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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ST3GAL3-PTPRF (FusionGDB2 ID:86942)

Fusion Gene Summary for ST3GAL3-PTPRF

Fusion gene summary

Fusion gene information	Fusion gene name: ST3GAL3-PTPRF
	Fusion gene ID: 86942
		Hgene	Tgene
	Gene symbol	ST3GAL3	PTPRF
	Gene ID	6487	5792
	Gene name	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	protein tyrosine phosphatase receptor type F
	Synonyms	EIEE15\|MRT12\|SIAT6\|ST3GALII\|ST3Gal III\|ST3GalIII\|ST3N	BNAH2\|LAR
	Cytomap	1p34.1	1p34.2
	Type of gene	protein-coding	protein-coding
	Description	CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferaseGal beta-1,3(4)GlcNAc alpha-2,3 sialyltransferasealpha 2,3-ST 3alpha 2,3-sialyltransferase IIIalpha-2,3-sialyltransferase IIsialyltransferase 6 (N-acetyllacosaminide alpha 2,3-si	receptor-type tyrosine-protein phosphatase FLCA-homologleukocyte antigen-related (LAR) PTP receptorleukocyte antigen-related tyrosine phosphataseleukocyte common antigen relatedprotein tyrosine phosphatase, receptor type, F polypeptidereceptor-linke
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000461375, ENST00000262915, ENST00000330208, ENST00000332628, ENST00000335430, ENST00000347631, ENST00000351035, ENST00000353126, ENST00000361392, ENST00000361400, ENST00000361746, ENST00000361812, ENST00000372362, ENST00000372365, ENST00000372366, ENST00000372367, ENST00000372368, ENST00000372369, ENST00000372372, ENST00000372374, ENST00000372375, ENST00000372377, ENST00000528371, ENST00000531451, ENST00000531816, ENST00000531993, ENST00000533933, ENST00000545417,	ENST00000359947, ENST00000372413, ENST00000372414, ENST00000422171, ENST00000438120, ENST00000496447,
Fusion gene scores	* DoF score	11 X 9 X 8=792	10 X 14 X 6=840
	# samples	12	15
	** MAII score	log2(12/792*10)=-2.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/840*10)=-2.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ST3GAL3 [Title/Abstract] AND PTPRF [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ST3GAL3(44280605)-PTPRF(44069087), # samples:3 PTPRF(44019612)-ST3GAL3(44360054), # samples:2
Anticipated loss of major functional domain due to fusion event.	PTPRF-ST3GAL3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. PTPRF-ST3GAL3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. PTPRF-ST3GAL3 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. ST3GAL3-PTPRF seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. ST3GAL3-PTPRF seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. ST3GAL3-PTPRF seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PTPRF	GO:0099560	synaptic membrane adhesion	26321637

Fusion gene breakpoints across ST3GAL3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PTPRF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-LN-A7HV-01A	ST3GAL3	chr1	44280605	-	PTPRF	chr1	44069087	+
ChimerDB4	ESCA	TCGA-LN-A7HV-01A	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
ChimerDB4	ESCA	TCGA-LN-A7HV	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
ChimerDB4	ESCA	TCGA-LN-A7HV	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+

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Fusion Gene ORF analysis for ST3GAL3-PTPRF

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000461375	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
3UTR-3CDS	ENST00000461375	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
3UTR-3CDS	ENST00000461375	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
3UTR-3CDS	ENST00000461375	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
3UTR-3CDS	ENST00000461375	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
3UTR-3CDS	ENST00000461375	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
3UTR-3CDS	ENST00000461375	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
3UTR-3CDS	ENST00000461375	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
3UTR-3CDS	ENST00000461375	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
3UTR-3CDS	ENST00000461375	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
3UTR-3UTR	ENST00000461375	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
3UTR-3UTR	ENST00000461375	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000262915	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000262915	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000330208	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000330208	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000332628	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000332628	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000335430	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000335430	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000347631	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000347631	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000351035	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000351035	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000353126	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000353126	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000361392	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000361392	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000361400	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000361400	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000361746	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000361746	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000361812	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000361812	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000372362	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000372362	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000372365	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000372365	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000372366	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000372366	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000372367	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000372367	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000372368	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000372368	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000372369	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000372369	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000372372	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000372372	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000372374	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000372374	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000372375	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000372375	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000372377	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000372377	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000528371	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000528371	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000531451	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000531451	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000531816	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000531816	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000531993	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000531993	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000533933	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000533933	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
5CDS-3UTR	ENST00000545417	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
5CDS-3UTR	ENST00000545417	ENST00000496447	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000262915	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000262915	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000262915	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000262915	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000262915	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000262915	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000262915	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000262915	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000262915	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000262915	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000330208	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000330208	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000330208	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000330208	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000330208	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000330208	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000330208	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000330208	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000330208	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000330208	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000332628	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000332628	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000332628	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000332628	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000332628	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000332628	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000332628	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000332628	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000332628	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000332628	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000335430	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000335430	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000335430	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000335430	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000335430	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000335430	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000335430	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000335430	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000335430	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000335430	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000347631	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000347631	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000347631	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000347631	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000347631	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000347631	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000347631	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000347631	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000347631	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000347631	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000351035	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000351035	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000351035	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000351035	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000351035	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000351035	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000351035	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000351035	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000351035	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000351035	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000353126	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000353126	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000353126	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000353126	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000353126	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000353126	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000353126	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000353126	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000353126	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000353126	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000361392	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000361392	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000361392	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000361392	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000361392	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000361392	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000361392	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000361392	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000361392	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000361392	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000361400	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000361400	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000361400	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000361400	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000361400	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000361400	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000361400	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000361400	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000361400	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000361400	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000361746	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000361746	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000361746	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000361746	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000361746	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000361746	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000361746	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000361746	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000361746	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000361746	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000361812	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000361812	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000361812	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000361812	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000361812	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000361812	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000361812	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000361812	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000361812	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000361812	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372362	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372362	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372362	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372362	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372362	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372362	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372362	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372362	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372362	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372362	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372365	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372365	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372365	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372365	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372365	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372365	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372365	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372365	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372365	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372365	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372366	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372366	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372366	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372366	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372366	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372366	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372366	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372366	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372366	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372366	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372367	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372367	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372367	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372367	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372367	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372367	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372367	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372367	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372367	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372367	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372368	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372368	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372368	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372368	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372368	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372368	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372368	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372368	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372368	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372368	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372369	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372369	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372369	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372369	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372369	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372369	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372369	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372369	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372369	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372369	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372372	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372372	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372372	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372372	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372372	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372372	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372372	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372372	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372372	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372372	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372374	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372374	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372374	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372374	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372374	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372374	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372374	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372374	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372374	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372374	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372375	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372375	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372375	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372375	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372375	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372375	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372375	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372375	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372375	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372375	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372377	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372377	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372377	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372377	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372377	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372377	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372377	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372377	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000372377	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000372377	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000528371	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000528371	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000528371	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000528371	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000528371	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000528371	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000528371	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000528371	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000528371	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000528371	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000531451	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000531451	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000531451	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000531451	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000531451	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000531451	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000531451	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000531451	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000531451	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000531451	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000531816	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000531816	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000531816	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000531816	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000531816	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000531816	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000531816	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000531816	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000531816	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000531816	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000531993	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000531993	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000531993	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000531993	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000531993	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000531993	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000531993	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000531993	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000531993	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000531993	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000533933	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000533933	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000533933	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000533933	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000533933	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000533933	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000533933	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000533933	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000533933	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000533933	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000545417	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000545417	ENST00000359947	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000545417	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000545417	ENST00000372413	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000545417	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000545417	ENST00000372414	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000545417	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000545417	ENST00000422171	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+
Frame-shift	ENST00000545417	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069087	+
Frame-shift	ENST00000545417	ENST00000438120	ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for ST3GAL3-PTPRF

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+	1.37E-06	0.9999987
ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+	1.37E-06	0.9999987
ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+	1.37E-06	0.9999987
ST3GAL3	chr1	44280605	+	PTPRF	chr1	44069086	+	1.37E-06	0.9999987

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ST3GAL3-PTPRF

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:44280605/:44069087)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ST3GAL3-PTPRF

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ST3GAL3-PTPRF

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ST3GAL3-PTPRF

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ST3GAL3-PTPRF

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source