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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SSR3-TRPC1 (FusionGDB2 ID:86848)

Fusion Gene Summary for SSR3-TRPC1

check button Fusion gene summary
Fusion gene informationFusion gene name: SSR3-TRPC1
Fusion gene ID: 86848
HgeneTgene
Gene symbol

SSR3

TRPC1

Gene ID

6747

7220

Gene namesignal sequence receptor subunit 3transient receptor potential cation channel subfamily C member 1
SynonymsTRAPGHTRP-1|TRP1
Cytomap

3q25.31

3q23

Type of geneprotein-codingprotein-coding
Descriptiontranslocon-associated protein subunit gammaSSR gammaTRAP-complex gamma subunitTRAP-gammasignal sequence receptor subunit gammasignal sequence receptor, gamma (translocon-associated protein gamma)translocon-associated protein gamma subunitshort transient receptor potential channel 1TRP-1capacitative calcium channel protein Trp1transient receptor potential canonical 1transient receptor protein 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000265044, ENST00000467789, 
ENST00000476217, ENST00000463503, 
ENST00000478842, ENST00000496050, 
ENST00000273482, ENST00000476941, 
Fusion gene scores* DoF score7 X 7 X 4=1962 X 2 X 2=8
# samples 72
** MAII scorelog2(7/196*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: SSR3 [Title/Abstract] AND TRPC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSSR3(156272746)-TRPC1(142521011), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTRPC1

GO:0042438

melanin biosynthetic process

8126111

TgeneTRPC1

GO:0051281

positive regulation of release of sequestered calcium ion into cytosol

19052258

TgeneTRPC1

GO:0051480

regulation of cytosolic calcium ion concentration

19052258

TgeneTRPC1

GO:0051592

response to calcium ion

14505576|19052258


check buttonFusion gene breakpoints across SSR3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TRPC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A06U-01ASSR3chr3

156272746

-TRPC1chr3

142521011

+


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Fusion Gene ORF analysis for SSR3-TRPC1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000265044ENST00000273482SSR3chr3

156272746

-TRPC1chr3

142521011

+
In-frameENST00000265044ENST00000476941SSR3chr3

156272746

-TRPC1chr3

142521011

+
In-frameENST00000467789ENST00000273482SSR3chr3

156272746

-TRPC1chr3

142521011

+
In-frameENST00000467789ENST00000476941SSR3chr3

156272746

-TRPC1chr3

142521011

+
In-frameENST00000476217ENST00000273482SSR3chr3

156272746

-TRPC1chr3

142521011

+
In-frameENST00000476217ENST00000476941SSR3chr3

156272746

-TRPC1chr3

142521011

+
intron-3CDSENST00000463503ENST00000273482SSR3chr3

156272746

-TRPC1chr3

142521011

+
intron-3CDSENST00000463503ENST00000476941SSR3chr3

156272746

-TRPC1chr3

142521011

+
intron-3CDSENST00000478842ENST00000273482SSR3chr3

156272746

-TRPC1chr3

142521011

+
intron-3CDSENST00000478842ENST00000476941SSR3chr3

156272746

-TRPC1chr3

142521011

+
intron-3CDSENST00000496050ENST00000273482SSR3chr3

156272746

-TRPC1chr3

142521011

+
intron-3CDSENST00000496050ENST00000476941SSR3chr3

156272746

-TRPC1chr3

142521011

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000265044SSR3chr3156272746-ENST00000476941TRPC1chr3142521011+1222228721028318
ENST00000265044SSR3chr3156272746-ENST00000273482TRPC1chr3142521011+2682228721028318
ENST00000467789SSR3chr3156272746-ENST00000476941TRPC1chr3142521011+118719337993318
ENST00000467789SSR3chr3156272746-ENST00000273482TRPC1chr3142521011+264719337993318
ENST00000476217SSR3chr3156272746-ENST00000476941TRPC1chr3142521011+116316913969318
ENST00000476217SSR3chr3156272746-ENST00000273482TRPC1chr3142521011+262316913969318

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000265044ENST00000476941SSR3chr3156272746-TRPC1chr3142521011+0.0028528650.99714714
ENST00000265044ENST00000273482SSR3chr3156272746-TRPC1chr3142521011+0.0011488850.99885106
ENST00000467789ENST00000476941SSR3chr3156272746-TRPC1chr3142521011+0.0028988950.9971011
ENST00000467789ENST00000273482SSR3chr3156272746-TRPC1chr3142521011+0.0012158330.9987841
ENST00000476217ENST00000476941SSR3chr3156272746-TRPC1chr3142521011+0.0031583150.99684167
ENST00000476217ENST00000273482SSR3chr3156272746-TRPC1chr3142521011+0.0013085570.9986915

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Fusion Genomic Features for SSR3-TRPC1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SSR3chr3156272745-TRPC1chr3142521010+2.30E-050.999977
SSR3chr3156272745-TRPC1chr3142521010+2.30E-050.999977

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SSR3-TRPC1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:156272746/chr3:142521011)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSSR3chr3:156272746chr3:142521011ENST00000265044-151_2744186.0Topological domainLumenal
TgeneTRPC1chr3:156272746chr3:142521011ENST00000273482712561_586493760.0Topological domainCytoplasmic
TgeneTRPC1chr3:156272746chr3:142521011ENST00000273482712608_616493760.0Topological domainExtracellular
TgeneTRPC1chr3:156272746chr3:142521011ENST00000476941813561_586527794.0Topological domainCytoplasmic
TgeneTRPC1chr3:156272746chr3:142521011ENST00000476941813608_616527794.0Topological domainExtracellular
TgeneTRPC1chr3:156272746chr3:142521011ENST00000273482712540_560493760.0TransmembraneHelical
TgeneTRPC1chr3:156272746chr3:142521011ENST00000273482712587_607493760.0TransmembraneHelical
TgeneTRPC1chr3:156272746chr3:142521011ENST00000273482712617_637493760.0TransmembraneHelical
TgeneTRPC1chr3:156272746chr3:142521011ENST00000476941813540_560527794.0TransmembraneHelical
TgeneTRPC1chr3:156272746chr3:142521011ENST00000476941813587_607527794.0TransmembraneHelical
TgeneTRPC1chr3:156272746chr3:142521011ENST00000476941813617_637527794.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSSR3chr3:156272746chr3:142521011ENST00000265044-15158_16344186.0Topological domainCytoplasmic
HgeneSSR3chr3:156272746chr3:142521011ENST00000265044-1549_5444186.0Topological domainCytoplasmic
HgeneSSR3chr3:156272746chr3:142521011ENST00000265044-1577_13544186.0Topological domainLumenal
HgeneSSR3chr3:156272746chr3:142521011ENST00000265044-15136_15744186.0TransmembraneHelical
HgeneSSR3chr3:156272746chr3:142521011ENST00000265044-15164_18444186.0TransmembraneHelical
HgeneSSR3chr3:156272746chr3:142521011ENST00000265044-1528_4844186.0TransmembraneHelical
HgeneSSR3chr3:156272746chr3:142521011ENST00000265044-1555_7644186.0TransmembraneHelical
TgeneTRPC1chr3:156272746chr3:142521011ENST00000273482712112_138493760.0RepeatNote=ANK 3
TgeneTRPC1chr3:156272746chr3:142521011ENST00000273482712158_187493760.0RepeatNote=ANK 4
TgeneTRPC1chr3:156272746chr3:142521011ENST0000027348271246_75493760.0RepeatNote=ANK 1
TgeneTRPC1chr3:156272746chr3:142521011ENST0000027348271283_111493760.0RepeatNote=ANK 2
TgeneTRPC1chr3:156272746chr3:142521011ENST00000476941813112_138527794.0RepeatNote=ANK 3
TgeneTRPC1chr3:156272746chr3:142521011ENST00000476941813158_187527794.0RepeatNote=ANK 4
TgeneTRPC1chr3:156272746chr3:142521011ENST0000047694181346_75527794.0RepeatNote=ANK 1
TgeneTRPC1chr3:156272746chr3:142521011ENST0000047694181383_111527794.0RepeatNote=ANK 2
TgeneTRPC1chr3:156272746chr3:142521011ENST000002734827121_386493760.0Topological domainCytoplasmic
TgeneTRPC1chr3:156272746chr3:142521011ENST00000273482712408_415493760.0Topological domainExtracellular
TgeneTRPC1chr3:156272746chr3:142521011ENST00000273482712437_457493760.0Topological domainCytoplasmic
TgeneTRPC1chr3:156272746chr3:142521011ENST00000273482712476_539493760.0Topological domainExtracellular
TgeneTRPC1chr3:156272746chr3:142521011ENST000004769418131_386527794.0Topological domainCytoplasmic
TgeneTRPC1chr3:156272746chr3:142521011ENST00000476941813408_415527794.0Topological domainExtracellular
TgeneTRPC1chr3:156272746chr3:142521011ENST00000476941813437_457527794.0Topological domainCytoplasmic
TgeneTRPC1chr3:156272746chr3:142521011ENST00000476941813476_539527794.0Topological domainExtracellular
TgeneTRPC1chr3:156272746chr3:142521011ENST00000273482712387_407493760.0TransmembraneHelical
TgeneTRPC1chr3:156272746chr3:142521011ENST00000273482712416_436493760.0TransmembraneHelical
TgeneTRPC1chr3:156272746chr3:142521011ENST00000273482712458_475493760.0TransmembraneHelical
TgeneTRPC1chr3:156272746chr3:142521011ENST00000476941813387_407527794.0TransmembraneHelical
TgeneTRPC1chr3:156272746chr3:142521011ENST00000476941813416_436527794.0TransmembraneHelical
TgeneTRPC1chr3:156272746chr3:142521011ENST00000476941813458_475527794.0TransmembraneHelical


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Fusion Gene Sequence for SSR3-TRPC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>86848_86848_1_SSR3-TRPC1_SSR3_chr3_156272746_ENST00000265044_TRPC1_chr3_142521011_ENST00000273482_length(transcript)=2682nt_BP=228nt
GTTAGCGGATACGGCGGCCGCAGGGGCGGAGTCAAGGGCCTTTGCCCGCCTTGGCGGCCGGCTCTACGTTCCCTGTTCTCGCCTGCAGCT
CCGCCATGGCTCCTAAAGGCAGCTCCAAACAGCAGTCTGAGGAGGACCTGCTCCTGCAGGATTTCAGCCGCAATCTCTCGGCCAAGTCCT
CCGCGCTCTTCTTCGGAAACGCGTTCATCGTGTCTGCCATCCCCATCTATTTCAATGGGACAGATGTTACAAGATTTTGGAAAATTTCTT
GGGATGTTTCTTCTTGTTTTGTTTTCTTTCACAATTGGACTGACACAACTGTATGATAAAGGATATACTTCAAAGGAGCAGAAGGACTGT
GTAGGCATCTTCTGTGAACAGCAAAGCAATGATACCTTCCATTCGTTCATTGGCACCTGCTTTGCTTTGTTCTGGTATATTTTCTCCTTA
GCGCATGTGGCAATCTTTGTCACAAGATTTAGCTATGGAGAAGAACTGCAGTCCTTTGTGGGAGCTGTCATTGTTGGTACATACAATGTC
GTGGTTGTGATTGTGCTTACCAAACTGCTGGTGGCAATGCTTCATAAAAGCTTTCAGTTGATAGCAAATCATGAAGACAAAGAATGGAAG
TTTGCTCGAGCAAAATTATGGCTTAGCTACTTTGATGACAAATGTACGTTACCTCCACCTTTCAACATCATTCCCTCACCAAAGACTATC
TGCTATATGATTAGTAGCCTCAGTAAGTGGATTTGCTCTCATACATCAAAAGGCAAGGTCAAACGGCAAAACAGTTTAAAGGAATGGAGG
AATTTGAAACAGAAGAGAGATGAAAACTATCAAAAAGTGATGTGCTGCCTAGTGCATCGTTACTTGACTTCCATGAGACAGAAGATGCAA
AGTACAGATCAGGCAACTGTGGAAAATCTAAACGAACTGCGCCAAGATCTGTCAAAATTCCGAAATGAAATAAGGGATTTACTTGGCTTT
CGGACTTCTAAATATGCTATGTTTTATCCAAGAAATTAACCATTTTCTAAATCATGGAGCGAATAATTTTCAATAACAGATCCAAAAGAC
TATATTGCATAACTTGCAATGAAATTAATGAGATATATATTGAAATAAAGAATTATGTAAAAGCCATTCTTTAAAATATTTATAGCATAA
ATATATGTTATGTAAAGTGTGTATATAGAATTAGTTTTTTAAACCTTCTGTTAGTGGCTTTTTGCAGAAGCAAAACAGATTAAGTAGATA
GATTTTGTTAGCATGCTGCTTGGTTTTCTTACTTAGTGCTTTAAAATGTTTTTTTTTATGTTTAAGAGGGGCAGTTATAAATGGACACAT
TGCCCAGAATGTTTTGTAAAATGAAGACCAGCAAATGTAGGCTGATCTCCTTCACAGGATACACTTGAAATATAGAAGTTATGTTTTAAA
TATCTCTGTTTTAGGAGTTCACATATAGTTCAGCATTTATTGTTTAGGAGTATAATTTTATTTTATCTAAAATAATAGTCTATTTTTTCT
TTTGTATTTTGTTATAATCTTAAGCAACAAAGAAAAAACCCTAATATTTGAATCTATTTATGTCTTTCAATTTAAATTCACTTCAGTTTT
TGTTATTGTAATATATTTACTTTTACATGGTTATAATCACTTTATATTTTTAATGTTTTTTTCACTTAATATTTTATATATACATTTCCA
TGTATTGATGTAGTTAGTCCACATTTAAATTTTTATAGAATTATATAGTTTTTGAAAAATACAGTCAGTAGATGTTTTATTTTTTAGCTA
TTCAGTTATGTTTATAAGTTTGCATAGCTACTTCTCGACATTTGGTTTGTTTTAATTTTTTTGTATCATAATAGTCCTATTTTTTTTTCA
AGTTGGAGTGAATGTTTTTAGTTTTAAGATAGATAGGAGACACTTTTTTATCACATGTAGTCACAACCTGTTTTGTTTTTGTAAAACATA
GGAAGTCTCTTTAATGCAATGATTTGTTTTATATTTGGACTAAGGTTCTTGAGCTTATCTCCCAAGGTACTTTCCATAATTTAACACAGC
TTCTATAAAAGTGACTTCATGCTTACTTGTGGATCATTCTTGCTGCTTAAGATGAAAAGCATTGGTTTTTTAAAATTAGAGAATAAAATA
TGTATTTAAATTTTTGGTGTGTTCACATAAAGGGATGTAGCTAAAATGTTTTCATAGGCTATTATATATTCTCGCAGCATTTCCAGTTAA
GAGGATATTAGGTATATAATTCTCTTCTTAACCGAATGTCAGATGGTCTTACGCCACAGGGTGCAGGTAACCCTTGGTCTGTAAGCACCA
CCGATCCAGGGATCATTGTCTAAATAGGTTACTATTGTTTGTTTCATCTTGCTTTTGCATTTTTATTTTTTAATTTCCAAATTTTAAGTG
TTCCCTCTTTGGGGCAAATTCTTATAAAAATGTTTATTGTAAAGTTATATATTTTGTCTACGATGGGATTATGCACTTCCCAATTGGGAT
TTTACATCTGGATTTTTAGTCATTCTAAAAAACACCTAATTATTAAAACATTTATAGAGTGCCTACTGTATGCATGAGTTGAGTTGCTTC

>86848_86848_1_SSR3-TRPC1_SSR3_chr3_156272746_ENST00000265044_TRPC1_chr3_142521011_ENST00000273482_length(amino acids)=318AA_BP=50
MFSPAAPPWLLKAAPNSSLRRTCSCRISAAISRPSPPRSSSETRSSCLPSPSISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTS
KEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANH
EDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTS

--------------------------------------------------------------
>86848_86848_2_SSR3-TRPC1_SSR3_chr3_156272746_ENST00000265044_TRPC1_chr3_142521011_ENST00000476941_length(transcript)=1222nt_BP=228nt
GTTAGCGGATACGGCGGCCGCAGGGGCGGAGTCAAGGGCCTTTGCCCGCCTTGGCGGCCGGCTCTACGTTCCCTGTTCTCGCCTGCAGCT
CCGCCATGGCTCCTAAAGGCAGCTCCAAACAGCAGTCTGAGGAGGACCTGCTCCTGCAGGATTTCAGCCGCAATCTCTCGGCCAAGTCCT
CCGCGCTCTTCTTCGGAAACGCGTTCATCGTGTCTGCCATCCCCATCTATTTCAATGGGACAGATGTTACAAGATTTTGGAAAATTTCTT
GGGATGTTTCTTCTTGTTTTGTTTTCTTTCACAATTGGACTGACACAACTGTATGATAAAGGATATACTTCAAAGGAGCAGAAGGACTGT
GTAGGCATCTTCTGTGAACAGCAAAGCAATGATACCTTCCATTCGTTCATTGGCACCTGCTTTGCTTTGTTCTGGTATATTTTCTCCTTA
GCGCATGTGGCAATCTTTGTCACAAGATTTAGCTATGGAGAAGAACTGCAGTCCTTTGTGGGAGCTGTCATTGTTGGTACATACAATGTC
GTGGTTGTGATTGTGCTTACCAAACTGCTGGTGGCAATGCTTCATAAAAGCTTTCAGTTGATAGCAAATCATGAAGACAAAGAATGGAAG
TTTGCTCGAGCAAAATTATGGCTTAGCTACTTTGATGACAAATGTACGTTACCTCCACCTTTCAACATCATTCCCTCACCAAAGACTATC
TGCTATATGATTAGTAGCCTCAGTAAGTGGATTTGCTCTCATACATCAAAAGGCAAGGTCAAACGGCAAAACAGTTTAAAGGAATGGAGG
AATTTGAAACAGAAGAGAGATGAAAACTATCAAAAAGTGATGTGCTGCCTAGTGCATCGTTACTTGACTTCCATGAGACAGAAGATGCAA
AGTACAGATCAGGCAACTGTGGAAAATCTAAACGAACTGCGCCAAGATCTGTCAAAATTCCGAAATGAAATAAGGGATTTACTTGGCTTT
CGGACTTCTAAATATGCTATGTTTTATCCAAGAAATTAACCATTTTCTAAATCATGGAGCGAATAATTTTCAATAACAGATCCAAAAGAC
TATATTGCATAACTTGCAATGAAATTAATGAGATATATATTGAAATAAAGAATTATGTAAAAGCCATTCTTTAAAATATTTATAGCATAA

>86848_86848_2_SSR3-TRPC1_SSR3_chr3_156272746_ENST00000265044_TRPC1_chr3_142521011_ENST00000476941_length(amino acids)=318AA_BP=50
MFSPAAPPWLLKAAPNSSLRRTCSCRISAAISRPSPPRSSSETRSSCLPSPSISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTS
KEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANH
EDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTS

--------------------------------------------------------------
>86848_86848_3_SSR3-TRPC1_SSR3_chr3_156272746_ENST00000467789_TRPC1_chr3_142521011_ENST00000273482_length(transcript)=2647nt_BP=193nt
GGGCCTTTGCCCGCCTTGGCGGCCGGCTCTACGTTCCCTGTTCTCGCCTGCAGCTCCGCCATGGCTCCTAAAGGCAGCTCCAAACAGCAG
TCTGAGGAGGACCTGCTCCTGCAGGATTTCAGCCGCAATCTCTCGGCCAAGTCCTCCGCGCTCTTCTTCGGAAACGCGTTCATCGTGTCT
GCCATCCCCATCTATTTCAATGGGACAGATGTTACAAGATTTTGGAAAATTTCTTGGGATGTTTCTTCTTGTTTTGTTTTCTTTCACAAT
TGGACTGACACAACTGTATGATAAAGGATATACTTCAAAGGAGCAGAAGGACTGTGTAGGCATCTTCTGTGAACAGCAAAGCAATGATAC
CTTCCATTCGTTCATTGGCACCTGCTTTGCTTTGTTCTGGTATATTTTCTCCTTAGCGCATGTGGCAATCTTTGTCACAAGATTTAGCTA
TGGAGAAGAACTGCAGTCCTTTGTGGGAGCTGTCATTGTTGGTACATACAATGTCGTGGTTGTGATTGTGCTTACCAAACTGCTGGTGGC
AATGCTTCATAAAAGCTTTCAGTTGATAGCAAATCATGAAGACAAAGAATGGAAGTTTGCTCGAGCAAAATTATGGCTTAGCTACTTTGA
TGACAAATGTACGTTACCTCCACCTTTCAACATCATTCCCTCACCAAAGACTATCTGCTATATGATTAGTAGCCTCAGTAAGTGGATTTG
CTCTCATACATCAAAAGGCAAGGTCAAACGGCAAAACAGTTTAAAGGAATGGAGGAATTTGAAACAGAAGAGAGATGAAAACTATCAAAA
AGTGATGTGCTGCCTAGTGCATCGTTACTTGACTTCCATGAGACAGAAGATGCAAAGTACAGATCAGGCAACTGTGGAAAATCTAAACGA
ACTGCGCCAAGATCTGTCAAAATTCCGAAATGAAATAAGGGATTTACTTGGCTTTCGGACTTCTAAATATGCTATGTTTTATCCAAGAAA
TTAACCATTTTCTAAATCATGGAGCGAATAATTTTCAATAACAGATCCAAAAGACTATATTGCATAACTTGCAATGAAATTAATGAGATA
TATATTGAAATAAAGAATTATGTAAAAGCCATTCTTTAAAATATTTATAGCATAAATATATGTTATGTAAAGTGTGTATATAGAATTAGT
TTTTTAAACCTTCTGTTAGTGGCTTTTTGCAGAAGCAAAACAGATTAAGTAGATAGATTTTGTTAGCATGCTGCTTGGTTTTCTTACTTA
GTGCTTTAAAATGTTTTTTTTTATGTTTAAGAGGGGCAGTTATAAATGGACACATTGCCCAGAATGTTTTGTAAAATGAAGACCAGCAAA
TGTAGGCTGATCTCCTTCACAGGATACACTTGAAATATAGAAGTTATGTTTTAAATATCTCTGTTTTAGGAGTTCACATATAGTTCAGCA
TTTATTGTTTAGGAGTATAATTTTATTTTATCTAAAATAATAGTCTATTTTTTCTTTTGTATTTTGTTATAATCTTAAGCAACAAAGAAA
AAACCCTAATATTTGAATCTATTTATGTCTTTCAATTTAAATTCACTTCAGTTTTTGTTATTGTAATATATTTACTTTTACATGGTTATA
ATCACTTTATATTTTTAATGTTTTTTTCACTTAATATTTTATATATACATTTCCATGTATTGATGTAGTTAGTCCACATTTAAATTTTTA
TAGAATTATATAGTTTTTGAAAAATACAGTCAGTAGATGTTTTATTTTTTAGCTATTCAGTTATGTTTATAAGTTTGCATAGCTACTTCT
CGACATTTGGTTTGTTTTAATTTTTTTGTATCATAATAGTCCTATTTTTTTTTCAAGTTGGAGTGAATGTTTTTAGTTTTAAGATAGATA
GGAGACACTTTTTTATCACATGTAGTCACAACCTGTTTTGTTTTTGTAAAACATAGGAAGTCTCTTTAATGCAATGATTTGTTTTATATT
TGGACTAAGGTTCTTGAGCTTATCTCCCAAGGTACTTTCCATAATTTAACACAGCTTCTATAAAAGTGACTTCATGCTTACTTGTGGATC
ATTCTTGCTGCTTAAGATGAAAAGCATTGGTTTTTTAAAATTAGAGAATAAAATATGTATTTAAATTTTTGGTGTGTTCACATAAAGGGA
TGTAGCTAAAATGTTTTCATAGGCTATTATATATTCTCGCAGCATTTCCAGTTAAGAGGATATTAGGTATATAATTCTCTTCTTAACCGA
ATGTCAGATGGTCTTACGCCACAGGGTGCAGGTAACCCTTGGTCTGTAAGCACCACCGATCCAGGGATCATTGTCTAAATAGGTTACTAT
TGTTTGTTTCATCTTGCTTTTGCATTTTTATTTTTTAATTTCCAAATTTTAAGTGTTCCCTCTTTGGGGCAAATTCTTATAAAAATGTTT
ATTGTAAAGTTATATATTTTGTCTACGATGGGATTATGCACTTCCCAATTGGGATTTTACATCTGGATTTTTAGTCATTCTAAAAAACAC
CTAATTATTAAAACATTTATAGAGTGCCTACTGTATGCATGAGTTGAGTTGCTTCTGAGGTACATTTTGAATGACAGCATATTGTAAGAA

>86848_86848_3_SSR3-TRPC1_SSR3_chr3_156272746_ENST00000467789_TRPC1_chr3_142521011_ENST00000273482_length(amino acids)=318AA_BP=50
MFSPAAPPWLLKAAPNSSLRRTCSCRISAAISRPSPPRSSSETRSSCLPSPSISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTS
KEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANH
EDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTS

--------------------------------------------------------------
>86848_86848_4_SSR3-TRPC1_SSR3_chr3_156272746_ENST00000467789_TRPC1_chr3_142521011_ENST00000476941_length(transcript)=1187nt_BP=193nt
GGGCCTTTGCCCGCCTTGGCGGCCGGCTCTACGTTCCCTGTTCTCGCCTGCAGCTCCGCCATGGCTCCTAAAGGCAGCTCCAAACAGCAG
TCTGAGGAGGACCTGCTCCTGCAGGATTTCAGCCGCAATCTCTCGGCCAAGTCCTCCGCGCTCTTCTTCGGAAACGCGTTCATCGTGTCT
GCCATCCCCATCTATTTCAATGGGACAGATGTTACAAGATTTTGGAAAATTTCTTGGGATGTTTCTTCTTGTTTTGTTTTCTTTCACAAT
TGGACTGACACAACTGTATGATAAAGGATATACTTCAAAGGAGCAGAAGGACTGTGTAGGCATCTTCTGTGAACAGCAAAGCAATGATAC
CTTCCATTCGTTCATTGGCACCTGCTTTGCTTTGTTCTGGTATATTTTCTCCTTAGCGCATGTGGCAATCTTTGTCACAAGATTTAGCTA
TGGAGAAGAACTGCAGTCCTTTGTGGGAGCTGTCATTGTTGGTACATACAATGTCGTGGTTGTGATTGTGCTTACCAAACTGCTGGTGGC
AATGCTTCATAAAAGCTTTCAGTTGATAGCAAATCATGAAGACAAAGAATGGAAGTTTGCTCGAGCAAAATTATGGCTTAGCTACTTTGA
TGACAAATGTACGTTACCTCCACCTTTCAACATCATTCCCTCACCAAAGACTATCTGCTATATGATTAGTAGCCTCAGTAAGTGGATTTG
CTCTCATACATCAAAAGGCAAGGTCAAACGGCAAAACAGTTTAAAGGAATGGAGGAATTTGAAACAGAAGAGAGATGAAAACTATCAAAA
AGTGATGTGCTGCCTAGTGCATCGTTACTTGACTTCCATGAGACAGAAGATGCAAAGTACAGATCAGGCAACTGTGGAAAATCTAAACGA
ACTGCGCCAAGATCTGTCAAAATTCCGAAATGAAATAAGGGATTTACTTGGCTTTCGGACTTCTAAATATGCTATGTTTTATCCAAGAAA
TTAACCATTTTCTAAATCATGGAGCGAATAATTTTCAATAACAGATCCAAAAGACTATATTGCATAACTTGCAATGAAATTAATGAGATA
TATATTGAAATAAAGAATTATGTAAAAGCCATTCTTTAAAATATTTATAGCATAAATATATGTTATGTAAAGTGTGTATATAGAATTAGT

>86848_86848_4_SSR3-TRPC1_SSR3_chr3_156272746_ENST00000467789_TRPC1_chr3_142521011_ENST00000476941_length(amino acids)=318AA_BP=50
MFSPAAPPWLLKAAPNSSLRRTCSCRISAAISRPSPPRSSSETRSSCLPSPSISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTS
KEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANH
EDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTS

--------------------------------------------------------------
>86848_86848_5_SSR3-TRPC1_SSR3_chr3_156272746_ENST00000476217_TRPC1_chr3_142521011_ENST00000273482_length(transcript)=2623nt_BP=169nt
GGCTCTACGTTCCCTGTTCTCGCCTGCAGCTCCGCCATGGCTCCTAAAGGCAGCTCCAAACAGCAGTCTGAGGAGGACCTGCTCCTGCAG
GATTTCAGCCGCAATCTCTCGGCCAAGTCCTCCGCGCTCTTCTTCGGAAACGCGTTCATCGTGTCTGCCATCCCCATCTATTTCAATGGG
ACAGATGTTACAAGATTTTGGAAAATTTCTTGGGATGTTTCTTCTTGTTTTGTTTTCTTTCACAATTGGACTGACACAACTGTATGATAA
AGGATATACTTCAAAGGAGCAGAAGGACTGTGTAGGCATCTTCTGTGAACAGCAAAGCAATGATACCTTCCATTCGTTCATTGGCACCTG
CTTTGCTTTGTTCTGGTATATTTTCTCCTTAGCGCATGTGGCAATCTTTGTCACAAGATTTAGCTATGGAGAAGAACTGCAGTCCTTTGT
GGGAGCTGTCATTGTTGGTACATACAATGTCGTGGTTGTGATTGTGCTTACCAAACTGCTGGTGGCAATGCTTCATAAAAGCTTTCAGTT
GATAGCAAATCATGAAGACAAAGAATGGAAGTTTGCTCGAGCAAAATTATGGCTTAGCTACTTTGATGACAAATGTACGTTACCTCCACC
TTTCAACATCATTCCCTCACCAAAGACTATCTGCTATATGATTAGTAGCCTCAGTAAGTGGATTTGCTCTCATACATCAAAAGGCAAGGT
CAAACGGCAAAACAGTTTAAAGGAATGGAGGAATTTGAAACAGAAGAGAGATGAAAACTATCAAAAAGTGATGTGCTGCCTAGTGCATCG
TTACTTGACTTCCATGAGACAGAAGATGCAAAGTACAGATCAGGCAACTGTGGAAAATCTAAACGAACTGCGCCAAGATCTGTCAAAATT
CCGAAATGAAATAAGGGATTTACTTGGCTTTCGGACTTCTAAATATGCTATGTTTTATCCAAGAAATTAACCATTTTCTAAATCATGGAG
CGAATAATTTTCAATAACAGATCCAAAAGACTATATTGCATAACTTGCAATGAAATTAATGAGATATATATTGAAATAAAGAATTATGTA
AAAGCCATTCTTTAAAATATTTATAGCATAAATATATGTTATGTAAAGTGTGTATATAGAATTAGTTTTTTAAACCTTCTGTTAGTGGCT
TTTTGCAGAAGCAAAACAGATTAAGTAGATAGATTTTGTTAGCATGCTGCTTGGTTTTCTTACTTAGTGCTTTAAAATGTTTTTTTTTAT
GTTTAAGAGGGGCAGTTATAAATGGACACATTGCCCAGAATGTTTTGTAAAATGAAGACCAGCAAATGTAGGCTGATCTCCTTCACAGGA
TACACTTGAAATATAGAAGTTATGTTTTAAATATCTCTGTTTTAGGAGTTCACATATAGTTCAGCATTTATTGTTTAGGAGTATAATTTT
ATTTTATCTAAAATAATAGTCTATTTTTTCTTTTGTATTTTGTTATAATCTTAAGCAACAAAGAAAAAACCCTAATATTTGAATCTATTT
ATGTCTTTCAATTTAAATTCACTTCAGTTTTTGTTATTGTAATATATTTACTTTTACATGGTTATAATCACTTTATATTTTTAATGTTTT
TTTCACTTAATATTTTATATATACATTTCCATGTATTGATGTAGTTAGTCCACATTTAAATTTTTATAGAATTATATAGTTTTTGAAAAA
TACAGTCAGTAGATGTTTTATTTTTTAGCTATTCAGTTATGTTTATAAGTTTGCATAGCTACTTCTCGACATTTGGTTTGTTTTAATTTT
TTTGTATCATAATAGTCCTATTTTTTTTTCAAGTTGGAGTGAATGTTTTTAGTTTTAAGATAGATAGGAGACACTTTTTTATCACATGTA
GTCACAACCTGTTTTGTTTTTGTAAAACATAGGAAGTCTCTTTAATGCAATGATTTGTTTTATATTTGGACTAAGGTTCTTGAGCTTATC
TCCCAAGGTACTTTCCATAATTTAACACAGCTTCTATAAAAGTGACTTCATGCTTACTTGTGGATCATTCTTGCTGCTTAAGATGAAAAG
CATTGGTTTTTTAAAATTAGAGAATAAAATATGTATTTAAATTTTTGGTGTGTTCACATAAAGGGATGTAGCTAAAATGTTTTCATAGGC
TATTATATATTCTCGCAGCATTTCCAGTTAAGAGGATATTAGGTATATAATTCTCTTCTTAACCGAATGTCAGATGGTCTTACGCCACAG
GGTGCAGGTAACCCTTGGTCTGTAAGCACCACCGATCCAGGGATCATTGTCTAAATAGGTTACTATTGTTTGTTTCATCTTGCTTTTGCA
TTTTTATTTTTTAATTTCCAAATTTTAAGTGTTCCCTCTTTGGGGCAAATTCTTATAAAAATGTTTATTGTAAAGTTATATATTTTGTCT
ACGATGGGATTATGCACTTCCCAATTGGGATTTTACATCTGGATTTTTAGTCATTCTAAAAAACACCTAATTATTAAAACATTTATAGAG
TGCCTACTGTATGCATGAGTTGAGTTGCTTCTGAGGTACATTTTGAATGACAGCATATTGTAAGAAAAAAAAAGGTGAATAAAATTTGAC

>86848_86848_5_SSR3-TRPC1_SSR3_chr3_156272746_ENST00000476217_TRPC1_chr3_142521011_ENST00000273482_length(amino acids)=318AA_BP=50
MFSPAAPPWLLKAAPNSSLRRTCSCRISAAISRPSPPRSSSETRSSCLPSPSISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTS
KEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANH
EDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTS

--------------------------------------------------------------
>86848_86848_6_SSR3-TRPC1_SSR3_chr3_156272746_ENST00000476217_TRPC1_chr3_142521011_ENST00000476941_length(transcript)=1163nt_BP=169nt
GGCTCTACGTTCCCTGTTCTCGCCTGCAGCTCCGCCATGGCTCCTAAAGGCAGCTCCAAACAGCAGTCTGAGGAGGACCTGCTCCTGCAG
GATTTCAGCCGCAATCTCTCGGCCAAGTCCTCCGCGCTCTTCTTCGGAAACGCGTTCATCGTGTCTGCCATCCCCATCTATTTCAATGGG
ACAGATGTTACAAGATTTTGGAAAATTTCTTGGGATGTTTCTTCTTGTTTTGTTTTCTTTCACAATTGGACTGACACAACTGTATGATAA
AGGATATACTTCAAAGGAGCAGAAGGACTGTGTAGGCATCTTCTGTGAACAGCAAAGCAATGATACCTTCCATTCGTTCATTGGCACCTG
CTTTGCTTTGTTCTGGTATATTTTCTCCTTAGCGCATGTGGCAATCTTTGTCACAAGATTTAGCTATGGAGAAGAACTGCAGTCCTTTGT
GGGAGCTGTCATTGTTGGTACATACAATGTCGTGGTTGTGATTGTGCTTACCAAACTGCTGGTGGCAATGCTTCATAAAAGCTTTCAGTT
GATAGCAAATCATGAAGACAAAGAATGGAAGTTTGCTCGAGCAAAATTATGGCTTAGCTACTTTGATGACAAATGTACGTTACCTCCACC
TTTCAACATCATTCCCTCACCAAAGACTATCTGCTATATGATTAGTAGCCTCAGTAAGTGGATTTGCTCTCATACATCAAAAGGCAAGGT
CAAACGGCAAAACAGTTTAAAGGAATGGAGGAATTTGAAACAGAAGAGAGATGAAAACTATCAAAAAGTGATGTGCTGCCTAGTGCATCG
TTACTTGACTTCCATGAGACAGAAGATGCAAAGTACAGATCAGGCAACTGTGGAAAATCTAAACGAACTGCGCCAAGATCTGTCAAAATT
CCGAAATGAAATAAGGGATTTACTTGGCTTTCGGACTTCTAAATATGCTATGTTTTATCCAAGAAATTAACCATTTTCTAAATCATGGAG
CGAATAATTTTCAATAACAGATCCAAAAGACTATATTGCATAACTTGCAATGAAATTAATGAGATATATATTGAAATAAAGAATTATGTA

>86848_86848_6_SSR3-TRPC1_SSR3_chr3_156272746_ENST00000476217_TRPC1_chr3_142521011_ENST00000476941_length(amino acids)=318AA_BP=50
MFSPAAPPWLLKAAPNSSLRRTCSCRISAAISRPSPPRSSSETRSSCLPSPSISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTS
KEQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAVIVGTYNVVVVIVLTKLLVAMLHKSFQLIANH
EDKEWKFARAKLWLSYFDDKCTLPPPFNIIPSPKTICYMISSLSKWICSHTSKGKVKRQNSLKEWRNLKQKRDENYQKVMCCLVHRYLTS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SSR3-TRPC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SSR3-TRPC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SSR3-TRPC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource