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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ST7-ASZ1 (FusionGDB2 ID:87013)

Fusion Gene Summary for ST7-ASZ1

check button Fusion gene summary
Fusion gene informationFusion gene name: ST7-ASZ1
Fusion gene ID: 87013
HgeneTgene
Gene symbol

ST7

ASZ1

Gene ID

93655

136991

Gene nameST7 overlapping transcript 3ankyrin repeat, SAM and basic leucine zipper domain containing 1
SynonymsNCRNA00026|ST7|ST7OT3ALP1|ANKL1|C7orf7|CT1.19|GASZ|Orf3
Cytomap

7q31.2

7q31.2

Type of genencRNAprotein-coding
DescriptionST7 overlapping transcript 3 (non-coding RNA)ST7 overlapping transcript 3 (non-protein coding)suppression of tumorigenicity 7ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1ankyrin-like 1ankyrin-like protein 1germ cell-specific ankyrin, SAM and basic leucine zipper domain-containing protein
Modification date2020031320200313
UniProtAcc.

Q8WWH4

Ensembl transtripts involved in fusion geneENST00000265437, ENST00000323984, 
ENST00000393446, ENST00000393449, 
ENST00000393451, ENST00000393443, 
ENST00000393444, ENST00000393447, 
ENST00000422922, ENST00000432298, 
ENST00000465133, ENST00000487459, 
ENST00000284629, 
Fusion gene scores* DoF score17 X 11 X 9=16835 X 4 X 4=80
# samples 235
** MAII scorelog2(23/1683*10)=-2.87132941038557
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ST7 [Title/Abstract] AND ASZ1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointST7(116593745)-ASZ1(117024914), # samples:2
ST7(116595207)-ASZ1(117025863), # samples:2
ST7(116593745)-ASZ1(117025863), # samples:2
Anticipated loss of major functional domain due to fusion event.ST7-ASZ1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
ST7-ASZ1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ST7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ASZ1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-86-8672-01AST7chr7

116593745

+ASZ1chr7

117024914

-
ChimerDB4LUADTCGA-86-8672-01AST7chr7

116593745

-ASZ1chr7

117025863

-
ChimerDB4LUADTCGA-86-8672-01AST7chr7

116593745

+ASZ1chr7

117025863

-
ChimerDB4LUADTCGA-86-8672-01AST7chr7

116595207

+ASZ1chr7

117025863

-


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Fusion Gene ORF analysis for ST7-ASZ1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000265437ENST00000284629ST7chr7

116593745

+ASZ1chr7

117024914

-
Frame-shiftENST00000265437ENST00000284629ST7chr7

116593745

+ASZ1chr7

117025863

-
Frame-shiftENST00000323984ENST00000284629ST7chr7

116593745

+ASZ1chr7

117024914

-
Frame-shiftENST00000323984ENST00000284629ST7chr7

116593745

+ASZ1chr7

117025863

-
Frame-shiftENST00000393446ENST00000284629ST7chr7

116593745

+ASZ1chr7

117024914

-
Frame-shiftENST00000393446ENST00000284629ST7chr7

116593745

+ASZ1chr7

117025863

-
Frame-shiftENST00000393449ENST00000284629ST7chr7

116593745

+ASZ1chr7

117024914

-
Frame-shiftENST00000393449ENST00000284629ST7chr7

116593745

+ASZ1chr7

117025863

-
Frame-shiftENST00000393451ENST00000284629ST7chr7

116593745

+ASZ1chr7

117024914

-
Frame-shiftENST00000393451ENST00000284629ST7chr7

116593745

+ASZ1chr7

117025863

-
intron-3CDSENST00000265437ENST00000284629ST7chr7

116595207

+ASZ1chr7

117025863

-
intron-3CDSENST00000323984ENST00000284629ST7chr7

116595207

+ASZ1chr7

117025863

-
intron-3CDSENST00000393443ENST00000284629ST7chr7

116593745

+ASZ1chr7

117024914

-
intron-3CDSENST00000393443ENST00000284629ST7chr7

116593745

+ASZ1chr7

117025863

-
intron-3CDSENST00000393443ENST00000284629ST7chr7

116595207

+ASZ1chr7

117025863

-
intron-3CDSENST00000393444ENST00000284629ST7chr7

116593745

+ASZ1chr7

117024914

-
intron-3CDSENST00000393444ENST00000284629ST7chr7

116593745

+ASZ1chr7

117025863

-
intron-3CDSENST00000393444ENST00000284629ST7chr7

116595207

+ASZ1chr7

117025863

-
intron-3CDSENST00000393446ENST00000284629ST7chr7

116595207

+ASZ1chr7

117025863

-
intron-3CDSENST00000393447ENST00000284629ST7chr7

116593745

+ASZ1chr7

117024914

-
intron-3CDSENST00000393447ENST00000284629ST7chr7

116593745

+ASZ1chr7

117025863

-
intron-3CDSENST00000393447ENST00000284629ST7chr7

116595207

+ASZ1chr7

117025863

-
intron-3CDSENST00000393449ENST00000284629ST7chr7

116595207

+ASZ1chr7

117025863

-
intron-3CDSENST00000393451ENST00000284629ST7chr7

116595207

+ASZ1chr7

117025863

-
intron-3CDSENST00000422922ENST00000284629ST7chr7

116593745

+ASZ1chr7

117024914

-
intron-3CDSENST00000422922ENST00000284629ST7chr7

116593745

+ASZ1chr7

117025863

-
intron-3CDSENST00000422922ENST00000284629ST7chr7

116595207

+ASZ1chr7

117025863

-
intron-3CDSENST00000432298ENST00000284629ST7chr7

116593745

+ASZ1chr7

117024914

-
intron-3CDSENST00000432298ENST00000284629ST7chr7

116593745

+ASZ1chr7

117025863

-
intron-3CDSENST00000432298ENST00000284629ST7chr7

116595207

+ASZ1chr7

117025863

-
intron-3CDSENST00000465133ENST00000284629ST7chr7

116593745

+ASZ1chr7

117024914

-
intron-3CDSENST00000465133ENST00000284629ST7chr7

116593745

+ASZ1chr7

117025863

-
intron-3CDSENST00000465133ENST00000284629ST7chr7

116595207

+ASZ1chr7

117025863

-
intron-3CDSENST00000487459ENST00000284629ST7chr7

116593745

+ASZ1chr7

117024914

-
intron-3CDSENST00000487459ENST00000284629ST7chr7

116593745

+ASZ1chr7

117025863

-
intron-3CDSENST00000487459ENST00000284629ST7chr7

116595207

+ASZ1chr7

117025863

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for ST7-ASZ1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ST7-ASZ1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:116593745/:117024914)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ASZ1

Q8WWH4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with pi-bodies suggests a participation in the primary piRNAs metabolic process. Required prior to the pachytene stage to facilitate the production of multiple types of piRNAs, including those associated with repeats involved in the regulation of retrotransposons. May act by mediating protein-protein interactions during germ cell maturation (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ST7-ASZ1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ST7-ASZ1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ST7-ASZ1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ST7-ASZ1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource