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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ST8SIA1-FTO (FusionGDB2 ID:87043)

Fusion Gene Summary for ST8SIA1-FTO

check button Fusion gene summary
Fusion gene informationFusion gene name: ST8SIA1-FTO
Fusion gene ID: 87043
HgeneTgene
Gene symbol

ST8SIA1

FTO

Gene ID

6489

79068

Gene nameST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1FTO alpha-ketoglutarate dependent dioxygenase
SynonymsGD3S|SIAT8|SIAT8-A|SIAT8A|ST8SiaIALKBH9|BMIQ14|GDFD
Cytomap

12p12.1

16q12.2

Type of geneprotein-codingprotein-coding
Descriptionalpha-N-acetylneuraminide alpha-2,8-sialyltransferaseST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 1alpha-2,8-sialyltransferase 8Adisialoganglioside (GD3) synthaseganglioside GD3 synthaseganglioside GT3 synthaseganglioside-specific alphaalpha-ketoglutarate-dependent dioxygenase FTOAlkB homolog 9U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTOU6 small nuclear RNA N(6)-methyladenosine-demethylase FTOfat mass and obesity associatedfat mass and obesity-associated protei
Modification date2020031320200329
UniProtAcc.

Q9C0B1

Ensembl transtripts involved in fusion geneENST00000396037, ENST00000539510, 
ENST00000381424, ENST00000404299, 
ENST00000536558, 		ENST00000472835, 
ENST00000471389, ENST00000394647, 
ENST00000431610, ENST00000460382, 
ENST00000463855, 
Fusion gene scores* DoF score10 X 7 X 6=42012 X 10 X 7=840
# samples 1115
** MAII scorelog2(11/420*10)=-1.93288580414146
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/840*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ST8SIA1 [Title/Abstract] AND FTO [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointST8SIA1(22401940)-FTO(54145674), # samples:3
Anticipated loss of major functional domain due to fusion event.ST8SIA1-FTO seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFTO

GO:0006307

DNA dealkylation involved in DNA repair

18775698|20376003

TgeneFTO

GO:0035552

oxidative single-stranded DNA demethylation

18775698|20376003

TgeneFTO

GO:0035553

oxidative single-stranded RNA demethylation

18775698|22002720|25452335|26457839|28002401|30197295

TgeneFTO

GO:0042245

RNA repair

18775698

TgeneFTO

GO:0061157

mRNA destabilization

28002401|30197295

TgeneFTO

GO:0070989

oxidative demethylation

18775698

TgeneFTO

GO:0080111

DNA demethylation

18775698


check buttonFusion gene breakpoints across ST8SIA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FTO (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-TM-A84I-01AST8SIA1chr12

22401940

-FTOchr16

54145674

+
ChimerDB4LGGTCGA-TM-A84IST8SIA1chr12

22401940

-FTOchr16

54145674

+


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Fusion Gene ORF analysis for ST8SIA1-FTO

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000396037ENST00000472835ST8SIA1chr12

22401940

-FTOchr16

54145674

+
5CDS-3UTRENST00000539510ENST00000472835ST8SIA1chr12

22401940

-FTOchr16

54145674

+
Frame-shiftENST00000396037ENST00000471389ST8SIA1chr12

22401940

-FTOchr16

54145674

+
Frame-shiftENST00000539510ENST00000394647ST8SIA1chr12

22401940

-FTOchr16

54145674

+
Frame-shiftENST00000539510ENST00000431610ST8SIA1chr12

22401940

-FTOchr16

54145674

+
Frame-shiftENST00000539510ENST00000460382ST8SIA1chr12

22401940

-FTOchr16

54145674

+
Frame-shiftENST00000539510ENST00000463855ST8SIA1chr12

22401940

-FTOchr16

54145674

+
In-frameENST00000396037ENST00000394647ST8SIA1chr12

22401940

-FTOchr16

54145674

+
In-frameENST00000396037ENST00000431610ST8SIA1chr12

22401940

-FTOchr16

54145674

+
In-frameENST00000396037ENST00000460382ST8SIA1chr12

22401940

-FTOchr16

54145674

+
In-frameENST00000396037ENST00000463855ST8SIA1chr12

22401940

-FTOchr16

54145674

+
In-frameENST00000539510ENST00000471389ST8SIA1chr12

22401940

-FTOchr16

54145674

+
intron-3CDSENST00000381424ENST00000394647ST8SIA1chr12

22401940

-FTOchr16

54145674

+
intron-3CDSENST00000381424ENST00000431610ST8SIA1chr12

22401940

-FTOchr16

54145674

+
intron-3CDSENST00000381424ENST00000460382ST8SIA1chr12

22401940

-FTOchr16

54145674

+
intron-3CDSENST00000381424ENST00000463855ST8SIA1chr12

22401940

-FTOchr16

54145674

+
intron-3CDSENST00000381424ENST00000471389ST8SIA1chr12

22401940

-FTOchr16

54145674

+
intron-3CDSENST00000404299ENST00000394647ST8SIA1chr12

22401940

-FTOchr16

54145674

+
intron-3CDSENST00000404299ENST00000431610ST8SIA1chr12

22401940

-FTOchr16

54145674

+
intron-3CDSENST00000404299ENST00000460382ST8SIA1chr12

22401940

-FTOchr16

54145674

+
intron-3CDSENST00000404299ENST00000463855ST8SIA1chr12

22401940

-FTOchr16

54145674

+
intron-3CDSENST00000404299ENST00000471389ST8SIA1chr12

22401940

-FTOchr16

54145674

+
intron-3CDSENST00000536558ENST00000394647ST8SIA1chr12

22401940

-FTOchr16

54145674

+
intron-3CDSENST00000536558ENST00000431610ST8SIA1chr12

22401940

-FTOchr16

54145674

+
intron-3CDSENST00000536558ENST00000460382ST8SIA1chr12

22401940

-FTOchr16

54145674

+
intron-3CDSENST00000536558ENST00000463855ST8SIA1chr12

22401940

-FTOchr16

54145674

+
intron-3CDSENST00000536558ENST00000471389ST8SIA1chr12

22401940

-FTOchr16

54145674

+
intron-3UTRENST00000381424ENST00000472835ST8SIA1chr12

22401940

-FTOchr16

54145674

+
intron-3UTRENST00000404299ENST00000472835ST8SIA1chr12

22401940

-FTOchr16

54145674

+
intron-3UTRENST00000536558ENST00000472835ST8SIA1chr12

22401940

-FTOchr16

54145674

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000396037ST8SIA1chr1222401940-ENST00000394647FTOchr1654145674+139210664821219245
ENST00000396037ST8SIA1chr1222401940-ENST00000431610FTOchr1654145674+144310664821219245
ENST00000396037ST8SIA1chr1222401940-ENST00000460382FTOchr1654145674+229210664821219245
ENST00000396037ST8SIA1chr1222401940-ENST00000463855FTOchr1654145674+376810664821219245
ENST00000539510ST8SIA1chr1222401940-ENST00000471389FTOchr1654145674+1061943989848571137

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000396037ENST00000394647ST8SIA1chr1222401940-FTOchr1654145674+0.041209390.95879066
ENST00000396037ENST00000431610ST8SIA1chr1222401940-FTOchr1654145674+0.037352360.9626477
ENST00000396037ENST00000460382ST8SIA1chr1222401940-FTOchr1654145674+0.0233708820.9766291
ENST00000396037ENST00000463855ST8SIA1chr1222401940-FTOchr1654145674+0.0103817330.98961824
ENST00000539510ENST00000471389ST8SIA1chr1222401940-FTOchr1654145674+0.1201980860.8798019

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Fusion Genomic Features for ST8SIA1-FTO


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ST8SIA1chr1222401939-FTOchr1654145673+3.82E-050.99996185
ST8SIA1chr1222401939-FTOchr1654145673+3.82E-050.99996185
ST8SIA1chr1222401939-FTOchr1654145673+3.82E-050.99996185
ST8SIA1chr1222401939-FTOchr1654145673+3.82E-050.99996185

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ST8SIA1-FTO


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:22401940/chr16:54145674)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FTO

Q9C0B1

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:22002720, PubMed:26458103, PubMed:28002401, PubMed:30197295, PubMed:26457839, PubMed:25452335). Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:22002720, PubMed:26458103, PubMed:30197295, PubMed:26457839, PubMed:25452335). M6A demethylation by FTO affects mRNA expression and stability (PubMed:30197295). Also able to demethylate m6A in U6 small nuclear RNA (snRNA) (PubMed:30197295). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA (PubMed:28002401, PubMed:30197295). Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping (PubMed:28002401). Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs (PubMed:30197295). Has no activity towards 1-methylguanine (PubMed:20376003). Has no detectable activity towards double-stranded DNA (PubMed:20376003). Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine (PubMed:18775698, PubMed:20376003). Ability to repair alkylated DNA and RNA is however unsure in vivo (PubMed:18775698, PubMed:20376003). Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation (PubMed:18775698, PubMed:20376003). Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (PubMed:26287746). Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (By similarity). Plays an oncogenic role in a number of acute myeloid leukemias by enhancing leukemic oncogene-mediated cell transformation: acts by mediating m6A demethylation of target transcripts such as MYC, CEBPA, ASB2 and RARA, leading to promote their expression (PubMed:28017614, PubMed:29249359). {ECO:0000250|UniProtKB:Q8BGW1, ECO:0000269|PubMed:18775698, ECO:0000269|PubMed:20376003, ECO:0000269|PubMed:22002720, ECO:0000269|PubMed:25452335, ECO:0000269|PubMed:26287746, ECO:0000269|PubMed:26457839, ECO:0000269|PubMed:26458103, ECO:0000269|PubMed:28002401, ECO:0000269|PubMed:28017614, ECO:0000269|PubMed:29249359, ECO:0000269|PubMed:30197295}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneST8SIA1chr12:22401940chr16:54145674ENST00000396037-45188_190194357.0RegionSubstrate binding
HgeneST8SIA1chr12:22401940chr16:54145674ENST00000396037-451_29194357.0Topological domainCytoplasmic
HgeneST8SIA1chr12:22401940chr16:54145674ENST00000396037-4530_48194357.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneFTOchr12:22401940chr16:54145674ENST0000043161035213_22455107.0RegionLoop L1%3B predicted to block binding of double-stranded DNA or RNA
TgeneFTOchr12:22401940chr16:54145674ENST0000043161035231_23455107.0RegionSubstrate binding
TgeneFTOchr12:22401940chr16:54145674ENST0000043161035316_31855107.0RegionAlpha-ketoglutarate binding
TgeneFTOchr12:22401940chr16:54145674ENST0000046038224213_22455107.0RegionLoop L1%3B predicted to block binding of double-stranded DNA or RNA
TgeneFTOchr12:22401940chr16:54145674ENST0000046038224231_23455107.0RegionSubstrate binding
TgeneFTOchr12:22401940chr16:54145674ENST0000046038224316_31855107.0RegionAlpha-ketoglutarate binding
TgeneFTOchr12:22401940chr16:54145674ENST0000046385513213_22476128.0RegionLoop L1%3B predicted to block binding of double-stranded DNA or RNA
TgeneFTOchr12:22401940chr16:54145674ENST0000046385513231_23476128.0RegionSubstrate binding
TgeneFTOchr12:22401940chr16:54145674ENST0000046385513316_31876128.0RegionAlpha-ketoglutarate binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneST8SIA1chr12:22401940chr16:54145674ENST00000396037-45274_276194357.0RegionSubstrate binding
HgeneST8SIA1chr12:22401940chr16:54145674ENST00000396037-4549_356194357.0Topological domainLumenal
TgeneFTOchr12:22401940chr16:54145674ENST000004316103532_32755107.0RegionFe2OG dioxygenase domain
TgeneFTOchr12:22401940chr16:54145674ENST000004603822432_32755107.0RegionFe2OG dioxygenase domain
TgeneFTOchr12:22401940chr16:54145674ENST000004638551332_32776128.0RegionFe2OG dioxygenase domain
TgeneFTOchr12:22401940chr16:54145674ENST0000047138979213_224454506.0RegionLoop L1%3B predicted to block binding of double-stranded DNA or RNA
TgeneFTOchr12:22401940chr16:54145674ENST0000047138979231_234454506.0RegionSubstrate binding
TgeneFTOchr12:22401940chr16:54145674ENST0000047138979316_318454506.0RegionAlpha-ketoglutarate binding
TgeneFTOchr12:22401940chr16:54145674ENST000004713897932_327454506.0RegionFe2OG dioxygenase domain


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Fusion Gene Sequence for ST8SIA1-FTO


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>87043_87043_1_ST8SIA1-FTO_ST8SIA1_chr12_22401940_ENST00000396037_FTO_chr16_54145674_ENST00000394647_length(transcript)=1392nt_BP=1066nt
GGGGGGGGTTGCCTGGCGGCGCAGCAGCGCGGGAGGCGGCGAAGGGCGCAGGAGCATCGCTCGGAGGGGACAAGGGGACGCCACGGGCCA
CATGTTTAGGAGGGAGCCGAGCCTTCTCCCGGACCCTCGCCGAGGGCGACCGTGATGCTGCAGAACCGGCGGGAGCGACTCGCCGCCGCC
GCTCTCTGCGCACTCGGAGACCCCAGCGCCCGCCTTCTGCAGGGGAAGCGACCATGGCCATAGATCGTGACTTCACCCCCAGCCACTTCC
CCTAGAAAGAAATCCTTGGAAAAGTTGCATTTGAAAAAATCCTTGCGCTGACCTTTGGGGCCGACGGGGCCGAAGAAGCGTGCGTGCGTT
TGCAAGTAAGAGAACCAAAGGTGTGTGTGCATGGGGGGCTGGCGGTGGGGGACCCTCCGCTGCCACTTCGCCTAGCTTTGTGCTGAGGCC
CCGGCCCCCGCCCCTGGGACGCCGGGGCTGCGATGAGCCCCTGCGGGCGGGCCCGGCGACAAACGTCCAGAGGGGCCATGGCTGTACTGG
CGTGGAAGTTCCCGCGGACCCGGCTGCCCATGGGAGCCAGTGCCCTCTGTGTCGTGGTCCTCTGTTGGCTCTACATCTTCCCCGTCTACC
GGCTGCCCAACGAGAAAGAGATCGTGCAGGGGGTGCTGCAACAGGGCACGGCGTGGAGGAGGAACCAGACCGCGGCCAGAGCGTTCAGGA
AACAAATGGAAGACTGCTGCGACCCTGCCCATCTCTTTGCTATGACTAAAATGAATTCCCCTATGGGGAAGAGCATGTGGTATGACGGGG
AGTTTTTATACTCATTCACCATTGACAATTCAACTTACTCTCTCTTCCCACAGGCAACCCCATTCCAGCTGCCATTGAAGAAATGCGCGG
TGGTGGGAAATGGTGGGATTCTGAAGAAGAGTGGCTGTGGCCGTCAAATAGATGAAGCAAATTTTGTCATGCGATGCAATCTCCCTCCTT
TGTCAAGTGAATACACTAAGGATGTTGGATCCAAAAGTCAGTTAGTGACAGCTAATCCCAGCATAATTCGGCAAAGGTGCCAGTCACGAA
TTGCCCGAACATTACCTGCTGATCAGAAGCCAGAATGTCGGCCATACTGGGAAAAGGATGATGCTTCGATGCCTCTGCCGTTTGACCTCA
CAGACATCGTTTCAGAACTCAGAGGTCAGCTTCTGGAAGCAAAACCCTAGAAGGAGCACAAGTCTCAGGCGGAGGAGAAAAAGAGATCGG
CTTTTCTCCTCCAACGTTGTCATGGGCTTAAGCAAGAGCAGTGGAGACTTCTCTTGGCCCCTAGATTGTAGCACCCGGGTCCCAATCCAA

>87043_87043_1_ST8SIA1-FTO_ST8SIA1_chr12_22401940_ENST00000396037_FTO_chr16_54145674_ENST00000394647_length(amino acids)=245AA_BP=194
MSPCGRARRQTSRGAMAVLAWKFPRTRLPMGASALCVVVLCWLYIFPVYRLPNEKEIVQGVLQQGTAWRRNQTAARAFRKQMEDCCDPAH
LFAMTKMNSPMGKSMWYDGEFLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLSSEYTKDVGS

--------------------------------------------------------------
>87043_87043_2_ST8SIA1-FTO_ST8SIA1_chr12_22401940_ENST00000396037_FTO_chr16_54145674_ENST00000431610_length(transcript)=1443nt_BP=1066nt
GGGGGGGGTTGCCTGGCGGCGCAGCAGCGCGGGAGGCGGCGAAGGGCGCAGGAGCATCGCTCGGAGGGGACAAGGGGACGCCACGGGCCA
CATGTTTAGGAGGGAGCCGAGCCTTCTCCCGGACCCTCGCCGAGGGCGACCGTGATGCTGCAGAACCGGCGGGAGCGACTCGCCGCCGCC
GCTCTCTGCGCACTCGGAGACCCCAGCGCCCGCCTTCTGCAGGGGAAGCGACCATGGCCATAGATCGTGACTTCACCCCCAGCCACTTCC
CCTAGAAAGAAATCCTTGGAAAAGTTGCATTTGAAAAAATCCTTGCGCTGACCTTTGGGGCCGACGGGGCCGAAGAAGCGTGCGTGCGTT
TGCAAGTAAGAGAACCAAAGGTGTGTGTGCATGGGGGGCTGGCGGTGGGGGACCCTCCGCTGCCACTTCGCCTAGCTTTGTGCTGAGGCC
CCGGCCCCCGCCCCTGGGACGCCGGGGCTGCGATGAGCCCCTGCGGGCGGGCCCGGCGACAAACGTCCAGAGGGGCCATGGCTGTACTGG
CGTGGAAGTTCCCGCGGACCCGGCTGCCCATGGGAGCCAGTGCCCTCTGTGTCGTGGTCCTCTGTTGGCTCTACATCTTCCCCGTCTACC
GGCTGCCCAACGAGAAAGAGATCGTGCAGGGGGTGCTGCAACAGGGCACGGCGTGGAGGAGGAACCAGACCGCGGCCAGAGCGTTCAGGA
AACAAATGGAAGACTGCTGCGACCCTGCCCATCTCTTTGCTATGACTAAAATGAATTCCCCTATGGGGAAGAGCATGTGGTATGACGGGG
AGTTTTTATACTCATTCACCATTGACAATTCAACTTACTCTCTCTTCCCACAGGCAACCCCATTCCAGCTGCCATTGAAGAAATGCGCGG
TGGTGGGAAATGGTGGGATTCTGAAGAAGAGTGGCTGTGGCCGTCAAATAGATGAAGCAAATTTTGTCATGCGATGCAATCTCCCTCCTT
TGTCAAGTGAATACACTAAGGATGTTGGATCCAAAAGTCAGTTAGTGACAGCTAATCCCAGCATAATTCGGCAAAGGTGCCAGTCACGAA
TTGCCCGAACATTACCTGCTGATCAGAAGCCAGAATGTCGGCCATACTGGGAAAAGGATGATGCTTCGATGCCTCTGCCGTTTGACCTCA
CAGACATCGTTTCAGAACTCAGAGGTCAGCTTCTGGAAGCAAAACCCTAGAAGGAGCACAAGTCTCAGGCGGAGGAGAAAAAGAGATCGG
CTTTTCTCCTCCAACGTTGTCATGGGCTTAAGCAAGAGCAGTGGAGACTTCTCTTGGCCCCTAGATTGTAGCACCCGGGTCCCAATCCAA
AACAGCTAGGAAATGGTGCCCATGAAGTTTTAAATGTTTTAAAATGACCCTGTGTTATAGTCTGATTTGGTGTTAAACAGGACCTTCTTC

>87043_87043_2_ST8SIA1-FTO_ST8SIA1_chr12_22401940_ENST00000396037_FTO_chr16_54145674_ENST00000431610_length(amino acids)=245AA_BP=194
MSPCGRARRQTSRGAMAVLAWKFPRTRLPMGASALCVVVLCWLYIFPVYRLPNEKEIVQGVLQQGTAWRRNQTAARAFRKQMEDCCDPAH
LFAMTKMNSPMGKSMWYDGEFLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLSSEYTKDVGS

--------------------------------------------------------------
>87043_87043_3_ST8SIA1-FTO_ST8SIA1_chr12_22401940_ENST00000396037_FTO_chr16_54145674_ENST00000460382_length(transcript)=2292nt_BP=1066nt
GGGGGGGGTTGCCTGGCGGCGCAGCAGCGCGGGAGGCGGCGAAGGGCGCAGGAGCATCGCTCGGAGGGGACAAGGGGACGCCACGGGCCA
CATGTTTAGGAGGGAGCCGAGCCTTCTCCCGGACCCTCGCCGAGGGCGACCGTGATGCTGCAGAACCGGCGGGAGCGACTCGCCGCCGCC
GCTCTCTGCGCACTCGGAGACCCCAGCGCCCGCCTTCTGCAGGGGAAGCGACCATGGCCATAGATCGTGACTTCACCCCCAGCCACTTCC
CCTAGAAAGAAATCCTTGGAAAAGTTGCATTTGAAAAAATCCTTGCGCTGACCTTTGGGGCCGACGGGGCCGAAGAAGCGTGCGTGCGTT
TGCAAGTAAGAGAACCAAAGGTGTGTGTGCATGGGGGGCTGGCGGTGGGGGACCCTCCGCTGCCACTTCGCCTAGCTTTGTGCTGAGGCC
CCGGCCCCCGCCCCTGGGACGCCGGGGCTGCGATGAGCCCCTGCGGGCGGGCCCGGCGACAAACGTCCAGAGGGGCCATGGCTGTACTGG
CGTGGAAGTTCCCGCGGACCCGGCTGCCCATGGGAGCCAGTGCCCTCTGTGTCGTGGTCCTCTGTTGGCTCTACATCTTCCCCGTCTACC
GGCTGCCCAACGAGAAAGAGATCGTGCAGGGGGTGCTGCAACAGGGCACGGCGTGGAGGAGGAACCAGACCGCGGCCAGAGCGTTCAGGA
AACAAATGGAAGACTGCTGCGACCCTGCCCATCTCTTTGCTATGACTAAAATGAATTCCCCTATGGGGAAGAGCATGTGGTATGACGGGG
AGTTTTTATACTCATTCACCATTGACAATTCAACTTACTCTCTCTTCCCACAGGCAACCCCATTCCAGCTGCCATTGAAGAAATGCGCGG
TGGTGGGAAATGGTGGGATTCTGAAGAAGAGTGGCTGTGGCCGTCAAATAGATGAAGCAAATTTTGTCATGCGATGCAATCTCCCTCCTT
TGTCAAGTGAATACACTAAGGATGTTGGATCCAAAAGTCAGTTAGTGACAGCTAATCCCAGCATAATTCGGCAAAGGTGCCAGTCACGAA
TTGCCCGAACATTACCTGCTGATCAGAAGCCAGAATGTCGGCCATACTGGGAAAAGGATGATGCTTCGATGCCTCTGCCGTTTGACCTCA
CAGACATCGTTTCAGAACTCAGAGGTCAGCTTCTGGAAGCAAAACCCTAGAAGGAGCACAAGTCTCAGGCGGAGGAGAAAAAGAGATCGG
CTTTTCTCCTCCAACGTTGTCATGGGCTTAAGCAAGAGCAGTGGAGACTTCTCTTGGCCCCTAGATTGTAGCACCCGGGTCCCAATCCAA
AACAGCTAGGAAATGGTGCCCATGAAGTTTTAAATGTTTTAAAATGACCCTGTGTTATAGTCTGATTTGGTGTTAAACAGGACCTTCTTC
CCCCAAAATTGTTCAGATTATAAAATGTGAGCCATTCAGCCCCCAAGGTCCAGGGCAGGCGACAGGAACGAGCCCAGCGTGTGACAAAGC
CTAACCTACTTTCCTCTTTCCCAAGCTTTTTCAGAGACTCTGGAGTGGACCCAGCCCTCTGGGGAAAGACAGAACTTAGAGACATCCCAG
TTACTCACCACACCCATAGTGCTGTCCAATATGGTAGCCACTAGCTAGCTGTGGCTACTTCAATTTAAATTCAGTTTTAATTTTAATTAA
AAATGCAGCTCTTCAGTCGCCCTGGCCACATTTCAAGTGCTTAACAGCCTCATGTGGCTAGTGACTGCTGTATTGGACGGTACAGATATG
GAACATTTTCATCATCGAAGAAAGTCCTATTGGACAACACTTCTATAAAAAGTTTGAGAGCAGGAATTCTCATTTCCATTCGTCTGTAGC
TTCTATCCCCAAAGGCAAAGAAACTAAAAGAGAAATGACTCATTGAAGATTGGCCTCTTTCCTTTCTCTAAGACAAACCTAAGTAAAAGC
CTGAGCTTTGAGTCCTATGCTCAGCACACGGGAAGGAGATGTTAATAATTAAAATAAAGTTGATATCCTGTCTTTAGGGAGTTCCCTTGA
TCTCTTGAAAGAGACACAGCCCCATTTACATTATTTCGTGGATTTCACCAGCATAGTATAGTTTTTTTCTGTAAGTCCCTCATTCTTATG
TAATAACAGGTGGAACTGAGGTTTGAAGAACCTCAGTGGCCCATCCTGATGACATTGGAGACTCAAAGAGACAAGAGAGAGTAGGGTTTA

>87043_87043_3_ST8SIA1-FTO_ST8SIA1_chr12_22401940_ENST00000396037_FTO_chr16_54145674_ENST00000460382_length(amino acids)=245AA_BP=194
MSPCGRARRQTSRGAMAVLAWKFPRTRLPMGASALCVVVLCWLYIFPVYRLPNEKEIVQGVLQQGTAWRRNQTAARAFRKQMEDCCDPAH
LFAMTKMNSPMGKSMWYDGEFLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLSSEYTKDVGS

--------------------------------------------------------------
>87043_87043_4_ST8SIA1-FTO_ST8SIA1_chr12_22401940_ENST00000396037_FTO_chr16_54145674_ENST00000463855_length(transcript)=3768nt_BP=1066nt
GGGGGGGGTTGCCTGGCGGCGCAGCAGCGCGGGAGGCGGCGAAGGGCGCAGGAGCATCGCTCGGAGGGGACAAGGGGACGCCACGGGCCA
CATGTTTAGGAGGGAGCCGAGCCTTCTCCCGGACCCTCGCCGAGGGCGACCGTGATGCTGCAGAACCGGCGGGAGCGACTCGCCGCCGCC
GCTCTCTGCGCACTCGGAGACCCCAGCGCCCGCCTTCTGCAGGGGAAGCGACCATGGCCATAGATCGTGACTTCACCCCCAGCCACTTCC
CCTAGAAAGAAATCCTTGGAAAAGTTGCATTTGAAAAAATCCTTGCGCTGACCTTTGGGGCCGACGGGGCCGAAGAAGCGTGCGTGCGTT
TGCAAGTAAGAGAACCAAAGGTGTGTGTGCATGGGGGGCTGGCGGTGGGGGACCCTCCGCTGCCACTTCGCCTAGCTTTGTGCTGAGGCC
CCGGCCCCCGCCCCTGGGACGCCGGGGCTGCGATGAGCCCCTGCGGGCGGGCCCGGCGACAAACGTCCAGAGGGGCCATGGCTGTACTGG
CGTGGAAGTTCCCGCGGACCCGGCTGCCCATGGGAGCCAGTGCCCTCTGTGTCGTGGTCCTCTGTTGGCTCTACATCTTCCCCGTCTACC
GGCTGCCCAACGAGAAAGAGATCGTGCAGGGGGTGCTGCAACAGGGCACGGCGTGGAGGAGGAACCAGACCGCGGCCAGAGCGTTCAGGA
AACAAATGGAAGACTGCTGCGACCCTGCCCATCTCTTTGCTATGACTAAAATGAATTCCCCTATGGGGAAGAGCATGTGGTATGACGGGG
AGTTTTTATACTCATTCACCATTGACAATTCAACTTACTCTCTCTTCCCACAGGCAACCCCATTCCAGCTGCCATTGAAGAAATGCGCGG
TGGTGGGAAATGGTGGGATTCTGAAGAAGAGTGGCTGTGGCCGTCAAATAGATGAAGCAAATTTTGTCATGCGATGCAATCTCCCTCCTT
TGTCAAGTGAATACACTAAGGATGTTGGATCCAAAAGTCAGTTAGTGACAGCTAATCCCAGCATAATTCGGCAAAGGTGCCAGTCACGAA
TTGCCCGAACATTACCTGCTGATCAGAAGCCAGAATGTCGGCCATACTGGGAAAAGGATGATGCTTCGATGCCTCTGCCGTTTGACCTCA
CAGACATCGTTTCAGAACTCAGAGGTCAGCTTCTGGAAGCAAAACCCTAGAAGGAGCACAAGTCTCAGGCGGAGGAGAAAAAGAGATCGG
CTTTTCTCCTCCAACGTTGTCATGGGCTTAAGCAAGAGCAGTGGAGACTTCTCTTGGCCCCTAGATTGTAGCACCCGGGTCCCAATCCAA
AACAGCTAGGAAATGGTGCCCATGAAGTTTTAAATGTTTTAAAATGACCCTGTGTTATAGTCTGATTTGGTGTTAAACAGGACCTTCTTC
CCCCAAAATTGTTCAGATTATAAAATGTGAGCCATTCAGCCCCCAAGGTCCAGGGCAGGCGACAGGAACGAGCCCAGCGTGTGACAAAGC
CTAACCTACTTTCCTCTTTCCCAAGCTTTTTCAGAGACTCTGGAGTGGACCCAGCCCTCTGGGGAAAGACAGAACTTAGAGACATCCCAG
TTACTCACCACACCCATAGTGCTGTCCAATATGGTAGCCACTAGCTAGCTGTGGCTACTTCAATTTAAATTCAGTTTTAATTTTAATTAA
AAATGCAGCTCTTCAGTCGCCCTGGCCACATTTCAAGTGCTTAACAGCCTCATGTGGCTAGTGACTGCTGTATTGGACGGTACAGATATG
GAACATTTTCATCATCGAAGAAAGTCCTATTGGACAACACTTCTATAAAAAGTTTGAGAGCAGGAATTCTCATTTCCATTCGTCTGTAGC
TTCTATCCCCAAAGGCAAAGAAACTAAAAGAGAAATGACTCATTGAAGATTGGCCTCTTTCCTTTCTCTAAGACAAACCTAAGTAAAAGC
CTGAGCTTTGAGTCCTATGCTCAGCACACGGGAAGGAGATGTTAATAATTAAAATAAAGTTGATATCCTGTCTTTAGGGAGTTCCCTTGA
TCTCTTGAAAGAGACACAGCCCCATTTACATTATTTCGTGGATTTCACCAGCATAGTATAGTTTTTTTCTGTAAGTCCCTCATTCTTATG
TAATAACAGGTGGAACTGAGGTTTGAAGAACCTCAGTGGCCCATCCTGATGACATTGGAGACTCAAAGAGACAAGAGAGAGTAGGGTTTA
AAACCTGAGCTTTAAGACTCCCACTAGCTTCGTGTCCTTTGGCATGTTAACGTGCCTCAGTTTCCTCATCTGTATAATGGGGATATATGA
AAGGCACCAGTCCTAAGGTGAACATTAAGTGAGATGATTCTAGTTACAGACTTAGAACAATTTCCAGCACATAGTTAAATATCCAGGAAA
TTCTGGTACTGTTATGTGTGGGTGAGCTGACCTGGATGTAGATGTTTTCCTCTCTCTTGCTGACCCCTCCGCCAGTTTTGTCTTGTGATG
CCATTAACACATCTCTCCCTTTCTGACCTGGCTCCTGCCCATTGGTGTCCCAAGAAATCGTGAGAATAGTTAGCCCCCCGTCTCCCCAGC
CTGTTGCTTTCTCGTGTAGTTGTTCACAGTAGTTGAGAAGTTGAAGAGCTTTTGCCTATTGAAGGTGCACTGAGAATAAACTCTTTCCTG
CCACCAGAATTGCAGTGGTTCACGGCCTGCACTCATTCCCATGAATGCAGTTAATAGCCACAGAAATGTCACATTAAGCAAAGCAGCCAG
GGTCTCATCGTGTTGAGACTCGAGTCTCTCAGACCTTGGATTCATTCCCTGGTGTCTTTGAGCCTCAGTTTCCTCATTGGTAAAAGAGAA
GTGAAGCAGTGTCTCACAGGGTCATTACAGAGATTAAATGAAATAAATGAAATAACATAGACCAGGAGGGCGTGGTGTTTAAAAGTCACA
GATGGGGCACCCTCGGGCCATCCAGCCCAGTGTTTTCTTTAGCCCCTATGATGTTCATTTTTTGTTATATCCCATTAGGTGCCCATATTT
AAAAATTGGGAGATTTCACATAAAATTAAAAGGTCTGCATTTTCTTTTTTCTTTTCTTTTTTTTTTTTTTTGAGACACAGTCTCACTCTG
TCACCAGGCTAGAGTGCAGTGGCACGATCTCAGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTAATTCTCCTGCCTCAGCCTCCCAAG
TAGCTGGGACTACAGGCACGTGCCACCACGCCCAGCTAATTTTTGTATTTTTAGCAGAGATGGGGTTTCACCACATTGGCCAGGATGGTC
TCGATCTCAACCTCGTGATCCACCCACCTCGGTCTCCCAAAGCGCTGGGATTACAGGCGTGAGCCACCGCGCCAAGCCAAGGTCTGCATT
TTTCTTTAGAACTCAGAACACCCAATAGTCCTAGGCCCCCATCCTCGCATGGCAGCAAGCTAAATAAGCATCTTCCCACTGCGAGTTGGG
GCATGACCCAGCCTATGGTTTGCCATACTCCCTCTTTTTCTCCGTTTTTTCATTAATTGTGAACCTGACCTGCATCACCCTTTCATGTCA
GTGCTCTCCAAACCTGCTTGCTTGCACCCCTCTAGTCGAAATATTTTGTGCTTACCCCAATATATGTGTGTGACTATTGAACTCTATTCG

>87043_87043_4_ST8SIA1-FTO_ST8SIA1_chr12_22401940_ENST00000396037_FTO_chr16_54145674_ENST00000463855_length(amino acids)=245AA_BP=194
MSPCGRARRQTSRGAMAVLAWKFPRTRLPMGASALCVVVLCWLYIFPVYRLPNEKEIVQGVLQQGTAWRRNQTAARAFRKQMEDCCDPAH
LFAMTKMNSPMGKSMWYDGEFLYSFTIDNSTYSLFPQATPFQLPLKKCAVVGNGGILKKSGCGRQIDEANFVMRCNLPPLSSEYTKDVGS

--------------------------------------------------------------
>87043_87043_5_ST8SIA1-FTO_ST8SIA1_chr12_22401940_ENST00000539510_FTO_chr16_54145674_ENST00000471389_length(transcript)=10619nt_BP=439nt
CAGAGGGGCCATGGCTGTACTGGCGTGGAAGTTCCCGCGGACCCGGCTGCCCATGGGAGCCAGTGCCCTCTGTGTCGTGGTCCTCTGTTG
GCTCTACATCTTCCCCGTCTACCGGCTGCCCAACGAGAAAGAGATCGTGCAGGGGGTGCTGCAACAGGGCACGGCGTGGAGGAGGAACCA
GACCGCGGCCAGAGCGTTCAGGAAACAAATGGAAGACTGCTGCGACCCTGCCCATCTCTTTGCTATGACTAAAATGAATTCCCCTATGGG
GAAGAGCATGTGGTATGACGGGGAGTTTTTATACTCATTCACCATTGACAATTCAACTTACTCTCTCTTCCCACAGATGCAATCTCCCTC
CTTTGTCAAGTGAATACACTAAGGATGTTGGATCCAAAAGTCAGTTAGTGACAGCTAATCCCAGCATAATTCGGCAAAGGTGCCAGTCAC
GAATTGCCCGAACATTACCTGCTGATCAGAAGCCAGAATGTCGGCCATACTGGGAAAAGGATGATGCTTCGATGCCTCTGCCGTTTGACC
TCACAGACATCGTTTCAGAACTCAGAGGTCAGCTTCTGGAAGCAAAACCCTAGAAGGAGCACAAGTCTCAGGCGGAGGAGAAAAAGAGAT
CGGCTTTTCTCCTCCAACGTTGTCATGGGCTTAAGCAAGAGCAGTGGAGACTTCTCTTGGCCCCTAGATTGTAGCACCCGGGTCCCAATC
CAAAACAGCTAGGAAATGGTGCCCATGAAGTTTTAAATGTTTTAAAATGACCCTGTGTTATAGTCTGATTTGGTGTTAAACAGGACCTTC
TTCCCCCAAAATTGTTCAGATTATAAAATGTGAGCCATTCAGCCCCCAAGGTCCAGGGCAGGCGACAGGAACGAGCCCAGCGTGTGACAA
AGCCTAACCTACTTTCCTCTTTCCCAAGCTTTTTCAGAGACTCTGGAGTGGACCCAGCCCTCTGGGGAAAGACAGAACTTAGAGACATCC
CAGTTACTCACCACACCCATAGTGCTGTCCAATATGGTAGCCACTAGCTAGCTGTGGCTACTTCAATTTAAATTCAGTTTTAATTTTAAT
TAAAAATGCAGCTCTTCAGTCGCCCTGGCCACATTTCAAGTGCTTAACAGCCTCATGTGGCTAGTGACTGCTGTATTGGACGGTACAGAT
ATGGAACATTTTCATCATCGAAGAAAGTCCTATTGGACAACACTTCTATAAAAAGTTTGAGAGCAGGAATTCTCATTTCCATTCGTCTGT
AGCTTCTATCCCCAAAGGCAAAGAAACTAAAAGAGAAATGACTCATTGAAGATTGGCCTCTTTCCTTTCTCTAAGACAAACCTAAGTAAA
AGCCTGAGCTTTGAGTCCTATGCTCAGCACACGGGAAGGAGATGTTAATAATTAAAATAAAGTTGATATCCTGTCTTTAGGGAGTTCCCT
TGATCTCTTGAAAGAGACACAGCCCCATTTACATTATTTCGTGGATTTCACCAGCATAGTATAGTTTTTTTCTGTAAGTCCCTCATTCTT
ATGTAATAACAGGTGGAACTGAGGTTTGAAGAACCTCAGTGGCCCATCCTGATGACATTGGAGACTCAAAGAGACAAGAGAGAGTAGGGT
TTAAAACCTGAGCTTTAAGACTCCCACTAGCTTCGTGTCCTTTGGCATGTTAACGTGCCTCAGTTTCCTCATCTGTATAATGGGGATATA
TGAAAGGCACCAGTCCTAAGGTGAACATTAAGTGAGATGATTCTAGTTACAGACTTAGAACAATTTCCAGCACATAGTTAAATATCCAGG
AAATTCTGGTACTGTTATGTGTGGGTGAGCTGACCTGGATGTAGATGTTTTCCTCTCTCTTGCTGACCCCTCCGCCAGTTTTGTCTTGTG
ATGCCATTAACACATCTCTCCCTTTCTGACCTGGCTCCTGCCCATTGGTGTCCCAAGAAATCGTGAGAATAGTTAGCCCCCCGTCTCCCC
AGCCTGTTGCTTTCTCGTGTAGTTGTTCACAGTAGTTGAGAAGTTGAAGAGCTTTTGCCTATTGAAGGTGCACTGAGAATAAACTCTTTC
CTGCCACCAGAATTGCAGTGGTTCACGGCCTGCACTCATTCCCATGAATGCAGTTAATAGCCACAGAAATGTCACATTAAGCAAAGCAGC
CAGGGTCTCATCGTGTTGAGACTCGAGTCTCTCAGACCTTGGATTCATTCCCTGGTGTCTTTGAGCCTCAGTTTCCTCATTGGTAAAAGA
GAAGTGAAGCAGTGTCTCACAGGGTCATTACAGAGATTAAATGAAATAAATGAAATAACATAGACCAGGAGGGCGTGGTGTTTAAAAGTC
ACAGATGGGGCACCCTCGGGCCATCCAGCCCAGTGTTTTCTTTAGCCCCTATGATGTTCATTTTTTGTTATATCCCATTAGGTGCCCATA
TTTAAAAATTGGGAGATTTCACATAAAATTAAAAGGTCTGCATTTTCTTTTTTCTTTTCTTTTTTTTTTTTTTTGAGACACAGTCTCACT
CTGTCACCAGGCTAGAGTGCAGTGGCACGATCTCAGCTCACTGCAACCTCTGCCTCCCAGGTTCAAGTAATTCTCCTGCCTCAGCCTCCC
AAGTAGCTGGGACTACAGGCACGTGCCACCACGCCCAGCTAATTTTTGTATTTTTAGCAGAGATGGGGTTTCACCACATTGGCCAGGATG
GTCTCGATCTCAACCTCGTGATCCACCCACCTCGGTCTCCCAAAGCGCTGGGATTACAGGCGTGAGCCACCGCGCCAAGCCAAGGTCTGC
ATTTTTCTTTAGAACTCAGAACACCCAATAGTCCTAGGCCCCCATCCTCGCATGGCAGCAAGCTAAATAAGCATCTTCCCACTGCGAGTT
GGGGCATGACCCAGCCTATGGTTTGCCATACTCCCTCTTTTTCTCCGTTTTTTCATTAATTGTGAACCTGACCTGCATCACCCTTTCATG
TCAGTGCTCTCCAAACCTGCTTGCTTGCACCCCTCTAGTCGAAATATTTTGTGCTTACCCCAATATATGTGTGTGACTATTGAACTCTAT
TCGTAGACTGCTTGTACTAATGTCATTTGCATCATAAAATATTCATATCCAATAAACATATTAAAAGGATGAGATAAGAAACCGAGAGAT
TTTGCTGTTTTTTTCCTTTTGCATGGATGAGCCAGCTTCACTGTCCTGGGTGGGGCCCAGGTGGAATTAGTTCTCAAAGTCCTCCAGGTG
GAGTCAGGGAATGTGCAACAGGGTTGGAGAAATCACTACTTTAAGTGAATCCGAAAGGTGAGATCACATTTGCTCTAAAGAAATGGTGAT
CCCAGCACTTTGGGAGGCTGAGGCAGCAGATCACTGGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACACGGTGAAACCCCGTCTCTACT
GAAAACACAAAAATTAGCTGGGTGTGGTGGTGTGTGCCTGTAATCCCAGCTACTCGGGAGGCTGAGGCAGGCAAATCGCTTGGCCCGGGA
GGCGGAGGTTGCAGTGAGCCGAGATCATGCCACTGCACTCCAGCCTGGGCCACGGAGCGAGAGAAGAAAGAAATGGTGACTTTCATTGAT
CATGTGTTTGAGGATTTCATGTGCTCTCCAGGGAGGTTTCAGGTGGGTAGAAGGAGGTGGGCAAGACCCAATAAAAAAGCAGCTGGTGCG
GGCAATGACAATGAACTCGTATCCTGCAGGGTCAAAGGAAGGCTTGCTTCTGCTGTGAATTGGAGAAGGACTTTCCTGGAAGCACAGGCC
CAGAAATCGCACCCTTCTCCCCATGTGTGCGGATAAGGGACCACTTCCATCAGCAGCAGCCCCCTCCTGCTTTCCTGCCAGTCCTCCCTG
TGGTCCCAGGTCTCTTGAGAAAAGTGATCTAAGAGATCCCTTTGCAATGAGGTGCTACTGACTGCCCTACCTCCCTCCCTTCCTCCCATG
AATGTTTCTTGGTGCTGACCACAGCCTCAGCAATGAGGCAAGCCTGGGGACCCAAGACAGATCTCTGCCTCCCAGGCTAGTGGATGCCCT
GGGATATGTAGTCACCAAAATAGGAACTTACCCCATAGTGGGGAAATAGACAGTAAGCAGCAAATCAATAACAAGAGTGTTCCAGATGGT
TGTAAGTGCCAGGAAGGGAACCAACTGGGAGAGGGACAAGAGGAGATGGTGACTGACCAAGGGGACCTTGATCAGGCTGTGGGGAAGGGA
GGTGGTTGGGAAGAGCTTCCCAGGAAAGGGGACGGCGGGCCCAGGCAGGAGAGCCTTGGGAGGGGGTGCCCAAGGAAGGAAAAGGGCCCT
GAGCCTGAAGCCGAGAAGACCAGGAGGGGAGAAGGGGAGATGTAGGGCAGAGCAGACGGGAGCCGCTCGGGTTTTATTCCACACACCCCA
GGAAGCATGAGAGGGTTTCAAGCAGCAAGGGCATGGAAGTAACTTGGTGAGATATTTTTATGCATTAGATCATCGCTCTATCTGGATTCC
AGAGGGTCTCTGAGAGAGCAAACAGCTTAATCCAAAGGAGCGGCTTTCCAACTGGGAATGTCCCCCTGGCTGGGTGAGATCTCAAGATGG
CCTGCGGCCCCTCTAGATTGCCTGCCTACAGAGTTCACTCTAAACAGCCCCTCCCCTCCACACCCCAGCAGATCCATTCCTGACGCCCTC
ACTGGCAGGCTCCAGCCCCACAGAGCTTTCTAGACATAAAAGAGCAGGGTCATGGCATCATTGGTGACACAATTTTAGTAATAAGCTTCA
AAACCCATCACTCCACTGAATCCAGGGATGCCAGAATTGAGAGTCCATAGGACCCGTTTAACGGATCCCACATTCAGTAGACGGTTTTTT
GTATGCTTCGAGGGAAGGAAGGTATTTTCAAATGCAACTTCTTTTTTTTTTTTCTTGCTCTAGTTAGGGCTGATTTTACCACTGGGCAAA
TTGCATACATTTGGATCCATGCCACGCTAAAAACTGTTTATTTTGGAGATCTGTCAGAGGCAAGCACATGGAAGACAAGGGGATTCTGGT
TTGAAAAGGCAATTCTCATCCAGACAGATTCAGATGGAGAGGAGCGGTGTGGATTAAAATGCGCCGAAGTGGTAATGCCGTTTATCCCGT
TTGCCTTTGTTACTCTGTGATTAAATGGTATTTTTAATTAAGTTTCATTGGGAGCCATAGGTATCGCGGTGGTGAAATCAATTTGACAAC
CATAAAGGGGAGAGACGGCACAGGCGTGTTGTGATGATTGCGGCTGTAGGGAAAGCCGGGCAGCTTGCAGAGGATGGGTGGGAGGAGGGG
AAGCCGGCTAAGAATGACTTCCTGCAAGACAGCAAGGGCACCCCTGGGCCACTGCTGTGTTTGGGAGGCAGGTTTTGGGGGTTGTCAGAA
GGCATTCACCTGGTTCTCTCGCTCACCTGAGACACCCGATAGATTCCTGGAAACTCCAGGAAAGTATCTGAAGATCTGGTTCTCCATTCT
CTCTTATTAACAAGGAGAACCACAAGTGCCCCCCAGATCCCGGCTAGAAGGACCAGACAGCTTTCCACCCCGGTTCCCAGGCAGCCCTGC
TCCCATAGTCCTGTGTCCCATCGGCCCCATGCTCCCAGGACAGTCCTAATTCCCACCTCTCAGAACCTTGTCAGCCAAGTTCTTCCTGCT
CTCTGGCCCAAATCCTCCTCCTACATTGGAAACTGAGCCTCTCTGCATCCTCTGCTCTTTCTATCCCGCTGTCATTCATCAGATTTTCCA
AATCTTTGGATTCCTGAGTGGCAGAAGAGGTTTTCTGAGTTTAAGTTCTGATTCTGTGTGTGATTCTCACTCTACCACCTCTTCAAACCT
TTGTTGTCTTATCTACAAAATAGAATAGTAGTAATCCATCACCTAAGGTTGTTGTGAAGGTTCAATAAGTTAATGCGTATTTAAAATGCC
TCCCACAGTACCTGACATATACTGGGCTTCAGTGAGGTACTAGCTATTATTATTAACCAAGTTTCCTGTGGTAACAGTTGTAGCTTTGTG
ACTGGGCCAAATCACTTAACCCCTCTGCGCTCCAGTCTTTGTTTCTATAATGGGGATGATGATAATGCCTAGCTCATTGGATTGTTCTGT
CCCCTACGATCAGCCATGTTAAGTGATTCATATCATGTCTGGTACTTAAAAATCACGCCACGCATGTACATTATTATGATGAAAAATATG
ATCCGTGATATCCTGACCAAAATATTAAAGGGACTAAAGATAGCTGTGGCTTGTTCAAGAAGAATATTGTGTCACTATCCCATATATTAT
CCCATTTGCTCTTCACAGCTTCCATTTTTCGCTAGGCGGATGGCATGGAACTTTTTATAAATGAGATATTATGAAAAATGATGTTTTAGG
ACTCTCATTTCTACAGTGGGAGTAGGTCACCCATTGCAATTTTGGATTTGCTTAAAAAAATTCTTGCCATCACCTTCTAATGGATGATCT
GTGTACAACAATTGTTTATTGACTCTGAATGTCTAAGTACCAGGGTCAGTCTATTTCAAGGGGAGGGAAGCATTAATTAACCTCCAGCAT
TAGATTCAGTGATTCTTTTCCAATGATGCAGTTCATGACTTTGCTCGCATTTACTTTTCATCAATCCTGAAAGAATTGAGGTAAAATAGT
TCCTCTGCACATGTGTGTCAAGCTAAATGGATAACAGCAGATACAGATCTGTTTGCCTGTCTGCACTTGCCTTTAGACAAAATTCATCAA
TTTTACAAAAGCCACTGACTAAACATGGCACCAATACAAATGAAGCACTTCTAGCAGGCGGAGATTCCCTTTGTTTCTGATCTGGTAAAT
GCGGTAGTTTCCTGCTGAGAGATGGGAAGTGCTGGCCTAGGACAGCAAGGTGCCCTACAGGTGGGGCCAAAAGGGTCAAGACCGTTCTAC
AGGAAGTTTAGGAGAAGTTCAATGGTTCCAGATCCTGTGTGCTTCGGGTAATTCTGACCCTCTTCATTAGTGATAATGGCATGAAGCTCT
TTCACACAGTCTTTTTTTTTTTTCTTTTTTTTTTTCAGACAGGGTCTCACCCTGTCACGTAGGCTGGAGTGCAGTGGTGAGATCACGGCT
CACTGCAGCCTCGACTTCATGGGCTCAAGCGATTCTCCTGCCTCAGCCTCCTAAGTAGTCGGGATCATAGGCACTTGCCACCACATCCGG
CTAATTTTTTTGTAGAGACAGGATTTCACCACATTACACAGGCTGGTTTCAAACTCCGAGGCTCAAGTGATCTGCCTGCATCGGCCTCCC
AAAGCGCTGAGATTACAAGCGTGAGCCACTACGCCTTGCCCTCCACACAGCCTTGCTTGGTGTTAAAGATTAAACAAAGACCACAGGTGA
TCACTGTCTTCGTGGTGCCAGTTTCAAGGGCACCCTTCTTCCCTTCCCAGCCTCCGAGAGAAGGAGAGAGGGTCCACAAGCCAGATCCAT
CCCCATCCACACAGGTAAAACCACGACTGTGCAGCTAGCAGGTGGAGATAACATTTGGAAAAAGGCTTTGTAAATGCTAAAGTCCTACTC
AAGTCCAAGGGAGAGAAATTATTATTATTCGTTTTGTGAAACCAATTTAGTTTGGCTGGGTAATGGAAGAATTTCTACATACATTCATTA
CTTCTGATCAGGCAAGACCAGTCTGACACAGGAACAGTCTATGGCTCACTCTTAAAGCCACAGCAGGCTGCCAGGGCTTGGAGAAATAGA
AACCTCTCTTGCACAAGAATAGTCTCAATGAATCATGTTAAGGCCTCTTTAGGTTTTTCAGACTCCATGCACCCTGTGGAAACTGCCTTT
CTTGAGTAGAGGTACGTTCAGCACTTCATAAAATAATCTTGGAGCCTCCAGACACACGGATGGAGGAGCATGATTTCATTTGTTTCTTTG
CAAAACTGCTGTCCCCAACTGAAAAACCTGATTATCCTTTCAAATAGGGAATTCGGCTTTCCACGTTGGAACCAGAACAGTTAACCTTCA
AACCCCCAAGGCTTGCAAGAGATGAATCAGTTTCTCAGACAGCCAAAGCCGTGGCTTATAACTCATCCAACCCAGAAAACTGGACCGCTG
GTCACCTTCCTTCCCCCTGCCCCCAACTCTGCAGACAGAGGTTTCCCGTTGATTATGCCTTGATTAGAGTCAGGAGAGAAGCAAACCAGG
TATATAGGATTCCATTATCCTTCCCTCCTCTGCTCCCAACCAGGGTCACGCTGAGAGGGATCTCGGTGAACATGTGAACAATCAAGCCAT
GTTTACCATGGACGTTTAGTTTTCTTTTCTCAAAATCAAAACAGAGTTTAGTAGGCAGCGTATTTCATACATGCCCCTTGATCAATGGAA
TGATCTGTCAGAAGCCATTAAAGCCCCCATTAGCTTGAATGCATTCAAAGCTAAACTATTGGATCATTTAAGGGCTGCAGTGATTGTTTT
TAATATACCGTACATTGATTTCTCCCTGTGAGCAGCAACATAAGTTTGAAACTAACTGTGTATGACTAAGGCTCCATTTGCTGTCTCCAA
CCCTCTGTGAGAAGCATGGTTTCACTTCGACCAGAAATGTCTGTGTATAGTTTTCAAAGAGATGCAGACCCTGTTCGATTTCCCAAGATT
TAGACTGGGTCGGGTTGTTATTTCTTTTTTCCCTGAGCTTTCTCCCATTTCTTTGTGCCCATTAAGTGAGCTGTGCGTGCAGAATGGGAG
AGGCATCCCTGCCAAGGACTTCAAGTGAAAGGCGGTGGGAGAAATTGTTCTGAAAGCATGAAGCCCAGCTGAGGCCAAAATCAAAGTGAA
TTTGACAGCCTTGGGCCAGCAAAACTCTGTACCCAGCAGAAAACAATAGATGTGTGGCTGTGTCAGGGGCATCCTCACTGGGACATAGCT
TGGGGAGCTGAAGGTACCTTGGAAGGGCCAGATGAGGAAGCTAGCCAAGGCCACAGGCCTTCCTTTGACTGCCATATTGCCAGCTCTTCA
TAGTATTGACTCTTCAGTCTTAGCCAACACACACTTGTTGATTCCTTCCGGAATGTCAGACTCTGCTAGCAACACAAGGTCCCTGTCCTC
AAAATCCTATTCTTAATCAGCATTTCTAATTTCTGCCCTTTGCTCATTTTAATACAGAGCCTGAGGATAGGAGAGCAGCGTGGTGAAAGA
AGCAATAGTTACCACATTTGCAAAGGCACATACCCCAAAGAGAAGTTTTTAATATGTCACACCCATATTTTATAGATGGGGCAATGGAAG
TCCAGATGGGAGAAGTTATTTCAGGTGAATTATAGAAACTGGATTTCAAGTTTCTGATAAGTATTGAATTTGGGAAGGCTGTGAACATTC
TTGAGCCCCCCTCCCAAGTTCACCTTCAACATCCTAAAGCAGGTTGAAGAGGAAGATGGTTCCAGGTCACTTACAAGAACAGGAACAGCC
CCTCCCTCCAAATTTGAGCCCAGAAAGGAGAACCTTTGTTACTCTAGAAAACAGTGTGTGTGCTATTGTTTTCTCCATAGGTCACAAACA
TCCACAAGATATTGGTGATTTTACATATTATTAGAGCCACTGAAATTTATGATGCAGGATATTAACGTCAAAGAGGCCAAGATGCATCAT
TCAGAACACTGGCAGGTCAAGCAGAAACCACCGTAGTAAAATTGAAAGCTGGAGTCAGCAAAGTATAGCCCACAGCCAAATCTGGCCCAT
CCCCTGTTCTTATAAAGTTTTATTGGAACGCAGCCATGCTCATCGGTTTATGTATTATCTATGGCTGTTTCCAACTACAGTGGCAGAGCT
GAATAGTTGCAAAGGACCATAGGGCTATCAAAGCCCCAAATAGTCATTGTCTGACCCTTCATAGAAAAATTTTGCTGAACTGTAGTCTAG
CTCCAAGGATTGTTGTATCACCTGTGATCGTGCCTATTAAGCAATTAACGTCATGTCTAGTACTTAGTAATGACTCAGCATGTATCAATT
ACGATGATAAATATTATCATGGCATCCAAACCAAAATACTCATGCCAACATCTCTCTGTACAGAAACATGGAAAAAGAGCGATGCTATTA
AGGAGGAAAATGGAGCCAGGAGCAAAACCTAAGGCTATTTCTGAACTAAAGAGGCCTGAATAAGGTAGTGAAAGGACCAGGGAAAGCCTT
CCCACGGGGATGGAGAGCCACCTCCTCCCCGGCTTTCTGGTTCAGATGTCTTGTCTCAACAGACGGCAGATTCGCAGGGAAGCAGGCCGA
GCCTGATCTTTTCTCCGCTAGAACTGCTCAACAGGTGAAGAATCTTTTTCCAGCACTCCTGAGCCCTTCGGGTCGCGGAACAGTGCGAAG
ATTATTCCAATGCCTCATTCGGAGAGGTGATAATCTGGTCTGTGGTTTCTTTTTCGGTGGGGCATGGGGTGGGGGTGAGTGTCATGCTTT
CTAAGGCACAGGGCTGACTAAAGGGTGTCCTATTTATAAGTCAGTAAAACACAGCGGCTTCATACTCTGTGCTTATTACCCAGAAGCCCC

>87043_87043_5_ST8SIA1-FTO_ST8SIA1_chr12_22401940_ENST00000539510_FTO_chr16_54145674_ENST00000471389_length(amino acids)=137AA_BP=
MAVKGRPVALASFLIWPFQGTFSSPSYVPVRMPLTQPHIYCFLLGTEFCWPKAVKFTLILASAGLHAFRTISPTAFHLKSLAGMPLPFCT

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Fusion Gene PPI Analysis for ST8SIA1-FTO


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ST8SIA1-FTO


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ST8SIA1-FTO


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource