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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ST5-DENND5A (FusionGDB2 ID:86969)

Fusion Gene Summary for ST5-DENND5A

check button Fusion gene summary
Fusion gene informationFusion gene name: ST5-DENND5A
Fusion gene ID: 86969
HgeneTgene
Gene symbol

ST5

DENND5A

Gene ID

6764

23258

Gene nameDENN domain containing 2BDENN domain containing 5A
SynonymsHTS1|ST5|p126EIEE49|RAB6IP1
Cytomap

11p15.4

11p15.4

Type of geneprotein-codingprotein-coding
Descriptionsuppression of tumorigenicity 5 proteinDENN/MADD domain containing 2BheLa tumor suppression 1DENN domain-containing protein 5ADENN/MADD domain containing 5ARAB6 interacting protein 1rab6-interacting protein 1
Modification date2020031320200313
UniProtAcc.

Q6IQ26

Ensembl transtripts involved in fusion geneENST00000313726, ENST00000357665, 
ENST00000526757, ENST00000530438, 
ENST00000534127, ENST00000526099, 
ENST00000530991, ENST00000531237, 
ENST00000534278, 		ENST00000526523, 
ENST00000328194, ENST00000527700, 
ENST00000530044, 
Fusion gene scores* DoF score10 X 11 X 7=77015 X 15 X 6=1350
# samples 1216
** MAII scorelog2(12/770*10)=-2.68182403997375
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1350*10)=-3.07681559705083
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ST5 [Title/Abstract] AND DENND5A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDENND5A(9163487)-ST5(8772272), # samples:1
ST5(8853103)-DENND5A(9171756), # samples:3
Anticipated loss of major functional domain due to fusion event.ST5-DENND5A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ST5-DENND5A seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
ST5-DENND5A seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ST5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DENND5A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-B6-A0X1-01AST5chr11

8772168

-DENND5Achr11

9163655

-
ChimerDB4SKCMTCGA-W3-AA1V-06BST5chr11

8853103

-DENND5Achr11

9171756

-
ChimerDB4SKCMTCGA-W3-AA1V-06BST5chr11

8860857

-DENND5Achr11

9171756

-
ChimerDB4SKCMTCGA-W3-AA1V-06BST5chr11

8892881

-DENND5Achr11

9171756

-


Top

Fusion Gene ORF analysis for ST5-DENND5A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000313726ENST00000526523ST5chr11

8772168

-DENND5Achr11

9163655

-
5CDS-intronENST00000357665ENST00000526523ST5chr11

8772168

-DENND5Achr11

9163655

-
5CDS-intronENST00000526757ENST00000526523ST5chr11

8772168

-DENND5Achr11

9163655

-
5CDS-intronENST00000530438ENST00000526523ST5chr11

8772168

-DENND5Achr11

9163655

-
5CDS-intronENST00000534127ENST00000526523ST5chr11

8772168

-DENND5Achr11

9163655

-
5UTR-3CDSENST00000357665ENST00000328194ST5chr11

8860857

-DENND5Achr11

9171756

-
5UTR-3CDSENST00000357665ENST00000527700ST5chr11

8860857

-DENND5Achr11

9171756

-
5UTR-3CDSENST00000357665ENST00000530044ST5chr11

8860857

-DENND5Achr11

9171756

-
5UTR-3CDSENST00000534127ENST00000328194ST5chr11

8860857

-DENND5Achr11

9171756

-
5UTR-3CDSENST00000534127ENST00000527700ST5chr11

8860857

-DENND5Achr11

9171756

-
5UTR-3CDSENST00000534127ENST00000530044ST5chr11

8860857

-DENND5Achr11

9171756

-
5UTR-intronENST00000357665ENST00000526523ST5chr11

8860857

-DENND5Achr11

9171756

-
5UTR-intronENST00000534127ENST00000526523ST5chr11

8860857

-DENND5Achr11

9171756

-
Frame-shiftENST00000526757ENST00000328194ST5chr11

8772168

-DENND5Achr11

9163655

-
Frame-shiftENST00000526757ENST00000527700ST5chr11

8772168

-DENND5Achr11

9163655

-
Frame-shiftENST00000526757ENST00000530044ST5chr11

8772168

-DENND5Achr11

9163655

-
In-frameENST00000313726ENST00000328194ST5chr11

8772168

-DENND5Achr11

9163655

-
In-frameENST00000313726ENST00000527700ST5chr11

8772168

-DENND5Achr11

9163655

-
In-frameENST00000313726ENST00000530044ST5chr11

8772168

-DENND5Achr11

9163655

-
In-frameENST00000357665ENST00000328194ST5chr11

8772168

-DENND5Achr11

9163655

-
In-frameENST00000357665ENST00000527700ST5chr11

8772168

-DENND5Achr11

9163655

-
In-frameENST00000357665ENST00000530044ST5chr11

8772168

-DENND5Achr11

9163655

-
In-frameENST00000530438ENST00000328194ST5chr11

8772168

-DENND5Achr11

9163655

-
In-frameENST00000530438ENST00000527700ST5chr11

8772168

-DENND5Achr11

9163655

-
In-frameENST00000530438ENST00000530044ST5chr11

8772168

-DENND5Achr11

9163655

-
In-frameENST00000534127ENST00000328194ST5chr11

8772168

-DENND5Achr11

9163655

-
In-frameENST00000534127ENST00000527700ST5chr11

8772168

-DENND5Achr11

9163655

-
In-frameENST00000534127ENST00000530044ST5chr11

8772168

-DENND5Achr11

9163655

-
intron-3CDSENST00000313726ENST00000328194ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000313726ENST00000328194ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-3CDSENST00000313726ENST00000328194ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-3CDSENST00000313726ENST00000527700ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000313726ENST00000527700ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-3CDSENST00000313726ENST00000527700ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-3CDSENST00000313726ENST00000530044ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000313726ENST00000530044ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-3CDSENST00000313726ENST00000530044ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-3CDSENST00000357665ENST00000328194ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000357665ENST00000328194ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-3CDSENST00000357665ENST00000527700ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000357665ENST00000527700ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-3CDSENST00000357665ENST00000530044ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000357665ENST00000530044ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-3CDSENST00000526099ENST00000328194ST5chr11

8772168

-DENND5Achr11

9163655

-
intron-3CDSENST00000526099ENST00000328194ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000526099ENST00000328194ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-3CDSENST00000526099ENST00000328194ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-3CDSENST00000526099ENST00000527700ST5chr11

8772168

-DENND5Achr11

9163655

-
intron-3CDSENST00000526099ENST00000527700ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000526099ENST00000527700ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-3CDSENST00000526099ENST00000527700ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-3CDSENST00000526099ENST00000530044ST5chr11

8772168

-DENND5Achr11

9163655

-
intron-3CDSENST00000526099ENST00000530044ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000526099ENST00000530044ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-3CDSENST00000526099ENST00000530044ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-3CDSENST00000526757ENST00000328194ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000526757ENST00000328194ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-3CDSENST00000526757ENST00000328194ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-3CDSENST00000526757ENST00000527700ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000526757ENST00000527700ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-3CDSENST00000526757ENST00000527700ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-3CDSENST00000526757ENST00000530044ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000526757ENST00000530044ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-3CDSENST00000526757ENST00000530044ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-3CDSENST00000530438ENST00000328194ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000530438ENST00000328194ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-3CDSENST00000530438ENST00000328194ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-3CDSENST00000530438ENST00000527700ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000530438ENST00000527700ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-3CDSENST00000530438ENST00000527700ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-3CDSENST00000530438ENST00000530044ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000530438ENST00000530044ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-3CDSENST00000530438ENST00000530044ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-3CDSENST00000530991ENST00000328194ST5chr11

8772168

-DENND5Achr11

9163655

-
intron-3CDSENST00000530991ENST00000328194ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000530991ENST00000328194ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-3CDSENST00000530991ENST00000328194ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-3CDSENST00000530991ENST00000527700ST5chr11

8772168

-DENND5Achr11

9163655

-
intron-3CDSENST00000530991ENST00000527700ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000530991ENST00000527700ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-3CDSENST00000530991ENST00000527700ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-3CDSENST00000530991ENST00000530044ST5chr11

8772168

-DENND5Achr11

9163655

-
intron-3CDSENST00000530991ENST00000530044ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000530991ENST00000530044ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-3CDSENST00000530991ENST00000530044ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-3CDSENST00000531237ENST00000328194ST5chr11

8772168

-DENND5Achr11

9163655

-
intron-3CDSENST00000531237ENST00000328194ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000531237ENST00000328194ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-3CDSENST00000531237ENST00000328194ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-3CDSENST00000531237ENST00000527700ST5chr11

8772168

-DENND5Achr11

9163655

-
intron-3CDSENST00000531237ENST00000527700ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000531237ENST00000527700ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-3CDSENST00000531237ENST00000527700ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-3CDSENST00000531237ENST00000530044ST5chr11

8772168

-DENND5Achr11

9163655

-
intron-3CDSENST00000531237ENST00000530044ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000531237ENST00000530044ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-3CDSENST00000531237ENST00000530044ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-3CDSENST00000534127ENST00000328194ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000534127ENST00000328194ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-3CDSENST00000534127ENST00000527700ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000534127ENST00000527700ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-3CDSENST00000534127ENST00000530044ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000534127ENST00000530044ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-3CDSENST00000534278ENST00000328194ST5chr11

8772168

-DENND5Achr11

9163655

-
intron-3CDSENST00000534278ENST00000328194ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000534278ENST00000328194ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-3CDSENST00000534278ENST00000328194ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-3CDSENST00000534278ENST00000527700ST5chr11

8772168

-DENND5Achr11

9163655

-
intron-3CDSENST00000534278ENST00000527700ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000534278ENST00000527700ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-3CDSENST00000534278ENST00000527700ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-3CDSENST00000534278ENST00000530044ST5chr11

8772168

-DENND5Achr11

9163655

-
intron-3CDSENST00000534278ENST00000530044ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-3CDSENST00000534278ENST00000530044ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-3CDSENST00000534278ENST00000530044ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-intronENST00000313726ENST00000526523ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-intronENST00000313726ENST00000526523ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-intronENST00000313726ENST00000526523ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-intronENST00000357665ENST00000526523ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-intronENST00000357665ENST00000526523ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-intronENST00000526099ENST00000526523ST5chr11

8772168

-DENND5Achr11

9163655

-
intron-intronENST00000526099ENST00000526523ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-intronENST00000526099ENST00000526523ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-intronENST00000526099ENST00000526523ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-intronENST00000526757ENST00000526523ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-intronENST00000526757ENST00000526523ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-intronENST00000526757ENST00000526523ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-intronENST00000530438ENST00000526523ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-intronENST00000530438ENST00000526523ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-intronENST00000530438ENST00000526523ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-intronENST00000530991ENST00000526523ST5chr11

8772168

-DENND5Achr11

9163655

-
intron-intronENST00000530991ENST00000526523ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-intronENST00000530991ENST00000526523ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-intronENST00000530991ENST00000526523ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-intronENST00000531237ENST00000526523ST5chr11

8772168

-DENND5Achr11

9163655

-
intron-intronENST00000531237ENST00000526523ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-intronENST00000531237ENST00000526523ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-intronENST00000531237ENST00000526523ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-intronENST00000534127ENST00000526523ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-intronENST00000534127ENST00000526523ST5chr11

8892881

-DENND5Achr11

9171756

-
intron-intronENST00000534278ENST00000526523ST5chr11

8772168

-DENND5Achr11

9163655

-
intron-intronENST00000534278ENST00000526523ST5chr11

8853103

-DENND5Achr11

9171756

-
intron-intronENST00000534278ENST00000526523ST5chr11

8860857

-DENND5Achr11

9171756

-
intron-intronENST00000534278ENST00000526523ST5chr11

8892881

-DENND5Achr11

9171756

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000534127ST5chr118772168-ENST00000328194DENND5Achr119163655-16654661267154893
ENST00000534127ST5chr118772168-ENST00000530044DENND5Achr119163655-99746688661191
ENST00000534127ST5chr118772168-ENST00000527700DENND5Achr119163655-98646692064591
ENST00000313726ST5chr118772168-ENST00000328194DENND5Achr119163655-16284291230151193
ENST00000313726ST5chr118772168-ENST00000530044DENND5Achr119163655-96042984957491
ENST00000313726ST5chr118772168-ENST00000527700DENND5Achr119163655-94942988360891
ENST00000357665ST5chr118772168-ENST00000328194DENND5Achr119163655-14392401041132293
ENST00000357665ST5chr118772168-ENST00000530044DENND5Achr119163655-77124066038591
ENST00000357665ST5chr118772168-ENST00000527700DENND5Achr119163655-76024069441991
ENST00000530438ST5chr118772168-ENST00000328194DENND5Achr119163655-18046053740125
ENST00000530438ST5chr118772168-ENST00000530044DENND5Achr119163655-1136605102575091
ENST00000530438ST5chr118772168-ENST00000527700DENND5Achr119163655-11256053740125

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000534127ENST00000328194ST5chr118772168-DENND5Achr119163655-0.555499260.44450068
ENST00000534127ENST00000530044ST5chr118772168-DENND5Achr119163655-0.299093630.70090634
ENST00000534127ENST00000527700ST5chr118772168-DENND5Achr119163655-0.121675770.8783243
ENST00000313726ENST00000328194ST5chr118772168-DENND5Achr119163655-0.682719350.3172807
ENST00000313726ENST00000530044ST5chr118772168-DENND5Achr119163655-0.45062840.5493716
ENST00000313726ENST00000527700ST5chr118772168-DENND5Achr119163655-0.158943180.8410568
ENST00000357665ENST00000328194ST5chr118772168-DENND5Achr119163655-0.691582140.3084178
ENST00000357665ENST00000530044ST5chr118772168-DENND5Achr119163655-0.2166190.783381
ENST00000357665ENST00000527700ST5chr118772168-DENND5Achr119163655-0.094059610.9059404
ENST00000530438ENST00000328194ST5chr118772168-DENND5Achr119163655-0.93229190.06770802
ENST00000530438ENST00000530044ST5chr118772168-DENND5Achr119163655-0.5154750.48452502
ENST00000530438ENST00000527700ST5chr118772168-DENND5Achr119163655-0.273805860.7261941

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Fusion Genomic Features for ST5-DENND5A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ST5-DENND5A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:9163487/chr11:8772272)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DENND5A

Q6IQ26

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:G3V7Q0, ECO:0000269|PubMed:20937701}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneST5chr11:8772168chr11:9163655ENST00000313726-22033_93261138.0Compositional biasNote=Pro-rich
HgeneST5chr11:8772168chr11:9163655ENST00000313726-220350_434261138.0Compositional biasNote=Pro-rich
HgeneST5chr11:8772168chr11:9163655ENST00000357665-32133_93261138.0Compositional biasNote=Pro-rich
HgeneST5chr11:8772168chr11:9163655ENST00000357665-321350_434261138.0Compositional biasNote=Pro-rich
HgeneST5chr11:8772168chr11:9163655ENST00000526757-21933_9326718.0Compositional biasNote=Pro-rich
HgeneST5chr11:8772168chr11:9163655ENST00000526757-219350_43426718.0Compositional biasNote=Pro-rich
HgeneST5chr11:8772168chr11:9163655ENST00000530438-21933_9326718.0Compositional biasNote=Pro-rich
HgeneST5chr11:8772168chr11:9163655ENST00000530438-219350_43426718.0Compositional biasNote=Pro-rich
HgeneST5chr11:8772168chr11:9163655ENST00000530991-11733_930610.0Compositional biasNote=Pro-rich
HgeneST5chr11:8772168chr11:9163655ENST00000530991-117350_4340610.0Compositional biasNote=Pro-rich
HgeneST5chr11:8772168chr11:9163655ENST00000534127-52333_93261138.0Compositional biasNote=Pro-rich
HgeneST5chr11:8772168chr11:9163655ENST00000534127-523350_434261138.0Compositional biasNote=Pro-rich
HgeneST5chr11:8772168chr11:9163655ENST00000313726-2201003_1096261138.0DomaindDENN
HgeneST5chr11:8772168chr11:9163655ENST00000313726-220698_846261138.0DomainuDENN
HgeneST5chr11:8772168chr11:9163655ENST00000313726-220868_1001261138.0DomaincDENN
HgeneST5chr11:8772168chr11:9163655ENST00000357665-3211003_1096261138.0DomaindDENN
HgeneST5chr11:8772168chr11:9163655ENST00000357665-321698_846261138.0DomainuDENN
HgeneST5chr11:8772168chr11:9163655ENST00000357665-321868_1001261138.0DomaincDENN
HgeneST5chr11:8772168chr11:9163655ENST00000526757-2191003_109626718.0DomaindDENN
HgeneST5chr11:8772168chr11:9163655ENST00000526757-219698_84626718.0DomainuDENN
HgeneST5chr11:8772168chr11:9163655ENST00000526757-219868_100126718.0DomaincDENN
HgeneST5chr11:8772168chr11:9163655ENST00000530438-2191003_109626718.0DomaindDENN
HgeneST5chr11:8772168chr11:9163655ENST00000530438-219698_84626718.0DomainuDENN
HgeneST5chr11:8772168chr11:9163655ENST00000530438-219868_100126718.0DomaincDENN
HgeneST5chr11:8772168chr11:9163655ENST00000530991-1171003_10960610.0DomaindDENN
HgeneST5chr11:8772168chr11:9163655ENST00000530991-117698_8460610.0DomainuDENN
HgeneST5chr11:8772168chr11:9163655ENST00000530991-117868_10010610.0DomaincDENN
HgeneST5chr11:8772168chr11:9163655ENST00000534127-5231003_1096261138.0DomaindDENN
HgeneST5chr11:8772168chr11:9163655ENST00000534127-523698_846261138.0DomainuDENN
HgeneST5chr11:8772168chr11:9163655ENST00000534127-523868_1001261138.0DomaincDENN
TgeneDENND5Achr11:8772168chr11:9163655ENST0000032819420233_911701288.0Compositional biasNote=Poly-Gly
TgeneDENND5Achr11:8772168chr11:9163655ENST000003281942023593_59811701288.0Compositional biasNote=Poly-Asp
TgeneDENND5Achr11:8772168chr11:9163655ENST0000053004420233_911701242.0Compositional biasNote=Poly-Gly
TgeneDENND5Achr11:8772168chr11:9163655ENST000005300442023593_59811701242.0Compositional biasNote=Poly-Asp
TgeneDENND5Achr11:8772168chr11:9163655ENST0000032819420231134_128211701288.0DomainRUN 2
TgeneDENND5Achr11:8772168chr11:9163655ENST000003281942023278_41411701288.0DomaincDENN
TgeneDENND5Achr11:8772168chr11:9163655ENST000003281942023416_59811701288.0DomaindDENN
TgeneDENND5Achr11:8772168chr11:9163655ENST00000328194202357_25911701288.0DomainuDENN
TgeneDENND5Achr11:8772168chr11:9163655ENST000003281942023787_95011701288.0DomainRUN 1
TgeneDENND5Achr11:8772168chr11:9163655ENST000003281942023954_106211701288.0DomainPLAT
TgeneDENND5Achr11:8772168chr11:9163655ENST0000053004420231134_128211701242.0DomainRUN 2
TgeneDENND5Achr11:8772168chr11:9163655ENST000005300442023278_41411701242.0DomaincDENN
TgeneDENND5Achr11:8772168chr11:9163655ENST000005300442023416_59811701242.0DomaindDENN
TgeneDENND5Achr11:8772168chr11:9163655ENST00000530044202357_25911701242.0DomainuDENN
TgeneDENND5Achr11:8772168chr11:9163655ENST000005300442023787_95011701242.0DomainRUN 1
TgeneDENND5Achr11:8772168chr11:9163655ENST000005300442023954_106211701242.0DomainPLAT


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Fusion Gene Sequence for ST5-DENND5A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>86969_86969_1_ST5-DENND5A_ST5_chr11_8772168_ENST00000313726_DENND5A_chr11_9163655_ENST00000328194_length(transcript)=1628nt_BP=429nt
GAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGACAGTGAGAAAGAAAGAAAAAGAGAGCGCCCTTGTGCACGCGCTAGGCCAAGAGCGC
GCCGCTGTGCGCGCGCCCGCCTAGCGAGGACAGGGTCTCCATGACAACCGGCCTGGCCGGCTAGCAGTGCTCTGCTCACTTGGCTGCGAG
GAGCGCCACGAAAGGTCAGAGGAAGGAGCTGTGGGAAGCTCGCAGCAGGTATCGGAGCTTAAGCCAGTGGATTTGGGGGCCCTGGGCTCC
CTAGCCGGCTGCGGTGTGAGAATGGAGTGGGCAGGAAAGCAGCGGGACTTTCAGGGCTCTGGGTTTGCAGAGAGCCGAAATGACCATGAC
TGCCAACAAGAATTCCAGCATCACCCACGGAGCTGGTGGCACTAAAGCCCCTCGGGGGACTCTGAGCAGAAAAAGCACAAACCTATTATG
AGACATTAGAGAAGAATGAAGTAGTCCCTGAGGAAAACTGGCATACAAGAGCCCGGAACTTCTGCCGATTTGTCACTGCAATCAACAATA
CTCCCCGGAACATCGGCAAGGATGGCAAGTTTCAGATGCTGGTGTGCTTGGGAGCCAGAGATCACCTCCTACACCACTGGATTGCCCTGC
TGGCTGACTGCCCCATCACTGCACACATGTATGAGGATGTGGCACTGATCAAAGACCATACACTTGTCAATTCCTTGATTCGTGTGCTGC
AGACATTGCAGGAGTTCAACATCACGCTGGAGACGTCCCTTGTCAAGGGCATCGACATCTGACCTCCCAGCACCAGCCAGCAGCAGGACT
GAGAAAGACTCACCCTGCAGCTCTGACCTTTTTTCCCAAAGGGACTTAAGCGATTGTGCAGGAGTAGGAGACAAAATGTACACTCACTGT
AAAAAGAAAACTAGAGGATTTTTGGAATAAATAATCTATTTTAGAGTTTATTTGCTGATTTGCTTTTTACACACTTTCATGTGAAAGAGT
GATAGGGAGAGGGAGCGAGGCTGGTGCCGCTTATTTTGAAGCTGGTGCCCTCCCTCGCCGTGGCCACATGCTGGAAGCCTGAGGCCTCCC
TGGACTGAGCCTGTGGCACTGCGTGCGGGACAGTTATGTTTCCTTGCCCCGTCGCATTAATGAGGCCCTTCCACATCATTTTTAAACTAA
TGTTTTTCTATATTAACATTATTATGGATATTTGGCTTTCATAGGCCACACACAGGTGTGCTGCGCGGGAAGCCCCATGCTCCAATCAAA
GGGATTTTTAGTAGTGCCTCTAAGCAAGCACCGATGAGTCAGTCCCACGTATTTTCTTTTTTGTCAGTATTGTTTGGGAAGGAGACATGC
CGGGATGTGTCATCGTGCCAAATACCACATTTCCTGTTGGCACAGTTTCACAGAAGTAAACATAAGCATGTTTTAACAGGTTTTTCTTTT
CTTTTTTCTTTTTTAAAATGTTTTATTTATTTAACCCGCCATTGTGTGTTTTTAAGTATTTTCTTTTTTTAAGGAAAGGAAAAGCTTGTC
ACAATCTAACTGGCTATGTTATTATTATTAAATTTATGTTTTGCAACTTAGAAACCAGCTACAGTATGGCCCACTTAATAAAACACCTGA

>86969_86969_1_ST5-DENND5A_ST5_chr11_8772168_ENST00000313726_DENND5A_chr11_9163655_ENST00000328194_length(amino acids)=93AA_BP=
MRGKPHAPIKGIFSSASKQAPMSQSHVFSFLSVLFGKETCRDVSSCQIPHFLLAQFHRSKHKHVLTGFSFLFSFLKCFIYLTRHCVFLSI

--------------------------------------------------------------
>86969_86969_2_ST5-DENND5A_ST5_chr11_8772168_ENST00000313726_DENND5A_chr11_9163655_ENST00000527700_length(transcript)=949nt_BP=429nt
GAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGACAGTGAGAAAGAAAGAAAAAGAGAGCGCCCTTGTGCACGCGCTAGGCCAAGAGCGC
GCCGCTGTGCGCGCGCCCGCCTAGCGAGGACAGGGTCTCCATGACAACCGGCCTGGCCGGCTAGCAGTGCTCTGCTCACTTGGCTGCGAG
GAGCGCCACGAAAGGTCAGAGGAAGGAGCTGTGGGAAGCTCGCAGCAGGTATCGGAGCTTAAGCCAGTGGATTTGGGGGCCCTGGGCTCC
CTAGCCGGCTGCGGTGTGAGAATGGAGTGGGCAGGAAAGCAGCGGGACTTTCAGGGCTCTGGGTTTGCAGAGAGCCGAAATGACCATGAC
TGCCAACAAGAATTCCAGCATCACCCACGGAGCTGGTGGCACTAAAGCCCCTCGGGGGACTCTGAGCAGAAAAAGCACAAACCTATTATG
AGACATTAGAGAAGAATGAAGTAGTCCCTGAGGAAAACTGGCATACAAGAGCCCGGAACTTCTGCCGATTTGTCACTGCAATCAACAATA
CTCCCCGGAACATCGGCAAGGATGGCAAGTTTCAGATGCTGGTGTGCTTGGGAGCCAGAGATCACCTCCTACACCACTGGATTGCCCTGC
TGGCTGACTGCCCCATCACTGCACACATGTATGAGGATGTGGCACTGATCAAAGACCATACACTTGTCAATTCCTTGATTCGTGTGCTGC
AGACATTGCAGGAGTTCAACATCACGCTGGAGACGTCCCTTGTCAAGGGCATCGACATCTGACCTCCCAGCACCAGCCAGCAGCAGGACT
GAGAAAGACTCACCCTGCAGCTCTGACCTTTTTTCCCAAAGGGACTTAAGCGATTGTGCAGGAGTAGGAGACAAAATGTACACTCACTGT

>86969_86969_2_ST5-DENND5A_ST5_chr11_8772168_ENST00000313726_DENND5A_chr11_9163655_ENST00000527700_length(amino acids)=91AA_BP=
MSPTPAQSLKSLWEKRSELQGESFSVLLLAGAGRSDVDALDKGRLQRDVELLQCLQHTNQGIDKCMVFDQCHILIHVCSDGAVSQQGNPV

--------------------------------------------------------------
>86969_86969_3_ST5-DENND5A_ST5_chr11_8772168_ENST00000313726_DENND5A_chr11_9163655_ENST00000530044_length(transcript)=960nt_BP=429nt
GAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGACAGTGAGAAAGAAAGAAAAAGAGAGCGCCCTTGTGCACGCGCTAGGCCAAGAGCGC
GCCGCTGTGCGCGCGCCCGCCTAGCGAGGACAGGGTCTCCATGACAACCGGCCTGGCCGGCTAGCAGTGCTCTGCTCACTTGGCTGCGAG
GAGCGCCACGAAAGGTCAGAGGAAGGAGCTGTGGGAAGCTCGCAGCAGGTATCGGAGCTTAAGCCAGTGGATTTGGGGGCCCTGGGCTCC
CTAGCCGGCTGCGGTGTGAGAATGGAGTGGGCAGGAAAGCAGCGGGACTTTCAGGGCTCTGGGTTTGCAGAGAGCCGAAATGACCATGAC
TGCCAACAAGAATTCCAGCATCACCCACGGAGCTGGTGGCACTAAAGCCCCTCGGGGGACTCTGAGCAGAAAAAGCACAAACCTATTATG
AGACATTAGAGAAGAATGAAGTAGTCCCTGAGGAAAACTGGCATACAAGAGCCCGGAACTTCTGCCGATTTGTCACTGCAATCAACAATA
CTCCCCGGAACATCGGCAAGGATGAGATCACCTCCTACACCACTGGATTGCCCTGCTGGCTGACTGCCCCATCACTGCACACATGTATGA
GGATGTGGCACTGATCAAAGACCATACACTTGTCAATTCCTTGATTCGTGTGCTGCAGACATTGCAGGAGTTCAACATCACGCTGGAGAC
GTCCCTTGTCAAGGGCATCGACATCTGACCTCCCAGCACCAGCCAGCAGCAGGACTGAGAAAGACTCACCCTGCAGCTCTGACCTTTTTT
CCCAAAGGGACTTAAGCGATTGTGCAGGAGTAGGAGACAAAATGTACACTCACTGTAAAAAGAAAACTAGAGGATTTTTGGAATAAATAA

>86969_86969_3_ST5-DENND5A_ST5_chr11_8772168_ENST00000313726_DENND5A_chr11_9163655_ENST00000530044_length(amino acids)=91AA_BP=
MSPTPAQSLKSLWEKRSELQGESFSVLLLAGAGRSDVDALDKGRLQRDVELLQCLQHTNQGIDKCMVFDQCHILIHVCSDGAVSQQGNPV

--------------------------------------------------------------
>86969_86969_4_ST5-DENND5A_ST5_chr11_8772168_ENST00000357665_DENND5A_chr11_9163655_ENST00000328194_length(transcript)=1439nt_BP=240nt
CACAGATTTCACACCCTTTGGAGAGTTTCTTTCTTGGATAATTCAGGAAGATGAGAGACTGCTTAGGCGCCACCACTAGTACCATGAGTC
CCTGCACTGGTTAAAGCCATCGCCACAACCTGGACAGGCAGCAAGGGCTCTGGGTTTGCAGAGAGCCGAAATGACCATGACTGCCAACAA
GAATTCCAGCATCACCCACGGAGCTGGTGGCACTAAAGCCCCTCGGGGGACTCTGAGCAGAAAAAGCACAAACCTATTATGAGACATTAG
AGAAGAATGAAGTAGTCCCTGAGGAAAACTGGCATACAAGAGCCCGGAACTTCTGCCGATTTGTCACTGCAATCAACAATACTCCCCGGA
ACATCGGCAAGGATGGCAAGTTTCAGATGCTGGTGTGCTTGGGAGCCAGAGATCACCTCCTACACCACTGGATTGCCCTGCTGGCTGACT
GCCCCATCACTGCACACATGTATGAGGATGTGGCACTGATCAAAGACCATACACTTGTCAATTCCTTGATTCGTGTGCTGCAGACATTGC
AGGAGTTCAACATCACGCTGGAGACGTCCCTTGTCAAGGGCATCGACATCTGACCTCCCAGCACCAGCCAGCAGCAGGACTGAGAAAGAC
TCACCCTGCAGCTCTGACCTTTTTTCCCAAAGGGACTTAAGCGATTGTGCAGGAGTAGGAGACAAAATGTACACTCACTGTAAAAAGAAA
ACTAGAGGATTTTTGGAATAAATAATCTATTTTAGAGTTTATTTGCTGATTTGCTTTTTACACACTTTCATGTGAAAGAGTGATAGGGAG
AGGGAGCGAGGCTGGTGCCGCTTATTTTGAAGCTGGTGCCCTCCCTCGCCGTGGCCACATGCTGGAAGCCTGAGGCCTCCCTGGACTGAG
CCTGTGGCACTGCGTGCGGGACAGTTATGTTTCCTTGCCCCGTCGCATTAATGAGGCCCTTCCACATCATTTTTAAACTAATGTTTTTCT
ATATTAACATTATTATGGATATTTGGCTTTCATAGGCCACACACAGGTGTGCTGCGCGGGAAGCCCCATGCTCCAATCAAAGGGATTTTT
AGTAGTGCCTCTAAGCAAGCACCGATGAGTCAGTCCCACGTATTTTCTTTTTTGTCAGTATTGTTTGGGAAGGAGACATGCCGGGATGTG
TCATCGTGCCAAATACCACATTTCCTGTTGGCACAGTTTCACAGAAGTAAACATAAGCATGTTTTAACAGGTTTTTCTTTTCTTTTTTCT
TTTTTAAAATGTTTTATTTATTTAACCCGCCATTGTGTGTTTTTAAGTATTTTCTTTTTTTAAGGAAAGGAAAAGCTTGTCACAATCTAA

>86969_86969_4_ST5-DENND5A_ST5_chr11_8772168_ENST00000357665_DENND5A_chr11_9163655_ENST00000328194_length(amino acids)=93AA_BP=
MRGKPHAPIKGIFSSASKQAPMSQSHVFSFLSVLFGKETCRDVSSCQIPHFLLAQFHRSKHKHVLTGFSFLFSFLKCFIYLTRHCVFLSI

--------------------------------------------------------------
>86969_86969_5_ST5-DENND5A_ST5_chr11_8772168_ENST00000357665_DENND5A_chr11_9163655_ENST00000527700_length(transcript)=760nt_BP=240nt
CACAGATTTCACACCCTTTGGAGAGTTTCTTTCTTGGATAATTCAGGAAGATGAGAGACTGCTTAGGCGCCACCACTAGTACCATGAGTC
CCTGCACTGGTTAAAGCCATCGCCACAACCTGGACAGGCAGCAAGGGCTCTGGGTTTGCAGAGAGCCGAAATGACCATGACTGCCAACAA
GAATTCCAGCATCACCCACGGAGCTGGTGGCACTAAAGCCCCTCGGGGGACTCTGAGCAGAAAAAGCACAAACCTATTATGAGACATTAG
AGAAGAATGAAGTAGTCCCTGAGGAAAACTGGCATACAAGAGCCCGGAACTTCTGCCGATTTGTCACTGCAATCAACAATACTCCCCGGA
ACATCGGCAAGGATGGCAAGTTTCAGATGCTGGTGTGCTTGGGAGCCAGAGATCACCTCCTACACCACTGGATTGCCCTGCTGGCTGACT
GCCCCATCACTGCACACATGTATGAGGATGTGGCACTGATCAAAGACCATACACTTGTCAATTCCTTGATTCGTGTGCTGCAGACATTGC
AGGAGTTCAACATCACGCTGGAGACGTCCCTTGTCAAGGGCATCGACATCTGACCTCCCAGCACCAGCCAGCAGCAGGACTGAGAAAGAC
TCACCCTGCAGCTCTGACCTTTTTTCCCAAAGGGACTTAAGCGATTGTGCAGGAGTAGGAGACAAAATGTACACTCACTGTAAAAAGAAA

>86969_86969_5_ST5-DENND5A_ST5_chr11_8772168_ENST00000357665_DENND5A_chr11_9163655_ENST00000527700_length(amino acids)=91AA_BP=
MSPTPAQSLKSLWEKRSELQGESFSVLLLAGAGRSDVDALDKGRLQRDVELLQCLQHTNQGIDKCMVFDQCHILIHVCSDGAVSQQGNPV

--------------------------------------------------------------
>86969_86969_6_ST5-DENND5A_ST5_chr11_8772168_ENST00000357665_DENND5A_chr11_9163655_ENST00000530044_length(transcript)=771nt_BP=240nt
CACAGATTTCACACCCTTTGGAGAGTTTCTTTCTTGGATAATTCAGGAAGATGAGAGACTGCTTAGGCGCCACCACTAGTACCATGAGTC
CCTGCACTGGTTAAAGCCATCGCCACAACCTGGACAGGCAGCAAGGGCTCTGGGTTTGCAGAGAGCCGAAATGACCATGACTGCCAACAA
GAATTCCAGCATCACCCACGGAGCTGGTGGCACTAAAGCCCCTCGGGGGACTCTGAGCAGAAAAAGCACAAACCTATTATGAGACATTAG
AGAAGAATGAAGTAGTCCCTGAGGAAAACTGGCATACAAGAGCCCGGAACTTCTGCCGATTTGTCACTGCAATCAACAATACTCCCCGGA
ACATCGGCAAGGATGAGATCACCTCCTACACCACTGGATTGCCCTGCTGGCTGACTGCCCCATCACTGCACACATGTATGAGGATGTGGC
ACTGATCAAAGACCATACACTTGTCAATTCCTTGATTCGTGTGCTGCAGACATTGCAGGAGTTCAACATCACGCTGGAGACGTCCCTTGT
CAAGGGCATCGACATCTGACCTCCCAGCACCAGCCAGCAGCAGGACTGAGAAAGACTCACCCTGCAGCTCTGACCTTTTTTCCCAAAGGG
ACTTAAGCGATTGTGCAGGAGTAGGAGACAAAATGTACACTCACTGTAAAAAGAAAACTAGAGGATTTTTGGAATAAATAATCTATTTTA

>86969_86969_6_ST5-DENND5A_ST5_chr11_8772168_ENST00000357665_DENND5A_chr11_9163655_ENST00000530044_length(amino acids)=91AA_BP=
MSPTPAQSLKSLWEKRSELQGESFSVLLLAGAGRSDVDALDKGRLQRDVELLQCLQHTNQGIDKCMVFDQCHILIHVCSDGAVSQQGNPV

--------------------------------------------------------------
>86969_86969_7_ST5-DENND5A_ST5_chr11_8772168_ENST00000530438_DENND5A_chr11_9163655_ENST00000328194_length(transcript)=1804nt_BP=605nt
GAAGAAAACAAGTCCACTCACTGTCTTCTCCCTTCTCCCCTCTGAGCTGTTCAAGCAAGTTCCCAGGAGCAGTTCAGAGCCCCTGTTGGA
CTGGAAGGGAGGTAGGAGGAGTGGAATGCATGCAAAAACCGAGCTGATCAAAAGACAGTGCTGTTTCATGGAAGCCTCCCAGAACTGAGA
GAGAGAGAGAGAGAGAGAGAGAGAGAGAGACAGTGAGAAAGAAAGAAAAAGAGAGCGCCCTTGTGCACGCGCTAGGCCAAGAGCGCGCCG
CTGTGCGCGCGCCCGCCTAGCGAGGACAGGGTCTCCATGACAACCGGCCTGGCCGGCTAGCAGTGCTCTGCTCACTTGGCTGCGAGGAGC
GCCACGAAAGGTCAGAGGAAGGAGCTGTGGGAAGCTCGCAGCAGGTATCGGAGCTTAAGCCAGTGGATTTGGGGGCCCTGGGCTCCCTAG
CCGGCTGCGGTGTGAGAATGGAGTGGGCAGGAAAGCAGCGGGACTTTCAGGGCTCTGGGTTTGCAGAGAGCCGAAATGACCATGACTGCC
AACAAGAATTCCAGCATCACCCACGGAGCTGGTGGCACTAAAGCCCCTCGGGGGACTCTGAGCAGAAAAAGCACAAACCTATTATGAGAC
ATTAGAGAAGAATGAAGTAGTCCCTGAGGAAAACTGGCATACAAGAGCCCGGAACTTCTGCCGATTTGTCACTGCAATCAACAATACTCC
CCGGAACATCGGCAAGGATGGCAAGTTTCAGATGCTGGTGTGCTTGGGAGCCAGAGATCACCTCCTACACCACTGGATTGCCCTGCTGGC
TGACTGCCCCATCACTGCACACATGTATGAGGATGTGGCACTGATCAAAGACCATACACTTGTCAATTCCTTGATTCGTGTGCTGCAGAC
ATTGCAGGAGTTCAACATCACGCTGGAGACGTCCCTTGTCAAGGGCATCGACATCTGACCTCCCAGCACCAGCCAGCAGCAGGACTGAGA
AAGACTCACCCTGCAGCTCTGACCTTTTTTCCCAAAGGGACTTAAGCGATTGTGCAGGAGTAGGAGACAAAATGTACACTCACTGTAAAA
AGAAAACTAGAGGATTTTTGGAATAAATAATCTATTTTAGAGTTTATTTGCTGATTTGCTTTTTACACACTTTCATGTGAAAGAGTGATA
GGGAGAGGGAGCGAGGCTGGTGCCGCTTATTTTGAAGCTGGTGCCCTCCCTCGCCGTGGCCACATGCTGGAAGCCTGAGGCCTCCCTGGA
CTGAGCCTGTGGCACTGCGTGCGGGACAGTTATGTTTCCTTGCCCCGTCGCATTAATGAGGCCCTTCCACATCATTTTTAAACTAATGTT
TTTCTATATTAACATTATTATGGATATTTGGCTTTCATAGGCCACACACAGGTGTGCTGCGCGGGAAGCCCCATGCTCCAATCAAAGGGA
TTTTTAGTAGTGCCTCTAAGCAAGCACCGATGAGTCAGTCCCACGTATTTTCTTTTTTGTCAGTATTGTTTGGGAAGGAGACATGCCGGG
ATGTGTCATCGTGCCAAATACCACATTTCCTGTTGGCACAGTTTCACAGAAGTAAACATAAGCATGTTTTAACAGGTTTTTCTTTTCTTT
TTTCTTTTTTAAAATGTTTTATTTATTTAACCCGCCATTGTGTGTTTTTAAGTATTTTCTTTTTTTAAGGAAAGGAAAAGCTTGTCACAA
TCTAACTGGCTATGTTATTATTATTAAATTTATGTTTTGCAACTTAGAAACCAGCTACAGTATGGCCCACTTAATAAAACACCTGAAACA

>86969_86969_7_ST5-DENND5A_ST5_chr11_8772168_ENST00000530438_DENND5A_chr11_9163655_ENST00000328194_length(amino acids)=125AA_BP=
MTFRGAPRSQVSRALLAGQAGCHGDPVLARRARAQRRALGLARAQGRSLFLSFSLSLSLSLSLSLSQFWEASMKQHCLLISSVFACIPLL

--------------------------------------------------------------
>86969_86969_8_ST5-DENND5A_ST5_chr11_8772168_ENST00000530438_DENND5A_chr11_9163655_ENST00000527700_length(transcript)=1125nt_BP=605nt
GAAGAAAACAAGTCCACTCACTGTCTTCTCCCTTCTCCCCTCTGAGCTGTTCAAGCAAGTTCCCAGGAGCAGTTCAGAGCCCCTGTTGGA
CTGGAAGGGAGGTAGGAGGAGTGGAATGCATGCAAAAACCGAGCTGATCAAAAGACAGTGCTGTTTCATGGAAGCCTCCCAGAACTGAGA
GAGAGAGAGAGAGAGAGAGAGAGAGAGAGACAGTGAGAAAGAAAGAAAAAGAGAGCGCCCTTGTGCACGCGCTAGGCCAAGAGCGCGCCG
CTGTGCGCGCGCCCGCCTAGCGAGGACAGGGTCTCCATGACAACCGGCCTGGCCGGCTAGCAGTGCTCTGCTCACTTGGCTGCGAGGAGC
GCCACGAAAGGTCAGAGGAAGGAGCTGTGGGAAGCTCGCAGCAGGTATCGGAGCTTAAGCCAGTGGATTTGGGGGCCCTGGGCTCCCTAG
CCGGCTGCGGTGTGAGAATGGAGTGGGCAGGAAAGCAGCGGGACTTTCAGGGCTCTGGGTTTGCAGAGAGCCGAAATGACCATGACTGCC
AACAAGAATTCCAGCATCACCCACGGAGCTGGTGGCACTAAAGCCCCTCGGGGGACTCTGAGCAGAAAAAGCACAAACCTATTATGAGAC
ATTAGAGAAGAATGAAGTAGTCCCTGAGGAAAACTGGCATACAAGAGCCCGGAACTTCTGCCGATTTGTCACTGCAATCAACAATACTCC
CCGGAACATCGGCAAGGATGGCAAGTTTCAGATGCTGGTGTGCTTGGGAGCCAGAGATCACCTCCTACACCACTGGATTGCCCTGCTGGC
TGACTGCCCCATCACTGCACACATGTATGAGGATGTGGCACTGATCAAAGACCATACACTTGTCAATTCCTTGATTCGTGTGCTGCAGAC
ATTGCAGGAGTTCAACATCACGCTGGAGACGTCCCTTGTCAAGGGCATCGACATCTGACCTCCCAGCACCAGCCAGCAGCAGGACTGAGA
AAGACTCACCCTGCAGCTCTGACCTTTTTTCCCAAAGGGACTTAAGCGATTGTGCAGGAGTAGGAGACAAAATGTACACTCACTGTAAAA

>86969_86969_8_ST5-DENND5A_ST5_chr11_8772168_ENST00000530438_DENND5A_chr11_9163655_ENST00000527700_length(amino acids)=125AA_BP=
MTFRGAPRSQVSRALLAGQAGCHGDPVLARRARAQRRALGLARAQGRSLFLSFSLSLSLSLSLSLSQFWEASMKQHCLLISSVFACIPLL

--------------------------------------------------------------
>86969_86969_9_ST5-DENND5A_ST5_chr11_8772168_ENST00000530438_DENND5A_chr11_9163655_ENST00000530044_length(transcript)=1136nt_BP=605nt
GAAGAAAACAAGTCCACTCACTGTCTTCTCCCTTCTCCCCTCTGAGCTGTTCAAGCAAGTTCCCAGGAGCAGTTCAGAGCCCCTGTTGGA
CTGGAAGGGAGGTAGGAGGAGTGGAATGCATGCAAAAACCGAGCTGATCAAAAGACAGTGCTGTTTCATGGAAGCCTCCCAGAACTGAGA
GAGAGAGAGAGAGAGAGAGAGAGAGAGAGACAGTGAGAAAGAAAGAAAAAGAGAGCGCCCTTGTGCACGCGCTAGGCCAAGAGCGCGCCG
CTGTGCGCGCGCCCGCCTAGCGAGGACAGGGTCTCCATGACAACCGGCCTGGCCGGCTAGCAGTGCTCTGCTCACTTGGCTGCGAGGAGC
GCCACGAAAGGTCAGAGGAAGGAGCTGTGGGAAGCTCGCAGCAGGTATCGGAGCTTAAGCCAGTGGATTTGGGGGCCCTGGGCTCCCTAG
CCGGCTGCGGTGTGAGAATGGAGTGGGCAGGAAAGCAGCGGGACTTTCAGGGCTCTGGGTTTGCAGAGAGCCGAAATGACCATGACTGCC
AACAAGAATTCCAGCATCACCCACGGAGCTGGTGGCACTAAAGCCCCTCGGGGGACTCTGAGCAGAAAAAGCACAAACCTATTATGAGAC
ATTAGAGAAGAATGAAGTAGTCCCTGAGGAAAACTGGCATACAAGAGCCCGGAACTTCTGCCGATTTGTCACTGCAATCAACAATACTCC
CCGGAACATCGGCAAGGATGAGATCACCTCCTACACCACTGGATTGCCCTGCTGGCTGACTGCCCCATCACTGCACACATGTATGAGGAT
GTGGCACTGATCAAAGACCATACACTTGTCAATTCCTTGATTCGTGTGCTGCAGACATTGCAGGAGTTCAACATCACGCTGGAGACGTCC
CTTGTCAAGGGCATCGACATCTGACCTCCCAGCACCAGCCAGCAGCAGGACTGAGAAAGACTCACCCTGCAGCTCTGACCTTTTTTCCCA
AAGGGACTTAAGCGATTGTGCAGGAGTAGGAGACAAAATGTACACTCACTGTAAAAAGAAAACTAGAGGATTTTTGGAATAAATAATCTA

>86969_86969_9_ST5-DENND5A_ST5_chr11_8772168_ENST00000530438_DENND5A_chr11_9163655_ENST00000530044_length(amino acids)=91AA_BP=
MSPTPAQSLKSLWEKRSELQGESFSVLLLAGAGRSDVDALDKGRLQRDVELLQCLQHTNQGIDKCMVFDQCHILIHVCSDGAVSQQGNPV

--------------------------------------------------------------
>86969_86969_10_ST5-DENND5A_ST5_chr11_8772168_ENST00000534127_DENND5A_chr11_9163655_ENST00000328194_length(transcript)=1665nt_BP=466nt
GGGGGTCGGGGGTCGGGGGCTGGGGGCTGAGGACTGAGTCGAGCCAGCAGCCCAGGGCATCTGTCCACGCTGTCAGAGGAGCCTCTGGGC
GTGGGGCTGGCCCTTAGAGGGCTACTGCGCTGCTTAACTTGCCTTTCACAGAAAACCACTGGAGGAGATACTCACAAAAATGAAGGGGAA
GAACAGGAAACAGGAAGACATGAGATGAAGGAAACAGGAGATTCAACATGGATTTCACACCCTTTGGAGAGTTTCTTTCTTGGATAATTC
AGGAAGATGAGAGACTGCTTAGGCGCCACCACTAGTACCATGAGTCCCTGCACTGGTTAAAGCCATCGCCACAACCTGGACAGGCAGCAA
GGGCTCTGGGTTTGCAGAGAGCCGAAATGACCATGACTGCCAACAAGAATTCCAGCATCACCCACGGAGCTGGTGGCACTAAAGCCCCTC
GGGGGACTCTGAGCAGAAAAAGCACAAACCTATTATGAGACATTAGAGAAGAATGAAGTAGTCCCTGAGGAAAACTGGCATACAAGAGCC
CGGAACTTCTGCCGATTTGTCACTGCAATCAACAATACTCCCCGGAACATCGGCAAGGATGGCAAGTTTCAGATGCTGGTGTGCTTGGGA
GCCAGAGATCACCTCCTACACCACTGGATTGCCCTGCTGGCTGACTGCCCCATCACTGCACACATGTATGAGGATGTGGCACTGATCAAA
GACCATACACTTGTCAATTCCTTGATTCGTGTGCTGCAGACATTGCAGGAGTTCAACATCACGCTGGAGACGTCCCTTGTCAAGGGCATC
GACATCTGACCTCCCAGCACCAGCCAGCAGCAGGACTGAGAAAGACTCACCCTGCAGCTCTGACCTTTTTTCCCAAAGGGACTTAAGCGA
TTGTGCAGGAGTAGGAGACAAAATGTACACTCACTGTAAAAAGAAAACTAGAGGATTTTTGGAATAAATAATCTATTTTAGAGTTTATTT
GCTGATTTGCTTTTTACACACTTTCATGTGAAAGAGTGATAGGGAGAGGGAGCGAGGCTGGTGCCGCTTATTTTGAAGCTGGTGCCCTCC
CTCGCCGTGGCCACATGCTGGAAGCCTGAGGCCTCCCTGGACTGAGCCTGTGGCACTGCGTGCGGGACAGTTATGTTTCCTTGCCCCGTC
GCATTAATGAGGCCCTTCCACATCATTTTTAAACTAATGTTTTTCTATATTAACATTATTATGGATATTTGGCTTTCATAGGCCACACAC
AGGTGTGCTGCGCGGGAAGCCCCATGCTCCAATCAAAGGGATTTTTAGTAGTGCCTCTAAGCAAGCACCGATGAGTCAGTCCCACGTATT
TTCTTTTTTGTCAGTATTGTTTGGGAAGGAGACATGCCGGGATGTGTCATCGTGCCAAATACCACATTTCCTGTTGGCACAGTTTCACAG
AAGTAAACATAAGCATGTTTTAACAGGTTTTTCTTTTCTTTTTTCTTTTTTAAAATGTTTTATTTATTTAACCCGCCATTGTGTGTTTTT
AAGTATTTTCTTTTTTTAAGGAAAGGAAAAGCTTGTCACAATCTAACTGGCTATGTTATTATTATTAAATTTATGTTTTGCAACTTAGAA

>86969_86969_10_ST5-DENND5A_ST5_chr11_8772168_ENST00000534127_DENND5A_chr11_9163655_ENST00000328194_length(amino acids)=93AA_BP=
MRGKPHAPIKGIFSSASKQAPMSQSHVFSFLSVLFGKETCRDVSSCQIPHFLLAQFHRSKHKHVLTGFSFLFSFLKCFIYLTRHCVFLSI

--------------------------------------------------------------
>86969_86969_11_ST5-DENND5A_ST5_chr11_8772168_ENST00000534127_DENND5A_chr11_9163655_ENST00000527700_length(transcript)=986nt_BP=466nt
GGGGGTCGGGGGTCGGGGGCTGGGGGCTGAGGACTGAGTCGAGCCAGCAGCCCAGGGCATCTGTCCACGCTGTCAGAGGAGCCTCTGGGC
GTGGGGCTGGCCCTTAGAGGGCTACTGCGCTGCTTAACTTGCCTTTCACAGAAAACCACTGGAGGAGATACTCACAAAAATGAAGGGGAA
GAACAGGAAACAGGAAGACATGAGATGAAGGAAACAGGAGATTCAACATGGATTTCACACCCTTTGGAGAGTTTCTTTCTTGGATAATTC
AGGAAGATGAGAGACTGCTTAGGCGCCACCACTAGTACCATGAGTCCCTGCACTGGTTAAAGCCATCGCCACAACCTGGACAGGCAGCAA
GGGCTCTGGGTTTGCAGAGAGCCGAAATGACCATGACTGCCAACAAGAATTCCAGCATCACCCACGGAGCTGGTGGCACTAAAGCCCCTC
GGGGGACTCTGAGCAGAAAAAGCACAAACCTATTATGAGACATTAGAGAAGAATGAAGTAGTCCCTGAGGAAAACTGGCATACAAGAGCC
CGGAACTTCTGCCGATTTGTCACTGCAATCAACAATACTCCCCGGAACATCGGCAAGGATGGCAAGTTTCAGATGCTGGTGTGCTTGGGA
GCCAGAGATCACCTCCTACACCACTGGATTGCCCTGCTGGCTGACTGCCCCATCACTGCACACATGTATGAGGATGTGGCACTGATCAAA
GACCATACACTTGTCAATTCCTTGATTCGTGTGCTGCAGACATTGCAGGAGTTCAACATCACGCTGGAGACGTCCCTTGTCAAGGGCATC
GACATCTGACCTCCCAGCACCAGCCAGCAGCAGGACTGAGAAAGACTCACCCTGCAGCTCTGACCTTTTTTCCCAAAGGGACTTAAGCGA

>86969_86969_11_ST5-DENND5A_ST5_chr11_8772168_ENST00000534127_DENND5A_chr11_9163655_ENST00000527700_length(amino acids)=91AA_BP=
MSPTPAQSLKSLWEKRSELQGESFSVLLLAGAGRSDVDALDKGRLQRDVELLQCLQHTNQGIDKCMVFDQCHILIHVCSDGAVSQQGNPV

--------------------------------------------------------------
>86969_86969_12_ST5-DENND5A_ST5_chr11_8772168_ENST00000534127_DENND5A_chr11_9163655_ENST00000530044_length(transcript)=997nt_BP=466nt
GGGGGTCGGGGGTCGGGGGCTGGGGGCTGAGGACTGAGTCGAGCCAGCAGCCCAGGGCATCTGTCCACGCTGTCAGAGGAGCCTCTGGGC
GTGGGGCTGGCCCTTAGAGGGCTACTGCGCTGCTTAACTTGCCTTTCACAGAAAACCACTGGAGGAGATACTCACAAAAATGAAGGGGAA
GAACAGGAAACAGGAAGACATGAGATGAAGGAAACAGGAGATTCAACATGGATTTCACACCCTTTGGAGAGTTTCTTTCTTGGATAATTC
AGGAAGATGAGAGACTGCTTAGGCGCCACCACTAGTACCATGAGTCCCTGCACTGGTTAAAGCCATCGCCACAACCTGGACAGGCAGCAA
GGGCTCTGGGTTTGCAGAGAGCCGAAATGACCATGACTGCCAACAAGAATTCCAGCATCACCCACGGAGCTGGTGGCACTAAAGCCCCTC
GGGGGACTCTGAGCAGAAAAAGCACAAACCTATTATGAGACATTAGAGAAGAATGAAGTAGTCCCTGAGGAAAACTGGCATACAAGAGCC
CGGAACTTCTGCCGATTTGTCACTGCAATCAACAATACTCCCCGGAACATCGGCAAGGATGAGATCACCTCCTACACCACTGGATTGCCC
TGCTGGCTGACTGCCCCATCACTGCACACATGTATGAGGATGTGGCACTGATCAAAGACCATACACTTGTCAATTCCTTGATTCGTGTGC
TGCAGACATTGCAGGAGTTCAACATCACGCTGGAGACGTCCCTTGTCAAGGGCATCGACATCTGACCTCCCAGCACCAGCCAGCAGCAGG
ACTGAGAAAGACTCACCCTGCAGCTCTGACCTTTTTTCCCAAAGGGACTTAAGCGATTGTGCAGGAGTAGGAGACAAAATGTACACTCAC
TGTAAAAAGAAAACTAGAGGATTTTTGGAATAAATAATCTATTTTAGAGTTTATTTGCTGATTTGCTTTTTACACACTTTCATGTGAAAG

>86969_86969_12_ST5-DENND5A_ST5_chr11_8772168_ENST00000534127_DENND5A_chr11_9163655_ENST00000530044_length(amino acids)=91AA_BP=
MSPTPAQSLKSLWEKRSELQGESFSVLLLAGAGRSDVDALDKGRLQRDVELLQCLQHTNQGIDKCMVFDQCHILIHVCSDGAVSQQGNPV

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ST5-DENND5A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneST5chr11:8772168chr11:9163655ENST00000313726-220401_44726.6666666666666681138.0ABL1
HgeneST5chr11:8772168chr11:9163655ENST00000357665-321401_44726.6666666666666681138.0ABL1
HgeneST5chr11:8772168chr11:9163655ENST00000526757-219401_44726.666666666666668718.0ABL1
HgeneST5chr11:8772168chr11:9163655ENST00000530438-219401_44726.666666666666668718.0ABL1
HgeneST5chr11:8772168chr11:9163655ENST00000530991-117401_4470610.0ABL1
HgeneST5chr11:8772168chr11:9163655ENST00000534127-523401_44726.6666666666666681138.0ABL1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ST5-DENND5A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ST5-DENND5A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource