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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:STK3-SULT1A3 (FusionGDB2 ID:87589)

Fusion Gene Summary for STK3-SULT1A3

check button Fusion gene summary
Fusion gene informationFusion gene name: STK3-SULT1A3
Fusion gene ID: 87589
HgeneTgene
Gene symbol

STK3

SULT1A3

Gene ID

8428

100526830

Gene nameserine/threonine kinase 24SLX1A-SULT1A3 readthrough (NMD candidate)
SynonymsHEL-S-95|MST3|MST3B|STE20|STK3HAST3|M-PST|ST1A3|STM|SULT1A3|TL-PST
Cytomap

13q32.2

16p11.2

Type of geneprotein-codingncRNA
Descriptionserine/threonine-protein kinase 24STE20-like kinase 3STE20-like kinase MST3epididymis secretory protein Li 95mammalian STE20-like protein kinase 3serine/threonine kinase 24 (STE20 homolog, yeast)sterile 20-like kinase 3Aryl sulfotransferase 1A3/1A4Catecholamine-sulfating phenol sulfotransferaseMonoamine-sulfating phenol sulfotransferasePlacental estrogen sulfotransferaseSLX1A-SULT1A3 readthrough (non-protein coding)Sulfotransferase 1A3Sulfotransferase 1A3/1A4Sulf
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000419617, ENST00000523601, 
ENST00000521768, 		ENST00000338971, 
ENST00000354723, ENST00000355544, 
ENST00000395137, ENST00000395138, 
ENST00000563322, 
Fusion gene scores* DoF score24 X 16 X 11=42241 X 2 X 1=2
# samples 302
** MAII scorelog2(30/4224*10)=-3.81557542886257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/2*10)=3.32192809488736
Context

PubMed: STK3 [Title/Abstract] AND SULT1A3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSTK3(99718695)-SULT1A3(30214011), # samples:1
STK3(99718694)-SULT1A3(29474665), # samples:1
Anticipated loss of major functional domain due to fusion event.STK3-SULT1A3 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
STK3-SULT1A3 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
STK3-SULT1A3 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
STK3-SULT1A3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSTK3

GO:0006468

protein phosphorylation

19604147

HgeneSTK3

GO:0042542

response to hydrogen peroxide

22291017

HgeneSTK3

GO:0046777

protein autophosphorylation

17046825|17657516


check buttonFusion gene breakpoints across STK3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SULT1A3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-66-2766-01ASTK3chr8

99718695

-SULT1A3chr16

30214011

+
ChimerDB4LUSCTCGA-66-2766STK3chr8

99718694

-SULT1A3chr16

29474665

+


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Fusion Gene ORF analysis for STK3-SULT1A3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000419617ENST00000338971STK3chr8

99718694

-SULT1A3chr16

29474665

+
5CDS-intronENST00000419617ENST00000354723STK3chr8

99718694

-SULT1A3chr16

29474665

+
5CDS-intronENST00000419617ENST00000355544STK3chr8

99718694

-SULT1A3chr16

29474665

+
5CDS-intronENST00000419617ENST00000395137STK3chr8

99718694

-SULT1A3chr16

29474665

+
5CDS-intronENST00000419617ENST00000395138STK3chr8

99718694

-SULT1A3chr16

29474665

+
5CDS-intronENST00000419617ENST00000563322STK3chr8

99718694

-SULT1A3chr16

29474665

+
5CDS-intronENST00000523601ENST00000338971STK3chr8

99718694

-SULT1A3chr16

29474665

+
5CDS-intronENST00000523601ENST00000354723STK3chr8

99718694

-SULT1A3chr16

29474665

+
5CDS-intronENST00000523601ENST00000355544STK3chr8

99718694

-SULT1A3chr16

29474665

+
5CDS-intronENST00000523601ENST00000395137STK3chr8

99718694

-SULT1A3chr16

29474665

+
5CDS-intronENST00000523601ENST00000395138STK3chr8

99718694

-SULT1A3chr16

29474665

+
5CDS-intronENST00000523601ENST00000563322STK3chr8

99718694

-SULT1A3chr16

29474665

+
Frame-shiftENST00000523601ENST00000338971STK3chr8

99718695

-SULT1A3chr16

30214011

+
Frame-shiftENST00000523601ENST00000354723STK3chr8

99718695

-SULT1A3chr16

30214011

+
Frame-shiftENST00000523601ENST00000355544STK3chr8

99718695

-SULT1A3chr16

30214011

+
Frame-shiftENST00000523601ENST00000395137STK3chr8

99718695

-SULT1A3chr16

30214011

+
Frame-shiftENST00000523601ENST00000395138STK3chr8

99718695

-SULT1A3chr16

30214011

+
Frame-shiftENST00000523601ENST00000563322STK3chr8

99718695

-SULT1A3chr16

30214011

+
In-frameENST00000419617ENST00000338971STK3chr8

99718695

-SULT1A3chr16

30214011

+
In-frameENST00000419617ENST00000354723STK3chr8

99718695

-SULT1A3chr16

30214011

+
In-frameENST00000419617ENST00000355544STK3chr8

99718695

-SULT1A3chr16

30214011

+
In-frameENST00000419617ENST00000395137STK3chr8

99718695

-SULT1A3chr16

30214011

+
In-frameENST00000419617ENST00000395138STK3chr8

99718695

-SULT1A3chr16

30214011

+
In-frameENST00000419617ENST00000563322STK3chr8

99718695

-SULT1A3chr16

30214011

+
intron-3CDSENST00000521768ENST00000338971STK3chr8

99718695

-SULT1A3chr16

30214011

+
intron-3CDSENST00000521768ENST00000354723STK3chr8

99718695

-SULT1A3chr16

30214011

+
intron-3CDSENST00000521768ENST00000355544STK3chr8

99718695

-SULT1A3chr16

30214011

+
intron-3CDSENST00000521768ENST00000395137STK3chr8

99718695

-SULT1A3chr16

30214011

+
intron-3CDSENST00000521768ENST00000395138STK3chr8

99718695

-SULT1A3chr16

30214011

+
intron-3CDSENST00000521768ENST00000563322STK3chr8

99718695

-SULT1A3chr16

30214011

+
intron-intronENST00000521768ENST00000338971STK3chr8

99718694

-SULT1A3chr16

29474665

+
intron-intronENST00000521768ENST00000354723STK3chr8

99718694

-SULT1A3chr16

29474665

+
intron-intronENST00000521768ENST00000355544STK3chr8

99718694

-SULT1A3chr16

29474665

+
intron-intronENST00000521768ENST00000395137STK3chr8

99718694

-SULT1A3chr16

29474665

+
intron-intronENST00000521768ENST00000395138STK3chr8

99718694

-SULT1A3chr16

29474665

+
intron-intronENST00000521768ENST00000563322STK3chr8

99718694

-SULT1A3chr16

29474665

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000419617STK3chr899718695-ENST00000354723SULT1A3chr1630214011+1727825451340431
ENST00000419617STK3chr899718695-ENST00000355544SULT1A3chr1630214011+1722825451340431
ENST00000419617STK3chr899718695-ENST00000395137SULT1A3chr1630214011+1429825451340431
ENST00000419617STK3chr899718695-ENST00000338971SULT1A3chr1630214011+1449825451340431
ENST00000419617STK3chr899718695-ENST00000395138SULT1A3chr1630214011+1731825451340431
ENST00000419617STK3chr899718695-ENST00000563322SULT1A3chr1630214011+1359825451358437

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000419617ENST00000354723STK3chr899718695-SULT1A3chr1630214011+0.0012322590.99876773
ENST00000419617ENST00000355544STK3chr899718695-SULT1A3chr1630214011+0.0012455220.9987545
ENST00000419617ENST00000395137STK3chr899718695-SULT1A3chr1630214011+0.0015260590.99847394
ENST00000419617ENST00000338971STK3chr899718695-SULT1A3chr1630214011+0.001511770.9984882
ENST00000419617ENST00000395138STK3chr899718695-SULT1A3chr1630214011+0.0011971230.9988029
ENST00000419617ENST00000563322STK3chr899718695-SULT1A3chr1630214011+0.0015733430.9984267

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Fusion Genomic Features for STK3-SULT1A3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
STK3chr899718694-SULT1A3chr1630214010+1.64E-091
STK3chr899718694-SULT1A3chr1630214010+1.64E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for STK3-SULT1A3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:99718695/chr16:30214011)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTK3chr8:99718695chr16:30214011ENST00000419617-61133_41228492.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTK3chr8:99718695chr16:30214011ENST00000419617-611287_328228492.0Coiled coilOntology_term=ECO:0000255
HgeneSTK3chr8:99718695chr16:30214011ENST00000419617-611442_475228492.0Coiled coilOntology_term=ECO:0000255
HgeneSTK3chr8:99718695chr16:30214011ENST00000419617-611308_314228492.0Compositional biasNote=Poly-Glu
HgeneSTK3chr8:99718695chr16:30214011ENST00000419617-611370_375228492.0Compositional biasNote=Poly-Glu
HgeneSTK3chr8:99718695chr16:30214011ENST00000419617-61127_278228492.0DomainProtein kinase
HgeneSTK3chr8:99718695chr16:30214011ENST00000419617-611437_484228492.0DomainSARAH


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Fusion Gene Sequence for STK3-SULT1A3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>87589_87589_1_STK3-SULT1A3_STK3_chr8_99718695_ENST00000419617_SULT1A3_chr16_30214011_ENST00000338971_length(transcript)=1449nt_BP=825nt
CCGCGGAGTTACGGGAAAGTTGGTCCGAGTTCCCAGAGTTTCCCTCTGTGGTGCCCTAGGCTCGGCCGGCCGGTGCCCCGGCTCCTTTCC
TCCTTTCGGCCTTCGCCGTCCACCAGGTCCCTCTCTCTGTCCCCGGCCGCCATGGAGCAGCCGCCGGCGCCTAAGAGTAAACTAAAAAAG
CTGAGTGAAGACAGTTTGACTAAGCAGCCTGAAGAAGTTTTTGATGTATTAGAGAAGCTTGGAGAAGGGTCTTATGGAAGTGTATTTAAA
GCAATACACAAGGAATCCGGTCAAGTTGTCGCAATTAAACAAGTACCTGTTGAATCAGATCTTCAGGAAATAATCAAAGAAATTTCCATA
ATGCAGCAATGTGACAGCCCATATGTTGTAAAGTACTATGGCAGTTATTTTAAGAATACAGACCTCTGGATTGTTATGGAGTACTGTGGC
GCTGGCTCTGTCTCAGACATAATTAGATTACGAAACAAGACATTAATAGAAGATGAAATTGCAACCATTCTTAAATCTACATTGAAAGGA
CTAGAATATTTGCACTTTATGAGAAAAATACACAGAGATATAAAAGCTGGAAATATTCTCCTCAATACAGAAGGACATGCAAAATTGGCA
GATTTTGGAGTGGCTGGTCAGTTAACAGATACAATGGCAAAACGCAATACTGTAATAGGAACTCCATTTTGGATGGCTCCTGAGGTGATT
CAAGAAATAGGCTATAACTGTGTGGCCGACATCTGGTCCCTTGGCATTACTTCTATAGAAATGGCTGAAGGAAAACCTCCTTATGCTGAT
ATACATCCAATGAGGGTGGTCTATGTTGCCCGAAACCCAAAGGACGTGGCGGTCTCCTACTACCATTTCCACCGTATGGAAAAGGCGCAC
CCTGAGCCTGGGACCTGGGACAGCTTCCTGGAAAAGTTCATGGCTGGAGAAGTGTCCTACGGGTCCTGGTACCAGCACGTGCAGGAGTGG
TGGGAGCTGAGCCGCACCCACCCTGTTCTCTACCTCTTCTATGAAGACATGAAGGAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAG
TTTGTGGGGCGCTCCCTGCCAGAGGAGACCATGGACTTCATGGTTCAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAAC
TACACCACCGTCCCCCAGGAGCTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACC
GTGGCGCAGAATGAGCGCTTCGATGCGGACTATGCGGAGAAGATGGCAGGCTGCAGCCTCAGCTTCCGCTCTGAGCTGTGAGAGGGGCTC
CTGGAGTCACTGCAGAGGGAGTGTGCGAATCTACCCTGACCAATGGGCTCAAGAATAAAGTATGATTTTTGAGTCAGGCACAGTGGCTCA

>87589_87589_1_STK3-SULT1A3_STK3_chr8_99718695_ENST00000419617_SULT1A3_chr16_30214011_ENST00000338971_length(amino acids)=431AA_BP=176
MWCPRLGRPVPRLLSSFRPSPSTRSLSLSPAAMEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV
PVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIK
AGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRVVYVARNPKD
VAVSYYHFHRMEKAHPEPGTWDSFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETMDFMV

--------------------------------------------------------------
>87589_87589_2_STK3-SULT1A3_STK3_chr8_99718695_ENST00000419617_SULT1A3_chr16_30214011_ENST00000354723_length(transcript)=1727nt_BP=825nt
CCGCGGAGTTACGGGAAAGTTGGTCCGAGTTCCCAGAGTTTCCCTCTGTGGTGCCCTAGGCTCGGCCGGCCGGTGCCCCGGCTCCTTTCC
TCCTTTCGGCCTTCGCCGTCCACCAGGTCCCTCTCTCTGTCCCCGGCCGCCATGGAGCAGCCGCCGGCGCCTAAGAGTAAACTAAAAAAG
CTGAGTGAAGACAGTTTGACTAAGCAGCCTGAAGAAGTTTTTGATGTATTAGAGAAGCTTGGAGAAGGGTCTTATGGAAGTGTATTTAAA
GCAATACACAAGGAATCCGGTCAAGTTGTCGCAATTAAACAAGTACCTGTTGAATCAGATCTTCAGGAAATAATCAAAGAAATTTCCATA
ATGCAGCAATGTGACAGCCCATATGTTGTAAAGTACTATGGCAGTTATTTTAAGAATACAGACCTCTGGATTGTTATGGAGTACTGTGGC
GCTGGCTCTGTCTCAGACATAATTAGATTACGAAACAAGACATTAATAGAAGATGAAATTGCAACCATTCTTAAATCTACATTGAAAGGA
CTAGAATATTTGCACTTTATGAGAAAAATACACAGAGATATAAAAGCTGGAAATATTCTCCTCAATACAGAAGGACATGCAAAATTGGCA
GATTTTGGAGTGGCTGGTCAGTTAACAGATACAATGGCAAAACGCAATACTGTAATAGGAACTCCATTTTGGATGGCTCCTGAGGTGATT
CAAGAAATAGGCTATAACTGTGTGGCCGACATCTGGTCCCTTGGCATTACTTCTATAGAAATGGCTGAAGGAAAACCTCCTTATGCTGAT
ATACATCCAATGAGGGTGGTCTATGTTGCCCGAAACCCAAAGGACGTGGCGGTCTCCTACTACCATTTCCACCGTATGGAAAAGGCGCAC
CCTGAGCCTGGGACCTGGGACAGCTTCCTGGAAAAGTTCATGGCTGGAGAAGTGTCCTACGGGTCCTGGTACCAGCACGTGCAGGAGTGG
TGGGAGCTGAGCCGCACCCACCCTGTTCTCTACCTCTTCTATGAAGACATGAAGGAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAG
TTTGTGGGGCGCTCCCTGCCAGAGGAGACCATGGACTTCATGGTTCAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAAC
TACACCACCGTCCCCCAGGAGCTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACC
GTGGCGCAGAATGAGCGCTTCGATGCGGACTATGCGGAGAAGATGGCAGGCTGCAGCCTCAGCTTCCGCTCTGAGCTGTGAGAGGGGCTC
CTGGAGTCACTGCAGAGGGAGTGTGCGAATCTACCCTGACCAATGGGCTCAAGAATAAAGTATGATTTTTGAGTCAGGCACAGTGGCTCA
TGTCTGCAATCCCAGCGATTTGGGAGGTTGAGCTGGTAGGATCACAATAGGCCACGAATTTGAGACCAGCCTGGTAAAATAGTGAGACCT
CATCTCTACAAAGATGTAAAAAAATTAGCCACATGTGCTGGCACTTACCTGTAGTCCCAGCTACTTGGGAAGCAGAGGCTGGAGGATCAT
TTCAGCCCAGGAGGTTGTGGATACAGTGAGTTATGACATGCCCATTCACTACAGCCTGGATGACAAGCAAGACCCTCCCTCCAAAGAAAA

>87589_87589_2_STK3-SULT1A3_STK3_chr8_99718695_ENST00000419617_SULT1A3_chr16_30214011_ENST00000354723_length(amino acids)=431AA_BP=176
MWCPRLGRPVPRLLSSFRPSPSTRSLSLSPAAMEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV
PVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIK
AGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRVVYVARNPKD
VAVSYYHFHRMEKAHPEPGTWDSFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETMDFMV

--------------------------------------------------------------
>87589_87589_3_STK3-SULT1A3_STK3_chr8_99718695_ENST00000419617_SULT1A3_chr16_30214011_ENST00000355544_length(transcript)=1722nt_BP=825nt
CCGCGGAGTTACGGGAAAGTTGGTCCGAGTTCCCAGAGTTTCCCTCTGTGGTGCCCTAGGCTCGGCCGGCCGGTGCCCCGGCTCCTTTCC
TCCTTTCGGCCTTCGCCGTCCACCAGGTCCCTCTCTCTGTCCCCGGCCGCCATGGAGCAGCCGCCGGCGCCTAAGAGTAAACTAAAAAAG
CTGAGTGAAGACAGTTTGACTAAGCAGCCTGAAGAAGTTTTTGATGTATTAGAGAAGCTTGGAGAAGGGTCTTATGGAAGTGTATTTAAA
GCAATACACAAGGAATCCGGTCAAGTTGTCGCAATTAAACAAGTACCTGTTGAATCAGATCTTCAGGAAATAATCAAAGAAATTTCCATA
ATGCAGCAATGTGACAGCCCATATGTTGTAAAGTACTATGGCAGTTATTTTAAGAATACAGACCTCTGGATTGTTATGGAGTACTGTGGC
GCTGGCTCTGTCTCAGACATAATTAGATTACGAAACAAGACATTAATAGAAGATGAAATTGCAACCATTCTTAAATCTACATTGAAAGGA
CTAGAATATTTGCACTTTATGAGAAAAATACACAGAGATATAAAAGCTGGAAATATTCTCCTCAATACAGAAGGACATGCAAAATTGGCA
GATTTTGGAGTGGCTGGTCAGTTAACAGATACAATGGCAAAACGCAATACTGTAATAGGAACTCCATTTTGGATGGCTCCTGAGGTGATT
CAAGAAATAGGCTATAACTGTGTGGCCGACATCTGGTCCCTTGGCATTACTTCTATAGAAATGGCTGAAGGAAAACCTCCTTATGCTGAT
ATACATCCAATGAGGGTGGTCTATGTTGCCCGAAACCCAAAGGACGTGGCGGTCTCCTACTACCATTTCCACCGTATGGAAAAGGCGCAC
CCTGAGCCTGGGACCTGGGACAGCTTCCTGGAAAAGTTCATGGCTGGAGAAGTGTCCTACGGGTCCTGGTACCAGCACGTGCAGGAGTGG
TGGGAGCTGAGCCGCACCCACCCTGTTCTCTACCTCTTCTATGAAGACATGAAGGAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAG
TTTGTGGGGCGCTCCCTGCCAGAGGAGACCATGGACTTCATGGTTCAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAAC
TACACCACCGTCCCCCAGGAGCTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACC
GTGGCGCAGAATGAGCGCTTCGATGCGGACTATGCGGAGAAGATGGCAGGCTGCAGCCTCAGCTTCCGCTCTGAGCTGTGAGAGGGGCTC
CTGGAGTCACTGCAGAGGGAGTGTGCGAATCTACCCTGACCAATGGGCTCAAGAATAAAGTATGATTTTTGAGTCAGGCACAGTGGCTCA
TGTCTGCAATCCCAGCGATTTGGGAGGTTGAGCTGGTAGGATCACAATAGGCCACGAATTTGAGACCAGCCTGGTAAAATAGTGAGACCT
CATCTCTACAAAGATGTAAAAAAATTAGCCACATGTGCTGGCACTTACCTGTAGTCCCAGCTACTTGGGAAGCAGAGGCTGGAGGATCAT
TTCAGCCCAGGAGGTTGTGGATACAGTGAGTTATGACATGCCCATTCACTACAGCCTGGATGACAAGCAAGACCCTCCCTCCAAAGAAAA

>87589_87589_3_STK3-SULT1A3_STK3_chr8_99718695_ENST00000419617_SULT1A3_chr16_30214011_ENST00000355544_length(amino acids)=431AA_BP=176
MWCPRLGRPVPRLLSSFRPSPSTRSLSLSPAAMEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV
PVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIK
AGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRVVYVARNPKD
VAVSYYHFHRMEKAHPEPGTWDSFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETMDFMV

--------------------------------------------------------------
>87589_87589_4_STK3-SULT1A3_STK3_chr8_99718695_ENST00000419617_SULT1A3_chr16_30214011_ENST00000395137_length(transcript)=1429nt_BP=825nt
CCGCGGAGTTACGGGAAAGTTGGTCCGAGTTCCCAGAGTTTCCCTCTGTGGTGCCCTAGGCTCGGCCGGCCGGTGCCCCGGCTCCTTTCC
TCCTTTCGGCCTTCGCCGTCCACCAGGTCCCTCTCTCTGTCCCCGGCCGCCATGGAGCAGCCGCCGGCGCCTAAGAGTAAACTAAAAAAG
CTGAGTGAAGACAGTTTGACTAAGCAGCCTGAAGAAGTTTTTGATGTATTAGAGAAGCTTGGAGAAGGGTCTTATGGAAGTGTATTTAAA
GCAATACACAAGGAATCCGGTCAAGTTGTCGCAATTAAACAAGTACCTGTTGAATCAGATCTTCAGGAAATAATCAAAGAAATTTCCATA
ATGCAGCAATGTGACAGCCCATATGTTGTAAAGTACTATGGCAGTTATTTTAAGAATACAGACCTCTGGATTGTTATGGAGTACTGTGGC
GCTGGCTCTGTCTCAGACATAATTAGATTACGAAACAAGACATTAATAGAAGATGAAATTGCAACCATTCTTAAATCTACATTGAAAGGA
CTAGAATATTTGCACTTTATGAGAAAAATACACAGAGATATAAAAGCTGGAAATATTCTCCTCAATACAGAAGGACATGCAAAATTGGCA
GATTTTGGAGTGGCTGGTCAGTTAACAGATACAATGGCAAAACGCAATACTGTAATAGGAACTCCATTTTGGATGGCTCCTGAGGTGATT
CAAGAAATAGGCTATAACTGTGTGGCCGACATCTGGTCCCTTGGCATTACTTCTATAGAAATGGCTGAAGGAAAACCTCCTTATGCTGAT
ATACATCCAATGAGGGTGGTCTATGTTGCCCGAAACCCAAAGGACGTGGCGGTCTCCTACTACCATTTCCACCGTATGGAAAAGGCGCAC
CCTGAGCCTGGGACCTGGGACAGCTTCCTGGAAAAGTTCATGGCTGGAGAAGTGTCCTACGGGTCCTGGTACCAGCACGTGCAGGAGTGG
TGGGAGCTGAGCCGCACCCACCCTGTTCTCTACCTCTTCTATGAAGACATGAAGGAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAG
TTTGTGGGGCGCTCCCTGCCAGAGGAGACCATGGACTTCATGGTTCAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAAC
TACACCACCGTCCCCCAGGAGCTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACC
GTGGCGCAGAATGAGCGCTTCGATGCGGACTATGCGGAGAAGATGGCAGGCTGCAGCCTCAGCTTCCGCTCTGAGCTGTGAGAGGGGCTC

>87589_87589_4_STK3-SULT1A3_STK3_chr8_99718695_ENST00000419617_SULT1A3_chr16_30214011_ENST00000395137_length(amino acids)=431AA_BP=176
MWCPRLGRPVPRLLSSFRPSPSTRSLSLSPAAMEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV
PVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIK
AGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRVVYVARNPKD
VAVSYYHFHRMEKAHPEPGTWDSFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETMDFMV

--------------------------------------------------------------
>87589_87589_5_STK3-SULT1A3_STK3_chr8_99718695_ENST00000419617_SULT1A3_chr16_30214011_ENST00000395138_length(transcript)=1731nt_BP=825nt
CCGCGGAGTTACGGGAAAGTTGGTCCGAGTTCCCAGAGTTTCCCTCTGTGGTGCCCTAGGCTCGGCCGGCCGGTGCCCCGGCTCCTTTCC
TCCTTTCGGCCTTCGCCGTCCACCAGGTCCCTCTCTCTGTCCCCGGCCGCCATGGAGCAGCCGCCGGCGCCTAAGAGTAAACTAAAAAAG
CTGAGTGAAGACAGTTTGACTAAGCAGCCTGAAGAAGTTTTTGATGTATTAGAGAAGCTTGGAGAAGGGTCTTATGGAAGTGTATTTAAA
GCAATACACAAGGAATCCGGTCAAGTTGTCGCAATTAAACAAGTACCTGTTGAATCAGATCTTCAGGAAATAATCAAAGAAATTTCCATA
ATGCAGCAATGTGACAGCCCATATGTTGTAAAGTACTATGGCAGTTATTTTAAGAATACAGACCTCTGGATTGTTATGGAGTACTGTGGC
GCTGGCTCTGTCTCAGACATAATTAGATTACGAAACAAGACATTAATAGAAGATGAAATTGCAACCATTCTTAAATCTACATTGAAAGGA
CTAGAATATTTGCACTTTATGAGAAAAATACACAGAGATATAAAAGCTGGAAATATTCTCCTCAATACAGAAGGACATGCAAAATTGGCA
GATTTTGGAGTGGCTGGTCAGTTAACAGATACAATGGCAAAACGCAATACTGTAATAGGAACTCCATTTTGGATGGCTCCTGAGGTGATT
CAAGAAATAGGCTATAACTGTGTGGCCGACATCTGGTCCCTTGGCATTACTTCTATAGAAATGGCTGAAGGAAAACCTCCTTATGCTGAT
ATACATCCAATGAGGGTGGTCTATGTTGCCCGAAACCCAAAGGACGTGGCGGTCTCCTACTACCATTTCCACCGTATGGAAAAGGCGCAC
CCTGAGCCTGGGACCTGGGACAGCTTCCTGGAAAAGTTCATGGCTGGAGAAGTGTCCTACGGGTCCTGGTACCAGCACGTGCAGGAGTGG
TGGGAGCTGAGCCGCACCCACCCTGTTCTCTACCTCTTCTATGAAGACATGAAGGAGAACCCCAAAAGGGAGATTCAAAAGATCCTGGAG
TTTGTGGGGCGCTCCCTGCCAGAGGAGACCATGGACTTCATGGTTCAGCACACGTCGTTCAAGGAGATGAAGAAGAACCCTATGACCAAC
TACACCACCGTCCCCCAGGAGCTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATGGCTGGGGACTGGAAGACCACCTTCACC
GTGGCGCAGAATGAGCGCTTCGATGCGGACTATGCGGAGAAGATGGCAGGCTGCAGCCTCAGCTTCCGCTCTGAGCTGTGAGAGGGGCTC
CTGGAGTCACTGCAGAGGGAGTGTGCGAATCTACCCTGACCAATGGGCTCAAGAATAAAGTATGATTTTTGAGTCAGGCACAGTGGCTCA
TGTCTGCAATCCCAGCGATTTGGGAGGTTGAGCTGGTAGGATCACAATAGGCCACGAATTTGAGACCAGCCTGGTAAAATAGTGAGACCT
CATCTCTACAAAGATGTAAAAAAATTAGCCACATGTGCTGGCACTTACCTGTAGTCCCAGCTACTTGGGAAGCAGAGGCTGGAGGATCAT
TTCAGCCCAGGAGGTTGTGGATACAGTGAGTTATGACATGCCCATTCACTACAGCCTGGATGACAAGCAAGACCCTCCCTCCAAAGAAAA

>87589_87589_5_STK3-SULT1A3_STK3_chr8_99718695_ENST00000419617_SULT1A3_chr16_30214011_ENST00000395138_length(amino acids)=431AA_BP=176
MWCPRLGRPVPRLLSSFRPSPSTRSLSLSPAAMEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV
PVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIK
AGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRVVYVARNPKD
VAVSYYHFHRMEKAHPEPGTWDSFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETMDFMV

--------------------------------------------------------------
>87589_87589_6_STK3-SULT1A3_STK3_chr8_99718695_ENST00000419617_SULT1A3_chr16_30214011_ENST00000563322_length(transcript)=1359nt_BP=825nt
CCGCGGAGTTACGGGAAAGTTGGTCCGAGTTCCCAGAGTTTCCCTCTGTGGTGCCCTAGGCTCGGCCGGCCGGTGCCCCGGCTCCTTTCC
TCCTTTCGGCCTTCGCCGTCCACCAGGTCCCTCTCTCTGTCCCCGGCCGCCATGGAGCAGCCGCCGGCGCCTAAGAGTAAACTAAAAAAG
CTGAGTGAAGACAGTTTGACTAAGCAGCCTGAAGAAGTTTTTGATGTATTAGAGAAGCTTGGAGAAGGGTCTTATGGAAGTGTATTTAAA
GCAATACACAAGGAATCCGGTCAAGTTGTCGCAATTAAACAAGTACCTGTTGAATCAGATCTTCAGGAAATAATCAAAGAAATTTCCATA
ATGCAGCAATGTGACAGCCCATATGTTGTAAAGTACTATGGCAGTTATTTTAAGAATACAGACCTCTGGATTGTTATGGAGTACTGTGGC
GCTGGCTCTGTCTCAGACATAATTAGATTACGAAACAAGACATTAATAGAAGATGAAATTGCAACCATTCTTAAATCTACATTGAAAGGA
CTAGAATATTTGCACTTTATGAGAAAAATACACAGAGATATAAAAGCTGGAAATATTCTCCTCAATACAGAAGGACATGCAAAATTGGCA
GATTTTGGAGTGGCTGGTCAGTTAACAGATACAATGGCAAAACGCAATACTGTAATAGGAACTCCATTTTGGATGGCTCCTGAGGTGATT
CAAGAAATAGGCTATAACTGTGTGGCCGACATCTGGTCCCTTGGCATTACTTCTATAGAAATGGCTGAAGGAAAACCTCCTTATGCTGAT
ATACATCCAATGAGGGTGGTCTATGTTGCCCGAAACCCAAAGGACGTGGCGGTCTCCTACTACCATTTCCACCGTATGGAAAAGGCGCAC
CCTGAGCCTGGGACCTGGGACAGCTTCCTGGAAAAGTTCATGGCTGGAGAAGTGTCCTACGGGTCCTGGTACCAGCACGTGCAGGAGTGG
TGGGAGCTGAGCCGCACCCACCCTGTTCTCTACCTCTTCTATGAAGACATGAAGGAGGAGCCCTCTGCTGCTCAGAACCCCAAAAGGGAG
ATTCAAAAGATCCTGGAGTTTGTGGGGCGCTCCCTGCCAGAGGAGACCATGGACTTCATGGTTCAGCACACGTCGTTCAAGGAGATGAAG
AAGAACCCTATGACCAACTACACCACCGTCCCCCAGGAGCTCATGGACCACAGCATCTCCCCCTTCATGAGGAAAGGCATGGCTGGGGAC
TGGAAGACCACCTTCACCGTGGCGCAGAATGAGCGCTTCGATGCGGACTATGCGGAGAAGATGGCAGGCTGCAGCCTCAGCTTCCGCTCT

>87589_87589_6_STK3-SULT1A3_STK3_chr8_99718695_ENST00000419617_SULT1A3_chr16_30214011_ENST00000563322_length(amino acids)=437AA_BP=176
MWCPRLGRPVPRLLSSFRPSPSTRSLSLSPAAMEQPPAPKSKLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAIKQV
PVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLHFMRKIHRDIK
AGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGKPPYADIHPMRVVYVARNPKD
VAVSYYHFHRMEKAHPEPGTWDSFLEKFMAGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKEEPSAAQNPKREIQKILEFVGRSLPEE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for STK3-SULT1A3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for STK3-SULT1A3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for STK3-SULT1A3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource