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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SSBP3-TBC1D1 (FusionGDB2 ID:86733)

Fusion Gene Summary for SSBP3-TBC1D1

check button Fusion gene summary
Fusion gene informationFusion gene name: SSBP3-TBC1D1
Fusion gene ID: 86733
HgeneTgene
Gene symbol

SSBP3

TBC1D1

Gene ID

23648

23216

Gene namesingle stranded DNA binding protein 3TBC1 domain family member 1
SynonymsCSDP|SSDP|SSDP1TBC|TBC1
Cytomap

1p32.3

4p14

Type of geneprotein-codingprotein-coding
Descriptionsingle-stranded DNA-binding protein 3sequence-specific single-stranded-DNA-binding proteinTBC1 domain family member 1TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000357475, ENST00000371319, 
ENST00000371320, ENST00000417664, 
ENST00000326956, 		ENST00000407365, 
ENST00000402522, ENST00000261439, 
ENST00000508802, 
Fusion gene scores* DoF score13 X 9 X 6=70214 X 11 X 6=924
# samples 1415
** MAII scorelog2(14/702*10)=-2.32604420335959
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/924*10)=-2.62293035092018
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SSBP3 [Title/Abstract] AND TBC1D1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSSBP3(54867533)-TBC1D1(38134704), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SSBP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TBC1D1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PAADTCGA-FB-AAPUSSBP3chr1

54867533

-TBC1D1chr4

38134704

+


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Fusion Gene ORF analysis for SSBP3-TBC1D1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000357475ENST00000407365SSBP3chr1

54867533

-TBC1D1chr4

38134704

+
5CDS-3UTRENST00000371319ENST00000407365SSBP3chr1

54867533

-TBC1D1chr4

38134704

+
5CDS-3UTRENST00000371320ENST00000407365SSBP3chr1

54867533

-TBC1D1chr4

38134704

+
5CDS-intronENST00000357475ENST00000402522SSBP3chr1

54867533

-TBC1D1chr4

38134704

+
5CDS-intronENST00000371319ENST00000402522SSBP3chr1

54867533

-TBC1D1chr4

38134704

+
5CDS-intronENST00000371320ENST00000402522SSBP3chr1

54867533

-TBC1D1chr4

38134704

+
5UTR-3CDSENST00000417664ENST00000261439SSBP3chr1

54867533

-TBC1D1chr4

38134704

+
5UTR-3CDSENST00000417664ENST00000508802SSBP3chr1

54867533

-TBC1D1chr4

38134704

+
5UTR-3UTRENST00000417664ENST00000407365SSBP3chr1

54867533

-TBC1D1chr4

38134704

+
5UTR-intronENST00000417664ENST00000402522SSBP3chr1

54867533

-TBC1D1chr4

38134704

+
In-frameENST00000357475ENST00000261439SSBP3chr1

54867533

-TBC1D1chr4

38134704

+
In-frameENST00000357475ENST00000508802SSBP3chr1

54867533

-TBC1D1chr4

38134704

+
In-frameENST00000371319ENST00000261439SSBP3chr1

54867533

-TBC1D1chr4

38134704

+
In-frameENST00000371319ENST00000508802SSBP3chr1

54867533

-TBC1D1chr4

38134704

+
In-frameENST00000371320ENST00000261439SSBP3chr1

54867533

-TBC1D1chr4

38134704

+
In-frameENST00000371320ENST00000508802SSBP3chr1

54867533

-TBC1D1chr4

38134704

+
intron-3CDSENST00000326956ENST00000261439SSBP3chr1

54867533

-TBC1D1chr4

38134704

+
intron-3CDSENST00000326956ENST00000508802SSBP3chr1

54867533

-TBC1D1chr4

38134704

+
intron-3UTRENST00000326956ENST00000407365SSBP3chr1

54867533

-TBC1D1chr4

38134704

+
intron-intronENST00000326956ENST00000402522SSBP3chr1

54867533

-TBC1D1chr4

38134704

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000371320SSBP3chr154867533-ENST00000508802TBC1D1chr438134704+13466874021061219
ENST00000371320SSBP3chr154867533-ENST00000261439TBC1D1chr438134704+29006874021061219
ENST00000371319SSBP3chr154867533-ENST00000508802TBC1D1chr438134704+9352760650216
ENST00000371319SSBP3chr154867533-ENST00000261439TBC1D1chr438134704+24892760650216
ENST00000357475SSBP3chr154867533-ENST00000508802TBC1D1chr438134704+1150491206865219
ENST00000357475SSBP3chr154867533-ENST00000261439TBC1D1chr438134704+2704491206865219

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000371320ENST00000508802SSBP3chr154867533-TBC1D1chr438134704+0.0053399960.99465996
ENST00000371320ENST00000261439SSBP3chr154867533-TBC1D1chr438134704+0.0014403250.99855965
ENST00000371319ENST00000508802SSBP3chr154867533-TBC1D1chr438134704+0.0037254840.9962746
ENST00000371319ENST00000261439SSBP3chr154867533-TBC1D1chr438134704+0.0014507590.99854916
ENST00000357475ENST00000508802SSBP3chr154867533-TBC1D1chr438134704+0.0066371690.9933628
ENST00000357475ENST00000261439SSBP3chr154867533-TBC1D1chr438134704+0.0017013580.9982987

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Fusion Genomic Features for SSBP3-TBC1D1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SSBP3chr154867533-TBC1D1chr438134704+0.0008502670.9991497
SSBP3chr154867533-TBC1D1chr438134704+0.0008502670.9991497

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SSBP3-TBC1D1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:54867533/chr4:38134704)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSSBP3chr1:54867533chr4:38134704ENST00000357475-41716_4892369.0DomainLisH
HgeneSSBP3chr1:54867533chr4:38134704ENST00000371319-41716_4892362.0DomainLisH
HgeneSSBP3chr1:54867533chr4:38134704ENST00000371320-41816_4892389.0DomainLisH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSSBP3chr1:54867533chr4:38134704ENST00000357475-417158_36992369.0Compositional biasNote=Gly-rich
HgeneSSBP3chr1:54867533chr4:38134704ENST00000357475-41798_31992369.0Compositional biasNote=Pro-rich
HgeneSSBP3chr1:54867533chr4:38134704ENST00000371319-417158_36992362.0Compositional biasNote=Gly-rich
HgeneSSBP3chr1:54867533chr4:38134704ENST00000371319-41798_31992362.0Compositional biasNote=Pro-rich
HgeneSSBP3chr1:54867533chr4:38134704ENST00000371320-418158_36992389.0Compositional biasNote=Gly-rich
HgeneSSBP3chr1:54867533chr4:38134704ENST00000371320-41898_31992389.0Compositional biasNote=Pro-rich
TgeneTBC1D1chr1:54867533chr4:38134704ENST000002614391720246_40410441169.0DomainPID
TgeneTBC1D1chr1:54867533chr4:38134704ENST000002614391720800_99410441169.0DomainRab-GAP TBC
TgeneTBC1D1chr1:54867533chr4:38134704ENST000005088021821246_40410351160.0DomainPID
TgeneTBC1D1chr1:54867533chr4:38134704ENST000005088021821800_99410351160.0DomainRab-GAP TBC


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Fusion Gene Sequence for SSBP3-TBC1D1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>86733_86733_1_SSBP3-TBC1D1_SSBP3_chr1_54867533_ENST00000357475_TBC1D1_chr4_38134704_ENST00000261439_length(transcript)=2704nt_BP=491nt
CCGCGGCCGGGGCTGACGCTTTGACAGCTGGAAAGAGCGCGGAGCCAGCGCCTGGGGGGGAGGGAGGGGAGCGCGGCGAGGAGAGCGCCA
GCGAGCGAGAGAGCGAGCGAGCGCCGGGGAGGGGGCCGGGAGCGAGGGGCAGCTCGGGAGAGCCGGAGCGGTAGCGGCGGCGGCGGCGGC
GGCGGCGAGGCTCGGCGCCCTCTTCCCTGCAAACCATGTTTGCCAAAGGCAAAGGCTCGGCGGTGCCCTCGGATGGGCAGGCTCGGGAAA
AGTTAGCTTTATACGTCTACGAATATTTACTGCACGTAGGAGCACAGAAATCTGCACAGACCTTCTTATCGGAGATTCGATGGGAAAAAA
ACATCACGTTGGGAGAACCGCCTGGGTTTTTGCACTCGTGGTGGTGTGTATTTTGGGACCTTTACTGTGCAGCTCCTGAAAGGAGAGACA
CTTGTGAACATTCAAGTGAAGCAAAAGCCTTTCATGATTATGTATTTGAAATGGACATCGCTAAACAGTTACAAGCTTATGAAGTTGAGT
ACCACGTCCTTCAAGAAGAACTTATCGATTCCTCTCCTCTCAGTGACAACCAAAGAATGGATAAATTAGAGAAAACCAACAGCAGCTTAC
GCAAACAGAACCTTGACCTCCTTGAACAGTTGCAGGTGGCAAATGGTAGGATCCAAAGCCTTGAGGCCACCATTGAGAAGCTCCTGAGCA
GTGAGAGCAAGCTGAAGCAGGCCATGCTTACCTTAGAACTGGAGCGGTCGGCCCTGCTGCAGACGGTGGAGGAGCTGCGGCGGCGGAGCG
CAGAGCCCAGCGACCGGGAGCCTGAGTGCACGCAGCCCGAGCCCACGGGCGACTGACAGCTCTGCAGGAGAGATTGCAACACCATCCCAC
ACTGTCCAGGCCTTAACTGAGAGGGACAGAAGACGCTGGAAGGAGAGAAGGAAGCGGGAAGTGTGCTTCTCAGGGAGGAAACCGGCTTGC
CAGCAAGTAGATTCTTACGAACTCCAACTTGCAATTCAGGGGGCATGTCCCAGTGTTTTTTTTGTTGTTTTTAGATACTAAATCGTCCCT
TCTCCAGTCCTGATTACTGTACACAGTAGCTTTAGATGGCGTGGACGTGAATAAATGCAACTTATGTTTTCTTGTTGGTTCCTTTTTGAG
TGTCACTGTGTTTGTAAAGAGCATTCACAATACGGTGGAATTTCAAAAGCTGGAAGAGCTCGAGATCATGCCTCAGGCAAAGGCGTGGGT
CCATCGTTCTTCCGAGAGGGTTTGTGTGGCGACTACACCCTCAGCGTCCCTGGCAAGGTGCAGTTGGCTCTCGCCCATTCTTGTTATGGA
AACCTAAGATGATCATTGGGAAGATCAGTGATCTTGGGTCATTGATCCCTGGCTCAGAGGATAGCGGTTTCCATCATAAACCAAGATGAT
GAGTTCAGCCTTTATCCCTCGTGGTTCCACTAGATGTAACTTAAAGGAGTTAACATTTGAGGACTTTGTTCTACATCAGATTTTACTATT
TGAATGTTTAAGATCACTTTATTGAATTTGAAGATCATCAAATTAAATAAAATGATTTATTTAATTTGGATATCCTGATCACTGTCAAGT
GAAATGGATCTCTCTCTTTGGTATTTAAGGAAGTTTGTCTTTAAAAAAAAAATAGAGTGTTTTCATACATTTTTGCTTATCCCATAAGTA
CAGTTGATCAAAGTCATAGTAGGTAAATGCTTTATGGGACAGCTGACACCTTTTAGACCCTACCAGGTATTGCTAGCATGTGAGCTGCAG
TTGTGGGGTCTGAGATATTTCTTTGTGGTAGTTTCATACCCATACTATAGAGTCATGTATTTATTTTTGCCTGTTGTGTGATGTAATGCA
ATCATGTTCCTTTGAGTCTCCATCCCTTGGAAATCTGACTTCTTGCAGAAGGAGTAGGCACATCAAGATATTCAGGGGTGCCCCAAGAGT
CTGGGACTTTCAAAAAAAAAAGATCAGGCTGAAACTGCAGTCAGATTTATGACAGCTGACAGTTTTTCAGAGGTCGCACACAGTGACTCT
CCTCTCTCAGGATGACGAGGACCTGTGCCTTCAACAAGCAAAATGCTGCTCACGGTTGTCCTGCTTGCAGCCAGTCACTGTGTAAAGCCT
CTCTGATGTGCACTTAAGAGTGGGTTGCTTTCTCACAAAGATGGGGTTCTGTGCAGTCACAGGTCACTTCCTTGACAACACAATCATTTC
TGATCTTTATCACTGTAACCACGTCTTCTATTCCATAGGAGTTTCTTTTGATTCTCTCAGTTGCGGGGGGCATCTCTTAATCCTGGGGTA
AAAGGAGAGATTGCCATACTTAGACTCACTGTGAGTCTCCCCGGCCATTTCACGAGGAGACCACAGTGCTGCCACCAGTGCCTAAACAGG
TGGCTGGCATTCGAGACTTCCTCCTGTTCCCTGGGTCAGAGGATAGCGGTTTCCATCATAAACCAAGATGATGAGTTCAGCCTTTATCCC
TCGTGGTTCCGCTAGATGTAACTTATAGGAGTTAACATTTGAGGACTTTGTTCTGCATCAGATCTTACTATTTGAATGTTTACTGTTGGA
TTTTGGGCATCTTATTACTGTTACTCAAAAACATTGACTCTGCATCAAGAAAGAAACAAGAAAGCAATAAAACAAGAAATAATTCATGCT

>86733_86733_1_SSBP3-TBC1D1_SSBP3_chr1_54867533_ENST00000357475_TBC1D1_chr4_38134704_ENST00000261439_length(amino acids)=219AA_BP=95
MQTMFAKGKGSAVPSDGQAREKLALYVYEYLLHVGAQKSAQTFLSEIRWEKNITLGEPPGFLHSWWCVFWDLYCAAPERRDTCEHSSEAK
AFHDYVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAM

--------------------------------------------------------------
>86733_86733_2_SSBP3-TBC1D1_SSBP3_chr1_54867533_ENST00000357475_TBC1D1_chr4_38134704_ENST00000508802_length(transcript)=1150nt_BP=491nt
CCGCGGCCGGGGCTGACGCTTTGACAGCTGGAAAGAGCGCGGAGCCAGCGCCTGGGGGGGAGGGAGGGGAGCGCGGCGAGGAGAGCGCCA
GCGAGCGAGAGAGCGAGCGAGCGCCGGGGAGGGGGCCGGGAGCGAGGGGCAGCTCGGGAGAGCCGGAGCGGTAGCGGCGGCGGCGGCGGC
GGCGGCGAGGCTCGGCGCCCTCTTCCCTGCAAACCATGTTTGCCAAAGGCAAAGGCTCGGCGGTGCCCTCGGATGGGCAGGCTCGGGAAA
AGTTAGCTTTATACGTCTACGAATATTTACTGCACGTAGGAGCACAGAAATCTGCACAGACCTTCTTATCGGAGATTCGATGGGAAAAAA
ACATCACGTTGGGAGAACCGCCTGGGTTTTTGCACTCGTGGTGGTGTGTATTTTGGGACCTTTACTGTGCAGCTCCTGAAAGGAGAGACA
CTTGTGAACATTCAAGTGAAGCAAAAGCCTTTCATGATTATGTATTTGAAATGGACATCGCTAAACAGTTACAAGCTTATGAAGTTGAGT
ACCACGTCCTTCAAGAAGAACTTATCGATTCCTCTCCTCTCAGTGACAACCAAAGAATGGATAAATTAGAGAAAACCAACAGCAGCTTAC
GCAAACAGAACCTTGACCTCCTTGAACAGTTGCAGGTGGCAAATGGTAGGATCCAAAGCCTTGAGGCCACCATTGAGAAGCTCCTGAGCA
GTGAGAGCAAGCTGAAGCAGGCCATGCTTACCTTAGAACTGGAGCGGTCGGCCCTGCTGCAGACGGTGGAGGAGCTGCGGCGGCGGAGCG
CAGAGCCCAGCGACCGGGAGCCTGAGTGCACGCAGCCCGAGCCCACGGGCGACTGACAGCTCTGCAGGAGAGATTGCAACACCATCCCAC
ACTGTCCAGGCCTTAACTGAGAGGGACAGAAGACGCTGGAAGGAGAGAAGGAAGCGGGAAGTGTGCTTCTCAGGGAGGAAACCGGCTTGC
CAGCAAGTAGATTCTTACGAACTCCAACTTGCAATTCAGGGGGCATGTCCCAGTGTTTTTTTTGTTGTTTTTAGATACTAAATCGTCCCT

>86733_86733_2_SSBP3-TBC1D1_SSBP3_chr1_54867533_ENST00000357475_TBC1D1_chr4_38134704_ENST00000508802_length(amino acids)=219AA_BP=95
MQTMFAKGKGSAVPSDGQAREKLALYVYEYLLHVGAQKSAQTFLSEIRWEKNITLGEPPGFLHSWWCVFWDLYCAAPERRDTCEHSSEAK
AFHDYVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAM

--------------------------------------------------------------
>86733_86733_3_SSBP3-TBC1D1_SSBP3_chr1_54867533_ENST00000371319_TBC1D1_chr4_38134704_ENST00000261439_length(transcript)=2489nt_BP=276nt
ATGTTTGCCAAAGGCAAAGGCTCGGCGGTGCCCTCGGATGGGCAGGCTCGGGAAAAGTTAGCTTTATACGTCTACGAATATTTACTGCAC
GTAGGAGCACAGAAATCTGCACAGACCTTCTTATCGGAGATTCGATGGGAAAAAAACATCACGTTGGGAGAACCGCCTGGGTTTTTGCAC
TCGTGGTGGTGTGTATTTTGGGACCTTTACTGTGCAGCTCCTGAAAGGAGAGACACTTGTGAACATTCAAGTGAAGCAAAAGCCTTTCAT
GATTATGTATTTGAAATGGACATCGCTAAACAGTTACAAGCTTATGAAGTTGAGTACCACGTCCTTCAAGAAGAACTTATCGATTCCTCT
CCTCTCAGTGACAACCAAAGAATGGATAAATTAGAGAAAACCAACAGCAGCTTACGCAAACAGAACCTTGACCTCCTTGAACAGTTGCAG
GTGGCAAATGGTAGGATCCAAAGCCTTGAGGCCACCATTGAGAAGCTCCTGAGCAGTGAGAGCAAGCTGAAGCAGGCCATGCTTACCTTA
GAACTGGAGCGGTCGGCCCTGCTGCAGACGGTGGAGGAGCTGCGGCGGCGGAGCGCAGAGCCCAGCGACCGGGAGCCTGAGTGCACGCAG
CCCGAGCCCACGGGCGACTGACAGCTCTGCAGGAGAGATTGCAACACCATCCCACACTGTCCAGGCCTTAACTGAGAGGGACAGAAGACG
CTGGAAGGAGAGAAGGAAGCGGGAAGTGTGCTTCTCAGGGAGGAAACCGGCTTGCCAGCAAGTAGATTCTTACGAACTCCAACTTGCAAT
TCAGGGGGCATGTCCCAGTGTTTTTTTTGTTGTTTTTAGATACTAAATCGTCCCTTCTCCAGTCCTGATTACTGTACACAGTAGCTTTAG
ATGGCGTGGACGTGAATAAATGCAACTTATGTTTTCTTGTTGGTTCCTTTTTGAGTGTCACTGTGTTTGTAAAGAGCATTCACAATACGG
TGGAATTTCAAAAGCTGGAAGAGCTCGAGATCATGCCTCAGGCAAAGGCGTGGGTCCATCGTTCTTCCGAGAGGGTTTGTGTGGCGACTA
CACCCTCAGCGTCCCTGGCAAGGTGCAGTTGGCTCTCGCCCATTCTTGTTATGGAAACCTAAGATGATCATTGGGAAGATCAGTGATCTT
GGGTCATTGATCCCTGGCTCAGAGGATAGCGGTTTCCATCATAAACCAAGATGATGAGTTCAGCCTTTATCCCTCGTGGTTCCACTAGAT
GTAACTTAAAGGAGTTAACATTTGAGGACTTTGTTCTACATCAGATTTTACTATTTGAATGTTTAAGATCACTTTATTGAATTTGAAGAT
CATCAAATTAAATAAAATGATTTATTTAATTTGGATATCCTGATCACTGTCAAGTGAAATGGATCTCTCTCTTTGGTATTTAAGGAAGTT
TGTCTTTAAAAAAAAAATAGAGTGTTTTCATACATTTTTGCTTATCCCATAAGTACAGTTGATCAAAGTCATAGTAGGTAAATGCTTTAT
GGGACAGCTGACACCTTTTAGACCCTACCAGGTATTGCTAGCATGTGAGCTGCAGTTGTGGGGTCTGAGATATTTCTTTGTGGTAGTTTC
ATACCCATACTATAGAGTCATGTATTTATTTTTGCCTGTTGTGTGATGTAATGCAATCATGTTCCTTTGAGTCTCCATCCCTTGGAAATC
TGACTTCTTGCAGAAGGAGTAGGCACATCAAGATATTCAGGGGTGCCCCAAGAGTCTGGGACTTTCAAAAAAAAAAGATCAGGCTGAAAC
TGCAGTCAGATTTATGACAGCTGACAGTTTTTCAGAGGTCGCACACAGTGACTCTCCTCTCTCAGGATGACGAGGACCTGTGCCTTCAAC
AAGCAAAATGCTGCTCACGGTTGTCCTGCTTGCAGCCAGTCACTGTGTAAAGCCTCTCTGATGTGCACTTAAGAGTGGGTTGCTTTCTCA
CAAAGATGGGGTTCTGTGCAGTCACAGGTCACTTCCTTGACAACACAATCATTTCTGATCTTTATCACTGTAACCACGTCTTCTATTCCA
TAGGAGTTTCTTTTGATTCTCTCAGTTGCGGGGGGCATCTCTTAATCCTGGGGTAAAAGGAGAGATTGCCATACTTAGACTCACTGTGAG
TCTCCCCGGCCATTTCACGAGGAGACCACAGTGCTGCCACCAGTGCCTAAACAGGTGGCTGGCATTCGAGACTTCCTCCTGTTCCCTGGG
TCAGAGGATAGCGGTTTCCATCATAAACCAAGATGATGAGTTCAGCCTTTATCCCTCGTGGTTCCGCTAGATGTAACTTATAGGAGTTAA
CATTTGAGGACTTTGTTCTGCATCAGATCTTACTATTTGAATGTTTACTGTTGGATTTTGGGCATCTTATTACTGTTACTCAAAAACATT

>86733_86733_3_SSBP3-TBC1D1_SSBP3_chr1_54867533_ENST00000371319_TBC1D1_chr4_38134704_ENST00000261439_length(amino acids)=216AA_BP=92
MFAKGKGSAVPSDGQAREKLALYVYEYLLHVGAQKSAQTFLSEIRWEKNITLGEPPGFLHSWWCVFWDLYCAAPERRDTCEHSSEAKAFH
DYVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTL

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>86733_86733_4_SSBP3-TBC1D1_SSBP3_chr1_54867533_ENST00000371319_TBC1D1_chr4_38134704_ENST00000508802_length(transcript)=935nt_BP=276nt
ATGTTTGCCAAAGGCAAAGGCTCGGCGGTGCCCTCGGATGGGCAGGCTCGGGAAAAGTTAGCTTTATACGTCTACGAATATTTACTGCAC
GTAGGAGCACAGAAATCTGCACAGACCTTCTTATCGGAGATTCGATGGGAAAAAAACATCACGTTGGGAGAACCGCCTGGGTTTTTGCAC
TCGTGGTGGTGTGTATTTTGGGACCTTTACTGTGCAGCTCCTGAAAGGAGAGACACTTGTGAACATTCAAGTGAAGCAAAAGCCTTTCAT
GATTATGTATTTGAAATGGACATCGCTAAACAGTTACAAGCTTATGAAGTTGAGTACCACGTCCTTCAAGAAGAACTTATCGATTCCTCT
CCTCTCAGTGACAACCAAAGAATGGATAAATTAGAGAAAACCAACAGCAGCTTACGCAAACAGAACCTTGACCTCCTTGAACAGTTGCAG
GTGGCAAATGGTAGGATCCAAAGCCTTGAGGCCACCATTGAGAAGCTCCTGAGCAGTGAGAGCAAGCTGAAGCAGGCCATGCTTACCTTA
GAACTGGAGCGGTCGGCCCTGCTGCAGACGGTGGAGGAGCTGCGGCGGCGGAGCGCAGAGCCCAGCGACCGGGAGCCTGAGTGCACGCAG
CCCGAGCCCACGGGCGACTGACAGCTCTGCAGGAGAGATTGCAACACCATCCCACACTGTCCAGGCCTTAACTGAGAGGGACAGAAGACG
CTGGAAGGAGAGAAGGAAGCGGGAAGTGTGCTTCTCAGGGAGGAAACCGGCTTGCCAGCAAGTAGATTCTTACGAACTCCAACTTGCAAT
TCAGGGGGCATGTCCCAGTGTTTTTTTTGTTGTTTTTAGATACTAAATCGTCCCTTCTCCAGTCCTGATTACTGTACACAGTAGCTTTAG

>86733_86733_4_SSBP3-TBC1D1_SSBP3_chr1_54867533_ENST00000371319_TBC1D1_chr4_38134704_ENST00000508802_length(amino acids)=216AA_BP=92
MFAKGKGSAVPSDGQAREKLALYVYEYLLHVGAQKSAQTFLSEIRWEKNITLGEPPGFLHSWWCVFWDLYCAAPERRDTCEHSSEAKAFH
DYVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTL

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>86733_86733_5_SSBP3-TBC1D1_SSBP3_chr1_54867533_ENST00000371320_TBC1D1_chr4_38134704_ENST00000261439_length(transcript)=2900nt_BP=687nt
AGCCACGTTCGGTTGAGCTCCAAGTAGACCAGCGGCGGCGGCGGCGGCGGCGGCGGCAGCGGTGCTGGAGGCGCAGAGGGCGGCGCAGGC
GGAGCCGGGCGGGCGCGCGAGCGAGCGGAGAGCGGGCGGCCGTGCGGGCGGCGGCGGCGGCACCCCCAGGCCGAGCCGGCGCGGAAGGAG
TTCCAGGGCGATGGGGCCGCGGCCGGGGCTGACGCTTTGACAGCTGGAAAGAGCGCGGAGCCAGCGCCTGGGGGGGAGGGAGGGGAGCGC
GGCGAGGAGAGCGCCAGCGAGCGAGAGAGCGAGCGAGCGCCGGGGAGGGGGCCGGGAGCGAGGGGCAGCTCGGGAGAGCCGGAGCGGTAG
CGGCGGCGGCGGCGGCGGCGGCGAGGCTCGGCGCCCTCTTCCCTGCAAACCATGTTTGCCAAAGGCAAAGGCTCGGCGGTGCCCTCGGAT
GGGCAGGCTCGGGAAAAGTTAGCTTTATACGTCTACGAATATTTACTGCACGTAGGAGCACAGAAATCTGCACAGACCTTCTTATCGGAG
ATTCGATGGGAAAAAAACATCACGTTGGGAGAACCGCCTGGGTTTTTGCACTCGTGGTGGTGTGTATTTTGGGACCTTTACTGTGCAGCT
CCTGAAAGGAGAGACACTTGTGAACATTCAAGTGAAGCAAAAGCCTTTCATGATTATGTATTTGAAATGGACATCGCTAAACAGTTACAA
GCTTATGAAGTTGAGTACCACGTCCTTCAAGAAGAACTTATCGATTCCTCTCCTCTCAGTGACAACCAAAGAATGGATAAATTAGAGAAA
ACCAACAGCAGCTTACGCAAACAGAACCTTGACCTCCTTGAACAGTTGCAGGTGGCAAATGGTAGGATCCAAAGCCTTGAGGCCACCATT
GAGAAGCTCCTGAGCAGTGAGAGCAAGCTGAAGCAGGCCATGCTTACCTTAGAACTGGAGCGGTCGGCCCTGCTGCAGACGGTGGAGGAG
CTGCGGCGGCGGAGCGCAGAGCCCAGCGACCGGGAGCCTGAGTGCACGCAGCCCGAGCCCACGGGCGACTGACAGCTCTGCAGGAGAGAT
TGCAACACCATCCCACACTGTCCAGGCCTTAACTGAGAGGGACAGAAGACGCTGGAAGGAGAGAAGGAAGCGGGAAGTGTGCTTCTCAGG
GAGGAAACCGGCTTGCCAGCAAGTAGATTCTTACGAACTCCAACTTGCAATTCAGGGGGCATGTCCCAGTGTTTTTTTTGTTGTTTTTAG
ATACTAAATCGTCCCTTCTCCAGTCCTGATTACTGTACACAGTAGCTTTAGATGGCGTGGACGTGAATAAATGCAACTTATGTTTTCTTG
TTGGTTCCTTTTTGAGTGTCACTGTGTTTGTAAAGAGCATTCACAATACGGTGGAATTTCAAAAGCTGGAAGAGCTCGAGATCATGCCTC
AGGCAAAGGCGTGGGTCCATCGTTCTTCCGAGAGGGTTTGTGTGGCGACTACACCCTCAGCGTCCCTGGCAAGGTGCAGTTGGCTCTCGC
CCATTCTTGTTATGGAAACCTAAGATGATCATTGGGAAGATCAGTGATCTTGGGTCATTGATCCCTGGCTCAGAGGATAGCGGTTTCCAT
CATAAACCAAGATGATGAGTTCAGCCTTTATCCCTCGTGGTTCCACTAGATGTAACTTAAAGGAGTTAACATTTGAGGACTTTGTTCTAC
ATCAGATTTTACTATTTGAATGTTTAAGATCACTTTATTGAATTTGAAGATCATCAAATTAAATAAAATGATTTATTTAATTTGGATATC
CTGATCACTGTCAAGTGAAATGGATCTCTCTCTTTGGTATTTAAGGAAGTTTGTCTTTAAAAAAAAAATAGAGTGTTTTCATACATTTTT
GCTTATCCCATAAGTACAGTTGATCAAAGTCATAGTAGGTAAATGCTTTATGGGACAGCTGACACCTTTTAGACCCTACCAGGTATTGCT
AGCATGTGAGCTGCAGTTGTGGGGTCTGAGATATTTCTTTGTGGTAGTTTCATACCCATACTATAGAGTCATGTATTTATTTTTGCCTGT
TGTGTGATGTAATGCAATCATGTTCCTTTGAGTCTCCATCCCTTGGAAATCTGACTTCTTGCAGAAGGAGTAGGCACATCAAGATATTCA
GGGGTGCCCCAAGAGTCTGGGACTTTCAAAAAAAAAAGATCAGGCTGAAACTGCAGTCAGATTTATGACAGCTGACAGTTTTTCAGAGGT
CGCACACAGTGACTCTCCTCTCTCAGGATGACGAGGACCTGTGCCTTCAACAAGCAAAATGCTGCTCACGGTTGTCCTGCTTGCAGCCAG
TCACTGTGTAAAGCCTCTCTGATGTGCACTTAAGAGTGGGTTGCTTTCTCACAAAGATGGGGTTCTGTGCAGTCACAGGTCACTTCCTTG
ACAACACAATCATTTCTGATCTTTATCACTGTAACCACGTCTTCTATTCCATAGGAGTTTCTTTTGATTCTCTCAGTTGCGGGGGGCATC
TCTTAATCCTGGGGTAAAAGGAGAGATTGCCATACTTAGACTCACTGTGAGTCTCCCCGGCCATTTCACGAGGAGACCACAGTGCTGCCA
CCAGTGCCTAAACAGGTGGCTGGCATTCGAGACTTCCTCCTGTTCCCTGGGTCAGAGGATAGCGGTTTCCATCATAAACCAAGATGATGA
GTTCAGCCTTTATCCCTCGTGGTTCCGCTAGATGTAACTTATAGGAGTTAACATTTGAGGACTTTGTTCTGCATCAGATCTTACTATTTG
AATGTTTACTGTTGGATTTTGGGCATCTTATTACTGTTACTCAAAAACATTGACTCTGCATCAAGAAAGAAACAAGAAAGCAATAAAACA

>86733_86733_5_SSBP3-TBC1D1_SSBP3_chr1_54867533_ENST00000371320_TBC1D1_chr4_38134704_ENST00000261439_length(amino acids)=219AA_BP=95
MQTMFAKGKGSAVPSDGQAREKLALYVYEYLLHVGAQKSAQTFLSEIRWEKNITLGEPPGFLHSWWCVFWDLYCAAPERRDTCEHSSEAK
AFHDYVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAM

--------------------------------------------------------------
>86733_86733_6_SSBP3-TBC1D1_SSBP3_chr1_54867533_ENST00000371320_TBC1D1_chr4_38134704_ENST00000508802_length(transcript)=1346nt_BP=687nt
AGCCACGTTCGGTTGAGCTCCAAGTAGACCAGCGGCGGCGGCGGCGGCGGCGGCGGCAGCGGTGCTGGAGGCGCAGAGGGCGGCGCAGGC
GGAGCCGGGCGGGCGCGCGAGCGAGCGGAGAGCGGGCGGCCGTGCGGGCGGCGGCGGCGGCACCCCCAGGCCGAGCCGGCGCGGAAGGAG
TTCCAGGGCGATGGGGCCGCGGCCGGGGCTGACGCTTTGACAGCTGGAAAGAGCGCGGAGCCAGCGCCTGGGGGGGAGGGAGGGGAGCGC
GGCGAGGAGAGCGCCAGCGAGCGAGAGAGCGAGCGAGCGCCGGGGAGGGGGCCGGGAGCGAGGGGCAGCTCGGGAGAGCCGGAGCGGTAG
CGGCGGCGGCGGCGGCGGCGGCGAGGCTCGGCGCCCTCTTCCCTGCAAACCATGTTTGCCAAAGGCAAAGGCTCGGCGGTGCCCTCGGAT
GGGCAGGCTCGGGAAAAGTTAGCTTTATACGTCTACGAATATTTACTGCACGTAGGAGCACAGAAATCTGCACAGACCTTCTTATCGGAG
ATTCGATGGGAAAAAAACATCACGTTGGGAGAACCGCCTGGGTTTTTGCACTCGTGGTGGTGTGTATTTTGGGACCTTTACTGTGCAGCT
CCTGAAAGGAGAGACACTTGTGAACATTCAAGTGAAGCAAAAGCCTTTCATGATTATGTATTTGAAATGGACATCGCTAAACAGTTACAA
GCTTATGAAGTTGAGTACCACGTCCTTCAAGAAGAACTTATCGATTCCTCTCCTCTCAGTGACAACCAAAGAATGGATAAATTAGAGAAA
ACCAACAGCAGCTTACGCAAACAGAACCTTGACCTCCTTGAACAGTTGCAGGTGGCAAATGGTAGGATCCAAAGCCTTGAGGCCACCATT
GAGAAGCTCCTGAGCAGTGAGAGCAAGCTGAAGCAGGCCATGCTTACCTTAGAACTGGAGCGGTCGGCCCTGCTGCAGACGGTGGAGGAG
CTGCGGCGGCGGAGCGCAGAGCCCAGCGACCGGGAGCCTGAGTGCACGCAGCCCGAGCCCACGGGCGACTGACAGCTCTGCAGGAGAGAT
TGCAACACCATCCCACACTGTCCAGGCCTTAACTGAGAGGGACAGAAGACGCTGGAAGGAGAGAAGGAAGCGGGAAGTGTGCTTCTCAGG
GAGGAAACCGGCTTGCCAGCAAGTAGATTCTTACGAACTCCAACTTGCAATTCAGGGGGCATGTCCCAGTGTTTTTTTTGTTGTTTTTAG

>86733_86733_6_SSBP3-TBC1D1_SSBP3_chr1_54867533_ENST00000371320_TBC1D1_chr4_38134704_ENST00000508802_length(amino acids)=219AA_BP=95
MQTMFAKGKGSAVPSDGQAREKLALYVYEYLLHVGAQKSAQTFLSEIRWEKNITLGEPPGFLHSWWCVFWDLYCAAPERRDTCEHSSEAK
AFHDYVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAM

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Fusion Gene PPI Analysis for SSBP3-TBC1D1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SSBP3-TBC1D1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SSBP3-TBC1D1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource