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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ST6GAL1-KNG1 (FusionGDB2 ID:86978)

Fusion Gene Summary for ST6GAL1-KNG1

check button Fusion gene summary
Fusion gene informationFusion gene name: ST6GAL1-KNG1
Fusion gene ID: 86978
HgeneTgene
Gene symbol

ST6GAL1

KNG1

Gene ID

6480

3827

Gene nameST6 beta-galactoside alpha-2,6-sialyltransferase 1kininogen 1
SynonymsSIAT1|ST6GalI|ST6NBDK|BK|HMWK|KNG
Cytomap

3q27.3

3q27.3

Type of geneprotein-codingprotein-coding
Descriptionbeta-galactoside alpha-2,6-sialyltransferase 1B-cell antigen CD75CMP-N-acetylneuraminate beta-galactosamide alpha-2,6-sialyltransferaseCMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1ST6 N-acetylgalactosaminide alpha-2,6-sialylkininogen-1alpha-2-thiol proteinase inhibitorbradykininfitzgerald factorhigh molecular weight kininogenwilliams-Fitzgerald-Flaujeac factor
Modification date2020032920200315
UniProtAcc.

P01042

Ensembl transtripts involved in fusion geneENST00000169298, ENST00000448044, 
ENST00000457772, ENST00000487031, 
ENST00000265023, ENST00000447445, 
ENST00000287611, 
Fusion gene scores* DoF score10 X 7 X 8=5607 X 7 X 4=196
# samples 139
** MAII scorelog2(13/560*10)=-2.10691520391651
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/196*10)=-1.12285674778553
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ST6GAL1 [Title/Abstract] AND KNG1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointST6GAL1(186761098)-KNG1(186461494), # samples:2
Anticipated loss of major functional domain due to fusion event.ST6GAL1-KNG1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneST6GAL1

GO:0006054

N-acetylneuraminate metabolic process

23999306

HgeneST6GAL1

GO:0018279

protein N-linked glycosylation via asparagine

23999306

HgeneST6GAL1

GO:0097503

sialylation

23999306

TgeneKNG1

GO:0007162

negative regulation of cell adhesion

11970955

TgeneKNG1

GO:0007204

positive regulation of cytosolic calcium ion concentration

16014619

TgeneKNG1

GO:0030195

negative regulation of blood coagulation

11970955

TgeneKNG1

GO:0045861

negative regulation of proteolysis

3488317


check buttonFusion gene breakpoints across ST6GAL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across KNG1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-55-6972-01AST6GAL1chr3

186761098

-KNG1chr3

186461494

+
ChimerDB4LUADTCGA-55-6972-01AST6GAL1chr3

186761098

+KNG1chr3

186461494

+
ChimerDB4STADTCGA-VQ-A92D-01AST6GAL1chr3

186681714

+KNG1chr3

186456888

+
ChimerDB4STADTCGA-VQ-A92DST6GAL1chr3

186681714

+KNG1chr3

186456887

+


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Fusion Gene ORF analysis for ST6GAL1-KNG1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000169298ENST00000265023ST6GAL1chr3

186761098

+KNG1chr3

186461494

+
5CDS-intronENST00000169298ENST00000447445ST6GAL1chr3

186761098

+KNG1chr3

186461494

+
5CDS-intronENST00000448044ENST00000265023ST6GAL1chr3

186761098

+KNG1chr3

186461494

+
5CDS-intronENST00000448044ENST00000447445ST6GAL1chr3

186761098

+KNG1chr3

186461494

+
5UTR-3CDSENST00000169298ENST00000265023ST6GAL1chr3

186681714

+KNG1chr3

186456888

+
5UTR-3CDSENST00000169298ENST00000265023ST6GAL1chr3

186681714

+KNG1chr3

186456887

+
5UTR-3CDSENST00000169298ENST00000287611ST6GAL1chr3

186681714

+KNG1chr3

186456888

+
5UTR-3CDSENST00000169298ENST00000287611ST6GAL1chr3

186681714

+KNG1chr3

186456887

+
5UTR-3CDSENST00000169298ENST00000447445ST6GAL1chr3

186681714

+KNG1chr3

186456888

+
5UTR-3CDSENST00000169298ENST00000447445ST6GAL1chr3

186681714

+KNG1chr3

186456887

+
5UTR-3CDSENST00000457772ENST00000265023ST6GAL1chr3

186681714

+KNG1chr3

186456888

+
5UTR-3CDSENST00000457772ENST00000265023ST6GAL1chr3

186681714

+KNG1chr3

186456887

+
5UTR-3CDSENST00000457772ENST00000287611ST6GAL1chr3

186681714

+KNG1chr3

186456888

+
5UTR-3CDSENST00000457772ENST00000287611ST6GAL1chr3

186681714

+KNG1chr3

186456887

+
5UTR-3CDSENST00000457772ENST00000447445ST6GAL1chr3

186681714

+KNG1chr3

186456888

+
5UTR-3CDSENST00000457772ENST00000447445ST6GAL1chr3

186681714

+KNG1chr3

186456887

+
Frame-shiftENST00000169298ENST00000287611ST6GAL1chr3

186761098

+KNG1chr3

186461494

+
Frame-shiftENST00000448044ENST00000287611ST6GAL1chr3

186761098

+KNG1chr3

186461494

+
intron-3CDSENST00000448044ENST00000265023ST6GAL1chr3

186681714

+KNG1chr3

186456888

+
intron-3CDSENST00000448044ENST00000265023ST6GAL1chr3

186681714

+KNG1chr3

186456887

+
intron-3CDSENST00000448044ENST00000287611ST6GAL1chr3

186681714

+KNG1chr3

186456888

+
intron-3CDSENST00000448044ENST00000287611ST6GAL1chr3

186681714

+KNG1chr3

186456887

+
intron-3CDSENST00000448044ENST00000447445ST6GAL1chr3

186681714

+KNG1chr3

186456888

+
intron-3CDSENST00000448044ENST00000447445ST6GAL1chr3

186681714

+KNG1chr3

186456887

+
intron-3CDSENST00000457772ENST00000287611ST6GAL1chr3

186761098

+KNG1chr3

186461494

+
intron-3CDSENST00000487031ENST00000265023ST6GAL1chr3

186681714

+KNG1chr3

186456888

+
intron-3CDSENST00000487031ENST00000265023ST6GAL1chr3

186681714

+KNG1chr3

186456887

+
intron-3CDSENST00000487031ENST00000287611ST6GAL1chr3

186761098

+KNG1chr3

186461494

+
intron-3CDSENST00000487031ENST00000287611ST6GAL1chr3

186681714

+KNG1chr3

186456888

+
intron-3CDSENST00000487031ENST00000287611ST6GAL1chr3

186681714

+KNG1chr3

186456887

+
intron-3CDSENST00000487031ENST00000447445ST6GAL1chr3

186681714

+KNG1chr3

186456888

+
intron-3CDSENST00000487031ENST00000447445ST6GAL1chr3

186681714

+KNG1chr3

186456887

+
intron-intronENST00000457772ENST00000265023ST6GAL1chr3

186761098

+KNG1chr3

186461494

+
intron-intronENST00000457772ENST00000447445ST6GAL1chr3

186761098

+KNG1chr3

186461494

+
intron-intronENST00000487031ENST00000265023ST6GAL1chr3

186761098

+KNG1chr3

186461494

+
intron-intronENST00000487031ENST00000447445ST6GAL1chr3

186761098

+KNG1chr3

186461494

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ST6GAL1-KNG1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ST6GAL1chr3186761098+KNG1chr3186461493+0.0053201930.99467975
ST6GAL1chr3186681714+KNG1chr3186456887+1.90E-060.9999981
ST6GAL1chr3186681714+KNG1chr3186456887+1.90E-060.9999981
ST6GAL1chr3186761098+KNG1chr3186461493+0.0053201930.99467975
ST6GAL1chr3186681714+KNG1chr3186456887+1.90E-060.9999981
ST6GAL1chr3186681714+KNG1chr3186456887+1.90E-060.9999981

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ST6GAL1-KNG1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:186761098/:186461494)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.KNG1

P01042

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ST6GAL1-KNG1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ST6GAL1-KNG1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ST6GAL1-KNG1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ST6GAL1-KNG1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource