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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:STK10-PCBD2 (FusionGDB2 ID:87436)

Fusion Gene Summary for STK10-PCBD2

Fusion gene summary

Fusion gene information	Fusion gene name: STK10-PCBD2
	Fusion gene ID: 87436
		Hgene	Tgene
	Gene symbol	STK10	PCBD2
	Gene ID	6793	84105
	Gene name	serine/threonine kinase 10	pterin-4 alpha-carbinolamine dehydratase 2
	Synonyms	LOK\|PRO2729	DCOH2\|DCOHM\|PHS2
	Cytomap	5q35.1	5q31.1
	Type of gene	protein-coding	protein-coding
	Description	serine/threonine-protein kinase 10lymphocyte-oriented kinase	pterin-4-alpha-carbinolamine dehydratase 24-alpha-hydroxy-tetrahydropterin dehydratase 26-pyruvoyl-tetrahydropterin synthase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2DcoH-like protein DCoHmHNF-1-alpha dimerization cofactorPH
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000176763, ENST00000517775,	ENST00000510013, ENST00000254908, ENST00000512783,
Fusion gene scores	* DoF score	9 X 11 X 6=594	12 X 26 X 5=1560
	# samples	13	22
	** MAII score	log2(13/594*10)=-2.19195130777231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(22/1560*10)=-2.82597060022495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: STK10 [Title/Abstract] AND PCBD2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	STK10(171583627)-PCBD2(134294729), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	STK10	GO:0046777	protein autophosphorylation	12639966\|18239682
Tgene	PCBD2	GO:0045893	positive regulation of transcription, DNA-templated	11980910

Fusion gene breakpoints across STK10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PCBD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-13-0760	STK10	chr5	171583627	-	PCBD2	chr5	134294729	+

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Fusion Gene ORF analysis for STK10-PCBD2

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000176763	ENST00000510013	STK10	chr5	171583627	-	PCBD2	chr5	134294729	+
In-frame	ENST00000176763	ENST00000254908	STK10	chr5	171583627	-	PCBD2	chr5	134294729	+
In-frame	ENST00000176763	ENST00000512783	STK10	chr5	171583627	-	PCBD2	chr5	134294729	+
intron-3CDS	ENST00000517775	ENST00000254908	STK10	chr5	171583627	-	PCBD2	chr5	134294729	+
intron-3CDS	ENST00000517775	ENST00000512783	STK10	chr5	171583627	-	PCBD2	chr5	134294729	+
intron-3UTR	ENST00000517775	ENST00000510013	STK10	chr5	171583627	-	PCBD2	chr5	134294729	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000176763

STK10

chr5

171583627

ENST00000254908

PCBD2

chr5

134294729

1438

665

841

271

ENST00000176763

STK10

chr5

171583627

ENST00000512783

PCBD2

chr5

134294729

6050

665

841

271

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000176763	ENST00000254908	STK10	chr5	171583627	-	PCBD2	chr5	134294729	+	0.00471871	0.9952813
ENST00000176763	ENST00000512783	STK10	chr5	171583627	-	PCBD2	chr5	134294729	+	0.001404576	0.9985954

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Fusion Genomic Features for STK10-PCBD2

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
STK10	chr5	171583627	-	PCBD2	chr5	134294729	+	2.42E-13	1
STK10	chr5	171583627	-	PCBD2	chr5	134294729	+	2.42E-13	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for STK10-PCBD2

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:171583627/chr5:134294729)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

STK10

chr5:171583627

chr5:134294729

ENST00000176763

42_50

107

969.0

Nucleotide binding

ATP

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

STK10

chr5:171583627

chr5:134294729

ENST00000176763

573_947

107

969.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

STK10

chr5:171583627

chr5:134294729

ENST00000176763

750_884

107

969.0

Compositional bias

Note=Gln-rich

Hgene

STK10

chr5:171583627

chr5:134294729

ENST00000176763

36_294

107

969.0

Domain

Protein kinase

Hgene

STK10

chr5:171583627

chr5:134294729

ENST00000176763

175_224

107

969.0

Region

Note=Activation segment

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Fusion Gene Sequence for STK10-PCBD2

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>87436_87436_1_STK10-PCBD2_STK10_chr5_171583627_ENST00000176763_PCBD2_chr5_134294729_ENST00000254908_length(transcript)=1438nt_BP=665nt
CGGTGGGCGGGCGCGGGGACGGTCCCCTGGAACGGGTCCGAGGCTCTCGCAGGCAGGGCTGGGCCGGGCAGGAGCTGCGAGGCCGGCACA
AGGGAGGCGGCCCTGGGGACCTGACAGGGCGGGGGCGGGGGCGGGCACGCCGCCGCCTGCGCGGTTCCGGGTGCTCCCGGCGCGGCGCTG
CCCAGGGCACACTTGACCGAGGTCGGGCTGCGGGGAAAGGCGGGTCTGGGGAGAACCCCGAGAGACGCGGCGTCCTCCAACTCCTCCTCC
TTCTCCTCGCGGCCGCCGAAGCCACAGCCCGAGCCCGAGCCCGAGCCCGAGCCGGCGCCACCGCGCCCCCGGCCATGGCTTTTGCCAATT
TCCGCCGCATCCTGCGCCTGTCTACCTTCGAGAAGAGAAAGTCCCGCGAATATGAGCACGTCCGCCGCGACCTGGACCCCAACGAGGTGT
GGGAGATCGTGGGCGAGCTGGGCGACGGCGCCTTCGGCAAGGTTTACAAGGCCAAGAATAAGGAGACGGGTGCTTTGGCTGCGGCCAAAG
TCATTGAAACCAAGAGTGAGGAGGAGCTGGAGGACTACATCGTGGAGATTGAGATCCTGGCCACCTGCGACCACCCCTACATTGTGAAGC
TCCTGGGAGCCTACTATCACGACGGGAAGCTGTGGGCATTTGGCTTTATGTCCCGAGTTGCCCTACAAGCAGAGAAGATGAATCATCACC
CAGAATGGTTCAATGTATACAACAAGGTCCAGATAACTCTCACCTCACATGACTGTGGTGAACTGACCAAAAAAGATGTGAAGCTGGCCA
AGTTTATTGAAAAAGCAGCTGCTTCTGTGTGATTTCTTCCAAAATACATGTAAAATCTTGTACACATCTTAGCTGCAATGTATGTTGAAG
GAAATTTATGTGAACAAATAGAGTTGTTCTTTTTCTCTTTTTTTTAAGACAGAGTGTTGCTCTGTCGCCCAGGCCAGAGTGCAGTGGTAT
GATCTCGGCTCACTGTAACCTCCGCCTCCCAGGTTCAGGTGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAAGCACGTGTCA
CCACGCCTGGCTAATTTTTGTATTTTTAGTATAGACAGGGTTTTACCACGTTGGTCAGGCTGGTCTCGAACTCCTGACCTCGTGATCCGC
CTGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCACCATGCCTGGCTGTTGAATTGTTCTTAAGGCATCATATCTAGAAGCA
AAGAAAAAAGAAAAATAACAATTTAAGTTGTGTAAATTGTTTGCCTTTATATATTACATTTGGTAAAATCAGTGCTTAAATACGCAATGA

>87436_87436_1_STK10-PCBD2_STK10_chr5_171583627_ENST00000176763_PCBD2_chr5_134294729_ENST00000254908_length(amino acids)=271AA_BP=213
MERVRGSRRQGWAGQELRGRHKGGGPGDLTGRGRGRARRRLRGSGCSRRGAAQGTLDRGRAAGKGGSGENPERRGVLQLLLLLLAAAEAT
ARARARARAGATAPPAMAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEE
LEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWAFGFMSRVALQAEKMNHHPEWFNVYNKVQITLTSHDCGELTKKDVKLAKFIEKAAAS

--------------------------------------------------------------
>87436_87436_2_STK10-PCBD2_STK10_chr5_171583627_ENST00000176763_PCBD2_chr5_134294729_ENST00000512783_length(transcript)=6050nt_BP=665nt
CGGTGGGCGGGCGCGGGGACGGTCCCCTGGAACGGGTCCGAGGCTCTCGCAGGCAGGGCTGGGCCGGGCAGGAGCTGCGAGGCCGGCACA
AGGGAGGCGGCCCTGGGGACCTGACAGGGCGGGGGCGGGGGCGGGCACGCCGCCGCCTGCGCGGTTCCGGGTGCTCCCGGCGCGGCGCTG
CCCAGGGCACACTTGACCGAGGTCGGGCTGCGGGGAAAGGCGGGTCTGGGGAGAACCCCGAGAGACGCGGCGTCCTCCAACTCCTCCTCC
TTCTCCTCGCGGCCGCCGAAGCCACAGCCCGAGCCCGAGCCCGAGCCCGAGCCGGCGCCACCGCGCCCCCGGCCATGGCTTTTGCCAATT
TCCGCCGCATCCTGCGCCTGTCTACCTTCGAGAAGAGAAAGTCCCGCGAATATGAGCACGTCCGCCGCGACCTGGACCCCAACGAGGTGT
GGGAGATCGTGGGCGAGCTGGGCGACGGCGCCTTCGGCAAGGTTTACAAGGCCAAGAATAAGGAGACGGGTGCTTTGGCTGCGGCCAAAG
TCATTGAAACCAAGAGTGAGGAGGAGCTGGAGGACTACATCGTGGAGATTGAGATCCTGGCCACCTGCGACCACCCCTACATTGTGAAGC
TCCTGGGAGCCTACTATCACGACGGGAAGCTGTGGGCATTTGGCTTTATGTCCCGAGTTGCCCTACAAGCAGAGAAGATGAATCATCACC
CAGAATGGTTCAATGTATACAACAAGGTCCAGATAACTCTCACCTCACATGACTGTGGTGAACTGACCAAAAAAGATGTGAAGCTGGCCA
AGTTTATTGAAAAAGCAGCTGCTTCTGTGTGATTTCTTCCAAAATACATAAGTCTGAGAGGCTAAACTTGATGGCTGTGTTAACATATGT
CACGTGTAGCACAGTGGAGAAAGCAGGATATGGCTCATAATGACAGTGGTGAAGACCTGCGAATGAAGTTGCTAGTTATCACCTACATTA
GGGTTTGACATAGGTCTATGTTATGGGTCGCTGCATCTGCTGGAACTCACAGACTTTACTATAGAGAATCAAAGATCCCGTATCCGAAGT
CTATGGAAATGCTCATGGTGGTAAATTCCAACAGAATGAAACACCAAACTTGCTTAAAGTAACTCACGTTTCAATTTGAAAGAGATATTG
TCAAAATTGGAGGCCCCCAGGTTCCTGTCTGTTCCAAATCTTTGCATGATGACAGTGGTTTCTCTGATGTGGTAAGCTTTGGCTTTCTTC
TGTTTTCTTTCTAAAAGATCACTGGAGTAGAGAGGAGTTAAACAGACATGACCTTTGACCTCTTGCATGACCTCCACAGATAGCAAACCG
GGCCGACACATGGTTGACGATGTCCTTTTCTACAATGAAGTTAATGAAAGTTCTGAAAATAGTGATTACTTTCTGACATTGATAGGATTT
AGGAAACCTCTGGATAAATAGCTTAAGCATGGCTGTTTATGTTTTTGCTATAGACAAAAAGCAGCAGCATGTACATTGTATTTGGACACA
AGCCTGCCTCGGTTAATATATTGAACTATTGGACCACTAGGGTTAGTAGGGAGCGGTCTGTACACTTTCTGATTCAGCATTCAGAAACAT
TCTAGGTGGACTCTGTAGCTTTCAGTTTTGTAAAGTTATCAGAAAAACATCGGGAGGGTTTGGCCATCATATGTGAGCTTTGTGTTTCAA
TGCCAGTTACTCAGGATTAGTAAATTAATGACTGTCCAGAGGACTTCAGGGTCACCAAGCTGCTGCACCTGCCATTGGCTGACTCTCCCC
GGCTATCTGTGGCTGAGATGGTGCTGCTTAGGTCACGCAGAGCATGAGCTGCTGCTGAAAGGGCACAGGAGATGGCCCTTGGGCTTCTCA
TCCCAGGATGCCTGCCCTGCCCACCAATCCATGAGAAGATATGTATGATTTCAGTAGGCCCTGGATCAGCTTGTCACCTCTGGTTTCCTG
TTTGCTTTCCACTCACTCAGCTGGAGTTTCATTTCCAGACTAAAGTCTTCATCATTGGCTTCAGAAACAGCATTCATCTGTGGCTGTGCT
GATGTAGTACACCAAGAACAACTGGGCTCTTCTCTGTCACTTTCAGTGGGCTACCTTCCCTCACCTCTCCAAGCAGCATGAAAGAATTCT
TTACATTTTTAATCTCTTTTTTGTTTTTCCCTGAAAGTATGCTTTGGTGCTTAAAGAGAGAAGTCACAAAAGTATACTACTGAGTTTCCT
GGAGATGAAATCCTGTTGTCCCTAGCTATGTGAATGAGCACAGGGATCCCTGATGCCATTATTTTGTATATTCATACGGCACACACTTAC
TGAGGGCCTTCTGTGTGCCCTAGGGGATTGAGCACAGTGACATATCAGGGCAGGTAGAAACAGATGGAGAGCTGATGCGGGCTGTCTTAG
AGCAGCTGCCCCAGGAGGCCCCTGTGGATGGATGTTGGGCAGGAGCCCTGAGACGTTAGGGGCATATAACTAAAGGACATAGCAGGAGTT
ATAGGAGGAGCTGATCCCTGAGGGAAACAATGAAGACGGAGAAGATGGGGCTAAAGTTTGAATTGTGGGGACATTAATCACAGTGATTCT
TAAAACTTTGCTGTTGATGATTTTAAATGGAGAAAATGAGTACGTAAGATGTTATTTCCCAGTTCAGTATATTGGTTGCCCACAAAGTAT
TTTCCTACCATGAATGGTCATATATACTTGTTGTAGAATACCAGGGACAGCAGAGATGGTGGGGTAGTTACTTCCTTTTCTTACAGCCCA
AGAACTTTGGTGTCCAGGAGATTGACCAATTTAGCCACTGAGCATTTAATACAACACAGGGCTACCCAGATCCCACTGTCCTGATTTGCC
CTGAAAGCCAAAGGAGTTAGGAGAAGGTGAGTGGGGAGAATATATTAATCCTGAGAGTTGAACAGAGCAAAAATCCCTATTACTTTTGTA
CTTAAAACATCTCTGCCACATGTGCTCACTCTTTATATTCTGTTTAGGTGGTTTATATGTGCACATCCCATCCTATGCCTGCAGTTAGCC
AACTCAGGGTTTATATTGCCTCCTTTCTTTTTTTCTTTTTTTTTTTTTTTTTAAGAGATGGGGTCTCATTCTATCATGCAGACTGGAGTG
CAGTGGTGTGATCACAGCTCATTGTAACCTCCAACGCCTGGACTAAAGTGATCCTCCTACCTTGGCCTCTCTGGTAGCTGGGACTACAGG
TGCATGCCACCACACCCACCTAATTTTTTTTATTTTTATTTTTTGTAGAGACAGTCTCACTATCTTGCTCAGGCTAGTCCTGAACTCCTG
GGCTCAAGTTATCTTGCTGCCTCAGCCTCCCATGGGTAATTTTTATTTCCTTTTTTTTTTTTTTTGGAGATGGAGTTTCGCTCTTGTCGC
CCAGGCTGGAGTGCAATGGCACGATCTTGGCTCACTGCAGTCTCCACCTCCTGGGTTCAAGTGATTCTCCATCCTCAGCCTCCTGAGTAG
CTGAGATTACAGGCAACTGCCACCATGCGCGGCTAATTTATGTATTTTTTTTTAGTAAGAGATGGGGTTTCACCATGTTGGCCAGACTAG
TCTTAAACTCCTGACCTCAAGCGACCTGCCTGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGCATGAGCCGCTATGCCTCGTCGCTGAT
TTTTATTTCTTATTTTTTTTTTAGAGATGGGGGTCTCACTATGTTGCTCAGGCTGATCTCAAACTCCTGGCCTCAAGTGATCCTCCCACC
TTAGCCTCCCAAGTTGCTGGGATTATAAGTGTGAGCCACTATCCCTACCTCACTATTACCTTCTTTGCTTCTCTTGTTTTCTTTTGTTCT
AAGTCAAACCCATCACAATCTTTTCTTGTCCTTCCAGGTGTTTTCCAGTGCTGTGCCCTGGATGTGCTCTCTTTCTCTTAGAGCCCAGAG
AACTTGCTTTTCCCCCTTATATATGACCCTTAACTTTTTCTAACACATTATTAAGGGCCTGTGTCTATCAGCTGGGGGCACTTCTTGAAG
GGAGGGCCTTTGTGTGGTCTGTTTCTAGTGACTTCCAGCTTTAACCCAGAGCCTCATGATTGCTGGGTGCCCATAGCCTTTTTGCTGAAT
GGAGGCACTCAGTCTCCTTGGGAAGAGAGAATCCATGATAGACCCACTTGGGAGCTCCCCACTTCAGGGGCCTACACACTGGTAATGCAA
CAGAATGCCCAAGAGTGACCTCATAAAGCAAGGATTCCCTTCGTGGCCCCTTCTCTGCTGCCTCTCAGAATCCAGACGCTAAGGAAAATC
CCTAAGCAGAGATTTTCTGTTGGATGCTAAAAGCAAGGAATAAAAGTTGAAAATTTGGAAAATGTCTCAACACCGTCACCAGCGCCACTC
GAGAGTCATTTCTAGTTCACCAGTTGACACTACATCGGTGGGATTTTGCCCAACATTCAAGAAATTTAAGTAAATATTATCTATCTCCAT
TGCCTGTTAAGAAATGTGCTAGTAGAAGTGTGAGGGCAGGGTGTCAGTGTTCTCTCAGCCTCTTCCCTCAGATACTCGTCTGCTTACCAA
AATAAGTTGCATGTCCTTGACAATCTGGTTTCTATGATTGGTGAGGCTGGCATGCTATTACCTTTATGTGCCCTGTAGACTTGAATGACC
AGTTTGACCAGTTTGACTGTTAGATAATCTGAAGGCTTTTCTCTTTTTTTATAATAGACCCCATCTCAAATCAGATAATGAAAATTACAT
ATCTTGATATATTAGAAAAGTATATACATTCTGGCTGGGCACGGTGGCTCACACCTGTAATCCCTGCACTTTGAGAGGCTGGGGCGGATC
ACTTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACGTGGCGAAACCCCATCTCTACTAAAAATACACAGATTAGCCCGGAGTGATGGTG
TGCACCTGTTGTCCCAGCTACTCAGGATGCTGAGGCAGGAGAATCCCTTTAACCTGGGGGGCGAAGGTTGCAGTGAGCCAAGATTGCACC
ACTGCACTCCAGCCTGGGTGACAGAACGAGACTCTGTCTCAGAAAAAAAAAAAAAGAAAAGGAAAAAGAAAAATATATATTCTATATTTT
TTTAACTTATGAGAATGTGTTCATTTCATTTGTAACATATAATGGGAAACAGTAATACGTACTCTGAGAAAAATTGCAAAGCACAGATAA
ATGGAAATAAACAGGAAAAAGAATCACCTATAACCTCACCATCCATAGACAGACACTGTTAAAATTTTGGCATATTTCCTGCTGATTTTT
TCTACTGCTGATTTTTGCACAGGTGAGATAATTTTGAACAGAGAATTTTGTATCTTTGGTTTTTGTGTTTTGCTGCACACAAAAACAAAA
GATATAAAAATGGATCATAAACATTTTTCTAAATCCTGAAAAATGCATAGACATATTTTAGTGCCTGTATTTCACAAGATGGACATACCA
TAATTTACTTACACAGTCCTTTTTGTTAGATGTTTAAGTTGTTTTCAAGCTTCTCAGTGCTGGAAAAAATACTGAGATAGACATGTTTAG
TTGAAGTTATTTCATTTCAGGTTATATTATCTTGGGTCAGAGAATGAATGGTTCTCAGGCTTTTCAAAAGAGCTGGTCAGTTTTTATGCC
TCTGGCAGTTTTTGAGAGTGCTCAATCATACTACACTGTTGCCAGCATTAGATCTTATCACATTTAAGTCATTGCTAATTTTATAAACAA
AAACAATGGTTTTACTTTGCATCTCCCTGATTGGTATTGCTGTAGAACATATTTGGAGAAGTTTGTTTGTCTTTGGTGTTTATTTCATGA
ATAGATTGTGTGCCCATTTTCTCTTGGGGTATTCAGTTTTTTATTACTGATGTGAGCATGTGTATGGGTGATTATTTGATGATTATCAGT
TTTGCTTAGTAGACTGGCAATATTTAGTCTTGCTGTCACTGTGTTCCCAGTGCCTACTAGATTGCTTGATATGTAGTTGCCACTCAATAA

>87436_87436_2_STK10-PCBD2_STK10_chr5_171583627_ENST00000176763_PCBD2_chr5_134294729_ENST00000512783_length(amino acids)=271AA_BP=213
MERVRGSRRQGWAGQELRGRHKGGGPGDLTGRGRGRARRRLRGSGCSRRGAAQGTLDRGRAAGKGGSGENPERRGVLQLLLLLLAAAEAT
ARARARARAGATAPPAMAFANFRRILRLSTFEKRKSREYEHVRRDLDPNEVWEIVGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEE
LEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWAFGFMSRVALQAEKMNHHPEWFNVYNKVQITLTSHDCGELTKKDVKLAKFIEKAAAS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for STK10-PCBD2

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for STK10-PCBD2

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for STK10-PCBD2

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source