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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SUFU-CYP26A1 (FusionGDB2 ID:87980)

Fusion Gene Summary for SUFU-CYP26A1

check button Fusion gene summary
Fusion gene informationFusion gene name: SUFU-CYP26A1
Fusion gene ID: 87980
HgeneTgene
Gene symbol

SUFU

CYP26A1

Gene ID

51684

1592

Gene nameSUFU negative regulator of hedgehog signalingcytochrome P450 family 26 subfamily A member 1
SynonymsJBTS32|PRO1280|SUFUH|SUFUXLCP26|CYP26|P450RAI|P450RAI1
Cytomap

10q24.32

10q23.33

Type of geneprotein-codingprotein-coding
Descriptionsuppressor of fused homologcytochrome P450 26A1P450, retinoic acid-inactivating, 1cytochrome P450 retinoic acid-inactivating 1cytochrome P450, family 26, subfamily A, polypeptide 1cytochrome P450, subfamily XXVIA, polypeptide 1cytochrome P450RAIhP450RAIretinoic acid 4-hydrox
Modification date2020031320200329
UniProtAcc.

O43174

Ensembl transtripts involved in fusion geneENST00000369899, ENST00000369902, 
ENST00000423559, ENST00000471000, 
ENST00000224356, ENST00000371531, 
ENST00000394139, 
Fusion gene scores* DoF score10 X 7 X 6=4203 X 3 X 3=27
# samples 134
** MAII scorelog2(13/420*10)=-1.69187770463767
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SUFU [Title/Abstract] AND CYP26A1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSUFU(104377185)-CYP26A1(94835583), # samples:3
Anticipated loss of major functional domain due to fusion event.SUFU-CYP26A1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
SUFU-CYP26A1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
SUFU-CYP26A1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSUFU

GO:0000122

negative regulation of transcription by RNA polymerase II

10564661

TgeneCYP26A1

GO:0006805

xenobiotic metabolic process

26937021

TgeneCYP26A1

GO:0034653

retinoic acid catabolic process

10823918

TgeneCYP26A1

GO:0042573

retinoic acid metabolic process

9716180|22020119


check buttonFusion gene breakpoints across SUFU (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CYP26A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-EJ-A7NN-01ASUFUchr10

104377185

-CYP26A1chr10

94835583

+
ChimerDB4PRADTCGA-EJ-A7NN-01ASUFUchr10

104377185

+CYP26A1chr10

94835583

+
ChimerDB4PRADTCGA-EJ-A7NNSUFUchr10

104377185

+CYP26A1chr10

94834065

+
ChimerDB4PRADTCGA-EJ-A7NNSUFUchr10

104377185

+CYP26A1chr10

94835583

+


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Fusion Gene ORF analysis for SUFU-CYP26A1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000369899ENST00000224356SUFUchr10

104377185

+CYP26A1chr10

94834065

+
5CDS-5UTRENST00000369899ENST00000371531SUFUchr10

104377185

+CYP26A1chr10

94834065

+
5CDS-5UTRENST00000369899ENST00000394139SUFUchr10

104377185

+CYP26A1chr10

94834065

+
5CDS-5UTRENST00000369902ENST00000224356SUFUchr10

104377185

+CYP26A1chr10

94834065

+
5CDS-5UTRENST00000369902ENST00000371531SUFUchr10

104377185

+CYP26A1chr10

94834065

+
5CDS-5UTRENST00000369902ENST00000394139SUFUchr10

104377185

+CYP26A1chr10

94834065

+
5CDS-5UTRENST00000423559ENST00000224356SUFUchr10

104377185

+CYP26A1chr10

94834065

+
5CDS-5UTRENST00000423559ENST00000371531SUFUchr10

104377185

+CYP26A1chr10

94834065

+
5CDS-5UTRENST00000423559ENST00000394139SUFUchr10

104377185

+CYP26A1chr10

94834065

+
Frame-shiftENST00000423559ENST00000224356SUFUchr10

104377185

+CYP26A1chr10

94835583

+
Frame-shiftENST00000423559ENST00000371531SUFUchr10

104377185

+CYP26A1chr10

94835583

+
Frame-shiftENST00000423559ENST00000394139SUFUchr10

104377185

+CYP26A1chr10

94835583

+
In-frameENST00000369899ENST00000224356SUFUchr10

104377185

+CYP26A1chr10

94835583

+
In-frameENST00000369899ENST00000371531SUFUchr10

104377185

+CYP26A1chr10

94835583

+
In-frameENST00000369899ENST00000394139SUFUchr10

104377185

+CYP26A1chr10

94835583

+
In-frameENST00000369902ENST00000224356SUFUchr10

104377185

+CYP26A1chr10

94835583

+
In-frameENST00000369902ENST00000371531SUFUchr10

104377185

+CYP26A1chr10

94835583

+
In-frameENST00000369902ENST00000394139SUFUchr10

104377185

+CYP26A1chr10

94835583

+
intron-3CDSENST00000471000ENST00000224356SUFUchr10

104377185

+CYP26A1chr10

94835583

+
intron-3CDSENST00000471000ENST00000371531SUFUchr10

104377185

+CYP26A1chr10

94835583

+
intron-3CDSENST00000471000ENST00000394139SUFUchr10

104377185

+CYP26A1chr10

94835583

+
intron-5UTRENST00000471000ENST00000224356SUFUchr10

104377185

+CYP26A1chr10

94834065

+
intron-5UTRENST00000471000ENST00000371531SUFUchr10

104377185

+CYP26A1chr10

94834065

+
intron-5UTRENST00000471000ENST00000394139SUFUchr10

104377185

+CYP26A1chr10

94834065

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369902SUFUchr10104377185+ENST00000371531CYP26A1chr1094835583+26721462972091664
ENST00000369902SUFUchr10104377185+ENST00000224356CYP26A1chr1094835583+26781462972091664
ENST00000369902SUFUchr10104377185+ENST00000394139CYP26A1chr1094835583+26781462972091664
ENST00000369899SUFUchr10104377185+ENST00000371531CYP26A1chr1094835583+26521442772071664
ENST00000369899SUFUchr10104377185+ENST00000224356CYP26A1chr1094835583+26581442772071664
ENST00000369899SUFUchr10104377185+ENST00000394139CYP26A1chr1094835583+26581442772071664

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369902ENST00000371531SUFUchr10104377185+CYP26A1chr1094835583+0.0016131550.99838686
ENST00000369902ENST00000224356SUFUchr10104377185+CYP26A1chr1094835583+0.0015875440.9984125
ENST00000369902ENST00000394139SUFUchr10104377185+CYP26A1chr1094835583+0.0015875440.9984125
ENST00000369899ENST00000371531SUFUchr10104377185+CYP26A1chr1094835583+0.0016069420.998393
ENST00000369899ENST00000224356SUFUchr10104377185+CYP26A1chr1094835583+0.0015776190.9984224
ENST00000369899ENST00000394139SUFUchr10104377185+CYP26A1chr1094835583+0.0015776190.9984224

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Fusion Genomic Features for SUFU-CYP26A1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SUFUchr10104377185+CYP26A1chr1094835582+0.105973670.89402634
SUFUchr10104377185+CYP26A1chr1094835582+0.105973670.89402634
SUFUchr10104377185+CYP26A1chr1094834064+0.0069576150.99304235
SUFUchr10104377185+CYP26A1chr1094835582+0.105973670.89402634
SUFUchr10104377185+CYP26A1chr1094835582+0.105973670.89402634
SUFUchr10104377185+CYP26A1chr1094834064+0.0069576150.99304235

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SUFU-CYP26A1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:104377185/chr10:94835583)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CYP26A1

O43174

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4 and C-18. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomers (PubMed:22020119, PubMed:9228017, PubMed:9716180). May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid (PubMed:26937021). {ECO:0000269|PubMed:22020119, ECO:0000269|PubMed:26937021, ECO:0000269|PubMed:9228017, ECO:0000269|PubMed:9716180}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSUFUchr10:104377185chr10:94835583ENST00000369899+1011279_360432434.0RegionIntrinsically disordered
HgeneSUFUchr10:104377185chr10:94835583ENST00000369902+1012279_360432485.0RegionIntrinsically disordered

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSUFUchr10:104377185chr10:94835583ENST00000423559+110279_3600482.0RegionIntrinsically disordered


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Fusion Gene Sequence for SUFU-CYP26A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>87980_87980_1_SUFU-CYP26A1_SUFU_chr10_104377185_ENST00000369899_CYP26A1_chr10_94835583_ENST00000224356_length(transcript)=2658nt_BP=1442nt
CGCCGTGCGCAGGCGCGGAGCTAGACCTCGCTGCAGCCCCCATCGCCTCGGGGAGTCTCACCCACCGAGTCCGCCCGCTGGCCCGTCAGT
GCTCTCCCCGTCGTTTGCCCTCTCCAGTTCCCCCAGTGCCTGCCCTACGCACCCCGATGGCGGAGCTGCGGCCTAGCGGCGCCCCCGGCC
CCACCGCGCCCCCGGCCCCTGGCCCGACTGCCCCCCCGGCCTTCGCTTCGCTCTTTCCCCCGGGACTGCACGCCATCTACGGAGAGTGCC
GCCGCCTTTACCCTGACCAGCCGAACCCGCTCCAGGTTACCGCTATCGTCAAGTACTGGTTGGGTGGCCCAGACCCCTTGGACTATGTTA
GCATGTACAGGAATGTGGGGAGCCCTTCTGCTAACATCCCCGAGCACTGGCACTACATCAGCTTCGGCCTGAGTGATCTCTATGGTGACA
ACAGAGTCCATGAGTTTACAGGAACAGATGGACCTAGTGGTTTTGGCTTTGAGTTGACCTTTCGTCTGAAGAGAGAAACTGGGGAGTCTG
CCCCACCAACATGGCCCGCAGAGTTAATGCAGGGCTTGGCACGATACGTGTTCCAGTCAGAGAACACCTTCTGCAGTGGGGACCATGTGT
CCTGGCACAGCCCTTTGGATAACAGTGAGTCAAGAATTCAGCACATGCTGCTGACAGAGGACCCACAGATGCAGCCCGTGCAGACACCCT
TTGGGGTAGTTACCTTCCTCCAGATCGTTGGTGTCTGCACTGAAGAGCTACACTCAGCCCAGCAGTGGAACGGGCAGGGCATCCTGGAGC
TGCTGCGGACAGTGCCTATTGCTGGCGGCCCCTGGCTGATAACTGACATGCGGAGGGGAGAGACCATATTTGAGATCGATCCACACCTGC
AAGAGAGAGTTGACAAAGGCATCGAGACAGATGGCTCCAACCTGAGTGGTGTCAGTGCCAAGTGTGCCTGGGATGACCTGAGCCGGCCCC
CCGAGGATGACGAGGACAGCCGGAGCATCTGCATCGGCACACAGCCCCGGCGACTCTCTGGCAAAGACACAGAGCAGATCCGGGAGACCC
TGAGGAGAGGACTCGAGATCAACAGCAAACCTGTCCTTCCACCAATCAACCCTCAGCGGCAGAATGGCCTCGCCCACGACCGGGCCCCGA
GCCGCAAAGACAGCCTGGAAAGTGACAGCTCCACGGCCATCATTCCCCATGAGCTGATTCGCACGCGGCAGCTTGAGAGCGTACATCTGA
AATTCAACCAGGAGTCCGGAGCCCTCATTCCTCTCTGCCTAAGGGGCAGGCTCCTGCATGGACGGCACTTTACATATAAAAGTATCACAG
GTGACATGGCCATCACGTTTGTCTCCACGGGAGTGGAAGGCGCCTTTGCCACTGAGGAGCATCCTTACGCGGCTCATGGACCCTGGTTAC
AAGCACTAAAGCAATCTTCAACCGAACTCCTCTTTGGAGGACACGAAACCACGGCCAGTGCAGCCACATCTCTGATCACTTACCTGGGGC
TCTACCCACATGTTCTCCAGAAAGTGCGAGAAGAGCTGAAGAGTAAGGGTTTACTTTGCAAGAGCAATCAAGACAACAAGTTGGACATGG
AAATTTTGGAACAACTTAAATACATCGGGTGTGTTATTAAGGAGACCCTTCGACTGAATCCCCCAGTTCCAGGAGGGTTTCGGGTTGCTC
TGAAGACTTTTGAATTAAATGGATACCAGATTCCCAAGGGCTGGAATGTTATCTACAGTATCTGTGATACTCATGATGTGGCAGAGATCT
TCACCAACAAGGAAGAATTTAATCCTGACCGATTCATGCTGCCTCACCCAGAGGATGCATCCAGGTTCAGCTTCATTCCATTTGGAGGAG
GCCTTAGGAGCTGTGTAGGCAAAGAATTTGCAAAAATTCTTCTCAAAATATTTACAGTGGAGCTGGCCAGGCATTGTGACTGGCAGCTTC
TAAATGGACCTCCTACAATGAAAACCAGTCCCACCGTGTATCCTGTGGACAATCTCCCTGCAAGATTCACCCATTTCCATGGGGAAATCT
GATGAGCTTGAATGTTCAAACCTGAGACTTATTGGAAGTGTACATATGAGTTTTTAAGGAGTGTTGTGTTGACTTTATATTTAATTTCTA
AATGTATATTATAATATTTATGTGTTTTGACTATACTACCACAATCTTTAAATATTAAAATAATGAATTTGTATCATTTCCAAATAAAGT
AAAATTTGAAGGTACTTTTCTGGTATTTTAAGATTCCTGTTGGGTAAAACTCACCAGTTTAGTATTTTCTTAGTGTATTTAACCAGATTT
TACAATGCCTACCTGGACTTATTTGTCATCTTTGCATCTGTTTTCTGTGAGAAGAAATCTTAGCTGTTTTTTATGTTAACAGTTATTAGA
AAATATATGTCTGTGTGTGTTATTCCAGACGTATCTCTGTAAATTCTTCTACAGTCACTTAGATTCCCTATTTGGAAAATTGATCCAAGT
TAATTTAATTTTTTTTTGGTTTGCTGTACTTTAGGGAAAGATGAACCTGAAAAGGTAACACTGAGAACTGTCACTCTAACCTCTCCAGCT

>87980_87980_1_SUFU-CYP26A1_SUFU_chr10_104377185_ENST00000369899_CYP26A1_chr10_94835583_ENST00000224356_length(amino acids)=664AA_BP=455
MARQCSPRRLPSPVPPVPALRTPMAELRPSGAPGPTAPPAPGPTAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGGPDP
LDYVSMYRNVGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSENTFCS
GDHVSWHSPLDNSESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHSAQQWNGQGILELLRTVPIAGGPWLITDMRRGETIFEI
DPHLQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDDEDSRSICIGTQPRRLSGKDTEQIRETLRRGLEINSKPVLPPINPQRQNGLAH
DRAPSRKDSLESDSSTAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAH
GPWLQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGG
FRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHC

--------------------------------------------------------------
>87980_87980_2_SUFU-CYP26A1_SUFU_chr10_104377185_ENST00000369899_CYP26A1_chr10_94835583_ENST00000371531_length(transcript)=2652nt_BP=1442nt
CGCCGTGCGCAGGCGCGGAGCTAGACCTCGCTGCAGCCCCCATCGCCTCGGGGAGTCTCACCCACCGAGTCCGCCCGCTGGCCCGTCAGT
GCTCTCCCCGTCGTTTGCCCTCTCCAGTTCCCCCAGTGCCTGCCCTACGCACCCCGATGGCGGAGCTGCGGCCTAGCGGCGCCCCCGGCC
CCACCGCGCCCCCGGCCCCTGGCCCGACTGCCCCCCCGGCCTTCGCTTCGCTCTTTCCCCCGGGACTGCACGCCATCTACGGAGAGTGCC
GCCGCCTTTACCCTGACCAGCCGAACCCGCTCCAGGTTACCGCTATCGTCAAGTACTGGTTGGGTGGCCCAGACCCCTTGGACTATGTTA
GCATGTACAGGAATGTGGGGAGCCCTTCTGCTAACATCCCCGAGCACTGGCACTACATCAGCTTCGGCCTGAGTGATCTCTATGGTGACA
ACAGAGTCCATGAGTTTACAGGAACAGATGGACCTAGTGGTTTTGGCTTTGAGTTGACCTTTCGTCTGAAGAGAGAAACTGGGGAGTCTG
CCCCACCAACATGGCCCGCAGAGTTAATGCAGGGCTTGGCACGATACGTGTTCCAGTCAGAGAACACCTTCTGCAGTGGGGACCATGTGT
CCTGGCACAGCCCTTTGGATAACAGTGAGTCAAGAATTCAGCACATGCTGCTGACAGAGGACCCACAGATGCAGCCCGTGCAGACACCCT
TTGGGGTAGTTACCTTCCTCCAGATCGTTGGTGTCTGCACTGAAGAGCTACACTCAGCCCAGCAGTGGAACGGGCAGGGCATCCTGGAGC
TGCTGCGGACAGTGCCTATTGCTGGCGGCCCCTGGCTGATAACTGACATGCGGAGGGGAGAGACCATATTTGAGATCGATCCACACCTGC
AAGAGAGAGTTGACAAAGGCATCGAGACAGATGGCTCCAACCTGAGTGGTGTCAGTGCCAAGTGTGCCTGGGATGACCTGAGCCGGCCCC
CCGAGGATGACGAGGACAGCCGGAGCATCTGCATCGGCACACAGCCCCGGCGACTCTCTGGCAAAGACACAGAGCAGATCCGGGAGACCC
TGAGGAGAGGACTCGAGATCAACAGCAAACCTGTCCTTCCACCAATCAACCCTCAGCGGCAGAATGGCCTCGCCCACGACCGGGCCCCGA
GCCGCAAAGACAGCCTGGAAAGTGACAGCTCCACGGCCATCATTCCCCATGAGCTGATTCGCACGCGGCAGCTTGAGAGCGTACATCTGA
AATTCAACCAGGAGTCCGGAGCCCTCATTCCTCTCTGCCTAAGGGGCAGGCTCCTGCATGGACGGCACTTTACATATAAAAGTATCACAG
GTGACATGGCCATCACGTTTGTCTCCACGGGAGTGGAAGGCGCCTTTGCCACTGAGGAGCATCCTTACGCGGCTCATGGACCCTGGTTAC
AAGCACTAAAGCAATCTTCAACCGAACTCCTCTTTGGAGGACACGAAACCACGGCCAGTGCAGCCACATCTCTGATCACTTACCTGGGGC
TCTACCCACATGTTCTCCAGAAAGTGCGAGAAGAGCTGAAGAGTAAGGGTTTACTTTGCAAGAGCAATCAAGACAACAAGTTGGACATGG
AAATTTTGGAACAACTTAAATACATCGGGTGTGTTATTAAGGAGACCCTTCGACTGAATCCCCCAGTTCCAGGAGGGTTTCGGGTTGCTC
TGAAGACTTTTGAATTAAATGGATACCAGATTCCCAAGGGCTGGAATGTTATCTACAGTATCTGTGATACTCATGATGTGGCAGAGATCT
TCACCAACAAGGAAGAATTTAATCCTGACCGATTCATGCTGCCTCACCCAGAGGATGCATCCAGGTTCAGCTTCATTCCATTTGGAGGAG
GCCTTAGGAGCTGTGTAGGCAAAGAATTTGCAAAAATTCTTCTCAAAATATTTACAGTGGAGCTGGCCAGGCATTGTGACTGGCAGCTTC
TAAATGGACCTCCTACAATGAAAACCAGTCCCACCGTGTATCCTGTGGACAATCTCCCTGCAAGATTCACCCATTTCCATGGGGAAATCT
GATGAGCTTGAATGTTCAAACCTGAGACTTATTGGAAGTGTACATATGAGTTTTTAAGGAGTGTTGTGTTGACTTTATATTTAATTTCTA
AATGTATATTATAATATTTATGTGTTTTGACTATACTACCACAATCTTTAAATATTAAAATAATGAATTTGTATCATTTCCAAATAAAGT
AAAATTTGAAGGTACTTTTCTGGTATTTTAAGATTCCTGTTGGGTAAAACTCACCAGTTTAGTATTTTCTTAGTGTATTTAACCAGATTT
TACAATGCCTACCTGGACTTATTTGTCATCTTTGCATCTGTTTTCTGTGAGAAGAAATCTTAGCTGTTTTTTATGTTAACAGTTATTAGA
AAATATATGTCTGTGTGTGTTATTCCAGACGTATCTCTGTAAATTCTTCTACAGTCACTTAGATTCCCTATTTGGAAAATTGATCCAAGT
TAATTTAATTTTTTTTTGGTTTGCTGTACTTTAGGGAAAGATGAACCTGAAAAGGTAACACTGAGAACTGTCACTCTAACCTCTCCAGCT

>87980_87980_2_SUFU-CYP26A1_SUFU_chr10_104377185_ENST00000369899_CYP26A1_chr10_94835583_ENST00000371531_length(amino acids)=664AA_BP=455
MARQCSPRRLPSPVPPVPALRTPMAELRPSGAPGPTAPPAPGPTAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGGPDP
LDYVSMYRNVGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSENTFCS
GDHVSWHSPLDNSESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHSAQQWNGQGILELLRTVPIAGGPWLITDMRRGETIFEI
DPHLQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDDEDSRSICIGTQPRRLSGKDTEQIRETLRRGLEINSKPVLPPINPQRQNGLAH
DRAPSRKDSLESDSSTAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAH
GPWLQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGG
FRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHC

--------------------------------------------------------------
>87980_87980_3_SUFU-CYP26A1_SUFU_chr10_104377185_ENST00000369899_CYP26A1_chr10_94835583_ENST00000394139_length(transcript)=2658nt_BP=1442nt
CGCCGTGCGCAGGCGCGGAGCTAGACCTCGCTGCAGCCCCCATCGCCTCGGGGAGTCTCACCCACCGAGTCCGCCCGCTGGCCCGTCAGT
GCTCTCCCCGTCGTTTGCCCTCTCCAGTTCCCCCAGTGCCTGCCCTACGCACCCCGATGGCGGAGCTGCGGCCTAGCGGCGCCCCCGGCC
CCACCGCGCCCCCGGCCCCTGGCCCGACTGCCCCCCCGGCCTTCGCTTCGCTCTTTCCCCCGGGACTGCACGCCATCTACGGAGAGTGCC
GCCGCCTTTACCCTGACCAGCCGAACCCGCTCCAGGTTACCGCTATCGTCAAGTACTGGTTGGGTGGCCCAGACCCCTTGGACTATGTTA
GCATGTACAGGAATGTGGGGAGCCCTTCTGCTAACATCCCCGAGCACTGGCACTACATCAGCTTCGGCCTGAGTGATCTCTATGGTGACA
ACAGAGTCCATGAGTTTACAGGAACAGATGGACCTAGTGGTTTTGGCTTTGAGTTGACCTTTCGTCTGAAGAGAGAAACTGGGGAGTCTG
CCCCACCAACATGGCCCGCAGAGTTAATGCAGGGCTTGGCACGATACGTGTTCCAGTCAGAGAACACCTTCTGCAGTGGGGACCATGTGT
CCTGGCACAGCCCTTTGGATAACAGTGAGTCAAGAATTCAGCACATGCTGCTGACAGAGGACCCACAGATGCAGCCCGTGCAGACACCCT
TTGGGGTAGTTACCTTCCTCCAGATCGTTGGTGTCTGCACTGAAGAGCTACACTCAGCCCAGCAGTGGAACGGGCAGGGCATCCTGGAGC
TGCTGCGGACAGTGCCTATTGCTGGCGGCCCCTGGCTGATAACTGACATGCGGAGGGGAGAGACCATATTTGAGATCGATCCACACCTGC
AAGAGAGAGTTGACAAAGGCATCGAGACAGATGGCTCCAACCTGAGTGGTGTCAGTGCCAAGTGTGCCTGGGATGACCTGAGCCGGCCCC
CCGAGGATGACGAGGACAGCCGGAGCATCTGCATCGGCACACAGCCCCGGCGACTCTCTGGCAAAGACACAGAGCAGATCCGGGAGACCC
TGAGGAGAGGACTCGAGATCAACAGCAAACCTGTCCTTCCACCAATCAACCCTCAGCGGCAGAATGGCCTCGCCCACGACCGGGCCCCGA
GCCGCAAAGACAGCCTGGAAAGTGACAGCTCCACGGCCATCATTCCCCATGAGCTGATTCGCACGCGGCAGCTTGAGAGCGTACATCTGA
AATTCAACCAGGAGTCCGGAGCCCTCATTCCTCTCTGCCTAAGGGGCAGGCTCCTGCATGGACGGCACTTTACATATAAAAGTATCACAG
GTGACATGGCCATCACGTTTGTCTCCACGGGAGTGGAAGGCGCCTTTGCCACTGAGGAGCATCCTTACGCGGCTCATGGACCCTGGTTAC
AAGCACTAAAGCAATCTTCAACCGAACTCCTCTTTGGAGGACACGAAACCACGGCCAGTGCAGCCACATCTCTGATCACTTACCTGGGGC
TCTACCCACATGTTCTCCAGAAAGTGCGAGAAGAGCTGAAGAGTAAGGGTTTACTTTGCAAGAGCAATCAAGACAACAAGTTGGACATGG
AAATTTTGGAACAACTTAAATACATCGGGTGTGTTATTAAGGAGACCCTTCGACTGAATCCCCCAGTTCCAGGAGGGTTTCGGGTTGCTC
TGAAGACTTTTGAATTAAATGGATACCAGATTCCCAAGGGCTGGAATGTTATCTACAGTATCTGTGATACTCATGATGTGGCAGAGATCT
TCACCAACAAGGAAGAATTTAATCCTGACCGATTCATGCTGCCTCACCCAGAGGATGCATCCAGGTTCAGCTTCATTCCATTTGGAGGAG
GCCTTAGGAGCTGTGTAGGCAAAGAATTTGCAAAAATTCTTCTCAAAATATTTACAGTGGAGCTGGCCAGGCATTGTGACTGGCAGCTTC
TAAATGGACCTCCTACAATGAAAACCAGTCCCACCGTGTATCCTGTGGACAATCTCCCTGCAAGATTCACCCATTTCCATGGGGAAATCT
GATGAGCTTGAATGTTCAAACCTGAGACTTATTGGAAGTGTACATATGAGTTTTTAAGGAGTGTTGTGTTGACTTTATATTTAATTTCTA
AATGTATATTATAATATTTATGTGTTTTGACTATACTACCACAATCTTTAAATATTAAAATAATGAATTTGTATCATTTCCAAATAAAGT
AAAATTTGAAGGTACTTTTCTGGTATTTTAAGATTCCTGTTGGGTAAAACTCACCAGTTTAGTATTTTCTTAGTGTATTTAACCAGATTT
TACAATGCCTACCTGGACTTATTTGTCATCTTTGCATCTGTTTTCTGTGAGAAGAAATCTTAGCTGTTTTTTATGTTAACAGTTATTAGA
AAATATATGTCTGTGTGTGTTATTCCAGACGTATCTCTGTAAATTCTTCTACAGTCACTTAGATTCCCTATTTGGAAAATTGATCCAAGT
TAATTTAATTTTTTTTTGGTTTGCTGTACTTTAGGGAAAGATGAACCTGAAAAGGTAACACTGAGAACTGTCACTCTAACCTCTCCAGCT

>87980_87980_3_SUFU-CYP26A1_SUFU_chr10_104377185_ENST00000369899_CYP26A1_chr10_94835583_ENST00000394139_length(amino acids)=664AA_BP=455
MARQCSPRRLPSPVPPVPALRTPMAELRPSGAPGPTAPPAPGPTAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGGPDP
LDYVSMYRNVGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSENTFCS
GDHVSWHSPLDNSESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHSAQQWNGQGILELLRTVPIAGGPWLITDMRRGETIFEI
DPHLQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDDEDSRSICIGTQPRRLSGKDTEQIRETLRRGLEINSKPVLPPINPQRQNGLAH
DRAPSRKDSLESDSSTAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAH
GPWLQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGG
FRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHC

--------------------------------------------------------------
>87980_87980_4_SUFU-CYP26A1_SUFU_chr10_104377185_ENST00000369902_CYP26A1_chr10_94835583_ENST00000224356_length(transcript)=2678nt_BP=1462nt
GACAGCCTGGGCGGACAGTGCGCCGTGCGCAGGCGCGGAGCTAGACCTCGCTGCAGCCCCCATCGCCTCGGGGAGTCTCACCCACCGAGT
CCGCCCGCTGGCCCGTCAGTGCTCTCCCCGTCGTTTGCCCTCTCCAGTTCCCCCAGTGCCTGCCCTACGCACCCCGATGGCGGAGCTGCG
GCCTAGCGGCGCCCCCGGCCCCACCGCGCCCCCGGCCCCTGGCCCGACTGCCCCCCCGGCCTTCGCTTCGCTCTTTCCCCCGGGACTGCA
CGCCATCTACGGAGAGTGCCGCCGCCTTTACCCTGACCAGCCGAACCCGCTCCAGGTTACCGCTATCGTCAAGTACTGGTTGGGTGGCCC
AGACCCCTTGGACTATGTTAGCATGTACAGGAATGTGGGGAGCCCTTCTGCTAACATCCCCGAGCACTGGCACTACATCAGCTTCGGCCT
GAGTGATCTCTATGGTGACAACAGAGTCCATGAGTTTACAGGAACAGATGGACCTAGTGGTTTTGGCTTTGAGTTGACCTTTCGTCTGAA
GAGAGAAACTGGGGAGTCTGCCCCACCAACATGGCCCGCAGAGTTAATGCAGGGCTTGGCACGATACGTGTTCCAGTCAGAGAACACCTT
CTGCAGTGGGGACCATGTGTCCTGGCACAGCCCTTTGGATAACAGTGAGTCAAGAATTCAGCACATGCTGCTGACAGAGGACCCACAGAT
GCAGCCCGTGCAGACACCCTTTGGGGTAGTTACCTTCCTCCAGATCGTTGGTGTCTGCACTGAAGAGCTACACTCAGCCCAGCAGTGGAA
CGGGCAGGGCATCCTGGAGCTGCTGCGGACAGTGCCTATTGCTGGCGGCCCCTGGCTGATAACTGACATGCGGAGGGGAGAGACCATATT
TGAGATCGATCCACACCTGCAAGAGAGAGTTGACAAAGGCATCGAGACAGATGGCTCCAACCTGAGTGGTGTCAGTGCCAAGTGTGCCTG
GGATGACCTGAGCCGGCCCCCCGAGGATGACGAGGACAGCCGGAGCATCTGCATCGGCACACAGCCCCGGCGACTCTCTGGCAAAGACAC
AGAGCAGATCCGGGAGACCCTGAGGAGAGGACTCGAGATCAACAGCAAACCTGTCCTTCCACCAATCAACCCTCAGCGGCAGAATGGCCT
CGCCCACGACCGGGCCCCGAGCCGCAAAGACAGCCTGGAAAGTGACAGCTCCACGGCCATCATTCCCCATGAGCTGATTCGCACGCGGCA
GCTTGAGAGCGTACATCTGAAATTCAACCAGGAGTCCGGAGCCCTCATTCCTCTCTGCCTAAGGGGCAGGCTCCTGCATGGACGGCACTT
TACATATAAAAGTATCACAGGTGACATGGCCATCACGTTTGTCTCCACGGGAGTGGAAGGCGCCTTTGCCACTGAGGAGCATCCTTACGC
GGCTCATGGACCCTGGTTACAAGCACTAAAGCAATCTTCAACCGAACTCCTCTTTGGAGGACACGAAACCACGGCCAGTGCAGCCACATC
TCTGATCACTTACCTGGGGCTCTACCCACATGTTCTCCAGAAAGTGCGAGAAGAGCTGAAGAGTAAGGGTTTACTTTGCAAGAGCAATCA
AGACAACAAGTTGGACATGGAAATTTTGGAACAACTTAAATACATCGGGTGTGTTATTAAGGAGACCCTTCGACTGAATCCCCCAGTTCC
AGGAGGGTTTCGGGTTGCTCTGAAGACTTTTGAATTAAATGGATACCAGATTCCCAAGGGCTGGAATGTTATCTACAGTATCTGTGATAC
TCATGATGTGGCAGAGATCTTCACCAACAAGGAAGAATTTAATCCTGACCGATTCATGCTGCCTCACCCAGAGGATGCATCCAGGTTCAG
CTTCATTCCATTTGGAGGAGGCCTTAGGAGCTGTGTAGGCAAAGAATTTGCAAAAATTCTTCTCAAAATATTTACAGTGGAGCTGGCCAG
GCATTGTGACTGGCAGCTTCTAAATGGACCTCCTACAATGAAAACCAGTCCCACCGTGTATCCTGTGGACAATCTCCCTGCAAGATTCAC
CCATTTCCATGGGGAAATCTGATGAGCTTGAATGTTCAAACCTGAGACTTATTGGAAGTGTACATATGAGTTTTTAAGGAGTGTTGTGTT
GACTTTATATTTAATTTCTAAATGTATATTATAATATTTATGTGTTTTGACTATACTACCACAATCTTTAAATATTAAAATAATGAATTT
GTATCATTTCCAAATAAAGTAAAATTTGAAGGTACTTTTCTGGTATTTTAAGATTCCTGTTGGGTAAAACTCACCAGTTTAGTATTTTCT
TAGTGTATTTAACCAGATTTTACAATGCCTACCTGGACTTATTTGTCATCTTTGCATCTGTTTTCTGTGAGAAGAAATCTTAGCTGTTTT
TTATGTTAACAGTTATTAGAAAATATATGTCTGTGTGTGTTATTCCAGACGTATCTCTGTAAATTCTTCTACAGTCACTTAGATTCCCTA
TTTGGAAAATTGATCCAAGTTAATTTAATTTTTTTTTGGTTTGCTGTACTTTAGGGAAAGATGAACCTGAAAAGGTAACACTGAGAACTG

>87980_87980_4_SUFU-CYP26A1_SUFU_chr10_104377185_ENST00000369902_CYP26A1_chr10_94835583_ENST00000224356_length(amino acids)=664AA_BP=455
MARQCSPRRLPSPVPPVPALRTPMAELRPSGAPGPTAPPAPGPTAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGGPDP
LDYVSMYRNVGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSENTFCS
GDHVSWHSPLDNSESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHSAQQWNGQGILELLRTVPIAGGPWLITDMRRGETIFEI
DPHLQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDDEDSRSICIGTQPRRLSGKDTEQIRETLRRGLEINSKPVLPPINPQRQNGLAH
DRAPSRKDSLESDSSTAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAH
GPWLQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGG
FRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHC

--------------------------------------------------------------
>87980_87980_5_SUFU-CYP26A1_SUFU_chr10_104377185_ENST00000369902_CYP26A1_chr10_94835583_ENST00000371531_length(transcript)=2672nt_BP=1462nt
GACAGCCTGGGCGGACAGTGCGCCGTGCGCAGGCGCGGAGCTAGACCTCGCTGCAGCCCCCATCGCCTCGGGGAGTCTCACCCACCGAGT
CCGCCCGCTGGCCCGTCAGTGCTCTCCCCGTCGTTTGCCCTCTCCAGTTCCCCCAGTGCCTGCCCTACGCACCCCGATGGCGGAGCTGCG
GCCTAGCGGCGCCCCCGGCCCCACCGCGCCCCCGGCCCCTGGCCCGACTGCCCCCCCGGCCTTCGCTTCGCTCTTTCCCCCGGGACTGCA
CGCCATCTACGGAGAGTGCCGCCGCCTTTACCCTGACCAGCCGAACCCGCTCCAGGTTACCGCTATCGTCAAGTACTGGTTGGGTGGCCC
AGACCCCTTGGACTATGTTAGCATGTACAGGAATGTGGGGAGCCCTTCTGCTAACATCCCCGAGCACTGGCACTACATCAGCTTCGGCCT
GAGTGATCTCTATGGTGACAACAGAGTCCATGAGTTTACAGGAACAGATGGACCTAGTGGTTTTGGCTTTGAGTTGACCTTTCGTCTGAA
GAGAGAAACTGGGGAGTCTGCCCCACCAACATGGCCCGCAGAGTTAATGCAGGGCTTGGCACGATACGTGTTCCAGTCAGAGAACACCTT
CTGCAGTGGGGACCATGTGTCCTGGCACAGCCCTTTGGATAACAGTGAGTCAAGAATTCAGCACATGCTGCTGACAGAGGACCCACAGAT
GCAGCCCGTGCAGACACCCTTTGGGGTAGTTACCTTCCTCCAGATCGTTGGTGTCTGCACTGAAGAGCTACACTCAGCCCAGCAGTGGAA
CGGGCAGGGCATCCTGGAGCTGCTGCGGACAGTGCCTATTGCTGGCGGCCCCTGGCTGATAACTGACATGCGGAGGGGAGAGACCATATT
TGAGATCGATCCACACCTGCAAGAGAGAGTTGACAAAGGCATCGAGACAGATGGCTCCAACCTGAGTGGTGTCAGTGCCAAGTGTGCCTG
GGATGACCTGAGCCGGCCCCCCGAGGATGACGAGGACAGCCGGAGCATCTGCATCGGCACACAGCCCCGGCGACTCTCTGGCAAAGACAC
AGAGCAGATCCGGGAGACCCTGAGGAGAGGACTCGAGATCAACAGCAAACCTGTCCTTCCACCAATCAACCCTCAGCGGCAGAATGGCCT
CGCCCACGACCGGGCCCCGAGCCGCAAAGACAGCCTGGAAAGTGACAGCTCCACGGCCATCATTCCCCATGAGCTGATTCGCACGCGGCA
GCTTGAGAGCGTACATCTGAAATTCAACCAGGAGTCCGGAGCCCTCATTCCTCTCTGCCTAAGGGGCAGGCTCCTGCATGGACGGCACTT
TACATATAAAAGTATCACAGGTGACATGGCCATCACGTTTGTCTCCACGGGAGTGGAAGGCGCCTTTGCCACTGAGGAGCATCCTTACGC
GGCTCATGGACCCTGGTTACAAGCACTAAAGCAATCTTCAACCGAACTCCTCTTTGGAGGACACGAAACCACGGCCAGTGCAGCCACATC
TCTGATCACTTACCTGGGGCTCTACCCACATGTTCTCCAGAAAGTGCGAGAAGAGCTGAAGAGTAAGGGTTTACTTTGCAAGAGCAATCA
AGACAACAAGTTGGACATGGAAATTTTGGAACAACTTAAATACATCGGGTGTGTTATTAAGGAGACCCTTCGACTGAATCCCCCAGTTCC
AGGAGGGTTTCGGGTTGCTCTGAAGACTTTTGAATTAAATGGATACCAGATTCCCAAGGGCTGGAATGTTATCTACAGTATCTGTGATAC
TCATGATGTGGCAGAGATCTTCACCAACAAGGAAGAATTTAATCCTGACCGATTCATGCTGCCTCACCCAGAGGATGCATCCAGGTTCAG
CTTCATTCCATTTGGAGGAGGCCTTAGGAGCTGTGTAGGCAAAGAATTTGCAAAAATTCTTCTCAAAATATTTACAGTGGAGCTGGCCAG
GCATTGTGACTGGCAGCTTCTAAATGGACCTCCTACAATGAAAACCAGTCCCACCGTGTATCCTGTGGACAATCTCCCTGCAAGATTCAC
CCATTTCCATGGGGAAATCTGATGAGCTTGAATGTTCAAACCTGAGACTTATTGGAAGTGTACATATGAGTTTTTAAGGAGTGTTGTGTT
GACTTTATATTTAATTTCTAAATGTATATTATAATATTTATGTGTTTTGACTATACTACCACAATCTTTAAATATTAAAATAATGAATTT
GTATCATTTCCAAATAAAGTAAAATTTGAAGGTACTTTTCTGGTATTTTAAGATTCCTGTTGGGTAAAACTCACCAGTTTAGTATTTTCT
TAGTGTATTTAACCAGATTTTACAATGCCTACCTGGACTTATTTGTCATCTTTGCATCTGTTTTCTGTGAGAAGAAATCTTAGCTGTTTT
TTATGTTAACAGTTATTAGAAAATATATGTCTGTGTGTGTTATTCCAGACGTATCTCTGTAAATTCTTCTACAGTCACTTAGATTCCCTA
TTTGGAAAATTGATCCAAGTTAATTTAATTTTTTTTTGGTTTGCTGTACTTTAGGGAAAGATGAACCTGAAAAGGTAACACTGAGAACTG

>87980_87980_5_SUFU-CYP26A1_SUFU_chr10_104377185_ENST00000369902_CYP26A1_chr10_94835583_ENST00000371531_length(amino acids)=664AA_BP=455
MARQCSPRRLPSPVPPVPALRTPMAELRPSGAPGPTAPPAPGPTAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGGPDP
LDYVSMYRNVGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSENTFCS
GDHVSWHSPLDNSESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHSAQQWNGQGILELLRTVPIAGGPWLITDMRRGETIFEI
DPHLQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDDEDSRSICIGTQPRRLSGKDTEQIRETLRRGLEINSKPVLPPINPQRQNGLAH
DRAPSRKDSLESDSSTAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAH
GPWLQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGG
FRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHC

--------------------------------------------------------------
>87980_87980_6_SUFU-CYP26A1_SUFU_chr10_104377185_ENST00000369902_CYP26A1_chr10_94835583_ENST00000394139_length(transcript)=2678nt_BP=1462nt
GACAGCCTGGGCGGACAGTGCGCCGTGCGCAGGCGCGGAGCTAGACCTCGCTGCAGCCCCCATCGCCTCGGGGAGTCTCACCCACCGAGT
CCGCCCGCTGGCCCGTCAGTGCTCTCCCCGTCGTTTGCCCTCTCCAGTTCCCCCAGTGCCTGCCCTACGCACCCCGATGGCGGAGCTGCG
GCCTAGCGGCGCCCCCGGCCCCACCGCGCCCCCGGCCCCTGGCCCGACTGCCCCCCCGGCCTTCGCTTCGCTCTTTCCCCCGGGACTGCA
CGCCATCTACGGAGAGTGCCGCCGCCTTTACCCTGACCAGCCGAACCCGCTCCAGGTTACCGCTATCGTCAAGTACTGGTTGGGTGGCCC
AGACCCCTTGGACTATGTTAGCATGTACAGGAATGTGGGGAGCCCTTCTGCTAACATCCCCGAGCACTGGCACTACATCAGCTTCGGCCT
GAGTGATCTCTATGGTGACAACAGAGTCCATGAGTTTACAGGAACAGATGGACCTAGTGGTTTTGGCTTTGAGTTGACCTTTCGTCTGAA
GAGAGAAACTGGGGAGTCTGCCCCACCAACATGGCCCGCAGAGTTAATGCAGGGCTTGGCACGATACGTGTTCCAGTCAGAGAACACCTT
CTGCAGTGGGGACCATGTGTCCTGGCACAGCCCTTTGGATAACAGTGAGTCAAGAATTCAGCACATGCTGCTGACAGAGGACCCACAGAT
GCAGCCCGTGCAGACACCCTTTGGGGTAGTTACCTTCCTCCAGATCGTTGGTGTCTGCACTGAAGAGCTACACTCAGCCCAGCAGTGGAA
CGGGCAGGGCATCCTGGAGCTGCTGCGGACAGTGCCTATTGCTGGCGGCCCCTGGCTGATAACTGACATGCGGAGGGGAGAGACCATATT
TGAGATCGATCCACACCTGCAAGAGAGAGTTGACAAAGGCATCGAGACAGATGGCTCCAACCTGAGTGGTGTCAGTGCCAAGTGTGCCTG
GGATGACCTGAGCCGGCCCCCCGAGGATGACGAGGACAGCCGGAGCATCTGCATCGGCACACAGCCCCGGCGACTCTCTGGCAAAGACAC
AGAGCAGATCCGGGAGACCCTGAGGAGAGGACTCGAGATCAACAGCAAACCTGTCCTTCCACCAATCAACCCTCAGCGGCAGAATGGCCT
CGCCCACGACCGGGCCCCGAGCCGCAAAGACAGCCTGGAAAGTGACAGCTCCACGGCCATCATTCCCCATGAGCTGATTCGCACGCGGCA
GCTTGAGAGCGTACATCTGAAATTCAACCAGGAGTCCGGAGCCCTCATTCCTCTCTGCCTAAGGGGCAGGCTCCTGCATGGACGGCACTT
TACATATAAAAGTATCACAGGTGACATGGCCATCACGTTTGTCTCCACGGGAGTGGAAGGCGCCTTTGCCACTGAGGAGCATCCTTACGC
GGCTCATGGACCCTGGTTACAAGCACTAAAGCAATCTTCAACCGAACTCCTCTTTGGAGGACACGAAACCACGGCCAGTGCAGCCACATC
TCTGATCACTTACCTGGGGCTCTACCCACATGTTCTCCAGAAAGTGCGAGAAGAGCTGAAGAGTAAGGGTTTACTTTGCAAGAGCAATCA
AGACAACAAGTTGGACATGGAAATTTTGGAACAACTTAAATACATCGGGTGTGTTATTAAGGAGACCCTTCGACTGAATCCCCCAGTTCC
AGGAGGGTTTCGGGTTGCTCTGAAGACTTTTGAATTAAATGGATACCAGATTCCCAAGGGCTGGAATGTTATCTACAGTATCTGTGATAC
TCATGATGTGGCAGAGATCTTCACCAACAAGGAAGAATTTAATCCTGACCGATTCATGCTGCCTCACCCAGAGGATGCATCCAGGTTCAG
CTTCATTCCATTTGGAGGAGGCCTTAGGAGCTGTGTAGGCAAAGAATTTGCAAAAATTCTTCTCAAAATATTTACAGTGGAGCTGGCCAG
GCATTGTGACTGGCAGCTTCTAAATGGACCTCCTACAATGAAAACCAGTCCCACCGTGTATCCTGTGGACAATCTCCCTGCAAGATTCAC
CCATTTCCATGGGGAAATCTGATGAGCTTGAATGTTCAAACCTGAGACTTATTGGAAGTGTACATATGAGTTTTTAAGGAGTGTTGTGTT
GACTTTATATTTAATTTCTAAATGTATATTATAATATTTATGTGTTTTGACTATACTACCACAATCTTTAAATATTAAAATAATGAATTT
GTATCATTTCCAAATAAAGTAAAATTTGAAGGTACTTTTCTGGTATTTTAAGATTCCTGTTGGGTAAAACTCACCAGTTTAGTATTTTCT
TAGTGTATTTAACCAGATTTTACAATGCCTACCTGGACTTATTTGTCATCTTTGCATCTGTTTTCTGTGAGAAGAAATCTTAGCTGTTTT
TTATGTTAACAGTTATTAGAAAATATATGTCTGTGTGTGTTATTCCAGACGTATCTCTGTAAATTCTTCTACAGTCACTTAGATTCCCTA
TTTGGAAAATTGATCCAAGTTAATTTAATTTTTTTTTGGTTTGCTGTACTTTAGGGAAAGATGAACCTGAAAAGGTAACACTGAGAACTG

>87980_87980_6_SUFU-CYP26A1_SUFU_chr10_104377185_ENST00000369902_CYP26A1_chr10_94835583_ENST00000394139_length(amino acids)=664AA_BP=455
MARQCSPRRLPSPVPPVPALRTPMAELRPSGAPGPTAPPAPGPTAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGGPDP
LDYVSMYRNVGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSENTFCS
GDHVSWHSPLDNSESRIQHMLLTEDPQMQPVQTPFGVVTFLQIVGVCTEELHSAQQWNGQGILELLRTVPIAGGPWLITDMRRGETIFEI
DPHLQERVDKGIETDGSNLSGVSAKCAWDDLSRPPEDDEDSRSICIGTQPRRLSGKDTEQIRETLRRGLEINSKPVLPPINPQRQNGLAH
DRAPSRKDSLESDSSTAIIPHELIRTRQLESVHLKFNQESGALIPLCLRGRLLHGRHFTYKSITGDMAITFVSTGVEGAFATEEHPYAAH
GPWLQALKQSSTELLFGGHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGG
FRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHC

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SUFU-CYP26A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SUFU-CYP26A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SUFU-CYP26A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource