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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:STON2-SEL1L (FusionGDB2 ID:87665)

Fusion Gene Summary for STON2-SEL1L

Fusion gene summary

Fusion gene information	Fusion gene name: STON2-SEL1L
	Fusion gene ID: 87665
		Hgene	Tgene
	Gene symbol	STON2	SEL1L
	Gene ID	85439	6400
	Gene name	stonin 2	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase
	Synonyms	STN2\|STNB\|STNB2	Hrd3\|PRO1063\|SEL1-LIKE\|SEL1L1
	Cytomap	14q31.1	14q31.1
	Type of gene	protein-coding	protein-coding
	Description	stonin-2stoned B homolog 2	protein sel-1 homolog 1SEL1L, ERAD E3 ligase adaptor subunitSuppressor of lin 12 (sel-1), C. elegans, homolog ofsel-1 suppressor of lin-12-like 1suppressor of lin-12-like protein 1
	Modification date	20200320	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000555447, ENST00000267540, ENST00000556280,	ENST00000336735, ENST00000555824,
Fusion gene scores	* DoF score	5 X 4 X 5=100	6 X 7 X 2=84
	# samples	5	7
	** MAII score	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/84*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: STON2 [Title/Abstract] AND SEL1L [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	STON2(81837332)-SEL1L(81972585), # samples:1
Anticipated loss of major functional domain due to fusion event.	STON2-SEL1L seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across STON2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SEL1L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-OX-A56R-01A	STON2	chr14	81837332	-	SEL1L	chr14	81972585	-

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Fusion Gene ORF analysis for STON2-SEL1L

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000555447	ENST00000336735	STON2	chr14	81837332	-	SEL1L	chr14	81972585	-
Frame-shift	ENST00000555447	ENST00000555824	STON2	chr14	81837332	-	SEL1L	chr14	81972585	-
In-frame	ENST00000267540	ENST00000336735	STON2	chr14	81837332	-	SEL1L	chr14	81972585	-
In-frame	ENST00000267540	ENST00000555824	STON2	chr14	81837332	-	SEL1L	chr14	81972585	-
intron-3CDS	ENST00000556280	ENST00000336735	STON2	chr14	81837332	-	SEL1L	chr14	81972585	-
intron-3CDS	ENST00000556280	ENST00000555824	STON2	chr14	81837332	-	SEL1L	chr14	81972585	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000267540	STON2	chr14	81837332	-	ENST00000336735	SEL1L	chr14	81972585	-	8240	772	201	2816	871
ENST00000267540	STON2	chr14	81837332	-	ENST00000555824	SEL1L	chr14	81972585	-	1974	772	201	1337	378

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000267540	ENST00000336735	STON2	chr14	81837332	-	SEL1L	chr14	81972585	-	0.000419384	0.99958056
ENST00000267540	ENST00000555824	STON2	chr14	81837332	-	SEL1L	chr14	81972585	-	0.005641403	0.9943586

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Fusion Genomic Features for STON2-SEL1L

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for STON2-SEL1L

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:81837332/chr14:81972585)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000336735

770_793

113

795.0

Compositional bias

Note=Pro-rich

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000555824

770_793

113

302.0

Compositional bias

Note=Pro-rich

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000336735

122_170

113

795.0

Domain

Fibronectin type-II

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000555824

122_170

113

302.0

Domain

Fibronectin type-II

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000336735

352_537

113

795.0

Region

Important for homodimerization and oligomerization

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000336735

738_794

113

795.0

Region

Note=Mediates retention in the endoplasmic reticulum

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000555824

352_537

113

302.0

Region

Important for homodimerization and oligomerization

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000555824

738_794

113

302.0

Region

Note=Mediates retention in the endoplasmic reticulum

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000336735

183_218

113

795.0

Repeat

Note=Sel1-like 1

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000336735

219_254

113

795.0

Repeat

Note=Sel1-like 2

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000336735

255_290

113

795.0

Repeat

Note=Sel1-like 3

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000336735

291_326

113

795.0

Repeat

Note=Sel1-like 4

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000336735

373_409

113

795.0

Repeat

Note=Sel1-like 5

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000336735

410_446

113

795.0

Repeat

Note=Sel1-like 6

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000336735

447_482

113

795.0

Repeat

Note=Sel1-like 7

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000336735

483_518

113

795.0

Repeat

Note=Sel1-like 8

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000336735

519_554

113

795.0

Repeat

Note=Sel1-like 9

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000336735

627_662

113

795.0

Repeat

Note=Sel1-like 10

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000336735

664_699

113

795.0

Repeat

Note=Sel1-like 11

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000555824

183_218

113

302.0

Repeat

Note=Sel1-like 1

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000555824

219_254

113

302.0

Repeat

Note=Sel1-like 2

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000555824

255_290

113

302.0

Repeat

Note=Sel1-like 3

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000555824

291_326

113

302.0

Repeat

Note=Sel1-like 4

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000555824

373_409

113

302.0

Repeat

Note=Sel1-like 5

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000555824

410_446

113

302.0

Repeat

Note=Sel1-like 6

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000555824

447_482

113

302.0

Repeat

Note=Sel1-like 7

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000555824

483_518

113

302.0

Repeat

Note=Sel1-like 8

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000555824

519_554

113

302.0

Repeat

Note=Sel1-like 9

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000555824

627_662

113

302.0

Repeat

Note=Sel1-like 10

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000555824

664_699

113

302.0

Repeat

Note=Sel1-like 11

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000336735

760_794

113

795.0

Topological domain

Cytoplasmic

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000555824

760_794

113

302.0

Topological domain

Cytoplasmic

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000336735

739_759

113

795.0

Transmembrane

Helical

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000555824

739_759

113

302.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

STON2

chr14:81837332

chr14:81972585

ENST00000267540

427_560

190

906.0

Domain

SHD

Hgene

STON2

chr14:81837332

chr14:81972585

ENST00000267540

568_878

190

906.0

Domain

MHD

Hgene

STON2

chr14:81837332

chr14:81972585

ENST00000555447

427_560

190

921.0

Domain

SHD

Hgene

STON2

chr14:81837332

chr14:81972585

ENST00000555447

568_878

190

921.0

Domain

MHD

Hgene

STON2

chr14:81837332

chr14:81972585

ENST00000267540

313_315

190

906.0

Motif

Note=NPF 1

Hgene

STON2

chr14:81837332

chr14:81972585

ENST00000267540

329_331

190

906.0

Motif

Note=NPF 2

Hgene

STON2

chr14:81837332

chr14:81972585

ENST00000555447

313_315

190

921.0

Motif

Note=NPF 1

Hgene

STON2

chr14:81837332

chr14:81972585

ENST00000555447

329_331

190

921.0

Motif

Note=NPF 2

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000336735

22_738

113

795.0

Topological domain

Lumenal

Tgene

SEL1L

chr14:81837332

chr14:81972585

ENST00000555824

22_738

113

302.0

Topological domain

Lumenal

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Fusion Gene Sequence for STON2-SEL1L

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>87665_87665_1_STON2-SEL1L_STON2_chr14_81837332_ENST00000267540_SEL1L_chr14_81972585_ENST00000336735_length(transcript)=8240nt_BP=772nt
CAGATTTCTGCCTGGCAGATTAACCAACGGCAAGAGAGGCTGATCTGTCTACATTCTGAGTACTGCCCTTGGCAAGACACCTAGAACAGA
CCCTGGACCCAAGTCTACCGTACTACCATACCCCTACTCCAGCCCACCCCAGACAGTATTCTGGGGTTCACCTGAGGTCAGCAGTGTGAA
GATGACCAGTGCCTTTTTAGCATGACGACTTTGGACCATGTGATTGCCACCCACCAGTCAGAATGGGTCTCCTTCAATGAAGAGCCACCC
TTTCCTGCCCACTCGCAGGGGGGCACGGAAGAGCACCTCCCAGGACTGTCATCTTCCCCAGACCAGTCCGAGAGCTCCTCCGGGGAGAAC
CATGTGGTGGATGGAGGCTCTCAAGACCATTCCCACTCGGAGCAGGATGACTCCTCTGAAAAGATGGGCCTCATCTCTGAAGCAGCTTCC
CCACCTGGGAGCCCTGAGCAGCCCCCACCTGACCTGGCCTCGGCCATCAGCAACTGGGTTCAGTTTGAAGATGACACACCCTGGGCCAGC
ACATCTCCACCTCATCAGGAAACAGCTGAGACAGCCCTACCATTGACCATGCCCTGCTGGACATGCCCTTCCTTTGACTCCCTGGGGAGA
TGCCCTCTGACTTCTGAGAGCAGCTGGACCACCCATTCTGAAGACACCAGCAGTCCTAGCTTTGGATGTTCGTATACAGATCTGCAGCTC
ATCAATGCTGAGGAGCAGACGAGTGGCCAGGCTTCTGGGGCTGACTCAACTGCTTTGACCGCCATTGAAGGCACAGCACATGGGGAGCCC
TGCCACTTCCCTTTTCTTTTCCTAGATAAGGAGTATGATGAATGTACATCAGATGGGAGGGAAGATGGCAGACTGTGGTGTGCTACAACC
TATGACTACAAAGCAGATGAAAAGTGGGGCTTTTGTGAAACTGAAGAAGAGGCTGCTAAGAGACGGCAGATGCAGGAAGCAGAAATGATG
TATCAAACTGGAATGAAAATCCTTAATGGAAGCAATAAGAAAAGCCAAAAAAGAGAAGCATATCGGTATCTCCAAAAGGCAGCAAGCATG
AACCATACCAAAGCCCTGGAGAGAGTGTCATATGCTCTTTTATTTGGTGATTACTTGCCACAGAATATCCAGGCAGCGAGAGAGATGTTT
GAGAAGCTGACTGAGGAAGGCTCTCCCAAGGGACAGACTGCTCTTGGCTTTCTGTATGCCTCTGGACTTGGTGTTAATTCAAGTCAGGCA
AAGGCTCTTGTATATTATACATTTGGAGCTCTTGGGGGCAATCTAATAGCCCACATGGTTTTGGGTTACAGATACTGGGCTGGCATCGGC
GTCCTCCAGAGTTGTGAATCTGCCCTGACTCACTATCGTCTTGTTGCCAATCATGTTGCTAGTGATATCTCGCTAACAGGAGGCTCAGTA
GTACAGAGAATACGGCTGCCTGATGAAGTGGAAAATCCAGGAATGAACAGTGGAATGCTAGAAGAAGATTTGATTCAATATTACCAGTTC
CTAGCTGAAAAAGGTGATGTACAAGCACAGGTTGGTCTTGGACAACTGCACCTGCACGGAGGGCGTGGAGTAGAACAGAATCATCAGAGA
GCATTTGACTACTTCAATTTAGCAGCAAATGCTGGCAATTCACATGCCATGGCCTTTTTGGGAAAGATGTATTCGGAAGGAAGTGACATT
GTACCTCAGAGTAATGAGACAGCTCTCCACTACTTTAAGAAAGCTGCTGACATGGGCAACCCAGTTGGACAGAGTGGGCTTGGAATGGCC
TACCTCTATGGGAGAGGAGTTCAAGTTAATTATGATCTAGCCCTTAAGTATTTCCAGAAAGCTGCTGAACAAGGCTGGGTGGATGGGCAG
CTACAGCTTGGTTCCATGTACTATAATGGCATTGGAGTCAAGAGAGATTATAAACAGGCCTTGAAGTATTTTAATTTAGCTTCTCAGGGA
GGCCATATCTTGGCTTTCTATAACCTAGCTCAGATGCATGCCAGTGGCACCGGCGTGATGCGATCATGTCACACTGCAGTGGAGTTGTTT
AAGAATGTATGTGAACGAGGCCGTTGGTCTGAAAGGCTTATGACTGCCTATAACAGCTATAAAGATGGCGATTACAATGCTGCAGTGATC
CAGTACCTCCTCCTGGCTGAACAGGGCTATGAAGTGGCACAAAGCAATGCAGCCTTTATTCTTGATCAGAGAGAAGCAAGCATTGTAGGT
GAGAATGAAACTTATCCCAGAGCTTTGCTACATTGGAACAGGGCCGCCTCTCAAGGCTATACTGTGGCTAGAATTAAGCTCGGAGACTAC
CATTTCTATGGGTTTGGCACCGATGTAGATTATGAAACTGCATTTATTCATTACCGTCTGGCTTCTGAGCAGCAACACAGTGCACAAGCT
ATGTTTAATCTGGGATATATGCATGAGAAAGGACTGGGCATTAAACAGGATATTCACCTTGCGAAACGTTTTTATGACATGGCAGCTGAA
GCCAGCCCAGATGCACAAGTTCCAGTCTTCCTAGCCCTCTGCAAATTGGGCGTCGTCTATTTCTTGCAGTACATACGGGAAACAAACATT
CGAGATATGTTCACCCAACTTGATATGGACCAGCTTTTGGGACCTGAGTGGGACCTTTACCTCATGACCATCATTGCGCTGCTGTTGGGA
ACAGTCATAGCTTACAGGCAAAGGCAGCACCAAGACATGCCTGCACCCAGGCCTCCAGGGCCACGGCCAGCTCCACCCCAGCAGGAGGGG
CCACCAGAGCAGCAGCCACCACAGTAATAGGCACTGGGTCCAGCCTTGATCAGTGACAGCGAAGGAAGTTATCTGCTGGGAACACTTGCA
TTTGATTTAGGACCTTGGATCAGTGGTCACCTCCCAGAAGAGGCACGGCACAAGGAAGCATTGAATTCCTAAAGCTGCTTAGAATCTGAT
GCCTTTATTTTCAGGGATAAGTAACTCTTACCTAAACTGAGCTGAATGTTTGTTTCAGTGCCATATGGAATAACAACTTTCAGTGGCTTT
TTTTTTTCTTTTCTGGAAACATATGTGAGACACTCAGAGTAATGTCTACTGTATCCAGCTATCTTTCTTGGATCCTTTTGGTCATTATTT
CAGTGTGCATAAGTTCTTAATGTCAACCATCTTTAAGGTATTGTGCATCGACACTAAAAACTGATCAGTGTAAAAAGGAAAACCCAGTTG
CAAGTTTAAACGTGTTCGAAAGTCTGAAAATAGAACTTGCCTTTTAAGTTAAAAAAAAAAAAAGCTATCTTGAAAATGTTTTGGAACTGC
GATAACTGAGAAACTCTTACCAGTCCACATGCAATTAGACATATTCAGCATATTTGTTATTTTAAAAGGGAGGGTTGGGAGGTTTCTTAT
TGGTGATTGTCACACGGTATACCATACTCCTCTCCTTCAAAGAATGAAAGGCCTTGTTAAGGAGTTTTTTGTGAGCTTTACTTCTTTGGA
ATGGAATATACTTATGCAAAACCTTGTGAACTGACTCCTTGCACTAACGCGAGTTTGCCCCACCTACTCTGTAATTTGCTTGTTTGTTTT
GAATATACAGAGCCTTGATCCAGAAGCCAGAGGATGGACTAAGTGGGAGAAATTAGAAAACAAAACGAACTCTGGTTGGGGTACTACGAT
CACAGACACAGACATACTTTTCCTAAAGTTGAAGCATTTGTTCCCAGGATTTATTTTACTTTGCATTTCTTTTTGCACAAAGAACACATC
ACCTTCCTGAATTCTTTAAATATGAAATATCATTGCCAGGGTATGGCTTACAGTGACTACTATTATAATACTAAAACTCAGAGAATCAAA
GATGGATTAAACTCAGTGGTTGATGAAAGCCAAAACCTGTTTGTACTGTTCTATACTATTCAGGTATCTTTTTATTTCTGATAGTTTTAT
ATTATAATAGAAAGCCAGCCACTGCTTAGCTATCATAGTCACCATTTTCTCACTGTTAACATTAGGAAAATCAAGGCTACTATGCTTCAG
GATTGTCTGGTTAAATAGTATGGGAAAAAAACTGAAGAGTTTCACATAATTACACACGTGAAATAATTAAAGCTTAAACTGAATTTGTAT
TTCATTTTATTGTCAGATGGTGGTGTTCACCAGCCTGTATCTTGTCTGAGACTGCATTCGTATCTGAGCAGGTTTTCTATGCCTACTGAT
GTCAGTATGTTTATACTAACCTTCATGCTTTTTTCCCAGAATCCCTCATCTGCCAGAAAACTTGAAAAGTTTATTGCTTGTAGAGTTGTA
CTGCTTTGATTTTTGAAGTTGGGGTAGTAGTTAGAACTAGATTTAACTAGTCTATAATGAACATGAAGGCTTTTATATATGAAGTTGTAT
ACCTTTTTGTGTTTAGAGAATTATGGGAAACCTGGTAAGCAAAACTTTCCTCCCAGATAATTGCTTCCAAATTCGAAGAGTTAGTCACCA
AGAGAGCCATATGTATGAAAGCGTATCTGTGAAAGGTAGGAAACTTACCCCCCCTAAGTGTAATGTTGCTTTAGGCAACTCTTGTAAATA
GTGAGACTTGTTTGGTCTCTTACATGTAGAGATTTGAGTGCAGTTGGTACAGTACTTTGGTGTCTCCACCACTGTCCCTTCTCCCCGCTT
CAAAATAAGTGTAATCCACGGTAGCAGCCACACTTCCTTTAGAAGGAACTGTTATAATTTATTTAAAAGTTGAAAAACCACCCAAGATGA
CTACCAACTTTCACTTTTTTCTTCTGCCATCCACCCTCATTTTTCCTTTAGCAAGATTTTTATATCTAACTTTCCTTCCCTCCATTGAGT
ACGTGCTTTGAGAAAACATTTCTTAAAACAGTGTGTGCCACCTAAGGCTGGATGGGAAAGTGCAGTCTTGTTGTTCATATAAAAACACAC
TTCTTATTAGTTTACCACTTGCCTTTTTCTATTGTTAATGTTCTGAATTTCCTTTTCTTGGCTTGTTTCTACTTCATTTTACCCTGGGTC
ACTTGCTGCCAGCAGTTTGTGAATGGTGTCTTTCAAATAACTTAGTTCTTATGGCTTCACTTAAAGACTGTCTCAAAAATACTTTGCTCT
CTTCTTCTTTTTTGTTCATGGGACATGGTACCTAAGCAAATAGGAGTTGGGTTTGGTTTTTCTCCTAAAATAATGCTCAATACTTACCTA
ATCAAATGGCATCCATTTGAATAAAATGACAATAACTAAAGCTAGTTAATGTCAGTGACATTAAACTAACTCCAGGATTCAGGAGTTTTA
ATGTTAGAATTTAGATTTAACAGATAGAGTGTGGCTTCATTTGTCCATGGTAGCCCATCTCTCCTAAGACCTTTTCTAGTCTGTCTTCCT
GCCTTCGAACTTGATGACAGTAAAACCCTGTTTAGTATTCTCTTGTGCATTTGGTTTGTTGGTTAGCCGACTGTCTTGAAACTATTCATT
TTGCTTCTAGTTTTATTTTACAGAGGTAGCATTGGTGGGTTTTTTTTTTTTTTTCTGTCTCTGTGTTTGAAGTTTCAGTTTCTGTTTTCT
AGGTAAGGCTTATTTTTGATTAGCAGTCAATGGCAAAGAAAAAGTAAATCAAAGATGACTTCTTTTCAAAATGTATTGTTTAGCACTTAA
CTCAGATGAATTTATAAATTATTAATCTTGATACTAAGGATTTGTTACTTTTTTGCATATTAGGTTAATTTTTACCTTACATGTGAGAGT
CTTACCACTAAGCCATTCTGTCTCTGTACTGTTGGGAAGTTTTGGAAACCCCTGCCAGTGATCTGGTGATGATCTGATGATTTATTTAAA
GAGCCGTTGATGCCTCCAGGAAACTTAAGTATTTTATTAATATATATATAGGAATTTTTTTTTATTTTGCTTTGTCTTTCTCTCCCTTCT
TTTATCCTCATGTTCATTCTTCAAACCAGTGTTTTGGAAGTATGCATGCAGGCCTATAAATGAAAAACACAATTCTTTATGTGTATAGCA
TGTGTATTAATGTCTAACTACATACGCAAAAACTTCCTTTACAGAGGTTCGGACTAACATTTCACATGCACATTTCAAAACAAGATGTGT
CATGAAAACAGCCCCTTTACCTGCCAAGACAAGCAGGGCTATATTTCAGTGACAGCTGATATTTGTTTTGAAAGTGAATCTCATAATATA
TATATGTATTACACATTATTATGACTAGAAGTATGTAAGAAATGATCAGAACAAAAGAAAATTTCTATTTTCATGCAAATATTTTTCATC
AGTCATCACTCTCAAATATAAATTAAAATATAACACTCCTGAATGCCTGAGGCACGATCTGGATTTTAAATGTGTGGTATTCATTGAAAA
GAAGCTCTCCACCCACTTGGTATTTCAAGAAAATTTAAAACGATCCCAAGGAAAGATGATTTGTATGTTAAAGTGACTGCACAAGTAAAA
GTCCAATGTTGTGTGCATGAAAAGGATTCCTTGGTTATGTGCAGGGAATCATCTCACATGCTGTTTTTCCTATTTGGTTTGAGAAACAGG
CTGACACTATTCTCTTTGATTAGAAAATAAACTCATAAAACTCATAATGTTGATATAATCAAGATGTAACCACTATAAATATGTAGAAGA
GGAAGTTTTAAAAGACCTTAAGCTGGCATTGTGAAGGAACACCATGGTAGACTCTTTTTGTAAATGTATTTTGTATTTAATGAAATGCAG
TATAAAGGTTGGTGAAGTGTAATATAATTGTGTAAACAAATCCTGTTAATAGAGAGATGTACAGAATCGTTTTGTACTGTATCTTGAAAC
TTGTGAAATAAAGATTCCACCTCTGGTTATCCTGTATGCTGTAATATACCACAACCAAGCACCTTTCCAGACAGACTTTTTTTAAGCTGA
ATGATTCAATTTTTTAATGTTTTTTGGAAATTCAGAAGCTTCTGAAAACATTCACTTGTGGCAATTTGAATTTATCTTTCATTTTAAACT
CCTGAAATTCAGATTTTTACAAGTCCAATATTGCCCTAGGGAGAACATGAATTTGCTAAGAAATGTTATCTTTTAAATCTCTGATATCTT
TGTCTTGAAGCAGCCTTGATATGTAGTAAGCGTGATTCACTTTAGCCTGATTATAATATTATTTATCTAAAGTTTGTTTATGCATTGCCT
TGTCCCAGGAATTTTTTAAGAGGACTTGCAGAGACACGTACCACACAGTAACATTTAGACTAAATATGCTCTGAGTAAAGGAGAAATGAA
AAAATATTAAATCAAGAGTGAACATGTACACAAAGTGCAATTGGAAGTGGGCTACAAATTTGGCCCCCAGCTTCCCAGCAGGCAACTCAA
AGAGGTAACTGAGGTAAAATGTTCCAGCTCAGAAGCATTGGATCTTGGATAAAAAGCCTACATGATGCAAACTGTGGCAACTGAGATGTC
AGATCTCAAGATCTCAAATTGTACTTGTGGGAGCACAGTCAGTGACCCCAGATGACCTTGACTGACCTAAAAGTTGTGGGGGAAGTCGGA
TGTCAGAGCCTTAACACCAGCAGGTGACCATCCAACCTGGGGCAATGCCTGCCTGTTCACCACTTAGCCTCTTTCTGGCAAGTCATTAGA
ATGTCCTCCATCTTCATTGGCTGCAACTTGATGAGCTACAGCCTCTTTCCTAACTTCCTTTATGATGCTAGTTTAGGTTGGTTATACCAG
CTTGGAAGTATGCTTAGATTAAGTTACAGCAGATACACAAATTAGATGCAAGTAAAAAAAATCAGAATTTCTGTAGTAGAAACTACGAAA
AATAAAAAGGAAAGTTTTTACTTTTTGGGTATTTTTTTACGAATAAGAAAAAGTGAGCGTTAATCAGTTCAAAAGGAGGTACTGCTGTGT
AATGGGCTTTGTACGTTCCTTCTCATGTCACTTACGTCACTACTTCGCCATCAAATTGAACAAGCTTTTAATTAGATCCTGAAAATTCAC
TATGCTAGTAGTTTATTGGTAGTATTATATTTTGAGTAGAACTCTGATTTTCCCTAGAGGCCAAATTCTTTTTATCTGGGTTAATTTCTT
TTAAACATAACAATGTTAATGCTGAATTGTATATTAAATCCCATTTCTAAAAACCACACAATTTTTTCTCATGTAAGTTGAGTGGAATGT

>87665_87665_1_STON2-SEL1L_STON2_chr14_81837332_ENST00000267540_SEL1L_chr14_81972585_ENST00000336735_length(amino acids)=871AA_BP=190
MTTLDHVIATHQSEWVSFNEEPPFPAHSQGGTEEHLPGLSSSPDQSESSSGENHVVDGGSQDHSHSEQDDSSEKMGLISEAASPPGSPEQ
PPPDLASAISNWVQFEDDTPWASTSPPHQETAETALPLTMPCWTCPSFDSLGRCPLTSESSWTTHSEDTSSPSFGCSYTDLQLINAEEQT
SGQASGADSTALTAIEGTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFCETEEEAAKRRQMQEAEMMYQTGMKI
LNGSNKKSQKREAYRYLQKAASMNHTKALERVSYALLFGDYLPQNIQAAREMFEKLTEEGSPKGQTALGFLYASGLGVNSSQAKALVYYT
FGALGGNLIAHMVLGYRYWAGIGVLQSCESALTHYRLVANHVASDISLTGGSVVQRIRLPDEVENPGMNSGMLEEDLIQYYQFLAEKGDV
QAQVGLGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNETALHYFKKAADMGNPVGQSGLGMAYLYGRGV
QVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAFYNLAQMHASGTGVMRSCHTAVELFKNVCERG
RWSERLMTAYNSYKDGDYNAAVIQYLLLAEQGYEVAQSNAAFILDQREASIVGENETYPRALLHWNRAASQGYTVARIKLGDYHFYGFGT
DVDYETAFIHYRLASEQQHSAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEASPDAQVPVFLALCKLGVVYFLQYIRETNIRDMFTQL

--------------------------------------------------------------
>87665_87665_2_STON2-SEL1L_STON2_chr14_81837332_ENST00000267540_SEL1L_chr14_81972585_ENST00000555824_length(transcript)=1974nt_BP=772nt
CAGATTTCTGCCTGGCAGATTAACCAACGGCAAGAGAGGCTGATCTGTCTACATTCTGAGTACTGCCCTTGGCAAGACACCTAGAACAGA
CCCTGGACCCAAGTCTACCGTACTACCATACCCCTACTCCAGCCCACCCCAGACAGTATTCTGGGGTTCACCTGAGGTCAGCAGTGTGAA
GATGACCAGTGCCTTTTTAGCATGACGACTTTGGACCATGTGATTGCCACCCACCAGTCAGAATGGGTCTCCTTCAATGAAGAGCCACCC
TTTCCTGCCCACTCGCAGGGGGGCACGGAAGAGCACCTCCCAGGACTGTCATCTTCCCCAGACCAGTCCGAGAGCTCCTCCGGGGAGAAC
CATGTGGTGGATGGAGGCTCTCAAGACCATTCCCACTCGGAGCAGGATGACTCCTCTGAAAAGATGGGCCTCATCTCTGAAGCAGCTTCC
CCACCTGGGAGCCCTGAGCAGCCCCCACCTGACCTGGCCTCGGCCATCAGCAACTGGGTTCAGTTTGAAGATGACACACCCTGGGCCAGC
ACATCTCCACCTCATCAGGAAACAGCTGAGACAGCCCTACCATTGACCATGCCCTGCTGGACATGCCCTTCCTTTGACTCCCTGGGGAGA
TGCCCTCTGACTTCTGAGAGCAGCTGGACCACCCATTCTGAAGACACCAGCAGTCCTAGCTTTGGATGTTCGTATACAGATCTGCAGCTC
ATCAATGCTGAGGAGCAGACGAGTGGCCAGGCTTCTGGGGCTGACTCAACTGCTTTGACCGCCATTGAAGGCACAGCACATGGGGAGCCC
TGCCACTTCCCTTTTCTTTTCCTAGATAAGGAGTATGATGAATGTACATCAGATGGGAGGGAAGATGGCAGACTGTGGTGTGCTACAACC
TATGACTACAAAGCAGATGAAAAGTGGGGCTTTTGTGAAACTGAAGAAGAGGCTGCTAAGAGACGGCAGATGCAGGAAGCAGAAATGATG
TATCAAACTGGAATGAAAATCCTTAATGGAAGCAATAAGAAAAGCCAAAAAAGAGAAGCATATCGGTATCTCCAAAAGGCAGCAAGCATG
AACCATACCAAAGCCCTGGAGAGAGTGTCATATGCTCTTTTATTTGGTGATTACTTGCCACAGAATATCCAGGCAGCGAGAGAGATGTTT
GAGAAGCTGACTGAGGAAGGCTCTCCCAAGGGACAGACTGCTCTTGGCTTTCTGTATGCCTCTGGACTTGGTGTTAATTCAAGTCAGGCA
AAGGCTCTTGTATATTATACATTTGGAGCTCTTGGGGGCAATCTAATAGCCCACATGGTTTTGGTAAGTAGACTTTAGTGGAAGGCTAAT
AATATTAACATCAGAAGAATTTGTGGTTTATAGCGGCCACAACTTTTTCAGCTTTCATGATCCAGATTTGCTTGTATTAAGACCAAATAT
TCAGTTGAACTTCCTTCAAATTCTTGTTAATGGATATAACACATGGAATCTACATGTAAATGAAAGTTGGTGGAGTCCACAATTTTTCTT
TAAAATGATTAGTTTGGCTGATTGCCCCTAAAAAGAGAGATCTGATAAATGGCTCTTTTTAAATTTTCTCTGAGTTGGAATTGTCAGAAT
CATTTTTTACATTAGATTATCATAATTTTAAAAATTTTTCTTTAGTTTTTCAAAATTTTGTAAATGGTGGCTATAGAAAAACAACATGAA
ATATTATACAATATTTTGCAACAATGCCCTAAGAATTGTTAAAATTCATGGAGTTATTTGTGCAGAATGACTCCAGAGAGCTCTACTTTC
TGTTTTTTACTTTTCATGATTGGCTGTCTTCCCATTTATTCTGGTCATTTATTGCTAGTGACACTGTGCCTGCTTCCAGTAGTCTCATTT

>87665_87665_2_STON2-SEL1L_STON2_chr14_81837332_ENST00000267540_SEL1L_chr14_81972585_ENST00000555824_length(amino acids)=378AA_BP=190
MTTLDHVIATHQSEWVSFNEEPPFPAHSQGGTEEHLPGLSSSPDQSESSSGENHVVDGGSQDHSHSEQDDSSEKMGLISEAASPPGSPEQ
PPPDLASAISNWVQFEDDTPWASTSPPHQETAETALPLTMPCWTCPSFDSLGRCPLTSESSWTTHSEDTSSPSFGCSYTDLQLINAEEQT
SGQASGADSTALTAIEGTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKADEKWGFCETEEEAAKRRQMQEAEMMYQTGMKI
LNGSNKKSQKREAYRYLQKAASMNHTKALERVSYALLFGDYLPQNIQAAREMFEKLTEEGSPKGQTALGFLYASGLGVNSSQAKALVYYT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for STON2-SEL1L

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	SEL1L	chr14:81837332	chr14:81972585	ENST00000336735		2	21	643_723	113.33333333333333	795.0	SYVN1
Tgene	SEL1L	chr14:81837332	chr14:81972585	ENST00000555824		2	8	643_723	113.33333333333333	302.0	SYVN1

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	SEL1L	chr14:81837332	chr14:81972585	ENST00000336735		2	21	22_737	113.33333333333333	795.0	ERLEC1%2C OS9 and SYVN1
Tgene	SEL1L	chr14:81837332	chr14:81972585	ENST00000555824		2	8	22_737	113.33333333333333	302.0	ERLEC1%2C OS9 and SYVN1

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for STON2-SEL1L

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for STON2-SEL1L

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source