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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ST8SIA1-AEBP2 (FusionGDB2 ID:87042)

Fusion Gene Summary for ST8SIA1-AEBP2

check button Fusion gene summary
Fusion gene informationFusion gene name: ST8SIA1-AEBP2
Fusion gene ID: 87042
HgeneTgene
Gene symbol

ST8SIA1

AEBP2

Gene ID

6489

121536

Gene nameST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1AE binding protein 2
SynonymsGD3S|SIAT8|SIAT8-A|SIAT8A|ST8SiaI-
Cytomap

12p12.1

12p12.3

Type of geneprotein-codingprotein-coding
Descriptionalpha-N-acetylneuraminide alpha-2,8-sialyltransferaseST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 1alpha-2,8-sialyltransferase 8Adisialoganglioside (GD3) synthaseganglioside GD3 synthaseganglioside GT3 synthaseganglioside-specific alphazinc finger protein AEBP2AE(adipocyte enhancer)-binding protein 2adipocyte enhancer-binding protein 2
Modification date2020031320200313
UniProtAcc.

Q6ZN18

Ensembl transtripts involved in fusion geneENST00000396037, ENST00000539510, 
ENST00000381424, ENST00000404299, 
ENST00000536558, 		ENST00000266508, 
ENST00000360995, ENST00000398864, 
ENST00000541908, 
Fusion gene scores* DoF score10 X 7 X 6=42011 X 13 X 6=858
# samples 1115
** MAII scorelog2(11/420*10)=-1.93288580414146
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/858*10)=-2.51601514700366
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ST8SIA1 [Title/Abstract] AND AEBP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointAEBP2(19653155)-ST8SIA1(22354972), # samples:2
ST8SIA1(22401940)-AEBP2(19665332), # samples:3
Anticipated loss of major functional domain due to fusion event.AEBP2-ST8SIA1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
AEBP2-ST8SIA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
AEBP2-ST8SIA1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
ST8SIA1-AEBP2 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ST8SIA1-AEBP2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
ST8SIA1-AEBP2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ST8SIA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AEBP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-ER-A193-06AST8SIA1chr12

22401940

-AEBP2chr12

19665332

+


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Fusion Gene ORF analysis for ST8SIA1-AEBP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000396037ENST00000266508ST8SIA1chr12

22401940

-AEBP2chr12

19665332

+
Frame-shiftENST00000396037ENST00000360995ST8SIA1chr12

22401940

-AEBP2chr12

19665332

+
Frame-shiftENST00000396037ENST00000398864ST8SIA1chr12

22401940

-AEBP2chr12

19665332

+
Frame-shiftENST00000396037ENST00000541908ST8SIA1chr12

22401940

-AEBP2chr12

19665332

+
In-frameENST00000539510ENST00000266508ST8SIA1chr12

22401940

-AEBP2chr12

19665332

+
In-frameENST00000539510ENST00000360995ST8SIA1chr12

22401940

-AEBP2chr12

19665332

+
In-frameENST00000539510ENST00000398864ST8SIA1chr12

22401940

-AEBP2chr12

19665332

+
In-frameENST00000539510ENST00000541908ST8SIA1chr12

22401940

-AEBP2chr12

19665332

+
intron-3CDSENST00000381424ENST00000266508ST8SIA1chr12

22401940

-AEBP2chr12

19665332

+
intron-3CDSENST00000381424ENST00000360995ST8SIA1chr12

22401940

-AEBP2chr12

19665332

+
intron-3CDSENST00000381424ENST00000398864ST8SIA1chr12

22401940

-AEBP2chr12

19665332

+
intron-3CDSENST00000381424ENST00000541908ST8SIA1chr12

22401940

-AEBP2chr12

19665332

+
intron-3CDSENST00000404299ENST00000266508ST8SIA1chr12

22401940

-AEBP2chr12

19665332

+
intron-3CDSENST00000404299ENST00000360995ST8SIA1chr12

22401940

-AEBP2chr12

19665332

+
intron-3CDSENST00000404299ENST00000398864ST8SIA1chr12

22401940

-AEBP2chr12

19665332

+
intron-3CDSENST00000404299ENST00000541908ST8SIA1chr12

22401940

-AEBP2chr12

19665332

+
intron-3CDSENST00000536558ENST00000266508ST8SIA1chr12

22401940

-AEBP2chr12

19665332

+
intron-3CDSENST00000536558ENST00000360995ST8SIA1chr12

22401940

-AEBP2chr12

19665332

+
intron-3CDSENST00000536558ENST00000398864ST8SIA1chr12

22401940

-AEBP2chr12

19665332

+
intron-3CDSENST00000536558ENST00000541908ST8SIA1chr12

22401940

-AEBP2chr12

19665332

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000539510ST8SIA1chr1222401940-ENST00000541908AEBP2chr1219665332+72743910372120
ENST00000539510ST8SIA1chr1222401940-ENST00000398864AEBP2chr1219665332+134943910372120
ENST00000539510ST8SIA1chr1222401940-ENST00000266508AEBP2chr1219665332+275943910372120
ENST00000539510ST8SIA1chr1222401940-ENST00000360995AEBP2chr1219665332+219743910372120

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000539510ENST00000541908ST8SIA1chr1222401940-AEBP2chr1219665332+0.107042220.8929578
ENST00000539510ENST00000398864ST8SIA1chr1222401940-AEBP2chr1219665332+0.132388860.86761117
ENST00000539510ENST00000266508ST8SIA1chr1222401940-AEBP2chr1219665332+0.132855420.8671445
ENST00000539510ENST00000360995ST8SIA1chr1222401940-AEBP2chr1219665332+0.189965310.8100347

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Fusion Genomic Features for ST8SIA1-AEBP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ST8SIA1chr1222401939-AEBP2chr1219665331+0.950007260.049992684
ST8SIA1chr1222401939-AEBP2chr1219665331+0.950007260.049992684

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ST8SIA1-AEBP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:19653155/chr12:22354972)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.AEBP2

Q6ZN18

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Acts as an accessory subunit for the core Polycomb repressive complex 2 (PRC2), which mediates histone H3K27 (H3K27me3) trimethylation on chromatin leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:31959557, PubMed:29499137). Plays a role in nucleosome localization of the PRC2 complex (PubMed:29499137). {ECO:0000269|PubMed:15225548, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneST8SIA1chr12:22401940chr12:19665332ENST00000396037-45188_190194357.0RegionSubstrate binding
HgeneST8SIA1chr12:22401940chr12:19665332ENST00000396037-451_29194357.0Topological domainCytoplasmic
HgeneST8SIA1chr12:22401940chr12:19665332ENST00000396037-4530_48194357.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneAEBP2chr12:22401940chr12:19665332ENST0000026650848495_517433504.0RegionImportant for nucleosome binding activity of the PRC2 complex
TgeneAEBP2chr12:22401940chr12:19665332ENST0000036099549495_517217302.0RegionImportant for nucleosome binding activity of the PRC2 complex
TgeneAEBP2chr12:22401940chr12:19665332ENST0000039886449495_517433518.0RegionImportant for nucleosome binding activity of the PRC2 complex
TgeneAEBP2chr12:22401940chr12:19665332ENST0000036099549261_286217302.0Zinc fingerC2H2-type 1
TgeneAEBP2chr12:22401940chr12:19665332ENST0000036099549300_322217302.0Zinc fingerC2H2-type 2%3B degenerate
TgeneAEBP2chr12:22401940chr12:19665332ENST0000036099549328_352217302.0Zinc fingerC2H2-type 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneST8SIA1chr12:22401940chr12:19665332ENST00000396037-45274_276194357.0RegionSubstrate binding
HgeneST8SIA1chr12:22401940chr12:19665332ENST00000396037-4549_356194357.0Topological domainLumenal
TgeneAEBP2chr12:22401940chr12:19665332ENST0000026650848110_256433504.0Compositional biasNote=Ser-rich
TgeneAEBP2chr12:22401940chr12:19665332ENST000002665084834_123433504.0Compositional biasNote=Glu-rich
TgeneAEBP2chr12:22401940chr12:19665332ENST000002665084861_205433504.0Compositional biasNote=Gly-rich
TgeneAEBP2chr12:22401940chr12:19665332ENST0000036099549110_256217302.0Compositional biasNote=Ser-rich
TgeneAEBP2chr12:22401940chr12:19665332ENST000003609954934_123217302.0Compositional biasNote=Glu-rich
TgeneAEBP2chr12:22401940chr12:19665332ENST000003609954961_205217302.0Compositional biasNote=Gly-rich
TgeneAEBP2chr12:22401940chr12:19665332ENST0000039886449110_256433518.0Compositional biasNote=Ser-rich
TgeneAEBP2chr12:22401940chr12:19665332ENST000003988644934_123433518.0Compositional biasNote=Glu-rich
TgeneAEBP2chr12:22401940chr12:19665332ENST000003988644961_205433518.0Compositional biasNote=Gly-rich
TgeneAEBP2chr12:22401940chr12:19665332ENST0000026650848261_286433504.0Zinc fingerC2H2-type 1
TgeneAEBP2chr12:22401940chr12:19665332ENST0000026650848300_322433504.0Zinc fingerC2H2-type 2%3B degenerate
TgeneAEBP2chr12:22401940chr12:19665332ENST0000026650848328_352433504.0Zinc fingerC2H2-type 3
TgeneAEBP2chr12:22401940chr12:19665332ENST0000039886449261_286433518.0Zinc fingerC2H2-type 1
TgeneAEBP2chr12:22401940chr12:19665332ENST0000039886449300_322433518.0Zinc fingerC2H2-type 2%3B degenerate
TgeneAEBP2chr12:22401940chr12:19665332ENST0000039886449328_352433518.0Zinc fingerC2H2-type 3


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Fusion Gene Sequence for ST8SIA1-AEBP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>87042_87042_1_ST8SIA1-AEBP2_ST8SIA1_chr12_22401940_ENST00000539510_AEBP2_chr12_19665332_ENST00000266508_length(transcript)=2759nt_BP=439nt
CAGAGGGGCCATGGCTGTACTGGCGTGGAAGTTCCCGCGGACCCGGCTGCCCATGGGAGCCAGTGCCCTCTGTGTCGTGGTCCTCTGTTG
GCTCTACATCTTCCCCGTCTACCGGCTGCCCAACGAGAAAGAGATCGTGCAGGGGGTGCTGCAACAGGGCACGGCGTGGAGGAGGAACCA
GACCGCGGCCAGAGCGTTCAGGAAACAAATGGAAGACTGCTGCGACCCTGCCCATCTCTTTGCTATGACTAAAATGAATTCCCCTATGGG
GAAGAGCATGTGGTATGACGGGGAGTTTTTATACTCATTCACCATTGACAATTCAACTTACTCTCTCTTCCCACAGATGCAATCTCCCTC
CTTTGTCAAGTGAATACACTAAGGATGTTGGATCCAAAAGTCAGTTAGTGACAGCTAATCCCAGCATAATTCGGCAAAGGTAATAGCTAA
GAGAAAAGAAGATTCTGGGAAGATCAAACTTTTGCTTCATTGGATGCCTGAAGACATTCTGCCTGATGTGTGGGTGAATGAAAGTGAACG
ACATCAGTTAAAAACTAAAGTAGTTCATTTATCAAAGCTACCCAAAGATACTGCCTTGCTTTTGGACCCAAACATATACAGAACAATGCC
GCAGAAGAGGTTGAAGAGGTAAAAAATAAATAAATACATAAAAAGCAAACAAGCGGGGACACCTGCAGTCTTAGTCACTGACAATGGGTT
TAGGGAAAGTTGCACATTAGAGTCAACCCCTTCTTTTTTTTTTTTTTTTTTTTAAATCCAGTATTTAGGATAATATTTATGCTTAGTGTA
AACATTCTGTGAATGAAGTAGACTCTTCGGTGGAATATATTAATATATTACTGTATATCCACATTTTCATGGAATGGTACTGTGGGAGAC
TGAGCAAACACTCTTTTGGCAACTTAGTAGAACAGCTTCTTAAAGGCTTTGCATGCTTGCTGCTTTAAGCTGCTTTTTTTTTTCTTTTCT
TCCCTTTAGTGATTTCAGTAGTTTATATTGGAAAGAAAAACAATTACAACATGTGCCCTTACAAATACCAAAAGCACTGTAAGGATATTT
GTCTTGACAGTGTTTATTGATTTGAAGTCATATTAGGAAATATTTAGACAATGAAAATTATCAAGAGATAATTTACCTTTCAATTATGAT
AAATAGATGTGATTGGTTGCCATTTGTGTTCTTTTGCAGAACTCTGATAAGAAAAGTGTTCAATTTGTATTTAAGCAAACAGTGAACGAC
GTTTGCAATCAACTAAAAATTCGTCTATCGAATTAGGGCTGAAAATTACTGTTAAAGAGTGTTGCAGTATGTCTGGTGGCTCCCTTTTCA
GGACTAGGGCTTTCTCATGGAGTACAGTATGTTAATATTTACCTATATAACTAATCTGTTAACGGTTTTTGAAAAACCTTTCAAATTATT
TGAATAATCTTCATATTTTCATTTAACCTATATGACTCTAATTTTTTTTCTGAGGAAATCATTTGGTTTTTGAGTTGTTTTTTCTTAATG
TAAGAAAAATTGTATTTTTTTTACAAGTATCTTCAAACTGAATCTTTTATGCACCAAAGTTGGTCTTGAAAAGGAAAATAAAATCACTTT
CTTGCTTGGTAAGCAAGAAGCCATATCGATTTTTTTTAACTTACAGAAATGGAAATATGTGTAACTTGTTAGTATTGTATTAAACAAATG
TTGCATAGAGATAATAGAACATTGCTTGTAAATAATTCAGCAGATTTGTAATATATTTTTATATTTTGAAATGTACTGTAGATGTTTTCT
AGAGGCATGAAAGTTAAATGTATATATTATGGTAGAAATAATATTGAAGGATATTGTACTTCACTAGTGCTGCCAGAGGAATTGTTAATA
AAAGCACCTTCTTTAACAATAAATGTCTTTCACAGACTTAAGGGACTATGTACTACTGTTAATATCTCTAAGAACAAAACACATTGAACA
TCCTTCCAGAAAGTCTTTGAGGGAGGACCTATACCCATAATAGAATTATGGCACTCATTTCTGACAGTGATCAAGAAATCAGTTATTTCC
TTACTGTTGGAAGGACATTGTAAAGTATGTGGTTATATGCAGTGAAACTGCAGAAAATACTCCTGGTTGAGGAGTTTTCACTTTACTACA
GTGATATAAAAACCAGCAGTTTTTACACTAAATTTTTTAAAGAAATATTAGACAAAAATATAGAATTAAAACCTTTGGTTCCAAAATGGG
AAAGGTTCCACGATACATAAATCATTTCTCATTTGCTTTAAAAAATTTAAAAGTGTAAAAATTATGAGAGACTTTATTCGTTAACAATGG
GGGTAAAGAGCTATATACATGAAAATGAGTCTTATAAAATTAAGTGAAGTGCAAATAAAAGCACTGCTACTATAAGACATTCTGGAATGG
TTGTTTAATAAGGGTATTATCCATTTGATCTATAGCAATGTGATTTTATTTTTAAAAAGAAAAGCAGTGTGTTTTCTTTTTTTGTTGTTT
TCTTTTGCTTAAGCACTTCATCAATTGCTTTATTCTGTATCTGCGAAGTAATCTGCAATCTCTTTTGTTCTTTTTAAAATTTGATTTGTT
ATAAAATTGCCAAATAGAAGTGTTTCAGATACATAGTTTGTACCTGTATTTTTATTTTATTGCCTCATGTTCTTGTAAGTCATTCTTAAT

>87042_87042_1_ST8SIA1-AEBP2_ST8SIA1_chr12_22401940_ENST00000539510_AEBP2_chr12_19665332_ENST00000266508_length(amino acids)=120AA_BP=
MAVLAWKFPRTRLPMGASALCVVVLCWLYIFPVYRLPNEKEIVQGVLQQGTAWRRNQTAARAFRKQMEDCCDPAHLFAMTKMNSPMGKSM

--------------------------------------------------------------
>87042_87042_2_ST8SIA1-AEBP2_ST8SIA1_chr12_22401940_ENST00000539510_AEBP2_chr12_19665332_ENST00000360995_length(transcript)=2197nt_BP=439nt
CAGAGGGGCCATGGCTGTACTGGCGTGGAAGTTCCCGCGGACCCGGCTGCCCATGGGAGCCAGTGCCCTCTGTGTCGTGGTCCTCTGTTG
GCTCTACATCTTCCCCGTCTACCGGCTGCCCAACGAGAAAGAGATCGTGCAGGGGGTGCTGCAACAGGGCACGGCGTGGAGGAGGAACCA
GACCGCGGCCAGAGCGTTCAGGAAACAAATGGAAGACTGCTGCGACCCTGCCCATCTCTTTGCTATGACTAAAATGAATTCCCCTATGGG
GAAGAGCATGTGGTATGACGGGGAGTTTTTATACTCATTCACCATTGACAATTCAACTTACTCTCTCTTCCCACAGATGCAATCTCCCTC
CTTTGTCAAGTGAATACACTAAGGATGTTGGATCCAAAAGTCAGTTAGTGACAGCTAATCCCAGCATAATTCGGCAAAGGTAATAGCTAA
GAGAAAAGAAGATTCTGGGAAGATCAAACTTTTGCTTCATTGGATGCCTGAAGACATTCTGCCTGATGTGTGGGTGAATGAAAGTGAACG
ACATCAGTTAAAAACTAAAGTAGTTCATTTATCAAAGCTACCCAAAGATACTGCCTTGCTTTTGGACCCAAACATATACAGAACAATGCC
GCAGAAGAGGTTGAAGAGAACTCTGATAAGAAAAGTGTTCAATTTGTATTTAAGCAAACAGTGAACGACGTTTGCAATCAACTAAAAATT
CGTCTATCGAATTAGGGCTGAAAATTACTGTTAAAGAGTGTTGCAGTATGTCTGGTGGCTCCCTTTTCAGGACTAGGGCTTTCTCATGGA
GTACAGTATGTTAATATTTACCTATATAACTAATCTGTTAACGGTTTTTGAAAAACCTTTCAAATTATTTGAATAATCTTCATATTTTCA
TTTAACCTATATGACTCTAATTTTTTTTCTGAGGAAATCATTTGGTTTTTGAGTTGTTTTTTCTTAATGTAAGAAAAATTGTATTTTTTT
TACAAGTATCTTCAAACTGAATCTTTTATGCACCAAAGTTGGTCTTGAAAAGGAAAATAAAATCACTTTCTTGCTTGGTAAGCAAGAAGC
CATATCGATTTTTTTTAACTTACAGAAATGGAAATATGTGTAACTTGTTAGTATTGTATTAAACAAATGTTGCATAGAGATAATAGAACA
TTGCTTGTAAATAATTCAGCAGATTTGTAATATATTTTTATATTTTGAAATGTACTGTAGATGTTTTCTAGAGGCATGAAAGTTAAATGT
ATATATTATGGTAGAAATAATATTGAAGGATATTGTACTTCACTAGTGCTGCCAGAGGAATTGTTAATAAAAGCACCTTCTTTAACAATA
AATGTCTTTCACAGACTTAAGGGACTATGTACTACTGTTAATATCTCTAAGAACAAAACACATTGAACATCCTTCCAGAAAGTCTTTGAG
GGAGGACCTATACCCATAATAGAATTATGGCACTCATTTCTGACAGTGATCAAGAAATCAGTTATTTCCTTACTGTTGGAAGGACATTGT
AAAGTATGTGGTTATATGCAGTGAAACTGCAGAAAATACTCCTGGTTGAGGAGTTTTCACTTTACTACAGTGATATAAAAACCAGCAGTT
TTTACACTAAATTTTTTAAAGAAATATTAGACAAAAATATAGAATTAAAACCTTTGGTTCCAAAATGGGAAAGGTTCCACGATACATAAA
TCATTTCTCATTTGCTTTAAAAAATTTAAAAGTGTAAAAATTATGAGAGACTTTATTCGTTAACAATGGGGGTAAAGAGCTATATACATG
AAAATGAGTCTTATAAAATTAAGTGAAGTGCAAATAAAAGCACTGCTACTATAAGACATTCTGGAATGGTTGTTTAATAAGGGTATTATC
CATTTGATCTATAGCAATGTGATTTTATTTTTAAAAAGAAAAGCAGTGTGTTTTCTTTTTTTGTTGTTTTCTTTTGCTTAAGCACTTCAT
CAATTGCTTTATTCTGTATCTGCGAAGTAATCTGCAATCTCTTTTGTTCTTTTTAAAATTTGATTTGTTATAAAATTGCCAAATAGAAGT
GTTTCAGATACATAGTTTGTACCTGTATTTTTATTTTATTGCCTCATGTTCTTGTAAGTCATTCTTAATTGACCAATGATTGTAGACCTT

>87042_87042_2_ST8SIA1-AEBP2_ST8SIA1_chr12_22401940_ENST00000539510_AEBP2_chr12_19665332_ENST00000360995_length(amino acids)=120AA_BP=
MAVLAWKFPRTRLPMGASALCVVVLCWLYIFPVYRLPNEKEIVQGVLQQGTAWRRNQTAARAFRKQMEDCCDPAHLFAMTKMNSPMGKSM

--------------------------------------------------------------
>87042_87042_3_ST8SIA1-AEBP2_ST8SIA1_chr12_22401940_ENST00000539510_AEBP2_chr12_19665332_ENST00000398864_length(transcript)=1349nt_BP=439nt
CAGAGGGGCCATGGCTGTACTGGCGTGGAAGTTCCCGCGGACCCGGCTGCCCATGGGAGCCAGTGCCCTCTGTGTCGTGGTCCTCTGTTG
GCTCTACATCTTCCCCGTCTACCGGCTGCCCAACGAGAAAGAGATCGTGCAGGGGGTGCTGCAACAGGGCACGGCGTGGAGGAGGAACCA
GACCGCGGCCAGAGCGTTCAGGAAACAAATGGAAGACTGCTGCGACCCTGCCCATCTCTTTGCTATGACTAAAATGAATTCCCCTATGGG
GAAGAGCATGTGGTATGACGGGGAGTTTTTATACTCATTCACCATTGACAATTCAACTTACTCTCTCTTCCCACAGATGCAATCTCCCTC
CTTTGTCAAGTGAATACACTAAGGATGTTGGATCCAAAAGTCAGTTAGTGACAGCTAATCCCAGCATAATTCGGCAAAGGTAATAGCTAA
GAGAAAAGAAGATTCTGGGAAGATCAAACTTTTGCTTCATTGGATGCCTGAAGACATTCTGCCTGATGTGTGGGTGAATGAAAGTGAACG
ACATCAGTTAAAAACTAAAGTAGTTCATTTATCAAAGCTACCCAAAGATACTGCCTTGCTTTTGGACCCAAACATATACAGAACAATGCC
GCAGAAGAGGTTGAAGAGAACTCTGATAAGAAAAGTGTTCAATTTGTATTTAAGCAAACAGTGAACGACGTTTGCAATCAACTAAAAATT
CGTCTATCGAATTAGGGCTGAAAATTACTGTTAAAGAGTGTTGCAGTATGTCTGGTGGCTCCCTTTTCAGGACTAGGGCTTTCTCATGGA
GTACAGTATGTTAATATTTACCTATATAACTAATCTGTTAACGGTTTTTGAAAAACCTTTCAAATTATTTGAATAATCTTCATATTTTCA
TTTAACCTATATGACTCTAATTTTTTTTCTGAGGAAATCATTTGGTTTTTGAGTTGTTTTTTCTTAATGTAAGAAAAATTGTATTTTTTT
TACAAGTATCTTCAAACTGAATCTTTTATGCACCAAAGTTGGTCTTGAAAAGGAAAATAAAATCACTTTCTTGCTTGGTAAGCAAGAAGC
CATATCGATTTTTTTTAACTTACAGAAATGGAAATATGTGTAACTTGTTAGTATTGTATTAAACAAATGTTGCATAGAGATAATAGAACA
TTGCTTGTAAATAATTCAGCAGATTTGTAATATATTTTTATATTTTGAAATGTACTGTAGATGTTTTCTAGAGGCATGAAAGTTAAATGT

>87042_87042_3_ST8SIA1-AEBP2_ST8SIA1_chr12_22401940_ENST00000539510_AEBP2_chr12_19665332_ENST00000398864_length(amino acids)=120AA_BP=
MAVLAWKFPRTRLPMGASALCVVVLCWLYIFPVYRLPNEKEIVQGVLQQGTAWRRNQTAARAFRKQMEDCCDPAHLFAMTKMNSPMGKSM

--------------------------------------------------------------
>87042_87042_4_ST8SIA1-AEBP2_ST8SIA1_chr12_22401940_ENST00000539510_AEBP2_chr12_19665332_ENST00000541908_length(transcript)=727nt_BP=439nt
CAGAGGGGCCATGGCTGTACTGGCGTGGAAGTTCCCGCGGACCCGGCTGCCCATGGGAGCCAGTGCCCTCTGTGTCGTGGTCCTCTGTTG
GCTCTACATCTTCCCCGTCTACCGGCTGCCCAACGAGAAAGAGATCGTGCAGGGGGTGCTGCAACAGGGCACGGCGTGGAGGAGGAACCA
GACCGCGGCCAGAGCGTTCAGGAAACAAATGGAAGACTGCTGCGACCCTGCCCATCTCTTTGCTATGACTAAAATGAATTCCCCTATGGG
GAAGAGCATGTGGTATGACGGGGAGTTTTTATACTCATTCACCATTGACAATTCAACTTACTCTCTCTTCCCACAGATGCAATCTCCCTC
CTTTGTCAAGTGAATACACTAAGGATGTTGGATCCAAAAGTCAGTTAGTGACAGCTAATCCCAGCATAATTCGGCAAAGGTAATAGCTAA
GAGAAAAGAAGATTCTGGGAAGATCAAACTTTTGCTTCATTGGATGCCTGAAGACATTCTGCCTGATGTGTGGGTGAATGAAAGTGAACG
ACATCAGTTAAAAACTAAAGTAGTTCATTTATCAAAGCTACCCAAAGATACTGCCTTGCTTTTGGACCCAAACATATACAGAACAATGCC
GCAGAAGAGGTTGAAGAGGTAAAAAATAAATAAATACATAAAAAGCAAACAAGCGGGGACACCTGCAGTCTTAGTCACTGACAATGGGTT

>87042_87042_4_ST8SIA1-AEBP2_ST8SIA1_chr12_22401940_ENST00000539510_AEBP2_chr12_19665332_ENST00000541908_length(amino acids)=120AA_BP=
MAVLAWKFPRTRLPMGASALCVVVLCWLYIFPVYRLPNEKEIVQGVLQQGTAWRRNQTAARAFRKQMEDCCDPAHLFAMTKMNSPMGKSM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ST8SIA1-AEBP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneAEBP2chr12:22401940chr12:19665332ENST0000036099549407_478217.0302.0SUZ12


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneAEBP2chr12:22401940chr12:19665332ENST0000026650848209_294433.0504.0RBBP4
TgeneAEBP2chr12:22401940chr12:19665332ENST0000036099549209_294217.0302.0RBBP4
TgeneAEBP2chr12:22401940chr12:19665332ENST0000039886449209_294433.0518.0RBBP4
TgeneAEBP2chr12:22401940chr12:19665332ENST0000026650848407_478433.0504.0SUZ12
TgeneAEBP2chr12:22401940chr12:19665332ENST0000039886449407_478433.0518.0SUZ12


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ST8SIA1-AEBP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ST8SIA1-AEBP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource