FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:ST6GALNAC3-TRIT1 (FusionGDB2 ID:87006)

Fusion Gene Summary for ST6GALNAC3-TRIT1

check button Fusion gene summary
Fusion gene informationFusion gene name: ST6GALNAC3-TRIT1
Fusion gene ID: 87006
HgeneTgene
Gene symbol

ST6GALNAC3

TRIT1

Gene ID

256435

54802

Gene nameST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3tRNA isopentenyltransferase 1
SynonymsPRO7177|SIAT7C|ST6GALNACIII|STYCOXPD35|GRO1|IPPT|IPT|IPTase|MOD5|hGRO1
Cytomap

1p31.1

1p34.2

Type of geneprotein-codingprotein-coding
Descriptionalpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3GalNAc alpha-2,6-sialyltransferase IIIST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltranST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)tRNA dimethylallyltransferaseIPP transferaseisopentenyl-diphosphate:tRNA isopentenyltransferasetRNA dimethylallyltransferase, mitochondrialtRNA isopentenylpyrophosphate transferase
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000464140, ENST00000328299, 
ENST00000316891, ENST00000372818, 
ENST00000441669, ENST00000537440, 
ENST00000545233, ENST00000491865, 
ENST00000537223, ENST00000541099, 
ENST00000544981, 
Fusion gene scores* DoF score11 X 10 X 4=4405 X 5 X 3=75
# samples 116
** MAII scorelog2(11/440*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ST6GALNAC3 [Title/Abstract] AND TRIT1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointST6GALNAC3(76878102)-TRIT1(40315933), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneST6GALNAC3

GO:0006677

glycosylceramide metabolic process

17123352

HgeneST6GALNAC3

GO:0006687

glycosphingolipid metabolic process

17123352

HgeneST6GALNAC3

GO:0009100

glycoprotein metabolic process

17123352


check buttonFusion gene breakpoints across ST6GALNAC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TRIT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A91SST6GALNAC3chr1

76878102

+TRIT1chr1

40315933

-


Top

Fusion Gene ORF analysis for ST6GALNAC3-TRIT1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000464140ENST00000316891ST6GALNAC3chr1

76878102

+TRIT1chr1

40315933

-
3UTR-3CDSENST00000464140ENST00000372818ST6GALNAC3chr1

76878102

+TRIT1chr1

40315933

-
3UTR-3CDSENST00000464140ENST00000441669ST6GALNAC3chr1

76878102

+TRIT1chr1

40315933

-
3UTR-5UTRENST00000464140ENST00000537440ST6GALNAC3chr1

76878102

+TRIT1chr1

40315933

-
3UTR-5UTRENST00000464140ENST00000545233ST6GALNAC3chr1

76878102

+TRIT1chr1

40315933

-
3UTR-intronENST00000464140ENST00000491865ST6GALNAC3chr1

76878102

+TRIT1chr1

40315933

-
3UTR-intronENST00000464140ENST00000537223ST6GALNAC3chr1

76878102

+TRIT1chr1

40315933

-
3UTR-intronENST00000464140ENST00000541099ST6GALNAC3chr1

76878102

+TRIT1chr1

40315933

-
3UTR-intronENST00000464140ENST00000544981ST6GALNAC3chr1

76878102

+TRIT1chr1

40315933

-
5CDS-5UTRENST00000328299ENST00000537440ST6GALNAC3chr1

76878102

+TRIT1chr1

40315933

-
5CDS-5UTRENST00000328299ENST00000545233ST6GALNAC3chr1

76878102

+TRIT1chr1

40315933

-
5CDS-intronENST00000328299ENST00000491865ST6GALNAC3chr1

76878102

+TRIT1chr1

40315933

-
5CDS-intronENST00000328299ENST00000537223ST6GALNAC3chr1

76878102

+TRIT1chr1

40315933

-
5CDS-intronENST00000328299ENST00000541099ST6GALNAC3chr1

76878102

+TRIT1chr1

40315933

-
5CDS-intronENST00000328299ENST00000544981ST6GALNAC3chr1

76878102

+TRIT1chr1

40315933

-
In-frameENST00000328299ENST00000316891ST6GALNAC3chr1

76878102

+TRIT1chr1

40315933

-
In-frameENST00000328299ENST00000372818ST6GALNAC3chr1

76878102

+TRIT1chr1

40315933

-
In-frameENST00000328299ENST00000441669ST6GALNAC3chr1

76878102

+TRIT1chr1

40315933

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000328299ST6GALNAC3chr176878102+ENST00000441669TRIT1chr140315933-2302771251608527
ENST00000328299ST6GALNAC3chr176878102+ENST00000316891TRIT1chr140315933-2308771251614529
ENST00000328299ST6GALNAC3chr176878102+ENST00000372818TRIT1chr140315933-2230771251536503

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000328299ENST00000441669ST6GALNAC3chr176878102+TRIT1chr140315933-0.0005870670.9994129
ENST00000328299ENST00000316891ST6GALNAC3chr176878102+TRIT1chr140315933-0.0005956280.99940443
ENST00000328299ENST00000372818ST6GALNAC3chr176878102+TRIT1chr140315933-0.0007228910.9992772

Top

Fusion Genomic Features for ST6GALNAC3-TRIT1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for ST6GALNAC3-TRIT1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:76878102/chr1:40315933)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneST6GALNAC3chr1:76878102chr1:40315933ENST00000328299+351_8207306.0Topological domainCytoplasmic
HgeneST6GALNAC3chr1:76878102chr1:40315933ENST00000328299+359_28207306.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneTRIT1chr1:76878102chr1:40315933ENST00000316891311395_425186468.0Zinc fingerNote=Matrin-type
TgeneTRIT1chr1:76878102chr1:40315933ENST00000372818310395_425186442.0Zinc fingerNote=Matrin-type
TgeneTRIT1chr1:76878102chr1:40315933ENST0000044166919395_425106386.0Zinc fingerNote=Matrin-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneST6GALNAC3chr1:76878102chr1:40315933ENST00000328299+3529_305207306.0Topological domainLumenal
TgeneTRIT1chr1:76878102chr1:40315933ENST0000031689131132_37186468.0RegionSubstrate binding
TgeneTRIT1chr1:76878102chr1:40315933ENST0000037281831032_37186442.0RegionSubstrate binding
TgeneTRIT1chr1:76878102chr1:40315933ENST000004416691932_37106386.0RegionSubstrate binding


Top

Fusion Gene Sequence for ST6GALNAC3-TRIT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>87006_87006_1_ST6GALNAC3-TRIT1_ST6GALNAC3_chr1_76878102_ENST00000328299_TRIT1_chr1_40315933_ENST00000316891_length(transcript)=2308nt_BP=771nt
GCAGCTTACACCGCGGTCCCCTTATTTGGATCTGCGGGAATGTGGGCTGGAGAGGTCCTGCCGTGGTACCAGCCTCCAGCCTGCCCCCAG
GACTGCCCCTGACCCAGGCGCGCCCGCTGCTCGGTGGCAGGAGGGCCGGCGGAGCGCCATGGCCTGCATCCTGAAGAGAAAGTCTGTGAT
TGCTGTGAGCTTCATAGCAGCGTTCCTTTTCCTGCTGGTTGTGCGTCTTGTAAATGAAGTGAATTTCCCATTGCTACTAAACTGCTTTGG
ACAACCTGGTACAAAGTGGATACCATTCTCCTACACATACAGGCGGCCCCTTCGAACTCACTATGGATACATAAATGTGAAGACACAAGA
GCCTTTGCAACTGGACTGTGACCTTTGTGCCATAGTGTCAAACTCAGGTCAGATGGTTGGCCAGAAGGTGGGAAATGAGATAGATCGATC
CTCCTGCATTTGGAGAATGAACAATGCCCCCACCAAAGGTTATGAAGAAGATGTCGGCCGCATGACCATGATTCGAGTTGTGTCCCATAC
CAGCGTTCCTCTTTTGCTAAAAAACCCTGATTATTTTTTCAAGGAAGCGAATACTACTATTTATGTTATTTGGGGACCTTTCCGCAATAT
GAGGAAAGATGGCAATGGCATCGTTTACAACATGTTGAAAAAGACAGTTGGTATCTATCCGAATGCCCAAATATACGTGACCACAGAGAA
GCGCATGAGTTACTGTGATGGAGTTTTTAAGAAGGAAACTGGGAAGGACAGGAGCTTGCAAGTTTTTGAAGAAACAGGAATCTCTCATAG
TGAATTTCTCCATCGTCAACATACGGAAGAAGGTGGTGGTCCCCTTGGAGGTCCTCTGAAGTTCTCTAACCCTTGCATCCTTTGGCTTCA
TGCTGACCAGGCAGTTCTAGATGAGCGCTTGGATAAGAGGGTGGATGACATGCTTGCTGCTGGGCTCTTGGAGGAACTAAGAGATTTTCA
CAGACGCTATAATCAGAAGAATGTTTCGGAAAATAGCCAGGACTATCAACATGGTATCTTCCAATCAATTGGCTTCAAGGAATTTCACGA
GTACCTGATCACTGAGGGAAAATGCACACTGGAGACTAGTAACCAGCTTCTAAAGAAAGGTATTGAGGCTCTGAAACAAGTAACTAAGAG
ATATGCCCGGAAACAAAACCGATGGGTTAAAAACCGTTTTTTGAGCAGACCTGGTCCCATTGTCCCCCCTGTCTATGGCTTAGAGGTATC
TGATGTCTCGAAGTGGGAAGAGTCTGTTCTTGAACCTGCTCTTGAAATCGTGCAAAGTTTCATCCAGGGCCACAAGCCTACAGCCACTCC
AATAAAGATGCCATACAATGAAGCTGAGAACAAGAGAAGTTATCACCTGTGTGACCTCTGTGATCGAATCATCATTGGGGATCGCGAATG
GGCAGCGCACATAAAATCCAAATCCCACTTGAACCAACTGAAGAAAAGAAGAAGATTGGACTCAGATGCTGTCAACACCATAGAAAGTCA
GAGTGTTTCCCCAGACCATAACAAAGAACCTAAAGAGAAGGGATCCCCAGGGCAGAATGATCAAGAGCTGAAATGCAGCGTTTAAGAGAC
ATGTCCAGTGGCCTTTGGAAAGGTGGTGGGGATCCAGTTCAGGAGGGAGGGGTATGTTTGTCTCCCAGTCTGGGCAAAGGAGTGCTATGC
GGAATTCTCTGCATAGCAGAAAAGCTCCCACCATTTTCTTTTGATGTGGTTTTAAAGTCTCACGTTCTCTATAATAGAAACAGCAGGTCT
TGTCAGCTCCTTGTGTGGCTGATGTGTCTGGAAATGATGTAGTTCAGGAAAGCATTTTTTTTTTCTTTGAACCTTAAAGGTTCTATTATT
AAAAGCAGCACAGATTCCACATTTTTATACATGAGGATCTTCTTTGTGGTGAATACCAGGATTGACTGCATCCCTTTAAAGAAGTTTTAT
GTCCCTGACTCTGGCTAAAATTATCTAATTTCCAGATGCTTTTGTAGATGACTGAAGTATTTGTGAGCCACATATTGGGAGTTCTAGATT
TGAGTGAATGGCAGGAAAGGGCCATCTCCATTGAGATGATTAAGTGAACCAAACTAGTTCTCAGAATTCTACAGAGAAGGAGGGAATCAG
ACTGAGGAAGCTGTGACATAGGACTTGAAGACCAAAGACTTTGAAATTTGCGAGCTGCTCATGTGTGAGTTATTATCACTGCTGTCTTTC

>87006_87006_1_ST6GALNAC3-TRIT1_ST6GALNAC3_chr1_76878102_ENST00000328299_TRIT1_chr1_40315933_ENST00000316891_length(amino acids)=529AA_BP=248
MDLRECGLERSCRGTSLQPAPRTAPDPGAPAARWQEGRRSAMACILKRKSVIAVSFIAAFLFLLVVRLVNEVNFPLLLNCFGQPGTKWIP
FSYTYRRPLRTHYGYINVKTQEPLQLDCDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSVPLLLKN
PDYFFKEANTTIYVIWGPFRNMRKDGNGIVYNMLKKTVGIYPNAQIYVTTEKRMSYCDGVFKKETGKDRSLQVFEETGISHSEFLHRQHT
EEGGGPLGGPLKFSNPCILWLHADQAVLDERLDKRVDDMLAAGLLEELRDFHRRYNQKNVSENSQDYQHGIFQSIGFKEFHEYLITEGKC
TLETSNQLLKKGIEALKQVTKRYARKQNRWVKNRFLSRPGPIVPPVYGLEVSDVSKWEESVLEPALEIVQSFIQGHKPTATPIKMPYNEA

--------------------------------------------------------------
>87006_87006_2_ST6GALNAC3-TRIT1_ST6GALNAC3_chr1_76878102_ENST00000328299_TRIT1_chr1_40315933_ENST00000372818_length(transcript)=2230nt_BP=771nt
GCAGCTTACACCGCGGTCCCCTTATTTGGATCTGCGGGAATGTGGGCTGGAGAGGTCCTGCCGTGGTACCAGCCTCCAGCCTGCCCCCAG
GACTGCCCCTGACCCAGGCGCGCCCGCTGCTCGGTGGCAGGAGGGCCGGCGGAGCGCCATGGCCTGCATCCTGAAGAGAAAGTCTGTGAT
TGCTGTGAGCTTCATAGCAGCGTTCCTTTTCCTGCTGGTTGTGCGTCTTGTAAATGAAGTGAATTTCCCATTGCTACTAAACTGCTTTGG
ACAACCTGGTACAAAGTGGATACCATTCTCCTACACATACAGGCGGCCCCTTCGAACTCACTATGGATACATAAATGTGAAGACACAAGA
GCCTTTGCAACTGGACTGTGACCTTTGTGCCATAGTGTCAAACTCAGGTCAGATGGTTGGCCAGAAGGTGGGAAATGAGATAGATCGATC
CTCCTGCATTTGGAGAATGAACAATGCCCCCACCAAAGGTTATGAAGAAGATGTCGGCCGCATGACCATGATTCGAGTTGTGTCCCATAC
CAGCGTTCCTCTTTTGCTAAAAAACCCTGATTATTTTTTCAAGGAAGCGAATACTACTATTTATGTTATTTGGGGACCTTTCCGCAATAT
GAGGAAAGATGGCAATGGCATCGTTTACAACATGTTGAAAAAGACAGTTGGTATCTATCCGAATGCCCAAATATACGTGACCACAGAGAA
GCGCATGAGTTACTGTGATGGAGTTTTTAAGAAGGAAACTGGGAAGGACAGGAGCTTGCAAGTTTTTGAAGAAACAGGAATCTCTCATAG
TGAATTTCTCCATCGTCAACATACGGAAGAAGGTGGTGGTCCCCTTGGAGGTCCTCTGAAGTTCTCTAACCCTTGCATCCTTTGGCTTCA
TGCTGACCAGGCAGTTCTAGATGAGCGCTTGGATAAGAGGGTGGATGACATGCTTGCTGCTGGGCTCTTGGAGGAACTAAGAGATTTTCA
CAGACGCTATAATCAGAAGAATGTTTCGGAAAATAGCCAGGACTATCAACATGGTATCTTCCAATCAATTGGCTTCAAGGAATTTCACGA
GTACCTGATCACTGAGGGAAAATGCACACTGGAGACTAGTAACCAGCTTCTAAAGAAAGGACCTGGTCCCATTGTCCCCCCTGTCTATGG
CTTAGAGGTATCTGATGTCTCGAAGTGGGAAGAGTCTGTTCTTGAACCTGCTCTTGAAATCGTGCAAAGTTTCATCCAGGGCCACAAGCC
TACAGCCACTCCAATAAAGATGCCATACAATGAAGCTGAGAACAAGAGAAGTTATCACCTGTGTGACCTCTGTGATCGAATCATCATTGG
GGATCGCGAATGGGCAGCGCACATAAAATCCAAATCCCACTTGAACCAACTGAAGAAAAGAAGAAGATTGGACTCAGATGCTGTCAACAC
CATAGAAAGTCAGAGTGTTTCCCCAGACCATAACAAAGAACCTAAAGAGAAGGGATCCCCAGGGCAGAATGATCAAGAGCTGAAATGCAG
CGTTTAAGAGACATGTCCAGTGGCCTTTGGAAAGGTGGTGGGGATCCAGTTCAGGAGGGAGGGGTATGTTTGTCTCCCAGTCTGGGCAAA
GGAGTGCTATGCGGAATTCTCTGCATAGCAGAAAAGCTCCCACCATTTTCTTTTGATGTGGTTTTAAAGTCTCACGTTCTCTATAATAGA
AACAGCAGGTCTTGTCAGCTCCTTGTGTGGCTGATGTGTCTGGAAATGATGTAGTTCAGGAAAGCATTTTTTTTTTCTTTGAACCTTAAA
GGTTCTATTATTAAAAGCAGCACAGATTCCACATTTTTATACATGAGGATCTTCTTTGTGGTGAATACCAGGATTGACTGCATCCCTTTA
AAGAAGTTTTATGTCCCTGACTCTGGCTAAAATTATCTAATTTCCAGATGCTTTTGTAGATGACTGAAGTATTTGTGAGCCACATATTGG
GAGTTCTAGATTTGAGTGAATGGCAGGAAAGGGCCATCTCCATTGAGATGATTAAGTGAACCAAACTAGTTCTCAGAATTCTACAGAGAA
GGAGGGAATCAGACTGAGGAAGCTGTGACATAGGACTTGAAGACCAAAGACTTTGAAATTTGCGAGCTGCTCATGTGTGAGTTATTATCA

>87006_87006_2_ST6GALNAC3-TRIT1_ST6GALNAC3_chr1_76878102_ENST00000328299_TRIT1_chr1_40315933_ENST00000372818_length(amino acids)=503AA_BP=248
MDLRECGLERSCRGTSLQPAPRTAPDPGAPAARWQEGRRSAMACILKRKSVIAVSFIAAFLFLLVVRLVNEVNFPLLLNCFGQPGTKWIP
FSYTYRRPLRTHYGYINVKTQEPLQLDCDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSVPLLLKN
PDYFFKEANTTIYVIWGPFRNMRKDGNGIVYNMLKKTVGIYPNAQIYVTTEKRMSYCDGVFKKETGKDRSLQVFEETGISHSEFLHRQHT
EEGGGPLGGPLKFSNPCILWLHADQAVLDERLDKRVDDMLAAGLLEELRDFHRRYNQKNVSENSQDYQHGIFQSIGFKEFHEYLITEGKC
TLETSNQLLKKGPGPIVPPVYGLEVSDVSKWEESVLEPALEIVQSFIQGHKPTATPIKMPYNEAENKRSYHLCDLCDRIIIGDREWAAHI

--------------------------------------------------------------
>87006_87006_3_ST6GALNAC3-TRIT1_ST6GALNAC3_chr1_76878102_ENST00000328299_TRIT1_chr1_40315933_ENST00000441669_length(transcript)=2302nt_BP=771nt
GCAGCTTACACCGCGGTCCCCTTATTTGGATCTGCGGGAATGTGGGCTGGAGAGGTCCTGCCGTGGTACCAGCCTCCAGCCTGCCCCCAG
GACTGCCCCTGACCCAGGCGCGCCCGCTGCTCGGTGGCAGGAGGGCCGGCGGAGCGCCATGGCCTGCATCCTGAAGAGAAAGTCTGTGAT
TGCTGTGAGCTTCATAGCAGCGTTCCTTTTCCTGCTGGTTGTGCGTCTTGTAAATGAAGTGAATTTCCCATTGCTACTAAACTGCTTTGG
ACAACCTGGTACAAAGTGGATACCATTCTCCTACACATACAGGCGGCCCCTTCGAACTCACTATGGATACATAAATGTGAAGACACAAGA
GCCTTTGCAACTGGACTGTGACCTTTGTGCCATAGTGTCAAACTCAGGTCAGATGGTTGGCCAGAAGGTGGGAAATGAGATAGATCGATC
CTCCTGCATTTGGAGAATGAACAATGCCCCCACCAAAGGTTATGAAGAAGATGTCGGCCGCATGACCATGATTCGAGTTGTGTCCCATAC
CAGCGTTCCTCTTTTGCTAAAAAACCCTGATTATTTTTTCAAGGAAGCGAATACTACTATTTATGTTATTTGGGGACCTTTCCGCAATAT
GAGGAAAGATGGCAATGGCATCGTTTACAACATGTTGAAAAAGACAGTTGGTATCTATCCGAATGCCCAAATATACGTGACCACAGAGAA
GCGCATGAGTTACTGTGATGGAGTTTTTAAGAAGGAAACTGGGAAGGACAGGAGCTTGCAAGTTTTTGAAGAAACAGGAATCTCTCATAG
TGAATTTCTCCATCGTCAACATACGGAAGAAGGTGGTGGTCCCCTTGGAGGTCCTCTGAAGTTCTCTAACCCTTGCATCCTTTGGCTTCA
TGCTGACCAGGCAGATGAGCGCTTGGATAAGAGGGTGGATGACATGCTTGCTGCTGGGCTCTTGGAGGAACTAAGAGATTTTCACAGACG
CTATAATCAGAAGAATGTTTCGGAAAATAGCCAGGACTATCAACATGGTATCTTCCAATCAATTGGCTTCAAGGAATTTCACGAGTACCT
GATCACTGAGGGAAAATGCACACTGGAGACTAGTAACCAGCTTCTAAAGAAAGGTATTGAGGCTCTGAAACAAGTAACTAAGAGATATGC
CCGGAAACAAAACCGATGGGTTAAAAACCGTTTTTTGAGCAGACCTGGTCCCATTGTCCCCCCTGTCTATGGCTTAGAGGTATCTGATGT
CTCGAAGTGGGAAGAGTCTGTTCTTGAACCTGCTCTTGAAATCGTGCAAAGTTTCATCCAGGGCCACAAGCCTACAGCCACTCCAATAAA
GATGCCATACAATGAAGCTGAGAACAAGAGAAGTTATCACCTGTGTGACCTCTGTGATCGAATCATCATTGGGGATCGCGAATGGGCAGC
GCACATAAAATCCAAATCCCACTTGAACCAACTGAAGAAAAGAAGAAGATTGGACTCAGATGCTGTCAACACCATAGAAAGTCAGAGTGT
TTCCCCAGACCATAACAAAGAACCTAAAGAGAAGGGATCCCCAGGGCAGAATGATCAAGAGCTGAAATGCAGCGTTTAAGAGACATGTCC
AGTGGCCTTTGGAAAGGTGGTGGGGATCCAGTTCAGGAGGGAGGGGTATGTTTGTCTCCCAGTCTGGGCAAAGGAGTGCTATGCGGAATT
CTCTGCATAGCAGAAAAGCTCCCACCATTTTCTTTTGATGTGGTTTTAAAGTCTCACGTTCTCTATAATAGAAACAGCAGGTCTTGTCAG
CTCCTTGTGTGGCTGATGTGTCTGGAAATGATGTAGTTCAGGAAAGCATTTTTTTTTTCTTTGAACCTTAAAGGTTCTATTATTAAAAGC
AGCACAGATTCCACATTTTTATACATGAGGATCTTCTTTGTGGTGAATACCAGGATTGACTGCATCCCTTTAAAGAAGTTTTATGTCCCT
GACTCTGGCTAAAATTATCTAATTTCCAGATGCTTTTGTAGATGACTGAAGTATTTGTGAGCCACATATTGGGAGTTCTAGATTTGAGTG
AATGGCAGGAAAGGGCCATCTCCATTGAGATGATTAAGTGAACCAAACTAGTTCTCAGAATTCTACAGAGAAGGAGGGAATCAGACTGAG
GAAGCTGTGACATAGGACTTGAAGACCAAAGACTTTGAAATTTGCGAGCTGCTCATGTGTGAGTTATTATCACTGCTGTCTTTCTATTGA

>87006_87006_3_ST6GALNAC3-TRIT1_ST6GALNAC3_chr1_76878102_ENST00000328299_TRIT1_chr1_40315933_ENST00000441669_length(amino acids)=527AA_BP=248
MDLRECGLERSCRGTSLQPAPRTAPDPGAPAARWQEGRRSAMACILKRKSVIAVSFIAAFLFLLVVRLVNEVNFPLLLNCFGQPGTKWIP
FSYTYRRPLRTHYGYINVKTQEPLQLDCDLCAIVSNSGQMVGQKVGNEIDRSSCIWRMNNAPTKGYEEDVGRMTMIRVVSHTSVPLLLKN
PDYFFKEANTTIYVIWGPFRNMRKDGNGIVYNMLKKTVGIYPNAQIYVTTEKRMSYCDGVFKKETGKDRSLQVFEETGISHSEFLHRQHT
EEGGGPLGGPLKFSNPCILWLHADQADERLDKRVDDMLAAGLLEELRDFHRRYNQKNVSENSQDYQHGIFQSIGFKEFHEYLITEGKCTL
ETSNQLLKKGIEALKQVTKRYARKQNRWVKNRFLSRPGPIVPPVYGLEVSDVSKWEESVLEPALEIVQSFIQGHKPTATPIKMPYNEAEN

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for ST6GALNAC3-TRIT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneTRIT1chr1:76878102chr1:40315933ENST00000316891311233_255186.66666666666666468.0isopentenylpyrophosphate transferase
TgeneTRIT1chr1:76878102chr1:40315933ENST00000372818310233_255186.66666666666666442.0isopentenylpyrophosphate transferase
TgeneTRIT1chr1:76878102chr1:40315933ENST0000044166919233_255106.66666666666667386.0isopentenylpyrophosphate transferase
TgeneTRIT1chr1:76878102chr1:40315933ENST00000316891311281_283186.66666666666666468.0substrate tRNA
TgeneTRIT1chr1:76878102chr1:40315933ENST00000316891311313_331186.66666666666666468.0substrate tRNA
TgeneTRIT1chr1:76878102chr1:40315933ENST00000316891311323_330186.66666666666666468.0substrate tRNA
TgeneTRIT1chr1:76878102chr1:40315933ENST00000372818310281_283186.66666666666666442.0substrate tRNA
TgeneTRIT1chr1:76878102chr1:40315933ENST00000372818310313_331186.66666666666666442.0substrate tRNA
TgeneTRIT1chr1:76878102chr1:40315933ENST00000372818310323_330186.66666666666666442.0substrate tRNA
TgeneTRIT1chr1:76878102chr1:40315933ENST0000044166919183_187106.66666666666667386.0substrate tRNA
TgeneTRIT1chr1:76878102chr1:40315933ENST0000044166919281_283106.66666666666667386.0substrate tRNA
TgeneTRIT1chr1:76878102chr1:40315933ENST0000044166919313_331106.66666666666667386.0substrate tRNA
TgeneTRIT1chr1:76878102chr1:40315933ENST0000044166919323_330106.66666666666667386.0substrate tRNA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneTRIT1chr1:76878102chr1:40315933ENST00000316891311183_187186.66666666666666468.0substrate tRNA
TgeneTRIT1chr1:76878102chr1:40315933ENST0000031689131155_58186.66666666666666468.0substrate tRNA
TgeneTRIT1chr1:76878102chr1:40315933ENST00000372818310183_187186.66666666666666442.0substrate tRNA
TgeneTRIT1chr1:76878102chr1:40315933ENST0000037281831055_58186.66666666666666442.0substrate tRNA
TgeneTRIT1chr1:76878102chr1:40315933ENST000004416691955_58106.66666666666667386.0substrate tRNA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for ST6GALNAC3-TRIT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for ST6GALNAC3-TRIT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource