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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SSH1-CORO1C (FusionGDB2 ID:86755)

Fusion Gene Summary for SSH1-CORO1C

check button Fusion gene summary
Fusion gene informationFusion gene name: SSH1-CORO1C
Fusion gene ID: 86755
HgeneTgene
Gene symbol

SSH1

CORO1C

Gene ID

54434

23603

Gene nameslingshot protein phosphatase 1coronin 1C
SynonymsSSH1LHCRNN4
Cytomap

12q24.11

12q24.11

Type of geneprotein-codingprotein-coding
Descriptionprotein phosphatase Slingshot homolog 1SSH-like protein 1hSSH-1Lslingshot homolog 1coronin-1Ccoronin, actin binding protein, 1Ccoronin-3
Modification date2020031320200322
UniProtAcc.

Q9ULV4

Ensembl transtripts involved in fusion geneENST00000326495, ENST00000551165, 
ENST00000360239, ENST00000326470, 
ENST00000546812, 		ENST00000261401, 
ENST00000541050, ENST00000549384, 
ENST00000420959, ENST00000421578, 
ENST00000549772, 
Fusion gene scores* DoF score9 X 9 X 8=64816 X 9 X 8=1152
# samples 1317
** MAII scorelog2(13/648*10)=-2.31748218985617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(17/1152*10)=-2.76053406530461
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SSH1 [Title/Abstract] AND CORO1C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSSH1(109251204)-CORO1C(109095099), # samples:2
Anticipated loss of major functional domain due to fusion event.SSH1-CORO1C seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SSH1-CORO1C seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSSH1

GO:0032268

regulation of cellular protein metabolic process

19000834

HgeneSSH1

GO:0071318

cellular response to ATP

19000834

TgeneCORO1C

GO:0016197

endosomal transport

30220460

TgeneCORO1C

GO:0090148

membrane fission

30220460

TgeneCORO1C

GO:0097750

endosome membrane tubulation

30220460


check buttonFusion gene breakpoints across SSH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CORO1C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AC-A3HN-01ASSH1chr12

109251204

-CORO1Cchr12

109095099

-
ChimerDB4STADTCGA-BR-8372-01ASSH1chr12

109251204

-CORO1Cchr12

109095099

-
ChimerDB4STADTCGA-VQ-A928-01ASSH1chr12

109186062

-CORO1Cchr12

109055934

-


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Fusion Gene ORF analysis for SSH1-CORO1C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000326495ENST00000261401SSH1chr12

109251204

-CORO1Cchr12

109095099

-
5CDS-5UTRENST00000326495ENST00000541050SSH1chr12

109251204

-CORO1Cchr12

109095099

-
5CDS-5UTRENST00000326495ENST00000549384SSH1chr12

109251204

-CORO1Cchr12

109095099

-
5CDS-5UTRENST00000551165ENST00000261401SSH1chr12

109251204

-CORO1Cchr12

109095099

-
5CDS-5UTRENST00000551165ENST00000541050SSH1chr12

109251204

-CORO1Cchr12

109095099

-
5CDS-5UTRENST00000551165ENST00000549384SSH1chr12

109251204

-CORO1Cchr12

109095099

-
5CDS-intronENST00000326495ENST00000420959SSH1chr12

109251204

-CORO1Cchr12

109095099

-
5CDS-intronENST00000326495ENST00000420959SSH1chr12

109186062

-CORO1Cchr12

109055934

-
5CDS-intronENST00000326495ENST00000421578SSH1chr12

109251204

-CORO1Cchr12

109095099

-
5CDS-intronENST00000326495ENST00000421578SSH1chr12

109186062

-CORO1Cchr12

109055934

-
5CDS-intronENST00000326495ENST00000549384SSH1chr12

109186062

-CORO1Cchr12

109055934

-
5CDS-intronENST00000326495ENST00000549772SSH1chr12

109251204

-CORO1Cchr12

109095099

-
5CDS-intronENST00000326495ENST00000549772SSH1chr12

109186062

-CORO1Cchr12

109055934

-
5CDS-intronENST00000360239ENST00000420959SSH1chr12

109186062

-CORO1Cchr12

109055934

-
5CDS-intronENST00000360239ENST00000421578SSH1chr12

109186062

-CORO1Cchr12

109055934

-
5CDS-intronENST00000360239ENST00000549384SSH1chr12

109186062

-CORO1Cchr12

109055934

-
5CDS-intronENST00000360239ENST00000549772SSH1chr12

109186062

-CORO1Cchr12

109055934

-
5CDS-intronENST00000551165ENST00000420959SSH1chr12

109251204

-CORO1Cchr12

109095099

-
5CDS-intronENST00000551165ENST00000421578SSH1chr12

109251204

-CORO1Cchr12

109095099

-
5CDS-intronENST00000551165ENST00000549772SSH1chr12

109251204

-CORO1Cchr12

109095099

-
5UTR-5UTRENST00000360239ENST00000261401SSH1chr12

109251204

-CORO1Cchr12

109095099

-
5UTR-5UTRENST00000360239ENST00000541050SSH1chr12

109251204

-CORO1Cchr12

109095099

-
5UTR-5UTRENST00000360239ENST00000549384SSH1chr12

109251204

-CORO1Cchr12

109095099

-
5UTR-intronENST00000360239ENST00000420959SSH1chr12

109251204

-CORO1Cchr12

109095099

-
5UTR-intronENST00000360239ENST00000421578SSH1chr12

109251204

-CORO1Cchr12

109095099

-
5UTR-intronENST00000360239ENST00000549772SSH1chr12

109251204

-CORO1Cchr12

109095099

-
Frame-shiftENST00000360239ENST00000261401SSH1chr12

109186062

-CORO1Cchr12

109055934

-
Frame-shiftENST00000360239ENST00000541050SSH1chr12

109186062

-CORO1Cchr12

109055934

-
In-frameENST00000326495ENST00000261401SSH1chr12

109186062

-CORO1Cchr12

109055934

-
In-frameENST00000326495ENST00000541050SSH1chr12

109186062

-CORO1Cchr12

109055934

-
intron-3CDSENST00000326470ENST00000261401SSH1chr12

109186062

-CORO1Cchr12

109055934

-
intron-3CDSENST00000326470ENST00000541050SSH1chr12

109186062

-CORO1Cchr12

109055934

-
intron-3CDSENST00000546812ENST00000261401SSH1chr12

109186062

-CORO1Cchr12

109055934

-
intron-3CDSENST00000546812ENST00000541050SSH1chr12

109186062

-CORO1Cchr12

109055934

-
intron-3CDSENST00000551165ENST00000261401SSH1chr12

109186062

-CORO1Cchr12

109055934

-
intron-3CDSENST00000551165ENST00000541050SSH1chr12

109186062

-CORO1Cchr12

109055934

-
intron-5UTRENST00000326470ENST00000261401SSH1chr12

109251204

-CORO1Cchr12

109095099

-
intron-5UTRENST00000326470ENST00000541050SSH1chr12

109251204

-CORO1Cchr12

109095099

-
intron-5UTRENST00000326470ENST00000549384SSH1chr12

109251204

-CORO1Cchr12

109095099

-
intron-5UTRENST00000546812ENST00000261401SSH1chr12

109251204

-CORO1Cchr12

109095099

-
intron-5UTRENST00000546812ENST00000541050SSH1chr12

109251204

-CORO1Cchr12

109095099

-
intron-5UTRENST00000546812ENST00000549384SSH1chr12

109251204

-CORO1Cchr12

109095099

-
intron-intronENST00000326470ENST00000420959SSH1chr12

109251204

-CORO1Cchr12

109095099

-
intron-intronENST00000326470ENST00000420959SSH1chr12

109186062

-CORO1Cchr12

109055934

-
intron-intronENST00000326470ENST00000421578SSH1chr12

109251204

-CORO1Cchr12

109095099

-
intron-intronENST00000326470ENST00000421578SSH1chr12

109186062

-CORO1Cchr12

109055934

-
intron-intronENST00000326470ENST00000549384SSH1chr12

109186062

-CORO1Cchr12

109055934

-
intron-intronENST00000326470ENST00000549772SSH1chr12

109251204

-CORO1Cchr12

109095099

-
intron-intronENST00000326470ENST00000549772SSH1chr12

109186062

-CORO1Cchr12

109055934

-
intron-intronENST00000546812ENST00000420959SSH1chr12

109251204

-CORO1Cchr12

109095099

-
intron-intronENST00000546812ENST00000420959SSH1chr12

109186062

-CORO1Cchr12

109055934

-
intron-intronENST00000546812ENST00000421578SSH1chr12

109251204

-CORO1Cchr12

109095099

-
intron-intronENST00000546812ENST00000421578SSH1chr12

109186062

-CORO1Cchr12

109055934

-
intron-intronENST00000546812ENST00000549384SSH1chr12

109186062

-CORO1Cchr12

109055934

-
intron-intronENST00000546812ENST00000549772SSH1chr12

109251204

-CORO1Cchr12

109095099

-
intron-intronENST00000546812ENST00000549772SSH1chr12

109186062

-CORO1Cchr12

109055934

-
intron-intronENST00000551165ENST00000420959SSH1chr12

109186062

-CORO1Cchr12

109055934

-
intron-intronENST00000551165ENST00000421578SSH1chr12

109186062

-CORO1Cchr12

109055934

-
intron-intronENST00000551165ENST00000549384SSH1chr12

109186062

-CORO1Cchr12

109055934

-
intron-intronENST00000551165ENST00000549772SSH1chr12

109186062

-CORO1Cchr12

109055934

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000326495SSH1chr12109186062-ENST00000261401CORO1Cchr12109055934-53881987943093999
ENST00000326495SSH1chr12109186062-ENST00000541050CORO1Cchr12109055934-39301987943093999

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000326495ENST00000261401SSH1chr12109186062-CORO1Cchr12109055934-0.0011811770.9988188
ENST00000326495ENST00000541050SSH1chr12109186062-CORO1Cchr12109055934-0.0029015420.99709845

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Fusion Genomic Features for SSH1-CORO1C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SSH1-CORO1C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:109251204/chr12:109095099)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CORO1C

Q9ULV4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (By similarity). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission (PubMed:30220460). Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (PubMed:30220460). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (By similarity). Required for normal distribution of mitochondria within cells (By similarity). {ECO:0000250|UniProtKB:Q9WUM4, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950, ECO:0000269|PubMed:30220460}.; FUNCTION: [Isoform 3]: Involved in myogenic differentiation. {ECO:0000269|PubMed:19651142}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSSH1chr12:109186062chr12:109055934ENST00000326495-1415308_4496311050.0DomainTyrosine-protein phosphatase
TgeneCORO1Cchr12:109186062chr12:109055934ENST00000261401211436_474106475.0Coiled coilOntology_term=ECO:0000269
TgeneCORO1Cchr12:109186062chr12:109055934ENST00000420959211436_474159528.0Coiled coilOntology_term=ECO:0000269
TgeneCORO1Cchr12:109186062chr12:109055934ENST00000541050211436_474106475.0Coiled coilOntology_term=ECO:0000269
TgeneCORO1Cchr12:109186062chr12:109055934ENST00000549772211436_474112481.0Coiled coilOntology_term=ECO:0000269
TgeneCORO1Cchr12:109186062chr12:109055934ENST00000261401211128_168106475.0RepeatWD 3
TgeneCORO1Cchr12:109186062chr12:109055934ENST00000261401211172_202106475.0RepeatWD 4
TgeneCORO1Cchr12:109186062chr12:109055934ENST00000261401211215_249106475.0RepeatWD 5
TgeneCORO1Cchr12:109186062chr12:109055934ENST00000261401211263_303106475.0RepeatWD 6
TgeneCORO1Cchr12:109186062chr12:109055934ENST00000420959211172_202159528.0RepeatWD 4
TgeneCORO1Cchr12:109186062chr12:109055934ENST00000420959211215_249159528.0RepeatWD 5
TgeneCORO1Cchr12:109186062chr12:109055934ENST00000420959211263_303159528.0RepeatWD 6
TgeneCORO1Cchr12:109186062chr12:109055934ENST00000541050211128_168106475.0RepeatWD 3
TgeneCORO1Cchr12:109186062chr12:109055934ENST00000541050211172_202106475.0RepeatWD 4
TgeneCORO1Cchr12:109186062chr12:109055934ENST00000541050211215_249106475.0RepeatWD 5
TgeneCORO1Cchr12:109186062chr12:109055934ENST00000541050211263_303106475.0RepeatWD 6
TgeneCORO1Cchr12:109186062chr12:109055934ENST00000549772211128_168112481.0RepeatWD 3
TgeneCORO1Cchr12:109186062chr12:109055934ENST00000549772211172_202112481.0RepeatWD 4
TgeneCORO1Cchr12:109186062chr12:109055934ENST00000549772211215_249112481.0RepeatWD 5
TgeneCORO1Cchr12:109186062chr12:109055934ENST00000549772211263_303112481.0RepeatWD 6

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSSH1chr12:109186062chr12:109055934ENST00000326470-113308_4490704.0DomainTyrosine-protein phosphatase
HgeneSSH1chr12:109186062chr12:109055934ENST00000360239-1314308_449319738.0DomainTyrosine-protein phosphatase
HgeneSSH1chr12:109186062chr12:109055934ENST00000551165-114308_4490693.0DomainTyrosine-protein phosphatase
TgeneCORO1Cchr12:109186062chr12:109055934ENST0000026140121125_70106475.0RepeatWD 1
TgeneCORO1Cchr12:109186062chr12:109055934ENST0000026140121178_118106475.0RepeatWD 2
TgeneCORO1Cchr12:109186062chr12:109055934ENST00000420959211128_168159528.0RepeatWD 3
TgeneCORO1Cchr12:109186062chr12:109055934ENST0000042095921125_70159528.0RepeatWD 1
TgeneCORO1Cchr12:109186062chr12:109055934ENST0000042095921178_118159528.0RepeatWD 2
TgeneCORO1Cchr12:109186062chr12:109055934ENST0000054105021125_70106475.0RepeatWD 1
TgeneCORO1Cchr12:109186062chr12:109055934ENST0000054105021178_118106475.0RepeatWD 2
TgeneCORO1Cchr12:109186062chr12:109055934ENST0000054977221125_70112481.0RepeatWD 1
TgeneCORO1Cchr12:109186062chr12:109055934ENST0000054977221178_118112481.0RepeatWD 2


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Fusion Gene Sequence for SSH1-CORO1C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>86755_86755_1_SSH1-CORO1C_SSH1_chr12_109186062_ENST00000326495_CORO1C_chr12_109055934_ENST00000261401_length(transcript)=5388nt_BP=1987nt
CGGCTCCAGGAGGCCCCGGGCCCGGCCCGGGCGGCGGTGGCGGTGGCGGCTCTAGCTCGAGACGTCTGTGGCGCCCTCGCACCGCGCCGC
AGCCATGGCCCTGGTGACCCTGCAGCGCTCGCCCACGCCCAGCGCCGCCTCCTCCTCGGCCAGCAACAGCGAGTTGGAGGCTGGCAGCGA
AGAAGATCGAAAATTAAACCTCAGCTTAAGTGAGAGCTTTTTCATGGTGAAAGGCGCAGCCCTCTTCTTACAACAGGGAAGCAGCCCTCA
AGGCCAGCGGAGTCTTCAGCACCCCCACAAGCATGCAGGTGATCTGCCTCAACATCTTCAGGTGATGATCAACCTTCTGCGTTGCGAAGA
CAGAATCAAGCTGGCAGTGCGCCTGGAGAGCGCCTGGGCGGACCGGGTCCGGTACATGGTGGTGGTGTACAGCAGCGGGCGCCAGGACAC
CGAGGAGAATATCTTGCTGGGAGTGGACTTTTCCAGTAAGGAAAGTAAAAGCTGCACCATTGGGATGGTTCTCCGACTGTGGAGCGACAC
GAAAATCCACCTTGATGGAGATGGTGGGTTCAGCGTGAGCACAGCAGGAAGGATGCACATATTTAAGCCTGTGTCTGTCCAGGCCATGTG
GTCTGCCCTGCAGGTGCTTCACAAGGCCTGCGAAGTGGCCCGGAGGCACAACTACTTCCCCGGGGGTGTAGCTCTCATCTGGGCTACCTA
CTATGAGAGCTGCATCAGCTCCGAGCAGAGCTGCATCAACGAGTGGAACGCCATGCAGGACCTGGAGTCTACGCGGCCCGACTCCCCCGC
GCTATTTGTGGACAAGCCCACTGAAGGGGAAAGGACCGAGCGCCTCATCAAAGCCAAGCTCCGAAGCATCATGATGAGCCAGGATCTAGA
AAATGTGACTTCCAAAGAGATTCGTAATGAATTAGAGAAACAGATGAATTGTAACTTGAAGGAACTCAAGGAATTTATAGACAATGAGAT
GCTACTTATCTTGGGACAGATGGACAAGCCCTCCCTTATCTTCGATCATCTTTATCTCGGCTCTGAATGGAATGCATCCAATCTGGAGGA
ACTGCAGGGCTCAGGGGTTGATTACATTTTAAATGTTACCAGAGAAATCGATAATTTTTTTCCTGGCTTATTTGCATATCATAACATCCG
AGTCTACGATGAAGAGACCACAGACCTCCTCGCCCACTGGAATGAAGCGTATCATTTTATAAACAAAGCGAAGAGGAACCATTCCAAGTG
CCTGGTGCATTGCAAAATGGGCGTGAGTCGCTCGGCCTCCACAGTCATAGCCTATGCAATGAAGGAATTCGGCTGGCCTCTGGAAAAAGC
ATATAACTATGTAAAGCAGAAGCGCAGCATCACGCGCCCCAACGCGGGCTTTATGAGGCAGCTGTCTGAGTATGAAGGCATCTTGGATGC
AAGCAAACAGCGGCACAACAAGCTGTGGCGTCAGCAGACAGACAGCAGCCTCCAGCAGCCTGTGGATGACCCTGCAGGACCTGGCGACTT
CTTGCCAGAGACCCCAGATGGCACCCCGGAAAGCCAGCTGCCCTTCTTGGATGATGCCGCCCAGCCCGGCTTAGGGCCCCCCCTCCCCTG
CTGTTTCCGGCGACTCTCAGACCCCCTTCTGCCTTCCCCTGAGGATGAAACTGGCAGCTTGGTCCACCTGGAGGATCCGGAGAGGGAGGC
TCTGTTGGAGGAAGCTGCTCCACCTGCAGAGGTGCACAGGCCGGCCAGACAGCCCCAGCAAGGTTCCGGACTCTGTGAGAAGGATGTGAA
GAAGAAACTAGAGTTTGGGAGTCCCAAAGGTCGGAGCGGCTCCTTGCTGCAGGTGGAGGAGACGGAAAGGGAGGAGGGCCTGGGAGCAGG
GAGGTGGGGGCAGCTTCCAACCCAGCTCGATCAAAACCTGCTCAACTCGGAGAACCTAAACAACAACAGCAAGAGGAGCTGTCCCAACGG
CATGGAGGTATGGCAGATCCCAGAAAATGGACTCACCCTTTCCCTGACTGAACCTGTGGTGATTTTGGAAGGCCACTCAAAGAGAGTCGG
CATCGTGGCTTGGCATCCAACGGCCCGCAATGTGCTTCTTAGTGCAGGCTGTGATAATGCCATTATCATCTGGAATGTGGGAACAGGGGA
AGCCCTTATAAACTTGGACGATATGCATTCAGACATGATTTACAATGTGAGCTGGAACCGGAATGGCAGTCTGATCTGCACAGCTTCCAA
AGACAAGAAAGTGAGAGTCATTGATCCCAGGAAACAAGAGATTGTTGCTGAGAAGGAGAAAGCACATGAAGGAGCAAGACCCATGAGAGC
CATCTTCCTGGCCGATGGCAATGTCTTCACCACTGGGTTCAGCCGCATGAGCGAGCGGCAGCTGGCTCTCTGGAATCCGAAAAATATGCA
GGAACCAATTGCTCTTCATGAGATGGACACTAGCAATGGGGTGTTGCTGCCTTTCTATGACCCTGACACCAGCATCATTTACTTATGTGG
AAAGGGTGACAGCAGTATTCGCTATTTTGAGATCACGGATGAATCCCCGTACGTCCACTACCTCAACACATTCAGCAGCAAGGAGCCTCA
GAGAGGGATGGGTTACATGCCCAAGAGGGGACTTGATGTTAACAAATGTGAGATTGCCAGATTCTTCAAACTTCATGAGAGAAAGTGTGA
ACCTATTATTATGACTGTTCCCAGGAAGTCTGACCTTTTCCAAGATGACCTGTATCCTGACACAGCGGGGCCAGAGGCCGCGCTGGAGGC
AGAAGAGTGGTTCGAAGGCAAGAATGCAGACCCAATCCTCATCTCCTTGAAGCACGGGTACATTCCAGGCAAAAACAGGGATCTCAAGGT
GGTCAAGAAGAACATTCTGGATAGCAAGCCCACTGCAAACAAGAAGTGCGACCTGATCAGCATCCCCAAGAAAACCACAGACACGGCCAG
TGTGCAAAATGAAGCCAAGTTGGATGAGATTTTAAAAGAGATCAAATCTATAAAAGACACAATCTGCAATCAAGATGAGCGTATTTCCAA
GTTAGAACAGCAGATGGCAAAGATAGCAGCCTGAAGGTCCCACCCCCACCCCTACAGAAAAAATGGGAGCAAGAACTTGTGCTTGGGAGC
TGGTTATTGGTGTGGTCCTAGGGAGGGCGGAAAGGGAGGCACTGCCATTTGGAGACATTCCATTTCAGATTTGTCAACCAGCGATAGGCC
ACATTCCAGTAAGAACTCAATTTGTCTCCCAAATTTGCAGAAACAAAACGTGATTTAAAAGCTGAGCTTTTTATCAGAAAGCTTTTTTGA
TGTTTTAAGTGTTATGTGACTTGTTGAACTTTTTAAAAAGTGCTACTTTTAAAATCCCAGATACTCTGAATTTTAGAAAACAAACTAATT
CTGATTGTGTCGTGCCCAAGTACCCTTTTTTTTTTAATGAATAGGGACCAATGCCACATTGCTTTTTATATTTCTTTCTTTTTTAATGTT
GCCAAAACCAAAAGTAGCTTTGTTTTCCTTTGTATTTTGCTACTTTGCAGTATTTGTGTGTGTGGTTTTTTTTCCTTAATTTGAAAGGGA
CAGCACTGTGTATGTTTATAAACTAAATGAAGATAAGATATTATTTTGTATAAACATTCATCTGAGAACAATCAAAGCAGTAGCCACATG
GTGCTGGCTCCTTTGCAGCACAAACCTGGTCATTTTGATGACTGTACAACAGGAAGACTTGAAAAATCACGTGGATTCATATTACCACCG
CTCTCATTTCATGGAGTCTTCTGATCAAAAAAGCTCACGTCGTATTTCTTCTTTTCCTTTCTCTTTTCTAGAAATTGGGTGTTTGTACCA
GAATGGAATTTTGCTTCTCGGTTATCCTGTGCTTCAGATGATTATAATCTAACCCAAACTAGCATGTGTTTCTGCAGTTTGTTACACACC
TAGGATCATATTGCATTCATCACTTTAAACATCATGTTTCAGGTTTTGGTCAATACTTGACAAGGGTGCCCAGGACAGGAAGACGTGTAC
TGCTGAGTGTTCCTTCTTGCCCTTTTCAGCAGCTTGCCCAGCTCTTGAGTACAGTGGTGGGGACTAAAAATGTGGGCATGTGGAGAGGGG
TATTTGCCCTGGGTGATCCTGTTTCCCTGTGCTGTCCCCATGCTGTGTTGGAGGAGGAAGTGGCTCTCCTTCCACCAACAAAGCTCCTGC
TCTACCCTCTTCCTCACATGTGCTGCGACCTCTCTCAGGGCTCCCCCAGCCATTCCTTCTTTCCTTCCTGCCTTTTAGCTCTAACCACAT
TAAGCTAAGACAAGGCCAGAGGGTGCGATTGAATGAGTATTGAGACTGAGGAGAATGATAGAGAGTGAAGCAGAAACAGGAGCACAGACC
TCTGCTGTAGCTTTAATGCATACAAACATGTCCCTCCGCACAACTAACCTGCCCTGCCTCTCCATCTCTCACCAAGGCTGCGTCAAAGCA
CAGAGGCTCCCCGGACTCGGAGGGGGCCAGAGACTGAGCTCTGGTCACCTGTTCATTCCTCGGTTAGCTGGAACTTTGCCCCGTTTCCAG
TTTCTTATAGTGCATGCTTGGGAAACAAGATTTAAGGAGCCTCTGTTTTGGAAGGGCTGTCTGTGATTGAACGTGAAATGTGTAGTGCCA
TTGGGACCACGAAGGGAATTCTTGCACATGCTCGTGCTGGTGTGGGCATGGGACTGGCTGGAAACGTCTGTATGCAGGGAGCCAGGGTGA
GGGCAGAGTGTGGTGACAGCCGAACTTGGAGTAATGTCCGTGTAGAAAAAGGACCATGTTCTTATCCAGCCAATACTGGGAGTGCTGTCT
CCACAATTTCAGGGCATCTGAATGTTTGATGTGGTTTTGTGTGTGTGTATGTATGTGTTTAATATTGAAGTGGATCATGAGATGTAAAGA
AAACAATAATGGCAATGACTTATATTCAAATCTGTATTTGTTTCTTTATCAATGTAATCTGCTGAGGACCTTTTGTCTAAGATTCAGTAG
TGTTTTAAGGTTCTGATATCGAATTAATGAAGTAAAGTTGTTGATGGTGGTGAAACACCGTAGGGCATGTGGTTCAAAGAGAAGCAGGAG
GGCAAGGGAAAGTTACCCTGATCTTAGTTTGTAGCTTATGACTTATTTAATGAATGGATGCCCAGCCAAGCTCAGAGTAGGCGCCCAAAG
CATTGTGGATTATTTTCCTGTTTTGTCTTTTTTTTTTTTTTTTTTTAAGCCATGACATCCCAGAAGAGGACAGTGAATTACTCCTAGGTC

>86755_86755_1_SSH1-CORO1C_SSH1_chr12_109186062_ENST00000326495_CORO1C_chr12_109055934_ENST00000261401_length(amino acids)=999AA_BP=0
MALVTLQRSPTPSAASSSASNSELEAGSEEDRKLNLSLSESFFMVKGAALFLQQGSSPQGQRSLQHPHKHAGDLPQHLQVMINLLRCEDR
IKLAVRLESAWADRVRYMVVVYSSGRQDTEENILLGVDFSSKESKSCTIGMVLRLWSDTKIHLDGDGGFSVSTAGRMHIFKPVSVQAMWS
ALQVLHKACEVARRHNYFPGGVALIWATYYESCISSEQSCINEWNAMQDLESTRPDSPALFVDKPTEGERTERLIKAKLRSIMMSQDLEN
VTSKEIRNELEKQMNCNLKELKEFIDNEMLLILGQMDKPSLIFDHLYLGSEWNASNLEELQGSGVDYILNVTREIDNFFPGLFAYHNIRV
YDEETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSASTVIAYAMKEFGWPLEKAYNYVKQKRSITRPNAGFMRQLSEYEGILDAS
KQRHNKLWRQQTDSSLQQPVDDPAGPGDFLPETPDGTPESQLPFLDDAAQPGLGPPLPCCFRRLSDPLLPSPEDETGSLVHLEDPEREAL
LEEAAPPAEVHRPARQPQQGSGLCEKDVKKKLEFGSPKGRSGSLLQVEETEREEGLGAGRWGQLPTQLDQNLLNSENLNNNSKRSCPNGM
EVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLDDMHSDMIYNVSWNRNGSLICTASKD
KKVRVIDPRKQEIVAEKEKAHEGARPMRAIFLADGNVFTTGFSRMSERQLALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGK
GDSSIRYFEITDESPYVHYLNTFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERKCEPIIMTVPRKSDLFQDDLYPDTAGPEAALEAE
EWFEGKNADPILISLKHGYIPGKNRDLKVVKKNILDSKPTANKKCDLISIPKKTTDTASVQNEAKLDEILKEIKSIKDTICNQDERISKL

--------------------------------------------------------------
>86755_86755_2_SSH1-CORO1C_SSH1_chr12_109186062_ENST00000326495_CORO1C_chr12_109055934_ENST00000541050_length(transcript)=3930nt_BP=1987nt
CGGCTCCAGGAGGCCCCGGGCCCGGCCCGGGCGGCGGTGGCGGTGGCGGCTCTAGCTCGAGACGTCTGTGGCGCCCTCGCACCGCGCCGC
AGCCATGGCCCTGGTGACCCTGCAGCGCTCGCCCACGCCCAGCGCCGCCTCCTCCTCGGCCAGCAACAGCGAGTTGGAGGCTGGCAGCGA
AGAAGATCGAAAATTAAACCTCAGCTTAAGTGAGAGCTTTTTCATGGTGAAAGGCGCAGCCCTCTTCTTACAACAGGGAAGCAGCCCTCA
AGGCCAGCGGAGTCTTCAGCACCCCCACAAGCATGCAGGTGATCTGCCTCAACATCTTCAGGTGATGATCAACCTTCTGCGTTGCGAAGA
CAGAATCAAGCTGGCAGTGCGCCTGGAGAGCGCCTGGGCGGACCGGGTCCGGTACATGGTGGTGGTGTACAGCAGCGGGCGCCAGGACAC
CGAGGAGAATATCTTGCTGGGAGTGGACTTTTCCAGTAAGGAAAGTAAAAGCTGCACCATTGGGATGGTTCTCCGACTGTGGAGCGACAC
GAAAATCCACCTTGATGGAGATGGTGGGTTCAGCGTGAGCACAGCAGGAAGGATGCACATATTTAAGCCTGTGTCTGTCCAGGCCATGTG
GTCTGCCCTGCAGGTGCTTCACAAGGCCTGCGAAGTGGCCCGGAGGCACAACTACTTCCCCGGGGGTGTAGCTCTCATCTGGGCTACCTA
CTATGAGAGCTGCATCAGCTCCGAGCAGAGCTGCATCAACGAGTGGAACGCCATGCAGGACCTGGAGTCTACGCGGCCCGACTCCCCCGC
GCTATTTGTGGACAAGCCCACTGAAGGGGAAAGGACCGAGCGCCTCATCAAAGCCAAGCTCCGAAGCATCATGATGAGCCAGGATCTAGA
AAATGTGACTTCCAAAGAGATTCGTAATGAATTAGAGAAACAGATGAATTGTAACTTGAAGGAACTCAAGGAATTTATAGACAATGAGAT
GCTACTTATCTTGGGACAGATGGACAAGCCCTCCCTTATCTTCGATCATCTTTATCTCGGCTCTGAATGGAATGCATCCAATCTGGAGGA
ACTGCAGGGCTCAGGGGTTGATTACATTTTAAATGTTACCAGAGAAATCGATAATTTTTTTCCTGGCTTATTTGCATATCATAACATCCG
AGTCTACGATGAAGAGACCACAGACCTCCTCGCCCACTGGAATGAAGCGTATCATTTTATAAACAAAGCGAAGAGGAACCATTCCAAGTG
CCTGGTGCATTGCAAAATGGGCGTGAGTCGCTCGGCCTCCACAGTCATAGCCTATGCAATGAAGGAATTCGGCTGGCCTCTGGAAAAAGC
ATATAACTATGTAAAGCAGAAGCGCAGCATCACGCGCCCCAACGCGGGCTTTATGAGGCAGCTGTCTGAGTATGAAGGCATCTTGGATGC
AAGCAAACAGCGGCACAACAAGCTGTGGCGTCAGCAGACAGACAGCAGCCTCCAGCAGCCTGTGGATGACCCTGCAGGACCTGGCGACTT
CTTGCCAGAGACCCCAGATGGCACCCCGGAAAGCCAGCTGCCCTTCTTGGATGATGCCGCCCAGCCCGGCTTAGGGCCCCCCCTCCCCTG
CTGTTTCCGGCGACTCTCAGACCCCCTTCTGCCTTCCCCTGAGGATGAAACTGGCAGCTTGGTCCACCTGGAGGATCCGGAGAGGGAGGC
TCTGTTGGAGGAAGCTGCTCCACCTGCAGAGGTGCACAGGCCGGCCAGACAGCCCCAGCAAGGTTCCGGACTCTGTGAGAAGGATGTGAA
GAAGAAACTAGAGTTTGGGAGTCCCAAAGGTCGGAGCGGCTCCTTGCTGCAGGTGGAGGAGACGGAAAGGGAGGAGGGCCTGGGAGCAGG
GAGGTGGGGGCAGCTTCCAACCCAGCTCGATCAAAACCTGCTCAACTCGGAGAACCTAAACAACAACAGCAAGAGGAGCTGTCCCAACGG
CATGGAGGTATGGCAGATCCCAGAAAATGGACTCACCCTTTCCCTGACTGAACCTGTGGTGATTTTGGAAGGCCACTCAAAGAGAGTCGG
CATCGTGGCTTGGCATCCAACGGCCCGCAATGTGCTTCTTAGTGCAGGCTGTGATAATGCCATTATCATCTGGAATGTGGGAACAGGGGA
AGCCCTTATAAACTTGGACGATATGCATTCAGACATGATTTACAATGTGAGCTGGAACCGGAATGGCAGTCTGATCTGCACAGCTTCCAA
AGACAAGAAAGTGAGAGTCATTGATCCCAGGAAACAAGAGATTGTTGCTGAGAAGGAGAAAGCACATGAAGGAGCAAGACCCATGAGAGC
CATCTTCCTGGCCGATGGCAATGTCTTCACCACTGGGTTCAGCCGCATGAGCGAGCGGCAGCTGGCTCTCTGGAATCCGAAAAATATGCA
GGAACCAATTGCTCTTCATGAGATGGACACTAGCAATGGGGTGTTGCTGCCTTTCTATGACCCTGACACCAGCATCATTTACTTATGTGG
AAAGGGTGACAGCAGTATTCGCTATTTTGAGATCACGGATGAATCCCCGTACGTCCACTACCTCAACACATTCAGCAGCAAGGAGCCTCA
GAGAGGGATGGGTTACATGCCCAAGAGGGGACTTGATGTTAACAAATGTGAGATTGCCAGATTCTTCAAACTTCATGAGAGAAAGTGTGA
ACCTATTATTATGACTGTTCCCAGGAAGTCTGACCTTTTCCAAGATGACCTGTATCCTGACACAGCGGGGCCAGAGGCCGCGCTGGAGGC
AGAAGAGTGGTTCGAAGGCAAGAATGCAGACCCAATCCTCATCTCCTTGAAGCACGGGTACATTCCAGGCAAAAACAGGGATCTCAAGGT
GGTCAAGAAGAACATTCTGGATAGCAAGCCCACTGCAAACAAGAAGTGCGACCTGATCAGCATCCCCAAGAAAACCACAGACACGGCCAG
TGTGCAAAATGAAGCCAAGTTGGATGAGATTTTAAAAGAGATCAAATCTATAAAAGACACAATCTGCAATCAAGATGAGCGTATTTCCAA
GTTAGAACAGCAGATGGCAAAGATAGCAGCCTGAAGGTCCCACCCCCACCCCTACAGAAAAAATGGGAGCAAGAACTTGTGCTTGGGAGC
TGGTTATTGGTGTGGTCCTAGGGAGGGCGGAAAGGGAGGCACTGCCATTTGGAGACATTCCATTTCAGATTTGTCAACCAGCGATAGGCC
ACATTCCAGTAAGAACTCAATTTGTCTCCCAAATTTGCAGAAACAAAACGTGATTTAAAAGCTGAGCTTTTTATCAGAAAGCTTTTTTGA
TGTTTTAAGTGTTATGTGACTTGTTGAACTTTTTAAAAAGTGCTACTTTTAAAATCCCAGATACTCTGAATTTTAGAAAACAAACTAATT
CTGATTGTGTCGTGCCCAAGTACCCTTTTTTTTTTAATGAATAGGGACCAATGCCACATTGCTTTTTATATTTCTTTCTTTTTTAATGTT
GCCAAAACCAAAAGTAGCTTTGTTTTCCTTTGTATTTTGCTACTTTGCAGTATTTGTGTGTGTGGTTTTTTTTCCTTAATTTGAAAGGGA
CAGCACTGTGTATGTTTATAAACTAAATGAAGATAAGATATTATTTTGTATAAACATTCATCTGAGAACAATCAAAGCAGTAGCCACATG
GTGCTGGCTCCTTTGCAGCACAAACCTGGTCATTTTGATGACTGTACAACAGGAAGACTTGAAAAATCACGTGGATTCATATTACCACCG
CTCTCATTTCATGGAGTCTTCTGATCAAAAAAGCTCACGTCGTATTTCTTCTTTTCCTTTCTCTTTTCTAGAAATTGGGTGTTTGTACCA

>86755_86755_2_SSH1-CORO1C_SSH1_chr12_109186062_ENST00000326495_CORO1C_chr12_109055934_ENST00000541050_length(amino acids)=999AA_BP=0
MALVTLQRSPTPSAASSSASNSELEAGSEEDRKLNLSLSESFFMVKGAALFLQQGSSPQGQRSLQHPHKHAGDLPQHLQVMINLLRCEDR
IKLAVRLESAWADRVRYMVVVYSSGRQDTEENILLGVDFSSKESKSCTIGMVLRLWSDTKIHLDGDGGFSVSTAGRMHIFKPVSVQAMWS
ALQVLHKACEVARRHNYFPGGVALIWATYYESCISSEQSCINEWNAMQDLESTRPDSPALFVDKPTEGERTERLIKAKLRSIMMSQDLEN
VTSKEIRNELEKQMNCNLKELKEFIDNEMLLILGQMDKPSLIFDHLYLGSEWNASNLEELQGSGVDYILNVTREIDNFFPGLFAYHNIRV
YDEETTDLLAHWNEAYHFINKAKRNHSKCLVHCKMGVSRSASTVIAYAMKEFGWPLEKAYNYVKQKRSITRPNAGFMRQLSEYEGILDAS
KQRHNKLWRQQTDSSLQQPVDDPAGPGDFLPETPDGTPESQLPFLDDAAQPGLGPPLPCCFRRLSDPLLPSPEDETGSLVHLEDPEREAL
LEEAAPPAEVHRPARQPQQGSGLCEKDVKKKLEFGSPKGRSGSLLQVEETEREEGLGAGRWGQLPTQLDQNLLNSENLNNNSKRSCPNGM
EVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLDDMHSDMIYNVSWNRNGSLICTASKD
KKVRVIDPRKQEIVAEKEKAHEGARPMRAIFLADGNVFTTGFSRMSERQLALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGK
GDSSIRYFEITDESPYVHYLNTFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERKCEPIIMTVPRKSDLFQDDLYPDTAGPEAALEAE
EWFEGKNADPILISLKHGYIPGKNRDLKVVKKNILDSKPTANKKCDLISIPKKTTDTASVQNEAKLDEILKEIKSIKDTICNQDERISKL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SSH1-CORO1C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSSH1chr12:109186062chr12:109055934ENST00000326470-113897_10490704.0YWHAG
HgeneSSH1chr12:109186062chr12:109055934ENST00000326495-1415897_1049631.01050.0YWHAG
HgeneSSH1chr12:109186062chr12:109055934ENST00000360239-1314897_1049319.0738.0YWHAG
HgeneSSH1chr12:109186062chr12:109055934ENST00000551165-114897_10490693.0YWHAG


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SSH1-CORO1C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SSH1-CORO1C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource