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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ST3GAL2-COG4 (FusionGDB2 ID:86935)

Fusion Gene Summary for ST3GAL2-COG4

check button Fusion gene summary
Fusion gene informationFusion gene name: ST3GAL2-COG4
Fusion gene ID: 86935
HgeneTgene
Gene symbol

ST3GAL2

COG4

Gene ID

6483

25839

Gene nameST3 beta-galactoside alpha-2,3-sialyltransferase 2component of oligomeric golgi complex 4
SynonymsGal-NAc6S|SIAT4B|ST3GALII|ST3GalA.2CDG2J|COD1|SWILS
Cytomap

16q22.1

16q22.1

Type of geneprotein-codingprotein-coding
DescriptionCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferaseSIAT4-BST3Gal IIalpha 2,3-ST 2beta-galactoside alpha-2,3-sialyltransferase 2sialyltransferase 4B (beta-galactosidase alpha-2,3-siaconserved oligomeric Golgi complex subunit 4COG complex subunit 4complexed with Dor1pconserved oligomeric Golgi complex protein 4
Modification date2020031320200320
UniProtAcc.

Q9H9E3

Ensembl transtripts involved in fusion geneENST00000342907, ENST00000393640, 
ENST00000566097, 		ENST00000393612, 
ENST00000564653, ENST00000323786, 
Fusion gene scores* DoF score4 X 8 X 6=19212 X 11 X 12=1584
# samples 1223
** MAII scorelog2(12/192*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/1584*10)=-2.78386656913523
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ST3GAL2 [Title/Abstract] AND COG4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointST3GAL2(70432094)-COG4(70524295), # samples:2
ST3GAL2(70472851)-COG4(70517872), # samples:2
ST3GAL2(70422270)-COG4(70534994), # samples:2
Anticipated loss of major functional domain due to fusion event.ST3GAL2-COG4 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
ST3GAL2-COG4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ST3GAL2-COG4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneST3GAL2

GO:0006486

protein glycosylation

9266697

HgeneST3GAL2

GO:0009101

glycoprotein biosynthetic process

9266697

HgeneST3GAL2

GO:0009247

glycolipid biosynthetic process

9266697

HgeneST3GAL2

GO:0009312

oligosaccharide biosynthetic process

9266697

HgeneST3GAL2

GO:0030259

lipid glycosylation

9266697

HgeneST3GAL2

GO:0097503

sialylation

9266697

HgeneST3GAL2

GO:1990743

protein sialylation

9266697


check buttonFusion gene breakpoints across ST3GAL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across COG4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AA-3850ST3GAL2chr16

70432094

-COG4chr16

70524295

-
ChimerDB4ESCATCGA-L5-A4OJ-01AST3GAL2chr16

70472852

-COG4chr16

70517872

-
ChimerDB4ESCATCGA-L5-A4OJST3GAL2chr16

70472851

-COG4chr16

70517872

-
ChimerDB4OVTCGA-13-1411-01AST3GAL2chr16

70422270

-COG4chr16

70534994

-
ChimerDB4OVTCGA-13-1411ST3GAL2chr16

70422269

-COG4chr16

70534994

-
ChimerDB4OVTCGA-29-1697-01AST3GAL2chr16

70432095

-COG4chr16

70524295

-
ChimerDB4OVTCGA-29-1697ST3GAL2chr16

70432094

-COG4chr16

70524295

-
ChimerDB4UCECTCGA-EY-A1GC-01AST3GAL2chr16

70415100

-COG4chr16

70543924

-


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Fusion Gene ORF analysis for ST3GAL2-COG4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000342907ENST00000393612ST3GAL2chr16

70432094

-COG4chr16

70524295

-
5CDS-intronENST00000342907ENST00000393612ST3GAL2chr16

70422270

-COG4chr16

70534994

-
5CDS-intronENST00000342907ENST00000393612ST3GAL2chr16

70422269

-COG4chr16

70534994

-
5CDS-intronENST00000342907ENST00000393612ST3GAL2chr16

70432095

-COG4chr16

70524295

-
5CDS-intronENST00000342907ENST00000564653ST3GAL2chr16

70432094

-COG4chr16

70524295

-
5CDS-intronENST00000342907ENST00000564653ST3GAL2chr16

70422270

-COG4chr16

70534994

-
5CDS-intronENST00000342907ENST00000564653ST3GAL2chr16

70422269

-COG4chr16

70534994

-
5CDS-intronENST00000342907ENST00000564653ST3GAL2chr16

70432095

-COG4chr16

70524295

-
5CDS-intronENST00000393640ENST00000393612ST3GAL2chr16

70432094

-COG4chr16

70524295

-
5CDS-intronENST00000393640ENST00000393612ST3GAL2chr16

70422270

-COG4chr16

70534994

-
5CDS-intronENST00000393640ENST00000393612ST3GAL2chr16

70422269

-COG4chr16

70534994

-
5CDS-intronENST00000393640ENST00000393612ST3GAL2chr16

70432095

-COG4chr16

70524295

-
5CDS-intronENST00000393640ENST00000564653ST3GAL2chr16

70432094

-COG4chr16

70524295

-
5CDS-intronENST00000393640ENST00000564653ST3GAL2chr16

70422270

-COG4chr16

70534994

-
5CDS-intronENST00000393640ENST00000564653ST3GAL2chr16

70422269

-COG4chr16

70534994

-
5CDS-intronENST00000393640ENST00000564653ST3GAL2chr16

70432095

-COG4chr16

70524295

-
5UTR-3CDSENST00000342907ENST00000323786ST3GAL2chr16

70472852

-COG4chr16

70517872

-
5UTR-3CDSENST00000342907ENST00000323786ST3GAL2chr16

70472851

-COG4chr16

70517872

-
5UTR-3CDSENST00000566097ENST00000323786ST3GAL2chr16

70472852

-COG4chr16

70517872

-
5UTR-3CDSENST00000566097ENST00000323786ST3GAL2chr16

70472851

-COG4chr16

70517872

-
5UTR-intronENST00000342907ENST00000393612ST3GAL2chr16

70472852

-COG4chr16

70517872

-
5UTR-intronENST00000342907ENST00000393612ST3GAL2chr16

70472851

-COG4chr16

70517872

-
5UTR-intronENST00000342907ENST00000564653ST3GAL2chr16

70472852

-COG4chr16

70517872

-
5UTR-intronENST00000342907ENST00000564653ST3GAL2chr16

70472851

-COG4chr16

70517872

-
5UTR-intronENST00000566097ENST00000393612ST3GAL2chr16

70472852

-COG4chr16

70517872

-
5UTR-intronENST00000566097ENST00000393612ST3GAL2chr16

70472851

-COG4chr16

70517872

-
5UTR-intronENST00000566097ENST00000564653ST3GAL2chr16

70472852

-COG4chr16

70517872

-
5UTR-intronENST00000566097ENST00000564653ST3GAL2chr16

70472851

-COG4chr16

70517872

-
Frame-shiftENST00000342907ENST00000323786ST3GAL2chr16

70432094

-COG4chr16

70524295

-
Frame-shiftENST00000342907ENST00000323786ST3GAL2chr16

70422270

-COG4chr16

70534994

-
Frame-shiftENST00000342907ENST00000323786ST3GAL2chr16

70422269

-COG4chr16

70534994

-
Frame-shiftENST00000342907ENST00000323786ST3GAL2chr16

70432095

-COG4chr16

70524295

-
In-frameENST00000393640ENST00000323786ST3GAL2chr16

70432094

-COG4chr16

70524295

-
In-frameENST00000393640ENST00000323786ST3GAL2chr16

70422270

-COG4chr16

70534994

-
In-frameENST00000393640ENST00000323786ST3GAL2chr16

70422269

-COG4chr16

70534994

-
In-frameENST00000393640ENST00000323786ST3GAL2chr16

70432095

-COG4chr16

70524295

-
intron-3CDSENST00000342907ENST00000323786ST3GAL2chr16

70415100

-COG4chr16

70543924

-
intron-3CDSENST00000342907ENST00000393612ST3GAL2chr16

70415100

-COG4chr16

70543924

-
intron-3CDSENST00000393640ENST00000323786ST3GAL2chr16

70472852

-COG4chr16

70517872

-
intron-3CDSENST00000393640ENST00000323786ST3GAL2chr16

70472851

-COG4chr16

70517872

-
intron-3CDSENST00000393640ENST00000323786ST3GAL2chr16

70415100

-COG4chr16

70543924

-
intron-3CDSENST00000393640ENST00000393612ST3GAL2chr16

70415100

-COG4chr16

70543924

-
intron-3CDSENST00000566097ENST00000323786ST3GAL2chr16

70432094

-COG4chr16

70524295

-
intron-3CDSENST00000566097ENST00000323786ST3GAL2chr16

70422270

-COG4chr16

70534994

-
intron-3CDSENST00000566097ENST00000323786ST3GAL2chr16

70422269

-COG4chr16

70534994

-
intron-3CDSENST00000566097ENST00000323786ST3GAL2chr16

70432095

-COG4chr16

70524295

-
intron-3CDSENST00000566097ENST00000323786ST3GAL2chr16

70415100

-COG4chr16

70543924

-
intron-3CDSENST00000566097ENST00000393612ST3GAL2chr16

70415100

-COG4chr16

70543924

-
intron-intronENST00000342907ENST00000564653ST3GAL2chr16

70415100

-COG4chr16

70543924

-
intron-intronENST00000393640ENST00000393612ST3GAL2chr16

70472852

-COG4chr16

70517872

-
intron-intronENST00000393640ENST00000393612ST3GAL2chr16

70472851

-COG4chr16

70517872

-
intron-intronENST00000393640ENST00000564653ST3GAL2chr16

70472852

-COG4chr16

70517872

-
intron-intronENST00000393640ENST00000564653ST3GAL2chr16

70472851

-COG4chr16

70517872

-
intron-intronENST00000393640ENST00000564653ST3GAL2chr16

70415100

-COG4chr16

70543924

-
intron-intronENST00000566097ENST00000393612ST3GAL2chr16

70432094

-COG4chr16

70524295

-
intron-intronENST00000566097ENST00000393612ST3GAL2chr16

70422270

-COG4chr16

70534994

-
intron-intronENST00000566097ENST00000393612ST3GAL2chr16

70422269

-COG4chr16

70534994

-
intron-intronENST00000566097ENST00000393612ST3GAL2chr16

70432095

-COG4chr16

70524295

-
intron-intronENST00000566097ENST00000564653ST3GAL2chr16

70432094

-COG4chr16

70524295

-
intron-intronENST00000566097ENST00000564653ST3GAL2chr16

70422270

-COG4chr16

70534994

-
intron-intronENST00000566097ENST00000564653ST3GAL2chr16

70422269

-COG4chr16

70534994

-
intron-intronENST00000566097ENST00000564653ST3GAL2chr16

70432095

-COG4chr16

70524295

-
intron-intronENST00000566097ENST00000564653ST3GAL2chr16

70415100

-COG4chr16

70543924

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000393640ST3GAL2chr1670422269-ENST00000323786COG4chr1670534994-4571282121084129673
ENST00000393640ST3GAL2chr1670422270-ENST00000323786COG4chr1670534994-4571282121084129673

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000393640ENST00000323786ST3GAL2chr1670422269-COG4chr1670534994-0.0088269810.99117297
ENST00000393640ENST00000323786ST3GAL2chr1670422270-COG4chr1670534994-0.0088269810.99117297

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Fusion Genomic Features for ST3GAL2-COG4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ST3GAL2-COG4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:70432094/chr16:70524295)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.COG4

Q9H9E3

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Required for normal Golgi function (PubMed:19536132, PubMed:30290151). Plays a role in SNARE-pin assembly and Golgi-to-ER retrograde transport via its interaction with SCFD1 (PubMed:19536132). {ECO:0000269|PubMed:19536132, ECO:0000269|PubMed:30290151}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneST3GAL2chr16:70422269chr16:70534994ENST00000342907-471_6237351.0Topological domainCytoplasmic
HgeneST3GAL2chr16:70422269chr16:70534994ENST00000393640-361_6237351.0Topological domainCytoplasmic
HgeneST3GAL2chr16:70422270chr16:70534994ENST00000342907-471_6237351.0Topological domainCytoplasmic
HgeneST3GAL2chr16:70422270chr16:70534994ENST00000393640-361_6237351.0Topological domainCytoplasmic
HgeneST3GAL2chr16:70432094chr16:70524295ENST00000342907-271_6113351.0Topological domainCytoplasmic
HgeneST3GAL2chr16:70432094chr16:70524295ENST00000393640-161_6113351.0Topological domainCytoplasmic
HgeneST3GAL2chr16:70432095chr16:70524295ENST00000342907-271_6113351.0Topological domainCytoplasmic
HgeneST3GAL2chr16:70432095chr16:70524295ENST00000393640-161_6113351.0Topological domainCytoplasmic
HgeneST3GAL2chr16:70422269chr16:70534994ENST00000342907-477_27237351.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneST3GAL2chr16:70422269chr16:70534994ENST00000393640-367_27237351.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneST3GAL2chr16:70422270chr16:70534994ENST00000342907-477_27237351.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneST3GAL2chr16:70422270chr16:70534994ENST00000393640-367_27237351.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneST3GAL2chr16:70432094chr16:70524295ENST00000342907-277_27113351.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneST3GAL2chr16:70432094chr16:70524295ENST00000393640-167_27113351.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneST3GAL2chr16:70432095chr16:70524295ENST00000342907-277_27113351.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneST3GAL2chr16:70432095chr16:70524295ENST00000393640-167_27113351.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneCOG4chr16:70422269chr16:70534994ENST0000039361208618_7400338.0RegionD domain
TgeneCOG4chr16:70422269chr16:70534994ENST0000039361208741_7850338.0RegionE domain%3B essential for proper cell surface glycosylation
TgeneCOG4chr16:70422270chr16:70534994ENST0000039361208618_7400338.0RegionD domain
TgeneCOG4chr16:70422270chr16:70534994ENST0000039361208741_7850338.0RegionE domain%3B essential for proper cell surface glycosylation
TgeneCOG4chr16:70432094chr16:70524295ENST0000039361208618_7400338.0RegionD domain
TgeneCOG4chr16:70432094chr16:70524295ENST0000039361208741_7850338.0RegionE domain%3B essential for proper cell surface glycosylation
TgeneCOG4chr16:70432095chr16:70524295ENST0000039361208618_7400338.0RegionD domain
TgeneCOG4chr16:70432095chr16:70524295ENST0000039361208741_7850338.0RegionE domain%3B essential for proper cell surface glycosylation

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneST3GAL2chr16:70422269chr16:70534994ENST00000342907-4728_350237351.0Topological domainLumenal
HgeneST3GAL2chr16:70422269chr16:70534994ENST00000393640-3628_350237351.0Topological domainLumenal
HgeneST3GAL2chr16:70422270chr16:70534994ENST00000342907-4728_350237351.0Topological domainLumenal
HgeneST3GAL2chr16:70422270chr16:70534994ENST00000393640-3628_350237351.0Topological domainLumenal
HgeneST3GAL2chr16:70432094chr16:70524295ENST00000342907-2728_350113351.0Topological domainLumenal
HgeneST3GAL2chr16:70432094chr16:70524295ENST00000393640-1628_350113351.0Topological domainLumenal
HgeneST3GAL2chr16:70432095chr16:70524295ENST00000342907-2728_350113351.0Topological domainLumenal
HgeneST3GAL2chr16:70432095chr16:70524295ENST00000393640-1628_350113351.0Topological domainLumenal


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Fusion Gene Sequence for ST3GAL2-COG4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>86935_86935_1_ST3GAL2-COG4_ST3GAL2_chr16_70422269_ENST00000393640_COG4_chr16_70534994_ENST00000323786_length(transcript)=4571nt_BP=2821nt
AATATGCTCGTTCCATTCCCTGCTGGCTTTGTGGCCACAAATGGAGGGGCAGCTACGTTTCTTGAACACAGAGCCTGAGAGGCCTTGTAT
GCAGCTGCTGGAAGCAGCCAGGAGACCCCAAAAGTGGGCTGGAGACTTCAACAAGGACAGGGAACAGGGCTGCACTGAGAGGCCCAGGGG
CTAGGTCAGCAGCACCGCTAGGCAGATTTGGAGGGGAGCTGGGGAGAGGCGAGGCAGCCAGCTTTGCAAGATTCCCACGGCACACAGCCA
GTGCTCAGGGGTTCCCTTCTCAGCGTTCCTCTCACCTGGTGTGGCTCCCTCACGCTTGGCATGGATCTGAGCTCCTTTCCTTATGGCTGA
GACCCAAACTGCCTACAAGTGGCCTTTTCTCCCTGTTCTTGCCTGCAAGGGCAGCATGGGGCCTCAGGCTGTCAGTGCTACCAGGGACGC
TGGCATTCACTTTGTCCATAATGTACAGATGGATGTAGACAACTGCCCTCAGGGCTGTCCGGGGGCAGGACCAAGCCCAGCAACCACACC
TCCTGACACAGCCAGGTTCTCCCCCAACGGCGGAGCTGACAGGACTGTTCATGGTTCATTGAGTGGACCCAGCAATACCTCATCGATAAT
CCACAGTCGAGAGAAGAGGGGCGGTCAGAGACCGGCCAGCCCTCCCTTCTGATTGGGAGAGGCCTCTGCAGGCACTGACAGGCTCCAGAG
AGTGCTGTGGGGGGCAGTCAGTGTCCATAGTCCCCTGGAATCTTCTCTGGGCTGTTTTCTCTGACTTTTCACCTGAAATTAACTGTACAT
AGCTGGGCTAGGAACTCTCTAAATCTGAAAGCATGTGGCTTAGGGAAAATCACTTGACTCGTTTACCTTCTGGCTAAGAAGTGAAGACTC
TGGGCTAATCTAGTCCTCCAGGCCCTGGAGTCCCACACAGTGATGCTATCTGTGCAGCTAGAGGGCAGAGCCCTTGGTCATGTCCACCCT
CTGATTAAGTGGGCATCTCCTCTCCTGCTAGCTTTGGGGCTTGGGGTGGGGCTGGGACAAAGCCTGGTGCCCGTGTGATTCATCCGCACA
TTATTTCTCCTCTCTGCCATTCTAGGGTCGTGCTGCGGCAGCCTGGCGCCCGACATGTGAAGGGGAACCTGCCAGGGGATTACTGTGAGC
TCACAGCAGGATAGGCTGGCCCCGGGGGAGTGGGGATGGGCAGAACCTGGGCCAGGAGTATTAGGAAGGAGACCTGGACCCTGGTAGGGA
GCTCAGCACAAGCTCGCCTGACCCAGATGGTATTGGACACAGTGCCCCGCTGAACAGCAGCTGTTCCCAGCGCCAGAGGACCCCACAGCC
ACAGTAGGAGCTTTGCGACCCCTACGCAACTGCAGCTGGGGCTGGGGCCACCAGGAGAAGGGACCAGCACCTCAGATGGGAAGCAGAAGG
GCAAGACCTACTGCGGAAAGGATCTCGATCTCTGCAGCGGAGTTTTCCCACACTCACAGAGCTTCCTGTTTTTGTCCTCTCAGGGTTGGG
GTCTGGCTCCCCTCCTCTGGCAGAGGTTTTGGGCCAGGAGGTGGGACAACACTTGCATGGAACCCAAGTCCCCTGAAGCCCCTGTGCTCT
CTGTTGTGATTGGAGTTCTAGGGCTTCCCCGCTGCCGGGAACGAGGGGCCGCCTCATTGTCTGCTCATGAACCACAAGGACCCCGACTGC
TCCAGACTGGATTATTTCAAGCCGCCAAAGAGGGGGACCCCTAGAGCTGGCAGCCAGCAATCCCAAGGGACTAGAGGGCTGCAATGGACT
GACCTCCCCCTCACCAGGGTGGCAGGAGAGGCAGAGCCTCTGTGGCCTAGCTAGTGACGGAGAGACCCGATGAAGCCCTAAGCAGGGGCC
CCGCCTGACTCAGGGACAGGACAGCCACTCCTGCCAACGTGTGTTCTCCCTACATGAGGGAGGGCGTGGCAAGGGACCCCTGCCACTGTC
CCCTGCTGCAGCACGTGCCCCTATGCCCTTTGCATGTGGTGCCAGAATAGGCAGGCTACGCCGTGGCTGGCCCCTCAGCGGGCTGGGAAA
AGAGTGGCCACGGTGACCGTCACCCGCCTGCCGGCACCATGAAGTGCTCCCTGCGGGTGTGGTTCCTCTCCGTGGCCTTCCTGCTGGTGT
TCATCATGTCCCTGCTCTTCACCTACTCGCACCACAGCATGGCCACGCTCCCCTACCTGGACTCAGGGGCCCTGGATGGGACGCACCGGG
TGAAGCTGGTGCCCGGCTATGCCGGCCTGCAGCGCCTCAGCAAGGAGAGGCTCTCGGGCAAGAGCTGTGCCTGTCGCCGCTGCATGGGCG
ATGCCGGTGCCTCCGACTGGTTTGACAGCCACTTTGACGGTAACATTTCCCCCGTCTGGACCCGAGAGAACATGGATCTTCCACCGGACG
TCCAGAGGTGGTGGATGATGCTGCAGCCCCAGTTCAAGTCACACAACACCAATGAGGTGCTGGAGAAGCTGTTCCAGATAGTGCCTGGCG
AGAACCCCTACCGCTTCCGGGACCCCCACCAGTGCCGGCGCTGTGCCGTGGTGGGGAACTCGGGCAACCTGCGGGGCTCTGGCTATGGGC
AGGACGTGGACGGGCACAACTTCATCATGAGGATGAATCAGGCGCCAACCGTGGGCTTTGAGCAGGATGTTGGCAGCCGAACCACCCACC
ATTTCATGTACCCTGAGAGTGCCAAGAACCTGCCCGCCAACGTCAGCTTCGTGCTGGTGCCCTTCAAGGTCCTGGACCTTCTGTGGATCG
CCAGCGCCTTGTCCACGGGGCAGATCCGATTAGAACTGGACCCCATCCTGACTGAGGTCACCCTGATGAATGCCCGCAGTGAGCTATACT
TACGCTTCCTCAAGAAGAGGATTAGCTCTGATTTTGAGGTGGGAGACTCCATGGCCTCAGAGGAAGTAAAGCAAGAGCACCAGAAGTGTC
TGGACAAACTCCTCAATAACTGCCTTTTGAGCTGTACCATGCAGGAGCTAATTGGCTTATATGTTACCATGGAGGAGTACTTCATGAGGG
AGACTGTCAATAAGGCTGTGGCTCTGGACACCTATGAGAAGGGCCAGCTGACATCCAGCATGGTGGATGATGTCTTCTACATTGTTAAGA
AGTGCATTGGGCGGGCTCTGTCCAGCTCCAGCATTGACTGTCTCTGTGCCATGATCAACCTCGCCACCACAGAGCTGGAGTCTGACTTCA
GGGATGTTCTGTGTAATAAGCTGCGGATGGGCTTTCCTGCCACCACCTTCCAGGACATCCAGCGCGGGGTGACAAGTGCCGTGAACATCA
TGCACAGCAGCCTCCAGCAAGGCAAATTTGACACAAAAGGCATCGAGAGTACTGACGAGGCGAAGATGTCCTTCCTGGTGACTCTGAACA
ACGTGGAAGTCTGCAGTGAAAACATCTCCACTCTGAAGAAGACACTGGAGAGTGACTGCACCAAGCTCTTCAGCCAGGGCATTGGAGGGG
AGCAGGCCCAGGCCAAGTTTGACAGCTGCCTTTCTGACTTGGCCGCCGTGTCCAACAAATTCCGAGACCTCTTGCAGGAAGGGCTGACGG
AGCTCAACAGCACAGCCATCAAGCCACAGGTGCAGCCTTGGATCAACAGCTTTTTCTCCGTCTCCCACAACATCGAGGAGGAAGAATTCA
ATGACTATGAGGCCAACGACCCTTGGGTACAACAGTTCATCCTTAACCTGGAGCAGCAAATGGCAGAGTTCAAGGCCAGCCTGTCCCCGG
TCATCTACGACAGCCTAACCGGCCTCATGACTAGCCTTGTTGCCGTCGAGTTGGAGAAAGTGGTGCTGAAATCCACCTTTAACCGGCTGG
GTGGTCTGCAGTTTGACAAGGAGCTGAGGTCGCTCATTGCCTACCTTACCACGGTGACCACCTGGACCATCCGAGACAAGTTTGCCCGGC
TCTCCCAGATGGCCACCATCCTCAATCTGGAGCGGGTGACCGAGATCCTCGATTACTGGGGACCCAATTCCGGCCCATTGACGTGGCGCC
TCACCCCTGCTGAAGTGCGCCAGGTGCTGGCCCTGCGGATAGACTTCCGCAGTGAAGATATCAAGAGGCTGCGCCTGTAGCTGCCTGGAT
GAGCACACCTGGCTCATCACACTTGCAGGCCTGTTCCCTAAGGGGCCCCAGCCAAGGAGCTGAGCGAGGCTGTCTGGCTTGGGGGAGATC
TGACAGCCCAGACCTTTCTACGGCTGGCAGCAGAGAAACAAAGTCTGGACCCACTCCATGCTCTGCCCTCAGACCTGGCCAGGTGATGCT
CTGGGGGCAGCATCTCCCCACCGAGAGAAGCGGGCTCCTAATGAGGTGGGAAAGCCACGGCAGGCAGCGAGCAGCCCAGGCCAGCTTTCT
GCATGGATGGTCAGTCTCTTGCCCTCAAACACTACAGCAAACAAGCTACCCCTGCCAGTCCTAGACAACTTGGGTACATCTGGGGACCTA

>86935_86935_1_ST3GAL2-COG4_ST3GAL2_chr16_70422269_ENST00000393640_COG4_chr16_70534994_ENST00000323786_length(amino acids)=673AA_BP=238
MKCSLRVWFLSVAFLLVFIMSLLFTYSHHSMATLPYLDSGALDGTHRVKLVPGYAGLQRLSKERLSGKSCACRRCMGDAGASDWFDSHFD
GNISPVWTRENMDLPPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPYRFRDPHQCRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMN
QAPTVGFEQDVGSRTTHHFMYPESAKNLPANVSFVLVPFKVLDLLWIASALSTGQIRLELDPILTEVTLMNARSELYLRFLKKRISSDFE
VGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELIGLYVTMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRALSSSSID
CLCAMINLATTELESDFRDVLCNKLRMGFPATTFQDIQRGVTSAVNIMHSSLQQGKFDTKGIESTDEAKMSFLVTLNNVEVCSENISTLK
KTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSNKFRDLLQEGLTELNSTAIKPQVQPWINSFFSVSHNIEEEEFNDYEANDPWVQQF
ILNLEQQMAEFKASLSPVIYDSLTGLMTSLVAVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDKFARLSQMATILNLERV

--------------------------------------------------------------
>86935_86935_2_ST3GAL2-COG4_ST3GAL2_chr16_70422270_ENST00000393640_COG4_chr16_70534994_ENST00000323786_length(transcript)=4571nt_BP=2821nt
AATATGCTCGTTCCATTCCCTGCTGGCTTTGTGGCCACAAATGGAGGGGCAGCTACGTTTCTTGAACACAGAGCCTGAGAGGCCTTGTAT
GCAGCTGCTGGAAGCAGCCAGGAGACCCCAAAAGTGGGCTGGAGACTTCAACAAGGACAGGGAACAGGGCTGCACTGAGAGGCCCAGGGG
CTAGGTCAGCAGCACCGCTAGGCAGATTTGGAGGGGAGCTGGGGAGAGGCGAGGCAGCCAGCTTTGCAAGATTCCCACGGCACACAGCCA
GTGCTCAGGGGTTCCCTTCTCAGCGTTCCTCTCACCTGGTGTGGCTCCCTCACGCTTGGCATGGATCTGAGCTCCTTTCCTTATGGCTGA
GACCCAAACTGCCTACAAGTGGCCTTTTCTCCCTGTTCTTGCCTGCAAGGGCAGCATGGGGCCTCAGGCTGTCAGTGCTACCAGGGACGC
TGGCATTCACTTTGTCCATAATGTACAGATGGATGTAGACAACTGCCCTCAGGGCTGTCCGGGGGCAGGACCAAGCCCAGCAACCACACC
TCCTGACACAGCCAGGTTCTCCCCCAACGGCGGAGCTGACAGGACTGTTCATGGTTCATTGAGTGGACCCAGCAATACCTCATCGATAAT
CCACAGTCGAGAGAAGAGGGGCGGTCAGAGACCGGCCAGCCCTCCCTTCTGATTGGGAGAGGCCTCTGCAGGCACTGACAGGCTCCAGAG
AGTGCTGTGGGGGGCAGTCAGTGTCCATAGTCCCCTGGAATCTTCTCTGGGCTGTTTTCTCTGACTTTTCACCTGAAATTAACTGTACAT
AGCTGGGCTAGGAACTCTCTAAATCTGAAAGCATGTGGCTTAGGGAAAATCACTTGACTCGTTTACCTTCTGGCTAAGAAGTGAAGACTC
TGGGCTAATCTAGTCCTCCAGGCCCTGGAGTCCCACACAGTGATGCTATCTGTGCAGCTAGAGGGCAGAGCCCTTGGTCATGTCCACCCT
CTGATTAAGTGGGCATCTCCTCTCCTGCTAGCTTTGGGGCTTGGGGTGGGGCTGGGACAAAGCCTGGTGCCCGTGTGATTCATCCGCACA
TTATTTCTCCTCTCTGCCATTCTAGGGTCGTGCTGCGGCAGCCTGGCGCCCGACATGTGAAGGGGAACCTGCCAGGGGATTACTGTGAGC
TCACAGCAGGATAGGCTGGCCCCGGGGGAGTGGGGATGGGCAGAACCTGGGCCAGGAGTATTAGGAAGGAGACCTGGACCCTGGTAGGGA
GCTCAGCACAAGCTCGCCTGACCCAGATGGTATTGGACACAGTGCCCCGCTGAACAGCAGCTGTTCCCAGCGCCAGAGGACCCCACAGCC
ACAGTAGGAGCTTTGCGACCCCTACGCAACTGCAGCTGGGGCTGGGGCCACCAGGAGAAGGGACCAGCACCTCAGATGGGAAGCAGAAGG
GCAAGACCTACTGCGGAAAGGATCTCGATCTCTGCAGCGGAGTTTTCCCACACTCACAGAGCTTCCTGTTTTTGTCCTCTCAGGGTTGGG
GTCTGGCTCCCCTCCTCTGGCAGAGGTTTTGGGCCAGGAGGTGGGACAACACTTGCATGGAACCCAAGTCCCCTGAAGCCCCTGTGCTCT
CTGTTGTGATTGGAGTTCTAGGGCTTCCCCGCTGCCGGGAACGAGGGGCCGCCTCATTGTCTGCTCATGAACCACAAGGACCCCGACTGC
TCCAGACTGGATTATTTCAAGCCGCCAAAGAGGGGGACCCCTAGAGCTGGCAGCCAGCAATCCCAAGGGACTAGAGGGCTGCAATGGACT
GACCTCCCCCTCACCAGGGTGGCAGGAGAGGCAGAGCCTCTGTGGCCTAGCTAGTGACGGAGAGACCCGATGAAGCCCTAAGCAGGGGCC
CCGCCTGACTCAGGGACAGGACAGCCACTCCTGCCAACGTGTGTTCTCCCTACATGAGGGAGGGCGTGGCAAGGGACCCCTGCCACTGTC
CCCTGCTGCAGCACGTGCCCCTATGCCCTTTGCATGTGGTGCCAGAATAGGCAGGCTACGCCGTGGCTGGCCCCTCAGCGGGCTGGGAAA
AGAGTGGCCACGGTGACCGTCACCCGCCTGCCGGCACCATGAAGTGCTCCCTGCGGGTGTGGTTCCTCTCCGTGGCCTTCCTGCTGGTGT
TCATCATGTCCCTGCTCTTCACCTACTCGCACCACAGCATGGCCACGCTCCCCTACCTGGACTCAGGGGCCCTGGATGGGACGCACCGGG
TGAAGCTGGTGCCCGGCTATGCCGGCCTGCAGCGCCTCAGCAAGGAGAGGCTCTCGGGCAAGAGCTGTGCCTGTCGCCGCTGCATGGGCG
ATGCCGGTGCCTCCGACTGGTTTGACAGCCACTTTGACGGTAACATTTCCCCCGTCTGGACCCGAGAGAACATGGATCTTCCACCGGACG
TCCAGAGGTGGTGGATGATGCTGCAGCCCCAGTTCAAGTCACACAACACCAATGAGGTGCTGGAGAAGCTGTTCCAGATAGTGCCTGGCG
AGAACCCCTACCGCTTCCGGGACCCCCACCAGTGCCGGCGCTGTGCCGTGGTGGGGAACTCGGGCAACCTGCGGGGCTCTGGCTATGGGC
AGGACGTGGACGGGCACAACTTCATCATGAGGATGAATCAGGCGCCAACCGTGGGCTTTGAGCAGGATGTTGGCAGCCGAACCACCCACC
ATTTCATGTACCCTGAGAGTGCCAAGAACCTGCCCGCCAACGTCAGCTTCGTGCTGGTGCCCTTCAAGGTCCTGGACCTTCTGTGGATCG
CCAGCGCCTTGTCCACGGGGCAGATCCGATTAGAACTGGACCCCATCCTGACTGAGGTCACCCTGATGAATGCCCGCAGTGAGCTATACT
TACGCTTCCTCAAGAAGAGGATTAGCTCTGATTTTGAGGTGGGAGACTCCATGGCCTCAGAGGAAGTAAAGCAAGAGCACCAGAAGTGTC
TGGACAAACTCCTCAATAACTGCCTTTTGAGCTGTACCATGCAGGAGCTAATTGGCTTATATGTTACCATGGAGGAGTACTTCATGAGGG
AGACTGTCAATAAGGCTGTGGCTCTGGACACCTATGAGAAGGGCCAGCTGACATCCAGCATGGTGGATGATGTCTTCTACATTGTTAAGA
AGTGCATTGGGCGGGCTCTGTCCAGCTCCAGCATTGACTGTCTCTGTGCCATGATCAACCTCGCCACCACAGAGCTGGAGTCTGACTTCA
GGGATGTTCTGTGTAATAAGCTGCGGATGGGCTTTCCTGCCACCACCTTCCAGGACATCCAGCGCGGGGTGACAAGTGCCGTGAACATCA
TGCACAGCAGCCTCCAGCAAGGCAAATTTGACACAAAAGGCATCGAGAGTACTGACGAGGCGAAGATGTCCTTCCTGGTGACTCTGAACA
ACGTGGAAGTCTGCAGTGAAAACATCTCCACTCTGAAGAAGACACTGGAGAGTGACTGCACCAAGCTCTTCAGCCAGGGCATTGGAGGGG
AGCAGGCCCAGGCCAAGTTTGACAGCTGCCTTTCTGACTTGGCCGCCGTGTCCAACAAATTCCGAGACCTCTTGCAGGAAGGGCTGACGG
AGCTCAACAGCACAGCCATCAAGCCACAGGTGCAGCCTTGGATCAACAGCTTTTTCTCCGTCTCCCACAACATCGAGGAGGAAGAATTCA
ATGACTATGAGGCCAACGACCCTTGGGTACAACAGTTCATCCTTAACCTGGAGCAGCAAATGGCAGAGTTCAAGGCCAGCCTGTCCCCGG
TCATCTACGACAGCCTAACCGGCCTCATGACTAGCCTTGTTGCCGTCGAGTTGGAGAAAGTGGTGCTGAAATCCACCTTTAACCGGCTGG
GTGGTCTGCAGTTTGACAAGGAGCTGAGGTCGCTCATTGCCTACCTTACCACGGTGACCACCTGGACCATCCGAGACAAGTTTGCCCGGC
TCTCCCAGATGGCCACCATCCTCAATCTGGAGCGGGTGACCGAGATCCTCGATTACTGGGGACCCAATTCCGGCCCATTGACGTGGCGCC
TCACCCCTGCTGAAGTGCGCCAGGTGCTGGCCCTGCGGATAGACTTCCGCAGTGAAGATATCAAGAGGCTGCGCCTGTAGCTGCCTGGAT
GAGCACACCTGGCTCATCACACTTGCAGGCCTGTTCCCTAAGGGGCCCCAGCCAAGGAGCTGAGCGAGGCTGTCTGGCTTGGGGGAGATC
TGACAGCCCAGACCTTTCTACGGCTGGCAGCAGAGAAACAAAGTCTGGACCCACTCCATGCTCTGCCCTCAGACCTGGCCAGGTGATGCT
CTGGGGGCAGCATCTCCCCACCGAGAGAAGCGGGCTCCTAATGAGGTGGGAAAGCCACGGCAGGCAGCGAGCAGCCCAGGCCAGCTTTCT
GCATGGATGGTCAGTCTCTTGCCCTCAAACACTACAGCAAACAAGCTACCCCTGCCAGTCCTAGACAACTTGGGTACATCTGGGGACCTA

>86935_86935_2_ST3GAL2-COG4_ST3GAL2_chr16_70422270_ENST00000393640_COG4_chr16_70534994_ENST00000323786_length(amino acids)=673AA_BP=238
MKCSLRVWFLSVAFLLVFIMSLLFTYSHHSMATLPYLDSGALDGTHRVKLVPGYAGLQRLSKERLSGKSCACRRCMGDAGASDWFDSHFD
GNISPVWTRENMDLPPDVQRWWMMLQPQFKSHNTNEVLEKLFQIVPGENPYRFRDPHQCRRCAVVGNSGNLRGSGYGQDVDGHNFIMRMN
QAPTVGFEQDVGSRTTHHFMYPESAKNLPANVSFVLVPFKVLDLLWIASALSTGQIRLELDPILTEVTLMNARSELYLRFLKKRISSDFE
VGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELIGLYVTMEEYFMRETVNKAVALDTYEKGQLTSSMVDDVFYIVKKCIGRALSSSSID
CLCAMINLATTELESDFRDVLCNKLRMGFPATTFQDIQRGVTSAVNIMHSSLQQGKFDTKGIESTDEAKMSFLVTLNNVEVCSENISTLK
KTLESDCTKLFSQGIGGEQAQAKFDSCLSDLAAVSNKFRDLLQEGLTELNSTAIKPQVQPWINSFFSVSHNIEEEEFNDYEANDPWVQQF
ILNLEQQMAEFKASLSPVIYDSLTGLMTSLVAVELEKVVLKSTFNRLGGLQFDKELRSLIAYLTTVTTWTIRDKFARLSQMATILNLERV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ST3GAL2-COG4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneCOG4chr16:70422269chr16:70534994ENST00000393612082_840338.0SCFD1
TgeneCOG4chr16:70422270chr16:70534994ENST00000393612082_840338.0SCFD1
TgeneCOG4chr16:70432094chr16:70524295ENST00000393612082_840338.0SCFD1
TgeneCOG4chr16:70432095chr16:70524295ENST00000393612082_840338.0SCFD1
TgeneCOG4chr16:70422269chr16:70534994ENST000003936120885_1530338.0STX5
TgeneCOG4chr16:70422270chr16:70534994ENST000003936120885_1530338.0STX5
TgeneCOG4chr16:70432094chr16:70524295ENST000003936120885_1530338.0STX5
TgeneCOG4chr16:70432095chr16:70524295ENST000003936120885_1530338.0STX5


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ST3GAL2-COG4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ST3GAL2-COG4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource