Fusion gene informationFusion gene name: SSBP1-SKIL
Fusion gene ID: 86705
HgeneTgene
Gene symbol

SSBP1

SKIL

Gene ID

6742

6498

Gene namesingle stranded DNA binding protein 1SKI like proto-oncogene
SynonymsMt-SSB|SOSS-B1|SSBP|mtSSBSNO|SnoA|SnoI|SnoN
Cytomap

7q34

3q26.2

Type of geneprotein-codingprotein-coding
Descriptionsingle-stranded DNA-binding protein, mitochondrialPWP1-interacting protein 17single-stranded DNA binding protein 1, mitochondrialski-like proteinSKI-like oncogeneski-related oncogene snoN
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000469123, ENST00000265304, 
ENST00000465582, ENST00000481508, 
ENST00000484178, ENST00000498107, 
ENST00000259119, ENST00000413427, 
ENST00000426052, ENST00000458537, 
ENST00000490989, 
Fusion gene scores* DoF score6 X 6 X 3=10824 X 9 X 6=1296
# samples 624
** MAII scorelog2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/1296*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SSBP1 [Title/Abstract] AND SKIL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSSBP1(141445318)-SKIL(170075509), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSSBP1

GO:0006268

DNA unwinding involved in DNA replication

26446790

HgeneSSBP1

GO:0051096

positive regulation of helicase activity

12975372

HgeneSSBP1

GO:1905776

positive regulation of DNA helicase activity

15167897


check buttonFusion gene breakpoints across SSBP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SKIL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ADB038344SSBP1chr7

141445318

+SKILchr3

170075509

+


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Fusion Gene ORF analysis for SSBP1-SKIL

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000469123ENST00000259119SSBP1chr7

141445318

+SKILchr3

170075509

+
3UTR-intronENST00000469123ENST00000413427SSBP1chr7

141445318

+SKILchr3

170075509

+
3UTR-intronENST00000469123ENST00000426052SSBP1chr7

141445318

+SKILchr3

170075509

+
3UTR-intronENST00000469123ENST00000458537SSBP1chr7

141445318

+SKILchr3

170075509

+
3UTR-intronENST00000469123ENST00000490989SSBP1chr7

141445318

+SKILchr3

170075509

+
5CDS-intronENST00000265304ENST00000413427SSBP1chr7

141445318

+SKILchr3

170075509

+
5CDS-intronENST00000265304ENST00000426052SSBP1chr7

141445318

+SKILchr3

170075509

+
5CDS-intronENST00000265304ENST00000458537SSBP1chr7

141445318

+SKILchr3

170075509

+
5CDS-intronENST00000265304ENST00000490989SSBP1chr7

141445318

+SKILchr3

170075509

+
5CDS-intronENST00000465582ENST00000413427SSBP1chr7

141445318

+SKILchr3

170075509

+
5CDS-intronENST00000465582ENST00000426052SSBP1chr7

141445318

+SKILchr3

170075509

+
5CDS-intronENST00000465582ENST00000458537SSBP1chr7

141445318

+SKILchr3

170075509

+
5CDS-intronENST00000465582ENST00000490989SSBP1chr7

141445318

+SKILchr3

170075509

+
5CDS-intronENST00000481508ENST00000413427SSBP1chr7

141445318

+SKILchr3

170075509

+
5CDS-intronENST00000481508ENST00000426052SSBP1chr7

141445318

+SKILchr3

170075509

+
5CDS-intronENST00000481508ENST00000458537SSBP1chr7

141445318

+SKILchr3

170075509

+
5CDS-intronENST00000481508ENST00000490989SSBP1chr7

141445318

+SKILchr3

170075509

+
5CDS-intronENST00000484178ENST00000413427SSBP1chr7

141445318

+SKILchr3

170075509

+
5CDS-intronENST00000484178ENST00000426052SSBP1chr7

141445318

+SKILchr3

170075509

+
5CDS-intronENST00000484178ENST00000458537SSBP1chr7

141445318

+SKILchr3

170075509

+
5CDS-intronENST00000484178ENST00000490989SSBP1chr7

141445318

+SKILchr3

170075509

+
5CDS-intronENST00000498107ENST00000413427SSBP1chr7

141445318

+SKILchr3

170075509

+
5CDS-intronENST00000498107ENST00000426052SSBP1chr7

141445318

+SKILchr3

170075509

+
5CDS-intronENST00000498107ENST00000458537SSBP1chr7

141445318

+SKILchr3

170075509

+
5CDS-intronENST00000498107ENST00000490989SSBP1chr7

141445318

+SKILchr3

170075509

+
In-frameENST00000265304ENST00000259119SSBP1chr7

141445318

+SKILchr3

170075509

+
In-frameENST00000465582ENST00000259119SSBP1chr7

141445318

+SKILchr3

170075509

+
In-frameENST00000481508ENST00000259119SSBP1chr7

141445318

+SKILchr3

170075509

+
In-frameENST00000484178ENST00000259119SSBP1chr7

141445318

+SKILchr3

170075509

+
In-frameENST00000498107ENST00000259119SSBP1chr7

141445318

+SKILchr3

170075509

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265304SSBP1chr7141445318+ENST00000259119SKILchr3170075509+357051310703238722
ENST00000498107SSBP1chr7141445318+ENST00000259119SKILchr3170075509+362656911263294722
ENST00000465582SSBP1chr7141445318+ENST00000259119SKILchr3170075509+34914349913159722
ENST00000484178SSBP1chr7141445318+ENST00000259119SKILchr3170075509+355950210593227722
ENST00000481508SSBP1chr7141445318+ENST00000259119SKILchr3170075509+387281513723540722

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265304ENST00000259119SSBP1chr7141445318+SKILchr3170075509+0.0010629940.99893695
ENST00000498107ENST00000259119SSBP1chr7141445318+SKILchr3170075509+0.000956640.9990433
ENST00000465582ENST00000259119SSBP1chr7141445318+SKILchr3170075509+0.0011016730.99889827
ENST00000484178ENST00000259119SSBP1chr7141445318+SKILchr3170075509+0.0009689820.99903107
ENST00000481508ENST00000259119SSBP1chr7141445318+SKILchr3170075509+0.0008822860.9991177

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Fusion Genomic Features for SSBP1-SKIL


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SSBP1-SKIL


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:141445318/chr3:170075509)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSKILchr7:141445318chr3:170075509ENST00000259119-17536_6840685.0Coiled coilOntology_term=ECO:0000255
TgeneSKILchr7:141445318chr3:170075509ENST0000041342706536_6840639.0Coiled coilOntology_term=ECO:0000255
TgeneSKILchr7:141445318chr3:170075509ENST0000042605208536_6840665.0Coiled coilOntology_term=ECO:0000255
TgeneSKILchr7:141445318chr3:170075509ENST0000045853706536_6840685.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSSBP1chr7:141445318chr3:170075509ENST00000265304+1730_1410149.0DomainNote=SSB
HgeneSSBP1chr7:141445318chr3:170075509ENST00000465582+1830_1410212.0DomainNote=SSB
HgeneSSBP1chr7:141445318chr3:170075509ENST00000481508+1730_1410149.0DomainNote=SSB
HgeneSSBP1chr7:141445318chr3:170075509ENST00000484178+1730_1410149.0DomainNote=SSB
HgeneSSBP1chr7:141445318chr3:170075509ENST00000498107+1730_1410149.0DomainNote=SSB


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Fusion Gene Sequence for SSBP1-SKIL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>86705_86705_1_SSBP1-SKIL_SSBP1_chr7_141445318_ENST00000265304_SKIL_chr3_170075509_ENST00000259119_length(transcript)=3570nt_BP=513nt
CTGTTTCCTTTTTCCTCTGGCGAGCTTTGCGTTCCCTGTGCGCCGGAAGTGATCCCCTGCGTGGCTGGGCTGCTCGGGTTAGATCGTCAG
GAAAAGCCTAAAGATTAGACTGTAAGAAAAGAAAATAGAAGCCATGTTTCGAAGACCTGTATTACAGGTACTTCGTCAGTTTGTAAGACA
TGAGTCCGAAACAACTACCAGTTTGGTTCTTGAAAGATCCCTGAATCGTGTGCACTTACTTGGGCGAGTGGGTCAGGACCCTGTCTTGAG
ACAGGTGGAAGGAAAAAATCCAGTCACAATATTTTCTCTAGCAACTAATGAGATGTGGCGATCAGGGGATAGTGAAGTTTACCAACTGGG
TGATGTCAGTCAAAAGACAACATGGCACAGAATATCAGTATTCCGGCCAGGCCTCAGAGACGTGGCATATCAATATGTGAAAAAGGGAAA
TAGACTATGGTGAATACATGGATAAAAATAATGTGAGGCGACAAGCAACAACAATCATAGCTGGAGCGGGCGAGCGGCGACGGCGGCGGC
GGCGGGCACAGATTAATTAAAAGAAGAATGAACTATAATCCTTGAAGATAACTGGGCAATTTTTTAAGTCGGAGGCTGTTCTTACTGGTG
TGAGGATTTACACACGTCTTCAGTTTTTCAGCACAGACCAGCAGACCATCATTTTTAGAGGAAATACTCCCTCTGCCCTCCTTTTTGGTT
TCCTTGGTGGTAAAGATTAAATTTGGTTGCATCATTTTGACTTGTGTTTGAGTCTAGATTTTATGGCACAAGGAATGGCATAAACTTTTC
ATGTGTTTTGGTTAAAACAAACCAGACCATTGCATTGACCCTGGACATCTTTAATTGAGAAATTGGTAACTTTATTTTAATATGTATATC
TGAAGAATTCAAGAAAACAAAGGCATCCTCAGAGGTGTGCCTCTTTTCTTTATTATTAGAGGCAAAACGAACAATTTTATAGGATTTGTA
GTGAAATTATACCAGATTATAAGGAGAACCAAAACTAAGTCGCAAAATTTATTAATTTAAGGGGCTCTCGCTTTGAAAGTTTGAGAGTAA
GTTACGATAGGCATTTGTATCCATTCATTACTTTCCTCTTTTCAAATAAGCAACTAAATAGAAATGCTAATCTCAGACTTAATTATTTAA
CAGAAGAGTGTACCATGGAAAACCTCCAGACAAATTTCTCCTTGGTTCAGGGCTCAACTAAAAAACTGAATGGGATGGGAGATGATGGCA
GCCCCCCAGCGAAAAAAATGATAACGGACATTCATGCAAATGGAAAAACGATAAACAAGGTGCCAACAGTTAAGAAGGAACACTTGGATG
ACTATGGAGAAGCACCAGTGGAAACTGATGGAGAGCATGTTAAGCGAACCTGTACTTCTGTTCCTGAAACTTTGCATTTAAATCCCAGTT
TGAAACACACATTGGCACAATTCCATTTAAGTAGTCAGAGCTCGCTGGGTGGACCAGCAGCATTTTCTGCTCGGCATTCCCAAGAAAGCA
TGTCGCCTACTGTATTTCTGCCTCTTCCATCACCTCAGGTTCTTCCTGGCCCATTGCTCATCCCTTCAGATAGCTCCACAGAACTCACTC
AGACTGTGTTGGAAGGGGAATCTATTTCTTGTTTTCAAGTTGGAGGAGAAAAGAGACTCTGTTTGCCCCAAGTCTTAAATTCTGTTCTCC
GAGAATTTACACTCCAGCAAATAAATACAGTGTGTGATGAACTGTACATATATTGTTCAAGGTGTACTTCAGACCAGCTTCATATCTTAA
AGGTACTGGGCATACTTCCATTCAATGCCCCATCCTGTGGGCTGATTACATTAACTGATGCACAAAGATTATGTAATGCTTTATTGCGGC
CACGAACTTTTCCTCAAAATGGTAGCGTACTTCCTGCTAAAAGCTCATTGGCCCAGTTAAAGGAAACTGGCAGTGCCTTTGAAGTGGAGC
ATGAATGCCTAGGCAAATGTCAGGGTTTATTTGCACCCCAGTTTTATGTTCAGCCTGATGCTCCGTGTATTCAATGTCTGGAGTGTTGTG
GAATGTTTGCACCCCAGACGTTTGTGATGCATTCTCACAGATCACCTGACAAAAGAACTTGCCACTGGGGCTTTGAATCAGCTAAATGGC
ATTGCTATCTTCATGTGAACCAAAAATACTTAGGAACACCTGAAGAAAAGAAACTGAAGATAATTTTAGAAGAAATGAAGGAGAAGTTTA
GCATGAGAAGTGGAAAGAGAAATCAATCCAAGACAGATGCACCATCAGGAATGGAATTACAGTCATGGTATCCTGTTATAAAGCAGGAAG
GTGACCATGTTTCTCAGACACATTCATTTTTACACCCCAGCTACTACTTATACATGTGTGATAAAGTGGTTGCCCCAAATGTGTCACTTA
CTTCTGCTGTATCCCAGTCTAAAGAGCTCACAAAGACAGAGGCAAGTAAGTCCATATCAAGACAGTCAGAGAAGGCTCACAGTAGTGGTA
AACTTCAAAAAACAGTGTCTTATCCAGATGTCTCACTTGAGGAACAGGAGAAAATGGATTTAAAAACAAGTAGAGAATTATGTAGCCGTT
TAGATGCATCAATCTCAAATAATTCTACAAGTAAAAGGAAATCTGAGTCTGCCACTTGCAACTTAGTCAGAGACATAAACAAAGTGGGAA
TTGGCCTTGTTGCTGCCGCTTCATCTCCGCTTCTTGTGAAAGATGTCATTTGTGAGGATGATAAGGGAAAAATCATGGAAGAAGTAATGA
GAACTTATTTAAAACAACAGGAAAAACTAAACTTGATTTTGCAAAAGAAGCAACAACTTCAGATGGAAGTAAAAATGTTGAGTAGTTCAA
AATCTATGAAGGAACTCACTGAAGAACAGCAGAATTTACAGAAAGAGCTTGAATCTTTGCAGAATGAACATGCTCAAAGAATGGAAGAAT
TTTATGTTGAACAGAAAGACTTAGAGAAAAAATTGGAGCAGATAATGAAGCAAAAATGTACCTGTGACTCAAATTTAGAAAAAGACAAAG
AGGCTGAATATGCAGGACAGTTGGCAGAACTGAGGCAGAGATTGGACCATGCTGAGGCCGATAGGCAAGAACTCCAAGATGAACTCAGAC
AGGAACGGGAAGCAAGACAGAAGTTAGAGATGATGATAAAAGAGCTAAAGCTGCAAATTCTGAAATCATCAAAGACTGCTAAAGAATAGA
AACTGTTAAAGAGATTCATCTGTGTATTACTGACAAGGTTTTTTTTGTTTGTTGCTTGCTTTGGTAATTGAATTCTGAAGAATTTATCTG
CATGACGATAACTAGGCATTCTATCCATTTGTAGATCAGAGAAAGTGAAGAGATTATATATTAGTACTTAAATTTTTACATTTTCCAAAT
GAATGAAAATGTATGTTTCTTTGTACTTTTTTAAAAAAATCAGCTTAGTAACAATACTATATGGTTTCAACTAGTAGGTAATCTGCTTAT

>86705_86705_1_SSBP1-SKIL_SSBP1_chr7_141445318_ENST00000265304_SKIL_chr3_170075509_ENST00000259119_length(amino acids)=722AA_BP=
MRVSYDRHLYPFITFLFSNKQLNRNANLRLNYLTEECTMENLQTNFSLVQGSTKKLNGMGDDGSPPAKKMITDIHANGKTINKVPTVKKE
HLDDYGEAPVETDGEHVKRTCTSVPETLHLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTVFLPLPSPQVLPGPLLIPSDSST
ELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNA
LLRPRTFPQNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGFES
AKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPN
VSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDIN
KVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQR
MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTA

--------------------------------------------------------------
>86705_86705_2_SSBP1-SKIL_SSBP1_chr7_141445318_ENST00000465582_SKIL_chr3_170075509_ENST00000259119_length(transcript)=3491nt_BP=434nt
TAGATCGTCAGGAAAAGCCTAAAGATTAGACTGTAAGAAAAGAAAATAGAAGCCATGTTTCGAAGACCTGTATTACAGGTACTTCGTCAG
TTTGTAAGACATGAGTCCGAAACAACTACCAGTTTGGTTCTTGAAAGATCCCTGAATCGTGTGCACTTACTTGGGCGAGTGGGTCAGGAC
CCTGTCTTGAGACAGGTGGAAGGAAAAAATCCAGTCACAATATTTTCTCTAGCAACTAATGAGATGTGGCGATCAGGGGATAGTGAAGTT
TACCAACTGGGTGATGTCAGTCAAAAGACAACATGGCACAGAATATCAGTATTCCGGCCAGGCCTCAGAGACGTGGCATATCAATATGTG
AAAAAGGGAAATAGACTATGGTGAATACATGGATAAAAATAATGTGAGGCGACAAGCAACAACAATCATAGCTGGAGCGGGCGAGCGGCG
ACGGCGGCGGCGGCGGGCACAGATTAATTAAAAGAAGAATGAACTATAATCCTTGAAGATAACTGGGCAATTTTTTAAGTCGGAGGCTGT
TCTTACTGGTGTGAGGATTTACACACGTCTTCAGTTTTTCAGCACAGACCAGCAGACCATCATTTTTAGAGGAAATACTCCCTCTGCCCT
CCTTTTTGGTTTCCTTGGTGGTAAAGATTAAATTTGGTTGCATCATTTTGACTTGTGTTTGAGTCTAGATTTTATGGCACAAGGAATGGC
ATAAACTTTTCATGTGTTTTGGTTAAAACAAACCAGACCATTGCATTGACCCTGGACATCTTTAATTGAGAAATTGGTAACTTTATTTTA
ATATGTATATCTGAAGAATTCAAGAAAACAAAGGCATCCTCAGAGGTGTGCCTCTTTTCTTTATTATTAGAGGCAAAACGAACAATTTTA
TAGGATTTGTAGTGAAATTATACCAGATTATAAGGAGAACCAAAACTAAGTCGCAAAATTTATTAATTTAAGGGGCTCTCGCTTTGAAAG
TTTGAGAGTAAGTTACGATAGGCATTTGTATCCATTCATTACTTTCCTCTTTTCAAATAAGCAACTAAATAGAAATGCTAATCTCAGACT
TAATTATTTAACAGAAGAGTGTACCATGGAAAACCTCCAGACAAATTTCTCCTTGGTTCAGGGCTCAACTAAAAAACTGAATGGGATGGG
AGATGATGGCAGCCCCCCAGCGAAAAAAATGATAACGGACATTCATGCAAATGGAAAAACGATAAACAAGGTGCCAACAGTTAAGAAGGA
ACACTTGGATGACTATGGAGAAGCACCAGTGGAAACTGATGGAGAGCATGTTAAGCGAACCTGTACTTCTGTTCCTGAAACTTTGCATTT
AAATCCCAGTTTGAAACACACATTGGCACAATTCCATTTAAGTAGTCAGAGCTCGCTGGGTGGACCAGCAGCATTTTCTGCTCGGCATTC
CCAAGAAAGCATGTCGCCTACTGTATTTCTGCCTCTTCCATCACCTCAGGTTCTTCCTGGCCCATTGCTCATCCCTTCAGATAGCTCCAC
AGAACTCACTCAGACTGTGTTGGAAGGGGAATCTATTTCTTGTTTTCAAGTTGGAGGAGAAAAGAGACTCTGTTTGCCCCAAGTCTTAAA
TTCTGTTCTCCGAGAATTTACACTCCAGCAAATAAATACAGTGTGTGATGAACTGTACATATATTGTTCAAGGTGTACTTCAGACCAGCT
TCATATCTTAAAGGTACTGGGCATACTTCCATTCAATGCCCCATCCTGTGGGCTGATTACATTAACTGATGCACAAAGATTATGTAATGC
TTTATTGCGGCCACGAACTTTTCCTCAAAATGGTAGCGTACTTCCTGCTAAAAGCTCATTGGCCCAGTTAAAGGAAACTGGCAGTGCCTT
TGAAGTGGAGCATGAATGCCTAGGCAAATGTCAGGGTTTATTTGCACCCCAGTTTTATGTTCAGCCTGATGCTCCGTGTATTCAATGTCT
GGAGTGTTGTGGAATGTTTGCACCCCAGACGTTTGTGATGCATTCTCACAGATCACCTGACAAAAGAACTTGCCACTGGGGCTTTGAATC
AGCTAAATGGCATTGCTATCTTCATGTGAACCAAAAATACTTAGGAACACCTGAAGAAAAGAAACTGAAGATAATTTTAGAAGAAATGAA
GGAGAAGTTTAGCATGAGAAGTGGAAAGAGAAATCAATCCAAGACAGATGCACCATCAGGAATGGAATTACAGTCATGGTATCCTGTTAT
AAAGCAGGAAGGTGACCATGTTTCTCAGACACATTCATTTTTACACCCCAGCTACTACTTATACATGTGTGATAAAGTGGTTGCCCCAAA
TGTGTCACTTACTTCTGCTGTATCCCAGTCTAAAGAGCTCACAAAGACAGAGGCAAGTAAGTCCATATCAAGACAGTCAGAGAAGGCTCA
CAGTAGTGGTAAACTTCAAAAAACAGTGTCTTATCCAGATGTCTCACTTGAGGAACAGGAGAAAATGGATTTAAAAACAAGTAGAGAATT
ATGTAGCCGTTTAGATGCATCAATCTCAAATAATTCTACAAGTAAAAGGAAATCTGAGTCTGCCACTTGCAACTTAGTCAGAGACATAAA
CAAAGTGGGAATTGGCCTTGTTGCTGCCGCTTCATCTCCGCTTCTTGTGAAAGATGTCATTTGTGAGGATGATAAGGGAAAAATCATGGA
AGAAGTAATGAGAACTTATTTAAAACAACAGGAAAAACTAAACTTGATTTTGCAAAAGAAGCAACAACTTCAGATGGAAGTAAAAATGTT
GAGTAGTTCAAAATCTATGAAGGAACTCACTGAAGAACAGCAGAATTTACAGAAAGAGCTTGAATCTTTGCAGAATGAACATGCTCAAAG
AATGGAAGAATTTTATGTTGAACAGAAAGACTTAGAGAAAAAATTGGAGCAGATAATGAAGCAAAAATGTACCTGTGACTCAAATTTAGA
AAAAGACAAAGAGGCTGAATATGCAGGACAGTTGGCAGAACTGAGGCAGAGATTGGACCATGCTGAGGCCGATAGGCAAGAACTCCAAGA
TGAACTCAGACAGGAACGGGAAGCAAGACAGAAGTTAGAGATGATGATAAAAGAGCTAAAGCTGCAAATTCTGAAATCATCAAAGACTGC
TAAAGAATAGAAACTGTTAAAGAGATTCATCTGTGTATTACTGACAAGGTTTTTTTTGTTTGTTGCTTGCTTTGGTAATTGAATTCTGAA
GAATTTATCTGCATGACGATAACTAGGCATTCTATCCATTTGTAGATCAGAGAAAGTGAAGAGATTATATATTAGTACTTAAATTTTTAC
ATTTTCCAAATGAATGAAAATGTATGTTTCTTTGTACTTTTTTAAAAAAATCAGCTTAGTAACAATACTATATGGTTTCAACTAGTAGGT

>86705_86705_2_SSBP1-SKIL_SSBP1_chr7_141445318_ENST00000465582_SKIL_chr3_170075509_ENST00000259119_length(amino acids)=722AA_BP=
MRVSYDRHLYPFITFLFSNKQLNRNANLRLNYLTEECTMENLQTNFSLVQGSTKKLNGMGDDGSPPAKKMITDIHANGKTINKVPTVKKE
HLDDYGEAPVETDGEHVKRTCTSVPETLHLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTVFLPLPSPQVLPGPLLIPSDSST
ELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNA
LLRPRTFPQNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGFES
AKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPN
VSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDIN
KVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQR
MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTA

--------------------------------------------------------------
>86705_86705_3_SSBP1-SKIL_SSBP1_chr7_141445318_ENST00000481508_SKIL_chr3_170075509_ENST00000259119_length(transcript)=3872nt_BP=815nt
ACCTCTCCCTATGGTGTGGCTGGCTAGCCCGGGGGTCTCTACGCTGCTTGGTCTTTGTTAACGGAGATGAAGGCAGTAATTTTTCAGTAA
CAGGTTTCAGATATAAGTCCCTTGGTGATGCTAATATTTATGGAGGCCTTACTATGCATTAAGAACTTTTTTAGAAGTTTAGAAAATGGC
AGTGAATAAAGCAGATACAAATCTCTGCTCTAAGGGAGCTTGCATAGTAATGAAATTTGAGAAGACAGTGGATTGGAAGTGGGATTAACT
CAGAATCAAAATTTTGTCGATGGGTTGGAGGAAGAGGAAGTTATTTGGGACCAAAAAGACATACAGGTGTGAGTTTATTTGGGAGGGAGG
AAGGAATCCTCATCAGATGTGCAGGAATGTTGGAAAAGCCTAAAGATTAGACTGTAAGAAAAGAAAATAGAAGCCATGTTTCGAAGACCT
GTATTACAGGTACTTCGTCAGTTTGTAAGACATGAGTCCGAAACAACTACCAGTTTGGTTCTTGAAAGATCCCTGAATCGTGTGCACTTA
CTTGGGCGAGTGGGTCAGGACCCTGTCTTGAGACAGGTGGAAGGAAAAAATCCAGTCACAATATTTTCTCTAGCAACTAATGAGATGTGG
CGATCAGGGGATAGTGAAGTTTACCAACTGGGTGATGTCAGTCAAAAGACAACATGGCACAGAATATCAGTATTCCGGCCAGGCCTCAGA
GACGTGGCATATCAATATGTGAAAAAGGGAAATAGACTATGGTGAATACATGGATAAAAATAATGTGAGGCGACAAGCAACAACAATCAT
AGCTGGAGCGGGCGAGCGGCGACGGCGGCGGCGGCGGGCACAGATTAATTAAAAGAAGAATGAACTATAATCCTTGAAGATAACTGGGCA
ATTTTTTAAGTCGGAGGCTGTTCTTACTGGTGTGAGGATTTACACACGTCTTCAGTTTTTCAGCACAGACCAGCAGACCATCATTTTTAG
AGGAAATACTCCCTCTGCCCTCCTTTTTGGTTTCCTTGGTGGTAAAGATTAAATTTGGTTGCATCATTTTGACTTGTGTTTGAGTCTAGA
TTTTATGGCACAAGGAATGGCATAAACTTTTCATGTGTTTTGGTTAAAACAAACCAGACCATTGCATTGACCCTGGACATCTTTAATTGA
GAAATTGGTAACTTTATTTTAATATGTATATCTGAAGAATTCAAGAAAACAAAGGCATCCTCAGAGGTGTGCCTCTTTTCTTTATTATTA
GAGGCAAAACGAACAATTTTATAGGATTTGTAGTGAAATTATACCAGATTATAAGGAGAACCAAAACTAAGTCGCAAAATTTATTAATTT
AAGGGGCTCTCGCTTTGAAAGTTTGAGAGTAAGTTACGATAGGCATTTGTATCCATTCATTACTTTCCTCTTTTCAAATAAGCAACTAAA
TAGAAATGCTAATCTCAGACTTAATTATTTAACAGAAGAGTGTACCATGGAAAACCTCCAGACAAATTTCTCCTTGGTTCAGGGCTCAAC
TAAAAAACTGAATGGGATGGGAGATGATGGCAGCCCCCCAGCGAAAAAAATGATAACGGACATTCATGCAAATGGAAAAACGATAAACAA
GGTGCCAACAGTTAAGAAGGAACACTTGGATGACTATGGAGAAGCACCAGTGGAAACTGATGGAGAGCATGTTAAGCGAACCTGTACTTC
TGTTCCTGAAACTTTGCATTTAAATCCCAGTTTGAAACACACATTGGCACAATTCCATTTAAGTAGTCAGAGCTCGCTGGGTGGACCAGC
AGCATTTTCTGCTCGGCATTCCCAAGAAAGCATGTCGCCTACTGTATTTCTGCCTCTTCCATCACCTCAGGTTCTTCCTGGCCCATTGCT
CATCCCTTCAGATAGCTCCACAGAACTCACTCAGACTGTGTTGGAAGGGGAATCTATTTCTTGTTTTCAAGTTGGAGGAGAAAAGAGACT
CTGTTTGCCCCAAGTCTTAAATTCTGTTCTCCGAGAATTTACACTCCAGCAAATAAATACAGTGTGTGATGAACTGTACATATATTGTTC
AAGGTGTACTTCAGACCAGCTTCATATCTTAAAGGTACTGGGCATACTTCCATTCAATGCCCCATCCTGTGGGCTGATTACATTAACTGA
TGCACAAAGATTATGTAATGCTTTATTGCGGCCACGAACTTTTCCTCAAAATGGTAGCGTACTTCCTGCTAAAAGCTCATTGGCCCAGTT
AAAGGAAACTGGCAGTGCCTTTGAAGTGGAGCATGAATGCCTAGGCAAATGTCAGGGTTTATTTGCACCCCAGTTTTATGTTCAGCCTGA
TGCTCCGTGTATTCAATGTCTGGAGTGTTGTGGAATGTTTGCACCCCAGACGTTTGTGATGCATTCTCACAGATCACCTGACAAAAGAAC
TTGCCACTGGGGCTTTGAATCAGCTAAATGGCATTGCTATCTTCATGTGAACCAAAAATACTTAGGAACACCTGAAGAAAAGAAACTGAA
GATAATTTTAGAAGAAATGAAGGAGAAGTTTAGCATGAGAAGTGGAAAGAGAAATCAATCCAAGACAGATGCACCATCAGGAATGGAATT
ACAGTCATGGTATCCTGTTATAAAGCAGGAAGGTGACCATGTTTCTCAGACACATTCATTTTTACACCCCAGCTACTACTTATACATGTG
TGATAAAGTGGTTGCCCCAAATGTGTCACTTACTTCTGCTGTATCCCAGTCTAAAGAGCTCACAAAGACAGAGGCAAGTAAGTCCATATC
AAGACAGTCAGAGAAGGCTCACAGTAGTGGTAAACTTCAAAAAACAGTGTCTTATCCAGATGTCTCACTTGAGGAACAGGAGAAAATGGA
TTTAAAAACAAGTAGAGAATTATGTAGCCGTTTAGATGCATCAATCTCAAATAATTCTACAAGTAAAAGGAAATCTGAGTCTGCCACTTG
CAACTTAGTCAGAGACATAAACAAAGTGGGAATTGGCCTTGTTGCTGCCGCTTCATCTCCGCTTCTTGTGAAAGATGTCATTTGTGAGGA
TGATAAGGGAAAAATCATGGAAGAAGTAATGAGAACTTATTTAAAACAACAGGAAAAACTAAACTTGATTTTGCAAAAGAAGCAACAACT
TCAGATGGAAGTAAAAATGTTGAGTAGTTCAAAATCTATGAAGGAACTCACTGAAGAACAGCAGAATTTACAGAAAGAGCTTGAATCTTT
GCAGAATGAACATGCTCAAAGAATGGAAGAATTTTATGTTGAACAGAAAGACTTAGAGAAAAAATTGGAGCAGATAATGAAGCAAAAATG
TACCTGTGACTCAAATTTAGAAAAAGACAAAGAGGCTGAATATGCAGGACAGTTGGCAGAACTGAGGCAGAGATTGGACCATGCTGAGGC
CGATAGGCAAGAACTCCAAGATGAACTCAGACAGGAACGGGAAGCAAGACAGAAGTTAGAGATGATGATAAAAGAGCTAAAGCTGCAAAT
TCTGAAATCATCAAAGACTGCTAAAGAATAGAAACTGTTAAAGAGATTCATCTGTGTATTACTGACAAGGTTTTTTTTGTTTGTTGCTTG
CTTTGGTAATTGAATTCTGAAGAATTTATCTGCATGACGATAACTAGGCATTCTATCCATTTGTAGATCAGAGAAAGTGAAGAGATTATA
TATTAGTACTTAAATTTTTACATTTTCCAAATGAATGAAAATGTATGTTTCTTTGTACTTTTTTAAAAAAATCAGCTTAGTAACAATACT
ATATGGTTTCAACTAGTAGGTAATCTGCTTATATTTCTAATGCAAACTTAACAATTGTGTACTTTTTAAAAGCTGCAATATGTGTTGGAA

>86705_86705_3_SSBP1-SKIL_SSBP1_chr7_141445318_ENST00000481508_SKIL_chr3_170075509_ENST00000259119_length(amino acids)=722AA_BP=
MRVSYDRHLYPFITFLFSNKQLNRNANLRLNYLTEECTMENLQTNFSLVQGSTKKLNGMGDDGSPPAKKMITDIHANGKTINKVPTVKKE
HLDDYGEAPVETDGEHVKRTCTSVPETLHLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTVFLPLPSPQVLPGPLLIPSDSST
ELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNA
LLRPRTFPQNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGFES
AKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPN
VSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDIN
KVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQR
MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTA

--------------------------------------------------------------
>86705_86705_4_SSBP1-SKIL_SSBP1_chr7_141445318_ENST00000484178_SKIL_chr3_170075509_ENST00000259119_length(transcript)=3559nt_BP=502nt
GGTGTCCACCTCTCCCTATGGTGTGGCTGGCTAGCCCGGGGGTCTCTACGCTGCTTGGTCTTTGTTAACGGAGATGAAGGAAAAGCCTAA
AGATTAGACTGTAAGAAAAGAAAATAGAAGCCATGTTTCGAAGACCTGTATTACAGGTACTTCGTCAGTTTGTAAGACATGAGTCCGAAA
CAACTACCAGTTTGGTTCTTGAAAGATCCCTGAATCGTGTGCACTTACTTGGGCGAGTGGGTCAGGACCCTGTCTTGAGACAGGTGGAAG
GAAAAAATCCAGTCACAATATTTTCTCTAGCAACTAATGAGATGTGGCGATCAGGGGATAGTGAAGTTTACCAACTGGGTGATGTCAGTC
AAAAGACAACATGGCACAGAATATCAGTATTCCGGCCAGGCCTCAGAGACGTGGCATATCAATATGTGAAAAAGGGAAATAGACTATGGT
GAATACATGGATAAAAATAATGTGAGGCGACAAGCAACAACAATCATAGCTGGAGCGGGCGAGCGGCGACGGCGGCGGCGGCGGGCACAG
ATTAATTAAAAGAAGAATGAACTATAATCCTTGAAGATAACTGGGCAATTTTTTAAGTCGGAGGCTGTTCTTACTGGTGTGAGGATTTAC
ACACGTCTTCAGTTTTTCAGCACAGACCAGCAGACCATCATTTTTAGAGGAAATACTCCCTCTGCCCTCCTTTTTGGTTTCCTTGGTGGT
AAAGATTAAATTTGGTTGCATCATTTTGACTTGTGTTTGAGTCTAGATTTTATGGCACAAGGAATGGCATAAACTTTTCATGTGTTTTGG
TTAAAACAAACCAGACCATTGCATTGACCCTGGACATCTTTAATTGAGAAATTGGTAACTTTATTTTAATATGTATATCTGAAGAATTCA
AGAAAACAAAGGCATCCTCAGAGGTGTGCCTCTTTTCTTTATTATTAGAGGCAAAACGAACAATTTTATAGGATTTGTAGTGAAATTATA
CCAGATTATAAGGAGAACCAAAACTAAGTCGCAAAATTTATTAATTTAAGGGGCTCTCGCTTTGAAAGTTTGAGAGTAAGTTACGATAGG
CATTTGTATCCATTCATTACTTTCCTCTTTTCAAATAAGCAACTAAATAGAAATGCTAATCTCAGACTTAATTATTTAACAGAAGAGTGT
ACCATGGAAAACCTCCAGACAAATTTCTCCTTGGTTCAGGGCTCAACTAAAAAACTGAATGGGATGGGAGATGATGGCAGCCCCCCAGCG
AAAAAAATGATAACGGACATTCATGCAAATGGAAAAACGATAAACAAGGTGCCAACAGTTAAGAAGGAACACTTGGATGACTATGGAGAA
GCACCAGTGGAAACTGATGGAGAGCATGTTAAGCGAACCTGTACTTCTGTTCCTGAAACTTTGCATTTAAATCCCAGTTTGAAACACACA
TTGGCACAATTCCATTTAAGTAGTCAGAGCTCGCTGGGTGGACCAGCAGCATTTTCTGCTCGGCATTCCCAAGAAAGCATGTCGCCTACT
GTATTTCTGCCTCTTCCATCACCTCAGGTTCTTCCTGGCCCATTGCTCATCCCTTCAGATAGCTCCACAGAACTCACTCAGACTGTGTTG
GAAGGGGAATCTATTTCTTGTTTTCAAGTTGGAGGAGAAAAGAGACTCTGTTTGCCCCAAGTCTTAAATTCTGTTCTCCGAGAATTTACA
CTCCAGCAAATAAATACAGTGTGTGATGAACTGTACATATATTGTTCAAGGTGTACTTCAGACCAGCTTCATATCTTAAAGGTACTGGGC
ATACTTCCATTCAATGCCCCATCCTGTGGGCTGATTACATTAACTGATGCACAAAGATTATGTAATGCTTTATTGCGGCCACGAACTTTT
CCTCAAAATGGTAGCGTACTTCCTGCTAAAAGCTCATTGGCCCAGTTAAAGGAAACTGGCAGTGCCTTTGAAGTGGAGCATGAATGCCTA
GGCAAATGTCAGGGTTTATTTGCACCCCAGTTTTATGTTCAGCCTGATGCTCCGTGTATTCAATGTCTGGAGTGTTGTGGAATGTTTGCA
CCCCAGACGTTTGTGATGCATTCTCACAGATCACCTGACAAAAGAACTTGCCACTGGGGCTTTGAATCAGCTAAATGGCATTGCTATCTT
CATGTGAACCAAAAATACTTAGGAACACCTGAAGAAAAGAAACTGAAGATAATTTTAGAAGAAATGAAGGAGAAGTTTAGCATGAGAAGT
GGAAAGAGAAATCAATCCAAGACAGATGCACCATCAGGAATGGAATTACAGTCATGGTATCCTGTTATAAAGCAGGAAGGTGACCATGTT
TCTCAGACACATTCATTTTTACACCCCAGCTACTACTTATACATGTGTGATAAAGTGGTTGCCCCAAATGTGTCACTTACTTCTGCTGTA
TCCCAGTCTAAAGAGCTCACAAAGACAGAGGCAAGTAAGTCCATATCAAGACAGTCAGAGAAGGCTCACAGTAGTGGTAAACTTCAAAAA
ACAGTGTCTTATCCAGATGTCTCACTTGAGGAACAGGAGAAAATGGATTTAAAAACAAGTAGAGAATTATGTAGCCGTTTAGATGCATCA
ATCTCAAATAATTCTACAAGTAAAAGGAAATCTGAGTCTGCCACTTGCAACTTAGTCAGAGACATAAACAAAGTGGGAATTGGCCTTGTT
GCTGCCGCTTCATCTCCGCTTCTTGTGAAAGATGTCATTTGTGAGGATGATAAGGGAAAAATCATGGAAGAAGTAATGAGAACTTATTTA
AAACAACAGGAAAAACTAAACTTGATTTTGCAAAAGAAGCAACAACTTCAGATGGAAGTAAAAATGTTGAGTAGTTCAAAATCTATGAAG
GAACTCACTGAAGAACAGCAGAATTTACAGAAAGAGCTTGAATCTTTGCAGAATGAACATGCTCAAAGAATGGAAGAATTTTATGTTGAA
CAGAAAGACTTAGAGAAAAAATTGGAGCAGATAATGAAGCAAAAATGTACCTGTGACTCAAATTTAGAAAAAGACAAAGAGGCTGAATAT
GCAGGACAGTTGGCAGAACTGAGGCAGAGATTGGACCATGCTGAGGCCGATAGGCAAGAACTCCAAGATGAACTCAGACAGGAACGGGAA
GCAAGACAGAAGTTAGAGATGATGATAAAAGAGCTAAAGCTGCAAATTCTGAAATCATCAAAGACTGCTAAAGAATAGAAACTGTTAAAG
AGATTCATCTGTGTATTACTGACAAGGTTTTTTTTGTTTGTTGCTTGCTTTGGTAATTGAATTCTGAAGAATTTATCTGCATGACGATAA
CTAGGCATTCTATCCATTTGTAGATCAGAGAAAGTGAAGAGATTATATATTAGTACTTAAATTTTTACATTTTCCAAATGAATGAAAATG
TATGTTTCTTTGTACTTTTTTAAAAAAATCAGCTTAGTAACAATACTATATGGTTTCAACTAGTAGGTAATCTGCTTATATTTCTAATGC

>86705_86705_4_SSBP1-SKIL_SSBP1_chr7_141445318_ENST00000484178_SKIL_chr3_170075509_ENST00000259119_length(amino acids)=722AA_BP=
MRVSYDRHLYPFITFLFSNKQLNRNANLRLNYLTEECTMENLQTNFSLVQGSTKKLNGMGDDGSPPAKKMITDIHANGKTINKVPTVKKE
HLDDYGEAPVETDGEHVKRTCTSVPETLHLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTVFLPLPSPQVLPGPLLIPSDSST
ELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNA
LLRPRTFPQNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGFES
AKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPN
VSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDIN
KVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQR
MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTA

--------------------------------------------------------------
>86705_86705_5_SSBP1-SKIL_SSBP1_chr7_141445318_ENST00000498107_SKIL_chr3_170075509_ENST00000259119_length(transcript)=3626nt_BP=569nt
GTGCGCCGGAAGTGATCCCCTGCGTGGCTGGGCTGCTCGGGTTAGATCGTCAGGTGAGGGAGGAAGGGATAGCCAGCGCGAAGGAAGTGC
TGGAGTCGTGTGTTTTGGCTGCGCGTGATCCTGCGTGGGTCGGGAGGTGTTTCTGTGAAAAGCCTAAAGATTAGACTGTAAGAAAAGAAA
ATAGAAGCCATGTTTCGAAGACCTGTATTACAGGTACTTCGTCAGTTTGTAAGACATGAGTCCGAAACAACTACCAGTTTGGTTCTTGAA
AGATCCCTGAATCGTGTGCACTTACTTGGGCGAGTGGGTCAGGACCCTGTCTTGAGACAGGTGGAAGGAAAAAATCCAGTCACAATATTT
TCTCTAGCAACTAATGAGATGTGGCGATCAGGGGATAGTGAAGTTTACCAACTGGGTGATGTCAGTCAAAAGACAACATGGCACAGAATA
TCAGTATTCCGGCCAGGCCTCAGAGACGTGGCATATCAATATGTGAAAAAGGGAAATAGACTATGGTGAATACATGGATAAAAATAATGT
GAGGCGACAAGCAACAACAATCATAGCTGGAGCGGGCGAGCGGCGACGGCGGCGGCGGCGGGCACAGATTAATTAAAAGAAGAATGAACT
ATAATCCTTGAAGATAACTGGGCAATTTTTTAAGTCGGAGGCTGTTCTTACTGGTGTGAGGATTTACACACGTCTTCAGTTTTTCAGCAC
AGACCAGCAGACCATCATTTTTAGAGGAAATACTCCCTCTGCCCTCCTTTTTGGTTTCCTTGGTGGTAAAGATTAAATTTGGTTGCATCA
TTTTGACTTGTGTTTGAGTCTAGATTTTATGGCACAAGGAATGGCATAAACTTTTCATGTGTTTTGGTTAAAACAAACCAGACCATTGCA
TTGACCCTGGACATCTTTAATTGAGAAATTGGTAACTTTATTTTAATATGTATATCTGAAGAATTCAAGAAAACAAAGGCATCCTCAGAG
GTGTGCCTCTTTTCTTTATTATTAGAGGCAAAACGAACAATTTTATAGGATTTGTAGTGAAATTATACCAGATTATAAGGAGAACCAAAA
CTAAGTCGCAAAATTTATTAATTTAAGGGGCTCTCGCTTTGAAAGTTTGAGAGTAAGTTACGATAGGCATTTGTATCCATTCATTACTTT
CCTCTTTTCAAATAAGCAACTAAATAGAAATGCTAATCTCAGACTTAATTATTTAACAGAAGAGTGTACCATGGAAAACCTCCAGACAAA
TTTCTCCTTGGTTCAGGGCTCAACTAAAAAACTGAATGGGATGGGAGATGATGGCAGCCCCCCAGCGAAAAAAATGATAACGGACATTCA
TGCAAATGGAAAAACGATAAACAAGGTGCCAACAGTTAAGAAGGAACACTTGGATGACTATGGAGAAGCACCAGTGGAAACTGATGGAGA
GCATGTTAAGCGAACCTGTACTTCTGTTCCTGAAACTTTGCATTTAAATCCCAGTTTGAAACACACATTGGCACAATTCCATTTAAGTAG
TCAGAGCTCGCTGGGTGGACCAGCAGCATTTTCTGCTCGGCATTCCCAAGAAAGCATGTCGCCTACTGTATTTCTGCCTCTTCCATCACC
TCAGGTTCTTCCTGGCCCATTGCTCATCCCTTCAGATAGCTCCACAGAACTCACTCAGACTGTGTTGGAAGGGGAATCTATTTCTTGTTT
TCAAGTTGGAGGAGAAAAGAGACTCTGTTTGCCCCAAGTCTTAAATTCTGTTCTCCGAGAATTTACACTCCAGCAAATAAATACAGTGTG
TGATGAACTGTACATATATTGTTCAAGGTGTACTTCAGACCAGCTTCATATCTTAAAGGTACTGGGCATACTTCCATTCAATGCCCCATC
CTGTGGGCTGATTACATTAACTGATGCACAAAGATTATGTAATGCTTTATTGCGGCCACGAACTTTTCCTCAAAATGGTAGCGTACTTCC
TGCTAAAAGCTCATTGGCCCAGTTAAAGGAAACTGGCAGTGCCTTTGAAGTGGAGCATGAATGCCTAGGCAAATGTCAGGGTTTATTTGC
ACCCCAGTTTTATGTTCAGCCTGATGCTCCGTGTATTCAATGTCTGGAGTGTTGTGGAATGTTTGCACCCCAGACGTTTGTGATGCATTC
TCACAGATCACCTGACAAAAGAACTTGCCACTGGGGCTTTGAATCAGCTAAATGGCATTGCTATCTTCATGTGAACCAAAAATACTTAGG
AACACCTGAAGAAAAGAAACTGAAGATAATTTTAGAAGAAATGAAGGAGAAGTTTAGCATGAGAAGTGGAAAGAGAAATCAATCCAAGAC
AGATGCACCATCAGGAATGGAATTACAGTCATGGTATCCTGTTATAAAGCAGGAAGGTGACCATGTTTCTCAGACACATTCATTTTTACA
CCCCAGCTACTACTTATACATGTGTGATAAAGTGGTTGCCCCAAATGTGTCACTTACTTCTGCTGTATCCCAGTCTAAAGAGCTCACAAA
GACAGAGGCAAGTAAGTCCATATCAAGACAGTCAGAGAAGGCTCACAGTAGTGGTAAACTTCAAAAAACAGTGTCTTATCCAGATGTCTC
ACTTGAGGAACAGGAGAAAATGGATTTAAAAACAAGTAGAGAATTATGTAGCCGTTTAGATGCATCAATCTCAAATAATTCTACAAGTAA
AAGGAAATCTGAGTCTGCCACTTGCAACTTAGTCAGAGACATAAACAAAGTGGGAATTGGCCTTGTTGCTGCCGCTTCATCTCCGCTTCT
TGTGAAAGATGTCATTTGTGAGGATGATAAGGGAAAAATCATGGAAGAAGTAATGAGAACTTATTTAAAACAACAGGAAAAACTAAACTT
GATTTTGCAAAAGAAGCAACAACTTCAGATGGAAGTAAAAATGTTGAGTAGTTCAAAATCTATGAAGGAACTCACTGAAGAACAGCAGAA
TTTACAGAAAGAGCTTGAATCTTTGCAGAATGAACATGCTCAAAGAATGGAAGAATTTTATGTTGAACAGAAAGACTTAGAGAAAAAATT
GGAGCAGATAATGAAGCAAAAATGTACCTGTGACTCAAATTTAGAAAAAGACAAAGAGGCTGAATATGCAGGACAGTTGGCAGAACTGAG
GCAGAGATTGGACCATGCTGAGGCCGATAGGCAAGAACTCCAAGATGAACTCAGACAGGAACGGGAAGCAAGACAGAAGTTAGAGATGAT
GATAAAAGAGCTAAAGCTGCAAATTCTGAAATCATCAAAGACTGCTAAAGAATAGAAACTGTTAAAGAGATTCATCTGTGTATTACTGAC
AAGGTTTTTTTTGTTTGTTGCTTGCTTTGGTAATTGAATTCTGAAGAATTTATCTGCATGACGATAACTAGGCATTCTATCCATTTGTAG
ATCAGAGAAAGTGAAGAGATTATATATTAGTACTTAAATTTTTACATTTTCCAAATGAATGAAAATGTATGTTTCTTTGTACTTTTTTAA
AAAAATCAGCTTAGTAACAATACTATATGGTTTCAACTAGTAGGTAATCTGCTTATATTTCTAATGCAAACTTAACAATTGTGTACTTTT

>86705_86705_5_SSBP1-SKIL_SSBP1_chr7_141445318_ENST00000498107_SKIL_chr3_170075509_ENST00000259119_length(amino acids)=722AA_BP=
MRVSYDRHLYPFITFLFSNKQLNRNANLRLNYLTEECTMENLQTNFSLVQGSTKKLNGMGDDGSPPAKKMITDIHANGKTINKVPTVKKE
HLDDYGEAPVETDGEHVKRTCTSVPETLHLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTVFLPLPSPQVLPGPLLIPSDSST
ELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNA
LLRPRTFPQNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGFES
AKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSGKRNQSKTDAPSGMELQSWYPVIKQEGDHVSQTHSFLHPSYYLYMCDKVVAPN
VSLTSAVSQSKELTKTEASKSISRQSEKAHSSGKLQKTVSYPDVSLEEQEKMDLKTSRELCSRLDASISNNSTSKRKSESATCNLVRDIN
KVGIGLVAAASSPLLVKDVICEDDKGKIMEEVMRTYLKQQEKLNLILQKKQQLQMEVKMLSSSKSMKELTEEQQNLQKELESLQNEHAQR
MEEFYVEQKDLEKKLEQIMKQKCTCDSNLEKDKEAEYAGQLAELRQRLDHAEADRQELQDELRQEREARQKLEMMIKELKLQILKSSKTA

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SSBP1-SKIL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SSBP1-SKIL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SSBP1-SKIL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource