Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:STK39-ITGB6 (FusionGDB2 ID:87556)

Fusion Gene Summary for STK39-ITGB6

Fusion gene summary

Fusion gene information	Fusion gene name: STK39-ITGB6
	Fusion gene ID: 87556
		Hgene	Tgene
	Gene symbol	STK39	ITGB6
	Gene ID	27347	3694
	Gene name	serine/threonine kinase 39	integrin subunit beta 6
	Synonyms	DCHT\|PASK\|SPAK	AI1H
	Cytomap	2q24.3	2q24.2
	Type of gene	protein-coding	protein-coding
	Description	STE20/SPS1-related proline-alanine-rich protein kinaseSTE20/SPS1 homologSte20-like protein kinaseproline-alanine-rich STE20-related kinaseserine threonine kinase 39 (STE20/SPS1 homolog, yeast)serine/threonine-protein kinase 39small intestine SPAK-li	integrin beta-6integrin, beta 6
	Modification date	20200313	20200313
	UniProtAcc	.	P18564
	Ensembl transtripts involved in fusion gene	ENST00000355999, ENST00000487143,	ENST00000409872, ENST00000409967, ENST00000428609, ENST00000485635, ENST00000283249,
Fusion gene scores	* DoF score	12 X 9 X 9=972	8 X 6 X 8=384
	# samples	12	10
	** MAII score	log2(12/972*10)=-3.01792190799726 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/384*10)=-1.94110631094643 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: STK39 [Title/Abstract] AND ITGB6 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	STK39(168921829)-ITGB6(160994710), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	STK39	GO:0018105	peptidyl-serine phosphorylation	24393035
Hgene	STK39	GO:0018107	peptidyl-threonine phosphorylation	24393035
Hgene	STK39	GO:0023014	signal transduction by protein phosphorylation	24393035
Hgene	STK39	GO:0035556	intracellular signal transduction	24393035
Hgene	STK39	GO:1901017	negative regulation of potassium ion transmembrane transporter activity	24393035
Hgene	STK39	GO:1901380	negative regulation of potassium ion transmembrane transport	24393035
Hgene	STK39	GO:1905408	negative regulation of creatine transmembrane transporter activity	25531585
Hgene	STK39	GO:2000650	negative regulation of sodium ion transmembrane transporter activity	25531585
Tgene	ITGB6	GO:0033627	cell adhesion mediated by integrin	17158881
Tgene	ITGB6	GO:1901388	regulation of transforming growth factor beta activation	22278742

Fusion gene breakpoints across STK39 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ITGB6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-E2-A14Z-01A	STK39	chr2	168921829	-	ITGB6	chr2	160994710	-

Top

Fusion Gene ORF analysis for STK39-ITGB6

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000355999	ENST00000409872	STK39	chr2	168921829	-	ITGB6	chr2	160994710	-
5CDS-intron	ENST00000355999	ENST00000409967	STK39	chr2	168921829	-	ITGB6	chr2	160994710	-
5CDS-intron	ENST00000355999	ENST00000428609	STK39	chr2	168921829	-	ITGB6	chr2	160994710	-
5CDS-intron	ENST00000355999	ENST00000485635	STK39	chr2	168921829	-	ITGB6	chr2	160994710	-
5UTR-3CDS	ENST00000487143	ENST00000283249	STK39	chr2	168921829	-	ITGB6	chr2	160994710	-
5UTR-intron	ENST00000487143	ENST00000409872	STK39	chr2	168921829	-	ITGB6	chr2	160994710	-
5UTR-intron	ENST00000487143	ENST00000409967	STK39	chr2	168921829	-	ITGB6	chr2	160994710	-
5UTR-intron	ENST00000487143	ENST00000428609	STK39	chr2	168921829	-	ITGB6	chr2	160994710	-
5UTR-intron	ENST00000487143	ENST00000485635	STK39	chr2	168921829	-	ITGB6	chr2	160994710	-
In-frame	ENST00000355999	ENST00000283249	STK39	chr2	168921829	-	ITGB6	chr2	160994710	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000355999

STK39

chr2

168921829

ENST00000283249

ITGB6

chr2

160994710

5341

2011

454

3270

938

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000355999	ENST00000283249	STK39	chr2	168921829	-	ITGB6	chr2	160994710	-	0.000336759	0.99966323

Top

Fusion Genomic Features for STK39-ITGB6

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for STK39-ITGB6

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:168921829/chr2:160994710)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	ITGB6 P18564
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (PubMed:17545607, PubMed:17158881). It recognizes the sequence R-G-D in its ligands (PubMed:17545607, PubMed:17158881). Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion (PubMed:17545607, PubMed:17158881). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447). {ECO:0000269\|PubMed:15184403, ECO:0000269\|PubMed:17158881, ECO:0000269\|PubMed:17545607, ECO:0000269\|PubMed:22278742, ECO:0000269\|PubMed:28117447}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1. {ECO:0000269\|PubMed:15194773, ECO:0000269\|PubMed:9426447}.; FUNCTION: (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1 (PubMed:24367260). {ECO:0000269\|PubMed:24367260}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

STK39

chr2:168921829

chr2:160994710

ENST00000355999

12_53

435

546.0

Compositional bias

Note=Ala/Pro-rich

Hgene

STK39

chr2:168921829

chr2:160994710

ENST00000355999

63_337

435

546.0

Domain

Protein kinase

Hgene

STK39

chr2:168921829

chr2:160994710

ENST00000355999

360_366

435

546.0

Motif

Nuclear localization signal

Hgene

STK39

chr2:168921829

chr2:160994710

ENST00000355999

387_391

435

546.0

Motif

Note=Caspase cleavage related site

Hgene

STK39

chr2:168921829

chr2:160994710

ENST00000355999

69_77

435

546.0

Nucleotide binding

ATP

Tgene

ITGB6

chr2:168921829

chr2:160994710

ENST00000283249

456_619

369

789.0

Region

Note=Cysteine-rich tandem repeats

Tgene

ITGB6

chr2:168921829

chr2:160994710

ENST00000409872

456_619

369

789.0

Region

Note=Cysteine-rich tandem repeats

Tgene

ITGB6

chr2:168921829

chr2:160994710

ENST00000283249

456_501

369

789.0

Repeat

Note=I

Tgene

ITGB6

chr2:168921829

chr2:160994710

ENST00000283249

502_543

369

789.0

Repeat

Note=II

Tgene

ITGB6

chr2:168921829

chr2:160994710

ENST00000283249

544_582

369

789.0

Repeat

Note=III

Tgene

ITGB6

chr2:168921829

chr2:160994710

ENST00000283249

583_619

369

789.0

Repeat

Note=IV

Tgene

ITGB6

chr2:168921829

chr2:160994710

ENST00000409872

456_501

369

789.0

Repeat

Note=I

Tgene

ITGB6

chr2:168921829

chr2:160994710

ENST00000409872

502_543

369

789.0

Repeat

Note=II

Tgene

ITGB6

chr2:168921829

chr2:160994710

ENST00000409872

544_582

369

789.0

Repeat

Note=III

Tgene

ITGB6

chr2:168921829

chr2:160994710

ENST00000409872

583_619

369

789.0

Repeat

Note=IV

Tgene

ITGB6

chr2:168921829

chr2:160994710

ENST00000283249

731_788

369

789.0

Topological domain

Cytoplasmic

Tgene

ITGB6

chr2:168921829

chr2:160994710

ENST00000409872

731_788

369

789.0

Topological domain

Cytoplasmic

Tgene

ITGB6

chr2:168921829

chr2:160994710

ENST00000283249

710_730

369

789.0

Transmembrane

Helical

Tgene

ITGB6

chr2:168921829

chr2:160994710

ENST00000409872

710_730

369

789.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ITGB6

chr2:168921829

chr2:160994710

ENST00000283249

131_371

369

789.0

Domain

Note=VWFA

Tgene

ITGB6

chr2:168921829

chr2:160994710

ENST00000409872

131_371

369

789.0

Domain

Note=VWFA

Tgene

ITGB6

chr2:168921829

chr2:160994710

ENST00000283249

22_709

369

789.0

Topological domain

Extracellular

Tgene

ITGB6

chr2:168921829

chr2:160994710

ENST00000409872

22_709

369

789.0

Topological domain

Extracellular

Top

Fusion Gene Sequence for STK39-ITGB6

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>87556_87556_1_STK39-ITGB6_STK39_chr2_168921829_ENST00000355999_ITGB6_chr2_160994710_ENST00000283249_length(transcript)=5341nt_BP=2011nt
AAACTAGAAGGACTGCGATTAGATTAGGCAAGGTGGGAAAGGGATACCGGCAAGTAAAGCGCCGGAAACTTACAACTTGGGTTATTTTCT
AACTGGCGTCTTGCAAAGGGACACCATGTAGGTATCCCGCTCGTCAACTTGTAAATGAACTTCAGGTTCTCTTTGGTGGCAGGAGAATTC
TGAATGTGAGAACCTGGCGGCCGTTCAACGACCCCGCCCTCGGGGTCCCCAGGGGGCGTCCTCCGGCAAGCCTGATCGTCTGGGGCCAAG
GCGCAGGGCGAGCAGGGAGGGAGGAGGAGAACCAGGGCCGGTGGCCCCGAAAGCACACACAAAGCGGCCTGACTCCTTTGGTGGGAACTT
CCCCGGCCGCCAGCGGAGCGGGAGCGGGAGGGGGCGGCGGAGAGGGGGGGCGGCGGTTCCCCTCGCCGAGGCGGAGAACAGCGCGCGCTA
GGCTCTGGGCGCGCGGCGAGCGCAGCGGCCGCCGCCTCCTCCCTTCCCCGCCTCCGCCGGCGCTGCCTCCTCCCTCCGCCCAGCTCGGCC
TCCCTTGCTCCCTCCCCTCCTAGCTGGCTTCGGCGGGGACGGCGGCGGCGGCGGCGGGCGGGGAGGGCGTGCGCCGGCCGAGAGGTGTCG
GCGGCGAGGCAAAGGAAGTTTCAAGTGGAAGGTCGTCCGTCGGCCGGCGCGTCCTCCTGCTCTCCTCCGCAGCATCATGGCGGAGCCGAG
CGGCTCGCCCGTGCACGTCCAGCTTCCCCAGCAGGCGGCCCCGGTGACAGCGGCGGCGGCGGCGGCCCCGGCGGCCGCGACAGCAGCGCC
GGCCCCGGCAGCTCCCGCGGCCCCGGCCCCGGCCCCGGCCCCGGCGGCACAGGCTGTCGGCTGGCCCATCTGCAGGGACGCGTACGAGCT
GCAGGAGGTTATCGGCAGTGGAGCTACTGCTGTGGTTCAGGCAGCCCTATGCAAACCCAGGCAAGAACGTGTAGCAATAAAACGGATCAA
CTTGGAAAAATGCCAGACCAGTATGGATGAACTATTAAAAGAAATTCAAGCCATGAGTCAGTGCAGCCATCCCAACGTAGTGACCTATTA
CACCTCTTTTGTGGTCAAAGATGAACTTTGGCTGGTCATGAAATTACTAAGTGGAGGTTCAATGTTGGATATCATAAAATACATTGTCAA
CCGAGGAGAACACAAGAATGGAGTTCTGGAAGAGGCAATAATAGCAACAATTCTTAAAGAGGTTTTGGAAGGCTTAGACTATCTACACAG
AAACGGTCAGATTCACAGGGATTTGAAAGCTGGTAATATTCTTCTGGGTGAGGATGGTTCAGTACAAATAGCAGATTTTGGGGTAAGTGC
GTTCCTAGCAACAGGGGGTGATGTTACCCGAAATAAAGTAAGAAAAACATTCGTTGGCACCCCATGTTGGATGGCTCCTGAAGTCATGGA
ACAGGTGAGAGGCTATGACTTCAAGGCTGACATGTGGAGTTTTGGAATAACTGCCATTGAATTAGCAACAGGAGCAGCGCCTTATCACAA
ATATCCTCCCATGAAAGTGTTAATGTTGACTTTGCAAAATGATCCACCCACTTTGGAAACAGGGGTAGAGGATAAAGAAATGATGAAAAA
GTACGGCAAGTCCTTTAGAAAATTACTTTCACTGTGTCTTCAGAAAGATCCTTCCAAAAGGCCCACAGCAGCAGAACTTTTAAAATGCAA
ATTCTTCCAGAAAGCCAAGAACAGAGAGTACCTGATTGAGAAGCTGCTTACAAGAACACCAGACATAGCCCAAAGAGCCAAAAAGGTAAG
AAGAGTTCCTGGGTCAAGTGGTCACCTTCATAAAACCGAAGACGGGGACTGGGAGTGGAGTGACGACGAGATGGATGAGAAGAGCGAAGA
AGGGAAAGCAGCTTTTTCTCAGGAAAAGTCACGAAGAGTAAAAGAAGAAAATCCAGAGATTGCAGTGAGTGCCAGCACCATCCCCGAACA
AATACAGTCCCTCTCTGTGCACGACTCTCAGGAACTGCGGTCTGAGGTGGAACTGGAAGTATTAGGAGACACTGAAGGACTCAACTTGTC
ATTTACAGCCATCTGTAACAACGGTACCCTCTTCCAACACCAAAAGAAATGCTCTCACATGAAAGTGGGAGACACAGCTTCCTTCAGCGT
GACTGTGAATATCCCACACTGCGAGAGAAGAAGCAGGCACATTATCATAAAGCCTGTGGGGCTGGGGGATGCCCTGGAATTACTTGTCAG
CCCAGAATGCAACTGCGACTGTCAGAAAGAAGTGGAAGTGAACAGCTCCAAATGTCACCACGGGAACGGCTCTTTCCAGTGTGGGGTGTG
TGCCTGCCACCCTGGCCACATGGGGCCTCGCTGTGAGTGTGGCGAGGACATGCTGAGCACAGATTCCTGCAAGGAGGCCCCAGATCATCC
CTCCTGCAGCGGAAGGGGTGACTGCTACTGTGGGCAGTGTATCTGCCACTTGTCTCCCTATGGAAACATTTATGGGCCTTATTGCCAGTG
TGACAATTTCTCCTGCGTGAGACACAAAGGGCTGCTCTGCGGAGGTAACGGCGACTGTGACTGTGGTGAATGTGTGTGCAGGAGCGGCTG
GACTGGCGAGTACTGCAACTGCACCACCAGCACGGACTCCTGCGTCTCTGAAGATGGAGTGCTCTGCAGCGGGCGCGGGGACTGTGTTTG
TGGCAAGTGTGTTTGCACAAACCCTGGAGCCTCAGGACCAACCTGTGAACGATGTCCTACCTGTGGTGACCCCTGTAACTCTAAACGGAG
CTGCATTGAGTGCCACCTGTCAGCAGCTGGCCAAGCCCGAGAAGAATGTGTGGACAAGTGCAAACTAGCTGGTGCGACCATCAGTGAAGA
AGAAGATTTCTCAAAGGATGGTTCTGTTTCCTGCTCTCTGCAAGGAGAAAATGAATGTCTTATTACATTCCTAATAACTACAGATAATGA
GGGGAAAACCATCATTCACAGCATCAATGAAAAAGATTGTCCGAAGCCTCCAAACATTCCCATGATCATGTTAGGGGTTTCCCTGGCTAT
TCTTCTCATCGGGGTTGTCCTACTGTGCATCTGGAAGCTACTGGTGTCATTTCATGATCGTAAAGAAGTTGCCAAATTTGAAGCAGAACG
ATCAAAAGCCAAGTGGCAAACGGGAACCAATCCACTCTACAGAGGATCCACAAGTACTTTTAAAAATGTAACTTATAAACACAGGGAAAA
ACAAAAGGTAGACCTTTCCACAGATTGCTAGAACTACTTTATGCATGAAAAAAGTCTGTTTCACTGATATGAAATGTTAATGCACTATTT
AATTTTTTTCTCTTTGTTGCTTCAAAATGAGGTTGGTTTAAGATAATAATAGGACATCTGCAGATAAGTCATCCTCTACATGAAGGTGAC
AGACTGTTGGCAGTTTCAAAATAATCAAGAAGAGAAATATCCTTAGCAAAGAGATGACTTTGGGGATCATTTGAGGAATACTAACTCTGT
TGCATTAATGCTTCAAAAAATCATCAAATGATTCATGGGGGCCTGATTTGCATTTGAAAAATGTTTGAAATTAGAGTCTCATTTGTTTCA
GGAATGCAGCTACCTGAGTTTTTTGTCTCGGCAAAGTCACAAAGCCCATATACTCACATTGTGTGTCTATACTTGCCAATTAATTCTAAA
CTTGTAGGAAATATGCCCTCTCTTAAAGGAGAATTTTTTTTAAATCTCTGAGAAATGAGATTCTGAGTTTATTTCAGCTAAAAGGTTGCA
ATTCTTCTGAAGATATCTCAAATATAAGGTTGAAAGTTAAGTGTTAATAATTTTTGTGAATTTATACACACCTAAACGTTAAGTACACAA
ATATTTTATTTGTTTTACAAATAAGGAATAAGTAATTTATAAATTAAGAAGTTACCTATAAAAATAAAAAGATAACAACCCTATCATATA
GCTTATTTTTAAATTACCTGAAAAACGATATTCTACACTGTTTCCTTTTTGACTCTGAGTTTTCAAACTGTTACTTCTCCCATATTTCTC
AATCCATTTCACTCAGTTGCACAGTCTTTTAAACCCTGTAATTGTCATACCAAAGTTTCTTTTTAAAAAAAAATTACTTTAAATGCTTAG
TTTATTCAAAGAGCGATCCAATAATATAAAAGGAACATGTGTTAAACACAATAAAATTTTAAATGGCTCTAAATCAAGCACATCAAGAGT
ATACAAGTCTTAAAGGCTTTTTAATACATACTCTTTTCCCATCTATGTAACCCAACTTGCACATTTCAGCTGCATGTGGTGAATATGCAT
CATATATTTACTTTAAGAGGTAAGATTTTACTTGCAAAATACATGTGCAAATTAGGGATCCATCAGTTGATGGAAGAGATGGACTCTAGA
ATATTATTTCTTGTGGTTATTACTCCTTTACAAAGCACTTTCGTCTCACTTGATCCTCATAAGGAAACTAAGGCTCAGAATGAGTAGAGC
TGGGTTCAGAATCTAGCTCTTCTAACTCCAAGCCATCTCCTCTTTCCACTGCAGGAAACTGCCTCTTTTGTCAGTGAAATAATAGAAAGA
TTGTGTTAGTTAAGTGATAACTGTCATTTGTTTGAAAATGTTCGAGACTGAACAAATAGCATTTAAACTGCTGGCATATAGATGAGATAT
TGTACTTTTGTGCAATGTTTATTACCTTTGATTAAATTGTAATGTGAAGCTTTTACTAGGTGAATAGTTCATTATGTAGTGGAGGCTTCG
TGGTTGTCCATTGAATTGTCACAGCAAAATCTATAAGTTTCTTCAATTCTACAAGATAGATCCATATACCTTTGATCACTTGGAGACTCT
TTTTTTGCTGGTTTCTAGATAACTCAGGTAAATCAGACCTTTACAGAGTACAGGGCTAGGTGAAAGAATTACTGAAAAATCACCTTGAAA
ATCCGAAGGGCTGATATACCCTTTATGTTCCTGACTGATGCGCAGAACCTGGGGGAAATCTACAGCAATATACAGGTTGCAATGCTGATA
ACACAACAGCAATCCTCTCCTCTACGTGGACTTACTGTTGTTTTTTTAATTATTATTGGAATGGGATTTTAGAAAATAGAAGTTACCTTT
GTGTGTGTTTTAGGGAAGGTAGAGAAGAATCTGCTCTTTCTCTGAATACTGTTTTGACCCCAGGCAGGACCTTGGAAAGGCCAAAACATT
AACAGTAGTACTTCTGTTCACTGAAGAGTTATGTTACATGAAGATAAAATGGTTTTGTCGTGTTTATTATTGTATTTTGTGTTGATATAA

>87556_87556_1_STK39-ITGB6_STK39_chr2_168921829_ENST00000355999_ITGB6_chr2_160994710_ENST00000283249_length(amino acids)=938AA_BP=519
MGARRAQRPPPPPFPASAGAASSLRPARPPLLPPLLAGFGGDGGGGGGRGGRAPAERCRRRGKGSFKWKVVRRPARPPALLRSIMAEPSG
SPVHVQLPQQAAPVTAAAAAAPAAATAAPAPAAPAAPAPAPAPAAQAVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINL
EKCQTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRN
GQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKY
PPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRR
VPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAFSQEKSRRVKEENPEIAVSASTIPEQIQSLSVHDSQELRSEVELEVLGDTEGLNLSF
TAICNNGTLFQHQKKCSHMKVGDTASFSVTVNIPHCERRSRHIIIKPVGLGDALELLVSPECNCDCQKEVEVNSSKCHHGNGSFQCGVCA
CHPGHMGPRCECGEDMLSTDSCKEAPDHPSCSGRGDCYCGQCICHLSPYGNIYGPYCQCDNFSCVRHKGLLCGGNGDCDCGECVCRSGWT
GEYCNCTTSTDSCVSEDGVLCSGRGDCVCGKCVCTNPGASGPTCERCPTCGDPCNSKRSCIECHLSAAGQAREECVDKCKLAGATISEEE
DFSKDGSVSCSLQGENECLITFLITTDNEGKTIIHSINEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKEVAKFEAERS

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for STK39-ITGB6

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	ITGB6	chr2:168921829	chr2:160994710	ENST00000283249		7	15	731_758	369.0	789.0	HAX1
Tgene	ITGB6	chr2:168921829	chr2:160994710	ENST00000409872		8	16	731_758	369.0	789.0	HAX1

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	STK39	chr2:168921829	chr2:160994710	ENST00000355999	-	13	18	310_536	435.0	546.0	RELT

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for STK39-ITGB6

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for STK39-ITGB6

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source