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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:STXBP5-TNFRSF19 (FusionGDB2 ID:87907)

Fusion Gene Summary for STXBP5-TNFRSF19

check button Fusion gene summary
Fusion gene informationFusion gene name: STXBP5-TNFRSF19
Fusion gene ID: 87907
HgeneTgene
Gene symbol

STXBP5

TNFRSF19

Gene ID

134957

55504

Gene namesyntaxin binding protein 5TNF receptor superfamily member 19
SynonymsLGL3|LLGL3|Nbla04300TAJ|TAJ-alpha|TRADE|TROY
Cytomap

6q24.3

13q12.12

Type of geneprotein-codingprotein-coding
Descriptionsyntaxin-binding protein 5lethal(2) giant larvae protein homolog 3putative protein product of Nbla04300tomosyntomosyn-1tumor necrosis factor receptor superfamily member 19toxicity and JNK inducer
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000321680, ENST00000179882, 
ENST00000367480, ENST00000367481, 
ENST00000546097, 		ENST00000382258, 
ENST00000464735, ENST00000248484, 
ENST00000382263, ENST00000403372, 
Fusion gene scores* DoF score7 X 9 X 4=2527 X 6 X 6=252
# samples 98
** MAII scorelog2(9/252*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/252*10)=-1.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: STXBP5 [Title/Abstract] AND TNFRSF19 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSTXBP5(147660520)-TNFRSF19(24247511), # samples:2
Anticipated loss of major functional domain due to fusion event.STXBP5-TNFRSF19 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
STXBP5-TNFRSF19 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
STXBP5-TNFRSF19 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across STXBP5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TNFRSF19 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-PC-A5DM-01ASTXBP5chr6

147660520

-TNFRSF19chr13

24247511

+
ChimerDB4SARCTCGA-PC-A5DM-01ASTXBP5chr6

147660520

+TNFRSF19chr13

24247511

+


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Fusion Gene ORF analysis for STXBP5-TNFRSF19

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000321680ENST00000382258STXBP5chr6

147660520

+TNFRSF19chr13

24247511

+
5CDS-intronENST00000321680ENST00000464735STXBP5chr6

147660520

+TNFRSF19chr13

24247511

+
Frame-shiftENST00000321680ENST00000248484STXBP5chr6

147660520

+TNFRSF19chr13

24247511

+
Frame-shiftENST00000321680ENST00000382263STXBP5chr6

147660520

+TNFRSF19chr13

24247511

+
In-frameENST00000321680ENST00000403372STXBP5chr6

147660520

+TNFRSF19chr13

24247511

+
intron-3CDSENST00000179882ENST00000248484STXBP5chr6

147660520

+TNFRSF19chr13

24247511

+
intron-3CDSENST00000179882ENST00000382263STXBP5chr6

147660520

+TNFRSF19chr13

24247511

+
intron-3CDSENST00000179882ENST00000403372STXBP5chr6

147660520

+TNFRSF19chr13

24247511

+
intron-3CDSENST00000367480ENST00000248484STXBP5chr6

147660520

+TNFRSF19chr13

24247511

+
intron-3CDSENST00000367480ENST00000382263STXBP5chr6

147660520

+TNFRSF19chr13

24247511

+
intron-3CDSENST00000367480ENST00000403372STXBP5chr6

147660520

+TNFRSF19chr13

24247511

+
intron-3CDSENST00000367481ENST00000248484STXBP5chr6

147660520

+TNFRSF19chr13

24247511

+
intron-3CDSENST00000367481ENST00000382263STXBP5chr6

147660520

+TNFRSF19chr13

24247511

+
intron-3CDSENST00000367481ENST00000403372STXBP5chr6

147660520

+TNFRSF19chr13

24247511

+
intron-3CDSENST00000546097ENST00000248484STXBP5chr6

147660520

+TNFRSF19chr13

24247511

+
intron-3CDSENST00000546097ENST00000382263STXBP5chr6

147660520

+TNFRSF19chr13

24247511

+
intron-3CDSENST00000546097ENST00000403372STXBP5chr6

147660520

+TNFRSF19chr13

24247511

+
intron-intronENST00000179882ENST00000382258STXBP5chr6

147660520

+TNFRSF19chr13

24247511

+
intron-intronENST00000179882ENST00000464735STXBP5chr6

147660520

+TNFRSF19chr13

24247511

+
intron-intronENST00000367480ENST00000382258STXBP5chr6

147660520

+TNFRSF19chr13

24247511

+
intron-intronENST00000367480ENST00000464735STXBP5chr6

147660520

+TNFRSF19chr13

24247511

+
intron-intronENST00000367481ENST00000382258STXBP5chr6

147660520

+TNFRSF19chr13

24247511

+
intron-intronENST00000367481ENST00000464735STXBP5chr6

147660520

+TNFRSF19chr13

24247511

+
intron-intronENST00000546097ENST00000382258STXBP5chr6

147660520

+TNFRSF19chr13

24247511

+
intron-intronENST00000546097ENST00000464735STXBP5chr6

147660520

+TNFRSF19chr13

24247511

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000321680STXBP5chr6147660520+ENST00000403372TNFRSF19chr1324247511+2382225402324774

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000321680ENST00000403372STXBP5chr6147660520+TNFRSF19chr1324247511+0.0013203090.9986797

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Fusion Genomic Features for STXBP5-TNFRSF19


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
STXBP5chr6147660520+TNFRSF19chr1324247510+0.0882781740.91172177
STXBP5chr6147660520+TNFRSF19chr1324247510+0.0882781740.91172177

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for STXBP5-TNFRSF19


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:147660520/chr13:24247511)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000321680+212822_277511152.0Compositional biasNote=Poly-Gln
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000321680+2128584_5907511152.0Compositional biasNote=Poly-Ser
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000321680+2128101_1407511152.0RepeatNote=WD 2
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000321680+2128145_1817511152.0RepeatNote=WD 3
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000321680+2128200_2347511152.0RepeatNote=WD 4
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000321680+2128240_2727511152.0RepeatNote=WD 5
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000321680+2128294_3367511152.0RepeatNote=WD 6
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000321680+2128344_3787511152.0RepeatNote=WD 7
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000321680+2128400_4777511152.0RepeatNote=WD 8
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000321680+2128505_6197511152.0RepeatNote=WD 9
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000321680+212861_947511152.0RepeatNote=WD 1
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000321680+2128633_6957511152.0RepeatNote=WD 10
TgeneTNFRSF19chr6:147660520chr13:24247511ENST0000038225809116_1490424.0RepeatNote=TNFR-Cys 3
TgeneTNFRSF19chr6:147660520chr13:24247511ENST000003822580933_720424.0RepeatNote=TNFR-Cys 1
TgeneTNFRSF19chr6:147660520chr13:24247511ENST000003822580974_1140424.0RepeatNote=TNFR-Cys 2
TgeneTNFRSF19chr6:147660520chr13:24247511ENST0000038225809192_4230424.0Topological domainCytoplasmic
TgeneTNFRSF19chr6:147660520chr13:24247511ENST000003822580930_1700424.0Topological domainExtracellular
TgeneTNFRSF19chr6:147660520chr13:24247511ENST0000038225809171_1910424.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367480+12522_2701099.0Compositional biasNote=Poly-Gln
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367480+125584_59001099.0Compositional biasNote=Poly-Ser
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367481+12622_2701116.0Compositional biasNote=Poly-Gln
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367481+126584_59001116.0Compositional biasNote=Poly-Ser
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000321680+21281086_11467511152.0Domainv-SNARE coiled-coil homology
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367480+1251086_114601099.0Domainv-SNARE coiled-coil homology
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367481+1261086_114601116.0Domainv-SNARE coiled-coil homology
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000321680+2128794_8517511152.0RepeatNote=WD 11
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000321680+2128860_9347511152.0RepeatNote=WD 12
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000321680+2128939_9837511152.0RepeatNote=WD 13
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000321680+2128997_10207511152.0RepeatNote=WD 14
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367480+125101_14001099.0RepeatNote=WD 2
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367480+125145_18101099.0RepeatNote=WD 3
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367480+125200_23401099.0RepeatNote=WD 4
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367480+125240_27201099.0RepeatNote=WD 5
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367480+125294_33601099.0RepeatNote=WD 6
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367480+125344_37801099.0RepeatNote=WD 7
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367480+125400_47701099.0RepeatNote=WD 8
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367480+125505_61901099.0RepeatNote=WD 9
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367480+12561_9401099.0RepeatNote=WD 1
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367480+125633_69501099.0RepeatNote=WD 10
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367480+125794_85101099.0RepeatNote=WD 11
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367480+125860_93401099.0RepeatNote=WD 12
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367480+125939_98301099.0RepeatNote=WD 13
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367480+125997_102001099.0RepeatNote=WD 14
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367481+126101_14001116.0RepeatNote=WD 2
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367481+126145_18101116.0RepeatNote=WD 3
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367481+126200_23401116.0RepeatNote=WD 4
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367481+126240_27201116.0RepeatNote=WD 5
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367481+126294_33601116.0RepeatNote=WD 6
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367481+126344_37801116.0RepeatNote=WD 7
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367481+126400_47701116.0RepeatNote=WD 8
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367481+126505_61901116.0RepeatNote=WD 9
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367481+12661_9401116.0RepeatNote=WD 1
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367481+126633_69501116.0RepeatNote=WD 10
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367481+126794_85101116.0RepeatNote=WD 11
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367481+126860_93401116.0RepeatNote=WD 12
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367481+126939_98301116.0RepeatNote=WD 13
HgeneSTXBP5chr6:147660520chr13:24247511ENST00000367481+126997_102001116.0RepeatNote=WD 14
TgeneTNFRSF19chr6:147660520chr13:24247511ENST00000248484810116_149415418.0RepeatNote=TNFR-Cys 3
TgeneTNFRSF19chr6:147660520chr13:24247511ENST0000024848481033_72415418.0RepeatNote=TNFR-Cys 1
TgeneTNFRSF19chr6:147660520chr13:24247511ENST0000024848481074_114415418.0RepeatNote=TNFR-Cys 2
TgeneTNFRSF19chr6:147660520chr13:24247511ENST00000382263810116_149415418.0RepeatNote=TNFR-Cys 3
TgeneTNFRSF19chr6:147660520chr13:24247511ENST0000038226381033_72415418.0RepeatNote=TNFR-Cys 1
TgeneTNFRSF19chr6:147660520chr13:24247511ENST0000038226381074_114415418.0RepeatNote=TNFR-Cys 2
TgeneTNFRSF19chr6:147660520chr13:24247511ENST0000040337268116_149283286.0RepeatNote=TNFR-Cys 3
TgeneTNFRSF19chr6:147660520chr13:24247511ENST000004033726833_72283286.0RepeatNote=TNFR-Cys 1
TgeneTNFRSF19chr6:147660520chr13:24247511ENST000004033726874_114283286.0RepeatNote=TNFR-Cys 2
TgeneTNFRSF19chr6:147660520chr13:24247511ENST00000248484810192_423415418.0Topological domainCytoplasmic
TgeneTNFRSF19chr6:147660520chr13:24247511ENST0000024848481030_170415418.0Topological domainExtracellular
TgeneTNFRSF19chr6:147660520chr13:24247511ENST00000382263810192_423415418.0Topological domainCytoplasmic
TgeneTNFRSF19chr6:147660520chr13:24247511ENST0000038226381030_170415418.0Topological domainExtracellular
TgeneTNFRSF19chr6:147660520chr13:24247511ENST0000040337268192_423283286.0Topological domainCytoplasmic
TgeneTNFRSF19chr6:147660520chr13:24247511ENST000004033726830_170283286.0Topological domainExtracellular
TgeneTNFRSF19chr6:147660520chr13:24247511ENST00000248484810171_191415418.0TransmembraneHelical
TgeneTNFRSF19chr6:147660520chr13:24247511ENST00000382263810171_191415418.0TransmembraneHelical
TgeneTNFRSF19chr6:147660520chr13:24247511ENST0000040337268171_191283286.0TransmembraneHelical


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Fusion Gene Sequence for STXBP5-TNFRSF19


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>87907_87907_1_STXBP5-TNFRSF19_STXBP5_chr6_147660520_ENST00000321680_TNFRSF19_chr13_24247511_ENST00000403372_length(transcript)=2382nt_BP=2254nt
ATGAGGAAATTCAACATCAGGAAGGTGCTGGACGGCCTGACCGCCGGCTCGTCCTCGGCGTCGCAGCAGCAACAGCAGCAGCATCCGCCT
GGGAACCGGGAGCCGGAGATCCAGGAAACGCTCCAGTCCGAGCACTTTCAGCTCTGCAAGACTGTTCGCCATGGATTTCCCTATCAACCC
TCAGCCCTGGCCTTTGATCCTGTACAGAAGATCCTGGCAGTGGGAACTCAGACTGGTGCTTTAAGGCTCTTTGGTCGTCCAGGAGTAGAA
TGTTATTGCCAGCATGACAGTGGAGCTGCAGTAATCCAGCTCCAGTTCCTGATTAATGAGGGAGCGCTTGTGAGTGCCTTGGCTGATGAC
ACCTTACACTTATGGAATTTACGTCAGAAGAGGCCTGCCATACTACATTCGCTTAAATTTTGCAGAGAAAGGGTTACATTTTGCCATCTG
CCTTTCCAGAGTAAGTGGCTCTATGTGGGCACTGAACGAGGTAATATACATATTGTCAATGTGGAGTCCTTCACACTCTCAGGCTACGTC
ATTATGTGGAATAAAGCCATTGAACTGTCATCTAAATCTCACCCAGGACCTGTGGTCCATATAAGTGATAATCCAATGGACGAGGGAAAG
CTTTTGATTGGCTTTGAATCTGGAACAGTAGTTTTATGGGACCTCAAATCAAAGAAAGCCGACTACAGATACACATATGATGAGGCTATC
CACTCTGTTGCTTGGCATCATGAAGGAAAACAATTTATTTGCAGTCATTCAGATGGCACCTTGACTATATGGAATGTAAGGTCCCCTGCT
AAACCAGTACAGACAATCACTCCACATGGAAAACAGTTAAAGGATGGGAAGAAGCCAGAACCATGCAAACCTATCCTCAAGGTGGAATTC
AAAACGACTAGATCTGGGGAGCCTTTTATTATTTTATCAGGAGGTTTGTCATATGATACTGTAGGAAGAAGACCTTGCTTAACAGTGATG
CATGGGAAAAGCACTGCTGTGCTAGAAATGGACTATTCAATTGTTGATTTTCTAACGCTGTGTGAAACACCATACCCAAATGATTTTCAA
GAACCATATGCTGTGGTTGTTCTTCTAGAAAAGGATTTAGTACTTATAGACCTTGCACAAAATGGATATCCTATATTTGAAAATCCCTAC
CCTTTGAGTATACATGAGTCCCCTGTTACATGTTGCGAATATTTTGCGGATTGTCCTGTGGACCTTATTCCTGCACTTTATTCTGTTGGA
GCTAGACAGAAACGTCAAGGTTACAGCAAAAAGGAATGGCCCATCAACGGAGGTAATTGGGGCTTGGGTGCTCAAAGTTACCCAGAAATA
ATTATTACAGGGCATGCTGATGGGTCAGTTAAGTTCTGGGATGCTTCTGCAATAACTCTACAAGTATTATATAAGCTAAAGACATCTAAA
GTATTTGAAAAGTCAAGAAATAAAGATGACAGGCCAAACACAGACATTGTAGATGAAGATCCATATGCCATTCAGATCATCTCCTGGTGT
CCAGAAAGTAGAATGCTGTGCATCGCTGGAGTTTCAGCTCATGTCATTATTTATAGATTCAGCAAGCAGGAAGTAATCACAGAAGTCATT
CCGATGCTTGAAGTTCGATTATTATATGAGATAAATGATGTGGAAACTCCGGAGGGTGAGCAGCCACCACCTTTGCCAACACCCGTGGGA
GGGTCCAACCCTCAGCCCATCCCTCCTCAGTCTCATCCATCTACCAGTAGCAGTTCATCTGATGGGCTTCGTGATAATGTACCTTGTTTA
AAAGTTAAAAACTCACCACTTAAACAGTCTCCAGGTTATCAAACAGAACTAGTTATTCAGTTGGTTTGGGTGGGTGGAGAACCACCACAA
CAAATAACCAGCCTGGCAGTCAATTCTTCCTATGGACTGGTGGTTTTTGGCAATTGCAATGGCATTGCTATGGTTGACTACCTCCAGAAA
GCAGTGCTGCTCAACCTGGGCACTATTGAATTATATGGCTCTAATGATCCTTATCGGAGAGAACCCCGATCTCCTCGTAAATCTCGACAG
CCTTCAGGAGCCGGTCTGTGTGATATTAGTGAAGGGACTGTTGTTCCAGAGGATCGCTGCAAATCTCCAACCTCTGGTTCTTCATCACCA
CACAATTCAGATGATGAACAAAAAATGAATAATTTTATAGAAAAGGTGAAGACCAAAAGCAGAAAGTTTTCCAAGATGGTAGCCAATGAT
ATAGGAAGCTTAAAGAACCTGCTTCTTTCTGCAGTAGAAGCGTGTGCTGGAACCCAAAGAGTACTCCTTTGTTAGGCTTATGGACTGAGC

>87907_87907_1_STXBP5-TNFRSF19_STXBP5_chr6_147660520_ENST00000321680_TNFRSF19_chr13_24247511_ENST00000403372_length(amino acids)=774AA_BP=751
MRKFNIRKVLDGLTAGSSSASQQQQQQHPPGNREPEIQETLQSEHFQLCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVE
CYCQHDSGAAVIQLQFLINEGALVSALADDTLHLWNLRQKRPAILHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVESFTLSGYV
IMWNKAIELSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEAIHSVAWHHEGKQFICSHSDGTLTIWNVRSPA
KPVQTITPHGKQLKDGKKPEPCKPILKVEFKTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETPYPNDFQ
EPYAVVVLLEKDLVLIDLAQNGYPIFENPYPLSIHESPVTCCEYFADCPVDLIPALYSVGARQKRQGYSKKEWPINGGNWGLGAQSYPEI
IITGHADGSVKFWDASAITLQVLYKLKTSKVFEKSRNKDDRPNTDIVDEDPYAIQIISWCPESRMLCIAGVSAHVIIYRFSKQEVITEVI
PMLEVRLLYEINDVETPEGEQPPPLPTPVGGSNPQPIPPQSHPSTSSSSSDGLRDNVPCLKVKNSPLKQSPGYQTELVIQLVWVGGEPPQ
QITSLAVNSSYGLVVFGNCNGIAMVDYLQKAVLLNLGTIELYGSNDPYRREPRSPRKSRQPSGAGLCDISEGTVVPEDRCKSPTSGSSSP

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Fusion Gene PPI Analysis for STXBP5-TNFRSF19


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for STXBP5-TNFRSF19


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for STXBP5-TNFRSF19


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource