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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:STK4-WISP2 (FusionGDB2 ID:87606) |
Fusion Gene Summary for STK4-WISP2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: STK4-WISP2 | Fusion gene ID: 87606 | Hgene | Tgene | Gene symbol | STK4 | WISP2 | Gene ID | 6789 | 8839 |
| Gene name | serine/threonine kinase 4 | cellular communication network factor 5 | |
| Synonyms | KRS2|MST1|YSK3 | CT58|CTGF-L|WISP2 | |
| Cytomap | 20q13.12 | 20q13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase 4STE20-like kinase MST1kinase responsive to stress 2mammalian STE20-like protein kinase 1mammalian sterile 20-like 1serine/threonine-protein kinase Krs-2 | WNT1-inducible-signaling pathway protein 2CCN family member 5WNT1 inducible signaling pathway protein 2connective tissue growth factor-like proteinconnective tissue growth factor-related protein 58 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q13043 | . | |
| Ensembl transtripts involved in fusion gene | ENST00000372801, ENST00000372806, ENST00000396731, ENST00000499879, ENST00000487587, | ENST00000471629, ENST00000190983, ENST00000372865, ENST00000372868, | |
| Fusion gene scores | * DoF score | 9 X 6 X 7=378 | 3 X 3 X 3=27 |
| # samples | 9 | 3 | |
| ** MAII score | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: STK4 [Title/Abstract] AND WISP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | STK4(43629994)-WISP2(43353379), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | STK4 | GO:0000902 | cell morphogenesis | 11805089 |
| Hgene | STK4 | GO:0001934 | positive regulation of protein phosphorylation | 19962960 |
| Hgene | STK4 | GO:0006468 | protein phosphorylation | 8566796|11805089 |
| Hgene | STK4 | GO:0006915 | apoptotic process | 21212262 |
| Hgene | STK4 | GO:0018105 | peptidyl-serine phosphorylation | 16751106 |
| Hgene | STK4 | GO:0032092 | positive regulation of protein binding | 22292086 |
| Hgene | STK4 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 19962960 |
| Hgene | STK4 | GO:0035329 | hippo signaling | 20412773 |
| Hgene | STK4 | GO:0035556 | intracellular signal transduction | 8566796 |
| Hgene | STK4 | GO:0043065 | positive regulation of apoptotic process | 15109305 |
| Hgene | STK4 | GO:0046777 | protein autophosphorylation | 11805089 |
| Hgene | STK4 | GO:0050821 | protein stabilization | 19962960 |
| Fusion gene breakpoints across STK4 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across WISP2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | GBM | TCGA-06-5856-01A | STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353379 | + |
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Fusion Gene ORF analysis for STK4-WISP2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000372801 | ENST00000471629 | STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353379 | + |
| 5CDS-3UTR | ENST00000372806 | ENST00000471629 | STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353379 | + |
| 5CDS-3UTR | ENST00000396731 | ENST00000471629 | STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353379 | + |
| 5CDS-3UTR | ENST00000499879 | ENST00000471629 | STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353379 | + |
| 5CDS-intron | ENST00000372801 | ENST00000190983 | STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353379 | + |
| 5CDS-intron | ENST00000372801 | ENST00000372865 | STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353379 | + |
| 5CDS-intron | ENST00000372806 | ENST00000190983 | STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353379 | + |
| 5CDS-intron | ENST00000372806 | ENST00000372865 | STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353379 | + |
| 5CDS-intron | ENST00000396731 | ENST00000190983 | STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353379 | + |
| 5CDS-intron | ENST00000396731 | ENST00000372865 | STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353379 | + |
| 5CDS-intron | ENST00000499879 | ENST00000190983 | STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353379 | + |
| 5CDS-intron | ENST00000499879 | ENST00000372865 | STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353379 | + |
| In-frame | ENST00000372801 | ENST00000372868 | STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353379 | + |
| In-frame | ENST00000372806 | ENST00000372868 | STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353379 | + |
| In-frame | ENST00000396731 | ENST00000372868 | STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353379 | + |
| In-frame | ENST00000499879 | ENST00000372868 | STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353379 | + |
| intron-3CDS | ENST00000487587 | ENST00000372868 | STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353379 | + |
| intron-3UTR | ENST00000487587 | ENST00000471629 | STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353379 | + |
| intron-intron | ENST00000487587 | ENST00000190983 | STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353379 | + |
| intron-intron | ENST00000487587 | ENST00000372865 | STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353379 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000372806 | STK4 | chr20 | 43629994 | + | ENST00000372868 | WISP2 | chr20 | 43353379 | + | 2222 | 1242 | 23 | 1717 | 564 |
| ENST00000396731 | STK4 | chr20 | 43629994 | + | ENST00000372868 | WISP2 | chr20 | 43353379 | + | 2195 | 1215 | 68 | 1690 | 540 |
| ENST00000372801 | STK4 | chr20 | 43629994 | + | ENST00000372868 | WISP2 | chr20 | 43353379 | + | 2174 | 1194 | 47 | 1669 | 540 |
| ENST00000499879 | STK4 | chr20 | 43629994 | + | ENST00000372868 | WISP2 | chr20 | 43353379 | + | 2005 | 1025 | 43 | 1500 | 485 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000372806 | ENST00000372868 | STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353379 | + | 0.0035281 | 0.9964719 |
| ENST00000396731 | ENST00000372868 | STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353379 | + | 0.003794849 | 0.99620515 |
| ENST00000372801 | ENST00000372868 | STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353379 | + | 0.003682658 | 0.99631727 |
| ENST00000499879 | ENST00000372868 | STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353379 | + | 0.00536524 | 0.99463475 |
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Fusion Genomic Features for STK4-WISP2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353378 | + | 5.17E-10 | 1 |
| STK4 | chr20 | 43629994 | + | WISP2 | chr20 | 43353378 | + | 5.17E-10 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for STK4-WISP2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:43629994/chr20:43353379) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| STK4 | . |
| FUNCTION: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation (By similarity). Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis. Phosphorylates FOXO3 upon oxidative stress, which results in its nuclear translocation and cell death initiation. Phosphorylates MOBKL1A, MOBKL1B and RASSF2. Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T). Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner. Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage. Acts as an inhibitor of PKB/AKT1. Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes. {ECO:0000250|UniProtKB:Q9JI11, ECO:0000269|PubMed:11278283, ECO:0000269|PubMed:11517310, ECO:0000269|PubMed:12757711, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:16751106, ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:17932490, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18986304, ECO:0000269|PubMed:19525978, ECO:0000269|PubMed:21212262, ECO:0000269|PubMed:21245099, ECO:0000269|PubMed:21512132, ECO:0000269|PubMed:8702870, ECO:0000269|PubMed:8816758}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | STK4 | chr20:43629994 | chr20:43353379 | ENST00000372801 | + | 9 | 12 | 290_310 | 382 | 632.6666666666666 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | STK4 | chr20:43629994 | chr20:43353379 | ENST00000372806 | + | 9 | 11 | 290_310 | 382 | 488.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | STK4 | chr20:43629994 | chr20:43353379 | ENST00000396731 | + | 9 | 11 | 290_310 | 382 | 463.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | STK4 | chr20:43629994 | chr20:43353379 | ENST00000372801 | + | 9 | 12 | 373_378 | 382 | 632.6666666666666 | Compositional bias | Note=Poly-Glu |
| Hgene | STK4 | chr20:43629994 | chr20:43353379 | ENST00000372806 | + | 9 | 11 | 373_378 | 382 | 488.0 | Compositional bias | Note=Poly-Glu |
| Hgene | STK4 | chr20:43629994 | chr20:43353379 | ENST00000396731 | + | 9 | 11 | 373_378 | 382 | 463.0 | Compositional bias | Note=Poly-Glu |
| Hgene | STK4 | chr20:43629994 | chr20:43353379 | ENST00000372801 | + | 9 | 12 | 30_281 | 382 | 632.6666666666666 | Domain | Protein kinase |
| Hgene | STK4 | chr20:43629994 | chr20:43353379 | ENST00000372806 | + | 9 | 11 | 30_281 | 382 | 488.0 | Domain | Protein kinase |
| Hgene | STK4 | chr20:43629994 | chr20:43353379 | ENST00000396731 | + | 9 | 11 | 30_281 | 382 | 463.0 | Domain | Protein kinase |
| Hgene | STK4 | chr20:43629994 | chr20:43353379 | ENST00000372801 | + | 9 | 12 | 36_44 | 382 | 632.6666666666666 | Nucleotide binding | ATP |
| Hgene | STK4 | chr20:43629994 | chr20:43353379 | ENST00000372806 | + | 9 | 11 | 36_44 | 382 | 488.0 | Nucleotide binding | ATP |
| Hgene | STK4 | chr20:43629994 | chr20:43353379 | ENST00000396731 | + | 9 | 11 | 36_44 | 382 | 463.0 | Nucleotide binding | ATP |
| Tgene | WISP2 | chr20:43629994 | chr20:43353379 | ENST00000190983 | 1 | 4 | 194_238 | 92 | 251.0 | Domain | TSP type-1 | |
| Tgene | WISP2 | chr20:43629994 | chr20:43353379 | ENST00000190983 | 1 | 4 | 98_164 | 92 | 251.0 | Domain | VWFC | |
| Tgene | WISP2 | chr20:43629994 | chr20:43353379 | ENST00000372868 | 2 | 5 | 194_238 | 92 | 251.0 | Domain | TSP type-1 | |
| Tgene | WISP2 | chr20:43629994 | chr20:43353379 | ENST00000372868 | 2 | 5 | 98_164 | 92 | 251.0 | Domain | VWFC |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | STK4 | chr20:43629994 | chr20:43353379 | ENST00000372801 | + | 9 | 12 | 433_480 | 382 | 632.6666666666666 | Domain | SARAH |
| Hgene | STK4 | chr20:43629994 | chr20:43353379 | ENST00000372806 | + | 9 | 11 | 433_480 | 382 | 488.0 | Domain | SARAH |
| Hgene | STK4 | chr20:43629994 | chr20:43353379 | ENST00000396731 | + | 9 | 11 | 433_480 | 382 | 463.0 | Domain | SARAH |
| Tgene | WISP2 | chr20:43629994 | chr20:43353379 | ENST00000190983 | 1 | 4 | 24_94 | 92 | 251.0 | Domain | IGFBP N-terminal | |
| Tgene | WISP2 | chr20:43629994 | chr20:43353379 | ENST00000372868 | 2 | 5 | 24_94 | 92 | 251.0 | Domain | IGFBP N-terminal |
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Fusion Gene Sequence for STK4-WISP2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >87606_87606_1_STK4-WISP2_STK4_chr20_43629994_ENST00000372801_WISP2_chr20_43353379_ENST00000372868_length(transcript)=2174nt_BP=1194nt CGGGAGGATGGAGCAGTGAGCGGGTCTGGGCGGCTGCTGGCAGCGCCATGGAGACGGTACAGCTGAGGAACCCGCCGCGCCGGCAGCTGA AAAAGTTGGATGAAGATAGTTTAACCAAACAACCAGAAGAAGTATTTGATGTCTTAGAGAAACTTGGAGAAGGGTCCTATGGCAGCGTAT ACAAAGCTATTCATAAAGAGACCGGCCAGATTGTTGCTATTAAGCAAGTTCCTGTGGAATCAGACCTCCAGGAGATAATCAAAGAAATCT CTATAATGCAGCAATGTGACAGCCCTCATGTAGTCAAATATTATGGCAGTTATTTTAAGAACACAGACTTATGGATCGTTATGGAGTACT GTGGGGCTGGTTCTGTATCTGATATCATTCGATTACGAAATAAAACGTTAACAGAAGATGAAATAGCTACAATATTACAATCAACTCTTA AGGGACTTGAATACCTTCATTTTATGAGAAAAATACACCGAGATATCAAGGCAGGAAATATTTTGCTAAATACAGAAGGACATGCAAAAC TTGCAGATTTTGGGGTAGCAGGTCAACTTACAGATACCATGGCCAAGCGGAATACAGTGATAGGAACACCATTTTGGATGGCTCCAGAAG TGATTCAGGAAATTGGATACAACTGTGTAGCAGACATCTGGTCCCTGGGAATAACTGCCATAGAAATGGCTGAAGGAAAGCCCCCTTATG CTGATATCCATCCAATGAGGGCAATCTTCATGATTCCTACAAATCCTCCTCCCACATTCCGAAAACCAGAGCTATGGTCAGATAACTTTA CAGATTTTGTGAAACAGTGTCTTGTAAAGAGCCCTGAGCAGAGGGCCACAGCCACTCAGCTCCTGCAGCACCCATTTGTCAGGAGTGCCA AAGGAGTGTCAATACTGCGAGACTTAATTAATGAAGCCATGGATGTGAAACTGAAACGCCAGGAATCCCAGCAGCGGGAAGTGGACCAGG ACGATGAAGAAAACTCAGAAGAGGATGAAATGGATTCTGGCACGATGGTTCGAGCAGTGGGTGATGAGATGGGCACTGTCCGAGTAGCCA GCACCATGACTGATGGAGCCAATACTATGATTGAGCACGATGACACGTTGCCATCACAACTGGGCACCATGGTGATCAATGCAGAGGATG AGGAAGAGGAAGGAACTATGAAAATGGCAGAGGACGACAGCAGCTGTGAGGTGAACGGCCGCCTGTATCGGGAAGGGGAGACCTTCCAGC CCCACTGCAGCATCCGCTGCCGCTGCGAGGACGGCGGCTTCACCTGCGTGCCGCTGTGCAGCGAGGATGTGCGGCTGCCCAGCTGGGACT GCCCCCACCCCAGGAGGGTCGAGGTCCTGGGCAAGTGCTGCCCTGAGTGGGTGTGCGGCCAAGGAGGGGGACTGGGGACCCAGCCCCTTC CAGCCCAAGGACCCCAGTTTTCTGGCCTTGTCTCTTCCCTGCCCCCTGGTGTCCCCTGCCCAGAATGGAGCACGGCCTGGGGACCCTGCT CGACCACCTGTGGGCTGGGCATGGCCACCCGGGTGTCCAACCAGAACCGCTTCTGCCGACTGGAGACCCAGCGCCGCCTGTGCCTGTCCA GGCCCTGCCCACCCTCCAGGGGTCGCAGTCCACAAAACAGTGCCTTCTAGAGCCGGGCTGGGAATGGGGACACGGTGTCCACCATCCCCA GCTGGTGGCCCTGTGCCTGGGCCCTGGGCTGATGGAAGATGGTCCGTGCCCAGGCCCTTGGCTGCAGGCAACACTTTAGCTTGGGTCCAC CATGCAGAACACCAATATTAACACGCTGCCTGGTCTGTCTGGATCCCGAGGTATGGCAGAGGTGCAAGACCTAGTCCCCTTTCCTCTAAC TCACTGCCTAGGAGGCTGGCCAAGGTGTCCAGGGTCCTCTAGCCCACTCCCTGCCTACACACACAGCCTATATCAAACATGCACACGGGC GAGCTTTCTCTCCGACTTCCCCTGGGCAAGAGATGGGACAAGCAGTCCCTTAATATTGAGGCTGCAGCAGGTGCTGGGCTGGACTGGCCA TTTTTCTGGGGGTAGGATGAAGAGAAGGCACACAGAGATTCTGGATCTCCTGCTGCCTTTTCTGGAGTTTGTAAAATTGTTCCTGAATAC >87606_87606_1_STK4-WISP2_STK4_chr20_43629994_ENST00000372801_WISP2_chr20_43353379_ENST00000372868_length(amino acids)=540AA_BP=383 METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYG SYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK RNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRA TATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDT LPSQLGTMVINAEDEEEEGTMKMAEDDSSCEVNGRLYREGETFQPHCSIRCRCEDGGFTCVPLCSEDVRLPSWDCPHPRRVEVLGKCCPE WVCGQGGGLGTQPLPAQGPQFSGLVSSLPPGVPCPEWSTAWGPCSTTCGLGMATRVSNQNRFCRLETQRRLCLSRPCPPSRGRSPQNSAF -------------------------------------------------------------- >87606_87606_2_STK4-WISP2_STK4_chr20_43629994_ENST00000372806_WISP2_chr20_43353379_ENST00000372868_length(transcript)=2222nt_BP=1242nt GGAAAGCGGAAGTGTGGGAGGGTCTGCGGGGCGGGCTCAGGAGGTCCGCGGGAGGATGGAGCAGTGAGCGGGTCTGGGCGGCTGCTGGCA GCGCCATGGAGACGGTACAGCTGAGGAACCCGCCGCGCCGGCAGCTGAAAAAGTTGGATGAAGATAGTTTAACCAAACAACCAGAAGAAG TATTTGATGTCTTAGAGAAACTTGGAGAAGGGTCCTATGGCAGCGTATACAAAGCTATTCATAAAGAGACCGGCCAGATTGTTGCTATTA AGCAAGTTCCTGTGGAATCAGACCTCCAGGAGATAATCAAAGAAATCTCTATAATGCAGCAATGTGACAGCCCTCATGTAGTCAAATATT ATGGCAGTTATTTTAAGAACACAGACTTATGGATCGTTATGGAGTACTGTGGGGCTGGTTCTGTATCTGATATCATTCGATTACGAAATA AAACGTTAACAGAAGATGAAATAGCTACAATATTACAATCAACTCTTAAGGGACTTGAATACCTTCATTTTATGAGAAAAATACACCGAG ATATCAAGGCAGGAAATATTTTGCTAAATACAGAAGGACATGCAAAACTTGCAGATTTTGGGGTAGCAGGTCAACTTACAGATACCATGG CCAAGCGGAATACAGTGATAGGAACACCATTTTGGATGGCTCCAGAAGTGATTCAGGAAATTGGATACAACTGTGTAGCAGACATCTGGT CCCTGGGAATAACTGCCATAGAAATGGCTGAAGGAAAGCCCCCTTATGCTGATATCCATCCAATGAGGGCAATCTTCATGATTCCTACAA ATCCTCCTCCCACATTCCGAAAACCAGAGCTATGGTCAGATAACTTTACAGATTTTGTGAAACAGTGTCTTGTAAAGAGCCCTGAGCAGA GGGCCACAGCCACTCAGCTCCTGCAGCACCCATTTGTCAGGAGTGCCAAAGGAGTGTCAATACTGCGAGACTTAATTAATGAAGCCATGG ATGTGAAACTGAAACGCCAGGAATCCCAGCAGCGGGAAGTGGACCAGGACGATGAAGAAAACTCAGAAGAGGATGAAATGGATTCTGGCA CGATGGTTCGAGCAGTGGGTGATGAGATGGGCACTGTCCGAGTAGCCAGCACCATGACTGATGGAGCCAATACTATGATTGAGCACGATG ACACGTTGCCATCACAACTGGGCACCATGGTGATCAATGCAGAGGATGAGGAAGAGGAAGGAACTATGAAAATGGCAGAGGACGACAGCA GCTGTGAGGTGAACGGCCGCCTGTATCGGGAAGGGGAGACCTTCCAGCCCCACTGCAGCATCCGCTGCCGCTGCGAGGACGGCGGCTTCA CCTGCGTGCCGCTGTGCAGCGAGGATGTGCGGCTGCCCAGCTGGGACTGCCCCCACCCCAGGAGGGTCGAGGTCCTGGGCAAGTGCTGCC CTGAGTGGGTGTGCGGCCAAGGAGGGGGACTGGGGACCCAGCCCCTTCCAGCCCAAGGACCCCAGTTTTCTGGCCTTGTCTCTTCCCTGC CCCCTGGTGTCCCCTGCCCAGAATGGAGCACGGCCTGGGGACCCTGCTCGACCACCTGTGGGCTGGGCATGGCCACCCGGGTGTCCAACC AGAACCGCTTCTGCCGACTGGAGACCCAGCGCCGCCTGTGCCTGTCCAGGCCCTGCCCACCCTCCAGGGGTCGCAGTCCACAAAACAGTG CCTTCTAGAGCCGGGCTGGGAATGGGGACACGGTGTCCACCATCCCCAGCTGGTGGCCCTGTGCCTGGGCCCTGGGCTGATGGAAGATGG TCCGTGCCCAGGCCCTTGGCTGCAGGCAACACTTTAGCTTGGGTCCACCATGCAGAACACCAATATTAACACGCTGCCTGGTCTGTCTGG ATCCCGAGGTATGGCAGAGGTGCAAGACCTAGTCCCCTTTCCTCTAACTCACTGCCTAGGAGGCTGGCCAAGGTGTCCAGGGTCCTCTAG CCCACTCCCTGCCTACACACACAGCCTATATCAAACATGCACACGGGCGAGCTTTCTCTCCGACTTCCCCTGGGCAAGAGATGGGACAAG CAGTCCCTTAATATTGAGGCTGCAGCAGGTGCTGGGCTGGACTGGCCATTTTTCTGGGGGTAGGATGAAGAGAAGGCACACAGAGATTCT >87606_87606_2_STK4-WISP2_STK4_chr20_43629994_ENST00000372806_WISP2_chr20_43353379_ENST00000372868_length(amino acids)=564AA_BP=407 MRGGLRRSAGGWSSERVWAAAGSAMETVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESD LQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNIL LNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRK PELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGD EMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKMAEDDSSCEVNGRLYREGETFQPHCSIRCRCEDGGFTCVPLCSE DVRLPSWDCPHPRRVEVLGKCCPEWVCGQGGGLGTQPLPAQGPQFSGLVSSLPPGVPCPEWSTAWGPCSTTCGLGMATRVSNQNRFCRLE -------------------------------------------------------------- >87606_87606_3_STK4-WISP2_STK4_chr20_43629994_ENST00000396731_WISP2_chr20_43353379_ENST00000372868_length(transcript)=2195nt_BP=1215nt GGGGCGGGCTCAGGAGGTCCGCGGGAGGATGGAGCAGTGAGCGGGTCTGGGCGGCTGCTGGCAGCGCCATGGAGACGGTACAGCTGAGGA ACCCGCCGCGCCGGCAGCTGAAAAAGTTGGATGAAGATAGTTTAACCAAACAACCAGAAGAAGTATTTGATGTCTTAGAGAAACTTGGAG AAGGGTCCTATGGCAGCGTATACAAAGCTATTCATAAAGAGACCGGCCAGATTGTTGCTATTAAGCAAGTTCCTGTGGAATCAGACCTCC AGGAGATAATCAAAGAAATCTCTATAATGCAGCAATGTGACAGCCCTCATGTAGTCAAATATTATGGCAGTTATTTTAAGAACACAGACT TATGGATCGTTATGGAGTACTGTGGGGCTGGTTCTGTATCTGATATCATTCGATTACGAAATAAAACGTTAACAGAAGATGAAATAGCTA CAATATTACAATCAACTCTTAAGGGACTTGAATACCTTCATTTTATGAGAAAAATACACCGAGATATCAAGGCAGGAAATATTTTGCTAA ATACAGAAGGACATGCAAAACTTGCAGATTTTGGGGTAGCAGGTCAACTTACAGATACCATGGCCAAGCGGAATACAGTGATAGGAACAC CATTTTGGATGGCTCCAGAAGTGATTCAGGAAATTGGATACAACTGTGTAGCAGACATCTGGTCCCTGGGAATAACTGCCATAGAAATGG CTGAAGGAAAGCCCCCTTATGCTGATATCCATCCAATGAGGGCAATCTTCATGATTCCTACAAATCCTCCTCCCACATTCCGAAAACCAG AGCTATGGTCAGATAACTTTACAGATTTTGTGAAACAGTGTCTTGTAAAGAGCCCTGAGCAGAGGGCCACAGCCACTCAGCTCCTGCAGC ACCCATTTGTCAGGAGTGCCAAAGGAGTGTCAATACTGCGAGACTTAATTAATGAAGCCATGGATGTGAAACTGAAACGCCAGGAATCCC AGCAGCGGGAAGTGGACCAGGACGATGAAGAAAACTCAGAAGAGGATGAAATGGATTCTGGCACGATGGTTCGAGCAGTGGGTGATGAGA TGGGCACTGTCCGAGTAGCCAGCACCATGACTGATGGAGCCAATACTATGATTGAGCACGATGACACGTTGCCATCACAACTGGGCACCA TGGTGATCAATGCAGAGGATGAGGAAGAGGAAGGAACTATGAAAATGGCAGAGGACGACAGCAGCTGTGAGGTGAACGGCCGCCTGTATC GGGAAGGGGAGACCTTCCAGCCCCACTGCAGCATCCGCTGCCGCTGCGAGGACGGCGGCTTCACCTGCGTGCCGCTGTGCAGCGAGGATG TGCGGCTGCCCAGCTGGGACTGCCCCCACCCCAGGAGGGTCGAGGTCCTGGGCAAGTGCTGCCCTGAGTGGGTGTGCGGCCAAGGAGGGG GACTGGGGACCCAGCCCCTTCCAGCCCAAGGACCCCAGTTTTCTGGCCTTGTCTCTTCCCTGCCCCCTGGTGTCCCCTGCCCAGAATGGA GCACGGCCTGGGGACCCTGCTCGACCACCTGTGGGCTGGGCATGGCCACCCGGGTGTCCAACCAGAACCGCTTCTGCCGACTGGAGACCC AGCGCCGCCTGTGCCTGTCCAGGCCCTGCCCACCCTCCAGGGGTCGCAGTCCACAAAACAGTGCCTTCTAGAGCCGGGCTGGGAATGGGG ACACGGTGTCCACCATCCCCAGCTGGTGGCCCTGTGCCTGGGCCCTGGGCTGATGGAAGATGGTCCGTGCCCAGGCCCTTGGCTGCAGGC AACACTTTAGCTTGGGTCCACCATGCAGAACACCAATATTAACACGCTGCCTGGTCTGTCTGGATCCCGAGGTATGGCAGAGGTGCAAGA CCTAGTCCCCTTTCCTCTAACTCACTGCCTAGGAGGCTGGCCAAGGTGTCCAGGGTCCTCTAGCCCACTCCCTGCCTACACACACAGCCT ATATCAAACATGCACACGGGCGAGCTTTCTCTCCGACTTCCCCTGGGCAAGAGATGGGACAAGCAGTCCCTTAATATTGAGGCTGCAGCA GGTGCTGGGCTGGACTGGCCATTTTTCTGGGGGTAGGATGAAGAGAAGGCACACAGAGATTCTGGATCTCCTGCTGCCTTTTCTGGAGTT >87606_87606_3_STK4-WISP2_STK4_chr20_43629994_ENST00000396731_WISP2_chr20_43353379_ENST00000372868_length(amino acids)=540AA_BP=383 METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYG SYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAK RNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRA TATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDT LPSQLGTMVINAEDEEEEGTMKMAEDDSSCEVNGRLYREGETFQPHCSIRCRCEDGGFTCVPLCSEDVRLPSWDCPHPRRVEVLGKCCPE WVCGQGGGLGTQPLPAQGPQFSGLVSSLPPGVPCPEWSTAWGPCSTTCGLGMATRVSNQNRFCRLETQRRLCLSRPCPPSRGRSPQNSAF -------------------------------------------------------------- >87606_87606_4_STK4-WISP2_STK4_chr20_43629994_ENST00000499879_WISP2_chr20_43353379_ENST00000372868_length(transcript)=2005nt_BP=1025nt AGGATGGAGCAGTGAGCGGGTCTGGGCGGCTGCTGGCAGCGCCATGGAGACGGTACAGCTGAGGAACCCGCCGCGCCGGCAGCTGAAAAA GTTGGATGAAGATAGTTTAACCAAACAACCAGAAGAAGTATTTGATGTCTTAGAGAAACTTGGAGAAGGGTCCTATGGCAGCGTATACAA AGCTATTCATAAAGAGACCGGCCAGATTGTTGCTATTAAGCAAGTTCCTGTGGAATCAGACCTCCAGGAGATAATCAAAGAAATCTCTAT AATGCAGCAATGTGACAGCCCTCATGTAGTCAAATATTATGGCAGTTATTTTAAGAACACAGACTTATGGATCGTTATGGAGTACTGTGG GGCTGGTTCTGTATCTGATATCATTCGATTACGAAATAAAACGGATACCATGGCCAAGCGGAATACAGTGATAGGAACACCATTTTGGAT GGCTCCAGAAGTGATTCAGGAAATTGGATACAACTGTGTAGCAGACATCTGGTCCCTGGGAATAACTGCCATAGAAATGGCTGAAGGAAA GCCCCCTTATGCTGATATCCATCCAATGAGGGCAATCTTCATGATTCCTACAAATCCTCCTCCCACATTCCGAAAACCAGAGCTATGGTC AGATAACTTTACAGATTTTGTGAAACAGTGTCTTGTAAAGAGCCCTGAGCAGAGGGCCACAGCCACTCAGCTCCTGCAGCACCCATTTGT CAGGAGTGCCAAAGGAGTGTCAATACTGCGAGACTTAATTAATGAAGCCATGGATGTGAAACTGAAACGCCAGGAATCCCAGCAGCGGGA AGTGGACCAGGACGATGAAGAAAACTCAGAAGAGGATGAAATGGATTCTGGCACGATGGTTCGAGCAGTGGGTGATGAGATGGGCACTGT CCGAGTAGCCAGCACCATGACTGATGGAGCCAATACTATGATTGAGCACGATGACACGTTGCCATCACAACTGGGCACCATGGTGATCAA TGCAGAGGATGAGGAAGAGGAAGGAACTATGAAAATGGCAGAGGACGACAGCAGCTGTGAGGTGAACGGCCGCCTGTATCGGGAAGGGGA GACCTTCCAGCCCCACTGCAGCATCCGCTGCCGCTGCGAGGACGGCGGCTTCACCTGCGTGCCGCTGTGCAGCGAGGATGTGCGGCTGCC CAGCTGGGACTGCCCCCACCCCAGGAGGGTCGAGGTCCTGGGCAAGTGCTGCCCTGAGTGGGTGTGCGGCCAAGGAGGGGGACTGGGGAC CCAGCCCCTTCCAGCCCAAGGACCCCAGTTTTCTGGCCTTGTCTCTTCCCTGCCCCCTGGTGTCCCCTGCCCAGAATGGAGCACGGCCTG GGGACCCTGCTCGACCACCTGTGGGCTGGGCATGGCCACCCGGGTGTCCAACCAGAACCGCTTCTGCCGACTGGAGACCCAGCGCCGCCT GTGCCTGTCCAGGCCCTGCCCACCCTCCAGGGGTCGCAGTCCACAAAACAGTGCCTTCTAGAGCCGGGCTGGGAATGGGGACACGGTGTC CACCATCCCCAGCTGGTGGCCCTGTGCCTGGGCCCTGGGCTGATGGAAGATGGTCCGTGCCCAGGCCCTTGGCTGCAGGCAACACTTTAG CTTGGGTCCACCATGCAGAACACCAATATTAACACGCTGCCTGGTCTGTCTGGATCCCGAGGTATGGCAGAGGTGCAAGACCTAGTCCCC TTTCCTCTAACTCACTGCCTAGGAGGCTGGCCAAGGTGTCCAGGGTCCTCTAGCCCACTCCCTGCCTACACACACAGCCTATATCAAACA TGCACACGGGCGAGCTTTCTCTCCGACTTCCCCTGGGCAAGAGATGGGACAAGCAGTCCCTTAATATTGAGGCTGCAGCAGGTGCTGGGC TGGACTGGCCATTTTTCTGGGGGTAGGATGAAGAGAAGGCACACAGAGATTCTGGATCTCCTGCTGCCTTTTCTGGAGTTTGTAAAATTG >87606_87606_4_STK4-WISP2_STK4_chr20_43629994_ENST00000499879_WISP2_chr20_43353379_ENST00000372868_length(amino acids)=485AA_BP=328 METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYG SYFKNTDLWIVMEYCGAGSVSDIIRLRNKTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFM IPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEM DSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKMAEDDSSCEVNGRLYREGETFQPHCSIRCRCED GGFTCVPLCSEDVRLPSWDCPHPRRVEVLGKCCPEWVCGQGGGLGTQPLPAQGPQFSGLVSSLPPGVPCPEWSTAWGPCSTTCGLGMATR -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for STK4-WISP2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for STK4-WISP2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for STK4-WISP2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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