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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:STAG1-SPSB4 (FusionGDB2 ID:87089)

Fusion Gene Summary for STAG1-SPSB4

check button Fusion gene summary
Fusion gene informationFusion gene name: STAG1-SPSB4
Fusion gene ID: 87089
HgeneTgene
Gene symbol

STAG1

SPSB4

Gene ID

56937

92369

Gene nameprostate transmembrane protein, androgen induced 1splA/ryanodine receptor domain and SOCS box containing 4
SynonymsSTAG1|TMEPAISSB-4|SSB4
Cytomap

20q13.31

3q23

Type of geneprotein-codingprotein-coding
Descriptionprotein TMEPAIsolid tumor-associated 1 proteintransmembrane, prostate androgen induced RNASPRY domain-containing SOCS box protein 4SPRY domain-containing SOCS box protein SSB-4
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000236698, ENST00000383202, 
ENST00000434713, ENST00000536929, 
ENST00000480733, 		ENST00000507895, 
ENST00000310546, 
Fusion gene scores* DoF score23 X 21 X 12=57965 X 4 X 4=80
# samples 336
** MAII scorelog2(33/5796*10)=-4.13451966531111
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/80*10)=-0.415037499278844
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STAG1 [Title/Abstract] AND SPSB4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSTAG1(136117591)-SPSB4(140865984), # samples:3
Anticipated loss of major functional domain due to fusion event.STAG1-SPSB4 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
STAG1-SPSB4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTAG1

GO:0010991

negative regulation of SMAD protein complex assembly

20129061

HgeneSTAG1

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

24627487

HgeneSTAG1

GO:0060394

negative regulation of pathway-restricted SMAD protein phosphorylation

24627487

TgeneSPSB4

GO:0006511

ubiquitin-dependent protein catabolic process

21199876

TgeneSPSB4

GO:0016567

protein ubiquitination

21199876

TgeneSPSB4

GO:1902916

positive regulation of protein polyubiquitination

28931592


check buttonFusion gene breakpoints across STAG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SPSB4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-UF-A7JA-01ASTAG1chr3

136117591

-SPSB4chr3

140865984

+
ChimerDB4HNSCTCGA-UF-A7JASTAG1chr3

136117590

-SPSB4chr3

140865983

+
ChimerDB4HNSCTCGA-UF-A7JASTAG1chr3

136117591

-SPSB4chr3

140851031

+
ChimerDB4HNSCTCGA-UF-A7JASTAG1chr3

136117591

-SPSB4chr3

140865984

+


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Fusion Gene ORF analysis for STAG1-SPSB4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000236698ENST00000507895STAG1chr3

136117591

-SPSB4chr3

140865984

+
5CDS-3UTRENST00000236698ENST00000507895STAG1chr3

136117590

-SPSB4chr3

140865983

+
5CDS-3UTRENST00000383202ENST00000507895STAG1chr3

136117591

-SPSB4chr3

140865984

+
5CDS-3UTRENST00000383202ENST00000507895STAG1chr3

136117590

-SPSB4chr3

140865983

+
5CDS-3UTRENST00000434713ENST00000507895STAG1chr3

136117591

-SPSB4chr3

140865984

+
5CDS-3UTRENST00000434713ENST00000507895STAG1chr3

136117590

-SPSB4chr3

140865983

+
5CDS-3UTRENST00000536929ENST00000507895STAG1chr3

136117591

-SPSB4chr3

140865984

+
5CDS-3UTRENST00000536929ENST00000507895STAG1chr3

136117590

-SPSB4chr3

140865983

+
5CDS-intronENST00000236698ENST00000310546STAG1chr3

136117591

-SPSB4chr3

140851031

+
5CDS-intronENST00000236698ENST00000507895STAG1chr3

136117591

-SPSB4chr3

140851031

+
5CDS-intronENST00000383202ENST00000310546STAG1chr3

136117591

-SPSB4chr3

140851031

+
5CDS-intronENST00000383202ENST00000507895STAG1chr3

136117591

-SPSB4chr3

140851031

+
5CDS-intronENST00000434713ENST00000310546STAG1chr3

136117591

-SPSB4chr3

140851031

+
5CDS-intronENST00000434713ENST00000507895STAG1chr3

136117591

-SPSB4chr3

140851031

+
5CDS-intronENST00000536929ENST00000310546STAG1chr3

136117591

-SPSB4chr3

140851031

+
5CDS-intronENST00000536929ENST00000507895STAG1chr3

136117591

-SPSB4chr3

140851031

+
Frame-shiftENST00000434713ENST00000310546STAG1chr3

136117591

-SPSB4chr3

140865984

+
Frame-shiftENST00000434713ENST00000310546STAG1chr3

136117590

-SPSB4chr3

140865983

+
Frame-shiftENST00000536929ENST00000310546STAG1chr3

136117591

-SPSB4chr3

140865984

+
Frame-shiftENST00000536929ENST00000310546STAG1chr3

136117590

-SPSB4chr3

140865983

+
In-frameENST00000236698ENST00000310546STAG1chr3

136117591

-SPSB4chr3

140865984

+
In-frameENST00000236698ENST00000310546STAG1chr3

136117590

-SPSB4chr3

140865983

+
In-frameENST00000383202ENST00000310546STAG1chr3

136117591

-SPSB4chr3

140865984

+
In-frameENST00000383202ENST00000310546STAG1chr3

136117590

-SPSB4chr3

140865983

+
intron-3CDSENST00000480733ENST00000310546STAG1chr3

136117591

-SPSB4chr3

140865984

+
intron-3CDSENST00000480733ENST00000310546STAG1chr3

136117590

-SPSB4chr3

140865983

+
intron-3UTRENST00000480733ENST00000507895STAG1chr3

136117591

-SPSB4chr3

140865984

+
intron-3UTRENST00000480733ENST00000507895STAG1chr3

136117590

-SPSB4chr3

140865983

+
intron-intronENST00000480733ENST00000310546STAG1chr3

136117591

-SPSB4chr3

140851031

+
intron-intronENST00000480733ENST00000507895STAG1chr3

136117591

-SPSB4chr3

140851031

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000383202STAG1chr3136117591-ENST00000310546SPSB4chr3140865984+400425342182551777
ENST00000236698STAG1chr3136117591-ENST00000310546SPSB4chr3140865984+401425442282561777
ENST00000383202STAG1chr3136117590-ENST00000310546SPSB4chr3140865983+400425342182551777
ENST00000236698STAG1chr3136117590-ENST00000310546SPSB4chr3140865983+401425442282561777

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000383202ENST00000310546STAG1chr3136117591-SPSB4chr3140865984+0.0009253450.9990746
ENST00000236698ENST00000310546STAG1chr3136117591-SPSB4chr3140865984+0.0008964660.9991035
ENST00000383202ENST00000310546STAG1chr3136117590-SPSB4chr3140865983+0.0009253450.9990746
ENST00000236698ENST00000310546STAG1chr3136117590-SPSB4chr3140865983+0.0008964660.9991035

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Fusion Genomic Features for STAG1-SPSB4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
STAG1chr3136117590-SPSB4chr3140865983+1.04E-081
STAG1chr3136117590-SPSB4chr3140865983+1.04E-081
STAG1chr3136117590-SPSB4chr3140865983+1.04E-081
STAG1chr3136117590-SPSB4chr3140865983+1.04E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for STAG1-SPSB4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:136117591/chr3:140865984)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTAG1chr3:136117590chr3:140865983ENST00000383202-2234684_6877591259.0Compositional biasNote=Poly-Asp
HgeneSTAG1chr3:136117591chr3:140865984ENST00000383202-2234684_6877591259.0Compositional biasNote=Poly-Asp
HgeneSTAG1chr3:136117590chr3:140865983ENST00000383202-2234296_3817591259.0DomainSCD
HgeneSTAG1chr3:136117591chr3:140865984ENST00000383202-2234296_3817591259.0DomainSCD
TgeneSPSB4chr3:136117590chr3:140865983ENST0000031054613234_273231274.0DomainSOCS box
TgeneSPSB4chr3:136117591chr3:140865984ENST0000031054613234_273231274.0DomainSOCS box

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTAG1chr3:136117590chr3:140865983ENST00000383202-22341065_10707591259.0Compositional biasNote=Poly-Ser
HgeneSTAG1chr3:136117591chr3:140865984ENST00000383202-22341065_10707591259.0Compositional biasNote=Poly-Ser
TgeneSPSB4chr3:136117590chr3:140865983ENST000003105461334_233231274.0DomainB30.2/SPRY
TgeneSPSB4chr3:136117591chr3:140865984ENST000003105461334_233231274.0DomainB30.2/SPRY


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Fusion Gene Sequence for STAG1-SPSB4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>87089_87089_1_STAG1-SPSB4_STAG1_chr3_136117590_ENST00000236698_SPSB4_chr3_140865983_ENST00000310546_length(transcript)=4014nt_BP=2544nt
ATTGGCGTGTGGAAAATGCCACCAGATGGCGGGTTAGGATTGCAGCTCCGTTGAAGGCGCGGCCCCCGCTCCCGAACCCCCGGCGACCAC
CCCGTAACAACCCCCCCACATCGGGAATAACACACCGGAGACTTTTGGGGGGAAACTAGGTCGATGGTCGGCGGCGCCCGGATGGGCAGC
TGAGGATTGCCTTTGAGGTTATTTTAAAAGTTTTGAGTTGTACAGCACTTGATTATTTTGCTGCATTGTGAAAGGACCTCTCCAGCAATG
ATTACTTCAGAATTACCAGTGTTACAGGATTCAACTAATGAAACTACTGCCCATTCCGATGCTGGCAGCGAGCTTGAAGAAACAGAGGTC
AAAGGAAAAAGAAAAAGGGGTCGTCCTGGCCGGCCTCCATCTACAAATAAGAAACCTCGAAAATCTCCAGGTGAGAAGAGCAGAATTGAA
GCTGGAATTAGAGGAGCAGGCCGTGGAAGAGCTAATGGACACCCTCAACAGAATGGGGAAGGGGAGCCTGTCACATTATTTGAGGTGGTG
AAACTGGGGAAAAGTGCAATGCAGTCCGTGGTGGATGACTGGATTGAATCATATAAACAAGACAGGGACATCGCACTTCTGGATTTAATC
AACTTTTTTATCCAGTGTTCAGGATGTCGAGGTACTGTGAGAATAGAGATGTTTCGAAATATGCAGAATGCAGAAATCATCAGAAAAATG
ACTGAAGAATTTGATGAGGACAGTGGTGATTATCCTCTTACCATGCCTGGACCTCAGTGGAAAAAATTTCGTTCAAACTTTTGTGAATTT
ATTGGAGTCCTGATTCGACAGTGTCAGTATAGCATAATTTATGATGAGTATATGATGGACACAGTAATCTCCCTTTTGACGGGTTTGTCA
GACTCCCAGGTCAGAGCTTTTAGGCATACAAGTACCCTGGCTGCCATGAAGCTCATGACTGCTCTGGTGAATGTTGCCTTAAACCTCAGT
ATTCATCAGGATAATACCCAGAGACAATATGAAGCCGAGAGAAATAAAATGATTGGGAAGAGAGCCAATGAAAGGTTGGAGTTACTACTT
CAGAAACGCAAAGAGCTGCAAGAAAATCAGGATGAAATCGAAAATATGATGAACTCTATTTTTAAGGGTATATTTGTTCATAGATACCGT
GATGCTATTGCTGAGATTAGAGCCATTTGTATTGAAGAAATTGGAGTATGGATGAAAATGTATAGTGATGCCTTCCTAAATGACAGTTAC
CTAAAATATGTTGGCTGGACTCTTCATGACAGGCAAGGGGAAGTCAGGCTGAAGTGTTTGAAAGCTCTGCAGAGTCTATATACCAATAGA
GAATTATTCCCCAAATTGGAACTATTCACTAACCGATTCAAGGATCGCATTGTATCAATGACACTTGATAAAGAATATGATGTTGCTGTG
GAAGCTATTCGATTGGTTACTCTGATACTTCATGGAAGTGAAGAAGCTCTTTCCAATGAAGACTGTGAAAATGTTTACCACTTGGTGTAC
TCGGCACATCGCCCTGTTGCTGTGGCAGCTGGAGAGTTCCTTCACAAAAAGCTATTTAGCAGACATGACCCACAAGCAGAAGAAGCATTA
GCAAAGAGGAGGGGAAGAAACAGCCCGAATGGAAACCTCATTAGGATGCTGGTTCTTTTCTTTCTTGAAAGTGAGTTACATGAACATGCA
GCCTACTTGGTGGACAGTTTATGGGAGAGCTCTCAAGAACTGTTGAAAGACTGGGAATGTATGACAGAGTTGCTATTAGAAGAACCTGTT
CAAGGAGAGGAAGCAATGTCTGATCGTCAAGAGAGTGCTCTTATAGAGCTAATGGTTTGTACAATTCGTCAAGCTGCTGAGGCACATCCT
CCAGTGGGAAGGGGTACCGGCAAGAGAGTGCTAACTGCCAAAGAAAGGAAAACTCAAATTGATGATAGAAACAAATTGACTGAACATTTT
ATTATTACACTTCCTATGTTACTGTCAAAGTATTCTGCAGATGCAGAGAAGGTAGCAAACTTGCTACAAATCCCACAGTATTTTGATTTA
GAAATCTACAGCACAGGTAGAATGGAAAAGCATCTGGATGCTTTATTAAAACAGATTAAGTTTGTTGTGGAGAAACACGTAGAATCAGAT
GTTCTAGAAGCCTGCAGTAAAACCTATAGTATCTTATGCAGTGAAGAATATACCATCCAGAACAGAGTTGACATAGCTCGAAGCCAGCTG
ATTGATGAGTTTGTAGATCGATTCAATCATTCTGTGGAAGACCTATTGCAAGAGGGAGAAGAAGCTGATGATGATGACATTTACAATGTT
CTTTCTACATTAAAGCGGTTAACTTCTTTTCACAATGCACATGATCTCACAAAATGGGATCTCTTTGGTAATTGCTACAGATTATTGAAG
ACTGGAATTGAACATGGAGCCATGCCAGAACAGATAGTCGTGCAAGCACTGCAGTGTTCCCATTATTCGATTCTTTGGCAGTTGGTGAAA
ATTACTGATGGCTCTCCTTCCAAACCGAGCCCCTGCCACTGATGGACCTGTGCCGGAGATCCATCCGCTCGGCCCTGGGCCGCCAGCGCC
TGCAGGACATCAGCTCCCTGCCCCTGCCTCAGTCTCTCAAAAACTATCTGCAGTACCAGTGAGCCAAGCCTGATGGGCAGCACAGACACA
GACACACACCGCAGGGCCCGACCCTCCTGTCATTCACAGTCCCATGGCACATAGGGGAAAGGATCTACCCTTCTCCTGGCTCCCCAGGAC
ACTCAGTTCTTTCAAAGACCAGGATGTGGTACCAACTTTGGAAACGAAAGGTCTCTTGCCAACAGTATCTACTGCCCTCGAGGCAGCCCT
CCCAAGTCAGACACCTCCTTCGGAGCCACAGAGAGCCTGGAGTCTGCACCTCCTGGAAATCCTGCCACCAACCAGGACACAGCAGCCACC
GTATTGATCAGAGAGCCTGTTTCCTTATTCAAGAGAATGAATAAAACATTTAGGCAGGAGACTTTCTATTGTGTGCCCCGTTGCAGACAG
GGCCAGGGAGAAATTAGCCAGTGCAGGGGGAAAATTGCCTCTGAATAATGAATGATGAAAGCCTGACGCCGTGCCCCTCCTGGCCCATAC
GCCTTGCCAGGGCGGCAGGATTGTCACACCGTTTTAGGACTCTGTGCCACTTTGAGAGACTGTTCCCAGGAGGCCCAACCGCAGACCTGG
CAAGTGGACAGTGCAGTGTGGAGACACCTTCCGGCTTACCTCTTTGAACGTTGTTTACCTACCCCTTTCCACGTGCTCCCCTTCCCAGCC
ACTGACTCACAGTTCTCTGGATGCCCAGACACCTCTCTTCAGGGAAGATGAGTCTGACTGGTTTGCCCCAGGGAAGAGCATATCCTTACC
ATTATTTTAAGTAGCATTTGCATTTTAAAAGAGGAATGCGGAGAGGACAGTACTTAGTCCAAAGGTGCTAACGGGGGAACTGGGGGCATT
GTGACACCCAAGTCTGATGTGTCCTGGGTTGGGGGGCCTTCCTGGAGTGTCAGGGTCTCTGGGCAACGTCCATTCAGGGTGCGGCATGGC
TGTCACAAAGCTTTATTTGAGCAAATTATTTTTTCACTTTAGGAGACTTCTACAAGTTTGTTTCCTGTTTCAAATGTGTGTGTGATGTGC
TGTTTATTTATCAGCTTGAGGTCCATGGGGGCAGCCTTGTGACTGGAAGGGTGGATATGGGAGACACATTCTCTACCTGCTCCGAGCCTG
GTCCTCTCGCAGGAATGCTGCTGCTGCCTCCGCCGCCACTGCTGCTGCCACCTCTTATATGTTTCAGACACTCTCTGCCCAGACTCATTT
TTAACTGGAAATCATCACAGCAGTGGGATATCAGAGCCCCAGACAGCACTGCCTCTTCCTCCCCACCCCACTGCCCCCACCTTAATGTGA

>87089_87089_1_STAG1-SPSB4_STAG1_chr3_136117590_ENST00000236698_SPSB4_chr3_140865983_ENST00000310546_length(amino acids)=777AA_BP=
MIILLHCERTSPAMITSELPVLQDSTNETTAHSDAGSELEETEVKGKRKRGRPGRPPSTNKKPRKSPGEKSRIEAGIRGAGRGRANGHPQ
QNGEGEPVTLFEVVKLGKSAMQSVVDDWIESYKQDRDIALLDLINFFIQCSGCRGTVRIEMFRNMQNAEIIRKMTEEFDEDSGDYPLTMP
GPQWKKFRSNFCEFIGVLIRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALNLSIHQDNTQRQYEAERNK
MIGKRANERLELLLQKRKELQENQDEIENMMNSIFKGIFVHRYRDAIAEIRAICIEEIGVWMKMYSDAFLNDSYLKYVGWTLHDRQGEVR
LKCLKALQSLYTNRELFPKLELFTNRFKDRIVSMTLDKEYDVAVEAIRLVTLILHGSEEALSNEDCENVYHLVYSAHRPVAVAAGEFLHK
KLFSRHDPQAEEALAKRRGRNSPNGNLIRMLVLFFLESELHEHAAYLVDSLWESSQELLKDWECMTELLLEEPVQGEEAMSDRQESALIE
LMVCTIRQAAEAHPPVGRGTGKRVLTAKERKTQIDDRNKLTEHFIITLPMLLSKYSADAEKVANLLQIPQYFDLEIYSTGRMEKHLDALL
KQIKFVVEKHVESDVLEACSKTYSILCSEEYTIQNRVDIARSQLIDEFVDRFNHSVEDLLQEGEEADDDDIYNVLSTLKRLTSFHNAHDL

--------------------------------------------------------------
>87089_87089_2_STAG1-SPSB4_STAG1_chr3_136117590_ENST00000383202_SPSB4_chr3_140865983_ENST00000310546_length(transcript)=4004nt_BP=2534nt
GGAAAATGCCACCAGATGGCGGGTTAGGATTGCAGCTCCGTTGAAGGCGCGGCCCCCGCTCCCGAACCCCCGGCGACCACCCCGTAACAA
CCCCCCCACATCGGGAATAACACACCGGAGACTTTTGGGGGGAAACTAGGTCGATGGTCGGCGGCGCCCGGATGGGCAGCTGAGGATTGC
CTTTGAGGTTATTTTAAAAGTTTTGAGTTGTACAGCACTTGATTATTTTGCTGCATTGTGAAAGGACCTCTCCAGCAATGATTACTTCAG
AATTACCAGTGTTACAGGATTCAACTAATGAAACTACTGCCCATTCCGATGCTGGCAGCGAGCTTGAAGAAACAGAGGTCAAAGGAAAAA
GAAAAAGGGGTCGTCCTGGCCGGCCTCCATCTACAAATAAGAAACCTCGAAAATCTCCAGGTGAGAAGAGCAGAATTGAAGCTGGAATTA
GAGGAGCAGGCCGTGGAAGAGCTAATGGACACCCTCAACAGAATGGGGAAGGGGAGCCTGTCACATTATTTGAGGTGGTGAAACTGGGGA
AAAGTGCAATGCAGTCCGTGGTGGATGACTGGATTGAATCATATAAACAAGACAGGGACATCGCACTTCTGGATTTAATCAACTTTTTTA
TCCAGTGTTCAGGATGTCGAGGTACTGTGAGAATAGAGATGTTTCGAAATATGCAGAATGCAGAAATCATCAGAAAAATGACTGAAGAAT
TTGATGAGGACAGTGGTGATTATCCTCTTACCATGCCTGGACCTCAGTGGAAAAAATTTCGTTCAAACTTTTGTGAATTTATTGGAGTCC
TGATTCGACAGTGTCAGTATAGCATAATTTATGATGAGTATATGATGGACACAGTAATCTCCCTTTTGACGGGTTTGTCAGACTCCCAGG
TCAGAGCTTTTAGGCATACAAGTACCCTGGCTGCCATGAAGCTCATGACTGCTCTGGTGAATGTTGCCTTAAACCTCAGTATTCATCAGG
ATAATACCCAGAGACAATATGAAGCCGAGAGAAATAAAATGATTGGGAAGAGAGCCAATGAAAGGTTGGAGTTACTACTTCAGAAACGCA
AAGAGCTGCAAGAAAATCAGGATGAAATCGAAAATATGATGAACTCTATTTTTAAGGGTATATTTGTTCATAGATACCGTGATGCTATTG
CTGAGATTAGAGCCATTTGTATTGAAGAAATTGGAGTATGGATGAAAATGTATAGTGATGCCTTCCTAAATGACAGTTACCTAAAATATG
TTGGCTGGACTCTTCATGACAGGCAAGGGGAAGTCAGGCTGAAGTGTTTGAAAGCTCTGCAGAGTCTATATACCAATAGAGAATTATTCC
CCAAATTGGAACTATTCACTAACCGATTCAAGGATCGCATTGTATCAATGACACTTGATAAAGAATATGATGTTGCTGTGGAAGCTATTC
GATTGGTTACTCTGATACTTCATGGAAGTGAAGAAGCTCTTTCCAATGAAGACTGTGAAAATGTTTACCACTTGGTGTACTCGGCACATC
GCCCTGTTGCTGTGGCAGCTGGAGAGTTCCTTCACAAAAAGCTATTTAGCAGACATGACCCACAAGCAGAAGAAGCATTAGCAAAGAGGA
GGGGAAGAAACAGCCCGAATGGAAACCTCATTAGGATGCTGGTTCTTTTCTTTCTTGAAAGTGAGTTACATGAACATGCAGCCTACTTGG
TGGACAGTTTATGGGAGAGCTCTCAAGAACTGTTGAAAGACTGGGAATGTATGACAGAGTTGCTATTAGAAGAACCTGTTCAAGGAGAGG
AAGCAATGTCTGATCGTCAAGAGAGTGCTCTTATAGAGCTAATGGTTTGTACAATTCGTCAAGCTGCTGAGGCACATCCTCCAGTGGGAA
GGGGTACCGGCAAGAGAGTGCTAACTGCCAAAGAAAGGAAAACTCAAATTGATGATAGAAACAAATTGACTGAACATTTTATTATTACAC
TTCCTATGTTACTGTCAAAGTATTCTGCAGATGCAGAGAAGGTAGCAAACTTGCTACAAATCCCACAGTATTTTGATTTAGAAATCTACA
GCACAGGTAGAATGGAAAAGCATCTGGATGCTTTATTAAAACAGATTAAGTTTGTTGTGGAGAAACACGTAGAATCAGATGTTCTAGAAG
CCTGCAGTAAAACCTATAGTATCTTATGCAGTGAAGAATATACCATCCAGAACAGAGTTGACATAGCTCGAAGCCAGCTGATTGATGAGT
TTGTAGATCGATTCAATCATTCTGTGGAAGACCTATTGCAAGAGGGAGAAGAAGCTGATGATGATGACATTTACAATGTTCTTTCTACAT
TAAAGCGGTTAACTTCTTTTCACAATGCACATGATCTCACAAAATGGGATCTCTTTGGTAATTGCTACAGATTATTGAAGACTGGAATTG
AACATGGAGCCATGCCAGAACAGATAGTCGTGCAAGCACTGCAGTGTTCCCATTATTCGATTCTTTGGCAGTTGGTGAAAATTACTGATG
GCTCTCCTTCCAAACCGAGCCCCTGCCACTGATGGACCTGTGCCGGAGATCCATCCGCTCGGCCCTGGGCCGCCAGCGCCTGCAGGACAT
CAGCTCCCTGCCCCTGCCTCAGTCTCTCAAAAACTATCTGCAGTACCAGTGAGCCAAGCCTGATGGGCAGCACAGACACAGACACACACC
GCAGGGCCCGACCCTCCTGTCATTCACAGTCCCATGGCACATAGGGGAAAGGATCTACCCTTCTCCTGGCTCCCCAGGACACTCAGTTCT
TTCAAAGACCAGGATGTGGTACCAACTTTGGAAACGAAAGGTCTCTTGCCAACAGTATCTACTGCCCTCGAGGCAGCCCTCCCAAGTCAG
ACACCTCCTTCGGAGCCACAGAGAGCCTGGAGTCTGCACCTCCTGGAAATCCTGCCACCAACCAGGACACAGCAGCCACCGTATTGATCA
GAGAGCCTGTTTCCTTATTCAAGAGAATGAATAAAACATTTAGGCAGGAGACTTTCTATTGTGTGCCCCGTTGCAGACAGGGCCAGGGAG
AAATTAGCCAGTGCAGGGGGAAAATTGCCTCTGAATAATGAATGATGAAAGCCTGACGCCGTGCCCCTCCTGGCCCATACGCCTTGCCAG
GGCGGCAGGATTGTCACACCGTTTTAGGACTCTGTGCCACTTTGAGAGACTGTTCCCAGGAGGCCCAACCGCAGACCTGGCAAGTGGACA
GTGCAGTGTGGAGACACCTTCCGGCTTACCTCTTTGAACGTTGTTTACCTACCCCTTTCCACGTGCTCCCCTTCCCAGCCACTGACTCAC
AGTTCTCTGGATGCCCAGACACCTCTCTTCAGGGAAGATGAGTCTGACTGGTTTGCCCCAGGGAAGAGCATATCCTTACCATTATTTTAA
GTAGCATTTGCATTTTAAAAGAGGAATGCGGAGAGGACAGTACTTAGTCCAAAGGTGCTAACGGGGGAACTGGGGGCATTGTGACACCCA
AGTCTGATGTGTCCTGGGTTGGGGGGCCTTCCTGGAGTGTCAGGGTCTCTGGGCAACGTCCATTCAGGGTGCGGCATGGCTGTCACAAAG
CTTTATTTGAGCAAATTATTTTTTCACTTTAGGAGACTTCTACAAGTTTGTTTCCTGTTTCAAATGTGTGTGTGATGTGCTGTTTATTTA
TCAGCTTGAGGTCCATGGGGGCAGCCTTGTGACTGGAAGGGTGGATATGGGAGACACATTCTCTACCTGCTCCGAGCCTGGTCCTCTCGC
AGGAATGCTGCTGCTGCCTCCGCCGCCACTGCTGCTGCCACCTCTTATATGTTTCAGACACTCTCTGCCCAGACTCATTTTTAACTGGAA
ATCATCACAGCAGTGGGATATCAGAGCCCCAGACAGCACTGCCTCTTCCTCCCCACCCCACTGCCCCCACCTTAATGTGAATTTGACTGA

>87089_87089_2_STAG1-SPSB4_STAG1_chr3_136117590_ENST00000383202_SPSB4_chr3_140865983_ENST00000310546_length(amino acids)=777AA_BP=
MIILLHCERTSPAMITSELPVLQDSTNETTAHSDAGSELEETEVKGKRKRGRPGRPPSTNKKPRKSPGEKSRIEAGIRGAGRGRANGHPQ
QNGEGEPVTLFEVVKLGKSAMQSVVDDWIESYKQDRDIALLDLINFFIQCSGCRGTVRIEMFRNMQNAEIIRKMTEEFDEDSGDYPLTMP
GPQWKKFRSNFCEFIGVLIRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALNLSIHQDNTQRQYEAERNK
MIGKRANERLELLLQKRKELQENQDEIENMMNSIFKGIFVHRYRDAIAEIRAICIEEIGVWMKMYSDAFLNDSYLKYVGWTLHDRQGEVR
LKCLKALQSLYTNRELFPKLELFTNRFKDRIVSMTLDKEYDVAVEAIRLVTLILHGSEEALSNEDCENVYHLVYSAHRPVAVAAGEFLHK
KLFSRHDPQAEEALAKRRGRNSPNGNLIRMLVLFFLESELHEHAAYLVDSLWESSQELLKDWECMTELLLEEPVQGEEAMSDRQESALIE
LMVCTIRQAAEAHPPVGRGTGKRVLTAKERKTQIDDRNKLTEHFIITLPMLLSKYSADAEKVANLLQIPQYFDLEIYSTGRMEKHLDALL
KQIKFVVEKHVESDVLEACSKTYSILCSEEYTIQNRVDIARSQLIDEFVDRFNHSVEDLLQEGEEADDDDIYNVLSTLKRLTSFHNAHDL

--------------------------------------------------------------
>87089_87089_3_STAG1-SPSB4_STAG1_chr3_136117591_ENST00000236698_SPSB4_chr3_140865984_ENST00000310546_length(transcript)=4014nt_BP=2544nt
ATTGGCGTGTGGAAAATGCCACCAGATGGCGGGTTAGGATTGCAGCTCCGTTGAAGGCGCGGCCCCCGCTCCCGAACCCCCGGCGACCAC
CCCGTAACAACCCCCCCACATCGGGAATAACACACCGGAGACTTTTGGGGGGAAACTAGGTCGATGGTCGGCGGCGCCCGGATGGGCAGC
TGAGGATTGCCTTTGAGGTTATTTTAAAAGTTTTGAGTTGTACAGCACTTGATTATTTTGCTGCATTGTGAAAGGACCTCTCCAGCAATG
ATTACTTCAGAATTACCAGTGTTACAGGATTCAACTAATGAAACTACTGCCCATTCCGATGCTGGCAGCGAGCTTGAAGAAACAGAGGTC
AAAGGAAAAAGAAAAAGGGGTCGTCCTGGCCGGCCTCCATCTACAAATAAGAAACCTCGAAAATCTCCAGGTGAGAAGAGCAGAATTGAA
GCTGGAATTAGAGGAGCAGGCCGTGGAAGAGCTAATGGACACCCTCAACAGAATGGGGAAGGGGAGCCTGTCACATTATTTGAGGTGGTG
AAACTGGGGAAAAGTGCAATGCAGTCCGTGGTGGATGACTGGATTGAATCATATAAACAAGACAGGGACATCGCACTTCTGGATTTAATC
AACTTTTTTATCCAGTGTTCAGGATGTCGAGGTACTGTGAGAATAGAGATGTTTCGAAATATGCAGAATGCAGAAATCATCAGAAAAATG
ACTGAAGAATTTGATGAGGACAGTGGTGATTATCCTCTTACCATGCCTGGACCTCAGTGGAAAAAATTTCGTTCAAACTTTTGTGAATTT
ATTGGAGTCCTGATTCGACAGTGTCAGTATAGCATAATTTATGATGAGTATATGATGGACACAGTAATCTCCCTTTTGACGGGTTTGTCA
GACTCCCAGGTCAGAGCTTTTAGGCATACAAGTACCCTGGCTGCCATGAAGCTCATGACTGCTCTGGTGAATGTTGCCTTAAACCTCAGT
ATTCATCAGGATAATACCCAGAGACAATATGAAGCCGAGAGAAATAAAATGATTGGGAAGAGAGCCAATGAAAGGTTGGAGTTACTACTT
CAGAAACGCAAAGAGCTGCAAGAAAATCAGGATGAAATCGAAAATATGATGAACTCTATTTTTAAGGGTATATTTGTTCATAGATACCGT
GATGCTATTGCTGAGATTAGAGCCATTTGTATTGAAGAAATTGGAGTATGGATGAAAATGTATAGTGATGCCTTCCTAAATGACAGTTAC
CTAAAATATGTTGGCTGGACTCTTCATGACAGGCAAGGGGAAGTCAGGCTGAAGTGTTTGAAAGCTCTGCAGAGTCTATATACCAATAGA
GAATTATTCCCCAAATTGGAACTATTCACTAACCGATTCAAGGATCGCATTGTATCAATGACACTTGATAAAGAATATGATGTTGCTGTG
GAAGCTATTCGATTGGTTACTCTGATACTTCATGGAAGTGAAGAAGCTCTTTCCAATGAAGACTGTGAAAATGTTTACCACTTGGTGTAC
TCGGCACATCGCCCTGTTGCTGTGGCAGCTGGAGAGTTCCTTCACAAAAAGCTATTTAGCAGACATGACCCACAAGCAGAAGAAGCATTA
GCAAAGAGGAGGGGAAGAAACAGCCCGAATGGAAACCTCATTAGGATGCTGGTTCTTTTCTTTCTTGAAAGTGAGTTACATGAACATGCA
GCCTACTTGGTGGACAGTTTATGGGAGAGCTCTCAAGAACTGTTGAAAGACTGGGAATGTATGACAGAGTTGCTATTAGAAGAACCTGTT
CAAGGAGAGGAAGCAATGTCTGATCGTCAAGAGAGTGCTCTTATAGAGCTAATGGTTTGTACAATTCGTCAAGCTGCTGAGGCACATCCT
CCAGTGGGAAGGGGTACCGGCAAGAGAGTGCTAACTGCCAAAGAAAGGAAAACTCAAATTGATGATAGAAACAAATTGACTGAACATTTT
ATTATTACACTTCCTATGTTACTGTCAAAGTATTCTGCAGATGCAGAGAAGGTAGCAAACTTGCTACAAATCCCACAGTATTTTGATTTA
GAAATCTACAGCACAGGTAGAATGGAAAAGCATCTGGATGCTTTATTAAAACAGATTAAGTTTGTTGTGGAGAAACACGTAGAATCAGAT
GTTCTAGAAGCCTGCAGTAAAACCTATAGTATCTTATGCAGTGAAGAATATACCATCCAGAACAGAGTTGACATAGCTCGAAGCCAGCTG
ATTGATGAGTTTGTAGATCGATTCAATCATTCTGTGGAAGACCTATTGCAAGAGGGAGAAGAAGCTGATGATGATGACATTTACAATGTT
CTTTCTACATTAAAGCGGTTAACTTCTTTTCACAATGCACATGATCTCACAAAATGGGATCTCTTTGGTAATTGCTACAGATTATTGAAG
ACTGGAATTGAACATGGAGCCATGCCAGAACAGATAGTCGTGCAAGCACTGCAGTGTTCCCATTATTCGATTCTTTGGCAGTTGGTGAAA
ATTACTGATGGCTCTCCTTCCAAACCGAGCCCCTGCCACTGATGGACCTGTGCCGGAGATCCATCCGCTCGGCCCTGGGCCGCCAGCGCC
TGCAGGACATCAGCTCCCTGCCCCTGCCTCAGTCTCTCAAAAACTATCTGCAGTACCAGTGAGCCAAGCCTGATGGGCAGCACAGACACA
GACACACACCGCAGGGCCCGACCCTCCTGTCATTCACAGTCCCATGGCACATAGGGGAAAGGATCTACCCTTCTCCTGGCTCCCCAGGAC
ACTCAGTTCTTTCAAAGACCAGGATGTGGTACCAACTTTGGAAACGAAAGGTCTCTTGCCAACAGTATCTACTGCCCTCGAGGCAGCCCT
CCCAAGTCAGACACCTCCTTCGGAGCCACAGAGAGCCTGGAGTCTGCACCTCCTGGAAATCCTGCCACCAACCAGGACACAGCAGCCACC
GTATTGATCAGAGAGCCTGTTTCCTTATTCAAGAGAATGAATAAAACATTTAGGCAGGAGACTTTCTATTGTGTGCCCCGTTGCAGACAG
GGCCAGGGAGAAATTAGCCAGTGCAGGGGGAAAATTGCCTCTGAATAATGAATGATGAAAGCCTGACGCCGTGCCCCTCCTGGCCCATAC
GCCTTGCCAGGGCGGCAGGATTGTCACACCGTTTTAGGACTCTGTGCCACTTTGAGAGACTGTTCCCAGGAGGCCCAACCGCAGACCTGG
CAAGTGGACAGTGCAGTGTGGAGACACCTTCCGGCTTACCTCTTTGAACGTTGTTTACCTACCCCTTTCCACGTGCTCCCCTTCCCAGCC
ACTGACTCACAGTTCTCTGGATGCCCAGACACCTCTCTTCAGGGAAGATGAGTCTGACTGGTTTGCCCCAGGGAAGAGCATATCCTTACC
ATTATTTTAAGTAGCATTTGCATTTTAAAAGAGGAATGCGGAGAGGACAGTACTTAGTCCAAAGGTGCTAACGGGGGAACTGGGGGCATT
GTGACACCCAAGTCTGATGTGTCCTGGGTTGGGGGGCCTTCCTGGAGTGTCAGGGTCTCTGGGCAACGTCCATTCAGGGTGCGGCATGGC
TGTCACAAAGCTTTATTTGAGCAAATTATTTTTTCACTTTAGGAGACTTCTACAAGTTTGTTTCCTGTTTCAAATGTGTGTGTGATGTGC
TGTTTATTTATCAGCTTGAGGTCCATGGGGGCAGCCTTGTGACTGGAAGGGTGGATATGGGAGACACATTCTCTACCTGCTCCGAGCCTG
GTCCTCTCGCAGGAATGCTGCTGCTGCCTCCGCCGCCACTGCTGCTGCCACCTCTTATATGTTTCAGACACTCTCTGCCCAGACTCATTT
TTAACTGGAAATCATCACAGCAGTGGGATATCAGAGCCCCAGACAGCACTGCCTCTTCCTCCCCACCCCACTGCCCCCACCTTAATGTGA

>87089_87089_3_STAG1-SPSB4_STAG1_chr3_136117591_ENST00000236698_SPSB4_chr3_140865984_ENST00000310546_length(amino acids)=777AA_BP=
MIILLHCERTSPAMITSELPVLQDSTNETTAHSDAGSELEETEVKGKRKRGRPGRPPSTNKKPRKSPGEKSRIEAGIRGAGRGRANGHPQ
QNGEGEPVTLFEVVKLGKSAMQSVVDDWIESYKQDRDIALLDLINFFIQCSGCRGTVRIEMFRNMQNAEIIRKMTEEFDEDSGDYPLTMP
GPQWKKFRSNFCEFIGVLIRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALNLSIHQDNTQRQYEAERNK
MIGKRANERLELLLQKRKELQENQDEIENMMNSIFKGIFVHRYRDAIAEIRAICIEEIGVWMKMYSDAFLNDSYLKYVGWTLHDRQGEVR
LKCLKALQSLYTNRELFPKLELFTNRFKDRIVSMTLDKEYDVAVEAIRLVTLILHGSEEALSNEDCENVYHLVYSAHRPVAVAAGEFLHK
KLFSRHDPQAEEALAKRRGRNSPNGNLIRMLVLFFLESELHEHAAYLVDSLWESSQELLKDWECMTELLLEEPVQGEEAMSDRQESALIE
LMVCTIRQAAEAHPPVGRGTGKRVLTAKERKTQIDDRNKLTEHFIITLPMLLSKYSADAEKVANLLQIPQYFDLEIYSTGRMEKHLDALL
KQIKFVVEKHVESDVLEACSKTYSILCSEEYTIQNRVDIARSQLIDEFVDRFNHSVEDLLQEGEEADDDDIYNVLSTLKRLTSFHNAHDL

--------------------------------------------------------------
>87089_87089_4_STAG1-SPSB4_STAG1_chr3_136117591_ENST00000383202_SPSB4_chr3_140865984_ENST00000310546_length(transcript)=4004nt_BP=2534nt
GGAAAATGCCACCAGATGGCGGGTTAGGATTGCAGCTCCGTTGAAGGCGCGGCCCCCGCTCCCGAACCCCCGGCGACCACCCCGTAACAA
CCCCCCCACATCGGGAATAACACACCGGAGACTTTTGGGGGGAAACTAGGTCGATGGTCGGCGGCGCCCGGATGGGCAGCTGAGGATTGC
CTTTGAGGTTATTTTAAAAGTTTTGAGTTGTACAGCACTTGATTATTTTGCTGCATTGTGAAAGGACCTCTCCAGCAATGATTACTTCAG
AATTACCAGTGTTACAGGATTCAACTAATGAAACTACTGCCCATTCCGATGCTGGCAGCGAGCTTGAAGAAACAGAGGTCAAAGGAAAAA
GAAAAAGGGGTCGTCCTGGCCGGCCTCCATCTACAAATAAGAAACCTCGAAAATCTCCAGGTGAGAAGAGCAGAATTGAAGCTGGAATTA
GAGGAGCAGGCCGTGGAAGAGCTAATGGACACCCTCAACAGAATGGGGAAGGGGAGCCTGTCACATTATTTGAGGTGGTGAAACTGGGGA
AAAGTGCAATGCAGTCCGTGGTGGATGACTGGATTGAATCATATAAACAAGACAGGGACATCGCACTTCTGGATTTAATCAACTTTTTTA
TCCAGTGTTCAGGATGTCGAGGTACTGTGAGAATAGAGATGTTTCGAAATATGCAGAATGCAGAAATCATCAGAAAAATGACTGAAGAAT
TTGATGAGGACAGTGGTGATTATCCTCTTACCATGCCTGGACCTCAGTGGAAAAAATTTCGTTCAAACTTTTGTGAATTTATTGGAGTCC
TGATTCGACAGTGTCAGTATAGCATAATTTATGATGAGTATATGATGGACACAGTAATCTCCCTTTTGACGGGTTTGTCAGACTCCCAGG
TCAGAGCTTTTAGGCATACAAGTACCCTGGCTGCCATGAAGCTCATGACTGCTCTGGTGAATGTTGCCTTAAACCTCAGTATTCATCAGG
ATAATACCCAGAGACAATATGAAGCCGAGAGAAATAAAATGATTGGGAAGAGAGCCAATGAAAGGTTGGAGTTACTACTTCAGAAACGCA
AAGAGCTGCAAGAAAATCAGGATGAAATCGAAAATATGATGAACTCTATTTTTAAGGGTATATTTGTTCATAGATACCGTGATGCTATTG
CTGAGATTAGAGCCATTTGTATTGAAGAAATTGGAGTATGGATGAAAATGTATAGTGATGCCTTCCTAAATGACAGTTACCTAAAATATG
TTGGCTGGACTCTTCATGACAGGCAAGGGGAAGTCAGGCTGAAGTGTTTGAAAGCTCTGCAGAGTCTATATACCAATAGAGAATTATTCC
CCAAATTGGAACTATTCACTAACCGATTCAAGGATCGCATTGTATCAATGACACTTGATAAAGAATATGATGTTGCTGTGGAAGCTATTC
GATTGGTTACTCTGATACTTCATGGAAGTGAAGAAGCTCTTTCCAATGAAGACTGTGAAAATGTTTACCACTTGGTGTACTCGGCACATC
GCCCTGTTGCTGTGGCAGCTGGAGAGTTCCTTCACAAAAAGCTATTTAGCAGACATGACCCACAAGCAGAAGAAGCATTAGCAAAGAGGA
GGGGAAGAAACAGCCCGAATGGAAACCTCATTAGGATGCTGGTTCTTTTCTTTCTTGAAAGTGAGTTACATGAACATGCAGCCTACTTGG
TGGACAGTTTATGGGAGAGCTCTCAAGAACTGTTGAAAGACTGGGAATGTATGACAGAGTTGCTATTAGAAGAACCTGTTCAAGGAGAGG
AAGCAATGTCTGATCGTCAAGAGAGTGCTCTTATAGAGCTAATGGTTTGTACAATTCGTCAAGCTGCTGAGGCACATCCTCCAGTGGGAA
GGGGTACCGGCAAGAGAGTGCTAACTGCCAAAGAAAGGAAAACTCAAATTGATGATAGAAACAAATTGACTGAACATTTTATTATTACAC
TTCCTATGTTACTGTCAAAGTATTCTGCAGATGCAGAGAAGGTAGCAAACTTGCTACAAATCCCACAGTATTTTGATTTAGAAATCTACA
GCACAGGTAGAATGGAAAAGCATCTGGATGCTTTATTAAAACAGATTAAGTTTGTTGTGGAGAAACACGTAGAATCAGATGTTCTAGAAG
CCTGCAGTAAAACCTATAGTATCTTATGCAGTGAAGAATATACCATCCAGAACAGAGTTGACATAGCTCGAAGCCAGCTGATTGATGAGT
TTGTAGATCGATTCAATCATTCTGTGGAAGACCTATTGCAAGAGGGAGAAGAAGCTGATGATGATGACATTTACAATGTTCTTTCTACAT
TAAAGCGGTTAACTTCTTTTCACAATGCACATGATCTCACAAAATGGGATCTCTTTGGTAATTGCTACAGATTATTGAAGACTGGAATTG
AACATGGAGCCATGCCAGAACAGATAGTCGTGCAAGCACTGCAGTGTTCCCATTATTCGATTCTTTGGCAGTTGGTGAAAATTACTGATG
GCTCTCCTTCCAAACCGAGCCCCTGCCACTGATGGACCTGTGCCGGAGATCCATCCGCTCGGCCCTGGGCCGCCAGCGCCTGCAGGACAT
CAGCTCCCTGCCCCTGCCTCAGTCTCTCAAAAACTATCTGCAGTACCAGTGAGCCAAGCCTGATGGGCAGCACAGACACAGACACACACC
GCAGGGCCCGACCCTCCTGTCATTCACAGTCCCATGGCACATAGGGGAAAGGATCTACCCTTCTCCTGGCTCCCCAGGACACTCAGTTCT
TTCAAAGACCAGGATGTGGTACCAACTTTGGAAACGAAAGGTCTCTTGCCAACAGTATCTACTGCCCTCGAGGCAGCCCTCCCAAGTCAG
ACACCTCCTTCGGAGCCACAGAGAGCCTGGAGTCTGCACCTCCTGGAAATCCTGCCACCAACCAGGACACAGCAGCCACCGTATTGATCA
GAGAGCCTGTTTCCTTATTCAAGAGAATGAATAAAACATTTAGGCAGGAGACTTTCTATTGTGTGCCCCGTTGCAGACAGGGCCAGGGAG
AAATTAGCCAGTGCAGGGGGAAAATTGCCTCTGAATAATGAATGATGAAAGCCTGACGCCGTGCCCCTCCTGGCCCATACGCCTTGCCAG
GGCGGCAGGATTGTCACACCGTTTTAGGACTCTGTGCCACTTTGAGAGACTGTTCCCAGGAGGCCCAACCGCAGACCTGGCAAGTGGACA
GTGCAGTGTGGAGACACCTTCCGGCTTACCTCTTTGAACGTTGTTTACCTACCCCTTTCCACGTGCTCCCCTTCCCAGCCACTGACTCAC
AGTTCTCTGGATGCCCAGACACCTCTCTTCAGGGAAGATGAGTCTGACTGGTTTGCCCCAGGGAAGAGCATATCCTTACCATTATTTTAA
GTAGCATTTGCATTTTAAAAGAGGAATGCGGAGAGGACAGTACTTAGTCCAAAGGTGCTAACGGGGGAACTGGGGGCATTGTGACACCCA
AGTCTGATGTGTCCTGGGTTGGGGGGCCTTCCTGGAGTGTCAGGGTCTCTGGGCAACGTCCATTCAGGGTGCGGCATGGCTGTCACAAAG
CTTTATTTGAGCAAATTATTTTTTCACTTTAGGAGACTTCTACAAGTTTGTTTCCTGTTTCAAATGTGTGTGTGATGTGCTGTTTATTTA
TCAGCTTGAGGTCCATGGGGGCAGCCTTGTGACTGGAAGGGTGGATATGGGAGACACATTCTCTACCTGCTCCGAGCCTGGTCCTCTCGC
AGGAATGCTGCTGCTGCCTCCGCCGCCACTGCTGCTGCCACCTCTTATATGTTTCAGACACTCTCTGCCCAGACTCATTTTTAACTGGAA
ATCATCACAGCAGTGGGATATCAGAGCCCCAGACAGCACTGCCTCTTCCTCCCCACCCCACTGCCCCCACCTTAATGTGAATTTGACTGA

>87089_87089_4_STAG1-SPSB4_STAG1_chr3_136117591_ENST00000383202_SPSB4_chr3_140865984_ENST00000310546_length(amino acids)=777AA_BP=
MIILLHCERTSPAMITSELPVLQDSTNETTAHSDAGSELEETEVKGKRKRGRPGRPPSTNKKPRKSPGEKSRIEAGIRGAGRGRANGHPQ
QNGEGEPVTLFEVVKLGKSAMQSVVDDWIESYKQDRDIALLDLINFFIQCSGCRGTVRIEMFRNMQNAEIIRKMTEEFDEDSGDYPLTMP
GPQWKKFRSNFCEFIGVLIRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTALVNVALNLSIHQDNTQRQYEAERNK
MIGKRANERLELLLQKRKELQENQDEIENMMNSIFKGIFVHRYRDAIAEIRAICIEEIGVWMKMYSDAFLNDSYLKYVGWTLHDRQGEVR
LKCLKALQSLYTNRELFPKLELFTNRFKDRIVSMTLDKEYDVAVEAIRLVTLILHGSEEALSNEDCENVYHLVYSAHRPVAVAAGEFLHK
KLFSRHDPQAEEALAKRRGRNSPNGNLIRMLVLFFLESELHEHAAYLVDSLWESSQELLKDWECMTELLLEEPVQGEEAMSDRQESALIE
LMVCTIRQAAEAHPPVGRGTGKRVLTAKERKTQIDDRNKLTEHFIITLPMLLSKYSADAEKVANLLQIPQYFDLEIYSTGRMEKHLDALL
KQIKFVVEKHVESDVLEACSKTYSILCSEEYTIQNRVDIARSQLIDEFVDRFNHSVEDLLQEGEEADDDDIYNVLSTLKRLTSFHNAHDL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for STAG1-SPSB4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for STAG1-SPSB4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for STAG1-SPSB4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource