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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:STRN3-PRKD1 (FusionGDB2 ID:87723)

Fusion Gene Summary for STRN3-PRKD1

Fusion gene summary

Fusion gene information	Fusion gene name: STRN3-PRKD1
	Fusion gene ID: 87723
		Hgene	Tgene
	Gene symbol	STRN3	PRKD1
	Gene ID	29966	5587
	Gene name	striatin 3	protein kinase D1
	Synonyms	PPP2R6B\|S/G2NA\|SG2NA	CHDED\|PKC-MU\|PKCM\|PKD\|PRKCM
	Cytomap	14q12	14q12
	Type of gene	protein-coding	protein-coding
	Description	striatin-3cell cycle S/G2 nuclear autoantigencell cycle autoantigen SG2NAnuclear autoantigenprotein phosphatase 2 regulatory subunit B'''betas/G2 antigenstriatin, calmodulin binding protein 3	serine/threonine-protein kinase D1nPKC-D1nPKC-muprotein kinase C mu typeprotein kinase C, muprotein kinase D
	Modification date	20200313	20200315
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000355683, ENST00000357479, ENST00000366206,	ENST00000551644, ENST00000331968, ENST00000415220,
Fusion gene scores	* DoF score	18 X 12 X 9=1944	14 X 13 X 7=1274
	# samples	18	13
	** MAII score	log2(18/1944*10)=-3.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/1274*10)=-3.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: STRN3 [Title/Abstract] AND PRKD1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	STRN3(31495110)-PRKD1(30194880), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PRKD1	GO:0006468	protein phosphorylation	24623306
Tgene	PRKD1	GO:0018105	peptidyl-serine phosphorylation	18440775
Tgene	PRKD1	GO:0018107	peptidyl-threonine phosphorylation	22095288
Tgene	PRKD1	GO:0034599	cellular response to oxidative stress	12505989
Tgene	PRKD1	GO:0046777	protein autophosphorylation	24623306

Fusion gene breakpoints across STRN3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PRKD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-44-3918-01A	STRN3	chr14	31495110	-	PRKD1	chr14	30194880	-

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Fusion Gene ORF analysis for STRN3-PRKD1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000355683	ENST00000551644	STRN3	chr14	31495110	-	PRKD1	chr14	30194880	-
5CDS-intron	ENST00000357479	ENST00000551644	STRN3	chr14	31495110	-	PRKD1	chr14	30194880	-
In-frame	ENST00000355683	ENST00000331968	STRN3	chr14	31495110	-	PRKD1	chr14	30194880	-
In-frame	ENST00000355683	ENST00000415220	STRN3	chr14	31495110	-	PRKD1	chr14	30194880	-
In-frame	ENST00000357479	ENST00000331968	STRN3	chr14	31495110	-	PRKD1	chr14	30194880	-
In-frame	ENST00000357479	ENST00000415220	STRN3	chr14	31495110	-	PRKD1	chr14	30194880	-
intron-3CDS	ENST00000366206	ENST00000331968	STRN3	chr14	31495110	-	PRKD1	chr14	30194880	-
intron-3CDS	ENST00000366206	ENST00000415220	STRN3	chr14	31495110	-	PRKD1	chr14	30194880	-
intron-intron	ENST00000366206	ENST00000551644	STRN3	chr14	31495110	-	PRKD1	chr14	30194880	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000355683	STRN3	chr14	31495110	-	ENST00000331968	PRKD1	chr14	30194880	-	3730	498	216	2972	918
ENST00000355683	STRN3	chr14	31495110	-	ENST00000415220	PRKD1	chr14	30194880	-	3293	498	216	2996	926
ENST00000357479	STRN3	chr14	31495110	-	ENST00000331968	PRKD1	chr14	30194880	-	3711	479	197	2953	918
ENST00000357479	STRN3	chr14	31495110	-	ENST00000415220	PRKD1	chr14	30194880	-	3274	479	197	2977	926

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000355683	ENST00000331968	STRN3	chr14	31495110	-	PRKD1	chr14	30194880	-	0.000487568	0.99951243
ENST00000355683	ENST00000415220	STRN3	chr14	31495110	-	PRKD1	chr14	30194880	-	0.001009736	0.99899024
ENST00000357479	ENST00000331968	STRN3	chr14	31495110	-	PRKD1	chr14	30194880	-	0.000502766	0.9994972
ENST00000357479	ENST00000415220	STRN3	chr14	31495110	-	PRKD1	chr14	30194880	-	0.001065422	0.99893457

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Fusion Genomic Features for STRN3-PRKD1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for STRN3-PRKD1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:31495110/chr14:30194880)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

STRN3

chr14:31495110

chr14:30194880

ENST00000355683

6_13

714.0

Compositional bias

Note=Poly-Gly

Hgene

STRN3

chr14:31495110

chr14:30194880

ENST00000357479

6_13

798.0

Compositional bias

Note=Poly-Gly

Hgene

STRN3

chr14:31495110

chr14:30194880

ENST00000355683

71_79

714.0

Region

Caveolin-binding

Hgene

STRN3

chr14:31495110

chr14:30194880

ENST00000357479

71_79

798.0

Region

Caveolin-binding

Tgene

PRKD1

chr14:31495110

chr14:30194880

ENST00000331968

200_203

913.0

Compositional bias

Note=Poly-Arg

Tgene

PRKD1

chr14:31495110

chr14:30194880

ENST00000331968

422_541

913.0

Domain

Tgene

PRKD1

chr14:31495110

chr14:30194880

ENST00000331968

583_839

913.0

Domain

Protein kinase

Tgene

PRKD1

chr14:31495110

chr14:30194880

ENST00000331968

589_597

913.0

Nucleotide binding

ATP

Tgene

PRKD1

chr14:31495110

chr14:30194880

ENST00000331968

146_196

913.0

Zinc finger

Phorbol-ester/DAG-type 1

Tgene

PRKD1

chr14:31495110

chr14:30194880

ENST00000331968

270_320

913.0

Zinc finger

Phorbol-ester/DAG-type 2

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

STRN3

chr14:31495110

chr14:30194880

ENST00000355683

77_136

714.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

STRN3

chr14:31495110

chr14:30194880

ENST00000357479

77_136

798.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

STRN3

chr14:31495110

chr14:30194880

ENST00000355683

166_183

714.0

Region

Calmodulin-binding

Hgene

STRN3

chr14:31495110

chr14:30194880

ENST00000357479

166_183

798.0

Region

Calmodulin-binding

Hgene

STRN3

chr14:31495110

chr14:30194880

ENST00000355683

478_517

714.0

Repeat

Note=WD 1

Hgene

STRN3

chr14:31495110

chr14:30194880

ENST00000355683

531_570

714.0

Repeat

Note=WD 2

Hgene

STRN3

chr14:31495110

chr14:30194880

ENST00000355683

584_623

714.0

Repeat

Note=WD 3

Hgene

STRN3

chr14:31495110

chr14:30194880

ENST00000355683

679_718

714.0

Repeat

Note=WD 4

Hgene

STRN3

chr14:31495110

chr14:30194880

ENST00000355683

721_760

714.0

Repeat

Note=WD 5

Hgene

STRN3

chr14:31495110

chr14:30194880

ENST00000355683

767_796

714.0

Repeat

Note=WD 6

Hgene

STRN3

chr14:31495110

chr14:30194880

ENST00000357479

478_517

798.0

Repeat

Note=WD 1

Hgene

STRN3

chr14:31495110

chr14:30194880

ENST00000357479

531_570

798.0

Repeat

Note=WD 2

Hgene

STRN3

chr14:31495110

chr14:30194880

ENST00000357479

584_623

798.0

Repeat

Note=WD 3

Hgene

STRN3

chr14:31495110

chr14:30194880

ENST00000357479

679_718

798.0

Repeat

Note=WD 4

Hgene

STRN3

chr14:31495110

chr14:30194880

ENST00000357479

721_760

798.0

Repeat

Note=WD 5

Hgene

STRN3

chr14:31495110

chr14:30194880

ENST00000357479

767_796

798.0

Repeat

Note=WD 6

Tgene

PRKD1

chr14:31495110

chr14:30194880

ENST00000331968

17_26

913.0

Compositional bias

Note=Poly-Ala

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Fusion Gene Sequence for STRN3-PRKD1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>87723_87723_1_STRN3-PRKD1_STRN3_chr14_31495110_ENST00000355683_PRKD1_chr14_30194880_ENST00000331968_length(transcript)=3730nt_BP=498nt
AAAGTGAGTGAGTGAGACGGGCAGATGGAGGAGGGATTGTAATGGCGGCAGCCGGCAGCTCCCTGCTCTGACCCACGGCAGGCACACAGC
AACGACCCCTTCCCCGCCCCTCTCCCGGCCGGCCTCCGCCCCGCAGCCAGCGCGGGGCCACCCTCTCCGGCCCTTCCCCCAGCTGTCGGC
GTCTCGCCCTGCGCCCCGGCCGGGGCCCCACACACAATGGACGAGCTTGCCGGAGGCGGTGGTGGCGGCCCGGGGATGGCGGCCCCTCCC
CGGCAGCAGCAGGGACCTGGGGGGAACCTGGGCCTTTCGCCCGGGGGGAACGGAGCGGCGGGCGGCGGGGGTCCTCCGGCCTCCGAGGGA
GCGGGTCCCGCGGCAGGCCCCGAGCTGTCCCGGCCGCAGCAGTACACTATCCCGGGGATACTGCACTACATCCAGCACGAGTGGGCTCGG
TTCGAGATGGAGCGGGCGCACTGGGAGGTGGAACGGGCCGAACTGCAGTTCCCTGAATGTGGTTTCTACGGAATGTATGATAAGATCCTG
CTTTTTCGCCATGACCCTACCTCTGAAAACATCCTTCAGCTGGTGAAAGCGGCCAGTGATATCCAGGAAGGCGATCTTATTGAAGTGGTC
TTGTCAGCTTCCGCCACCTTTGAAGACTTTCAGATTCGTCCCCACGCTCTCTTTGTTCATTCATACAGAGCTCCAGCTTTCTGTGATCAC
TGTGGAGAAATGCTGTGGGGGCTGGTACGTCAAGGTCTTAAATGTGAAGGGTGTGGTCTGAATTACCATAAGAGATGTGCATTTAAAATA
CCCAACAATTGCAGCGGTGTGAGGCGGAGAAGGCTCTCAAACGTTTCCCTCACTGGGGTCAGCACCATCCGCACATCATCTGCTGAACTC
TCTACAAGTGCCCCTGATGAGCCCCTTCTGCAAAAATCACCATCAGAGTCGTTTATTGGTCGAGAGAAGAGGTCAAATTCTCAATCATAC
ATTGGACGACCAATTCACCTTGACAAGATTTTGATGTCTAAAGTTAAAGTGCCGCACACATTTGTCATCCACTCCTACACCCGGCCCACA
GTGTGCCAGTACTGCAAGAAGCTTCTGAAGGGGCTTTTCAGGCAGGGCTTGCAGTGCAAAGATTGCAGATTCAACTGCCATAAACGTTGT
GCACCGAAAGTACCAAACAACTGCCTTGGCGAAGTGACCATTAATGGAGATTTGCTTAGCCCTGGGGCAGAGTCTGATGTGGTCATGGAA
GAAGGGAGTGATGACAATGATAGTGAAAGGAACAGTGGGCTCATGGATGATATGGAAGAAGCAATGGTCCAAGATGCAGAGATGGCAATG
GCAGAGTGCCAGAACGACAGTGGCGAGATGCAAGATCCAGACCCAGACCACGAGGACGCCAACAGAACCATCAGTCCATCAACAAGCAAC
AATATCCCACTCATGAGGGTAGTGCAGTCTGTCAAACACACGAAGAGGAAAAGCAGCACAGTCATGAAAGAAGGATGGATGGTCCACTAC
ACCAGCAAGGACACGCTGCGGAAACGGCACTATTGGAGATTGGATAGCAAATGTATTACCCTCTTTCAGAATGACACAGGAAGCAGGTAC
TACAAGGAAATTCCTTTATCTGAAATTTTGTCTCTGGAACCAGTAAAAACTTCAGCTTTAATTCCTAATGGGGCCAATCCTCATTGTTTC
GAAATCACTACGGCAAATGTAGTGTATTATGTGGGAGAAAATGTGGTCAATCCTTCCAGCCCATCACCAAATAACAGTGTTCTCACCAGT
GGCGTTGGTGCAGATGTGGCCAGGATGTGGGAGATAGCCATCCAGCATGCCCTTATGCCCGTCATTCCCAAGGGCTCCTCCGTGGGTACA
GGAACCAACTTGCACAGAGATATCTCTGTGAGTATTTCAGTATCAAATTGCCAGATTCAAGAAAATGTGGACATCAGCACAGTATATCAG
ATTTTTCCTGATGAAGTACTGGGTTCTGGACAGTTTGGAATTGTTTATGGAGGAAAACATCGTAAAACAGGAAGAGATGTAGCTATTAAA
ATCATTGACAAATTACGATTTCCAACAAAACAAGAAAGCCAGCTTCGTAATGAGGTTGCAATTCTACAGAACCTTCATCACCCTGGTGTT
GTAAATTTGGAGTGTATGTTTGAGACGCCTGAAAGAGTGTTTGTTGTTATGGAAAAACTCCATGGAGACATGCTGGAAATGATCTTGTCA
AGTGAAAAGGGCAGGTTGCCAGAGCACATAACGAAGTTTTTAATTACTCAGATACTCGTGGCTTTGCGGCACCTTCATTTTAAAAATATC
GTTCACTGTGACCTCAAACCAGAAAATGTGTTGCTAGCCTCAGCTGATCCTTTTCCTCAGGTGAAACTTTGTGATTTTGGTTTTGCCCGG
ATCATTGGAGAGAAGTCTTTCCGGAGGTCAGTGGTGGGTACCCCCGCTTACCTGGCTCCTGAGGTCCTAAGGAACAAGGGCTACAATCGC
TCTCTAGACATGTGGTCTGTTGGGGTCATCATCTATGTAAGCCTAAGCGGCACATTCCCATTTAATGAAGATGAAGACATACACGACCAA
ATTCAGAATGCAGCTTTCATGTATCCACCAAATCCCTGGAAGGAAATATCTCATGAAGCCATTGATCTTATCAACAATTTGCTGCAAGTA
AAAATGAGAAAGCGCTACAGTGTGGATAAGACCTTGAGCCACCCTTGGCTACAGGACTATCAGACCTGGTTAGATTTGCGAGAGCTGGAA
TGCAAAATCGGGGAGCGCTACATCACCCATGAAAGTGATGACCTGAGGTGGGAGAAGTATGCAGGCGAGCAGGGGCTGCAGTACCCCACA
CACCTGATCAATCCAAGTGCTAGCCACAGTGACACTCCTGAGACTGAAGAAACAGAAATGAAAGCCCTCGGTGAGCGTGTCAGCATCCTC
TGAGTTCCATCTCCTATAATCTGTCAAAACACTGTGGAACTAATAAATACATACGGTCAGGTTTAACATTTGCCTTGCAGAACTGCCATT
ATTTTCTGTCAGATGAGAACAAAGCTGTTAAACTGTTAGCACTGTTGATGTATCTGAGTTGCCAAGACAAATCAACAGAAGCATTTGTAT
TTTGTGTGACCAACTGTGTTGTATTAACAAAAGTTCCCTGAAACACGAAACTTGTTATTGTGAATGATTCATGTTATATTTAATGCATTA
AACCTGTCTCCACTGTGCCTTTGCAAATCAGTGTTTTTCTTACTGGAGCTTCATTTTGGTAAGAGACAGAATGTATCTGTGAAGTAGTTC
TGTTTGGTGTGTCCCATTGGTGTTGTCATTGTAAACAAACTCTTGAAGAGTCGATTATTTCCAGTGTTCTATGAACAACTCCAAAACCCA
TGTGGGAAAAAAATGAATGAGGAGGGTAGGGAATAAAATCCTAAGACACAAATGCATGAACAAGTTTTAATGTATAGTTTTGAATCCTTT
GCCTGCCTGGTGTGCCTCAGTATATTTAAACTCAAGACAATGCACCTAGCTGTGCAAGACCTAGTGCTCTTAAGCCTAAATGCCTTAGAA
ATGTAAACTGCCATATATAACAGATACATTTCCCTCTTTCTTATAATACTCTGTTGTACTATGGAAAATCAGCTGCTCAGCAACCTTTCA

>87723_87723_1_STRN3-PRKD1_STRN3_chr14_31495110_ENST00000355683_PRKD1_chr14_30194880_ENST00000331968_length(amino acids)=918AA_BP=92
MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQYTIPGILHYIQHEWARFEMERAHWEVER
AELQFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQG
LKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESFIGREKRSNSQSYIGRPIHLDKILM
SKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNS
GLMDDMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYW
RLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEI
AIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQE
SQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLL
ASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNP
WKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDT

--------------------------------------------------------------
>87723_87723_2_STRN3-PRKD1_STRN3_chr14_31495110_ENST00000355683_PRKD1_chr14_30194880_ENST00000415220_length(transcript)=3293nt_BP=498nt
AAAGTGAGTGAGTGAGACGGGCAGATGGAGGAGGGATTGTAATGGCGGCAGCCGGCAGCTCCCTGCTCTGACCCACGGCAGGCACACAGC
AACGACCCCTTCCCCGCCCCTCTCCCGGCCGGCCTCCGCCCCGCAGCCAGCGCGGGGCCACCCTCTCCGGCCCTTCCCCCAGCTGTCGGC
GTCTCGCCCTGCGCCCCGGCCGGGGCCCCACACACAATGGACGAGCTTGCCGGAGGCGGTGGTGGCGGCCCGGGGATGGCGGCCCCTCCC
CGGCAGCAGCAGGGACCTGGGGGGAACCTGGGCCTTTCGCCCGGGGGGAACGGAGCGGCGGGCGGCGGGGGTCCTCCGGCCTCCGAGGGA
GCGGGTCCCGCGGCAGGCCCCGAGCTGTCCCGGCCGCAGCAGTACACTATCCCGGGGATACTGCACTACATCCAGCACGAGTGGGCTCGG
TTCGAGATGGAGCGGGCGCACTGGGAGGTGGAACGGGCCGAACTGCAGTTCCCTGAATGTGGTTTCTACGGAATGTATGATAAGATCCTG
CTTTTTCGCCATGACCCTACCTCTGAAAACATCCTTCAGCTGGTGAAAGCGGCCAGTGATATCCAGGAAGGCGATCTTATTGAAGTGGTC
TTGTCAGCTTCCGCCACCTTTGAAGACTTTCAGATTCGTCCCCACGCTCTCTTTGTTCATTCATACAGAGCTCCAGCTTTCTGTGATCAC
TGTGGAGAAATGCTGTGGGGGCTGGTACGTCAAGGTCTTAAATGTGAAGGGTGTGGTCTGAATTACCATAAGAGATGTGCATTTAAAATA
CCCAACAATTGCAGCGGTGTGAGGCGGAGAAGGCTCTCAAACGTTTCCCTCACTGGGGTCAGCACCATCCGCACATCATCTGCTGAACTC
TCTACAAGTGCCCCTGATGAGCCCCTTCTGTCTCCTGTGAGTCCTGGCTTTGAGCAAAAATCACCATCAGAGTCGTTTATTGGTCGAGAG
AAGAGGTCAAATTCTCAATCATACATTGGACGACCAATTCACCTTGACAAGATTTTGATGTCTAAAGTTAAAGTGCCGCACACATTTGTC
ATCCACTCCTACACCCGGCCCACAGTGTGCCAGTACTGCAAGAAGCTTCTGAAGGGGCTTTTCAGGCAGGGCTTGCAGTGCAAAGATTGC
AGATTCAACTGCCATAAACGTTGTGCACCGAAAGTACCAAACAACTGCCTTGGCGAAGTGACCATTAATGGAGATTTGCTTAGCCCTGGG
GCAGAGTCTGATGTGGTCATGGAAGAAGGGAGTGATGACAATGATAGTGAAAGGAACAGTGGGCTCATGGATGATATGGAAGAAGCAATG
GTCCAAGATGCAGAGATGGCAATGGCAGAGTGCCAGAACGACAGTGGCGAGATGCAAGATCCAGACCCAGACCACGAGGACGCCAACAGA
ACCATCAGTCCATCAACAAGCAACAATATCCCACTCATGAGGGTAGTGCAGTCTGTCAAACACACGAAGAGGAAAAGCAGCACAGTCATG
AAAGAAGGATGGATGGTCCACTACACCAGCAAGGACACGCTGCGGAAACGGCACTATTGGAGATTGGATAGCAAATGTATTACCCTCTTT
CAGAATGACACAGGAAGCAGGTACTACAAGGAAATTCCTTTATCTGAAATTTTGTCTCTGGAACCAGTAAAAACTTCAGCTTTAATTCCT
AATGGGGCCAATCCTCATTGTTTCGAAATCACTACGGCAAATGTAGTGTATTATGTGGGAGAAAATGTGGTCAATCCTTCCAGCCCATCA
CCAAATAACAGTGTTCTCACCAGTGGCGTTGGTGCAGATGTGGCCAGGATGTGGGAGATAGCCATCCAGCATGCCCTTATGCCCGTCATT
CCCAAGGGCTCCTCCGTGGGTACAGGAACCAACTTGCACAGAGATATCTCTGTGAGTATTTCAGTATCAAATTGCCAGATTCAAGAAAAT
GTGGACATCAGCACAGTATATCAGATTTTTCCTGATGAAGTACTGGGTTCTGGACAGTTTGGAATTGTTTATGGAGGAAAACATCGTAAA
ACAGGAAGAGATGTAGCTATTAAAATCATTGACAAATTACGATTTCCAACAAAACAAGAAAGCCAGCTTCGTAATGAGGTTGCAATTCTA
CAGAACCTTCATCACCCTGGTGTTGTAAATTTGGAGTGTATGTTTGAGACGCCTGAAAGAGTGTTTGTTGTTATGGAAAAACTCCATGGA
GACATGCTGGAAATGATCTTGTCAAGTGAAAAGGGCAGGTTGCCAGAGCACATAACGAAGTTTTTAATTACTCAGATACTCGTGGCTTTG
CGGCACCTTCATTTTAAAAATATCGTTCACTGTGACCTCAAACCAGAAAATGTGTTGCTAGCCTCAGCTGATCCTTTTCCTCAGGTGAAA
CTTTGTGATTTTGGTTTTGCCCGGATCATTGGAGAGAAGTCTTTCCGGAGGTCAGTGGTGGGTACCCCCGCTTACCTGGCTCCTGAGGTC
CTAAGGAACAAGGGCTACAATCGCTCTCTAGACATGTGGTCTGTTGGGGTCATCATCTATGTAAGCCTAAGCGGCACATTCCCATTTAAT
GAAGATGAAGACATACACGACCAAATTCAGAATGCAGCTTTCATGTATCCACCAAATCCCTGGAAGGAAATATCTCATGAAGCCATTGAT
CTTATCAACAATTTGCTGCAAGTAAAAATGAGAAAGCGCTACAGTGTGGATAAGACCTTGAGCCACCCTTGGCTACAGGACTATCAGACC
TGGTTAGATTTGCGAGAGCTGGAATGCAAAATCGGGGAGCGCTACATCACCCATGAAAGTGATGACCTGAGGTGGGAGAAGTATGCAGGC
GAGCAGGGGCTGCAGTACCCCACACACCTGATCAATCCAAGTGCTAGCCACAGTGACACTCCTGAGACTGAAGAAACAGAAATGAAAGCC
CTCGGTGAGCGTGTCAGCATCCTCTGAGTTCCATCTCCTATAATCTGTCAAAACACTGTGGAACTAATAAATACATACGGTCAGGTTTAA
CATTTGCCTTGCAGAACTGCCATTATTTTCTGTCAGATGAGAACAAAGCTGTTAAACTGTTAGCACTGTTGATGTATCTGAGTTGCCAAG
ACAAATCAACAGAAGCATTTGTATTTTGTGTGACCAACTGTGTTGTATTAACAAAAGTTCCCTGAAACACGAAACTTGTTATTGTGAATG

>87723_87723_2_STRN3-PRKD1_STRN3_chr14_31495110_ENST00000355683_PRKD1_chr14_30194880_ENST00000415220_length(amino acids)=926AA_BP=92
MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQYTIPGILHYIQHEWARFEMERAHWEVER
AELQFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQG
LKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLSPVSPGFEQKSPSESFIGREKRSNSQSYIGRP
IHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSD
DNDSERNSGLMDDMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKD
TLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGA
DVARMWEIAIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDK
LRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCD
LKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNA
AFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLIN

--------------------------------------------------------------
>87723_87723_3_STRN3-PRKD1_STRN3_chr14_31495110_ENST00000357479_PRKD1_chr14_30194880_ENST00000331968_length(transcript)=3711nt_BP=479nt
GGCAGATGGAGGAGGGATTGTAATGGCGGCAGCCGGCAGCTCCCTGCTCTGACCCACGGCAGGCACACAGCAACGACCCCTTCCCCGCCC
CTCTCCCGGCCGGCCTCCGCCCCGCAGCCAGCGCGGGGCCACCCTCTCCGGCCCTTCCCCCAGCTGTCGGCGTCTCGCCCTGCGCCCCGG
CCGGGGCCCCACACACAATGGACGAGCTTGCCGGAGGCGGTGGTGGCGGCCCGGGGATGGCGGCCCCTCCCCGGCAGCAGCAGGGACCTG
GGGGGAACCTGGGCCTTTCGCCCGGGGGGAACGGAGCGGCGGGCGGCGGGGGTCCTCCGGCCTCCGAGGGAGCGGGTCCCGCGGCAGGCC
CCGAGCTGTCCCGGCCGCAGCAGTACACTATCCCGGGGATACTGCACTACATCCAGCACGAGTGGGCTCGGTTCGAGATGGAGCGGGCGC
ACTGGGAGGTGGAACGGGCCGAACTGCAGTTCCCTGAATGTGGTTTCTACGGAATGTATGATAAGATCCTGCTTTTTCGCCATGACCCTA
CCTCTGAAAACATCCTTCAGCTGGTGAAAGCGGCCAGTGATATCCAGGAAGGCGATCTTATTGAAGTGGTCTTGTCAGCTTCCGCCACCT
TTGAAGACTTTCAGATTCGTCCCCACGCTCTCTTTGTTCATTCATACAGAGCTCCAGCTTTCTGTGATCACTGTGGAGAAATGCTGTGGG
GGCTGGTACGTCAAGGTCTTAAATGTGAAGGGTGTGGTCTGAATTACCATAAGAGATGTGCATTTAAAATACCCAACAATTGCAGCGGTG
TGAGGCGGAGAAGGCTCTCAAACGTTTCCCTCACTGGGGTCAGCACCATCCGCACATCATCTGCTGAACTCTCTACAAGTGCCCCTGATG
AGCCCCTTCTGCAAAAATCACCATCAGAGTCGTTTATTGGTCGAGAGAAGAGGTCAAATTCTCAATCATACATTGGACGACCAATTCACC
TTGACAAGATTTTGATGTCTAAAGTTAAAGTGCCGCACACATTTGTCATCCACTCCTACACCCGGCCCACAGTGTGCCAGTACTGCAAGA
AGCTTCTGAAGGGGCTTTTCAGGCAGGGCTTGCAGTGCAAAGATTGCAGATTCAACTGCCATAAACGTTGTGCACCGAAAGTACCAAACA
ACTGCCTTGGCGAAGTGACCATTAATGGAGATTTGCTTAGCCCTGGGGCAGAGTCTGATGTGGTCATGGAAGAAGGGAGTGATGACAATG
ATAGTGAAAGGAACAGTGGGCTCATGGATGATATGGAAGAAGCAATGGTCCAAGATGCAGAGATGGCAATGGCAGAGTGCCAGAACGACA
GTGGCGAGATGCAAGATCCAGACCCAGACCACGAGGACGCCAACAGAACCATCAGTCCATCAACAAGCAACAATATCCCACTCATGAGGG
TAGTGCAGTCTGTCAAACACACGAAGAGGAAAAGCAGCACAGTCATGAAAGAAGGATGGATGGTCCACTACACCAGCAAGGACACGCTGC
GGAAACGGCACTATTGGAGATTGGATAGCAAATGTATTACCCTCTTTCAGAATGACACAGGAAGCAGGTACTACAAGGAAATTCCTTTAT
CTGAAATTTTGTCTCTGGAACCAGTAAAAACTTCAGCTTTAATTCCTAATGGGGCCAATCCTCATTGTTTCGAAATCACTACGGCAAATG
TAGTGTATTATGTGGGAGAAAATGTGGTCAATCCTTCCAGCCCATCACCAAATAACAGTGTTCTCACCAGTGGCGTTGGTGCAGATGTGG
CCAGGATGTGGGAGATAGCCATCCAGCATGCCCTTATGCCCGTCATTCCCAAGGGCTCCTCCGTGGGTACAGGAACCAACTTGCACAGAG
ATATCTCTGTGAGTATTTCAGTATCAAATTGCCAGATTCAAGAAAATGTGGACATCAGCACAGTATATCAGATTTTTCCTGATGAAGTAC
TGGGTTCTGGACAGTTTGGAATTGTTTATGGAGGAAAACATCGTAAAACAGGAAGAGATGTAGCTATTAAAATCATTGACAAATTACGAT
TTCCAACAAAACAAGAAAGCCAGCTTCGTAATGAGGTTGCAATTCTACAGAACCTTCATCACCCTGGTGTTGTAAATTTGGAGTGTATGT
TTGAGACGCCTGAAAGAGTGTTTGTTGTTATGGAAAAACTCCATGGAGACATGCTGGAAATGATCTTGTCAAGTGAAAAGGGCAGGTTGC
CAGAGCACATAACGAAGTTTTTAATTACTCAGATACTCGTGGCTTTGCGGCACCTTCATTTTAAAAATATCGTTCACTGTGACCTCAAAC
CAGAAAATGTGTTGCTAGCCTCAGCTGATCCTTTTCCTCAGGTGAAACTTTGTGATTTTGGTTTTGCCCGGATCATTGGAGAGAAGTCTT
TCCGGAGGTCAGTGGTGGGTACCCCCGCTTACCTGGCTCCTGAGGTCCTAAGGAACAAGGGCTACAATCGCTCTCTAGACATGTGGTCTG
TTGGGGTCATCATCTATGTAAGCCTAAGCGGCACATTCCCATTTAATGAAGATGAAGACATACACGACCAAATTCAGAATGCAGCTTTCA
TGTATCCACCAAATCCCTGGAAGGAAATATCTCATGAAGCCATTGATCTTATCAACAATTTGCTGCAAGTAAAAATGAGAAAGCGCTACA
GTGTGGATAAGACCTTGAGCCACCCTTGGCTACAGGACTATCAGACCTGGTTAGATTTGCGAGAGCTGGAATGCAAAATCGGGGAGCGCT
ACATCACCCATGAAAGTGATGACCTGAGGTGGGAGAAGTATGCAGGCGAGCAGGGGCTGCAGTACCCCACACACCTGATCAATCCAAGTG
CTAGCCACAGTGACACTCCTGAGACTGAAGAAACAGAAATGAAAGCCCTCGGTGAGCGTGTCAGCATCCTCTGAGTTCCATCTCCTATAA
TCTGTCAAAACACTGTGGAACTAATAAATACATACGGTCAGGTTTAACATTTGCCTTGCAGAACTGCCATTATTTTCTGTCAGATGAGAA
CAAAGCTGTTAAACTGTTAGCACTGTTGATGTATCTGAGTTGCCAAGACAAATCAACAGAAGCATTTGTATTTTGTGTGACCAACTGTGT
TGTATTAACAAAAGTTCCCTGAAACACGAAACTTGTTATTGTGAATGATTCATGTTATATTTAATGCATTAAACCTGTCTCCACTGTGCC
TTTGCAAATCAGTGTTTTTCTTACTGGAGCTTCATTTTGGTAAGAGACAGAATGTATCTGTGAAGTAGTTCTGTTTGGTGTGTCCCATTG
GTGTTGTCATTGTAAACAAACTCTTGAAGAGTCGATTATTTCCAGTGTTCTATGAACAACTCCAAAACCCATGTGGGAAAAAAATGAATG
AGGAGGGTAGGGAATAAAATCCTAAGACACAAATGCATGAACAAGTTTTAATGTATAGTTTTGAATCCTTTGCCTGCCTGGTGTGCCTCA
GTATATTTAAACTCAAGACAATGCACCTAGCTGTGCAAGACCTAGTGCTCTTAAGCCTAAATGCCTTAGAAATGTAAACTGCCATATATA
ACAGATACATTTCCCTCTTTCTTATAATACTCTGTTGTACTATGGAAAATCAGCTGCTCAGCAACCTTTCACCTTTGTGTATTTTTCAAT

>87723_87723_3_STRN3-PRKD1_STRN3_chr14_31495110_ENST00000357479_PRKD1_chr14_30194880_ENST00000331968_length(amino acids)=918AA_BP=92
MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQYTIPGILHYIQHEWARFEMERAHWEVER
AELQFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQG
LKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLQKSPSESFIGREKRSNSQSYIGRPIHLDKILM
SKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSDDNDSERNS
GLMDDMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKDTLRKRHYW
RLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGADVARMWEI
AIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDKLRFPTKQE
SQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCDLKPENVLL
ASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNAAFMYPPNP
WKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLINPSASHSDT

--------------------------------------------------------------
>87723_87723_4_STRN3-PRKD1_STRN3_chr14_31495110_ENST00000357479_PRKD1_chr14_30194880_ENST00000415220_length(transcript)=3274nt_BP=479nt
GGCAGATGGAGGAGGGATTGTAATGGCGGCAGCCGGCAGCTCCCTGCTCTGACCCACGGCAGGCACACAGCAACGACCCCTTCCCCGCCC
CTCTCCCGGCCGGCCTCCGCCCCGCAGCCAGCGCGGGGCCACCCTCTCCGGCCCTTCCCCCAGCTGTCGGCGTCTCGCCCTGCGCCCCGG
CCGGGGCCCCACACACAATGGACGAGCTTGCCGGAGGCGGTGGTGGCGGCCCGGGGATGGCGGCCCCTCCCCGGCAGCAGCAGGGACCTG
GGGGGAACCTGGGCCTTTCGCCCGGGGGGAACGGAGCGGCGGGCGGCGGGGGTCCTCCGGCCTCCGAGGGAGCGGGTCCCGCGGCAGGCC
CCGAGCTGTCCCGGCCGCAGCAGTACACTATCCCGGGGATACTGCACTACATCCAGCACGAGTGGGCTCGGTTCGAGATGGAGCGGGCGC
ACTGGGAGGTGGAACGGGCCGAACTGCAGTTCCCTGAATGTGGTTTCTACGGAATGTATGATAAGATCCTGCTTTTTCGCCATGACCCTA
CCTCTGAAAACATCCTTCAGCTGGTGAAAGCGGCCAGTGATATCCAGGAAGGCGATCTTATTGAAGTGGTCTTGTCAGCTTCCGCCACCT
TTGAAGACTTTCAGATTCGTCCCCACGCTCTCTTTGTTCATTCATACAGAGCTCCAGCTTTCTGTGATCACTGTGGAGAAATGCTGTGGG
GGCTGGTACGTCAAGGTCTTAAATGTGAAGGGTGTGGTCTGAATTACCATAAGAGATGTGCATTTAAAATACCCAACAATTGCAGCGGTG
TGAGGCGGAGAAGGCTCTCAAACGTTTCCCTCACTGGGGTCAGCACCATCCGCACATCATCTGCTGAACTCTCTACAAGTGCCCCTGATG
AGCCCCTTCTGTCTCCTGTGAGTCCTGGCTTTGAGCAAAAATCACCATCAGAGTCGTTTATTGGTCGAGAGAAGAGGTCAAATTCTCAAT
CATACATTGGACGACCAATTCACCTTGACAAGATTTTGATGTCTAAAGTTAAAGTGCCGCACACATTTGTCATCCACTCCTACACCCGGC
CCACAGTGTGCCAGTACTGCAAGAAGCTTCTGAAGGGGCTTTTCAGGCAGGGCTTGCAGTGCAAAGATTGCAGATTCAACTGCCATAAAC
GTTGTGCACCGAAAGTACCAAACAACTGCCTTGGCGAAGTGACCATTAATGGAGATTTGCTTAGCCCTGGGGCAGAGTCTGATGTGGTCA
TGGAAGAAGGGAGTGATGACAATGATAGTGAAAGGAACAGTGGGCTCATGGATGATATGGAAGAAGCAATGGTCCAAGATGCAGAGATGG
CAATGGCAGAGTGCCAGAACGACAGTGGCGAGATGCAAGATCCAGACCCAGACCACGAGGACGCCAACAGAACCATCAGTCCATCAACAA
GCAACAATATCCCACTCATGAGGGTAGTGCAGTCTGTCAAACACACGAAGAGGAAAAGCAGCACAGTCATGAAAGAAGGATGGATGGTCC
ACTACACCAGCAAGGACACGCTGCGGAAACGGCACTATTGGAGATTGGATAGCAAATGTATTACCCTCTTTCAGAATGACACAGGAAGCA
GGTACTACAAGGAAATTCCTTTATCTGAAATTTTGTCTCTGGAACCAGTAAAAACTTCAGCTTTAATTCCTAATGGGGCCAATCCTCATT
GTTTCGAAATCACTACGGCAAATGTAGTGTATTATGTGGGAGAAAATGTGGTCAATCCTTCCAGCCCATCACCAAATAACAGTGTTCTCA
CCAGTGGCGTTGGTGCAGATGTGGCCAGGATGTGGGAGATAGCCATCCAGCATGCCCTTATGCCCGTCATTCCCAAGGGCTCCTCCGTGG
GTACAGGAACCAACTTGCACAGAGATATCTCTGTGAGTATTTCAGTATCAAATTGCCAGATTCAAGAAAATGTGGACATCAGCACAGTAT
ATCAGATTTTTCCTGATGAAGTACTGGGTTCTGGACAGTTTGGAATTGTTTATGGAGGAAAACATCGTAAAACAGGAAGAGATGTAGCTA
TTAAAATCATTGACAAATTACGATTTCCAACAAAACAAGAAAGCCAGCTTCGTAATGAGGTTGCAATTCTACAGAACCTTCATCACCCTG
GTGTTGTAAATTTGGAGTGTATGTTTGAGACGCCTGAAAGAGTGTTTGTTGTTATGGAAAAACTCCATGGAGACATGCTGGAAATGATCT
TGTCAAGTGAAAAGGGCAGGTTGCCAGAGCACATAACGAAGTTTTTAATTACTCAGATACTCGTGGCTTTGCGGCACCTTCATTTTAAAA
ATATCGTTCACTGTGACCTCAAACCAGAAAATGTGTTGCTAGCCTCAGCTGATCCTTTTCCTCAGGTGAAACTTTGTGATTTTGGTTTTG
CCCGGATCATTGGAGAGAAGTCTTTCCGGAGGTCAGTGGTGGGTACCCCCGCTTACCTGGCTCCTGAGGTCCTAAGGAACAAGGGCTACA
ATCGCTCTCTAGACATGTGGTCTGTTGGGGTCATCATCTATGTAAGCCTAAGCGGCACATTCCCATTTAATGAAGATGAAGACATACACG
ACCAAATTCAGAATGCAGCTTTCATGTATCCACCAAATCCCTGGAAGGAAATATCTCATGAAGCCATTGATCTTATCAACAATTTGCTGC
AAGTAAAAATGAGAAAGCGCTACAGTGTGGATAAGACCTTGAGCCACCCTTGGCTACAGGACTATCAGACCTGGTTAGATTTGCGAGAGC
TGGAATGCAAAATCGGGGAGCGCTACATCACCCATGAAAGTGATGACCTGAGGTGGGAGAAGTATGCAGGCGAGCAGGGGCTGCAGTACC
CCACACACCTGATCAATCCAAGTGCTAGCCACAGTGACACTCCTGAGACTGAAGAAACAGAAATGAAAGCCCTCGGTGAGCGTGTCAGCA
TCCTCTGAGTTCCATCTCCTATAATCTGTCAAAACACTGTGGAACTAATAAATACATACGGTCAGGTTTAACATTTGCCTTGCAGAACTG
CCATTATTTTCTGTCAGATGAGAACAAAGCTGTTAAACTGTTAGCACTGTTGATGTATCTGAGTTGCCAAGACAAATCAACAGAAGCATT
TGTATTTTGTGTGACCAACTGTGTTGTATTAACAAAAGTTCCCTGAAACACGAAACTTGTTATTGTGAATGATTCATGTTATATTTAATG

>87723_87723_4_STRN3-PRKD1_STRN3_chr14_31495110_ENST00000357479_PRKD1_chr14_30194880_ENST00000415220_length(amino acids)=926AA_BP=92
MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQYTIPGILHYIQHEWARFEMERAHWEVER
AELQFPECGFYGMYDKILLFRHDPTSENILQLVKAASDIQEGDLIEVVLSASATFEDFQIRPHALFVHSYRAPAFCDHCGEMLWGLVRQG
LKCEGCGLNYHKRCAFKIPNNCSGVRRRRLSNVSLTGVSTIRTSSAELSTSAPDEPLLSPVSPGFEQKSPSESFIGREKRSNSQSYIGRP
IHLDKILMSKVKVPHTFVIHSYTRPTVCQYCKKLLKGLFRQGLQCKDCRFNCHKRCAPKVPNNCLGEVTINGDLLSPGAESDVVMEEGSD
DNDSERNSGLMDDMEEAMVQDAEMAMAECQNDSGEMQDPDPDHEDANRTISPSTSNNIPLMRVVQSVKHTKRKSSTVMKEGWMVHYTSKD
TLRKRHYWRLDSKCITLFQNDTGSRYYKEIPLSEILSLEPVKTSALIPNGANPHCFEITTANVVYYVGENVVNPSSPSPNNSVLTSGVGA
DVARMWEIAIQHALMPVIPKGSSVGTGTNLHRDISVSISVSNCQIQENVDISTVYQIFPDEVLGSGQFGIVYGGKHRKTGRDVAIKIIDK
LRFPTKQESQLRNEVAILQNLHHPGVVNLECMFETPERVFVVMEKLHGDMLEMILSSEKGRLPEHITKFLITQILVALRHLHFKNIVHCD
LKPENVLLASADPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRNKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDIHDQIQNA
AFMYPPNPWKEISHEAIDLINNLLQVKMRKRYSVDKTLSHPWLQDYQTWLDLRELECKIGERYITHESDDLRWEKYAGEQGLQYPTHLIN

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for STRN3-PRKD1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for STRN3-PRKD1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for STRN3-PRKD1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source