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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ST3GAL4-CAMK2G (FusionGDB2 ID:86953)

Fusion Gene Summary for ST3GAL4-CAMK2G

check button Fusion gene summary
Fusion gene informationFusion gene name: ST3GAL4-CAMK2G
Fusion gene ID: 86953
HgeneTgene
Gene symbol

ST3GAL4

CAMK2G

Gene ID

6484

818

Gene nameST3 beta-galactoside alpha-2,3-sialyltransferase 4calcium/calmodulin dependent protein kinase II gamma
SynonymsCGS23|NANTA3|SAT3|SIAT4|SIAT4C|ST-4|ST3GalA.2|ST3GalIV|STZ|gal-NAc6SCAMK|CAMK-II|CAMKG|MRD59
Cytomap

11q24.2

10q22.2

Type of geneprotein-codingprotein-coding
DescriptionCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4alpha 2,3-ST 4alpha 2,3-sialyltransferase IValpha-3-N-acetylneuraminyltransferasebeta-galactoside alpha-2,3-sialyltransferase 4gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferasesiacalcium/calmodulin-dependent protein kinase type II subunit gammacaMK-II subunit gammacalcium/calmodulin-dependent protein kinase (CaM kinase) II gamma
Modification date2020031320200313
UniProtAcc.

Q13555

Ensembl transtripts involved in fusion geneENST00000526756, ENST00000227495, 
ENST00000356132, ENST00000392669, 
ENST00000444328, ENST00000449406, 
ENST00000526727, ENST00000530591, 
ENST00000532243, ENST00000534083, 
ENST00000534457, 
ENST00000305762, 
ENST00000322635, ENST00000322680, 
ENST00000351293, ENST00000372765, 
ENST00000394762, ENST00000423381, 
ENST00000444854, ENST00000472912, 
Fusion gene scores* DoF score7 X 5 X 6=2109 X 8 X 6=432
# samples 711
** MAII scorelog2(7/210*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/432*10)=-1.97352778863881
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ST3GAL4 [Title/Abstract] AND CAMK2G [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointST3GAL4(126275597)-CAMK2G(75574763), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneST3GAL4

GO:0006486

protein glycosylation

8288606

HgeneST3GAL4

GO:0009101

glycoprotein biosynthetic process

8288606

HgeneST3GAL4

GO:0009247

glycolipid biosynthetic process

8288606

HgeneST3GAL4

GO:0009312

oligosaccharide biosynthetic process

8288606

HgeneST3GAL4

GO:0030259

lipid glycosylation

8288606

HgeneST3GAL4

GO:0097503

sialylation

8288606

HgeneST3GAL4

GO:1990743

protein sialylation

8288606


check buttonFusion gene breakpoints across ST3GAL4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CAMK2G (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAW842632ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+


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Fusion Gene ORF analysis for ST3GAL4-CAMK2G

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000526756ENST00000305762ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
3UTR-intronENST00000526756ENST00000322635ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
3UTR-intronENST00000526756ENST00000322680ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
3UTR-intronENST00000526756ENST00000351293ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
3UTR-intronENST00000526756ENST00000372765ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
3UTR-intronENST00000526756ENST00000394762ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
3UTR-intronENST00000526756ENST00000423381ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
3UTR-intronENST00000526756ENST00000444854ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
3UTR-intronENST00000526756ENST00000472912ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000227495ENST00000305762ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000227495ENST00000322635ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000227495ENST00000322680ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000227495ENST00000351293ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000227495ENST00000372765ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000227495ENST00000394762ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000227495ENST00000423381ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000227495ENST00000444854ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000227495ENST00000472912ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000356132ENST00000305762ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000356132ENST00000322635ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000356132ENST00000322680ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000356132ENST00000351293ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000356132ENST00000372765ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000356132ENST00000394762ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000356132ENST00000423381ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000356132ENST00000444854ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000356132ENST00000472912ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000392669ENST00000305762ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000392669ENST00000322635ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000392669ENST00000322680ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000392669ENST00000351293ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000392669ENST00000372765ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000392669ENST00000394762ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000392669ENST00000423381ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000392669ENST00000444854ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000392669ENST00000472912ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000444328ENST00000305762ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000444328ENST00000322635ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000444328ENST00000322680ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000444328ENST00000351293ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000444328ENST00000372765ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000444328ENST00000394762ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000444328ENST00000423381ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000444328ENST00000444854ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000444328ENST00000472912ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000449406ENST00000305762ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000449406ENST00000322635ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000449406ENST00000322680ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000449406ENST00000351293ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000449406ENST00000372765ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000449406ENST00000394762ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000449406ENST00000423381ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000449406ENST00000444854ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000449406ENST00000472912ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000526727ENST00000305762ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000526727ENST00000322635ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000526727ENST00000322680ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000526727ENST00000351293ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000526727ENST00000372765ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000526727ENST00000394762ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000526727ENST00000423381ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000526727ENST00000444854ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000526727ENST00000472912ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000530591ENST00000305762ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000530591ENST00000322635ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000530591ENST00000322680ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000530591ENST00000351293ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000530591ENST00000372765ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000530591ENST00000394762ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000530591ENST00000423381ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000530591ENST00000444854ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000530591ENST00000472912ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000532243ENST00000305762ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000532243ENST00000322635ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000532243ENST00000322680ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000532243ENST00000351293ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000532243ENST00000372765ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000532243ENST00000394762ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000532243ENST00000423381ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000532243ENST00000444854ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000532243ENST00000472912ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000534083ENST00000305762ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000534083ENST00000322635ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000534083ENST00000322680ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000534083ENST00000351293ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000534083ENST00000372765ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000534083ENST00000394762ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000534083ENST00000423381ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000534083ENST00000444854ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000534083ENST00000472912ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000534457ENST00000305762ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000534457ENST00000322635ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000534457ENST00000322680ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000534457ENST00000351293ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000534457ENST00000372765ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000534457ENST00000394762ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000534457ENST00000423381ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000534457ENST00000444854ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+
intron-intronENST00000534457ENST00000472912ST3GAL4chr11

126275597

+CAMK2Gchr10

75574763

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ST3GAL4-CAMK2G


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ST3GAL4chr11126275594+CAMK2Gchr1075574760+0.9998280.000171954
ST3GAL4chr11126275594+CAMK2Gchr1075574760+0.9998280.000171954

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ST3GAL4-CAMK2G


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:126275597/:75574763)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CAMK2G

Q13555

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. {ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:30184290}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ST3GAL4-CAMK2G


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ST3GAL4-CAMK2G


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ST3GAL4-CAMK2G


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ST3GAL4-CAMK2G


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource