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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:STX8-MYO15A (FusionGDB2 ID:87857)

Fusion Gene Summary for STX8-MYO15A

Fusion gene summary

Fusion gene information	Fusion gene name: STX8-MYO15A
	Fusion gene ID: 87857
		Hgene	Tgene
	Gene symbol	STX8	MYO15A
	Gene ID	9482	51168
	Gene name	syntaxin 8	myosin XVA
	Synonyms	CARB	DFNB3\|MYO15
	Cytomap	17p13.1	17p11.2
	Type of gene	protein-coding	protein-coding
	Description	syntaxin-8CIP-1-associated regulator of cyclin B	unconventional myosin-XVmyosin-XVunconventional myosin-15
	Modification date	20200313	20200322
	UniProtAcc	.	Q9UKN7
	Ensembl transtripts involved in fusion gene	ENST00000306357, ENST00000573373, ENST00000574431,	ENST00000412324, ENST00000418233, ENST00000451725, ENST00000585180, ENST00000205890,
Fusion gene scores	* DoF score	21 X 18 X 8=3024	4 X 5 X 3=60
	# samples	23	5
	** MAII score	log2(23/3024*10)=-3.7167523732767 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: STX8 [Title/Abstract] AND MYO15A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	STX8(9479109)-MYO15A(18027797), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	STX8	GO:0045022	early endosome to late endosome transport	10564279
Hgene	STX8	GO:1903076	regulation of protein localization to plasma membrane	18570918

Fusion gene breakpoints across STX8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MYO15A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AC-A2QH-01B	STX8	chr17	9479109	-	MYO15A	chr17	18027797	+

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Fusion Gene ORF analysis for STX8-MYO15A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000306357	ENST00000412324	STX8	chr17	9479109	-	MYO15A	chr17	18027797	+
5CDS-intron	ENST00000306357	ENST00000418233	STX8	chr17	9479109	-	MYO15A	chr17	18027797	+
5CDS-intron	ENST00000306357	ENST00000451725	STX8	chr17	9479109	-	MYO15A	chr17	18027797	+
5CDS-intron	ENST00000306357	ENST00000585180	STX8	chr17	9479109	-	MYO15A	chr17	18027797	+
5UTR-3CDS	ENST00000573373	ENST00000205890	STX8	chr17	9479109	-	MYO15A	chr17	18027797	+
5UTR-3CDS	ENST00000574431	ENST00000205890	STX8	chr17	9479109	-	MYO15A	chr17	18027797	+
5UTR-intron	ENST00000573373	ENST00000412324	STX8	chr17	9479109	-	MYO15A	chr17	18027797	+
5UTR-intron	ENST00000573373	ENST00000418233	STX8	chr17	9479109	-	MYO15A	chr17	18027797	+
5UTR-intron	ENST00000573373	ENST00000451725	STX8	chr17	9479109	-	MYO15A	chr17	18027797	+
5UTR-intron	ENST00000573373	ENST00000585180	STX8	chr17	9479109	-	MYO15A	chr17	18027797	+
5UTR-intron	ENST00000574431	ENST00000412324	STX8	chr17	9479109	-	MYO15A	chr17	18027797	+
5UTR-intron	ENST00000574431	ENST00000418233	STX8	chr17	9479109	-	MYO15A	chr17	18027797	+
5UTR-intron	ENST00000574431	ENST00000451725	STX8	chr17	9479109	-	MYO15A	chr17	18027797	+
5UTR-intron	ENST00000574431	ENST00000585180	STX8	chr17	9479109	-	MYO15A	chr17	18027797	+
In-frame	ENST00000306357	ENST00000205890	STX8	chr17	9479109	-	MYO15A	chr17	18027797	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000306357

STX8

chr17

9479109

ENST00000205890

MYO15A

chr17

18027797

8361

445

421

7428

2335

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000306357	ENST00000205890	STX8	chr17	9479109	-	MYO15A	chr17	18027797	+	0.005386775	0.99461323

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Fusion Genomic Features for STX8-MYO15A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
STX8	chr17	9479108	-	MYO15A	chr17	18027796	+	7.95E-08	0.9999999
STX8	chr17	9479108	-	MYO15A	chr17	18027796	+	7.95E-08	0.9999999

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for STX8-MYO15A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:9479109/chr17:18027797)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	MYO15A Q9UKN7
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MYO15A

chr17:9479109

chr17:18027797

ENST00000205890

1323_1350

1203

3531.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MYO15A

chr17:9479109

chr17:18027797

ENST00000205890

1222_1899

1203

3531.0

Domain

Myosin motor

Tgene

MYO15A

chr17:9479109

chr17:18027797

ENST00000205890

1902_1924

1203

3531.0

Domain

IQ 1

Tgene

MYO15A

chr17:9479109

chr17:18027797

ENST00000205890

1925_1954

1203

3531.0

Domain

IQ 2

Tgene

MYO15A

chr17:9479109

chr17:18027797

ENST00000205890

1955_1976

1203

3531.0

Domain

IQ 3

Tgene

MYO15A

chr17:9479109

chr17:18027797

ENST00000205890

2065_2217

1203

3531.0

Domain

MyTH4 1

Tgene

MYO15A

chr17:9479109

chr17:18027797

ENST00000205890

2867_2953

1203

3531.0

Domain

SH3

Tgene

MYO15A

chr17:9479109

chr17:18027797

ENST00000205890

3050_3204

1203

3531.0

Domain

MyTH4 2

Tgene

MYO15A

chr17:9479109

chr17:18027797

ENST00000205890

3209_3530

1203

3531.0

Domain

FERM

Tgene

MYO15A

chr17:9479109

chr17:18027797

ENST00000205890

1315_1322

1203

3531.0

Nucleotide binding

ATP

Tgene

MYO15A

chr17:9479109

chr17:18027797

ENST00000205890

1792_1799

1203

3531.0

Region

Actin-binding

Tgene

MYO15A

chr17:9479109

chr17:18027797

ENST00000205890

1888_2029

1203

3531.0

Region

Note=Neck or regulatory domain

Tgene

MYO15A

chr17:9479109

chr17:18027797

ENST00000205890

2030_3530

1203

3531.0

Region

Note=Tail

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

STX8

chr17:9479109

chr17:18027797

ENST00000306357

42_65

237.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

STX8

chr17:9479109

chr17:18027797

ENST00000306357

145_207

237.0

Domain

t-SNARE coiled-coil homology

Hgene

STX8

chr17:9479109

chr17:18027797

ENST00000306357

1_215

237.0

Topological domain

Cytoplasmic

Hgene

STX8

chr17:9479109

chr17:18027797

ENST00000306357

233_236

237.0

Topological domain

Vesicular

Hgene

STX8

chr17:9479109

chr17:18027797

ENST00000306357

216_232

237.0

Transmembrane

Helical%3B Anchor for type IV membrane protein

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Fusion Gene Sequence for STX8-MYO15A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>87857_87857_1_STX8-MYO15A_STX8_chr17_9479109_ENST00000306357_MYO15A_chr17_18027797_ENST00000205890_length(transcript)=8361nt_BP=445nt
GGTATAATTTACATATCATAAAGTTAACTTAAAGTAGGTTGTAGTGAGTTTACGCAGCGTGCAAGTCTCACCGCAATCTAGTGTTTTGTT
TATTGTTTTGTTTTTGAAGCAGGATAAATTTTTAAGTAACTGCTACAGAGAGGTCTTGCAGCGCTCCCACCTTCCTGGGAAAATGCTTTG
TTTCTATTTAACAATTTTAACTGAGCTTAGCAGTTCGCGTCTCTTGGTGGGAGTAGATTGCTCCAGTGTACTGTCCGCAGGGGAGCGCTT
TGCTTTCTCTGATTATAGTTCTGAGGCCCTAGCTACTCACTTTGCAAACTCCAGGCTCCGGTCGCGCACGGGACGAACTGCGGGGAGTGA
GCCGCGCGGGCCGCCGTAGTCAGCTGCTAAGAGCAGGAAGAGTCCGAGCGGCGGGCGGAGTCTGCAGGATGGCACCGGACCCCTGATGCA
CTCCATCCGCAACCTGCCATCCATGCGGTTCCGTGAGCAGCACGGGGAGGATGGTGTGGAGGACATGACACAGCTGGAAGACCTCCAGGA
AACCACTGTGCTGTCCAACCTCAAGATTAGATTTGAACGGAACCTCATCTACACATACATTGGGAGCATCCTGGTGTCGGTGAACCCATA
CCAAATGTTTGGAATCTATGGGCCGGAGCAGGTGCAGCAGTACAACGGACGGGCCCTGGGAGAGAATCCCCCGCACCTCTTTGCTGTTGC
AAATCTCGCCTTCGCCAAAATGCTCGATGCCAAACAGAACCAGTGCATAATCATTAGTGGAGAGAGCGGCTCTGGCAAAACTGAGGCCAC
CAAGCTGATTCTGCGCTACCTGGCCGCCATGAACCAGAAACGGGAGGTCATGCAGCAGATAAAGATCCTGGAGGCAACACCCCTCTTGGA
GTCCTTCGGTAATGCCAAAACCGTCAGGAACGACAACTCCAGCCGCTTTGGGAAGTTTGTGGAAATCTTTCTGGAAGGGGGCGTGATCTC
TGGTGCCATAACCTCCCAGTACCTGCTTGAGAAATCCAGGATCGTGTTTCAGGCCAAAAACGAGAGGAATTACCACATCTTCTACGAGTT
GCTGGCCGGGTTGCCTGCCCAGCTCAGGCAGGCCTTTAGCCTGCAAGAGGCTGAGACCTACTACTATCTGAACCAGGGTGGGAACTGTGA
GATAGCAGGAAAGAGCGATGCAGATGACTTTCGCCGGCTCCTGGCTGCCATGGAGGTGTTGGGCTTCAGCAGTGAGGACCAGGACAGCAT
CTTCCGCATCCTGGCCTCCATCCTGCACCTGGGCAACGTCTACTTTGAGAAGTATGAGACGGATGCACAGGAGGTGGCCTCAGTGGTGAG
TGCCCGAGAGATCCAGGCCGTGGCAGAGCTGCTGCAGATCTCCCCTGAGGGCCTGCAGAAGGCCATCACCTTCAAAGTGACCGAGACAAT
GCGAGAGAAGATCTTCACGCCCCTAACTGTGGAGAGCGCTGTGGATGCCAGGGACGCCATCGCCAAGGTCTTGTATGCACTGCTGTTCAG
CTGGCTCATCACCAGGGTCAACGCGCTGGTGTCCCCAAGGCAGGACACACTGTCCATCGCCATCCTGGACATCTATGGTTTCGAGGACCT
GAGCTTCAACAGCTTTGAGCAGCTGTGTATTAACTACGCAAACGAGAACCTTCAGTACCTTTTCAACAAGATCGTCTTCCAGGAGGAGCA
GGAGGAGTACATCCGTGAGCAGATAGACTGGCAGGAGATCACCTTTGCTGACAACCAGCCCTGCATCAACCTCATCTCACTGAAGCCTTA
TGGCATCCTGCGGATCCTTGACGACCAGTGTTGCTTTCCCCAGGCTACAGACCACACCTTCCTACAGAAGTGCCACTACCATCATGGCGC
CAACCCGCTCTATTCCAAACCCAAGATGCCGCTGCCTGAGTTCACCATCAAGCACTATGCAGGCAAGGTCACCTACCAGGTGCACAAGTT
CCTGGACAAGAACCACGACCAAGTGCGCCAGGATGTGCTGGACCTGTTCGTACGGAGCCGGACACGGGTGGTGGCACACCTCTTCTCCAG
CCATGCCCCACAGGCTGCCCCTCAGCGCCTGGGCAAGAGCAGCTCCGTCACTCGGCTCTACAAGGCGCACACTGTGGCCGCCAAGTTCCA
GCAGTCACTCCTGGATCTGGTGGAAAAGATGGAGAGGTGCAACCCCTTGTTCATGCGTTGCCTGAAGCCCAACCACAAGAAGGAGCCAGG
TCTCTTTGAGCCAGATGTGGTAATGGCACAATTACGCTATTCAGGGGTGCTGGAGACCGTGAGGATCCGCAAGGAGGGATTTCCAGTGCG
CCTGCCTTTCCAGGGGTTCATCGACAGGTACTGCTGTCTAGTGGCCCTCAAGCATGACCTGCCGGCTAATGGGGACATGTGTGTGTCAGT
GCTGAGTCGCCTGTGCAAAGTCATGCCAAACATGTACCGTGTTGGGGTCAGCAAGCTGTTCCTTAAGGAACACCTATACCAGCTGCTGGA
GAGTATGCGAGAGCATGTCCTGAATCTGGCAGCCCTCACTCTGCAGCGCTGCCTCCGTGGCTTCTTCATTAAGCGGCGATTCCGCTCTCT
GCGCCACAAGATCATCCTGCTGCAAAGCCGGGCCCGTGGCTACCTTGCCAGGCAACGCTATCAGCAGATGAGGAGGAGTCTGGTGAAGTT
CCGGTCCCTGGTACACGCATACGTGAGCCGCCGACGCTATCTCAAGCTGAGGGCAGAGTGGAGGTGCCAGGTGGAGGGGGCGCTGCTGTG
GGAGCAGGAGGAGCTGAGCAAGCGGGAGGTAGTCGCTGTGGGGCACCTGGAGGTACCGGCTGAGCTGGCTGGGCTCTTGCAAGCAGTGGC
AGGCCTCGGGCTGGCCCAGGTGCCTCAGGTGGCCCCTGTGAGGACTCCTCGACTCCAGGCTGAGCCCCGTGTCACACTGCCCCTGGACAT
CAACAACTATCCTATGGCCAAGTTTGTCCAGTGCCACTTCAAGGAACCTGCCTTTGGGATGCTGACAGTGCCCCTGAGGACACCCCTCAC
GCAGCTGCCAGCCGAGCACCATGCAGAAGCCGTGAGCATCTTCAAGCTGATCCTGCGCTTCATGGGCGACCCCCACCTGCATGGTGCCCG
GGAGAACATCTTCGGGAACTACATCGTGCAGAAGGGGCTGGCGGTGCCTGAGCTGCGGGATGAGATCCTGGCACAGCTGGCCAATCAGGT
GTGGCACAATCACAATGCCCACAATGCTGAGCGGGGCTGGCTGCTGCTGGCCGCCTGCCTCAGTGGCTTTGCACCTTCCCCGTGCTTCAA
CAAGTACCTTCTCAAGTTTGTGTCTGATTATGGGCGGAATGGCTTCCAGGCTGTGTGTCAGCACCGCCTCATGCAGGCCATGGGCCGGGC
CCAACAGCAGGGCTCGGGGGCTGCCCGCACCTTACCCCCGACCCAGCTCGAGTGGACAGCGACCTATGAGAAGGCCAGCATGGCGCTGGA
CGTGGGCTGCTTCAATGGTGACCAGTTCTCCTGCCCGGTGCACTCCTGGAGTACGGGGGAAGAGGTGGCTGGAGACATTCTGAGGCACAG
GGGGCTGGCAGATGGCTGGCGCGGCTGGACCGTGGCCATGAAGAATGGTGTCCAGTGGGCAGAGCTGGCTGGCCACGACTACGTGTTAGA
CCTGGTGTCGGACCTGGAGCTGCTCAGGGACTTCCCTCGACAGAAGTCCTACTTCATTGTGGGCACAGAGGGGCCTGCAGCCAGCAGGGG
AGGCCCCAAAGTGGTGTTTGGGAACAGCTGGGACTCGGATGAGGACATGTCCACTAGACCCCAGCCCCAGGAGCACATGCCCAAAGTACT
TGACTCTGATGGGTACAGCAGCCACAATCAGGACGGTACAAATGGGGAGACTGAGGCCCAAAGAGGGACAGCAACCCACCAAGAGTCAGA
CAGTCTTGGAGAGCCTGCTGTGCCCCACAAGGGGCTGGACTGCTACCTGGATAGCCTCTTTGACCCTGTGCTGTCCTACGGGGATGCGGA
CCTGGAGAAGCCAACAGCCATTGCCTACCGCATGAAAGGGGGAGGCCAGCCCGGTGGAGGCAGCAGTAGTGGTACTGAAGACACCCCCAG
GAGACCCCCAGAGCCAAAGCCAATCCCAGGCCTGGATGCCTCCACATTGGCTCTGCAGCAAGCCTTCATCCACAAACAGGCCGTGCTGCT
GGCCCGGGAGATGACCCTGCAGGCCACGGCACTCCAGCAGCAGCCCCTGAGTGCTGCCCTGAGATCCTTGCCCGCAGAGAAACCCCCAGC
ACCAGAGGCACAGCCGACGTCTGTAGGCACCGGTCCCCCTGCCAAACCCGTGCTCCTGCGTGCCACTCCAAAGCCCTTGGCCCCAGCCCC
TCTGGCCAAGGCTCCAAGGCTCCCCATCAAGCCTGTGGCTGCCCCTGTTCTAGCTCAGGATCAGGCTTCTCCAGAAACCACTTCACCCTC
CCCAGAGCTGGTCCGGTACTCTACGCTCAACTCTGAGCACTTCCCACAGCCCACACAGCAGATCAAGAATATTGTCAGGCAGTACCAGCA
GCCGTTCCGGGGAGGCCGGCCTGAGGCCCTCAGGAAGGATGGCGGGAAAGTGTTCATGAAGCGGCCAGACCCTCATGAGGAGGCCCTGAT
GATCCTGAAAGGGCAGATGACCCACCTGGCAGCTGCACCTGGCACCCAGGTGTCCAGAGAGGCCGTGGCCCTGGTGAAGCCGGTGACCAG
TGCACCAAGGCCATCCATGGCACCCACTTCAGCTCTGCCCTCGCGATCGCTGGAGCCCCCTGAGGAACTCACGCAGACGCGGCTGCACCG
CCTCATCAATCCCAACTTCTACGGCTATCAGGACGCCCCCTGGAAGATCTTCCTGCGCAAAGAGGTGTTTTACCCCAAGGACAGCTACAG
CCATCCTGTGCAGCTTGACCTCCTGTTCCGGCAGATCCTGCACGACACGCTCTCCGAGGCCTGCCTTCGCATCTCTGAGGATGAGAGGCT
CAGGATGAAGGCCTTGTTTGCCCAGAACCAGCTGGACACACAGAAGCCTCTGGTAACGGAAAGCGTGAAGCGGGCCGTGGTCAGCACTGC
ACGAGACACCTGGGAGGTCTACTTCTCCCGCATCTTCCCCGCCACGGGCAGCGTGGGCACTGGTGTGCAGCTCCTAGCTGTGTCCCACGT
GGGCATCAAACTCCTGAGGATGGTCAAGGGTGGCCAGGAGGCCGGCGGGCAGCTGCGGGTCCTGCGTGCATACAGCTTTGCAGATATCCT
GTTTGTGACCATGCCCTCCCAGAACATGCTGGAGTTCAACCTGGCCAGTGAGAAGGTCATCCTCTTCTCAGCCCGAGCGCACCAGGTCAA
GACCCTGGTAGATGACTTCATCTTGGAGCTGAAGAAGGACTCTGACTACGTGGTCGCTGTGAGGAACTTCCTGCCTGAGGACCCTGCGCT
GCTGGCTTTCCACAAGGGTGACATCATACACCTGCAGCCCCTAGAGCCACCTCGAGTGGGCTACAGTGCTGGCTGCGTGGTTCGCAGGAA
GGTGGTGTACCTGGAGGAGCTGCGACGTAGAGGCCCCGACTTTGGCTGGAGGTTCGGGACCATCCACGGGCGCGTGGGCCGCTTCCCTTC
GGAGCTGGTGCAGCCCGCTGCTGCCCCCGACTTCCTGCAGCTGCCAACGGAGCCAGGCCGCGGCCGAGCAGCCGCCGTGGCCGCTGCTGT
GGCCTCTGCAGCCGCTGCACAGGAGGTGGGCCGCAGGAGAGAGGGTCCCCCAGTCAGGGCCCGCTCTGCTGACCATGGGGAGGACGCCCT
GGCGCTCCCACCCTACACAATGCTCGAGTTTGCCCAGAAGTATTTCCGAGACCCTCAGAGGAGACCCCAGGATGGCCTCAGGCTGAAATC
CAAGGAGCCTCGGGAGTCCAGAACCTTGGAGGACATGCTTTGCTTCACCAAGACTCCCCTCCAGGAATCCCTCATCGAACTCAGCGACAG
CAGCCTCAGCAAGATGGCCACCGACATGTTCCTAGCTGTAATGAGGTTCATGGGGGATGCCCCACTGAAGGGCCAGAGTGACCTGGACGT
GCTTTGTAACCTCCTGAAGCTGTGCGGGGACCATGAGGTCATGCGGGATGAATGTTACTGCCAAGTTGTGAAGCAGATCACAGACAATAC
CAGCTCCAAGCAGGACAGCTGCCAGCGAGGCTGGAGGCTGCTGTATATCGTGACCGCCTACCACAGCTGCTCTGAGGTCCTCCACCCACA
CCTCACTCGCTTCCTCCAAGACGTGAGCCGGACCCCAGGCCTGCCCTTTCAGGGGATCGCCAAGGCCTGCGAGCAGAACCTGCAGAAAAC
CTTGCGCTTCGGAGGTCGTCTGGAGCTCCCCAGCAGCATAGAGCTTCGGGCCATGTTGGCAGGCCGCAGTTCCAAGAGGCAACTCTTTCT
TCTTCCTGGAGGCCTTGAACGCCATCTCAAAATCAAAACATGCACTGTGGCCCTGGACGTGGTGGAAGAGATATGTGCTGAGATGGCTCT
GACACGCCCTGAGGCCTTCAATGAATATGTTATCTTCGTTGTCACCAACCGTGGCCAGCATGTGTGCCCACTCAGTCGCCGTGCTTACAT
CCTGGATGTGGCCTCAGAGATGGAGCAGGTGGACGGCGGCTACATGCTCTGGTTCCGGCGTGTGCTCTGGGATCAGCCACTCAAGTTCGA
GAATGAGCTATATGTGACCATGCACTACAACCAGGTCCTGCCTGACTACCTGAAGGGACTCTTCAGCAGTGTGCCGGCCAGCCGGCCCAG
CGAGCAGCTGCTGCAGCAGGTGTCCAAGCTGGCTTCACTGCAGCATCGCGCCAAGGACCACTTCTACCTGCCGAGCGTGCGGGAAGTCCA
GGAGTACATCCCAGCCCAGCTCTACCGTACAACGGCAGGCTCGACCTGGCTCAACCTGGTCAGCCAGCACCGGCAGCAGACACAGGCGCT
CAGCCCCCACCAGGCCCGTGCCCAGTTTCTGGGCCTCCTCAGCGCCTTACCTATGTTCGGCTCCTCCTTCTTCTTCATCCAGAGCTGCAG
CAACATTGCTGTGCCAGCCCCTTGCATCCTTGCCATCAACCACAATGGCCTCAACTTTCTCAGCACAGAGACTCATGAATTGATGGTGAA
GTTCCCCCTGAAGGAGATCCAGTCGACGCGGACCCAGCGGCCCACGGCCAACTCCAGCTACCCCTATGTGGAGATTGCGCTGGGGGACGT
GGCGGCCCAGCGCACCTTGCAGCTGCAGCTGGAGCAGGGACTGGAACTGTGTCGTGTGGTGGCCGTGCACGTGGAGAACCTGCTCAGTGC
CCATGAGAAGCGGCTCACATTGCCCCCCAGCGAGATCACCCTGCTCTGACCCAGCCCCCAGCCCTCCAGTACCTTCTGCCAGAAGACTCA
CTGTGTGGCCTCAGAGAAATCACTGAACCTCTCAGGATCAATGACCCCTGTAAGGGGCCAGAGCCTTGGAGGACACTAAGAGGAGGCAGG
AGGAGCAACTCAAATCCCCAAGAACACAAGAAGACCCATCCTGAACTGGGATGGAATGGCAGCATGCAAACTTGGATCAGATAGCAGGAG
GAACTTTCAAAAGTCTGGCCCACTGTGCAGTGGAGCAGAAGGCAGGACCATGAGGCCTCCTGCCATGTACCCATTGCAGACCCTGCCCCT
AACTCCTGCCTATGACACAGAAGCCCCACACCAGTTGCCCAGATGAACTGGCCTCTGCCTTTGGTTTACTCAGGGTCTGATGTTGGAATC
TGCTCCAACTCCACACCCTAGCCCTTACATGTCCTCCTAAGGGGCCCCTCCTTGTGCTGCCAGTCAGCCTGGATTTCTGGTCTTTGGTTA
TTTCTGTGCAAACAAAAGGTGTGCCTGGCAGCCATTTCTCCATGGAGTTGCTAAGTGGCCGGAAAACAAGCCTGAGGGAGGAGGCAGGAG
TTGGAGTTACCTTAGGCCCCTGATTCACTGCCTATGAACAGACCATCCCCCACTCCTTGGGTATCCCCAACCCCAGACCCCCATCACTTG
ATGGGCCACACAAGTTTGAGAGTGGTACAAGGGAGAAGTTTGGGAAAAGCCTTCTTGGAAAATGGGACATTAGCATTGAGTTTTGAAAGA
TGAGTAGGAGTTTGCTAAGAATAGATGGAAGACAGCAGGATAAACATTCCAGAGAAAATCATGTTTATTCCCTGCTGTATCTTCCAGAAC

>87857_87857_1_STX8-MYO15A_STX8_chr17_9479109_ENST00000306357_MYO15A_chr17_18027797_ENST00000205890_length(amino acids)=2335AA_BP=8
MQDGTGPLMHSIRNLPSMRFREQHGEDGVEDMTQLEDLQETTVLSNLKIRFERNLIYTYIGSILVSVNPYQMFGIYGPEQVQQYNGRALG
ENPPHLFAVANLAFAKMLDAKQNQCIIISGESGSGKTEATKLILRYLAAMNQKREVMQQIKILEATPLLESFGNAKTVRNDNSSRFGKFV
EIFLEGGVISGAITSQYLLEKSRIVFQAKNERNYHIFYELLAGLPAQLRQAFSLQEAETYYYLNQGGNCEIAGKSDADDFRRLLAAMEVL
GFSSEDQDSIFRILASILHLGNVYFEKYETDAQEVASVVSAREIQAVAELLQISPEGLQKAITFKVTETMREKIFTPLTVESAVDARDAI
AKVLYALLFSWLITRVNALVSPRQDTLSIAILDIYGFEDLSFNSFEQLCINYANENLQYLFNKIVFQEEQEEYIREQIDWQEITFADNQP
CINLISLKPYGILRILDDQCCFPQATDHTFLQKCHYHHGANPLYSKPKMPLPEFTIKHYAGKVTYQVHKFLDKNHDQVRQDVLDLFVRSR
TRVVAHLFSSHAPQAAPQRLGKSSSVTRLYKAHTVAAKFQQSLLDLVEKMERCNPLFMRCLKPNHKKEPGLFEPDVVMAQLRYSGVLETV
RIRKEGFPVRLPFQGFIDRYCCLVALKHDLPANGDMCVSVLSRLCKVMPNMYRVGVSKLFLKEHLYQLLESMREHVLNLAALTLQRCLRG
FFIKRRFRSLRHKIILLQSRARGYLARQRYQQMRRSLVKFRSLVHAYVSRRRYLKLRAEWRCQVEGALLWEQEELSKREVVAVGHLEVPA
ELAGLLQAVAGLGLAQVPQVAPVRTPRLQAEPRVTLPLDINNYPMAKFVQCHFKEPAFGMLTVPLRTPLTQLPAEHHAEAVSIFKLILRF
MGDPHLHGARENIFGNYIVQKGLAVPELRDEILAQLANQVWHNHNAHNAERGWLLLAACLSGFAPSPCFNKYLLKFVSDYGRNGFQAVCQ
HRLMQAMGRAQQQGSGAARTLPPTQLEWTATYEKASMALDVGCFNGDQFSCPVHSWSTGEEVAGDILRHRGLADGWRGWTVAMKNGVQWA
ELAGHDYVLDLVSDLELLRDFPRQKSYFIVGTEGPAASRGGPKVVFGNSWDSDEDMSTRPQPQEHMPKVLDSDGYSSHNQDGTNGETEAQ
RGTATHQESDSLGEPAVPHKGLDCYLDSLFDPVLSYGDADLEKPTAIAYRMKGGGQPGGGSSSGTEDTPRRPPEPKPIPGLDASTLALQQ
AFIHKQAVLLAREMTLQATALQQQPLSAALRSLPAEKPPAPEAQPTSVGTGPPAKPVLLRATPKPLAPAPLAKAPRLPIKPVAAPVLAQD
QASPETTSPSPELVRYSTLNSEHFPQPTQQIKNIVRQYQQPFRGGRPEALRKDGGKVFMKRPDPHEEALMILKGQMTHLAAAPGTQVSRE
AVALVKPVTSAPRPSMAPTSALPSRSLEPPEELTQTRLHRLINPNFYGYQDAPWKIFLRKEVFYPKDSYSHPVQLDLLFRQILHDTLSEA
CLRISEDERLRMKALFAQNQLDTQKPLVTESVKRAVVSTARDTWEVYFSRIFPATGSVGTGVQLLAVSHVGIKLLRMVKGGQEAGGQLRV
LRAYSFADILFVTMPSQNMLEFNLASEKVILFSARAHQVKTLVDDFILELKKDSDYVVAVRNFLPEDPALLAFHKGDIIHLQPLEPPRVG
YSAGCVVRRKVVYLEELRRRGPDFGWRFGTIHGRVGRFPSELVQPAAAPDFLQLPTEPGRGRAAAVAAAVASAAAAQEVGRRREGPPVRA
RSADHGEDALALPPYTMLEFAQKYFRDPQRRPQDGLRLKSKEPRESRTLEDMLCFTKTPLQESLIELSDSSLSKMATDMFLAVMRFMGDA
PLKGQSDLDVLCNLLKLCGDHEVMRDECYCQVVKQITDNTSSKQDSCQRGWRLLYIVTAYHSCSEVLHPHLTRFLQDVSRTPGLPFQGIA
KACEQNLQKTLRFGGRLELPSSIELRAMLAGRSSKRQLFLLPGGLERHLKIKTCTVALDVVEEICAEMALTRPEAFNEYVIFVVTNRGQH
VCPLSRRAYILDVASEMEQVDGGYMLWFRRVLWDQPLKFENELYVTMHYNQVLPDYLKGLFSSVPASRPSEQLLQQVSKLASLQHRAKDH
FYLPSVREVQEYIPAQLYRTTAGSTWLNLVSQHRQQTQALSPHQARAQFLGLLSALPMFGSSFFFIQSCSNIAVPAPCILAINHNGLNFL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for STX8-MYO15A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for STX8-MYO15A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for STX8-MYO15A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source