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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SSH2-HP1BP3 (FusionGDB2 ID:86777)

Fusion Gene Summary for SSH2-HP1BP3

Fusion gene summary

Fusion gene information	Fusion gene name: SSH2-HP1BP3
	Fusion gene ID: 86777
		Hgene	Tgene
	Gene symbol	SSH2	HP1BP3
	Gene ID	85464	50809
	Gene name	slingshot protein phosphatase 2	heterochromatin protein 1 binding protein 3
	Synonyms	SSH-2\|SSH-2L	HP1-BP74\|HP1BP74
	Cytomap	17q11.2	1p36.12
	Type of gene	protein-coding	protein-coding
	Description	protein phosphatase Slingshot homolog 2SSH-like protein 2	heterochromatin protein 1-binding protein 3
	Modification date	20200313	20200313
	UniProtAcc	.	Q5SSJ5
	Ensembl transtripts involved in fusion gene	ENST00000269033, ENST00000540801, ENST00000324677, ENST00000579954, ENST00000582084, ENST00000590153,	ENST00000375003, ENST00000375000, ENST00000487117, ENST00000312239,
Fusion gene scores	* DoF score	39 X 23 X 10=8970	22 X 14 X 10=3080
	# samples	48	24
	** MAII score	log2(48/8970*10)=-4.22400167419811 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(24/3080*10)=-3.68182403997374 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SSH2 [Title/Abstract] AND HP1BP3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SSH2(27982578)-HP1BP3(21100103), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	HP1BP3	GO:0071456	cellular response to hypoxia	25100860

Fusion gene breakpoints across SSH2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HP1BP3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-L5-A8NQ	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-

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Fusion Gene ORF analysis for SSH2-HP1BP3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000269033	ENST00000375003	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-
5CDS-5UTR	ENST00000540801	ENST00000375003	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-
5CDS-intron	ENST00000269033	ENST00000375000	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-
5CDS-intron	ENST00000269033	ENST00000487117	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-
5CDS-intron	ENST00000540801	ENST00000375000	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-
5CDS-intron	ENST00000540801	ENST00000487117	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-
In-frame	ENST00000269033	ENST00000312239	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-
In-frame	ENST00000540801	ENST00000312239	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-
intron-3CDS	ENST00000324677	ENST00000312239	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-
intron-3CDS	ENST00000579954	ENST00000312239	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-
intron-3CDS	ENST00000582084	ENST00000312239	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-
intron-3CDS	ENST00000590153	ENST00000312239	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-
intron-5UTR	ENST00000324677	ENST00000375003	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-
intron-5UTR	ENST00000579954	ENST00000375003	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-
intron-5UTR	ENST00000582084	ENST00000375003	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-
intron-5UTR	ENST00000590153	ENST00000375003	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-
intron-intron	ENST00000324677	ENST00000375000	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-
intron-intron	ENST00000324677	ENST00000487117	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-
intron-intron	ENST00000579954	ENST00000375000	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-
intron-intron	ENST00000579954	ENST00000487117	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-
intron-intron	ENST00000582084	ENST00000375000	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-
intron-intron	ENST00000582084	ENST00000487117	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-
intron-intron	ENST00000590153	ENST00000375000	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-
intron-intron	ENST00000590153	ENST00000487117	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000269033	SSH2	chr17	27982578	-	ENST00000312239	HP1BP3	chr1	21100103	-	4598	1150	152	2461	769
ENST00000540801	SSH2	chr17	27982578	-	ENST00000312239	HP1BP3	chr1	21100103	-	4620	1172	93	2483	796

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000269033	ENST00000312239	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-	0.001307208	0.9986928
ENST00000540801	ENST00000312239	SSH2	chr17	27982578	-	HP1BP3	chr1	21100103	-	0.000508703	0.99949133

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Fusion Genomic Features for SSH2-HP1BP3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SSH2-HP1BP3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:27982578/chr1:21100103)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	HP1BP3 Q5SSJ5
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal(PubMed:25100860). {ECO:0000269\|PubMed:24830416, ECO:0000269\|PubMed:25100860}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

HP1BP3

chr17:27982578

chr1:21100103

ENST00000312239

454_553

116

554.0

Compositional bias

Note=Lys-rich

Tgene

HP1BP3

chr17:27982578

chr1:21100103

ENST00000375000

454_553

134.0

Compositional bias

Note=Lys-rich

Tgene

HP1BP3

chr17:27982578

chr1:21100103

ENST00000375003

454_553

402.0

Compositional bias

Note=Lys-rich

Tgene

HP1BP3

chr17:27982578

chr1:21100103

ENST00000312239

157_232

116

554.0

Domain

H15 1

Tgene

HP1BP3

chr17:27982578

chr1:21100103

ENST00000312239

255_330

116

554.0

Domain

H15 2

Tgene

HP1BP3

chr17:27982578

chr1:21100103

ENST00000312239

337_413

116

554.0

Domain

H15 3

Tgene

HP1BP3

chr17:27982578

chr1:21100103

ENST00000375000

157_232

134.0

Domain

H15 1

Tgene

HP1BP3

chr17:27982578

chr1:21100103

ENST00000375000

255_330

134.0

Domain

H15 2

Tgene

HP1BP3

chr17:27982578

chr1:21100103

ENST00000375000

337_413

134.0

Domain

H15 3

Tgene

HP1BP3

chr17:27982578

chr1:21100103

ENST00000375003

157_232

402.0

Domain

H15 1

Tgene

HP1BP3

chr17:27982578

chr1:21100103

ENST00000375003

255_330

402.0

Domain

H15 2

Tgene

HP1BP3

chr17:27982578

chr1:21100103

ENST00000375003

337_413

402.0

Domain

H15 3

Tgene

HP1BP3

chr17:27982578

chr1:21100103

ENST00000312239

255_259

116

554.0

Motif

PxVxL motif

Tgene

HP1BP3

chr17:27982578

chr1:21100103

ENST00000375000

255_259

134.0

Motif

PxVxL motif

Tgene

HP1BP3

chr17:27982578

chr1:21100103

ENST00000375003

255_259

402.0

Motif

PxVxL motif

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SSH2

chr17:27982578

chr1:21100103

ENST00000269033

307_448

332

1424.0

Domain

Tyrosine-protein phosphatase

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Fusion Gene Sequence for SSH2-HP1BP3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>86777_86777_1_SSH2-HP1BP3_SSH2_chr17_27982578_ENST00000269033_HP1BP3_chr1_21100103_ENST00000312239_length(transcript)=4598nt_BP=1150nt
GCGGAGTCTGCGGCCGTTCCCGCGGCCTCCTCCTCCTCCCCGTTCCCTTCACCCCCACCCCGCACCCCTTTCCCCATCCCGGCTCCGTCA
CCCTCCCGTCCCCCACACTCAGGACAAGAATGCCCTGCCCGGAACAACCCAGCAGCGCCTAGATGGCTTTGGTCACGGTCCAGCGGTCAC
CTACCCCCAGCACCACCTCCAGCCCCTGCGCCTCGGAGGCAGACAGTGGGGAGGAAGAATGCCGGTCACAGCCCAGGAGCATCAGCGAGA
GCTTTCTAACTGTCAAAGGTGCTGCCCTTTTTCTACCACGGGGAAATGGCTCATCCACACCAAGAATCAGCCACAGACGGAACAAGCATG
CAGGCGATCTCCAACAGCATCTCCAAGCAATGTTCATTTTACTCCGCCCAGAAGACAACATCAGGCTGGCTGTAAGACTGGAAAGTACTT
ACCAGAATCGAACACGCTATATGGTAGTGGTTTCAACTAATGGTAGACAAGACACTGAAGAAAGCATCGTCCTAGGAATGGATTTCTCCT
CTAATGACAGTAGCACTTGTACCATGGGCTTAGTTTTGCCTCTCTGGAGCGACACGCTAATTCATTTGGATGGTGATGGTGGGTTCAGTG
TATCGACGGATAACAGAGTTCACATATTCAAACCTGTATCTGTGCAGGCAATGTGGTCTGCACTACAGAGCTTACACAAGGCTTGTGAAG
TCGCCAGAGCGCATAACTACTACCCAGGCAGCCTATTTCTCACTTGGGTGAGTTATTATGAGAGCCATATCAACTCAGATCAATCCTCAG
TCAATGAATGGAATGCAATGCAAGATGTACAGTCCCACCGGCCCGACTCTCCAGCTCTCTTCACCGACATACCTACTGAACGTGAACGAA
CAGAAAGGCTAATTAAAACCAAATTAAGGGAGATCATGATGCAGAAGGATTTGGAGAATATTACATCCAAAGAGATAAGAACAGAGTTGG
AAATGCAAATGGTGTGCAACTTGCGGGAATTCAAGGAATTTATAGACAATGAAATGATAGTGATCCTTGGTCAAATGGATAGCCCTACAC
AGATATTTGAGCATGTGTTCCTGGGCTCAGAATGGAATGCCTCCAACTTAGAGGACTTACAGAACCGAGGTGAGAAAGATCAGTCTAAAG
AAAAGGAGAAGAAAGTGAAAAAAACAATTCCTTCCTGGGCTACCCTTTCTGCCAGCCAGCTAGCCAGGGCCCAGAAACAAACACCGATGG
CTTCTTCCCCACGTCCCAAGATGGATGCAATCTTAACTGAGGCCATTAAGGCATGCTTCCAGAAGAGTGGTGCATCAGTGGTTGCTATTC
GAAAATACATCATCCATAAGTATCCTTCTCTGGAGCTGGAGAGAAGGGGTTATCTCCTTAAACAAGCACTGAAAAGAGAATTAAATAGAG
GAGTCATCAAACAGGTTAAAGGAAAAGGTGCTTCTGGAAGTTTTGTTGTGGTTCAGAAATCAAGAAAAACACCTCAGAAATCCAGAAACA
GAAAGAATAGGAGCTCTGCAGTGGATCCAGAACCACAAGTAAAATTGGAGGATGTCCTCCCACTGGCCTTTACTCGCCTTTGTGAACCTA
AAGAAGCTTCCTACAGTCTCATCAGGAAATATGTGTCTCAGTATTATCCTAAGCTTAGAGTGGACATCAGGCCTCAGCTGTTGAAGAACG
CTCTGCAGAGAGCAGTAGAGAGGGGCCAGTTAGAACAGATAACTGGCAAAGGTGCTTCGGGGACATTCCAGCTGAAGAAATCAGGGGAGA
AACCCCTGCTTGGTGGAAGCCTGATGGAATATGCAATCTTGTCTGCCATTGCTGCCATGAATGAGCCGAAGACCTGCTCTACCACTGCTC
TGAAGAAGTATGTCCTAGAGAATCACCCAGGAACCAATTCTAACTATCAAATGCATTTGCTGAAAAAAACCCTGCAGAAATGCGAAAAGA
ATGGGTGGATGGAACAGATCTCTGGGAAAGGGTTCAGTGGCACCTTCCAGCTCTGTTTTCCCTATTATCCCAGCCCAGGAGTTCTGTTTC
CGAAGAAAGAGCCAGATGATTCTAGAGATGAGGATGAAGATGAAGATGAGTCATCAGAAGAAGACTCTGAGGATGAAGAGCCGCCACCTA
AGAGAAGGTTGCAGAAGAAAACCCCAGCCAAGTCCCCAGGGAAGGCCGCATCTGTGAAGCAGAGAGGGTCCAAACCTGCACCTAAAGTCT
CAGCTGCCCAGCGGGGGAAAGCTAGGCCCTTGCCTAAGAAAGCACCTCCTAAGGCCAAAACGCCTGCCAAGAAGACCAGACCCTCATCCA
CAGTCATCAAGAAACCTAGTGGTGGCTCCTCAAAGAAGCCTGCAACCAGTGCAAGAAAGGAAGTAAAATTGCCGGGCAAGGGCAAATCCA
CCATGAAGAAGTCTTTCAGAGTGAAAAAGTAAATTTTATAGGAAAAAAGGGTATCATGATGAAATTCAAAATCTTATTTTCTAAGGTCAG
TGTGCATTTGTTTAGTTTTGATGCTTTTCAAATTACATTATTTTCCTCCCCTATGAACATTGTGGGGAGGGACTCTAAATAAACCAGTTT
AGGCATTTGCTAGCTTTAGGTGCTTTTATTGGTGCCTGCCCTTTTCCTTGTTCATTTTAATTTCTGCAATAATCCTGGACTTTCCTAAAC
TATGTAATGTATACTTGTCCTTTTTCTCTGCCTCCCCCAACCCCCTGTTGTTTTTATGGTCAGCTTTGCCTTTTTTTTTTCTTCCAATTT
TATCTAAACAGTTGCAGAGATTTTTATATTTGTAGAAAGCATCAAGAACGGTATGCCAGTCAGGTCCTGGAAGTAAAATGGAGGCACAAT
ATAGCACTGACTGAGTTGTAAAGCCTCCTGCCTGGAGACTTCAGTTATAGCTGTAATAATTAATCTTATTTATAAAAGCCACTCCACTAA
CCTTTTCTCTCCAACTGTAAACACAGAGACAGCTTTGGGAATAAGCCAAAAACAGGGTGATCTCATTAGATTTTGAAGATATATGACTCC
TTTGGGCTACATTTCATATTGATCAATTTCTAGGTATTTTTCACTGGCCCAAAGTATTGCATTCCCTTAACAGCAAGCACAAGTTCTCTA
TATCACTTGTTTTTTGTTGTTGTTGTTGTTGTCGTCGTTGTTTTGAGACGGAGTCTTGCTCAGGTGCCCCGGAGTGCAGTGGTGCAATCT
CAGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGCTTCAGCCTCCCGAGTAGCTGGGATTACAGGTGTGTACCACCACG
CCTGGCAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCGCCGTGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCAGGTGATCCGCCT
GCCTCGGCCTCCCAAAGTGCTGGGATTACAGGAGTGAGCCACTGTGCCTGGCCTATCCCACTTGGTTTTTGACTGAAGGGGAAGTGTAGA
AATATATTGATTTGTGATTTCTGGTGTCACCTGTGTTACCAAAAATCAAAACAAATCTTTTTTATTTTTTATTATTATTATTATTTTTGA
GACAGAGTCTCGCTCTGTCGCCCAGTGTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAACTCCGCCTCCCAGGTTCAAGCGATTCTC
CCACCTCAGCCTCCTGAGTTGGGTCCTACAGGCGCACACGACCACGCCCAGCTAATTTTTTGTATTTTTAGTAGAGTTGGGGTTTCACCA
TGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCACTCACCTCAGCCTCCCAAAATCCTGGGGTTACAGATGTGAGCTACCACT
CACGGCCCAAATCTTCTTGATCATATGTTTAAATATATTTTTTAATATTTGGAGCATGAGTTGTCACTTCTTGTTTGCCTTTTTTATAAG
GAAATGTTGGAGAGTTACATCATTGCTAATGTAGAAATGTTAAGTGGAAAAATATACAGTTTGGTAAAATAAACTAGATTCTACATTTAT
TTGTGGGTTTTTTTCCCCTCCTTTCTTTCCACAGCACTTTTGATATCAAGCAAGTGGCTTCCTTTTTGAGATATTAAAAAAAAAAAGAAA
AGGAAAAAAGTAAATGAAGCCCAACTACCTAACCCTTTCTTATTTGTATTTGTTTTAGTATTGTGAAGTTGTGTTAAATAGTACTAGCTA
GAAATACAAATTTCTGGTTATCATTTCTCTTCCCTGTGGCACTTGACATTTTAATTGTCTTAAAGTTTTTGAAGTACATCTTCTGGCCCC
TTGAGTACTGCCAGAGGCAAAAGATGTTTGTTTCTTATTCATTCCACTTTTGTCTCCTGGGATCCCTTCTGTAGCCTAAAGTATGGCTGG
GAAATGGACTTGAGAAGATTGGCTTGAATTAGATCATAATCATGTGTGATCCCATCATGAATTCATTGGAATTTGTGTTGCATGTAAGGC
AATCTTTCCTGTTGTAAATCTTCCTTTTTTAATGTACATATATTTTGAAAAATATGAATAAACATGAAATTTTAAAAGCTGCTGAACCGT

>86777_86777_1_SSH2-HP1BP3_SSH2_chr17_27982578_ENST00000269033_HP1BP3_chr1_21100103_ENST00000312239_length(amino acids)=769AA_BP=333
MALVTVQRSPTPSTTSSPCASEADSGEEECRSQPRSISESFLTVKGAALFLPRGNGSSTPRISHRRNKHAGDLQQHLQAMFILLRPEDNI
RLAVRLESTYQNRTRYMVVVSTNGRQDTEESIVLGMDFSSNDSSTCTMGLVLPLWSDTLIHLDGDGGFSVSTDNRVHIFKPVSVQAMWSA
LQSLHKACEVARAHNYYPGSLFLTWVSYYESHINSDQSSVNEWNAMQDVQSHRPDSPALFTDIPTERERTERLIKTKLREIMMQKDLENI
TSKEIRTELEMQMVCNLREFKEFIDNEMIVILGQMDSPTQIFEHVFLGSEWNASNLEDLQNRGEKDQSKEKEKKVKKTIPSWATLSASQL
ARAQKQTPMASSPRPKMDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLELERRGYLLKQALKRELNRGVIKQVKGKGASGSFVVVQKS
RKTPQKSRNRKNRSSAVDPEPQVKLEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIRPQLLKNALQRAVERGQLEQITGKGASG
TFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPGTNSNYQMHLLKKTLQKCEKNGWMEQISGKGFSGTFQLCFP
YYPSPGVLFPKKEPDDSRDEDEDEDESSEEDSEDEEPPPKRRLQKKTPAKSPGKAASVKQRGSKPAPKVSAAQRGKARPLPKKAPPKAKT

--------------------------------------------------------------
>86777_86777_2_SSH2-HP1BP3_SSH2_chr17_27982578_ENST00000540801_HP1BP3_chr1_21100103_ENST00000312239_length(transcript)=4620nt_BP=1172nt
CCGCACCCCTTTCCCCATCCCGGCTCCGTCACCCTCCCGTCCCCCACACTCAGGACAAGAATGCCCTGCCCGGAACAACCCAGCAGCGCC
TAGATGGCTTTGGTCACGGTCCAGCGGTCACCTACCCCCAGCACCACCTCCAGCCCCTGCGCCTCGAGCTCTCATTTGGAAGACAGTGAA
TCAGCAGCATTACTTTGCTGTGAATGTGAAGAATCAGAAATCTTTACTGATTCCAATGAGGCAGACAGTGGGGAGGAAGAATGCCGGTCA
CAGCCCAGGAGCATCAGCGAGAGCTTTCTAACTGTCAAAGGTGCTGCCCTTTTTCTACCACGGGGAAATGGCTCATCCACACCAAGAATC
AGCCACAGACGGAACAAGCATGCAGGCGATCTCCAACAGCATCTCCAAGCAATGTTCATTTTACTCCGCCCAGAAGACAACATCAGGCTG
GCTGTAAGACTGGAAAGTACTTACCAGAATCGAACACGCTATATGGTAGTGGTTTCAACTAATGGTAGACAAGACACTGAAGAAAGCATC
GTCCTAGGAATGGATTTCTCCTCTAATGACAGTAGCACTTGTACCATGGGCTTAGTTTTGCCTCTCTGGAGCGACACGCTAATTCATTTG
GATGGTGATGGTGGGTTCAGTGTATCGACGGATAACAGAGTTCACATATTCAAACCTGTATCTGTGCAGGCAATGTGGTCTGCACTACAG
AGCTTACACAAGGCTTGTGAAGTCGCCAGAGCGCATAACTACTACCCAGGCAGCCTATTTCTCACTTGGGTGAGTTATTATGAGAGCCAT
ATCAACTCAGATCAATCCTCAGTCAATGAATGGAATGCAATGCAAGATGTACAGTCCCACCGGCCCGACTCTCCAGCTCTCTTCACCGAC
ATACCTACTGAACGTGAACGAACAGAAAGGCTAATTAAAACCAAATTAAGGGAGATCATGATGCAGAAGGATTTGGAGAATATTACATCC
AAAGAGATAAGAACAGAGTTGGAAATGCAAATGGTGTGCAACTTGCGGGAATTCAAGGAATTTATAGACAATGAAATGATAGTGATCCTT
GGTCAAATGGATAGCCCTACACAGATATTTGAGCATGTGTTCCTGGGCTCAGAATGGAATGCCTCCAACTTAGAGGACTTACAGAACCGA
GGTGAGAAAGATCAGTCTAAAGAAAAGGAGAAGAAAGTGAAAAAAACAATTCCTTCCTGGGCTACCCTTTCTGCCAGCCAGCTAGCCAGG
GCCCAGAAACAAACACCGATGGCTTCTTCCCCACGTCCCAAGATGGATGCAATCTTAACTGAGGCCATTAAGGCATGCTTCCAGAAGAGT
GGTGCATCAGTGGTTGCTATTCGAAAATACATCATCCATAAGTATCCTTCTCTGGAGCTGGAGAGAAGGGGTTATCTCCTTAAACAAGCA
CTGAAAAGAGAATTAAATAGAGGAGTCATCAAACAGGTTAAAGGAAAAGGTGCTTCTGGAAGTTTTGTTGTGGTTCAGAAATCAAGAAAA
ACACCTCAGAAATCCAGAAACAGAAAGAATAGGAGCTCTGCAGTGGATCCAGAACCACAAGTAAAATTGGAGGATGTCCTCCCACTGGCC
TTTACTCGCCTTTGTGAACCTAAAGAAGCTTCCTACAGTCTCATCAGGAAATATGTGTCTCAGTATTATCCTAAGCTTAGAGTGGACATC
AGGCCTCAGCTGTTGAAGAACGCTCTGCAGAGAGCAGTAGAGAGGGGCCAGTTAGAACAGATAACTGGCAAAGGTGCTTCGGGGACATTC
CAGCTGAAGAAATCAGGGGAGAAACCCCTGCTTGGTGGAAGCCTGATGGAATATGCAATCTTGTCTGCCATTGCTGCCATGAATGAGCCG
AAGACCTGCTCTACCACTGCTCTGAAGAAGTATGTCCTAGAGAATCACCCAGGAACCAATTCTAACTATCAAATGCATTTGCTGAAAAAA
ACCCTGCAGAAATGCGAAAAGAATGGGTGGATGGAACAGATCTCTGGGAAAGGGTTCAGTGGCACCTTCCAGCTCTGTTTTCCCTATTAT
CCCAGCCCAGGAGTTCTGTTTCCGAAGAAAGAGCCAGATGATTCTAGAGATGAGGATGAAGATGAAGATGAGTCATCAGAAGAAGACTCT
GAGGATGAAGAGCCGCCACCTAAGAGAAGGTTGCAGAAGAAAACCCCAGCCAAGTCCCCAGGGAAGGCCGCATCTGTGAAGCAGAGAGGG
TCCAAACCTGCACCTAAAGTCTCAGCTGCCCAGCGGGGGAAAGCTAGGCCCTTGCCTAAGAAAGCACCTCCTAAGGCCAAAACGCCTGCC
AAGAAGACCAGACCCTCATCCACAGTCATCAAGAAACCTAGTGGTGGCTCCTCAAAGAAGCCTGCAACCAGTGCAAGAAAGGAAGTAAAA
TTGCCGGGCAAGGGCAAATCCACCATGAAGAAGTCTTTCAGAGTGAAAAAGTAAATTTTATAGGAAAAAAGGGTATCATGATGAAATTCA
AAATCTTATTTTCTAAGGTCAGTGTGCATTTGTTTAGTTTTGATGCTTTTCAAATTACATTATTTTCCTCCCCTATGAACATTGTGGGGA
GGGACTCTAAATAAACCAGTTTAGGCATTTGCTAGCTTTAGGTGCTTTTATTGGTGCCTGCCCTTTTCCTTGTTCATTTTAATTTCTGCA
ATAATCCTGGACTTTCCTAAACTATGTAATGTATACTTGTCCTTTTTCTCTGCCTCCCCCAACCCCCTGTTGTTTTTATGGTCAGCTTTG
CCTTTTTTTTTTCTTCCAATTTTATCTAAACAGTTGCAGAGATTTTTATATTTGTAGAAAGCATCAAGAACGGTATGCCAGTCAGGTCCT
GGAAGTAAAATGGAGGCACAATATAGCACTGACTGAGTTGTAAAGCCTCCTGCCTGGAGACTTCAGTTATAGCTGTAATAATTAATCTTA
TTTATAAAAGCCACTCCACTAACCTTTTCTCTCCAACTGTAAACACAGAGACAGCTTTGGGAATAAGCCAAAAACAGGGTGATCTCATTA
GATTTTGAAGATATATGACTCCTTTGGGCTACATTTCATATTGATCAATTTCTAGGTATTTTTCACTGGCCCAAAGTATTGCATTCCCTT
AACAGCAAGCACAAGTTCTCTATATCACTTGTTTTTTGTTGTTGTTGTTGTTGTCGTCGTTGTTTTGAGACGGAGTCTTGCTCAGGTGCC
CCGGAGTGCAGTGGTGCAATCTCAGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCAATTCTCCTGCTTCAGCCTCCCGAGTAGCTGGG
ATTACAGGTGTGTACCACCACGCCTGGCAATTTTTTTGTATTTTTAGTAGAGATGGGGTTTCGCCGTGTTGGTCAGGCTGGTCTCGAACT
CCTGACCTCAGGTGATCCGCCTGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGAGTGAGCCACTGTGCCTGGCCTATCCCACTTGGTTT
TTGACTGAAGGGGAAGTGTAGAAATATATTGATTTGTGATTTCTGGTGTCACCTGTGTTACCAAAAATCAAAACAAATCTTTTTTATTTT
TTATTATTATTATTATTTTTGAGACAGAGTCTCGCTCTGTCGCCCAGTGTGGAGTGCAGTGGTGTGATCTTGGCTCACTGCAAACTCCGC
CTCCCAGGTTCAAGCGATTCTCCCACCTCAGCCTCCTGAGTTGGGTCCTACAGGCGCACACGACCACGCCCAGCTAATTTTTTGTATTTT
TAGTAGAGTTGGGGTTTCACCATGTTAGCCAGGATGGTCTCGATCTCCTGACCTCGTGATCCACTCACCTCAGCCTCCCAAAATCCTGGG
GTTACAGATGTGAGCTACCACTCACGGCCCAAATCTTCTTGATCATATGTTTAAATATATTTTTTAATATTTGGAGCATGAGTTGTCACT
TCTTGTTTGCCTTTTTTATAAGGAAATGTTGGAGAGTTACATCATTGCTAATGTAGAAATGTTAAGTGGAAAAATATACAGTTTGGTAAA
ATAAACTAGATTCTACATTTATTTGTGGGTTTTTTTCCCCTCCTTTCTTTCCACAGCACTTTTGATATCAAGCAAGTGGCTTCCTTTTTG
AGATATTAAAAAAAAAAAGAAAAGGAAAAAAGTAAATGAAGCCCAACTACCTAACCCTTTCTTATTTGTATTTGTTTTAGTATTGTGAAG
TTGTGTTAAATAGTACTAGCTAGAAATACAAATTTCTGGTTATCATTTCTCTTCCCTGTGGCACTTGACATTTTAATTGTCTTAAAGTTT
TTGAAGTACATCTTCTGGCCCCTTGAGTACTGCCAGAGGCAAAAGATGTTTGTTTCTTATTCATTCCACTTTTGTCTCCTGGGATCCCTT
CTGTAGCCTAAAGTATGGCTGGGAAATGGACTTGAGAAGATTGGCTTGAATTAGATCATAATCATGTGTGATCCCATCATGAATTCATTG
GAATTTGTGTTGCATGTAAGGCAATCTTTCCTGTTGTAAATCTTCCTTTTTTAATGTACATATATTTTGAAAAATATGAATAAACATGAA

>86777_86777_2_SSH2-HP1BP3_SSH2_chr17_27982578_ENST00000540801_HP1BP3_chr1_21100103_ENST00000312239_length(amino acids)=796AA_BP=360
MALVTVQRSPTPSTTSSPCASSSHLEDSESAALLCCECEESEIFTDSNEADSGEEECRSQPRSISESFLTVKGAALFLPRGNGSSTPRIS
HRRNKHAGDLQQHLQAMFILLRPEDNIRLAVRLESTYQNRTRYMVVVSTNGRQDTEESIVLGMDFSSNDSSTCTMGLVLPLWSDTLIHLD
GDGGFSVSTDNRVHIFKPVSVQAMWSALQSLHKACEVARAHNYYPGSLFLTWVSYYESHINSDQSSVNEWNAMQDVQSHRPDSPALFTDI
PTERERTERLIKTKLREIMMQKDLENITSKEIRTELEMQMVCNLREFKEFIDNEMIVILGQMDSPTQIFEHVFLGSEWNASNLEDLQNRG
EKDQSKEKEKKVKKTIPSWATLSASQLARAQKQTPMASSPRPKMDAILTEAIKACFQKSGASVVAIRKYIIHKYPSLELERRGYLLKQAL
KRELNRGVIKQVKGKGASGSFVVVQKSRKTPQKSRNRKNRSSAVDPEPQVKLEDVLPLAFTRLCEPKEASYSLIRKYVSQYYPKLRVDIR
PQLLKNALQRAVERGQLEQITGKGASGTFQLKKSGEKPLLGGSLMEYAILSAIAAMNEPKTCSTTALKKYVLENHPGTNSNYQMHLLKKT
LQKCEKNGWMEQISGKGFSGTFQLCFPYYPSPGVLFPKKEPDDSRDEDEDEDESSEEDSEDEEPPPKRRLQKKTPAKSPGKAASVKQRGS

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Top

Fusion Gene PPI Analysis for SSH2-HP1BP3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SSH2-HP1BP3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for SSH2-HP1BP3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source