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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:STARD3-CACNA1C (FusionGDB2 ID:87172)

Fusion Gene Summary for STARD3-CACNA1C

check button Fusion gene summary
Fusion gene informationFusion gene name: STARD3-CACNA1C
Fusion gene ID: 87172
HgeneTgene
Gene symbol

STARD3

CACNA1C

Gene ID

10948

775

Gene nameStAR related lipid transfer domain containing 3calcium voltage-gated channel subunit alpha1 C
SynonymsCAB1|MLN64|es64CACH2|CACN2|CACNL1A1|CCHL1A1|CaV1.2|LQT8|TS|TS. LQT8
Cytomap

17q12

12p13.33

Type of geneprotein-codingprotein-coding
DescriptionstAR-related lipid transfer protein 3MLN 64START domain-containing protein 3StAR-related lipid transfer (START) domain containing 3metastatic lymph node gene 64 proteinmetastatic lymph node protein 64steroidogenic acute regulatory protein relatedvoltage-dependent L-type calcium channel subunit alpha-1CDHPR, alpha-1 subunitcalcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac musclecalcium channel, cardic dihydropyridine-sensitive, alpha-1 subunitcalcium channel, voltage-dependent,
Modification date2020031320200315
UniProtAcc

STARD3NL

Q13936

Ensembl transtripts involved in fusion geneENST00000578232, ENST00000336308, 
ENST00000394250, ENST00000544210, 
ENST00000580611, 		ENST00000327702, 
ENST00000335762, ENST00000344100, 
ENST00000347598, ENST00000399591, 
ENST00000399595, ENST00000399597, 
ENST00000399601, ENST00000399603, 
ENST00000399606, ENST00000399617, 
ENST00000399621, ENST00000399629, 
ENST00000399634, ENST00000399637, 
ENST00000399638, ENST00000399641, 
ENST00000399644, ENST00000399649, 
ENST00000399655, ENST00000402845, 
ENST00000406454, ENST00000480911, 
ENST00000491104, 
Fusion gene scores* DoF score25 X 11 X 9=247521 X 20 X 10=4200
# samples 3524
** MAII scorelog2(35/2475*10)=-2.82200169802201
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(24/4200*10)=-4.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STARD3 [Title/Abstract] AND CACNA1C [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSTARD3(37793484)-CACNA1C(2558142), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTARD3

GO:0030301

cholesterol transport

28377464

HgeneSTARD3

GO:0099044

vesicle tethering to endoplasmic reticulum

24105263|28377464

TgeneCACNA1C

GO:0007204

positive regulation of cytosolic calcium ion concentration

12130699

TgeneCACNA1C

GO:0061577

calcium ion transmembrane transport via high voltage-gated calcium channel

15454078

TgeneCACNA1C

GO:0070588

calcium ion transmembrane transport

15454078


check buttonFusion gene breakpoints across STARD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CACNA1C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-OL-A5RZ-01ASTARD3chr17

37793484

+CACNA1Cchr12

2558142

+


Top

Fusion Gene ORF analysis for STARD3-CACNA1C

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000578232ENST00000327702STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
3UTR-3CDSENST00000578232ENST00000335762STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
3UTR-3CDSENST00000578232ENST00000344100STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
3UTR-3CDSENST00000578232ENST00000347598STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
3UTR-3CDSENST00000578232ENST00000399591STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
3UTR-3CDSENST00000578232ENST00000399595STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
3UTR-3CDSENST00000578232ENST00000399597STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
3UTR-3CDSENST00000578232ENST00000399601STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
3UTR-3CDSENST00000578232ENST00000399603STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
3UTR-3CDSENST00000578232ENST00000399606STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
3UTR-3CDSENST00000578232ENST00000399617STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
3UTR-3CDSENST00000578232ENST00000399621STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
3UTR-3CDSENST00000578232ENST00000399629STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
3UTR-3CDSENST00000578232ENST00000399634STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
3UTR-3CDSENST00000578232ENST00000399637STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
3UTR-3CDSENST00000578232ENST00000399638STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
3UTR-3CDSENST00000578232ENST00000399641STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
3UTR-3CDSENST00000578232ENST00000399644STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
3UTR-3CDSENST00000578232ENST00000399649STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
3UTR-3CDSENST00000578232ENST00000399655STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
3UTR-3CDSENST00000578232ENST00000402845STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
3UTR-3CDSENST00000578232ENST00000406454STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
3UTR-3CDSENST00000578232ENST00000480911STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
3UTR-intronENST00000578232ENST00000491104STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000336308ENST00000327702STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000336308ENST00000335762STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000336308ENST00000344100STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000336308ENST00000347598STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000336308ENST00000399591STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000336308ENST00000399595STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000336308ENST00000399597STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000336308ENST00000399601STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000336308ENST00000399603STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000336308ENST00000399606STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000336308ENST00000399617STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000336308ENST00000399621STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000336308ENST00000399629STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000336308ENST00000399634STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000336308ENST00000399637STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000336308ENST00000399638STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000336308ENST00000399641STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000336308ENST00000399644STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000336308ENST00000399649STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000336308ENST00000399655STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000336308ENST00000402845STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000336308ENST00000406454STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000336308ENST00000480911STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000394250ENST00000327702STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000394250ENST00000335762STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000394250ENST00000344100STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000394250ENST00000347598STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000394250ENST00000399591STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000394250ENST00000399595STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000394250ENST00000399597STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000394250ENST00000399601STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000394250ENST00000399603STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000394250ENST00000399606STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000394250ENST00000399617STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000394250ENST00000399621STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000394250ENST00000399629STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000394250ENST00000399634STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000394250ENST00000399637STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000394250ENST00000399638STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000394250ENST00000399641STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000394250ENST00000399644STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000394250ENST00000399649STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000394250ENST00000399655STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000394250ENST00000402845STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000394250ENST00000406454STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000394250ENST00000480911STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000544210ENST00000327702STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000544210ENST00000335762STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000544210ENST00000344100STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000544210ENST00000347598STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000544210ENST00000399591STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000544210ENST00000399595STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000544210ENST00000399597STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000544210ENST00000399601STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000544210ENST00000399603STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000544210ENST00000399606STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000544210ENST00000399617STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000544210ENST00000399621STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000544210ENST00000399629STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000544210ENST00000399634STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000544210ENST00000399637STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000544210ENST00000399638STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000544210ENST00000399641STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000544210ENST00000399644STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000544210ENST00000399649STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000544210ENST00000399655STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000544210ENST00000402845STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000544210ENST00000406454STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000544210ENST00000480911STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000580611ENST00000327702STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000580611ENST00000335762STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000580611ENST00000344100STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000580611ENST00000347598STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000580611ENST00000399591STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000580611ENST00000399595STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000580611ENST00000399597STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000580611ENST00000399601STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000580611ENST00000399603STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000580611ENST00000399606STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000580611ENST00000399617STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000580611ENST00000399621STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000580611ENST00000399629STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000580611ENST00000399634STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000580611ENST00000399637STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000580611ENST00000399638STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000580611ENST00000399641STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000580611ENST00000399644STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000580611ENST00000399649STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000580611ENST00000399655STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000580611ENST00000402845STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000580611ENST00000406454STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-3CDSENST00000580611ENST00000480911STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-intronENST00000336308ENST00000491104STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-intronENST00000394250ENST00000491104STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-intronENST00000544210ENST00000491104STARD3chr17

37793484

+CACNA1Cchr12

2558142

+
5UTR-intronENST00000580611ENST00000491104STARD3chr17

37793484

+CACNA1Cchr12

2558142

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for STARD3-CACNA1C


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
STARD3chr1737793484+CACNA1Cchr122558141+1.98E-050.9999802
STARD3chr1737793484+CACNA1Cchr122558141+1.98E-050.9999802

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for STARD3-CACNA1C


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:37793484/:2558142)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
STARD3

STARD3NL

CACNA1C

Q13936

234FUNCTION: Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents (PubMed:8392192, PubMed:7737988, PubMed:9087614, PubMed:9013606, PubMed:9607315, PubMed:12176756, PubMed:17071743, PubMed:11741969, PubMed:8099908, PubMed:12181424, PubMed:29078335, PubMed:29742403, PubMed:16299511, PubMed:20953164, PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506, PubMed:27218670, PubMed:23677916). Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm (PubMed:15454078, PubMed:15863612, PubMed:17224476, PubMed:24728418, PubMed:26253506). Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells (PubMed:28119464). Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable). {ECO:0000250|UniProtKB:P15381, ECO:0000269|PubMed:11741969, ECO:0000269|PubMed:12176756, ECO:0000269|PubMed:12181424, ECO:0000269|PubMed:15454078, ECO:0000269|PubMed:15863612, ECO:0000269|PubMed:16299511, ECO:0000269|PubMed:17071743, ECO:0000269|PubMed:17224476, ECO:0000269|PubMed:20953164, ECO:0000269|PubMed:23677916, ECO:0000269|PubMed:24728418, ECO:0000269|PubMed:26253506, ECO:0000269|PubMed:27218670, ECO:0000269|PubMed:28119464, ECO:0000269|PubMed:29078335, ECO:0000269|PubMed:29742403, ECO:0000269|PubMed:7737988, ECO:0000269|PubMed:8099908, ECO:0000269|PubMed:8392192, ECO:0000269|PubMed:9013606, ECO:0000269|PubMed:9087614, ECO:0000269|PubMed:9607315, ECO:0000305}.; FUNCTION: (Microbial infection) Acts as a receptor for Influenzavirus (PubMed:29779930). May play a critical role in allowing virus entry when sialylated and expressed on lung tissues (PubMed:29779930). {ECO:0000269|PubMed:29779930}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

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* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for STARD3-CACNA1C


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for STARD3-CACNA1C


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for STARD3-CACNA1C


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for STARD3-CACNA1C


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource