FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:STXBP2-TRIM4 (FusionGDB2 ID:87882)

Fusion Gene Summary for STXBP2-TRIM4

check button Fusion gene summary
Fusion gene informationFusion gene name: STXBP2-TRIM4
Fusion gene ID: 87882
HgeneTgene
Gene symbol

STXBP2

TRIM4

Gene ID

6813

89122

Gene namesyntaxin binding protein 2tripartite motif containing 4
SynonymsFHL5|Hunc18b|MUNC18-2|UNC18-2|UNC18B|pp10122RNF87
Cytomap

19p13.2

7q22.1

Type of geneprotein-codingprotein-coding
Descriptionsyntaxin-binding protein 2protein unc-18 homolog Bunc-18BE3 ubiquitin-protein ligase TRIM4RING finger protein 87RING-type E3 ubiquitin transferase TRIM4tripartite motif protein 4
Modification date2020032820200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000221283, ENST00000414284, 
ENST00000441779, ENST00000602355, 
ENST00000354241, ENST00000349062, 
ENST00000355947, 
Fusion gene scores* DoF score5 X 5 X 4=1003 X 3 X 3=27
# samples 54
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: STXBP2 [Title/Abstract] AND TRIM4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSTXBP2(7704693)-TRIM4(99490369), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across STXBP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TRIM4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-DD-A11C-01ASTXBP2chr19

7704693

-TRIM4chr7

99490369

-
ChimerDB4LIHCTCGA-DD-A11C-01ASTXBP2chr19

7704693

+TRIM4chr7

99490369

-
ChimerDB4LIHCTCGA-DD-A11C-01ASTXBP2chr19

7705889

+TRIM4chr7

99490369

-


Top

Fusion Gene ORF analysis for STXBP2-TRIM4

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000221283ENST00000354241STXBP2chr19

7704693

+TRIM4chr7

99490369

-
5CDS-intronENST00000221283ENST00000354241STXBP2chr19

7705889

+TRIM4chr7

99490369

-
5CDS-intronENST00000414284ENST00000354241STXBP2chr19

7704693

+TRIM4chr7

99490369

-
5CDS-intronENST00000414284ENST00000354241STXBP2chr19

7705889

+TRIM4chr7

99490369

-
5CDS-intronENST00000441779ENST00000354241STXBP2chr19

7704693

+TRIM4chr7

99490369

-
5CDS-intronENST00000441779ENST00000354241STXBP2chr19

7705889

+TRIM4chr7

99490369

-
In-frameENST00000221283ENST00000349062STXBP2chr19

7704693

+TRIM4chr7

99490369

-
In-frameENST00000221283ENST00000349062STXBP2chr19

7705889

+TRIM4chr7

99490369

-
In-frameENST00000221283ENST00000355947STXBP2chr19

7704693

+TRIM4chr7

99490369

-
In-frameENST00000221283ENST00000355947STXBP2chr19

7705889

+TRIM4chr7

99490369

-
In-frameENST00000414284ENST00000349062STXBP2chr19

7704693

+TRIM4chr7

99490369

-
In-frameENST00000414284ENST00000349062STXBP2chr19

7705889

+TRIM4chr7

99490369

-
In-frameENST00000414284ENST00000355947STXBP2chr19

7704693

+TRIM4chr7

99490369

-
In-frameENST00000414284ENST00000355947STXBP2chr19

7705889

+TRIM4chr7

99490369

-
In-frameENST00000441779ENST00000349062STXBP2chr19

7704693

+TRIM4chr7

99490369

-
In-frameENST00000441779ENST00000349062STXBP2chr19

7705889

+TRIM4chr7

99490369

-
In-frameENST00000441779ENST00000355947STXBP2chr19

7704693

+TRIM4chr7

99490369

-
In-frameENST00000441779ENST00000355947STXBP2chr19

7705889

+TRIM4chr7

99490369

-
intron-3CDSENST00000602355ENST00000349062STXBP2chr19

7704693

+TRIM4chr7

99490369

-
intron-3CDSENST00000602355ENST00000349062STXBP2chr19

7705889

+TRIM4chr7

99490369

-
intron-3CDSENST00000602355ENST00000355947STXBP2chr19

7704693

+TRIM4chr7

99490369

-
intron-3CDSENST00000602355ENST00000355947STXBP2chr19

7705889

+TRIM4chr7

99490369

-
intron-intronENST00000602355ENST00000354241STXBP2chr19

7704693

+TRIM4chr7

99490369

-
intron-intronENST00000602355ENST00000354241STXBP2chr19

7705889

+TRIM4chr7

99490369

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000441779STXBP2chr197704693+ENST00000355947TRIM4chr799490369-2617283471866131
ENST00000441779STXBP2chr197704693+ENST00000349062TRIM4chr799490369-2617283471866131
ENST00000221283STXBP2chr197704693+ENST00000355947TRIM4chr799490369-2611277465860131
ENST00000221283STXBP2chr197704693+ENST00000349062TRIM4chr799490369-2611277465860131
ENST00000414284STXBP2chr197704693+ENST00000355947TRIM4chr799490369-2603269457852131
ENST00000414284STXBP2chr197704693+ENST00000349062TRIM4chr799490369-2603269457852131
ENST00000441779STXBP2chr197705889+ENST00000355947TRIM4chr799490369-283349937507156
ENST00000441779STXBP2chr197705889+ENST00000349062TRIM4chr799490369-283349937507156
ENST00000221283STXBP2chr197705889+ENST00000355947TRIM4chr799490369-279446031468145
ENST00000221283STXBP2chr197705889+ENST00000349062TRIM4chr799490369-279446031468145
ENST00000414284STXBP2chr197705889+ENST00000355947TRIM4chr799490369-277744323451142
ENST00000414284STXBP2chr197705889+ENST00000349062TRIM4chr799490369-277744323451142

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000441779ENST00000355947STXBP2chr197704693+TRIM4chr799490369-0.4650840.534916
ENST00000441779ENST00000349062STXBP2chr197704693+TRIM4chr799490369-0.4650840.534916
ENST00000221283ENST00000355947STXBP2chr197704693+TRIM4chr799490369-0.479912370.52008766
ENST00000221283ENST00000349062STXBP2chr197704693+TRIM4chr799490369-0.479912370.52008766
ENST00000414284ENST00000355947STXBP2chr197704693+TRIM4chr799490369-0.665801470.3341985
ENST00000414284ENST00000349062STXBP2chr197704693+TRIM4chr799490369-0.665801470.3341985
ENST00000441779ENST00000355947STXBP2chr197705889+TRIM4chr799490369-0.0043041840.9956958
ENST00000441779ENST00000349062STXBP2chr197705889+TRIM4chr799490369-0.0043041840.9956958
ENST00000221283ENST00000355947STXBP2chr197705889+TRIM4chr799490369-0.01353590.98646414
ENST00000221283ENST00000349062STXBP2chr197705889+TRIM4chr799490369-0.01353590.98646414
ENST00000414284ENST00000355947STXBP2chr197705889+TRIM4chr799490369-0.0114668670.98853314
ENST00000414284ENST00000349062STXBP2chr197705889+TRIM4chr799490369-0.0114668670.98853314

Top

Fusion Genomic Features for STXBP2-TRIM4


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for STXBP2-TRIM4


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:7704693/chr7:99490369)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTRIM4chr19:7704693chr7:99490369ENST0000035424106212_2530295.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM4chr19:7705889chr7:99490369ENST0000035424106212_2530295.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM4chr19:7704693chr7:99490369ENST0000034906246288_500280475.0DomainB30.2/SPRY
TgeneTRIM4chr19:7704693chr7:99490369ENST0000035424106288_5000295.0DomainB30.2/SPRY
TgeneTRIM4chr19:7705889chr7:99490369ENST0000034906246288_500280475.0DomainB30.2/SPRY
TgeneTRIM4chr19:7705889chr7:99490369ENST0000035424106288_5000295.0DomainB30.2/SPRY
TgeneTRIM4chr19:7704693chr7:99490369ENST000003542410612_530295.0Zinc fingerRING-type
TgeneTRIM4chr19:7704693chr7:99490369ENST000003542410682_1230295.0Zinc fingerB box-type
TgeneTRIM4chr19:7705889chr7:99490369ENST000003542410612_530295.0Zinc fingerRING-type
TgeneTRIM4chr19:7705889chr7:99490369ENST000003542410682_1230295.0Zinc fingerB box-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTRIM4chr19:7704693chr7:99490369ENST0000034906246212_253280475.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM4chr19:7704693chr7:99490369ENST0000035594757212_253306501.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM4chr19:7705889chr7:99490369ENST0000034906246212_253280475.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM4chr19:7705889chr7:99490369ENST0000035594757212_253306501.0Coiled coilOntology_term=ECO:0000255
TgeneTRIM4chr19:7704693chr7:99490369ENST0000035594757288_500306501.0DomainB30.2/SPRY
TgeneTRIM4chr19:7705889chr7:99490369ENST0000035594757288_500306501.0DomainB30.2/SPRY
TgeneTRIM4chr19:7704693chr7:99490369ENST000003490624612_53280475.0Zinc fingerRING-type
TgeneTRIM4chr19:7704693chr7:99490369ENST000003490624682_123280475.0Zinc fingerB box-type
TgeneTRIM4chr19:7704693chr7:99490369ENST000003559475712_53306501.0Zinc fingerRING-type
TgeneTRIM4chr19:7704693chr7:99490369ENST000003559475782_123306501.0Zinc fingerB box-type
TgeneTRIM4chr19:7705889chr7:99490369ENST000003490624612_53280475.0Zinc fingerRING-type
TgeneTRIM4chr19:7705889chr7:99490369ENST000003490624682_123280475.0Zinc fingerB box-type
TgeneTRIM4chr19:7705889chr7:99490369ENST000003559475712_53306501.0Zinc fingerRING-type
TgeneTRIM4chr19:7705889chr7:99490369ENST000003559475782_123306501.0Zinc fingerB box-type


Top

Fusion Gene Sequence for STXBP2-TRIM4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>87882_87882_1_STXBP2-TRIM4_STXBP2_chr19_7704693_ENST00000221283_TRIM4_chr7_99490369_ENST00000349062_length(transcript)=2611nt_BP=277nt
CCGGAAGCGGCGGCGGCGCCCCTCGGGGAAGATGGCGCCCTCGGGGCTGAAGGCGGTGGTGGGGGAAAAAATTCTGAGCGGAGTTATTCG
GAGTGTCAAGAAGGATGGGGAGTGGAAGGTGCTTATCATGGATCACCCAAGCATGCGCATCTTGTCTTCCTGCTGCAAAATGTCAGATAT
CCTGGCTGAGGGCATCACCATTGTTGAAGACATCAACAAACGGCGGGAACCCATTCCCAGTCTGGAGGCCATTTATTTGCTGAGCCCCAC
GGAGAAGTGGCTGTAAACCTAGCTGAAGACACAGCTCATCCCAAACTCGTCTTCTCCCAGGAAGGGAGATACGTGAAAAATACAGCATCA
GCCAGTTCTTGGCCAGTGTTTTCTTCAGCATGGAACTACTTTGCTGGATGGAGGAATCCTCAGAAGACTGCTTTTGTAGAGAGATTTCAG
CACTTACCCTGTGTTCTGGGAAAAAACGTTTTCACCTCAGGGAAACATTACTGGGAAGTTGAGAGTAGAGATAGTCTGGAGGTTGCTGTT
GGGGTGTGTCGGGAGGACGTCATGGGAATTACTGATCGTTCAAAAATGTCCCCAGATGTGGGCATCTGGGCGATTTATTGGAGTGCTGCT
GGCTATTGGCCCTTGATAGGCTTCCCTGGAACTCCCACCCAGCAAGAGCCAGCTCTCCACCGAGTGGGGGTTTACCTGGATCGTGGGACT
GGGAATGTCTCCTTCTACAGCGCTGTGGACGGAGTGCACCTGCACACCTTTTCTTGTTCTTCTGTCTCACGCCTCCGGCCATTTTTTTGG
TTGAGTCCATTAGCATCTTTAGTCATTCCACCAGTGACTGATAGGAAATGAGGCTTTTCTTCCCCTGACCAAAACTCCTTCCCTGTAGTC
CAGCTGAGGGACACACATCCCTGGGCCCTCTTCTGCCCTTCATGTCTCTATCCTGGATGGTCCATCTTCTGGGTCTCCCTAACGGTACCG
TTTGGTATCTGCCCTTTGTGTGCTTCACAAGAGGCAGTCCCATGGGAGGTGGGTCTGGCCAATGGAGATGGGACAGGAAATTTTCCAAGA
CGCTTTTGGGAAATCTTTTTGTAGCTTTTAAAGAGATGTGCGGGGAAGACATATGGATGTTAGCAGCCATATTGGAACTGAGAACACAGG
AATGGTGGAAAGGTAGAAGAAACAGAGTTTTTGTTGCCGTTGTGAAATTGTTGAAATTTCCTTCATGCCAAGCTTCTTGTTATATGAGAT
AATTACGCCCTTATTGTATAAGACAATTTTAGTTGTATTTGGTTACTTGCAGCCTGAAGTACCGTAACTGCACTAAAGGGACGTAGTGTG
AACATCCCGCAGTATAGGCTTAAGTCACTTTTGTGAAATTTGACAAAGGCATAGAATCTTTTTCTATCCAGTCAGGCATTGCCTATTCTT
TCCAGTAACTACTGATTCCCCCACTTTTCTGTCTTAGAAAATTGTGGGAATCCCCCCTCACTCTGCCTATGTTGCACTCTCTCTCTTCCC
AACCATAACTCTGCCCTCAGCTATTAACTGTGCTGTGTATTTATCAAGTTGGTATGTTGTATGTACAGTGTTATTCATGTCATCATGAGA
ATGTTGAACGCTTGTTAAATATCTTTTGCTAGCCTCTTCATATGCTGTTGCATATGACTCTCATCACAACTCAGTGAGATGGAAAGTCAA
ATCCTATTTGTACAAATGAGAAAACTGAACTCTTTAGAGTAACTAGCTCAGTATTGGCCAGCTGGTAAATGGCAGTGTTGGGATTAAAAT
CCAGTTCTTATCTACTCTCCCTTTATTCAGAAGCATTTATTGGATGTTGATCTTTGTTTCAGGTTTTGATTTTGTTACTTTTTTATACTG
TGTATATTTTCCTCAGTCTACCCTTCTGCTCTAGATTGTCTGGACTCAGGAGATTGTGGCAGTTACTGGATAGTTATTTTTAAGATAATG
ATTGCTTTTCTCTGTTTATATAAGTCATGTGTACTTATTGTAGAAAGTTTGTAAGATGCAAAAAGTATAAAAATTAAAGTTATGCACTAC
TAACATTTCAATATATTTTCTCCCAGATTTTCAGTAAAGACTTTCAGGCAGTGATTTAACGAGGATTTTATTTTAACTTATATTTTAGTT
TAAGGGGAACACGTGCAGGTTTGTTCTATAGATCAATTACATGTCACAGGGGTTTGGTGTACATATTATTTCATTACCCAGGTAATAAGC
ATAGTACCCAATAGATACTTTTTTGATACCCCACCCTCCTCCACCCTCTACCCTCAAGTAGTCCCTGGTGTCTGTTGTTCCCTTTTTTGT
GTCCATGGGTACTCAATGTTTAGCTCTCCCTTATACGTGAGAACATGTGATGTTTGGTTTTCTGTTCATGTGTTGGTTTGCTTAGGGTAA
TGGCCTCCAGCTCCATCCATGTTGCTGCAAAGACATGATCTCATTCTTTTTTTATGGCTGCATAGTATTCCATGGTGTATATGTACTATG
TTTTCTTTATCCAGTCTACTGTTGATGGGCATTTAGGTTGATTCCATGTCTTTGCTATTGTGAATAGTGCTGCAATGAATATATACATGC

>87882_87882_1_STXBP2-TRIM4_STXBP2_chr19_7704693_ENST00000221283_TRIM4_chr7_99490369_ENST00000349062_length(amino acids)=131AA_BP=
MGKNVFTSGKHYWEVESRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAIYWSAAGYWPLIGFPGTPTQQEPALHRVGVYLDRGTGNVSF

--------------------------------------------------------------
>87882_87882_2_STXBP2-TRIM4_STXBP2_chr19_7704693_ENST00000221283_TRIM4_chr7_99490369_ENST00000355947_length(transcript)=2611nt_BP=277nt
CCGGAAGCGGCGGCGGCGCCCCTCGGGGAAGATGGCGCCCTCGGGGCTGAAGGCGGTGGTGGGGGAAAAAATTCTGAGCGGAGTTATTCG
GAGTGTCAAGAAGGATGGGGAGTGGAAGGTGCTTATCATGGATCACCCAAGCATGCGCATCTTGTCTTCCTGCTGCAAAATGTCAGATAT
CCTGGCTGAGGGCATCACCATTGTTGAAGACATCAACAAACGGCGGGAACCCATTCCCAGTCTGGAGGCCATTTATTTGCTGAGCCCCAC
GGAGAAGTGGCTGTAAACCTAGCTGAAGACACAGCTCATCCCAAACTCGTCTTCTCCCAGGAAGGGAGATACGTGAAAAATACAGCATCA
GCCAGTTCTTGGCCAGTGTTTTCTTCAGCATGGAACTACTTTGCTGGATGGAGGAATCCTCAGAAGACTGCTTTTGTAGAGAGATTTCAG
CACTTACCCTGTGTTCTGGGAAAAAACGTTTTCACCTCAGGGAAACATTACTGGGAAGTTGAGAGTAGAGATAGTCTGGAGGTTGCTGTT
GGGGTGTGTCGGGAGGACGTCATGGGAATTACTGATCGTTCAAAAATGTCCCCAGATGTGGGCATCTGGGCGATTTATTGGAGTGCTGCT
GGCTATTGGCCCTTGATAGGCTTCCCTGGAACTCCCACCCAGCAAGAGCCAGCTCTCCACCGAGTGGGGGTTTACCTGGATCGTGGGACT
GGGAATGTCTCCTTCTACAGCGCTGTGGACGGAGTGCACCTGCACACCTTTTCTTGTTCTTCTGTCTCACGCCTCCGGCCATTTTTTTGG
TTGAGTCCATTAGCATCTTTAGTCATTCCACCAGTGACTGATAGGAAATGAGGCTTTTCTTCCCCTGACCAAAACTCCTTCCCTGTAGTC
CAGCTGAGGGACACACATCCCTGGGCCCTCTTCTGCCCTTCATGTCTCTATCCTGGATGGTCCATCTTCTGGGTCTCCCTAACGGTACCG
TTTGGTATCTGCCCTTTGTGTGCTTCACAAGAGGCAGTCCCATGGGAGGTGGGTCTGGCCAATGGAGATGGGACAGGAAATTTTCCAAGA
CGCTTTTGGGAAATCTTTTTGTAGCTTTTAAAGAGATGTGCGGGGAAGACATATGGATGTTAGCAGCCATATTGGAACTGAGAACACAGG
AATGGTGGAAAGGTAGAAGAAACAGAGTTTTTGTTGCCGTTGTGAAATTGTTGAAATTTCCTTCATGCCAAGCTTCTTGTTATATGAGAT
AATTACGCCCTTATTGTATAAGACAATTTTAGTTGTATTTGGTTACTTGCAGCCTGAAGTACCGTAACTGCACTAAAGGGACGTAGTGTG
AACATCCCGCAGTATAGGCTTAAGTCACTTTTGTGAAATTTGACAAAGGCATAGAATCTTTTTCTATCCAGTCAGGCATTGCCTATTCTT
TCCAGTAACTACTGATTCCCCCACTTTTCTGTCTTAGAAAATTGTGGGAATCCCCCCTCACTCTGCCTATGTTGCACTCTCTCTCTTCCC
AACCATAACTCTGCCCTCAGCTATTAACTGTGCTGTGTATTTATCAAGTTGGTATGTTGTATGTACAGTGTTATTCATGTCATCATGAGA
ATGTTGAACGCTTGTTAAATATCTTTTGCTAGCCTCTTCATATGCTGTTGCATATGACTCTCATCACAACTCAGTGAGATGGAAAGTCAA
ATCCTATTTGTACAAATGAGAAAACTGAACTCTTTAGAGTAACTAGCTCAGTATTGGCCAGCTGGTAAATGGCAGTGTTGGGATTAAAAT
CCAGTTCTTATCTACTCTCCCTTTATTCAGAAGCATTTATTGGATGTTGATCTTTGTTTCAGGTTTTGATTTTGTTACTTTTTTATACTG
TGTATATTTTCCTCAGTCTACCCTTCTGCTCTAGATTGTCTGGACTCAGGAGATTGTGGCAGTTACTGGATAGTTATTTTTAAGATAATG
ATTGCTTTTCTCTGTTTATATAAGTCATGTGTACTTATTGTAGAAAGTTTGTAAGATGCAAAAAGTATAAAAATTAAAGTTATGCACTAC
TAACATTTCAATATATTTTCTCCCAGATTTTCAGTAAAGACTTTCAGGCAGTGATTTAACGAGGATTTTATTTTAACTTATATTTTAGTT
TAAGGGGAACACGTGCAGGTTTGTTCTATAGATCAATTACATGTCACAGGGGTTTGGTGTACATATTATTTCATTACCCAGGTAATAAGC
ATAGTACCCAATAGATACTTTTTTGATACCCCACCCTCCTCCACCCTCTACCCTCAAGTAGTCCCTGGTGTCTGTTGTTCCCTTTTTTGT
GTCCATGGGTACTCAATGTTTAGCTCTCCCTTATACGTGAGAACATGTGATGTTTGGTTTTCTGTTCATGTGTTGGTTTGCTTAGGGTAA
TGGCCTCCAGCTCCATCCATGTTGCTGCAAAGACATGATCTCATTCTTTTTTTATGGCTGCATAGTATTCCATGGTGTATATGTACTATG
TTTTCTTTATCCAGTCTACTGTTGATGGGCATTTAGGTTGATTCCATGTCTTTGCTATTGTGAATAGTGCTGCAATGAATATATACATGC

>87882_87882_2_STXBP2-TRIM4_STXBP2_chr19_7704693_ENST00000221283_TRIM4_chr7_99490369_ENST00000355947_length(amino acids)=131AA_BP=
MGKNVFTSGKHYWEVESRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAIYWSAAGYWPLIGFPGTPTQQEPALHRVGVYLDRGTGNVSF

--------------------------------------------------------------
>87882_87882_3_STXBP2-TRIM4_STXBP2_chr19_7704693_ENST00000414284_TRIM4_chr7_99490369_ENST00000349062_length(transcript)=2603nt_BP=269nt
GGCGGCGGCGCCCCTCGGGGAAGATGGCGCCCTCGGGGCTGAAGGCGGTGGTGGGGGAAAAAATTCTGAGCGGAGTTATTCGGAGTGTCA
AGAAGGATGGGGAGTGGAAGGTGCTTATCATGGATCACCCAAGCATGCGCATCTTGTCTTCCTGCTGCAAAATGTCAGATATCCTGGCTG
AGGGCATCACCATTGTTGAAGACATCAACAAACGGCGGGAACCCATTCCCAGTCTGGAGGCCATTTATTTGCTGAGCCCCACGGAGAAGT
GGCTGTAAACCTAGCTGAAGACACAGCTCATCCCAAACTCGTCTTCTCCCAGGAAGGGAGATACGTGAAAAATACAGCATCAGCCAGTTC
TTGGCCAGTGTTTTCTTCAGCATGGAACTACTTTGCTGGATGGAGGAATCCTCAGAAGACTGCTTTTGTAGAGAGATTTCAGCACTTACC
CTGTGTTCTGGGAAAAAACGTTTTCACCTCAGGGAAACATTACTGGGAAGTTGAGAGTAGAGATAGTCTGGAGGTTGCTGTTGGGGTGTG
TCGGGAGGACGTCATGGGAATTACTGATCGTTCAAAAATGTCCCCAGATGTGGGCATCTGGGCGATTTATTGGAGTGCTGCTGGCTATTG
GCCCTTGATAGGCTTCCCTGGAACTCCCACCCAGCAAGAGCCAGCTCTCCACCGAGTGGGGGTTTACCTGGATCGTGGGACTGGGAATGT
CTCCTTCTACAGCGCTGTGGACGGAGTGCACCTGCACACCTTTTCTTGTTCTTCTGTCTCACGCCTCCGGCCATTTTTTTGGTTGAGTCC
ATTAGCATCTTTAGTCATTCCACCAGTGACTGATAGGAAATGAGGCTTTTCTTCCCCTGACCAAAACTCCTTCCCTGTAGTCCAGCTGAG
GGACACACATCCCTGGGCCCTCTTCTGCCCTTCATGTCTCTATCCTGGATGGTCCATCTTCTGGGTCTCCCTAACGGTACCGTTTGGTAT
CTGCCCTTTGTGTGCTTCACAAGAGGCAGTCCCATGGGAGGTGGGTCTGGCCAATGGAGATGGGACAGGAAATTTTCCAAGACGCTTTTG
GGAAATCTTTTTGTAGCTTTTAAAGAGATGTGCGGGGAAGACATATGGATGTTAGCAGCCATATTGGAACTGAGAACACAGGAATGGTGG
AAAGGTAGAAGAAACAGAGTTTTTGTTGCCGTTGTGAAATTGTTGAAATTTCCTTCATGCCAAGCTTCTTGTTATATGAGATAATTACGC
CCTTATTGTATAAGACAATTTTAGTTGTATTTGGTTACTTGCAGCCTGAAGTACCGTAACTGCACTAAAGGGACGTAGTGTGAACATCCC
GCAGTATAGGCTTAAGTCACTTTTGTGAAATTTGACAAAGGCATAGAATCTTTTTCTATCCAGTCAGGCATTGCCTATTCTTTCCAGTAA
CTACTGATTCCCCCACTTTTCTGTCTTAGAAAATTGTGGGAATCCCCCCTCACTCTGCCTATGTTGCACTCTCTCTCTTCCCAACCATAA
CTCTGCCCTCAGCTATTAACTGTGCTGTGTATTTATCAAGTTGGTATGTTGTATGTACAGTGTTATTCATGTCATCATGAGAATGTTGAA
CGCTTGTTAAATATCTTTTGCTAGCCTCTTCATATGCTGTTGCATATGACTCTCATCACAACTCAGTGAGATGGAAAGTCAAATCCTATT
TGTACAAATGAGAAAACTGAACTCTTTAGAGTAACTAGCTCAGTATTGGCCAGCTGGTAAATGGCAGTGTTGGGATTAAAATCCAGTTCT
TATCTACTCTCCCTTTATTCAGAAGCATTTATTGGATGTTGATCTTTGTTTCAGGTTTTGATTTTGTTACTTTTTTATACTGTGTATATT
TTCCTCAGTCTACCCTTCTGCTCTAGATTGTCTGGACTCAGGAGATTGTGGCAGTTACTGGATAGTTATTTTTAAGATAATGATTGCTTT
TCTCTGTTTATATAAGTCATGTGTACTTATTGTAGAAAGTTTGTAAGATGCAAAAAGTATAAAAATTAAAGTTATGCACTACTAACATTT
CAATATATTTTCTCCCAGATTTTCAGTAAAGACTTTCAGGCAGTGATTTAACGAGGATTTTATTTTAACTTATATTTTAGTTTAAGGGGA
ACACGTGCAGGTTTGTTCTATAGATCAATTACATGTCACAGGGGTTTGGTGTACATATTATTTCATTACCCAGGTAATAAGCATAGTACC
CAATAGATACTTTTTTGATACCCCACCCTCCTCCACCCTCTACCCTCAAGTAGTCCCTGGTGTCTGTTGTTCCCTTTTTTGTGTCCATGG
GTACTCAATGTTTAGCTCTCCCTTATACGTGAGAACATGTGATGTTTGGTTTTCTGTTCATGTGTTGGTTTGCTTAGGGTAATGGCCTCC
AGCTCCATCCATGTTGCTGCAAAGACATGATCTCATTCTTTTTTTATGGCTGCATAGTATTCCATGGTGTATATGTACTATGTTTTCTTT

>87882_87882_3_STXBP2-TRIM4_STXBP2_chr19_7704693_ENST00000414284_TRIM4_chr7_99490369_ENST00000349062_length(amino acids)=131AA_BP=
MGKNVFTSGKHYWEVESRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAIYWSAAGYWPLIGFPGTPTQQEPALHRVGVYLDRGTGNVSF

--------------------------------------------------------------
>87882_87882_4_STXBP2-TRIM4_STXBP2_chr19_7704693_ENST00000414284_TRIM4_chr7_99490369_ENST00000355947_length(transcript)=2603nt_BP=269nt
GGCGGCGGCGCCCCTCGGGGAAGATGGCGCCCTCGGGGCTGAAGGCGGTGGTGGGGGAAAAAATTCTGAGCGGAGTTATTCGGAGTGTCA
AGAAGGATGGGGAGTGGAAGGTGCTTATCATGGATCACCCAAGCATGCGCATCTTGTCTTCCTGCTGCAAAATGTCAGATATCCTGGCTG
AGGGCATCACCATTGTTGAAGACATCAACAAACGGCGGGAACCCATTCCCAGTCTGGAGGCCATTTATTTGCTGAGCCCCACGGAGAAGT
GGCTGTAAACCTAGCTGAAGACACAGCTCATCCCAAACTCGTCTTCTCCCAGGAAGGGAGATACGTGAAAAATACAGCATCAGCCAGTTC
TTGGCCAGTGTTTTCTTCAGCATGGAACTACTTTGCTGGATGGAGGAATCCTCAGAAGACTGCTTTTGTAGAGAGATTTCAGCACTTACC
CTGTGTTCTGGGAAAAAACGTTTTCACCTCAGGGAAACATTACTGGGAAGTTGAGAGTAGAGATAGTCTGGAGGTTGCTGTTGGGGTGTG
TCGGGAGGACGTCATGGGAATTACTGATCGTTCAAAAATGTCCCCAGATGTGGGCATCTGGGCGATTTATTGGAGTGCTGCTGGCTATTG
GCCCTTGATAGGCTTCCCTGGAACTCCCACCCAGCAAGAGCCAGCTCTCCACCGAGTGGGGGTTTACCTGGATCGTGGGACTGGGAATGT
CTCCTTCTACAGCGCTGTGGACGGAGTGCACCTGCACACCTTTTCTTGTTCTTCTGTCTCACGCCTCCGGCCATTTTTTTGGTTGAGTCC
ATTAGCATCTTTAGTCATTCCACCAGTGACTGATAGGAAATGAGGCTTTTCTTCCCCTGACCAAAACTCCTTCCCTGTAGTCCAGCTGAG
GGACACACATCCCTGGGCCCTCTTCTGCCCTTCATGTCTCTATCCTGGATGGTCCATCTTCTGGGTCTCCCTAACGGTACCGTTTGGTAT
CTGCCCTTTGTGTGCTTCACAAGAGGCAGTCCCATGGGAGGTGGGTCTGGCCAATGGAGATGGGACAGGAAATTTTCCAAGACGCTTTTG
GGAAATCTTTTTGTAGCTTTTAAAGAGATGTGCGGGGAAGACATATGGATGTTAGCAGCCATATTGGAACTGAGAACACAGGAATGGTGG
AAAGGTAGAAGAAACAGAGTTTTTGTTGCCGTTGTGAAATTGTTGAAATTTCCTTCATGCCAAGCTTCTTGTTATATGAGATAATTACGC
CCTTATTGTATAAGACAATTTTAGTTGTATTTGGTTACTTGCAGCCTGAAGTACCGTAACTGCACTAAAGGGACGTAGTGTGAACATCCC
GCAGTATAGGCTTAAGTCACTTTTGTGAAATTTGACAAAGGCATAGAATCTTTTTCTATCCAGTCAGGCATTGCCTATTCTTTCCAGTAA
CTACTGATTCCCCCACTTTTCTGTCTTAGAAAATTGTGGGAATCCCCCCTCACTCTGCCTATGTTGCACTCTCTCTCTTCCCAACCATAA
CTCTGCCCTCAGCTATTAACTGTGCTGTGTATTTATCAAGTTGGTATGTTGTATGTACAGTGTTATTCATGTCATCATGAGAATGTTGAA
CGCTTGTTAAATATCTTTTGCTAGCCTCTTCATATGCTGTTGCATATGACTCTCATCACAACTCAGTGAGATGGAAAGTCAAATCCTATT
TGTACAAATGAGAAAACTGAACTCTTTAGAGTAACTAGCTCAGTATTGGCCAGCTGGTAAATGGCAGTGTTGGGATTAAAATCCAGTTCT
TATCTACTCTCCCTTTATTCAGAAGCATTTATTGGATGTTGATCTTTGTTTCAGGTTTTGATTTTGTTACTTTTTTATACTGTGTATATT
TTCCTCAGTCTACCCTTCTGCTCTAGATTGTCTGGACTCAGGAGATTGTGGCAGTTACTGGATAGTTATTTTTAAGATAATGATTGCTTT
TCTCTGTTTATATAAGTCATGTGTACTTATTGTAGAAAGTTTGTAAGATGCAAAAAGTATAAAAATTAAAGTTATGCACTACTAACATTT
CAATATATTTTCTCCCAGATTTTCAGTAAAGACTTTCAGGCAGTGATTTAACGAGGATTTTATTTTAACTTATATTTTAGTTTAAGGGGA
ACACGTGCAGGTTTGTTCTATAGATCAATTACATGTCACAGGGGTTTGGTGTACATATTATTTCATTACCCAGGTAATAAGCATAGTACC
CAATAGATACTTTTTTGATACCCCACCCTCCTCCACCCTCTACCCTCAAGTAGTCCCTGGTGTCTGTTGTTCCCTTTTTTGTGTCCATGG
GTACTCAATGTTTAGCTCTCCCTTATACGTGAGAACATGTGATGTTTGGTTTTCTGTTCATGTGTTGGTTTGCTTAGGGTAATGGCCTCC
AGCTCCATCCATGTTGCTGCAAAGACATGATCTCATTCTTTTTTTATGGCTGCATAGTATTCCATGGTGTATATGTACTATGTTTTCTTT

>87882_87882_4_STXBP2-TRIM4_STXBP2_chr19_7704693_ENST00000414284_TRIM4_chr7_99490369_ENST00000355947_length(amino acids)=131AA_BP=
MGKNVFTSGKHYWEVESRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAIYWSAAGYWPLIGFPGTPTQQEPALHRVGVYLDRGTGNVSF

--------------------------------------------------------------
>87882_87882_5_STXBP2-TRIM4_STXBP2_chr19_7704693_ENST00000441779_TRIM4_chr7_99490369_ENST00000349062_length(transcript)=2617nt_BP=283nt
ACACACCCGGAAGCGGCGGCGGCGCCCCTCGGGGAAGATGGCGCCCTCGGGGCTGAAGGCGGTGGTGGGGGAAAAAATTCTGAGCGGAGT
TATTCGGAGTGTCAAGAAGGATGGGGAGTGGAAGGTGCTTATCATGGATCACCCAAGCATGCGCATCTTGTCTTCCTGCTGCAAAATGTC
AGATATCCTGGCTGAGGGCATCACCATTGTTGAAGACATCAACAAACGGCGGGAACCCATTCCCAGTCTGGAGGCCATTTATTTGCTGAG
CCCCACGGAGAAGTGGCTGTAAACCTAGCTGAAGACACAGCTCATCCCAAACTCGTCTTCTCCCAGGAAGGGAGATACGTGAAAAATACA
GCATCAGCCAGTTCTTGGCCAGTGTTTTCTTCAGCATGGAACTACTTTGCTGGATGGAGGAATCCTCAGAAGACTGCTTTTGTAGAGAGA
TTTCAGCACTTACCCTGTGTTCTGGGAAAAAACGTTTTCACCTCAGGGAAACATTACTGGGAAGTTGAGAGTAGAGATAGTCTGGAGGTT
GCTGTTGGGGTGTGTCGGGAGGACGTCATGGGAATTACTGATCGTTCAAAAATGTCCCCAGATGTGGGCATCTGGGCGATTTATTGGAGT
GCTGCTGGCTATTGGCCCTTGATAGGCTTCCCTGGAACTCCCACCCAGCAAGAGCCAGCTCTCCACCGAGTGGGGGTTTACCTGGATCGT
GGGACTGGGAATGTCTCCTTCTACAGCGCTGTGGACGGAGTGCACCTGCACACCTTTTCTTGTTCTTCTGTCTCACGCCTCCGGCCATTT
TTTTGGTTGAGTCCATTAGCATCTTTAGTCATTCCACCAGTGACTGATAGGAAATGAGGCTTTTCTTCCCCTGACCAAAACTCCTTCCCT
GTAGTCCAGCTGAGGGACACACATCCCTGGGCCCTCTTCTGCCCTTCATGTCTCTATCCTGGATGGTCCATCTTCTGGGTCTCCCTAACG
GTACCGTTTGGTATCTGCCCTTTGTGTGCTTCACAAGAGGCAGTCCCATGGGAGGTGGGTCTGGCCAATGGAGATGGGACAGGAAATTTT
CCAAGACGCTTTTGGGAAATCTTTTTGTAGCTTTTAAAGAGATGTGCGGGGAAGACATATGGATGTTAGCAGCCATATTGGAACTGAGAA
CACAGGAATGGTGGAAAGGTAGAAGAAACAGAGTTTTTGTTGCCGTTGTGAAATTGTTGAAATTTCCTTCATGCCAAGCTTCTTGTTATA
TGAGATAATTACGCCCTTATTGTATAAGACAATTTTAGTTGTATTTGGTTACTTGCAGCCTGAAGTACCGTAACTGCACTAAAGGGACGT
AGTGTGAACATCCCGCAGTATAGGCTTAAGTCACTTTTGTGAAATTTGACAAAGGCATAGAATCTTTTTCTATCCAGTCAGGCATTGCCT
ATTCTTTCCAGTAACTACTGATTCCCCCACTTTTCTGTCTTAGAAAATTGTGGGAATCCCCCCTCACTCTGCCTATGTTGCACTCTCTCT
CTTCCCAACCATAACTCTGCCCTCAGCTATTAACTGTGCTGTGTATTTATCAAGTTGGTATGTTGTATGTACAGTGTTATTCATGTCATC
ATGAGAATGTTGAACGCTTGTTAAATATCTTTTGCTAGCCTCTTCATATGCTGTTGCATATGACTCTCATCACAACTCAGTGAGATGGAA
AGTCAAATCCTATTTGTACAAATGAGAAAACTGAACTCTTTAGAGTAACTAGCTCAGTATTGGCCAGCTGGTAAATGGCAGTGTTGGGAT
TAAAATCCAGTTCTTATCTACTCTCCCTTTATTCAGAAGCATTTATTGGATGTTGATCTTTGTTTCAGGTTTTGATTTTGTTACTTTTTT
ATACTGTGTATATTTTCCTCAGTCTACCCTTCTGCTCTAGATTGTCTGGACTCAGGAGATTGTGGCAGTTACTGGATAGTTATTTTTAAG
ATAATGATTGCTTTTCTCTGTTTATATAAGTCATGTGTACTTATTGTAGAAAGTTTGTAAGATGCAAAAAGTATAAAAATTAAAGTTATG
CACTACTAACATTTCAATATATTTTCTCCCAGATTTTCAGTAAAGACTTTCAGGCAGTGATTTAACGAGGATTTTATTTTAACTTATATT
TTAGTTTAAGGGGAACACGTGCAGGTTTGTTCTATAGATCAATTACATGTCACAGGGGTTTGGTGTACATATTATTTCATTACCCAGGTA
ATAAGCATAGTACCCAATAGATACTTTTTTGATACCCCACCCTCCTCCACCCTCTACCCTCAAGTAGTCCCTGGTGTCTGTTGTTCCCTT
TTTTGTGTCCATGGGTACTCAATGTTTAGCTCTCCCTTATACGTGAGAACATGTGATGTTTGGTTTTCTGTTCATGTGTTGGTTTGCTTA
GGGTAATGGCCTCCAGCTCCATCCATGTTGCTGCAAAGACATGATCTCATTCTTTTTTTATGGCTGCATAGTATTCCATGGTGTATATGT
ACTATGTTTTCTTTATCCAGTCTACTGTTGATGGGCATTTAGGTTGATTCCATGTCTTTGCTATTGTGAATAGTGCTGCAATGAATATAT

>87882_87882_5_STXBP2-TRIM4_STXBP2_chr19_7704693_ENST00000441779_TRIM4_chr7_99490369_ENST00000349062_length(amino acids)=131AA_BP=
MGKNVFTSGKHYWEVESRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAIYWSAAGYWPLIGFPGTPTQQEPALHRVGVYLDRGTGNVSF

--------------------------------------------------------------
>87882_87882_6_STXBP2-TRIM4_STXBP2_chr19_7704693_ENST00000441779_TRIM4_chr7_99490369_ENST00000355947_length(transcript)=2617nt_BP=283nt
ACACACCCGGAAGCGGCGGCGGCGCCCCTCGGGGAAGATGGCGCCCTCGGGGCTGAAGGCGGTGGTGGGGGAAAAAATTCTGAGCGGAGT
TATTCGGAGTGTCAAGAAGGATGGGGAGTGGAAGGTGCTTATCATGGATCACCCAAGCATGCGCATCTTGTCTTCCTGCTGCAAAATGTC
AGATATCCTGGCTGAGGGCATCACCATTGTTGAAGACATCAACAAACGGCGGGAACCCATTCCCAGTCTGGAGGCCATTTATTTGCTGAG
CCCCACGGAGAAGTGGCTGTAAACCTAGCTGAAGACACAGCTCATCCCAAACTCGTCTTCTCCCAGGAAGGGAGATACGTGAAAAATACA
GCATCAGCCAGTTCTTGGCCAGTGTTTTCTTCAGCATGGAACTACTTTGCTGGATGGAGGAATCCTCAGAAGACTGCTTTTGTAGAGAGA
TTTCAGCACTTACCCTGTGTTCTGGGAAAAAACGTTTTCACCTCAGGGAAACATTACTGGGAAGTTGAGAGTAGAGATAGTCTGGAGGTT
GCTGTTGGGGTGTGTCGGGAGGACGTCATGGGAATTACTGATCGTTCAAAAATGTCCCCAGATGTGGGCATCTGGGCGATTTATTGGAGT
GCTGCTGGCTATTGGCCCTTGATAGGCTTCCCTGGAACTCCCACCCAGCAAGAGCCAGCTCTCCACCGAGTGGGGGTTTACCTGGATCGT
GGGACTGGGAATGTCTCCTTCTACAGCGCTGTGGACGGAGTGCACCTGCACACCTTTTCTTGTTCTTCTGTCTCACGCCTCCGGCCATTT
TTTTGGTTGAGTCCATTAGCATCTTTAGTCATTCCACCAGTGACTGATAGGAAATGAGGCTTTTCTTCCCCTGACCAAAACTCCTTCCCT
GTAGTCCAGCTGAGGGACACACATCCCTGGGCCCTCTTCTGCCCTTCATGTCTCTATCCTGGATGGTCCATCTTCTGGGTCTCCCTAACG
GTACCGTTTGGTATCTGCCCTTTGTGTGCTTCACAAGAGGCAGTCCCATGGGAGGTGGGTCTGGCCAATGGAGATGGGACAGGAAATTTT
CCAAGACGCTTTTGGGAAATCTTTTTGTAGCTTTTAAAGAGATGTGCGGGGAAGACATATGGATGTTAGCAGCCATATTGGAACTGAGAA
CACAGGAATGGTGGAAAGGTAGAAGAAACAGAGTTTTTGTTGCCGTTGTGAAATTGTTGAAATTTCCTTCATGCCAAGCTTCTTGTTATA
TGAGATAATTACGCCCTTATTGTATAAGACAATTTTAGTTGTATTTGGTTACTTGCAGCCTGAAGTACCGTAACTGCACTAAAGGGACGT
AGTGTGAACATCCCGCAGTATAGGCTTAAGTCACTTTTGTGAAATTTGACAAAGGCATAGAATCTTTTTCTATCCAGTCAGGCATTGCCT
ATTCTTTCCAGTAACTACTGATTCCCCCACTTTTCTGTCTTAGAAAATTGTGGGAATCCCCCCTCACTCTGCCTATGTTGCACTCTCTCT
CTTCCCAACCATAACTCTGCCCTCAGCTATTAACTGTGCTGTGTATTTATCAAGTTGGTATGTTGTATGTACAGTGTTATTCATGTCATC
ATGAGAATGTTGAACGCTTGTTAAATATCTTTTGCTAGCCTCTTCATATGCTGTTGCATATGACTCTCATCACAACTCAGTGAGATGGAA
AGTCAAATCCTATTTGTACAAATGAGAAAACTGAACTCTTTAGAGTAACTAGCTCAGTATTGGCCAGCTGGTAAATGGCAGTGTTGGGAT
TAAAATCCAGTTCTTATCTACTCTCCCTTTATTCAGAAGCATTTATTGGATGTTGATCTTTGTTTCAGGTTTTGATTTTGTTACTTTTTT
ATACTGTGTATATTTTCCTCAGTCTACCCTTCTGCTCTAGATTGTCTGGACTCAGGAGATTGTGGCAGTTACTGGATAGTTATTTTTAAG
ATAATGATTGCTTTTCTCTGTTTATATAAGTCATGTGTACTTATTGTAGAAAGTTTGTAAGATGCAAAAAGTATAAAAATTAAAGTTATG
CACTACTAACATTTCAATATATTTTCTCCCAGATTTTCAGTAAAGACTTTCAGGCAGTGATTTAACGAGGATTTTATTTTAACTTATATT
TTAGTTTAAGGGGAACACGTGCAGGTTTGTTCTATAGATCAATTACATGTCACAGGGGTTTGGTGTACATATTATTTCATTACCCAGGTA
ATAAGCATAGTACCCAATAGATACTTTTTTGATACCCCACCCTCCTCCACCCTCTACCCTCAAGTAGTCCCTGGTGTCTGTTGTTCCCTT
TTTTGTGTCCATGGGTACTCAATGTTTAGCTCTCCCTTATACGTGAGAACATGTGATGTTTGGTTTTCTGTTCATGTGTTGGTTTGCTTA
GGGTAATGGCCTCCAGCTCCATCCATGTTGCTGCAAAGACATGATCTCATTCTTTTTTTATGGCTGCATAGTATTCCATGGTGTATATGT
ACTATGTTTTCTTTATCCAGTCTACTGTTGATGGGCATTTAGGTTGATTCCATGTCTTTGCTATTGTGAATAGTGCTGCAATGAATATAT

>87882_87882_6_STXBP2-TRIM4_STXBP2_chr19_7704693_ENST00000441779_TRIM4_chr7_99490369_ENST00000355947_length(amino acids)=131AA_BP=
MGKNVFTSGKHYWEVESRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAIYWSAAGYWPLIGFPGTPTQQEPALHRVGVYLDRGTGNVSF

--------------------------------------------------------------
>87882_87882_7_STXBP2-TRIM4_STXBP2_chr19_7705889_ENST00000221283_TRIM4_chr7_99490369_ENST00000349062_length(transcript)=2794nt_BP=460nt
CCGGAAGCGGCGGCGGCGCCCCTCGGGGAAGATGGCGCCCTCGGGGCTGAAGGCGGTGGTGGGGGAAAAAATTCTGAGCGGAGTTATTCG
GAGTGTCAAGAAGGATGGGGAGTGGAAGGTGCTTATCATGGATCACCCAAGCATGCGCATCTTGTCTTCCTGCTGCAAAATGTCAGATAT
CCTGGCTGAGGGCATCACCATTGTTGAAGACATCAACAAACGGCGGGAACCCATTCCCAGTCTGGAGGCCATTTATTTGCTGAGCCCCAC
GGAGAAGTCGGTTCAGGCCCTGATCAAAGACTTCCAGGGGACCCCGACTTTCACCTACAAAGCGGCCCATATCTTCTTCACCGACACCTG
CCCCGAGCCCCTGTTCAGTGAGCTAGGCCGCTCTCGTCTGGCAAAGGTGGTGAAGACGTTGAAGGAGATTCACCTTGCCTTCCTCCCCTA
CGAGGCCCAGTGGCTGTAAACCTAGCTGAAGACACAGCTCATCCCAAACTCGTCTTCTCCCAGGAAGGGAGATACGTGAAAAATACAGCA
TCAGCCAGTTCTTGGCCAGTGTTTTCTTCAGCATGGAACTACTTTGCTGGATGGAGGAATCCTCAGAAGACTGCTTTTGTAGAGAGATTT
CAGCACTTACCCTGTGTTCTGGGAAAAAACGTTTTCACCTCAGGGAAACATTACTGGGAAGTTGAGAGTAGAGATAGTCTGGAGGTTGCT
GTTGGGGTGTGTCGGGAGGACGTCATGGGAATTACTGATCGTTCAAAAATGTCCCCAGATGTGGGCATCTGGGCGATTTATTGGAGTGCT
GCTGGCTATTGGCCCTTGATAGGCTTCCCTGGAACTCCCACCCAGCAAGAGCCAGCTCTCCACCGAGTGGGGGTTTACCTGGATCGTGGG
ACTGGGAATGTCTCCTTCTACAGCGCTGTGGACGGAGTGCACCTGCACACCTTTTCTTGTTCTTCTGTCTCACGCCTCCGGCCATTTTTT
TGGTTGAGTCCATTAGCATCTTTAGTCATTCCACCAGTGACTGATAGGAAATGAGGCTTTTCTTCCCCTGACCAAAACTCCTTCCCTGTA
GTCCAGCTGAGGGACACACATCCCTGGGCCCTCTTCTGCCCTTCATGTCTCTATCCTGGATGGTCCATCTTCTGGGTCTCCCTAACGGTA
CCGTTTGGTATCTGCCCTTTGTGTGCTTCACAAGAGGCAGTCCCATGGGAGGTGGGTCTGGCCAATGGAGATGGGACAGGAAATTTTCCA
AGACGCTTTTGGGAAATCTTTTTGTAGCTTTTAAAGAGATGTGCGGGGAAGACATATGGATGTTAGCAGCCATATTGGAACTGAGAACAC
AGGAATGGTGGAAAGGTAGAAGAAACAGAGTTTTTGTTGCCGTTGTGAAATTGTTGAAATTTCCTTCATGCCAAGCTTCTTGTTATATGA
GATAATTACGCCCTTATTGTATAAGACAATTTTAGTTGTATTTGGTTACTTGCAGCCTGAAGTACCGTAACTGCACTAAAGGGACGTAGT
GTGAACATCCCGCAGTATAGGCTTAAGTCACTTTTGTGAAATTTGACAAAGGCATAGAATCTTTTTCTATCCAGTCAGGCATTGCCTATT
CTTTCCAGTAACTACTGATTCCCCCACTTTTCTGTCTTAGAAAATTGTGGGAATCCCCCCTCACTCTGCCTATGTTGCACTCTCTCTCTT
CCCAACCATAACTCTGCCCTCAGCTATTAACTGTGCTGTGTATTTATCAAGTTGGTATGTTGTATGTACAGTGTTATTCATGTCATCATG
AGAATGTTGAACGCTTGTTAAATATCTTTTGCTAGCCTCTTCATATGCTGTTGCATATGACTCTCATCACAACTCAGTGAGATGGAAAGT
CAAATCCTATTTGTACAAATGAGAAAACTGAACTCTTTAGAGTAACTAGCTCAGTATTGGCCAGCTGGTAAATGGCAGTGTTGGGATTAA
AATCCAGTTCTTATCTACTCTCCCTTTATTCAGAAGCATTTATTGGATGTTGATCTTTGTTTCAGGTTTTGATTTTGTTACTTTTTTATA
CTGTGTATATTTTCCTCAGTCTACCCTTCTGCTCTAGATTGTCTGGACTCAGGAGATTGTGGCAGTTACTGGATAGTTATTTTTAAGATA
ATGATTGCTTTTCTCTGTTTATATAAGTCATGTGTACTTATTGTAGAAAGTTTGTAAGATGCAAAAAGTATAAAAATTAAAGTTATGCAC
TACTAACATTTCAATATATTTTCTCCCAGATTTTCAGTAAAGACTTTCAGGCAGTGATTTAACGAGGATTTTATTTTAACTTATATTTTA
GTTTAAGGGGAACACGTGCAGGTTTGTTCTATAGATCAATTACATGTCACAGGGGTTTGGTGTACATATTATTTCATTACCCAGGTAATA
AGCATAGTACCCAATAGATACTTTTTTGATACCCCACCCTCCTCCACCCTCTACCCTCAAGTAGTCCCTGGTGTCTGTTGTTCCCTTTTT
TGTGTCCATGGGTACTCAATGTTTAGCTCTCCCTTATACGTGAGAACATGTGATGTTTGGTTTTCTGTTCATGTGTTGGTTTGCTTAGGG
TAATGGCCTCCAGCTCCATCCATGTTGCTGCAAAGACATGATCTCATTCTTTTTTTATGGCTGCATAGTATTCCATGGTGTATATGTACT
ATGTTTTCTTTATCCAGTCTACTGTTGATGGGCATTTAGGTTGATTCCATGTCTTTGCTATTGTGAATAGTGCTGCAATGAATATATACA

>87882_87882_7_STXBP2-TRIM4_STXBP2_chr19_7705889_ENST00000221283_TRIM4_chr7_99490369_ENST00000349062_length(amino acids)=145AA_BP=
MAPSGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVEDINKRREPIPSLEAIYLLSPTEKSVQALIKD

--------------------------------------------------------------
>87882_87882_8_STXBP2-TRIM4_STXBP2_chr19_7705889_ENST00000221283_TRIM4_chr7_99490369_ENST00000355947_length(transcript)=2794nt_BP=460nt
CCGGAAGCGGCGGCGGCGCCCCTCGGGGAAGATGGCGCCCTCGGGGCTGAAGGCGGTGGTGGGGGAAAAAATTCTGAGCGGAGTTATTCG
GAGTGTCAAGAAGGATGGGGAGTGGAAGGTGCTTATCATGGATCACCCAAGCATGCGCATCTTGTCTTCCTGCTGCAAAATGTCAGATAT
CCTGGCTGAGGGCATCACCATTGTTGAAGACATCAACAAACGGCGGGAACCCATTCCCAGTCTGGAGGCCATTTATTTGCTGAGCCCCAC
GGAGAAGTCGGTTCAGGCCCTGATCAAAGACTTCCAGGGGACCCCGACTTTCACCTACAAAGCGGCCCATATCTTCTTCACCGACACCTG
CCCCGAGCCCCTGTTCAGTGAGCTAGGCCGCTCTCGTCTGGCAAAGGTGGTGAAGACGTTGAAGGAGATTCACCTTGCCTTCCTCCCCTA
CGAGGCCCAGTGGCTGTAAACCTAGCTGAAGACACAGCTCATCCCAAACTCGTCTTCTCCCAGGAAGGGAGATACGTGAAAAATACAGCA
TCAGCCAGTTCTTGGCCAGTGTTTTCTTCAGCATGGAACTACTTTGCTGGATGGAGGAATCCTCAGAAGACTGCTTTTGTAGAGAGATTT
CAGCACTTACCCTGTGTTCTGGGAAAAAACGTTTTCACCTCAGGGAAACATTACTGGGAAGTTGAGAGTAGAGATAGTCTGGAGGTTGCT
GTTGGGGTGTGTCGGGAGGACGTCATGGGAATTACTGATCGTTCAAAAATGTCCCCAGATGTGGGCATCTGGGCGATTTATTGGAGTGCT
GCTGGCTATTGGCCCTTGATAGGCTTCCCTGGAACTCCCACCCAGCAAGAGCCAGCTCTCCACCGAGTGGGGGTTTACCTGGATCGTGGG
ACTGGGAATGTCTCCTTCTACAGCGCTGTGGACGGAGTGCACCTGCACACCTTTTCTTGTTCTTCTGTCTCACGCCTCCGGCCATTTTTT
TGGTTGAGTCCATTAGCATCTTTAGTCATTCCACCAGTGACTGATAGGAAATGAGGCTTTTCTTCCCCTGACCAAAACTCCTTCCCTGTA
GTCCAGCTGAGGGACACACATCCCTGGGCCCTCTTCTGCCCTTCATGTCTCTATCCTGGATGGTCCATCTTCTGGGTCTCCCTAACGGTA
CCGTTTGGTATCTGCCCTTTGTGTGCTTCACAAGAGGCAGTCCCATGGGAGGTGGGTCTGGCCAATGGAGATGGGACAGGAAATTTTCCA
AGACGCTTTTGGGAAATCTTTTTGTAGCTTTTAAAGAGATGTGCGGGGAAGACATATGGATGTTAGCAGCCATATTGGAACTGAGAACAC
AGGAATGGTGGAAAGGTAGAAGAAACAGAGTTTTTGTTGCCGTTGTGAAATTGTTGAAATTTCCTTCATGCCAAGCTTCTTGTTATATGA
GATAATTACGCCCTTATTGTATAAGACAATTTTAGTTGTATTTGGTTACTTGCAGCCTGAAGTACCGTAACTGCACTAAAGGGACGTAGT
GTGAACATCCCGCAGTATAGGCTTAAGTCACTTTTGTGAAATTTGACAAAGGCATAGAATCTTTTTCTATCCAGTCAGGCATTGCCTATT
CTTTCCAGTAACTACTGATTCCCCCACTTTTCTGTCTTAGAAAATTGTGGGAATCCCCCCTCACTCTGCCTATGTTGCACTCTCTCTCTT
CCCAACCATAACTCTGCCCTCAGCTATTAACTGTGCTGTGTATTTATCAAGTTGGTATGTTGTATGTACAGTGTTATTCATGTCATCATG
AGAATGTTGAACGCTTGTTAAATATCTTTTGCTAGCCTCTTCATATGCTGTTGCATATGACTCTCATCACAACTCAGTGAGATGGAAAGT
CAAATCCTATTTGTACAAATGAGAAAACTGAACTCTTTAGAGTAACTAGCTCAGTATTGGCCAGCTGGTAAATGGCAGTGTTGGGATTAA
AATCCAGTTCTTATCTACTCTCCCTTTATTCAGAAGCATTTATTGGATGTTGATCTTTGTTTCAGGTTTTGATTTTGTTACTTTTTTATA
CTGTGTATATTTTCCTCAGTCTACCCTTCTGCTCTAGATTGTCTGGACTCAGGAGATTGTGGCAGTTACTGGATAGTTATTTTTAAGATA
ATGATTGCTTTTCTCTGTTTATATAAGTCATGTGTACTTATTGTAGAAAGTTTGTAAGATGCAAAAAGTATAAAAATTAAAGTTATGCAC
TACTAACATTTCAATATATTTTCTCCCAGATTTTCAGTAAAGACTTTCAGGCAGTGATTTAACGAGGATTTTATTTTAACTTATATTTTA
GTTTAAGGGGAACACGTGCAGGTTTGTTCTATAGATCAATTACATGTCACAGGGGTTTGGTGTACATATTATTTCATTACCCAGGTAATA
AGCATAGTACCCAATAGATACTTTTTTGATACCCCACCCTCCTCCACCCTCTACCCTCAAGTAGTCCCTGGTGTCTGTTGTTCCCTTTTT
TGTGTCCATGGGTACTCAATGTTTAGCTCTCCCTTATACGTGAGAACATGTGATGTTTGGTTTTCTGTTCATGTGTTGGTTTGCTTAGGG
TAATGGCCTCCAGCTCCATCCATGTTGCTGCAAAGACATGATCTCATTCTTTTTTTATGGCTGCATAGTATTCCATGGTGTATATGTACT
ATGTTTTCTTTATCCAGTCTACTGTTGATGGGCATTTAGGTTGATTCCATGTCTTTGCTATTGTGAATAGTGCTGCAATGAATATATACA

>87882_87882_8_STXBP2-TRIM4_STXBP2_chr19_7705889_ENST00000221283_TRIM4_chr7_99490369_ENST00000355947_length(amino acids)=145AA_BP=
MAPSGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVEDINKRREPIPSLEAIYLLSPTEKSVQALIKD

--------------------------------------------------------------
>87882_87882_9_STXBP2-TRIM4_STXBP2_chr19_7705889_ENST00000414284_TRIM4_chr7_99490369_ENST00000349062_length(transcript)=2777nt_BP=443nt
GGCGGCGGCGCCCCTCGGGGAAGATGGCGCCCTCGGGGCTGAAGGCGGTGGTGGGGGAAAAAATTCTGAGCGGAGTTATTCGGAGTGTCA
AGAAGGATGGGGAGTGGAAGGTGCTTATCATGGATCACCCAAGCATGCGCATCTTGTCTTCCTGCTGCAAAATGTCAGATATCCTGGCTG
AGGGCATCACCATTGTTGAAGACATCAACAAACGGCGGGAACCCATTCCCAGTCTGGAGGCCATTTATTTGCTGAGCCCCACGGAGAAGG
CCCTGATCAAAGACTTCCAGGGGACCCCGACTTTCACCTACAAAGCGGCCCATATCTTCTTCACCGACACCTGCCCCGAGCCCCTGTTCA
GTGAGCTAGGCCGCTCTCGTCTGGCAAAGGTGGTGAAGACGTTGAAGGAGATTCACCTTGCCTTCCTCCCCTACGAGGCCCAGTGGCTGT
AAACCTAGCTGAAGACACAGCTCATCCCAAACTCGTCTTCTCCCAGGAAGGGAGATACGTGAAAAATACAGCATCAGCCAGTTCTTGGCC
AGTGTTTTCTTCAGCATGGAACTACTTTGCTGGATGGAGGAATCCTCAGAAGACTGCTTTTGTAGAGAGATTTCAGCACTTACCCTGTGT
TCTGGGAAAAAACGTTTTCACCTCAGGGAAACATTACTGGGAAGTTGAGAGTAGAGATAGTCTGGAGGTTGCTGTTGGGGTGTGTCGGGA
GGACGTCATGGGAATTACTGATCGTTCAAAAATGTCCCCAGATGTGGGCATCTGGGCGATTTATTGGAGTGCTGCTGGCTATTGGCCCTT
GATAGGCTTCCCTGGAACTCCCACCCAGCAAGAGCCAGCTCTCCACCGAGTGGGGGTTTACCTGGATCGTGGGACTGGGAATGTCTCCTT
CTACAGCGCTGTGGACGGAGTGCACCTGCACACCTTTTCTTGTTCTTCTGTCTCACGCCTCCGGCCATTTTTTTGGTTGAGTCCATTAGC
ATCTTTAGTCATTCCACCAGTGACTGATAGGAAATGAGGCTTTTCTTCCCCTGACCAAAACTCCTTCCCTGTAGTCCAGCTGAGGGACAC
ACATCCCTGGGCCCTCTTCTGCCCTTCATGTCTCTATCCTGGATGGTCCATCTTCTGGGTCTCCCTAACGGTACCGTTTGGTATCTGCCC
TTTGTGTGCTTCACAAGAGGCAGTCCCATGGGAGGTGGGTCTGGCCAATGGAGATGGGACAGGAAATTTTCCAAGACGCTTTTGGGAAAT
CTTTTTGTAGCTTTTAAAGAGATGTGCGGGGAAGACATATGGATGTTAGCAGCCATATTGGAACTGAGAACACAGGAATGGTGGAAAGGT
AGAAGAAACAGAGTTTTTGTTGCCGTTGTGAAATTGTTGAAATTTCCTTCATGCCAAGCTTCTTGTTATATGAGATAATTACGCCCTTAT
TGTATAAGACAATTTTAGTTGTATTTGGTTACTTGCAGCCTGAAGTACCGTAACTGCACTAAAGGGACGTAGTGTGAACATCCCGCAGTA
TAGGCTTAAGTCACTTTTGTGAAATTTGACAAAGGCATAGAATCTTTTTCTATCCAGTCAGGCATTGCCTATTCTTTCCAGTAACTACTG
ATTCCCCCACTTTTCTGTCTTAGAAAATTGTGGGAATCCCCCCTCACTCTGCCTATGTTGCACTCTCTCTCTTCCCAACCATAACTCTGC
CCTCAGCTATTAACTGTGCTGTGTATTTATCAAGTTGGTATGTTGTATGTACAGTGTTATTCATGTCATCATGAGAATGTTGAACGCTTG
TTAAATATCTTTTGCTAGCCTCTTCATATGCTGTTGCATATGACTCTCATCACAACTCAGTGAGATGGAAAGTCAAATCCTATTTGTACA
AATGAGAAAACTGAACTCTTTAGAGTAACTAGCTCAGTATTGGCCAGCTGGTAAATGGCAGTGTTGGGATTAAAATCCAGTTCTTATCTA
CTCTCCCTTTATTCAGAAGCATTTATTGGATGTTGATCTTTGTTTCAGGTTTTGATTTTGTTACTTTTTTATACTGTGTATATTTTCCTC
AGTCTACCCTTCTGCTCTAGATTGTCTGGACTCAGGAGATTGTGGCAGTTACTGGATAGTTATTTTTAAGATAATGATTGCTTTTCTCTG
TTTATATAAGTCATGTGTACTTATTGTAGAAAGTTTGTAAGATGCAAAAAGTATAAAAATTAAAGTTATGCACTACTAACATTTCAATAT
ATTTTCTCCCAGATTTTCAGTAAAGACTTTCAGGCAGTGATTTAACGAGGATTTTATTTTAACTTATATTTTAGTTTAAGGGGAACACGT
GCAGGTTTGTTCTATAGATCAATTACATGTCACAGGGGTTTGGTGTACATATTATTTCATTACCCAGGTAATAAGCATAGTACCCAATAG
ATACTTTTTTGATACCCCACCCTCCTCCACCCTCTACCCTCAAGTAGTCCCTGGTGTCTGTTGTTCCCTTTTTTGTGTCCATGGGTACTC
AATGTTTAGCTCTCCCTTATACGTGAGAACATGTGATGTTTGGTTTTCTGTTCATGTGTTGGTTTGCTTAGGGTAATGGCCTCCAGCTCC
ATCCATGTTGCTGCAAAGACATGATCTCATTCTTTTTTTATGGCTGCATAGTATTCCATGGTGTATATGTACTATGTTTTCTTTATCCAG

>87882_87882_9_STXBP2-TRIM4_STXBP2_chr19_7705889_ENST00000414284_TRIM4_chr7_99490369_ENST00000349062_length(amino acids)=142AA_BP=
MAPSGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVEDINKRREPIPSLEAIYLLSPTEKALIKDFQG

--------------------------------------------------------------
>87882_87882_10_STXBP2-TRIM4_STXBP2_chr19_7705889_ENST00000414284_TRIM4_chr7_99490369_ENST00000355947_length(transcript)=2777nt_BP=443nt
GGCGGCGGCGCCCCTCGGGGAAGATGGCGCCCTCGGGGCTGAAGGCGGTGGTGGGGGAAAAAATTCTGAGCGGAGTTATTCGGAGTGTCA
AGAAGGATGGGGAGTGGAAGGTGCTTATCATGGATCACCCAAGCATGCGCATCTTGTCTTCCTGCTGCAAAATGTCAGATATCCTGGCTG
AGGGCATCACCATTGTTGAAGACATCAACAAACGGCGGGAACCCATTCCCAGTCTGGAGGCCATTTATTTGCTGAGCCCCACGGAGAAGG
CCCTGATCAAAGACTTCCAGGGGACCCCGACTTTCACCTACAAAGCGGCCCATATCTTCTTCACCGACACCTGCCCCGAGCCCCTGTTCA
GTGAGCTAGGCCGCTCTCGTCTGGCAAAGGTGGTGAAGACGTTGAAGGAGATTCACCTTGCCTTCCTCCCCTACGAGGCCCAGTGGCTGT
AAACCTAGCTGAAGACACAGCTCATCCCAAACTCGTCTTCTCCCAGGAAGGGAGATACGTGAAAAATACAGCATCAGCCAGTTCTTGGCC
AGTGTTTTCTTCAGCATGGAACTACTTTGCTGGATGGAGGAATCCTCAGAAGACTGCTTTTGTAGAGAGATTTCAGCACTTACCCTGTGT
TCTGGGAAAAAACGTTTTCACCTCAGGGAAACATTACTGGGAAGTTGAGAGTAGAGATAGTCTGGAGGTTGCTGTTGGGGTGTGTCGGGA
GGACGTCATGGGAATTACTGATCGTTCAAAAATGTCCCCAGATGTGGGCATCTGGGCGATTTATTGGAGTGCTGCTGGCTATTGGCCCTT
GATAGGCTTCCCTGGAACTCCCACCCAGCAAGAGCCAGCTCTCCACCGAGTGGGGGTTTACCTGGATCGTGGGACTGGGAATGTCTCCTT
CTACAGCGCTGTGGACGGAGTGCACCTGCACACCTTTTCTTGTTCTTCTGTCTCACGCCTCCGGCCATTTTTTTGGTTGAGTCCATTAGC
ATCTTTAGTCATTCCACCAGTGACTGATAGGAAATGAGGCTTTTCTTCCCCTGACCAAAACTCCTTCCCTGTAGTCCAGCTGAGGGACAC
ACATCCCTGGGCCCTCTTCTGCCCTTCATGTCTCTATCCTGGATGGTCCATCTTCTGGGTCTCCCTAACGGTACCGTTTGGTATCTGCCC
TTTGTGTGCTTCACAAGAGGCAGTCCCATGGGAGGTGGGTCTGGCCAATGGAGATGGGACAGGAAATTTTCCAAGACGCTTTTGGGAAAT
CTTTTTGTAGCTTTTAAAGAGATGTGCGGGGAAGACATATGGATGTTAGCAGCCATATTGGAACTGAGAACACAGGAATGGTGGAAAGGT
AGAAGAAACAGAGTTTTTGTTGCCGTTGTGAAATTGTTGAAATTTCCTTCATGCCAAGCTTCTTGTTATATGAGATAATTACGCCCTTAT
TGTATAAGACAATTTTAGTTGTATTTGGTTACTTGCAGCCTGAAGTACCGTAACTGCACTAAAGGGACGTAGTGTGAACATCCCGCAGTA
TAGGCTTAAGTCACTTTTGTGAAATTTGACAAAGGCATAGAATCTTTTTCTATCCAGTCAGGCATTGCCTATTCTTTCCAGTAACTACTG
ATTCCCCCACTTTTCTGTCTTAGAAAATTGTGGGAATCCCCCCTCACTCTGCCTATGTTGCACTCTCTCTCTTCCCAACCATAACTCTGC
CCTCAGCTATTAACTGTGCTGTGTATTTATCAAGTTGGTATGTTGTATGTACAGTGTTATTCATGTCATCATGAGAATGTTGAACGCTTG
TTAAATATCTTTTGCTAGCCTCTTCATATGCTGTTGCATATGACTCTCATCACAACTCAGTGAGATGGAAAGTCAAATCCTATTTGTACA
AATGAGAAAACTGAACTCTTTAGAGTAACTAGCTCAGTATTGGCCAGCTGGTAAATGGCAGTGTTGGGATTAAAATCCAGTTCTTATCTA
CTCTCCCTTTATTCAGAAGCATTTATTGGATGTTGATCTTTGTTTCAGGTTTTGATTTTGTTACTTTTTTATACTGTGTATATTTTCCTC
AGTCTACCCTTCTGCTCTAGATTGTCTGGACTCAGGAGATTGTGGCAGTTACTGGATAGTTATTTTTAAGATAATGATTGCTTTTCTCTG
TTTATATAAGTCATGTGTACTTATTGTAGAAAGTTTGTAAGATGCAAAAAGTATAAAAATTAAAGTTATGCACTACTAACATTTCAATAT
ATTTTCTCCCAGATTTTCAGTAAAGACTTTCAGGCAGTGATTTAACGAGGATTTTATTTTAACTTATATTTTAGTTTAAGGGGAACACGT
GCAGGTTTGTTCTATAGATCAATTACATGTCACAGGGGTTTGGTGTACATATTATTTCATTACCCAGGTAATAAGCATAGTACCCAATAG
ATACTTTTTTGATACCCCACCCTCCTCCACCCTCTACCCTCAAGTAGTCCCTGGTGTCTGTTGTTCCCTTTTTTGTGTCCATGGGTACTC
AATGTTTAGCTCTCCCTTATACGTGAGAACATGTGATGTTTGGTTTTCTGTTCATGTGTTGGTTTGCTTAGGGTAATGGCCTCCAGCTCC
ATCCATGTTGCTGCAAAGACATGATCTCATTCTTTTTTTATGGCTGCATAGTATTCCATGGTGTATATGTACTATGTTTTCTTTATCCAG

>87882_87882_10_STXBP2-TRIM4_STXBP2_chr19_7705889_ENST00000414284_TRIM4_chr7_99490369_ENST00000355947_length(amino acids)=142AA_BP=
MAPSGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVEDINKRREPIPSLEAIYLLSPTEKALIKDFQG

--------------------------------------------------------------
>87882_87882_11_STXBP2-TRIM4_STXBP2_chr19_7705889_ENST00000441779_TRIM4_chr7_99490369_ENST00000349062_length(transcript)=2833nt_BP=499nt
ACACACCCGGAAGCGGCGGCGGCGCCCCTCGGGGAAGATGGCGCCCTCGGGGCTGAAGGCGGTGGTGGGGGAAAAAATTCTGAGCGGAGT
TATTCGGAGTGTCAAGAAGGATGGGGAGTGGAAGGTGCTTATCATGGATCACCCAAGCATGCGCATCTTGTCTTCCTGCTGCAAAATGTC
AGATATCCTGGCTGAGGGCATCACCATTGTTGAAGACATCAACAAACGGCGGGAACCCATTCCCAGTCTGGAGGCCATTTATTTGCTGAG
CCCCACGGAGAAGGCTCAGGCCCAGAGAGTGATCCACCTTCCCCAGTCGGTTCAGGCCCTGATCAAAGACTTCCAGGGGACCCCGACTTT
CACCTACAAAGCGGCCCATATCTTCTTCACCGACACCTGCCCCGAGCCCCTGTTCAGTGAGCTAGGCCGCTCTCGTCTGGCAAAGGTGGT
GAAGACGTTGAAGGAGATTCACCTTGCCTTCCTCCCCTACGAGGCCCAGTGGCTGTAAACCTAGCTGAAGACACAGCTCATCCCAAACTC
GTCTTCTCCCAGGAAGGGAGATACGTGAAAAATACAGCATCAGCCAGTTCTTGGCCAGTGTTTTCTTCAGCATGGAACTACTTTGCTGGA
TGGAGGAATCCTCAGAAGACTGCTTTTGTAGAGAGATTTCAGCACTTACCCTGTGTTCTGGGAAAAAACGTTTTCACCTCAGGGAAACAT
TACTGGGAAGTTGAGAGTAGAGATAGTCTGGAGGTTGCTGTTGGGGTGTGTCGGGAGGACGTCATGGGAATTACTGATCGTTCAAAAATG
TCCCCAGATGTGGGCATCTGGGCGATTTATTGGAGTGCTGCTGGCTATTGGCCCTTGATAGGCTTCCCTGGAACTCCCACCCAGCAAGAG
CCAGCTCTCCACCGAGTGGGGGTTTACCTGGATCGTGGGACTGGGAATGTCTCCTTCTACAGCGCTGTGGACGGAGTGCACCTGCACACC
TTTTCTTGTTCTTCTGTCTCACGCCTCCGGCCATTTTTTTGGTTGAGTCCATTAGCATCTTTAGTCATTCCACCAGTGACTGATAGGAAA
TGAGGCTTTTCTTCCCCTGACCAAAACTCCTTCCCTGTAGTCCAGCTGAGGGACACACATCCCTGGGCCCTCTTCTGCCCTTCATGTCTC
TATCCTGGATGGTCCATCTTCTGGGTCTCCCTAACGGTACCGTTTGGTATCTGCCCTTTGTGTGCTTCACAAGAGGCAGTCCCATGGGAG
GTGGGTCTGGCCAATGGAGATGGGACAGGAAATTTTCCAAGACGCTTTTGGGAAATCTTTTTGTAGCTTTTAAAGAGATGTGCGGGGAAG
ACATATGGATGTTAGCAGCCATATTGGAACTGAGAACACAGGAATGGTGGAAAGGTAGAAGAAACAGAGTTTTTGTTGCCGTTGTGAAAT
TGTTGAAATTTCCTTCATGCCAAGCTTCTTGTTATATGAGATAATTACGCCCTTATTGTATAAGACAATTTTAGTTGTATTTGGTTACTT
GCAGCCTGAAGTACCGTAACTGCACTAAAGGGACGTAGTGTGAACATCCCGCAGTATAGGCTTAAGTCACTTTTGTGAAATTTGACAAAG
GCATAGAATCTTTTTCTATCCAGTCAGGCATTGCCTATTCTTTCCAGTAACTACTGATTCCCCCACTTTTCTGTCTTAGAAAATTGTGGG
AATCCCCCCTCACTCTGCCTATGTTGCACTCTCTCTCTTCCCAACCATAACTCTGCCCTCAGCTATTAACTGTGCTGTGTATTTATCAAG
TTGGTATGTTGTATGTACAGTGTTATTCATGTCATCATGAGAATGTTGAACGCTTGTTAAATATCTTTTGCTAGCCTCTTCATATGCTGT
TGCATATGACTCTCATCACAACTCAGTGAGATGGAAAGTCAAATCCTATTTGTACAAATGAGAAAACTGAACTCTTTAGAGTAACTAGCT
CAGTATTGGCCAGCTGGTAAATGGCAGTGTTGGGATTAAAATCCAGTTCTTATCTACTCTCCCTTTATTCAGAAGCATTTATTGGATGTT
GATCTTTGTTTCAGGTTTTGATTTTGTTACTTTTTTATACTGTGTATATTTTCCTCAGTCTACCCTTCTGCTCTAGATTGTCTGGACTCA
GGAGATTGTGGCAGTTACTGGATAGTTATTTTTAAGATAATGATTGCTTTTCTCTGTTTATATAAGTCATGTGTACTTATTGTAGAAAGT
TTGTAAGATGCAAAAAGTATAAAAATTAAAGTTATGCACTACTAACATTTCAATATATTTTCTCCCAGATTTTCAGTAAAGACTTTCAGG
CAGTGATTTAACGAGGATTTTATTTTAACTTATATTTTAGTTTAAGGGGAACACGTGCAGGTTTGTTCTATAGATCAATTACATGTCACA
GGGGTTTGGTGTACATATTATTTCATTACCCAGGTAATAAGCATAGTACCCAATAGATACTTTTTTGATACCCCACCCTCCTCCACCCTC
TACCCTCAAGTAGTCCCTGGTGTCTGTTGTTCCCTTTTTTGTGTCCATGGGTACTCAATGTTTAGCTCTCCCTTATACGTGAGAACATGT
GATGTTTGGTTTTCTGTTCATGTGTTGGTTTGCTTAGGGTAATGGCCTCCAGCTCCATCCATGTTGCTGCAAAGACATGATCTCATTCTT
TTTTTATGGCTGCATAGTATTCCATGGTGTATATGTACTATGTTTTCTTTATCCAGTCTACTGTTGATGGGCATTTAGGTTGATTCCATG

>87882_87882_11_STXBP2-TRIM4_STXBP2_chr19_7705889_ENST00000441779_TRIM4_chr7_99490369_ENST00000349062_length(amino acids)=156AA_BP=
MAPSGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVEDINKRREPIPSLEAIYLLSPTEKAQAQRVIH

--------------------------------------------------------------
>87882_87882_12_STXBP2-TRIM4_STXBP2_chr19_7705889_ENST00000441779_TRIM4_chr7_99490369_ENST00000355947_length(transcript)=2833nt_BP=499nt
ACACACCCGGAAGCGGCGGCGGCGCCCCTCGGGGAAGATGGCGCCCTCGGGGCTGAAGGCGGTGGTGGGGGAAAAAATTCTGAGCGGAGT
TATTCGGAGTGTCAAGAAGGATGGGGAGTGGAAGGTGCTTATCATGGATCACCCAAGCATGCGCATCTTGTCTTCCTGCTGCAAAATGTC
AGATATCCTGGCTGAGGGCATCACCATTGTTGAAGACATCAACAAACGGCGGGAACCCATTCCCAGTCTGGAGGCCATTTATTTGCTGAG
CCCCACGGAGAAGGCTCAGGCCCAGAGAGTGATCCACCTTCCCCAGTCGGTTCAGGCCCTGATCAAAGACTTCCAGGGGACCCCGACTTT
CACCTACAAAGCGGCCCATATCTTCTTCACCGACACCTGCCCCGAGCCCCTGTTCAGTGAGCTAGGCCGCTCTCGTCTGGCAAAGGTGGT
GAAGACGTTGAAGGAGATTCACCTTGCCTTCCTCCCCTACGAGGCCCAGTGGCTGTAAACCTAGCTGAAGACACAGCTCATCCCAAACTC
GTCTTCTCCCAGGAAGGGAGATACGTGAAAAATACAGCATCAGCCAGTTCTTGGCCAGTGTTTTCTTCAGCATGGAACTACTTTGCTGGA
TGGAGGAATCCTCAGAAGACTGCTTTTGTAGAGAGATTTCAGCACTTACCCTGTGTTCTGGGAAAAAACGTTTTCACCTCAGGGAAACAT
TACTGGGAAGTTGAGAGTAGAGATAGTCTGGAGGTTGCTGTTGGGGTGTGTCGGGAGGACGTCATGGGAATTACTGATCGTTCAAAAATG
TCCCCAGATGTGGGCATCTGGGCGATTTATTGGAGTGCTGCTGGCTATTGGCCCTTGATAGGCTTCCCTGGAACTCCCACCCAGCAAGAG
CCAGCTCTCCACCGAGTGGGGGTTTACCTGGATCGTGGGACTGGGAATGTCTCCTTCTACAGCGCTGTGGACGGAGTGCACCTGCACACC
TTTTCTTGTTCTTCTGTCTCACGCCTCCGGCCATTTTTTTGGTTGAGTCCATTAGCATCTTTAGTCATTCCACCAGTGACTGATAGGAAA
TGAGGCTTTTCTTCCCCTGACCAAAACTCCTTCCCTGTAGTCCAGCTGAGGGACACACATCCCTGGGCCCTCTTCTGCCCTTCATGTCTC
TATCCTGGATGGTCCATCTTCTGGGTCTCCCTAACGGTACCGTTTGGTATCTGCCCTTTGTGTGCTTCACAAGAGGCAGTCCCATGGGAG
GTGGGTCTGGCCAATGGAGATGGGACAGGAAATTTTCCAAGACGCTTTTGGGAAATCTTTTTGTAGCTTTTAAAGAGATGTGCGGGGAAG
ACATATGGATGTTAGCAGCCATATTGGAACTGAGAACACAGGAATGGTGGAAAGGTAGAAGAAACAGAGTTTTTGTTGCCGTTGTGAAAT
TGTTGAAATTTCCTTCATGCCAAGCTTCTTGTTATATGAGATAATTACGCCCTTATTGTATAAGACAATTTTAGTTGTATTTGGTTACTT
GCAGCCTGAAGTACCGTAACTGCACTAAAGGGACGTAGTGTGAACATCCCGCAGTATAGGCTTAAGTCACTTTTGTGAAATTTGACAAAG
GCATAGAATCTTTTTCTATCCAGTCAGGCATTGCCTATTCTTTCCAGTAACTACTGATTCCCCCACTTTTCTGTCTTAGAAAATTGTGGG
AATCCCCCCTCACTCTGCCTATGTTGCACTCTCTCTCTTCCCAACCATAACTCTGCCCTCAGCTATTAACTGTGCTGTGTATTTATCAAG
TTGGTATGTTGTATGTACAGTGTTATTCATGTCATCATGAGAATGTTGAACGCTTGTTAAATATCTTTTGCTAGCCTCTTCATATGCTGT
TGCATATGACTCTCATCACAACTCAGTGAGATGGAAAGTCAAATCCTATTTGTACAAATGAGAAAACTGAACTCTTTAGAGTAACTAGCT
CAGTATTGGCCAGCTGGTAAATGGCAGTGTTGGGATTAAAATCCAGTTCTTATCTACTCTCCCTTTATTCAGAAGCATTTATTGGATGTT
GATCTTTGTTTCAGGTTTTGATTTTGTTACTTTTTTATACTGTGTATATTTTCCTCAGTCTACCCTTCTGCTCTAGATTGTCTGGACTCA
GGAGATTGTGGCAGTTACTGGATAGTTATTTTTAAGATAATGATTGCTTTTCTCTGTTTATATAAGTCATGTGTACTTATTGTAGAAAGT
TTGTAAGATGCAAAAAGTATAAAAATTAAAGTTATGCACTACTAACATTTCAATATATTTTCTCCCAGATTTTCAGTAAAGACTTTCAGG
CAGTGATTTAACGAGGATTTTATTTTAACTTATATTTTAGTTTAAGGGGAACACGTGCAGGTTTGTTCTATAGATCAATTACATGTCACA
GGGGTTTGGTGTACATATTATTTCATTACCCAGGTAATAAGCATAGTACCCAATAGATACTTTTTTGATACCCCACCCTCCTCCACCCTC
TACCCTCAAGTAGTCCCTGGTGTCTGTTGTTCCCTTTTTTGTGTCCATGGGTACTCAATGTTTAGCTCTCCCTTATACGTGAGAACATGT
GATGTTTGGTTTTCTGTTCATGTGTTGGTTTGCTTAGGGTAATGGCCTCCAGCTCCATCCATGTTGCTGCAAAGACATGATCTCATTCTT
TTTTTATGGCTGCATAGTATTCCATGGTGTATATGTACTATGTTTTCTTTATCCAGTCTACTGTTGATGGGCATTTAGGTTGATTCCATG

>87882_87882_12_STXBP2-TRIM4_STXBP2_chr19_7705889_ENST00000441779_TRIM4_chr7_99490369_ENST00000355947_length(amino acids)=156AA_BP=
MAPSGLKAVVGEKILSGVIRSVKKDGEWKVLIMDHPSMRILSSCCKMSDILAEGITIVEDINKRREPIPSLEAIYLLSPTEKAQAQRVIH

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for STXBP2-TRIM4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for STXBP2-TRIM4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for STXBP2-TRIM4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource