FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:B3GNTL1-ARHGAP44 (FusionGDB2 ID:8713)

Fusion Gene Summary for B3GNTL1-ARHGAP44

check button Fusion gene summary
Fusion gene informationFusion gene name: B3GNTL1-ARHGAP44
Fusion gene ID: 8713
HgeneTgene
Gene symbol

B3GNTL1

ARHGAP44

Gene ID

146712

9912

Gene nameUDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase like 1Rho GTPase activating protein 44
Synonyms3-Gn-T8|B3GNT8|BGnT-8|beta-1|beta3Gn-T8|beta3GnTL1NPC-A-10|RICH2
Cytomap

17q25.3

17p12

Type of geneprotein-codingprotein-coding
DescriptionUDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1BGnT-like protein 1UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8beta-1,3-Gn-T8beta-1,3-N-acetylglucosaminyltransferase 8beta1,3-N-acetylglucosaminyltransferase-rho GTPase-activating protein 44Rho-type GTPase-activating protein RICH2RhoGAP interacting with CIP4 homologs protein 2rho GTPase-activating protein RICH2
Modification date2020031320200313
UniProtAcc

Q67FW5

Q17R89

Ensembl transtripts involved in fusion geneENST00000320865, ENST00000576599, 
ENST00000571954, 		ENST00000578087, 
ENST00000262444, ENST00000340825, 
ENST00000379672, 
Fusion gene scores* DoF score6 X 5 X 3=909 X 9 X 7=567
# samples 611
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/567*10)=-2.36584521141757
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: B3GNTL1 [Title/Abstract] AND ARHGAP44 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointB3GNTL1(80962991)-ARHGAP44(12798257), # samples:1
Anticipated loss of major functional domain due to fusion event.B3GNTL1-ARHGAP44 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
B3GNTL1-ARHGAP44 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
B3GNTL1-ARHGAP44 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across B3GNTL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ARHGAP44 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A1B0-01AB3GNTL1chr17

80962991

-ARHGAP44chr17

12798257

+


Top

Fusion Gene ORF analysis for B3GNTL1-ARHGAP44

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000320865ENST00000578087B3GNTL1chr17

80962991

-ARHGAP44chr17

12798257

+
5CDS-intronENST00000576599ENST00000578087B3GNTL1chr17

80962991

-ARHGAP44chr17

12798257

+
5UTR-3CDSENST00000571954ENST00000262444B3GNTL1chr17

80962991

-ARHGAP44chr17

12798257

+
5UTR-3CDSENST00000571954ENST00000340825B3GNTL1chr17

80962991

-ARHGAP44chr17

12798257

+
5UTR-3CDSENST00000571954ENST00000379672B3GNTL1chr17

80962991

-ARHGAP44chr17

12798257

+
5UTR-intronENST00000571954ENST00000578087B3GNTL1chr17

80962991

-ARHGAP44chr17

12798257

+
Frame-shiftENST00000320865ENST00000262444B3GNTL1chr17

80962991

-ARHGAP44chr17

12798257

+
Frame-shiftENST00000320865ENST00000340825B3GNTL1chr17

80962991

-ARHGAP44chr17

12798257

+
Frame-shiftENST00000320865ENST00000379672B3GNTL1chr17

80962991

-ARHGAP44chr17

12798257

+
In-frameENST00000576599ENST00000262444B3GNTL1chr17

80962991

-ARHGAP44chr17

12798257

+
In-frameENST00000576599ENST00000340825B3GNTL1chr17

80962991

-ARHGAP44chr17

12798257

+
In-frameENST00000576599ENST00000379672B3GNTL1chr17

80962991

-ARHGAP44chr17

12798257

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000576599B3GNTL1chr1780962991-ENST00000379672ARHGAP44chr1712798257+47979229413325794
ENST00000576599B3GNTL1chr1780962991-ENST00000340825ARHGAP44chr1712798257+47809229413307788
ENST00000576599B3GNTL1chr1780962991-ENST00000262444ARHGAP44chr1712798257+37919229413193750

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000576599ENST00000379672B3GNTL1chr1780962991-ARHGAP44chr1712798257+0.0070650960.9929349
ENST00000576599ENST00000340825B3GNTL1chr1780962991-ARHGAP44chr1712798257+0.0064128330.99358714
ENST00000576599ENST00000262444B3GNTL1chr1780962991-ARHGAP44chr1712798257+0.0150069360.9849931

Top

Fusion Genomic Features for B3GNTL1-ARHGAP44


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
B3GNTL1chr1780962990-ARHGAP44chr1712798256+0.152160930.84783906
B3GNTL1chr1780962990-ARHGAP44chr1712798256+0.152160930.84783906

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for B3GNTL1-ARHGAP44


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:80962991/chr17:12798257)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
B3GNTL1

Q67FW5

ARHGAP44

Q17R89

FUNCTION: Putative glycosyltransferase. {ECO:0000305}.FUNCTION: GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed:11431473). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (By similarity). Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation (By similarity). In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation (By similarity). {ECO:0000250|UniProtKB:F1LQX4, ECO:0000250|UniProtKB:Q5SSM3, ECO:0000269|PubMed:11431473}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneARHGAP44chr17:80962991chr17:12798257ENST00000379672021255_44517819.0DomainRho-GAP
TgeneARHGAP44chr17:80962991chr17:12798257ENST00000379672021815_81817819.0MotifPDZ-binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneARHGAP44chr17:80962991chr17:12798257ENST0000037967202114_24917819.0DomainBAR


Top

Fusion Gene Sequence for B3GNTL1-ARHGAP44


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8713_8713_1_B3GNTL1-ARHGAP44_B3GNTL1_chr17_80962991_ENST00000576599_ARHGAP44_chr17_12798257_ENST00000262444_length(transcript)=3791nt_BP=922nt
ATTCTCCCGCCTCAGCTTCCCGAGTAGCTGGGACTACAGGAGCCTGCCACCACGCCTGGCTAATTTTTTGTATTTTTAGTAGAGATGGGG
TTTCACCATGTTAGCCAGGATGGTCTCAATCTCCTGACCTTGTAATCCACCCACCTCGGCCTCCCAAAGTCCTTTCAGTTTTTTTTTCAC
TTTCAAAAACATGTAGAAGGCAGTTCAGGGAAAGCTAAGACGTAAAGAATCTTACAAGCATGTTAAGAGCCTGGAGAAAAGGAGTGGACA
CCTTTTGTTTGTCACGGCATATGTGCGGGTGGTGAAGGGGAGGTAAATTAGAGCCATGGAAAGGGAACTAAGTTTTCACACTTCTGTTAA
TCCATTTCTTTTGAATTCCAGTCTATTATCCTCCCAGTCCACAACGCTGAACCGTGGCTGGACGAATGTTTGAGGTCTGTTTTGCAACAG
GACTTTGAAGGTACCATGGAGCTGTCTGTTTTCAATGATGCCAGTAAGGACAAGTCTGGGGCTATCATTGAAAAATGGAGAGTGAAGCTG
GAAGATTCTGGTGTCCACGTGATCATTGGGGGGCACGATTCTCCCTCTCCTAGAGGCGTCGGATACGCTAAAAATCAAGCAGTTGCCCAG
AGCTCAGGGTCTTACCTTTGCTTTTTGGATTCGGATGACGTCATGATGCCCCAGCGGGTGAGGCTGCAACACGAGGCTGCCGTTCAGCAC
CCGTCGAGCGGACGCTGCTTTCCTGAGCTGAATGGAGCAGGTTCAGACGGGCGGCCTGCGGACAGGCAGCGGTTTCCTCACATCCACTTT
GCATGTGATTCAAGAAATCATTGGTTGCAGAGTGAGGAGAGATCCCCCTAACTCCACCGAACGATACACACGTTGGATCAACCAGCTGAC
GCCGGAGCAGCTCCTAACCCAGGGCTGAAAAGACAGAAGTTTTGAGTGAAGACCTTCTTCAGGTGGAGAAGCGTCTGGAGCTGGTGAAAC
AGGTGTCCCACAGCACGCACAAGAAGCTCACCGCATGTCTGCAGGGCCAGCAAGGGGCAGAGGCTGACAAGCGCTCCAAAAAGTTGCCTT
TGACAACACTGGCTCAGTGTCTGATGGAGGGGTCAGCTATCCTGGGAGATGACACACTTCTTGGGAAGATGCTGAAACTCTGTGGAGAGA
CGGAGGACAAGCTGGCTCAGGAGCTGATACATTTTGAGTTGCAAGTAGAGAGAGACGTGATTGAGCCCCTGTTTTTGCTGGCGGAGGTGG
AAATCCCAAATATTCAAAAGCAGAGGAAACACTTAGCCAAGTTGGTGCTGGACATGGATTCCTCACGAACCAGGTGGCAGCAGACTTCCA
AGTCTTCAGGTTTGTCCAGCAGCTTACAGCCTGCGGGTGCCAAGGCTGATGCCCTCAGGGAAGAAATGGAAGAGGCTGCCAACAGAGTGG
AGATTTGCAGGGACCAGCTCTCAGCTGATATGTACAGTTTTGTGGCCAAAGAAATTGACTATGCAAACTACTTTCAAACGCTAATAGAAG
TGCAAGCTGAATACCACAGGAAGTCCCTGACACTATTGCAGGCTGTATTGCCTCAGATCAAAGCACAACAGGAGGCCTGGGTAGAGAAGC
CTTCCTTCGGGAAGCCGCTGGAGGAGCACCTCACCATCAGCGGCCGGGAGATCGCCTTCCCCATCGAGGCGTGTGTGACCATGCTGCTTG
AGTGTGGGATGCAGGAGGAGGGACTCTTCCGAGTAGCCCCCTCTGCCTCCAAACTGAAGAAGCTGAAAGCGGCCCTGGACTGCTGCGTGG
TGGATGTGCAGGAGTACTCGGCAGACCCCCACGCAATTGCAGGAGCTTTGAAATCTTACCTCCGAGAGTTGCCAGAACCTCTTATGACCT
TTGAACTCTATGATGAGTGGATCCAGGCTTCCAATGTCCAGGAGCAAGACAAGAAGCTTCAGGCTCTATGGAATGCTTGTGAAAAGTTGC
CCAAGGCCAATCACAACAACATCCGATACTTGATAAAATTTTTATCCAAGCTGTCAGAATATCAAGATGTAAACAAGATGACTCCCAGTA
ATATGGCAATTGTTTTAGGACCCAACCTCCTATGGCCACAAGCAGAAGGGAACATTACAGAGATGATGACCACAGTGTCGCTGCAAATTG
TTGGGATCATTGAACCTATCATCCAGCATGCAGACTGGTTCTTCCCTGGGGAGATAGAGTTCAACATTACTGGCAATTATGGGAGTCCAG
TACACGTGAACCATAATGCCAACTACAGCTCAATGCCCTCCCCAGACATGGACCCTGCTGACCGGCGCCAGCCCGAGCAGGCCCGCCGGC
CCCTCAGCGTCGCCACGGATAATATGATGCTGGAGTTTTACAAAAAGGATGGCCTTAGGAAAATCCAAAGCATGGGTGTGAGGGTCATGG
ACACAAACTGGGTGGCTCGAAGAGGCTCCTCGGCCGGTCGGAAAGTGTCCTGCGCCCCGCCCTCCATGCAGCCTCCCGCCCCGCCCGCCG
AGCTGGCTGCGCCCCTGCCTTCGCCGCTGCCGGAGCAGCCCCTGGACAGCCCCGCGGCCCCCGCGCTCTCTCCATCCGGCCTGGGCCTCC
AGCCTGGGCCCGAGCGCACCAGCACAACAAAAAGCAAGGAACTTTCTCCAGGCTCTGCACAGAAAGGAAGTCCAGGCTCCAGCCAGGGCA
CAGCCTGTGCAGGGACTCAACCAGGGGCTCAACCTGGAGCTCAGCCGGGCGCCAGCCCCAGCCCCAGCCAGCCGCCTGCAGACCAGAGTC
CTCACACCCTCCGGAAAGTTTCAAAGAAGCTGGCACCGATTCCACCCAAGGTCCCCTTTGGCCAGCCGGGGGCTATGGCAGACCAGTCCG
CTGGCCAGCCGTCCCCAGTCAGCCTGTCCCCCACCCCGCCCAGCACCCCGTCACCCTATGGACTGAGCTACCCTCAGGGGTACTCCTTGG
CCTCGGGCCAGCTCTCCCCAGCTGCAGCTCCTCCCCTGGCCTCTCCTTCTGTCTTTACAAGCACTTTGAGCAAATCGCGGCCCACTCCTA
AGCCGCGACAGAGACCTACTCTGCCGCCTCCTCAGCCTCCCACAGTAAACCTCTCGGCCTCTAGTCCACAGTCCACGGAGGCCCCCATGC
TAGATGGCATGTCCCCTGGGGAAAGCATGTCTACAGCTGTGTGACATGAGTGGCGCAGTTTTGGATACGTGTGAGGGGGATTTTCAGGAT
CTTGTCCACTTTGATATTCCCTCGATCCACATAGAGCTCGGGTCGACGCTCCGCCTGAGTCCCCTGGAGCACATGCGGCGACACTCAGTA
ACTGACAAGAGGGACTCGGAGGAGGAGTCTGAGAGCACCGCCCTCTGACATGACACCGCCCATCCTGCCTCGCGTGTACATACATCACGG
GCCCTAGGAACGCCGCCAGGAGCAGCGTCCATGAGCTTGCCAAGTGTTCTCTGCTGGCTCTTTCCTGCCACTGCCAACACGAGGTTGGAA
TTTGGCAGAAAATTGTGATCTCCAGTCCGTGTGGTGATGCTGGTGGTGCAGGTTTTGTTTGTTCCTTTCGGGTGGTGACTTCGGCCTTTT
GTTTGACCTTTGCCTTTTGACTTTGTGCCTCTTTTGATCCACTTTCAGCCTCCATGCCAGAAAACACCCACCTCTCCATCCAAGGCTGGT
CAGGAACGTCCTTTGCAGGGTCGGGGTGGTGCGGGAGAGGCTCACTTTGCCTGGTTAGACCCAAGGGCTGCTACCTTTTCCTTGGACGGC

>8713_8713_1_B3GNTL1-ARHGAP44_B3GNTL1_chr17_80962991_ENST00000576599_ARHGAP44_chr17_12798257_ENST00000262444_length(amino acids)=750AA_BP=
MSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFEL
QVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSF
VAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAP
SASKLKKLKAALDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLIKF
LSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNITGNYGSPVHVNHNANYSSMPS
PDMDPADRRQPEQARRPLSVATDNMMLEFYKKDGLRKIQSMGVRVMDTNWVARRGSSAGRKVSCAPPSMQPPAPPAELAAPLPSPLPEQP
LDSPAAPALSPSGLGLQPGPERTSTTKSKELSPGSAQKGSPGSSQGTACAGTQPGAQPGAQPGASPSPSQPPADQSPHTLRKVSKKLAPI
PPKVPFGQPGAMADQSAGQPSPVSLSPTPPSTPSPYGLSYPQGYSLASGQLSPAAAPPLASPSVFTSTLSKSRPTPKPRQRPTLPPPQPP

--------------------------------------------------------------
>8713_8713_2_B3GNTL1-ARHGAP44_B3GNTL1_chr17_80962991_ENST00000576599_ARHGAP44_chr17_12798257_ENST00000340825_length(transcript)=4780nt_BP=922nt
ATTCTCCCGCCTCAGCTTCCCGAGTAGCTGGGACTACAGGAGCCTGCCACCACGCCTGGCTAATTTTTTGTATTTTTAGTAGAGATGGGG
TTTCACCATGTTAGCCAGGATGGTCTCAATCTCCTGACCTTGTAATCCACCCACCTCGGCCTCCCAAAGTCCTTTCAGTTTTTTTTTCAC
TTTCAAAAACATGTAGAAGGCAGTTCAGGGAAAGCTAAGACGTAAAGAATCTTACAAGCATGTTAAGAGCCTGGAGAAAAGGAGTGGACA
CCTTTTGTTTGTCACGGCATATGTGCGGGTGGTGAAGGGGAGGTAAATTAGAGCCATGGAAAGGGAACTAAGTTTTCACACTTCTGTTAA
TCCATTTCTTTTGAATTCCAGTCTATTATCCTCCCAGTCCACAACGCTGAACCGTGGCTGGACGAATGTTTGAGGTCTGTTTTGCAACAG
GACTTTGAAGGTACCATGGAGCTGTCTGTTTTCAATGATGCCAGTAAGGACAAGTCTGGGGCTATCATTGAAAAATGGAGAGTGAAGCTG
GAAGATTCTGGTGTCCACGTGATCATTGGGGGGCACGATTCTCCCTCTCCTAGAGGCGTCGGATACGCTAAAAATCAAGCAGTTGCCCAG
AGCTCAGGGTCTTACCTTTGCTTTTTGGATTCGGATGACGTCATGATGCCCCAGCGGGTGAGGCTGCAACACGAGGCTGCCGTTCAGCAC
CCGTCGAGCGGACGCTGCTTTCCTGAGCTGAATGGAGCAGGTTCAGACGGGCGGCCTGCGGACAGGCAGCGGTTTCCTCACATCCACTTT
GCATGTGATTCAAGAAATCATTGGTTGCAGAGTGAGGAGAGATCCCCCTAACTCCACCGAACGATACACACGTTGGATCAACCAGCTGAC
GCCGGAGCAGCTCCTAACCCAGGGCTGAAAAGACAGAAGTTTTGAGTGAAGACCTTCTTCAGGTGGAGAAGCGTCTGGAGCTGGTGAAAC
AGGTGTCCCACAGCACGCACAAGAAGCTCACCGCATGTCTGCAGGGCCAGCAAGGGGCAGAGGCTGACAAGCGCTCCAAAAAGTTGCCTT
TGACAACACTGGCTCAGTGTCTGATGGAGGGGTCAGCTATCCTGGGAGATGACACACTTCTTGGGAAGATGCTGAAACTCTGTGGAGAGA
CGGAGGACAAGCTGGCTCAGGAGCTGATACATTTTGAGTTGCAAGTAGAGAGAGACGTGATTGAGCCCCTGTTTTTGCTGGCGGAGGTGG
AAATCCCAAATATTCAAAAGCAGAGGAAACACTTAGCCAAGTTGGTGCTGGACATGGATTCCTCACGAACCAGGTGGCAGCAGACTTCCA
AGTCTTCAGGTTTGTCCAGCAGCTTACAGCCTGCGGGTGCCAAGGCTGATGCCCTCAGGGAAGAAATGGAAGAGGCTGCCAACAGAGTGG
AGATTTGCAGGGACCAGCTCTCAGCTGATATGTACAGTTTTGTGGCCAAAGAAATTGACTATGCAAACTACTTTCAAACGCTAATAGAAG
TGCAAGCTGAATACCACAGGAAGTCCCTGACACTATTGCAGGCTGTATTGCCTCAGATCAAAGCACAACAGGAGGCCTGGGTAGAGAAGC
CTTCCTTCGGGAAGCCGCTGGAGGAGCACCTCACCATCAGCGGCCGGGAGATCGCCTTCCCCATCGAGGCGTGTGTGACCATGCTGCTTG
AGTGTGGGATGCAGGAGGAGGGACTCTTCCGAGTAGCCCCCTCTGCCTCCAAACTGAAGAAGCTGAAAGCGGCCCTGGACTGCTGCGTGG
TGGATGTGCAGGAGTACTCGGCAGACCCCCACGCAATTGCAGGAGCTTTGAAATCTTACCTCCGAGAGTTGCCAGAACCTCTTATGACCT
TTGAACTCTATGATGAGTGGATCCAGGCTTCCAATGTCCAGGAGCAAGACAAGAAGCTTCAGGCTCTATGGAATGCTTGTGAAAAGTTGC
CCAAGGCCAATCACAACAACATCCGATACTTGATAAAATTTTTATCCAAGCTGTCAGAATATCAAGATGTAAACAAGATGACTCCCAGTA
ATATGGCAATTGTTTTAGGACCCAACCTCCTATGGCCACAAGCAGAAGGGAACATTACAGAGATGATGACCACAGTGTCGCTGCAAATTG
TTGGGATCATTGAACCTATCATCCAGCATGCAGACTGGTTCTTCCCTGGGGAGATAGAGTTCAACATTACTGGCAATTATGGGAGTCCAG
TACACGTGAACCATAATGCCAACTACAGCTCAATGCCCTCCCCAGACATGGACCCTGCTGACCGGCGCCAGCCCGAGCAGGCCCGCCGGC
CCCTCAGCGTCGCCACGGATAATATGATGCTGGAGTTTTACAAAAAGGATGGCATGGGTGTGAGGGTCATGGACACAAACTGGGTGGCTC
GAAGAGGCTCCTCGGCCGGTCGGAAAGTGTCCTGCGCCCCGCCCTCCATGCAGCCTCCCGCCCCGCCCGCCGAGCTGGCTGCGCCCCTGC
CTTCGCCGCTGCCGGAGCAGCCCCTGGACAGCCCCGCGGCCCCCGCGCTCTCTCCATCCGGCCTGGGCCTCCAGCCTGGGCCCGAGCGCA
CCAGCACAACAAAAAGCAAGGAACTTTCTCCAGGCTCTGCACAGAAAGGAAGTCCAGGCTCCAGCCAGGGCACAGCCTGTGCAGGGACTC
AACCAGGGGCTCAACCTGGAGCTCAGCCGGGCGCCAGCCCCAGCCCCAGCCAGCCGCCTGCAGACCAGAGTCCTCACACCCTCCGGAAAG
TTTCAAAGAAGCTGGCACCGATTCCACCCAAGGTCCCCTTTGGCCAGCCGGGGGCTATGGCAGACCAGTCCGCTGGCCAGCCGTCCCCAG
TCAGCCTGTCCCCCACCCCGCCCAGCACCCCGTCACCCTATGGACTGAGCTACCCTCAGGGGTACTCCTTGGCCTCGGGCCAGCTCTCCC
CAGCTGCAGCTCCTCCCCTGGCCTCTCCTTCTGTCTTTACAAGCACTTTGAGCAAATCGCGGCCCACTCCTAAGCCGCGACAGAGACCTA
CTCTGCCGCCTCCTCAGCCTCCCACAGTAAACCTCTCGGCCTCTAGTCCACAGTCCACGGAGGCCCCCATGCTAGATGGCATGTCCCCTG
GGGAAAGCATGTCTACAGATCTTGTCCACTTTGATATTCCCTCGATCCACATAGAGCTCGGGTCGACGCTCCGCCTGAGTCCCCTGGAGC
ACATGCGGCGACACTCAGTAACTGACAAGAGGGACTCGGAGGAGGAGTCTGAGAGCACCGCCCTCTGACATGACACCGCCCATCCTGCCT
CGCGTGTACATACATCACGGGCCCTAGGAACGCCGCCAGGAGCAGCGTCCATGAGCTTGCCAAGTGTTCTCTGCTGGCTCTTTCCTGCCA
CTGCCAACACGAGGTTGGAATTTGGCAGAAAATTGTGATCTCCAGTCCGTGTGGTGATGCTGGTGGTGCAGGTTTTGTTTGTTCCTTTCG
GGTGGTGACTTCGGCCTTTTGTTTGACCTTTGCCTTTTGACTTTGTGCCTCTTTTGATCCACTTTCAGCCTCCATGCCAGAAAACACCCA
CCTCTCCATCCAAGGCTGGTCAGGAACGTCCTTTGCAGGGTCGGGGTGGTGCGGGAGAGGCTCACTTTGCCTGGTTAGACCCAAGGGCTG
CTACCTTTTCCTTGGACGGCTCATGTCAGGTCTTGCAGGATCAGTTTAATGGCCACAGAAAGGAAGCAGGACAGCAGGGCCCCTCTCACC
CACAACTGGACCAGGTCCAGGATTCTAGCAGTCCTGGGGCACTGACCTTTGCCAGCTACCTGGGGGAGGGCTTGCCACTGGAAAACCTTT
CAGGCCGCCCCCATCAGTGGGCTCCAAAGTAAATGGCTGAAAACAAAAATGTTTCACTTCCTAACAGTTTTCCTTTTTCCACTGTGTGAC
TGAAAGCTCCTATATCATTTTATATTTCTGAATCTATAAAACAAAACAAACAAGCCTGACAGTGTCTGGAGGAGCCAAAGGTGGCCTCCC
TGTCCCCAAATATATTGGCTATATGAGAGTAATTTTACCCCTCTACGTACCTAAAGGCACCCAGTTCACTAGTCTGTGGGGTCCTGGAGC
CTGTCTCTTCTTTCTGGAGGTTCAAACTGAATAGCAATAATTACGTTACCCAAAGCATGTGGAGGAAAAGTGAAACCAGCCACGGAGACG
CTGGCCCACGGGCTCGGCCTGCGGTGTGGCCTGCTTTGCTCACCAGCGTCAGCCGCTCATTTCCTTCTCATGAAGTCCCATCTGGTCATG
GGGACGAGGGCCGGGAGGGCACCGGGTAGCCTTTTCACACTTGGGGATTAGGGGAGTGAGAAAAGATTTGGGCCATGCATGCAAAGTCAA
AGTTTAAAATTTTATCCTTTTCAAATAGATGATATAATATACCTATACATGATATAATATTTGTATATATGAAATCTCTCTATATTTGTT
TAATTTGAGCCATTCAATCTAAACCAATGTACAGGTGTACAATGAAAAATTTAAATGCTTAGTTATTTTTCCCAACACAGTGTAAAGTCA
CCCTCCTCTGAGAGTGGGATGTGCAGAGTTTTGATGTTGCAGCTTTGCTCACTTCCTGGCAAGGGCAGGTCATGCCTCAATTTGTAATGG
GAGTCTGGGGTAAGGGTGGGGGTTGAAAGTTGTTATCTTTAAATACATGTACAAATCGTTGTCAAAAGTAACGTTATTAAAATAGATTTA

>8713_8713_2_B3GNTL1-ARHGAP44_B3GNTL1_chr17_80962991_ENST00000576599_ARHGAP44_chr17_12798257_ENST00000340825_length(amino acids)=788AA_BP=
MSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFEL
QVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSF
VAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAP
SASKLKKLKAALDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLIKF
LSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNITGNYGSPVHVNHNANYSSMPS
PDMDPADRRQPEQARRPLSVATDNMMLEFYKKDGMGVRVMDTNWVARRGSSAGRKVSCAPPSMQPPAPPAELAAPLPSPLPEQPLDSPAA
PALSPSGLGLQPGPERTSTTKSKELSPGSAQKGSPGSSQGTACAGTQPGAQPGAQPGASPSPSQPPADQSPHTLRKVSKKLAPIPPKVPF
GQPGAMADQSAGQPSPVSLSPTPPSTPSPYGLSYPQGYSLASGQLSPAAAPPLASPSVFTSTLSKSRPTPKPRQRPTLPPPQPPTVNLSA

--------------------------------------------------------------
>8713_8713_3_B3GNTL1-ARHGAP44_B3GNTL1_chr17_80962991_ENST00000576599_ARHGAP44_chr17_12798257_ENST00000379672_length(transcript)=4797nt_BP=922nt
ATTCTCCCGCCTCAGCTTCCCGAGTAGCTGGGACTACAGGAGCCTGCCACCACGCCTGGCTAATTTTTTGTATTTTTAGTAGAGATGGGG
TTTCACCATGTTAGCCAGGATGGTCTCAATCTCCTGACCTTGTAATCCACCCACCTCGGCCTCCCAAAGTCCTTTCAGTTTTTTTTTCAC
TTTCAAAAACATGTAGAAGGCAGTTCAGGGAAAGCTAAGACGTAAAGAATCTTACAAGCATGTTAAGAGCCTGGAGAAAAGGAGTGGACA
CCTTTTGTTTGTCACGGCATATGTGCGGGTGGTGAAGGGGAGGTAAATTAGAGCCATGGAAAGGGAACTAAGTTTTCACACTTCTGTTAA
TCCATTTCTTTTGAATTCCAGTCTATTATCCTCCCAGTCCACAACGCTGAACCGTGGCTGGACGAATGTTTGAGGTCTGTTTTGCAACAG
GACTTTGAAGGTACCATGGAGCTGTCTGTTTTCAATGATGCCAGTAAGGACAAGTCTGGGGCTATCATTGAAAAATGGAGAGTGAAGCTG
GAAGATTCTGGTGTCCACGTGATCATTGGGGGGCACGATTCTCCCTCTCCTAGAGGCGTCGGATACGCTAAAAATCAAGCAGTTGCCCAG
AGCTCAGGGTCTTACCTTTGCTTTTTGGATTCGGATGACGTCATGATGCCCCAGCGGGTGAGGCTGCAACACGAGGCTGCCGTTCAGCAC
CCGTCGAGCGGACGCTGCTTTCCTGAGCTGAATGGAGCAGGTTCAGACGGGCGGCCTGCGGACAGGCAGCGGTTTCCTCACATCCACTTT
GCATGTGATTCAAGAAATCATTGGTTGCAGAGTGAGGAGAGATCCCCCTAACTCCACCGAACGATACACACGTTGGATCAACCAGCTGAC
GCCGGAGCAGCTCCTAACCCAGGGCTGAAAAGACAGAAGTTTTGAGTGAAGACCTTCTTCAGGTGGAGAAGCGTCTGGAGCTGGTGAAAC
AGGTGTCCCACAGCACGCACAAGAAGCTCACCGCATGTCTGCAGGGCCAGCAAGGGGCAGAGGCTGACAAGCGCTCCAAAAAGTTGCCTT
TGACAACACTGGCTCAGTGTCTGATGGAGGGGTCAGCTATCCTGGGAGATGACACACTTCTTGGGAAGATGCTGAAACTCTGTGGAGAGA
CGGAGGACAAGCTGGCTCAGGAGCTGATACATTTTGAGTTGCAAGTAGAGAGAGACGTGATTGAGCCCCTGTTTTTGCTGGCGGAGGTGG
AAATCCCAAATATTCAAAAGCAGAGGAAACACTTAGCCAAGTTGGTGCTGGACATGGATTCCTCACGAACCAGGTGGCAGCAGACTTCCA
AGTCTTCAGGTTTGTCCAGCAGCTTACAGCCTGCGGGTGCCAAGGCTGATGCCCTCAGGGAAGAAATGGAAGAGGCTGCCAACAGAGTGG
AGATTTGCAGGGACCAGCTCTCAGCTGATATGTACAGTTTTGTGGCCAAAGAAATTGACTATGCAAACTACTTTCAAACGCTAATAGAAG
TGCAAGCTGAATACCACAGGAAGTCCCTGACACTATTGCAGGCTGTATTGCCTCAGATCAAAGCACAACAGGAGGCCTGGGTAGAGAAGC
CTTCCTTCGGGAAGCCGCTGGAGGAGCACCTCACCATCAGCGGCCGGGAGATCGCCTTCCCCATCGAGGCGTGTGTGACCATGCTGCTTG
AGTGTGGGATGCAGGAGGAGGGACTCTTCCGAGTAGCCCCCTCTGCCTCCAAACTGAAGAAGCTGAAAGCGGCCCTGGACTGCTGCGTGG
TGGATGTGCAGGAGTACTCGGCAGACCCCCACGCAATTGCAGGAGCTTTGAAATCTTACCTCCGAGAGTTGCCAGAACCTCTTATGACCT
TTGAACTCTATGATGAGTGGATCCAGGCTTCCAATGTCCAGGAGCAAGACAAGAAGCTTCAGGCTCTATGGAATGCTTGTGAAAAGTTGC
CCAAGGCCAATCACAACAACATCCGATACTTGATAAAATTTTTATCCAAGCTGTCAGAATATCAAGATGTAAACAAGATGACTCCCAGTA
ATATGGCAATTGTTTTAGGACCCAACCTCCTATGGCCACAAGCAGAAGGGAACATTACAGAGATGATGACCACAGTGTCGCTGCAAATTG
TTGGGATCATTGAACCTATCATCCAGCATGCAGACTGGTTCTTCCCTGGGGAGATAGAGTTCAACATTACTGGCAATTATGGGAGTCCAG
TACACGTGAACCATAATGCCAACTACAGCTCAATGCCCTCCCCAGACATGGACCCTGCTGACCGGCGCCAGCCCGAGCAGGCCCGCCGGC
CCCTCAGCGTCGCCACGGATAATATGATGCTGGAGTTTTACAAAAAGGATGGCCTTAGGAAAATCCAAAGCATGGGTGTGAGGGTCATGG
ACACAAACTGGGTGGCTCGAAGAGGCTCCTCGGCCGGTCGGAAAGTGTCCTGCGCCCCGCCCTCCATGCAGCCTCCCGCCCCGCCCGCCG
AGCTGGCTGCGCCCCTGCCTTCGCCGCTGCCGGAGCAGCCCCTGGACAGCCCCGCGGCCCCCGCGCTCTCTCCATCCGGCCTGGGCCTCC
AGCCTGGGCCCGAGCGCACCAGCACAACAAAAAGCAAGGAACTTTCTCCAGGCTCTGCACAGAAAGGAAGTCCAGGCTCCAGCCAGGGCA
CAGCCTGTGCAGGGACTCAACCAGGGGCTCAACCTGGAGCTCAGCCGGGCGCCAGCCCCAGCCCCAGCCAGCCGCCTGCAGACCAGAGTC
CTCACACCCTCCGGAAAGTTTCAAAGAAGCTGGCACCGATTCCACCCAAGGTCCCCTTTGGCCAGCCGGGGGCTATGGCAGACCAGTCCG
CTGGCCAGCCGTCCCCAGTCAGCCTGTCCCCCACCCCGCCCAGCACCCCGTCACCCTATGGACTGAGCTACCCTCAGGGGTACTCCTTGG
CCTCGGGCCAGCTCTCCCCAGCTGCAGCTCCTCCCCTGGCCTCTCCTTCTGTCTTTACAAGCACTTTGAGCAAATCGCGGCCCACTCCTA
AGCCGCGACAGAGACCTACTCTGCCGCCTCCTCAGCCTCCCACAGTAAACCTCTCGGCCTCTAGTCCACAGTCCACGGAGGCCCCCATGC
TAGATGGCATGTCCCCTGGGGAAAGCATGTCTACAGATCTTGTCCACTTTGATATTCCCTCGATCCACATAGAGCTCGGGTCGACGCTCC
GCCTGAGTCCCCTGGAGCACATGCGGCGACACTCAGTAACTGACAAGAGGGACTCGGAGGAGGAGTCTGAGAGCACCGCCCTCTGACATG
ACACCGCCCATCCTGCCTCGCGTGTACATACATCACGGGCCCTAGGAACGCCGCCAGGAGCAGCGTCCATGAGCTTGCCAAGTGTTCTCT
GCTGGCTCTTTCCTGCCACTGCCAACACGAGGTTGGAATTTGGCAGAAAATTGTGATCTCCAGTCCGTGTGGTGATGCTGGTGGTGCAGG
TTTTGTTTGTTCCTTTCGGGTGGTGACTTCGGCCTTTTGTTTGACCTTTGCCTTTTGACTTTGTGCCTCTTTTGATCCACTTTCAGCCTC
CATGCCAGAAAACACCCACCTCTCCATCCAAGGCTGGTCAGGAACGTCCTTTGCAGGGTCGGGGTGGTGCGGGAGAGGCTCACTTTGCCT
GGTTAGACCCAAGGGCTGCTACCTTTTCCTTGGACGGCTCATGTCAGGTCTTGCAGGATCAGTTTAATGGCCACAGAAAGGAAGCAGGAC
AGCAGGGCCCCTCTCACCCACAACTGGACCAGGTCCAGGATTCTAGCAGTCCTGGGGCACTGACCTTTGCCAGCTACCTGGGGGAGGGCT
TGCCACTGGAAAACCTTTCAGGCCGCCCCCATCAGTGGGCTCCAAAGTAAATGGCTGAAAACAAAAATGTTTCACTTCCTAACAGTTTTC
CTTTTTCCACTGTGTGACTGAAAGCTCCTATATCATTTTATATTTCTGAATCTATAAAACAAAACAAACAAGCCTGACAGTGTCTGGAGG
AGCCAAAGGTGGCCTCCCTGTCCCCAAATATATTGGCTATATGAGAGTAATTTTACCCCTCTACGTACCTAAAGGCACCCAGTTCACTAG
TCTGTGGGGTCCTGGAGCCTGTCTCTTCTTTCTGGAGGTTCAAACTGAATAGCAATAATTACGTTACCCAAAGCATGTGGAGGAAAAGTG
AAACCAGCCACGGAGACGCTGGCCCACGGGCTCGGCCTGCGGTGTGGCCTGCTTTGCTCACCAGCGTCAGCCGCTCATTTCCTTCTCATG
AAGTCCCATCTGGTCATGGGGACGAGGGCCGGGAGGGCACCGGGTAGCCTTTTCACACTTGGGGATTAGGGGAGTGAGAAAAGATTTGGG
CCATGCATGCAAAGTCAAAGTTTAAAATTTTATCCTTTTCAAATAGATGATATAATATACCTATACATGATATAATATTTGTATATATGA
AATCTCTCTATATTTGTTTAATTTGAGCCATTCAATCTAAACCAATGTACAGGTGTACAATGAAAAATTTAAATGCTTAGTTATTTTTCC
CAACACAGTGTAAAGTCACCCTCCTCTGAGAGTGGGATGTGCAGAGTTTTGATGTTGCAGCTTTGCTCACTTCCTGGCAAGGGCAGGTCA
TGCCTCAATTTGTAATGGGAGTCTGGGGTAAGGGTGGGGGTTGAAAGTTGTTATCTTTAAATACATGTACAAATCGTTGTCAAAAGTAAC

>8713_8713_3_B3GNTL1-ARHGAP44_B3GNTL1_chr17_80962991_ENST00000576599_ARHGAP44_chr17_12798257_ENST00000379672_length(amino acids)=794AA_BP=
MSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFEL
QVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSF
VAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAP
SASKLKKLKAALDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLIKF
LSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNITGNYGSPVHVNHNANYSSMPS
PDMDPADRRQPEQARRPLSVATDNMMLEFYKKDGLRKIQSMGVRVMDTNWVARRGSSAGRKVSCAPPSMQPPAPPAELAAPLPSPLPEQP
LDSPAAPALSPSGLGLQPGPERTSTTKSKELSPGSAQKGSPGSSQGTACAGTQPGAQPGAQPGASPSPSQPPADQSPHTLRKVSKKLAPI
PPKVPFGQPGAMADQSAGQPSPVSLSPTPPSTPSPYGLSYPQGYSLASGQLSPAAAPPLASPSVFTSTLSKSRPTPKPRQRPTLPPPQPP

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for B3GNTL1-ARHGAP44


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneARHGAP44chr17:80962991chr17:12798257ENST00000379672021731_81817.666666666666668819.0BST2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for B3GNTL1-ARHGAP44


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for B3GNTL1-ARHGAP44


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource