FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:SSBP4-EIF4ENIF1 (FusionGDB2 ID:86735)

Fusion Gene Summary for SSBP4-EIF4ENIF1

check button Fusion gene summary
Fusion gene informationFusion gene name: SSBP4-EIF4ENIF1
Fusion gene ID: 86735
HgeneTgene
Gene symbol

SSBP4

EIF4ENIF1

Gene ID

170463

56478

Gene namesingle stranded DNA binding protein 4eukaryotic translation initiation factor 4E nuclear import factor 1
Synonyms-4E-T|Clast4
Cytomap

19p13.11

22q12.2

Type of geneprotein-codingprotein-coding
Descriptionsingle-stranded DNA-binding protein 4eukaryotic translation initiation factor 4E transporter2610509L04Rik4E-transportereIF4E transporter
Modification date2020031320200327
UniProtAcc.

Q9NRA8

Ensembl transtripts involved in fusion geneENST00000270061, ENST00000348495, 
ENST00000599699, ENST00000598159, 
ENST00000330125, ENST00000344710, 
ENST00000382180, ENST00000397523, 
ENST00000397525, ENST00000441289, 
Fusion gene scores* DoF score5 X 4 X 4=8010 X 7 X 9=630
# samples 511
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/630*10)=-2.51784830486262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SSBP4 [Title/Abstract] AND EIF4ENIF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSSBP4(18545232)-EIF4ENIF1(31851654), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SSBP4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across EIF4ENIF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACB049711SSBP4chr19

18545232

+EIF4ENIF1chr22

31851654

-


Top

Fusion Gene ORF analysis for SSBP4-EIF4ENIF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000270061ENST00000330125SSBP4chr19

18545232

+EIF4ENIF1chr22

31851654

-
3UTR-intronENST00000270061ENST00000344710SSBP4chr19

18545232

+EIF4ENIF1chr22

31851654

-
3UTR-intronENST00000270061ENST00000382180SSBP4chr19

18545232

+EIF4ENIF1chr22

31851654

-
3UTR-intronENST00000270061ENST00000397523SSBP4chr19

18545232

+EIF4ENIF1chr22

31851654

-
3UTR-intronENST00000270061ENST00000397525SSBP4chr19

18545232

+EIF4ENIF1chr22

31851654

-
3UTR-intronENST00000270061ENST00000441289SSBP4chr19

18545232

+EIF4ENIF1chr22

31851654

-
3UTR-intronENST00000348495ENST00000330125SSBP4chr19

18545232

+EIF4ENIF1chr22

31851654

-
3UTR-intronENST00000348495ENST00000344710SSBP4chr19

18545232

+EIF4ENIF1chr22

31851654

-
3UTR-intronENST00000348495ENST00000382180SSBP4chr19

18545232

+EIF4ENIF1chr22

31851654

-
3UTR-intronENST00000348495ENST00000397523SSBP4chr19

18545232

+EIF4ENIF1chr22

31851654

-
3UTR-intronENST00000348495ENST00000397525SSBP4chr19

18545232

+EIF4ENIF1chr22

31851654

-
3UTR-intronENST00000348495ENST00000441289SSBP4chr19

18545232

+EIF4ENIF1chr22

31851654

-
3UTR-intronENST00000599699ENST00000330125SSBP4chr19

18545232

+EIF4ENIF1chr22

31851654

-
3UTR-intronENST00000599699ENST00000344710SSBP4chr19

18545232

+EIF4ENIF1chr22

31851654

-
3UTR-intronENST00000599699ENST00000382180SSBP4chr19

18545232

+EIF4ENIF1chr22

31851654

-
3UTR-intronENST00000599699ENST00000397523SSBP4chr19

18545232

+EIF4ENIF1chr22

31851654

-
3UTR-intronENST00000599699ENST00000397525SSBP4chr19

18545232

+EIF4ENIF1chr22

31851654

-
3UTR-intronENST00000599699ENST00000441289SSBP4chr19

18545232

+EIF4ENIF1chr22

31851654

-
intron-intronENST00000598159ENST00000330125SSBP4chr19

18545232

+EIF4ENIF1chr22

31851654

-
intron-intronENST00000598159ENST00000344710SSBP4chr19

18545232

+EIF4ENIF1chr22

31851654

-
intron-intronENST00000598159ENST00000382180SSBP4chr19

18545232

+EIF4ENIF1chr22

31851654

-
intron-intronENST00000598159ENST00000397523SSBP4chr19

18545232

+EIF4ENIF1chr22

31851654

-
intron-intronENST00000598159ENST00000397525SSBP4chr19

18545232

+EIF4ENIF1chr22

31851654

-
intron-intronENST00000598159ENST00000441289SSBP4chr19

18545232

+EIF4ENIF1chr22

31851654

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for SSBP4-EIF4ENIF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for SSBP4-EIF4ENIF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:18545232/:31851654)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EIF4ENIF1

Q9NRA8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: EIF4E-binding protein that regulates translation and stability of mRNAs in processing bodies (P-bodies) (PubMed:16157702, PubMed:24335285, PubMed:27342281, PubMed:32354837). Plays a key role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation (PubMed:24335285, PubMed:32354837). Acts as a binding platform for multiple RNA-binding proteins: promotes deadenylation of mRNAs via its interaction with the CCR4-NOT complex, and blocks decapping via interaction with eIF4E (EIF4E and EIF4E2), thereby protecting deadenylated and repressed mRNAs from degradation (PubMed:27342281, PubMed:32354837). Component of a multiprotein complex that sequesters and represses translation of proneurogenic factors during neurogenesis (By similarity). Promotes miRNA-mediated translational repression (PubMed:24335285, PubMed:27342281, PubMed:28487484). Required for the formation of P-bodies (PubMed:16157702, PubMed:22966201, PubMed:27342281, PubMed:32354837). Involved in mRNA translational repression mediated by the miRNA effector TNRC6B by protecting TNRC6B-targeted mRNAs from decapping and subsequent decay (PubMed:32354837). Also acts as a nucleoplasmic shuttling protein, which mediates the nuclear import of EIF4E and DDX6 by a piggy-back mechanism (PubMed:10856257, PubMed:28216671). {ECO:0000250|UniProtKB:Q9EST3, ECO:0000269|PubMed:10856257, ECO:0000269|PubMed:16157702, ECO:0000269|PubMed:22966201, ECO:0000269|PubMed:24335285, ECO:0000269|PubMed:27342281, ECO:0000269|PubMed:28216671, ECO:0000269|PubMed:28487484, ECO:0000269|PubMed:32354837}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for SSBP4-EIF4ENIF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for SSBP4-EIF4ENIF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for SSBP4-EIF4ENIF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for SSBP4-EIF4ENIF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource