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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SUFU-GBF1 (FusionGDB2 ID:87983)

Fusion Gene Summary for SUFU-GBF1

check button Fusion gene summary
Fusion gene informationFusion gene name: SUFU-GBF1
Fusion gene ID: 87983
HgeneTgene
Gene symbol

SUFU

GBF1

Gene ID

51684

80142

Gene nameSUFU negative regulator of hedgehog signalingprostaglandin E synthase 2
SynonymsJBTS32|PRO1280|SUFUH|SUFUXLC9orf15|GBF-1|GBF1|PGES2|mPGES-2
Cytomap

10q24.32

9q34.11

Type of geneprotein-codingprotein-coding
Descriptionsuppressor of fused homologprostaglandin E synthase 2GATE-binding factor 1gamma-interferon-activated transcriptional element-binding factor 1mPGE synthase-2membrane-associated prostaglandin E synthase 2microsomal prostaglandin E synthase-2prostaglandin-H(2) E-isomerase
Modification date2020031320200313
UniProtAcc.

Q92538

Ensembl transtripts involved in fusion geneENST00000369899, ENST00000369902, 
ENST00000423559, ENST00000471000, 
ENST00000476019, ENST00000369983, 
Fusion gene scores* DoF score10 X 7 X 6=42012 X 12 X 4=576
# samples 1312
** MAII scorelog2(13/420*10)=-1.69187770463767
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/576*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SUFU [Title/Abstract] AND GBF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSUFU(104309863)-GBF1(104111013), # samples:8
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSUFU

GO:0000122

negative regulation of transcription by RNA polymerase II

10564661


check buttonFusion gene breakpoints across SUFU (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GBF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A15E-01ASUFUchr10

104309863

-GBF1chr10

104111013

+
ChimerDB4BRCATCGA-E2-A15E-01ASUFUchr10

104309863

+GBF1chr10

104111013

+
ChimerDB4BRCATCGA-E2-A15E-06ASUFUchr10

104309863

-GBF1chr10

104111013

+
ChimerDB4BRCATCGA-E2-A15E-06ASUFUchr10

104309863

+GBF1chr10

104111013

+
ChimerDB4UCECTCGA-B5-A3S1-01ASUFUchr10

104309863

-GBF1chr10

104111013

+
ChimerDB4UCECTCGA-B5-A3S1-01ASUFUchr10

104309863

+GBF1chr10

104111013

+


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Fusion Gene ORF analysis for SUFU-GBF1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000369899ENST00000476019SUFUchr10

104309863

+GBF1chr10

104111013

+
5CDS-intronENST00000369902ENST00000476019SUFUchr10

104309863

+GBF1chr10

104111013

+
5CDS-intronENST00000423559ENST00000476019SUFUchr10

104309863

+GBF1chr10

104111013

+
In-frameENST00000369899ENST00000369983SUFUchr10

104309863

+GBF1chr10

104111013

+
In-frameENST00000369902ENST00000369983SUFUchr10

104309863

+GBF1chr10

104111013

+
In-frameENST00000423559ENST00000369983SUFUchr10

104309863

+GBF1chr10

104111013

+
intron-3CDSENST00000471000ENST00000369983SUFUchr10

104309863

+GBF1chr10

104111013

+
intron-intronENST00000471000ENST00000476019SUFUchr10

104309863

+GBF1chr10

104111013

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369902SUFUchr10104309863+ENST00000369983GBF1chr10104111013+64686209759041935
ENST00000369899SUFUchr10104309863+ENST00000369983GBF1chr10104111013+64486007758841935
ENST00000423559SUFUchr10104309863+ENST00000369983GBF1chr10104111013+6376528558121935

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369902ENST00000369983SUFUchr10104309863+GBF1chr10104111013+0.0028639620.997136
ENST00000369899ENST00000369983SUFUchr10104309863+GBF1chr10104111013+0.0028588120.99714124
ENST00000423559ENST00000369983SUFUchr10104309863+GBF1chr10104111013+0.0025993920.99740064

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Fusion Genomic Features for SUFU-GBF1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SUFUchr10104309863+GBF1chr10104111012+1.32E-121
SUFUchr10104309863+GBF1chr10104111012+1.32E-121
SUFUchr10104309863+GBF1chr10104111012+1.32E-121
SUFUchr10104309863+GBF1chr10104111012+1.32E-121
SUFUchr10104309863+GBF1chr10104111012+1.32E-121
SUFUchr10104309863+GBF1chr10104111012+1.32E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SUFU-GBF1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:104309863/chr10:104111013)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.GBF1

Q92538

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), and the endoplasmic reticulum-Golgi intermediate (ERGIC) and cis-Golgi compartments which implicates ARF1 activation. Involved in COPI vesicle-dependent retrograde transport from the ERGIC and cis-Golgi compartments to the endoplasmic reticulum (ER) (PubMed:16926190, PubMed:17956946, PubMed:18003980, PubMed:12047556, PubMed:12808027, PubMed:19039328, PubMed:24213530). Involved in the trans-Golgi network recruitment of GGA1, GGA2, GGA3, BIG1, BIG2, and the AP-1 adapter protein complex related to chlathrin-dependent transport; the function requires its GEF activity (probably at least in part on ARF4 and ARF5) (PubMed:23386609). Has GEF activity towards ARF1 (PubMed:15616190). Has in vitro GEF activity towards ARF5 (By similarity). Involved in the processing of PSAP (PubMed:17666033). Required for the assembly of the Golgi apparatus (PubMed:12808027, PubMed:18003980). The AMPK-phosphorylated form is involved in Golgi disassembly during mitotis and under stress conditions (PubMed:18063581, PubMed:23418352). May be involved in the COPI vesicle-dependent recruitment of PNPLA2 to lipid droplets; however, this function is under debate (PubMed:19461073, PubMed:22185782). In neutrophils, involved in G protein-coupled receptor (GPCR)-mediated chemotaxis und superoxide production. Proposed to be recruited by phosphatidylinositol-phosphates generated upon GPCR stimulation to the leading edge where it recruits and activates ARF1, and is involved in recruitment of GIT2 and the NADPH oxidase complex (PubMed:22573891). Plays a role in maintaining mitochondrial morphology (PubMed:25190516). {ECO:0000250|UniProtKB:Q9R1D7, ECO:0000269|PubMed:12047556, ECO:0000269|PubMed:12808027, ECO:0000269|PubMed:15616190, ECO:0000269|PubMed:16926190, ECO:0000269|PubMed:17666033, ECO:0000269|PubMed:17956946, ECO:0000269|PubMed:18003980, ECO:0000269|PubMed:18063581, ECO:0000269|PubMed:19461073, ECO:0000269|PubMed:22185782, ECO:0000269|PubMed:22573891, ECO:0000269|PubMed:23386609, ECO:0000269|PubMed:23418352, ECO:0000269|PubMed:24213530, ECO:0000269|PubMed:25190516, ECO:0000305|PubMed:19039328, ECO:0000305|PubMed:22573891}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGBF1chr10:104309863chr10:104111013ENST000003699833401751_1854981860.0Compositional biasNote=Pro-rich
TgeneGBF1chr10:104309863chr10:104111013ENST00000369983340692_882981860.0DomainSEC7
TgeneGBF1chr10:104309863chr10:104111013ENST00000369983340886_1370981860.0RegionPhosphatidylinositol-phosphate binding%3B required for translocation to the leading edge and for ARF1 activation upon GPCR signaling

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSUFUchr10:104309863chr10:104111013ENST00000369899+311279_360151434.0RegionIntrinsically disordered
HgeneSUFUchr10:104309863chr10:104111013ENST00000369902+312279_360151485.0RegionIntrinsically disordered
HgeneSUFUchr10:104309863chr10:104111013ENST00000423559+310279_360151482.0RegionIntrinsically disordered


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Fusion Gene Sequence for SUFU-GBF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>87983_87983_1_SUFU-GBF1_SUFU_chr10_104309863_ENST00000369899_GBF1_chr10_104111013_ENST00000369983_length(transcript)=6448nt_BP=600nt
CGCCGTGCGCAGGCGCGGAGCTAGACCTCGCTGCAGCCCCCATCGCCTCGGGGAGTCTCACCCACCGAGTCCGCCCGCTGGCCCGTCAGT
GCTCTCCCCGTCGTTTGCCCTCTCCAGTTCCCCCAGTGCCTGCCCTACGCACCCCGATGGCGGAGCTGCGGCCTAGCGGCGCCCCCGGCC
CCACCGCGCCCCCGGCCCCTGGCCCGACTGCCCCCCCGGCCTTCGCTTCGCTCTTTCCCCCGGGACTGCACGCCATCTACGGAGAGTGCC
GCCGCCTTTACCCTGACCAGCCGAACCCGCTCCAGGTTACCGCTATCGTCAAGTACTGGTTGGGTGGCCCAGACCCCTTGGACTATGTTA
GCATGTACAGGAATGTGGGGAGCCCTTCTGCTAACATCCCCGAGCACTGGCACTACATCAGCTTCGGCCTGAGTGATCTCTATGGTGACA
ACAGAGTCCATGAGTTTACAGGAACAGATGGACCTAGTGGTTTTGGCTTTGAGTTGACCTTTCGTCTGAAGAGAGAAACTGGGGAGTCTG
CCCCACCAACATGGCCCGCAGAGTTAATGCAGGGCTTGGCACGATACGTGTTCCAGTCAGATCCCACCCATGAGGGCACAGCAGAGGGCA
TGGAGAACATGGCAGATGCTGTCACCCATGCTCGTTTTGTGGGCACGGATCCTGCCAGTGATGAAGTTGTCCTGATGAAAATCCTTCAGG
TTCTACGGACTCTGCTGCTAACCCCAGTGGGTGCCCACCTAACCAATGAATCTGTGTGTGAGATTATGCAGTCTTGCTTCCGGATCTGCT
TTGAAATGAGGCTCAGTGAGTTATTGAGAAAATCCGCAGAGCACACTCTCGTAGACATGGTGCAGCTGCTCTTCACAAGGTTACCTCAGT
TTAAAGAAGAACCCAAGAACTATGTGGGGACCAACATGAAGAAGCTGAAAATGAGAGCCGGAGGCATGAGTGATTCATCCAAATGGAAGA
AACAGAAGAGATCCCCTCGGCCCCCACGCCATATGACCAAAGTCACACCAGGTTCAGAGCTGCCCACTCCCAATGGAACCACCTTATCAT
CTAACCTCACTGGTGGCATGCCCTTCATTGATGTGCCCACTCCCATCTCCTCTGCAAGTTCAGAAGCTGCCTCAGCAGTGGTCAGTCCCT
CTACAGACAGTGGCCTGGAATTCTCCTCCCAAACCACTTCCAAGGAAGACCTTACTGATCTAGAGCAACCTGGCTCTCCAGGGTACAGCA
CAGCTACAGAGCCTGGAAGCAGTGAGCTAGGTGTTCCCGAGCAGCCTGACCTCCAGGAAGGGACCCATGTGGAAAAGTCCCAGTCAGCAT
CTGTGGAGTCCATCCCTGAAGTGTTAGAGGAGTGCACGTCCCCTGCCGACCACTCTGACTCTGCCTCTGTCCATGACATGGATTACGTCA
ATCCCCGGGGCGTGCGCTTTACACAGTCCTCCCAGAAAGAAGGCACAGCTTTGGTCCCCTATGGTCTTCCCTGCATCCGCGAGCTCTTCC
GCTTCCTCATCTCCCTCACCAATCCACACGACCGCCATAACTCAGAGGTTATGATTCACATGGGACTGCATTTGCTGACAGTGGCCCTTG
AGTCAGCCCCTGTAGCCCAGTGCCAGACCCTCTTGGGCCTCATCAAGGATGAGATGTGCCGTCACTTATTCCAGCTACTCAGCATAGAGC
GACTAAACCTTTATGCTGCTTCCCTGCGAGTATGCTTCCTACTGTTTGAGAGCATGCGAGAGCACCTCAAGTTCCAAATGGAGATGTACA
TCAAAAAGCTTATGGAGATCATCACTGTGGAGAACCCCAAGATGCCTTATGAGATGAAGGAGATGGCACTGGAGGCCATTGTGCAGCTCT
GGCGCATCCCCAGCTTTGTCACAGAGCTCTACATCAACTATGATTGTGACTACTACTGTTCCAACCTCTTTGAGGAACTCACAAAGCTGC
TGTCCAAGAATGCCTTCCCTGTGTCTGGTCAACTCTATACAACACACCTACTATCTCTTGATGCCCTATTGACAGTGATTGACAGCACCG
AGGCCCACTGCCAGGCTAAAGTCCTCAACAGCCTCACCCAGCAAGAGAAGAAGGAGACAGCCAGACCAAGCTGTGAGATAGTAGATGGCA
CCCGAGAAGCTAGCAATACTGAGAGAACTGCCAGCGATGGGAAAGCTGTAGGCATGGCCTCAGACATCCCAGGCCTGCATCTGCCAGGTG
GAGGGCGGCTGCCACCAGAACATGGGAAATCAGGATGCAGTGATCTGGAGGAAGCTGTTGACTCTGGGGCTGACAAAAAGTTTGCCCGGA
AGCCACCCCGATTTTCCTGTCTCCTGCCAGATCCACGGGAACTAATTGAAATTAAAAACAAAAAGAAGCTGCTAATCACTGGCACAGAGC
AGTTCAATCAGAAACCAAAGAAGGGGATTCAGTTTCTGCAAGAGAAAGGCCTCCTCACCATCCCAATGGACAACACAGAGGTTGCTCAGT
GGCTCCGAGAGAACCCTCGGCTGGACAAGAAGATGATTGGAGAGTTTGTGAGTGACCGCAAAAACATTGACCTGTTGGAGAGCTTTGTGA
GCACCTTCAGTTTTCAGGGTCTGCGACTGGACGAAGCCCTCCGCCTCTACCTGGAAGCCTTCCGTTTGCCTGGGGAAGCACCAGTCATCC
AGAGGTTGCTGGAGGCATTCACAGAGCGTTGGATGAATTGTAATGGCTCCCCATTTGCCAATAGCGATGCCTGCTTTTCCCTGGCCTATG
CTGTCATCATGCTTAATACTGACCAGCACAACCACAATGTTCGTAAACAGAATGCACCCATGACCCTGGAGGAGTTTCGCAAAAATCTGA
AAGGTGTGAATGGAGGCAAGGACTTTGAGCAAGACATCCTGGAGGACATGTACCATGCCATCAAGAATGAGGAAATTGTAATGCCTGAGG
AGCAGACAGGCTTGGTTCGGGAGAACTATGTGTGGAATGTGCTGCTTCATCGAGGTGCCACCCCTGAGGGCATATTCCTGCGTGTGCCTA
CTGCCAGCTATGATCTTGACCTCTTCACCATGACCTGGGGCCCCACTATTGCTGCTCTCTCTTATGTCTTTGACAAAAGCCTTGAGGAGA
CAATCATCCAGAAAGCCATCTCAGGCTTCAGGAAGTGCGCCATGATCTCCGCCCACTATGGCCTCAGCGATGTGTTTGACAATCTCATCA
TCTCTCTATGCAAATTCACAGCTCTCAGCAGTGAGTCTATTGAGAACCTGCCCAGTGTATTTGGAAGCAACCCTAAAGCCCATATTGCAG
CCAAGACAGTATTCCATTTGGCCCATCGTCATGGTGACATCCTGCGGGAGGGCTGGAAGAATATCATGGAGGCCATGCTGCAGCTCTTCC
GAGCCCAACTACTGCCCAAGGCTATGATAGAGGTAGAAGATTTCGTGGATCCCAATGGCAAGATCTCTCTACAGCGGGAAGAGACACCAT
CAAACCGAGGAGAGTCAACAGTGCTGAGCTTTGTGAGCTGGCTAACACTGAGTGGTCCTGAGCAGTCTAGTGTTCGGGGCCCATCCACTG
AAAACCAAGAGGCCAAGAGAGTGGCCTTAGAGTGTATAAAGCAATGTGACCCAGAAAAAATGATCACAGAAAGCAAGTTCCTCCAGCTGG
AGTCACTACAGGAGCTCATGAAGGCTCTGGTCTCAGTGACACCAGATGAAGAGACATATGATGAGGAAGATGCTGCTTTCTGCCTAGAGA
TGCTGCTAAGGATTGTGTTGGAGAACAGGGATCGTGTGGGCTGTGTGTGGCAGACTGTTCGAGACCATCTATACCACCTCTGTGTTCAGG
CACAAGATTTCTGCTTCCTTGTGGAGCGGGCAGTGGTGGGGTTGCTACGCCTGGCCATTCGGCTTCTCCGGAGAGAAGAGATCAGTGCTC
AGGTGCTGCTCTCCCTGCGCATTTTGCTACTGATGAAGCCCAGTGTGCTATCCCGAGTCAGCCACCAGGTTGCGTATGGGCTCCATGAAC
TCCTGAAGACCAATGCAGCCAACATCCACTCAGGTGATGACTGGGCCACACTCTTCACACTGCTGGAGTGCATCGGCTCAGGTGTGAAGC
CTCCAGCTGCTCTGCAGGCCACAGCCAGGGCAGATGCACCTGATGCCGGGGCCCAGTCAGATAGTGAGCTCCCATCCTACCATCAGAATG
ACGTGAGCCTGGATCGAGGGTACACTTCCGACTCAGAGGTCTACACTGACCATGGCAGGCCGGGCAAGATACACCGATCAGCCACAGATG
CCGATGTGGTCAACAGTGGTTGGTTAGTGGTTGGGAAGGATGACGTTGATAACTCCAAGCCAGGGCCCAGCCGCCCAGGCCCTTCACCCC
TGATCAATCAATACAGCCTAACAGTGGGACTGGATTTGGGGCCACACGACACTAAGTCTCTGCTTAAGTGTGTGGAATCGCTGTCCTTCA
TTGTGCGTGATGCTGCCCACATCACACCTGACAACTTTGAGCTCTGCGTCAAGACTCTCCGGATCTTTGTGGAGGCCAGTCTGAATGGCG
GATGCAAGTCCCAGGAGAAACGTGGCAAGAGTCACAAATATGACAGCAAAGGGAACCGCTTCAAGAAGAAATCCAAAGAGGGATCAATGC
TTCGCCGGCCTCGAACCTCCAGCCAACATGCCTCTCGGGGCGGGCAGAGTGATGATGATGAGGACGAAGGCGTGCCTGCCAGCTACCATA
CGGTGTCTTTACAGGTCAGTCAGGACTTGCTAGACCTGATGCACACCCTGCACACGCGGGCAGCCTCTATCTACAGCTCATGGGCGGAGG
AGCAACGCCACCTGGAGACAGGTGGCCAGAAGATTGAAGCTGATTCTCGCACCCTCTGGGCCCACTGCTGGTGCCCTTTACTGCAGGGTA
TTGCCTGCCTGTGCTGCGATGCCCGGCGCCAGGTACGGATGCAGGCACTGACCTATCTGCAGCGAGCACTACTTGTACATGATCTGCAAA
AGCTAGATGCCCTGGAATGGGAGTCCTGTTTTAACAAGGTGCTGTTTCCTCTACTTACCAAGCTCTTGGAGAACATCAGCCCTGCAGATG
TGGGTGGGATGGAGGAGACCCGGATGAGGGCTTCCACATTGCTCTCTAAGGTCTTCCTGCAGCACCTGTCTCCACTGCTGTCACTCTCTA
CCTTTGCGGCCCTCTGGCTCACCATCTTGGACTTCATGGACAAGTACATGCACGCAGGCTCCAGCGACTTACTGTCAGAGGCGATCCCTG
AGTCTCTGAAGAACATGCTTCTGGTGATGGACACAGCGGAGATTTTCCACAGTGCAGATGCACGGGGAGGCGGCCCCTCGGCCCTCTGGG
AGATCACCTGGGAACGCATTGACTGTTTTCTCCCTCACCTACGAGATGAACTCTTCAAGCAGACCGTCATCCAGGACCCCATGCCCATGG
AGCCTCAAGGCCAAAAGCCTCTCGCCTCAGCCCACCTGACTTCCGCTGCTGGCGACACTAGGACACCTGGCCATCCACCGCCCCCAGAGA
TTCCATCTGAGCTGGGGGCCTGTGACTTTGAGAAGCCCGAGAGCCCCCGAGCCGCCAGCAGCAGCTCCCCAGGATCACCAGTGGCCTCAA
GCCCCAGCAGGCTGAGCCCCACCCCCGACGGGCCTCCACCCTTGGCTCAGCCCCCACTGATCCTGCAGCCCTTGGCCTCCCCACTGCAGG
TGGGCGTGCCACCTATGACTCTGCCCATCATCCTCAACCCTGCGCTCATCGAGGCCACCTCACCAGTGCCCCTCCTGGCCACACCCCGCC
CCACAGATCCCATACCCACCTCTGAGGTCAACTAAGGCAGGTCACTCAGAGATCAGGACCAGTGCTTCCCACCAGGCTTTCCTTGACCCC
ACTTCTGGCTGTCCTGCGGGCCACAAGCTCTTCAGGCCAAGTCAGAGCTGCTGTTGCTGCCACTTGGATGGGGACCTGAAAAAGAGAATG
TTGATAGCCCCAGCTAAGACCCCCAATCAGCTGTGGGACCTTTTTCCTCCTCTGCGCTCCATTCCTGGGGGTTCAGCCTGAGAGTGAACT
CAGCTGTCATCTGCAGCCTCTGCCTCCAGCCCGGCAGCTCTGGGGAGGCATCCGTGTGCCGGCCCTGCAGTGCCTGCCCACGGTCAGGCA
TTGAAAACTAAGCCCAACCACTCTGCACTTTGTTTCCCACTCCCATTAGCCCTGGGCCACCTCCTCCAGTTCTTCCTCTTTTACTAATTA
GTTGGTCAGTTTGGAGAGTTGACTGGCACCATGGAGGGTAGGCAGGTGGGGGCTGGGTGGGGGACTGCCCACAGGAGCATGTACATATGG

>87983_87983_1_SUFU-GBF1_SUFU_chr10_104309863_ENST00000369899_GBF1_chr10_104111013_ENST00000369983_length(amino acids)=1935AA_BP=174
MARQCSPRRLPSPVPPVPALRTPMAELRPSGAPGPTAPPAPGPTAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGGPDP
LDYVSMYRNVGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSDPTHEG
TAEGMENMADAVTHARFVGTDPASDEVVLMKILQVLRTLLLTPVGAHLTNESVCEIMQSCFRICFEMRLSELLRKSAEHTLVDMVQLLFT
RLPQFKEEPKNYVGTNMKKLKMRAGGMSDSSKWKKQKRSPRPPRHMTKVTPGSELPTPNGTTLSSNLTGGMPFIDVPTPISSASSEAASA
VVSPSTDSGLEFSSQTTSKEDLTDLEQPGSPGYSTATEPGSSELGVPEQPDLQEGTHVEKSQSASVESIPEVLEECTSPADHSDSASVHD
MDYVNPRGVRFTQSSQKEGTALVPYGLPCIRELFRFLISLTNPHDRHNSEVMIHMGLHLLTVALESAPVAQCQTLLGLIKDEMCRHLFQL
LSIERLNLYAASLRVCFLLFESMREHLKFQMEMYIKKLMEIITVENPKMPYEMKEMALEAIVQLWRIPSFVTELYINYDCDYYCSNLFEE
LTKLLSKNAFPVSGQLYTTHLLSLDALLTVIDSTEAHCQAKVLNSLTQQEKKETARPSCEIVDGTREASNTERTASDGKAVGMASDIPGL
HLPGGGRLPPEHGKSGCSDLEEAVDSGADKKFARKPPRFSCLLPDPRELIEIKNKKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNT
EVAQWLRENPRLDKKMIGEFVSDRKNIDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIQRLLEAFTERWMNCNGSPFANSDACF
SLAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILEDMYHAIKNEEIVMPEEQTGLVRENYVWNVLLHRGATPEGIF
LRVPTASYDLDLFTMTWGPTIAALSYVFDKSLEETIIQKAISGFRKCAMISAHYGLSDVFDNLIISLCKFTALSSESIENLPSVFGSNPK
AHIAAKTVFHLAHRHGDILREGWKNIMEAMLQLFRAQLLPKAMIEVEDFVDPNGKISLQREETPSNRGESTVLSFVSWLTLSGPEQSSVR
GPSTENQEAKRVALECIKQCDPEKMITESKFLQLESLQELMKALVSVTPDEETYDEEDAAFCLEMLLRIVLENRDRVGCVWQTVRDHLYH
LCVQAQDFCFLVERAVVGLLRLAIRLLRREEISAQVLLSLRILLLMKPSVLSRVSHQVAYGLHELLKTNAANIHSGDDWATLFTLLECIG
SGVKPPAALQATARADAPDAGAQSDSELPSYHQNDVSLDRGYTSDSEVYTDHGRPGKIHRSATDADVVNSGWLVVGKDDVDNSKPGPSRP
GPSPLINQYSLTVGLDLGPHDTKSLLKCVESLSFIVRDAAHITPDNFELCVKTLRIFVEASLNGGCKSQEKRGKSHKYDSKGNRFKKKSK
EGSMLRRPRTSSQHASRGGQSDDDEDEGVPASYHTVSLQVSQDLLDLMHTLHTRAASIYSSWAEEQRHLETGGQKIEADSRTLWAHCWCP
LLQGIACLCCDARRQVRMQALTYLQRALLVHDLQKLDALEWESCFNKVLFPLLTKLLENISPADVGGMEETRMRASTLLSKVFLQHLSPL
LSLSTFAALWLTILDFMDKYMHAGSSDLLSEAIPESLKNMLLVMDTAEIFHSADARGGGPSALWEITWERIDCFLPHLRDELFKQTVIQD
PMPMEPQGQKPLASAHLTSAAGDTRTPGHPPPPEIPSELGACDFEKPESPRAASSSSPGSPVASSPSRLSPTPDGPPPLAQPPLILQPLA

--------------------------------------------------------------
>87983_87983_2_SUFU-GBF1_SUFU_chr10_104309863_ENST00000369902_GBF1_chr10_104111013_ENST00000369983_length(transcript)=6468nt_BP=620nt
GACAGCCTGGGCGGACAGTGCGCCGTGCGCAGGCGCGGAGCTAGACCTCGCTGCAGCCCCCATCGCCTCGGGGAGTCTCACCCACCGAGT
CCGCCCGCTGGCCCGTCAGTGCTCTCCCCGTCGTTTGCCCTCTCCAGTTCCCCCAGTGCCTGCCCTACGCACCCCGATGGCGGAGCTGCG
GCCTAGCGGCGCCCCCGGCCCCACCGCGCCCCCGGCCCCTGGCCCGACTGCCCCCCCGGCCTTCGCTTCGCTCTTTCCCCCGGGACTGCA
CGCCATCTACGGAGAGTGCCGCCGCCTTTACCCTGACCAGCCGAACCCGCTCCAGGTTACCGCTATCGTCAAGTACTGGTTGGGTGGCCC
AGACCCCTTGGACTATGTTAGCATGTACAGGAATGTGGGGAGCCCTTCTGCTAACATCCCCGAGCACTGGCACTACATCAGCTTCGGCCT
GAGTGATCTCTATGGTGACAACAGAGTCCATGAGTTTACAGGAACAGATGGACCTAGTGGTTTTGGCTTTGAGTTGACCTTTCGTCTGAA
GAGAGAAACTGGGGAGTCTGCCCCACCAACATGGCCCGCAGAGTTAATGCAGGGCTTGGCACGATACGTGTTCCAGTCAGATCCCACCCA
TGAGGGCACAGCAGAGGGCATGGAGAACATGGCAGATGCTGTCACCCATGCTCGTTTTGTGGGCACGGATCCTGCCAGTGATGAAGTTGT
CCTGATGAAAATCCTTCAGGTTCTACGGACTCTGCTGCTAACCCCAGTGGGTGCCCACCTAACCAATGAATCTGTGTGTGAGATTATGCA
GTCTTGCTTCCGGATCTGCTTTGAAATGAGGCTCAGTGAGTTATTGAGAAAATCCGCAGAGCACACTCTCGTAGACATGGTGCAGCTGCT
CTTCACAAGGTTACCTCAGTTTAAAGAAGAACCCAAGAACTATGTGGGGACCAACATGAAGAAGCTGAAAATGAGAGCCGGAGGCATGAG
TGATTCATCCAAATGGAAGAAACAGAAGAGATCCCCTCGGCCCCCACGCCATATGACCAAAGTCACACCAGGTTCAGAGCTGCCCACTCC
CAATGGAACCACCTTATCATCTAACCTCACTGGTGGCATGCCCTTCATTGATGTGCCCACTCCCATCTCCTCTGCAAGTTCAGAAGCTGC
CTCAGCAGTGGTCAGTCCCTCTACAGACAGTGGCCTGGAATTCTCCTCCCAAACCACTTCCAAGGAAGACCTTACTGATCTAGAGCAACC
TGGCTCTCCAGGGTACAGCACAGCTACAGAGCCTGGAAGCAGTGAGCTAGGTGTTCCCGAGCAGCCTGACCTCCAGGAAGGGACCCATGT
GGAAAAGTCCCAGTCAGCATCTGTGGAGTCCATCCCTGAAGTGTTAGAGGAGTGCACGTCCCCTGCCGACCACTCTGACTCTGCCTCTGT
CCATGACATGGATTACGTCAATCCCCGGGGCGTGCGCTTTACACAGTCCTCCCAGAAAGAAGGCACAGCTTTGGTCCCCTATGGTCTTCC
CTGCATCCGCGAGCTCTTCCGCTTCCTCATCTCCCTCACCAATCCACACGACCGCCATAACTCAGAGGTTATGATTCACATGGGACTGCA
TTTGCTGACAGTGGCCCTTGAGTCAGCCCCTGTAGCCCAGTGCCAGACCCTCTTGGGCCTCATCAAGGATGAGATGTGCCGTCACTTATT
CCAGCTACTCAGCATAGAGCGACTAAACCTTTATGCTGCTTCCCTGCGAGTATGCTTCCTACTGTTTGAGAGCATGCGAGAGCACCTCAA
GTTCCAAATGGAGATGTACATCAAAAAGCTTATGGAGATCATCACTGTGGAGAACCCCAAGATGCCTTATGAGATGAAGGAGATGGCACT
GGAGGCCATTGTGCAGCTCTGGCGCATCCCCAGCTTTGTCACAGAGCTCTACATCAACTATGATTGTGACTACTACTGTTCCAACCTCTT
TGAGGAACTCACAAAGCTGCTGTCCAAGAATGCCTTCCCTGTGTCTGGTCAACTCTATACAACACACCTACTATCTCTTGATGCCCTATT
GACAGTGATTGACAGCACCGAGGCCCACTGCCAGGCTAAAGTCCTCAACAGCCTCACCCAGCAAGAGAAGAAGGAGACAGCCAGACCAAG
CTGTGAGATAGTAGATGGCACCCGAGAAGCTAGCAATACTGAGAGAACTGCCAGCGATGGGAAAGCTGTAGGCATGGCCTCAGACATCCC
AGGCCTGCATCTGCCAGGTGGAGGGCGGCTGCCACCAGAACATGGGAAATCAGGATGCAGTGATCTGGAGGAAGCTGTTGACTCTGGGGC
TGACAAAAAGTTTGCCCGGAAGCCACCCCGATTTTCCTGTCTCCTGCCAGATCCACGGGAACTAATTGAAATTAAAAACAAAAAGAAGCT
GCTAATCACTGGCACAGAGCAGTTCAATCAGAAACCAAAGAAGGGGATTCAGTTTCTGCAAGAGAAAGGCCTCCTCACCATCCCAATGGA
CAACACAGAGGTTGCTCAGTGGCTCCGAGAGAACCCTCGGCTGGACAAGAAGATGATTGGAGAGTTTGTGAGTGACCGCAAAAACATTGA
CCTGTTGGAGAGCTTTGTGAGCACCTTCAGTTTTCAGGGTCTGCGACTGGACGAAGCCCTCCGCCTCTACCTGGAAGCCTTCCGTTTGCC
TGGGGAAGCACCAGTCATCCAGAGGTTGCTGGAGGCATTCACAGAGCGTTGGATGAATTGTAATGGCTCCCCATTTGCCAATAGCGATGC
CTGCTTTTCCCTGGCCTATGCTGTCATCATGCTTAATACTGACCAGCACAACCACAATGTTCGTAAACAGAATGCACCCATGACCCTGGA
GGAGTTTCGCAAAAATCTGAAAGGTGTGAATGGAGGCAAGGACTTTGAGCAAGACATCCTGGAGGACATGTACCATGCCATCAAGAATGA
GGAAATTGTAATGCCTGAGGAGCAGACAGGCTTGGTTCGGGAGAACTATGTGTGGAATGTGCTGCTTCATCGAGGTGCCACCCCTGAGGG
CATATTCCTGCGTGTGCCTACTGCCAGCTATGATCTTGACCTCTTCACCATGACCTGGGGCCCCACTATTGCTGCTCTCTCTTATGTCTT
TGACAAAAGCCTTGAGGAGACAATCATCCAGAAAGCCATCTCAGGCTTCAGGAAGTGCGCCATGATCTCCGCCCACTATGGCCTCAGCGA
TGTGTTTGACAATCTCATCATCTCTCTATGCAAATTCACAGCTCTCAGCAGTGAGTCTATTGAGAACCTGCCCAGTGTATTTGGAAGCAA
CCCTAAAGCCCATATTGCAGCCAAGACAGTATTCCATTTGGCCCATCGTCATGGTGACATCCTGCGGGAGGGCTGGAAGAATATCATGGA
GGCCATGCTGCAGCTCTTCCGAGCCCAACTACTGCCCAAGGCTATGATAGAGGTAGAAGATTTCGTGGATCCCAATGGCAAGATCTCTCT
ACAGCGGGAAGAGACACCATCAAACCGAGGAGAGTCAACAGTGCTGAGCTTTGTGAGCTGGCTAACACTGAGTGGTCCTGAGCAGTCTAG
TGTTCGGGGCCCATCCACTGAAAACCAAGAGGCCAAGAGAGTGGCCTTAGAGTGTATAAAGCAATGTGACCCAGAAAAAATGATCACAGA
AAGCAAGTTCCTCCAGCTGGAGTCACTACAGGAGCTCATGAAGGCTCTGGTCTCAGTGACACCAGATGAAGAGACATATGATGAGGAAGA
TGCTGCTTTCTGCCTAGAGATGCTGCTAAGGATTGTGTTGGAGAACAGGGATCGTGTGGGCTGTGTGTGGCAGACTGTTCGAGACCATCT
ATACCACCTCTGTGTTCAGGCACAAGATTTCTGCTTCCTTGTGGAGCGGGCAGTGGTGGGGTTGCTACGCCTGGCCATTCGGCTTCTCCG
GAGAGAAGAGATCAGTGCTCAGGTGCTGCTCTCCCTGCGCATTTTGCTACTGATGAAGCCCAGTGTGCTATCCCGAGTCAGCCACCAGGT
TGCGTATGGGCTCCATGAACTCCTGAAGACCAATGCAGCCAACATCCACTCAGGTGATGACTGGGCCACACTCTTCACACTGCTGGAGTG
CATCGGCTCAGGTGTGAAGCCTCCAGCTGCTCTGCAGGCCACAGCCAGGGCAGATGCACCTGATGCCGGGGCCCAGTCAGATAGTGAGCT
CCCATCCTACCATCAGAATGACGTGAGCCTGGATCGAGGGTACACTTCCGACTCAGAGGTCTACACTGACCATGGCAGGCCGGGCAAGAT
ACACCGATCAGCCACAGATGCCGATGTGGTCAACAGTGGTTGGTTAGTGGTTGGGAAGGATGACGTTGATAACTCCAAGCCAGGGCCCAG
CCGCCCAGGCCCTTCACCCCTGATCAATCAATACAGCCTAACAGTGGGACTGGATTTGGGGCCACACGACACTAAGTCTCTGCTTAAGTG
TGTGGAATCGCTGTCCTTCATTGTGCGTGATGCTGCCCACATCACACCTGACAACTTTGAGCTCTGCGTCAAGACTCTCCGGATCTTTGT
GGAGGCCAGTCTGAATGGCGGATGCAAGTCCCAGGAGAAACGTGGCAAGAGTCACAAATATGACAGCAAAGGGAACCGCTTCAAGAAGAA
ATCCAAAGAGGGATCAATGCTTCGCCGGCCTCGAACCTCCAGCCAACATGCCTCTCGGGGCGGGCAGAGTGATGATGATGAGGACGAAGG
CGTGCCTGCCAGCTACCATACGGTGTCTTTACAGGTCAGTCAGGACTTGCTAGACCTGATGCACACCCTGCACACGCGGGCAGCCTCTAT
CTACAGCTCATGGGCGGAGGAGCAACGCCACCTGGAGACAGGTGGCCAGAAGATTGAAGCTGATTCTCGCACCCTCTGGGCCCACTGCTG
GTGCCCTTTACTGCAGGGTATTGCCTGCCTGTGCTGCGATGCCCGGCGCCAGGTACGGATGCAGGCACTGACCTATCTGCAGCGAGCACT
ACTTGTACATGATCTGCAAAAGCTAGATGCCCTGGAATGGGAGTCCTGTTTTAACAAGGTGCTGTTTCCTCTACTTACCAAGCTCTTGGA
GAACATCAGCCCTGCAGATGTGGGTGGGATGGAGGAGACCCGGATGAGGGCTTCCACATTGCTCTCTAAGGTCTTCCTGCAGCACCTGTC
TCCACTGCTGTCACTCTCTACCTTTGCGGCCCTCTGGCTCACCATCTTGGACTTCATGGACAAGTACATGCACGCAGGCTCCAGCGACTT
ACTGTCAGAGGCGATCCCTGAGTCTCTGAAGAACATGCTTCTGGTGATGGACACAGCGGAGATTTTCCACAGTGCAGATGCACGGGGAGG
CGGCCCCTCGGCCCTCTGGGAGATCACCTGGGAACGCATTGACTGTTTTCTCCCTCACCTACGAGATGAACTCTTCAAGCAGACCGTCAT
CCAGGACCCCATGCCCATGGAGCCTCAAGGCCAAAAGCCTCTCGCCTCAGCCCACCTGACTTCCGCTGCTGGCGACACTAGGACACCTGG
CCATCCACCGCCCCCAGAGATTCCATCTGAGCTGGGGGCCTGTGACTTTGAGAAGCCCGAGAGCCCCCGAGCCGCCAGCAGCAGCTCCCC
AGGATCACCAGTGGCCTCAAGCCCCAGCAGGCTGAGCCCCACCCCCGACGGGCCTCCACCCTTGGCTCAGCCCCCACTGATCCTGCAGCC
CTTGGCCTCCCCACTGCAGGTGGGCGTGCCACCTATGACTCTGCCCATCATCCTCAACCCTGCGCTCATCGAGGCCACCTCACCAGTGCC
CCTCCTGGCCACACCCCGCCCCACAGATCCCATACCCACCTCTGAGGTCAACTAAGGCAGGTCACTCAGAGATCAGGACCAGTGCTTCCC
ACCAGGCTTTCCTTGACCCCACTTCTGGCTGTCCTGCGGGCCACAAGCTCTTCAGGCCAAGTCAGAGCTGCTGTTGCTGCCACTTGGATG
GGGACCTGAAAAAGAGAATGTTGATAGCCCCAGCTAAGACCCCCAATCAGCTGTGGGACCTTTTTCCTCCTCTGCGCTCCATTCCTGGGG
GTTCAGCCTGAGAGTGAACTCAGCTGTCATCTGCAGCCTCTGCCTCCAGCCCGGCAGCTCTGGGGAGGCATCCGTGTGCCGGCCCTGCAG
TGCCTGCCCACGGTCAGGCATTGAAAACTAAGCCCAACCACTCTGCACTTTGTTTCCCACTCCCATTAGCCCTGGGCCACCTCCTCCAGT
TCTTCCTCTTTTACTAATTAGTTGGTCAGTTTGGAGAGTTGACTGGCACCATGGAGGGTAGGCAGGTGGGGGCTGGGTGGGGGACTGCCC

>87983_87983_2_SUFU-GBF1_SUFU_chr10_104309863_ENST00000369902_GBF1_chr10_104111013_ENST00000369983_length(amino acids)=1935AA_BP=174
MARQCSPRRLPSPVPPVPALRTPMAELRPSGAPGPTAPPAPGPTAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGGPDP
LDYVSMYRNVGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSDPTHEG
TAEGMENMADAVTHARFVGTDPASDEVVLMKILQVLRTLLLTPVGAHLTNESVCEIMQSCFRICFEMRLSELLRKSAEHTLVDMVQLLFT
RLPQFKEEPKNYVGTNMKKLKMRAGGMSDSSKWKKQKRSPRPPRHMTKVTPGSELPTPNGTTLSSNLTGGMPFIDVPTPISSASSEAASA
VVSPSTDSGLEFSSQTTSKEDLTDLEQPGSPGYSTATEPGSSELGVPEQPDLQEGTHVEKSQSASVESIPEVLEECTSPADHSDSASVHD
MDYVNPRGVRFTQSSQKEGTALVPYGLPCIRELFRFLISLTNPHDRHNSEVMIHMGLHLLTVALESAPVAQCQTLLGLIKDEMCRHLFQL
LSIERLNLYAASLRVCFLLFESMREHLKFQMEMYIKKLMEIITVENPKMPYEMKEMALEAIVQLWRIPSFVTELYINYDCDYYCSNLFEE
LTKLLSKNAFPVSGQLYTTHLLSLDALLTVIDSTEAHCQAKVLNSLTQQEKKETARPSCEIVDGTREASNTERTASDGKAVGMASDIPGL
HLPGGGRLPPEHGKSGCSDLEEAVDSGADKKFARKPPRFSCLLPDPRELIEIKNKKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNT
EVAQWLRENPRLDKKMIGEFVSDRKNIDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIQRLLEAFTERWMNCNGSPFANSDACF
SLAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILEDMYHAIKNEEIVMPEEQTGLVRENYVWNVLLHRGATPEGIF
LRVPTASYDLDLFTMTWGPTIAALSYVFDKSLEETIIQKAISGFRKCAMISAHYGLSDVFDNLIISLCKFTALSSESIENLPSVFGSNPK
AHIAAKTVFHLAHRHGDILREGWKNIMEAMLQLFRAQLLPKAMIEVEDFVDPNGKISLQREETPSNRGESTVLSFVSWLTLSGPEQSSVR
GPSTENQEAKRVALECIKQCDPEKMITESKFLQLESLQELMKALVSVTPDEETYDEEDAAFCLEMLLRIVLENRDRVGCVWQTVRDHLYH
LCVQAQDFCFLVERAVVGLLRLAIRLLRREEISAQVLLSLRILLLMKPSVLSRVSHQVAYGLHELLKTNAANIHSGDDWATLFTLLECIG
SGVKPPAALQATARADAPDAGAQSDSELPSYHQNDVSLDRGYTSDSEVYTDHGRPGKIHRSATDADVVNSGWLVVGKDDVDNSKPGPSRP
GPSPLINQYSLTVGLDLGPHDTKSLLKCVESLSFIVRDAAHITPDNFELCVKTLRIFVEASLNGGCKSQEKRGKSHKYDSKGNRFKKKSK
EGSMLRRPRTSSQHASRGGQSDDDEDEGVPASYHTVSLQVSQDLLDLMHTLHTRAASIYSSWAEEQRHLETGGQKIEADSRTLWAHCWCP
LLQGIACLCCDARRQVRMQALTYLQRALLVHDLQKLDALEWESCFNKVLFPLLTKLLENISPADVGGMEETRMRASTLLSKVFLQHLSPL
LSLSTFAALWLTILDFMDKYMHAGSSDLLSEAIPESLKNMLLVMDTAEIFHSADARGGGPSALWEITWERIDCFLPHLRDELFKQTVIQD
PMPMEPQGQKPLASAHLTSAAGDTRTPGHPPPPEIPSELGACDFEKPESPRAASSSSPGSPVASSPSRLSPTPDGPPPLAQPPLILQPLA

--------------------------------------------------------------
>87983_87983_3_SUFU-GBF1_SUFU_chr10_104309863_ENST00000423559_GBF1_chr10_104111013_ENST00000369983_length(transcript)=6376nt_BP=528nt
GCCCGCTGGCCCGTCAGTGCTCTCCCCGTCGTTTGCCCTCTCCAGTTCCCCCAGTGCCTGCCCTACGCACCCCGATGGCGGAGCTGCGGC
CTAGCGGCGCCCCCGGCCCCACCGCGCCCCCGGCCCCTGGCCCGACTGCCCCCCCGGCCTTCGCTTCGCTCTTTCCCCCGGGACTGCACG
CCATCTACGGAGAGTGCCGCCGCCTTTACCCTGACCAGCCGAACCCGCTCCAGGTTACCGCTATCGTCAAGTACTGGTTGGGTGGCCCAG
ACCCCTTGGACTATGTTAGCATGTACAGGAATGTGGGGAGCCCTTCTGCTAACATCCCCGAGCACTGGCACTACATCAGCTTCGGCCTGA
GTGATCTCTATGGTGACAACAGAGTCCATGAGTTTACAGGAACAGATGGACCTAGTGGTTTTGGCTTTGAGTTGACCTTTCGTCTGAAGA
GAGAAACTGGGGAGTCTGCCCCACCAACATGGCCCGCAGAGTTAATGCAGGGCTTGGCACGATACGTGTTCCAGTCAGATCCCACCCATG
AGGGCACAGCAGAGGGCATGGAGAACATGGCAGATGCTGTCACCCATGCTCGTTTTGTGGGCACGGATCCTGCCAGTGATGAAGTTGTCC
TGATGAAAATCCTTCAGGTTCTACGGACTCTGCTGCTAACCCCAGTGGGTGCCCACCTAACCAATGAATCTGTGTGTGAGATTATGCAGT
CTTGCTTCCGGATCTGCTTTGAAATGAGGCTCAGTGAGTTATTGAGAAAATCCGCAGAGCACACTCTCGTAGACATGGTGCAGCTGCTCT
TCACAAGGTTACCTCAGTTTAAAGAAGAACCCAAGAACTATGTGGGGACCAACATGAAGAAGCTGAAAATGAGAGCCGGAGGCATGAGTG
ATTCATCCAAATGGAAGAAACAGAAGAGATCCCCTCGGCCCCCACGCCATATGACCAAAGTCACACCAGGTTCAGAGCTGCCCACTCCCA
ATGGAACCACCTTATCATCTAACCTCACTGGTGGCATGCCCTTCATTGATGTGCCCACTCCCATCTCCTCTGCAAGTTCAGAAGCTGCCT
CAGCAGTGGTCAGTCCCTCTACAGACAGTGGCCTGGAATTCTCCTCCCAAACCACTTCCAAGGAAGACCTTACTGATCTAGAGCAACCTG
GCTCTCCAGGGTACAGCACAGCTACAGAGCCTGGAAGCAGTGAGCTAGGTGTTCCCGAGCAGCCTGACCTCCAGGAAGGGACCCATGTGG
AAAAGTCCCAGTCAGCATCTGTGGAGTCCATCCCTGAAGTGTTAGAGGAGTGCACGTCCCCTGCCGACCACTCTGACTCTGCCTCTGTCC
ATGACATGGATTACGTCAATCCCCGGGGCGTGCGCTTTACACAGTCCTCCCAGAAAGAAGGCACAGCTTTGGTCCCCTATGGTCTTCCCT
GCATCCGCGAGCTCTTCCGCTTCCTCATCTCCCTCACCAATCCACACGACCGCCATAACTCAGAGGTTATGATTCACATGGGACTGCATT
TGCTGACAGTGGCCCTTGAGTCAGCCCCTGTAGCCCAGTGCCAGACCCTCTTGGGCCTCATCAAGGATGAGATGTGCCGTCACTTATTCC
AGCTACTCAGCATAGAGCGACTAAACCTTTATGCTGCTTCCCTGCGAGTATGCTTCCTACTGTTTGAGAGCATGCGAGAGCACCTCAAGT
TCCAAATGGAGATGTACATCAAAAAGCTTATGGAGATCATCACTGTGGAGAACCCCAAGATGCCTTATGAGATGAAGGAGATGGCACTGG
AGGCCATTGTGCAGCTCTGGCGCATCCCCAGCTTTGTCACAGAGCTCTACATCAACTATGATTGTGACTACTACTGTTCCAACCTCTTTG
AGGAACTCACAAAGCTGCTGTCCAAGAATGCCTTCCCTGTGTCTGGTCAACTCTATACAACACACCTACTATCTCTTGATGCCCTATTGA
CAGTGATTGACAGCACCGAGGCCCACTGCCAGGCTAAAGTCCTCAACAGCCTCACCCAGCAAGAGAAGAAGGAGACAGCCAGACCAAGCT
GTGAGATAGTAGATGGCACCCGAGAAGCTAGCAATACTGAGAGAACTGCCAGCGATGGGAAAGCTGTAGGCATGGCCTCAGACATCCCAG
GCCTGCATCTGCCAGGTGGAGGGCGGCTGCCACCAGAACATGGGAAATCAGGATGCAGTGATCTGGAGGAAGCTGTTGACTCTGGGGCTG
ACAAAAAGTTTGCCCGGAAGCCACCCCGATTTTCCTGTCTCCTGCCAGATCCACGGGAACTAATTGAAATTAAAAACAAAAAGAAGCTGC
TAATCACTGGCACAGAGCAGTTCAATCAGAAACCAAAGAAGGGGATTCAGTTTCTGCAAGAGAAAGGCCTCCTCACCATCCCAATGGACA
ACACAGAGGTTGCTCAGTGGCTCCGAGAGAACCCTCGGCTGGACAAGAAGATGATTGGAGAGTTTGTGAGTGACCGCAAAAACATTGACC
TGTTGGAGAGCTTTGTGAGCACCTTCAGTTTTCAGGGTCTGCGACTGGACGAAGCCCTCCGCCTCTACCTGGAAGCCTTCCGTTTGCCTG
GGGAAGCACCAGTCATCCAGAGGTTGCTGGAGGCATTCACAGAGCGTTGGATGAATTGTAATGGCTCCCCATTTGCCAATAGCGATGCCT
GCTTTTCCCTGGCCTATGCTGTCATCATGCTTAATACTGACCAGCACAACCACAATGTTCGTAAACAGAATGCACCCATGACCCTGGAGG
AGTTTCGCAAAAATCTGAAAGGTGTGAATGGAGGCAAGGACTTTGAGCAAGACATCCTGGAGGACATGTACCATGCCATCAAGAATGAGG
AAATTGTAATGCCTGAGGAGCAGACAGGCTTGGTTCGGGAGAACTATGTGTGGAATGTGCTGCTTCATCGAGGTGCCACCCCTGAGGGCA
TATTCCTGCGTGTGCCTACTGCCAGCTATGATCTTGACCTCTTCACCATGACCTGGGGCCCCACTATTGCTGCTCTCTCTTATGTCTTTG
ACAAAAGCCTTGAGGAGACAATCATCCAGAAAGCCATCTCAGGCTTCAGGAAGTGCGCCATGATCTCCGCCCACTATGGCCTCAGCGATG
TGTTTGACAATCTCATCATCTCTCTATGCAAATTCACAGCTCTCAGCAGTGAGTCTATTGAGAACCTGCCCAGTGTATTTGGAAGCAACC
CTAAAGCCCATATTGCAGCCAAGACAGTATTCCATTTGGCCCATCGTCATGGTGACATCCTGCGGGAGGGCTGGAAGAATATCATGGAGG
CCATGCTGCAGCTCTTCCGAGCCCAACTACTGCCCAAGGCTATGATAGAGGTAGAAGATTTCGTGGATCCCAATGGCAAGATCTCTCTAC
AGCGGGAAGAGACACCATCAAACCGAGGAGAGTCAACAGTGCTGAGCTTTGTGAGCTGGCTAACACTGAGTGGTCCTGAGCAGTCTAGTG
TTCGGGGCCCATCCACTGAAAACCAAGAGGCCAAGAGAGTGGCCTTAGAGTGTATAAAGCAATGTGACCCAGAAAAAATGATCACAGAAA
GCAAGTTCCTCCAGCTGGAGTCACTACAGGAGCTCATGAAGGCTCTGGTCTCAGTGACACCAGATGAAGAGACATATGATGAGGAAGATG
CTGCTTTCTGCCTAGAGATGCTGCTAAGGATTGTGTTGGAGAACAGGGATCGTGTGGGCTGTGTGTGGCAGACTGTTCGAGACCATCTAT
ACCACCTCTGTGTTCAGGCACAAGATTTCTGCTTCCTTGTGGAGCGGGCAGTGGTGGGGTTGCTACGCCTGGCCATTCGGCTTCTCCGGA
GAGAAGAGATCAGTGCTCAGGTGCTGCTCTCCCTGCGCATTTTGCTACTGATGAAGCCCAGTGTGCTATCCCGAGTCAGCCACCAGGTTG
CGTATGGGCTCCATGAACTCCTGAAGACCAATGCAGCCAACATCCACTCAGGTGATGACTGGGCCACACTCTTCACACTGCTGGAGTGCA
TCGGCTCAGGTGTGAAGCCTCCAGCTGCTCTGCAGGCCACAGCCAGGGCAGATGCACCTGATGCCGGGGCCCAGTCAGATAGTGAGCTCC
CATCCTACCATCAGAATGACGTGAGCCTGGATCGAGGGTACACTTCCGACTCAGAGGTCTACACTGACCATGGCAGGCCGGGCAAGATAC
ACCGATCAGCCACAGATGCCGATGTGGTCAACAGTGGTTGGTTAGTGGTTGGGAAGGATGACGTTGATAACTCCAAGCCAGGGCCCAGCC
GCCCAGGCCCTTCACCCCTGATCAATCAATACAGCCTAACAGTGGGACTGGATTTGGGGCCACACGACACTAAGTCTCTGCTTAAGTGTG
TGGAATCGCTGTCCTTCATTGTGCGTGATGCTGCCCACATCACACCTGACAACTTTGAGCTCTGCGTCAAGACTCTCCGGATCTTTGTGG
AGGCCAGTCTGAATGGCGGATGCAAGTCCCAGGAGAAACGTGGCAAGAGTCACAAATATGACAGCAAAGGGAACCGCTTCAAGAAGAAAT
CCAAAGAGGGATCAATGCTTCGCCGGCCTCGAACCTCCAGCCAACATGCCTCTCGGGGCGGGCAGAGTGATGATGATGAGGACGAAGGCG
TGCCTGCCAGCTACCATACGGTGTCTTTACAGGTCAGTCAGGACTTGCTAGACCTGATGCACACCCTGCACACGCGGGCAGCCTCTATCT
ACAGCTCATGGGCGGAGGAGCAACGCCACCTGGAGACAGGTGGCCAGAAGATTGAAGCTGATTCTCGCACCCTCTGGGCCCACTGCTGGT
GCCCTTTACTGCAGGGTATTGCCTGCCTGTGCTGCGATGCCCGGCGCCAGGTACGGATGCAGGCACTGACCTATCTGCAGCGAGCACTAC
TTGTACATGATCTGCAAAAGCTAGATGCCCTGGAATGGGAGTCCTGTTTTAACAAGGTGCTGTTTCCTCTACTTACCAAGCTCTTGGAGA
ACATCAGCCCTGCAGATGTGGGTGGGATGGAGGAGACCCGGATGAGGGCTTCCACATTGCTCTCTAAGGTCTTCCTGCAGCACCTGTCTC
CACTGCTGTCACTCTCTACCTTTGCGGCCCTCTGGCTCACCATCTTGGACTTCATGGACAAGTACATGCACGCAGGCTCCAGCGACTTAC
TGTCAGAGGCGATCCCTGAGTCTCTGAAGAACATGCTTCTGGTGATGGACACAGCGGAGATTTTCCACAGTGCAGATGCACGGGGAGGCG
GCCCCTCGGCCCTCTGGGAGATCACCTGGGAACGCATTGACTGTTTTCTCCCTCACCTACGAGATGAACTCTTCAAGCAGACCGTCATCC
AGGACCCCATGCCCATGGAGCCTCAAGGCCAAAAGCCTCTCGCCTCAGCCCACCTGACTTCCGCTGCTGGCGACACTAGGACACCTGGCC
ATCCACCGCCCCCAGAGATTCCATCTGAGCTGGGGGCCTGTGACTTTGAGAAGCCCGAGAGCCCCCGAGCCGCCAGCAGCAGCTCCCCAG
GATCACCAGTGGCCTCAAGCCCCAGCAGGCTGAGCCCCACCCCCGACGGGCCTCCACCCTTGGCTCAGCCCCCACTGATCCTGCAGCCCT
TGGCCTCCCCACTGCAGGTGGGCGTGCCACCTATGACTCTGCCCATCATCCTCAACCCTGCGCTCATCGAGGCCACCTCACCAGTGCCCC
TCCTGGCCACACCCCGCCCCACAGATCCCATACCCACCTCTGAGGTCAACTAAGGCAGGTCACTCAGAGATCAGGACCAGTGCTTCCCAC
CAGGCTTTCCTTGACCCCACTTCTGGCTGTCCTGCGGGCCACAAGCTCTTCAGGCCAAGTCAGAGCTGCTGTTGCTGCCACTTGGATGGG
GACCTGAAAAAGAGAATGTTGATAGCCCCAGCTAAGACCCCCAATCAGCTGTGGGACCTTTTTCCTCCTCTGCGCTCCATTCCTGGGGGT
TCAGCCTGAGAGTGAACTCAGCTGTCATCTGCAGCCTCTGCCTCCAGCCCGGCAGCTCTGGGGAGGCATCCGTGTGCCGGCCCTGCAGTG
CCTGCCCACGGTCAGGCATTGAAAACTAAGCCCAACCACTCTGCACTTTGTTTCCCACTCCCATTAGCCCTGGGCCACCTCCTCCAGTTC
TTCCTCTTTTACTAATTAGTTGGTCAGTTTGGAGAGTTGACTGGCACCATGGAGGGTAGGCAGGTGGGGGCTGGGTGGGGGACTGCCCAC

>87983_87983_3_SUFU-GBF1_SUFU_chr10_104309863_ENST00000423559_GBF1_chr10_104111013_ENST00000369983_length(amino acids)=1935AA_BP=174
MARQCSPRRLPSPVPPVPALRTPMAELRPSGAPGPTAPPAPGPTAPPAFASLFPPGLHAIYGECRRLYPDQPNPLQVTAIVKYWLGGPDP
LDYVSMYRNVGSPSANIPEHWHYISFGLSDLYGDNRVHEFTGTDGPSGFGFELTFRLKRETGESAPPTWPAELMQGLARYVFQSDPTHEG
TAEGMENMADAVTHARFVGTDPASDEVVLMKILQVLRTLLLTPVGAHLTNESVCEIMQSCFRICFEMRLSELLRKSAEHTLVDMVQLLFT
RLPQFKEEPKNYVGTNMKKLKMRAGGMSDSSKWKKQKRSPRPPRHMTKVTPGSELPTPNGTTLSSNLTGGMPFIDVPTPISSASSEAASA
VVSPSTDSGLEFSSQTTSKEDLTDLEQPGSPGYSTATEPGSSELGVPEQPDLQEGTHVEKSQSASVESIPEVLEECTSPADHSDSASVHD
MDYVNPRGVRFTQSSQKEGTALVPYGLPCIRELFRFLISLTNPHDRHNSEVMIHMGLHLLTVALESAPVAQCQTLLGLIKDEMCRHLFQL
LSIERLNLYAASLRVCFLLFESMREHLKFQMEMYIKKLMEIITVENPKMPYEMKEMALEAIVQLWRIPSFVTELYINYDCDYYCSNLFEE
LTKLLSKNAFPVSGQLYTTHLLSLDALLTVIDSTEAHCQAKVLNSLTQQEKKETARPSCEIVDGTREASNTERTASDGKAVGMASDIPGL
HLPGGGRLPPEHGKSGCSDLEEAVDSGADKKFARKPPRFSCLLPDPRELIEIKNKKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNT
EVAQWLRENPRLDKKMIGEFVSDRKNIDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIQRLLEAFTERWMNCNGSPFANSDACF
SLAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILEDMYHAIKNEEIVMPEEQTGLVRENYVWNVLLHRGATPEGIF
LRVPTASYDLDLFTMTWGPTIAALSYVFDKSLEETIIQKAISGFRKCAMISAHYGLSDVFDNLIISLCKFTALSSESIENLPSVFGSNPK
AHIAAKTVFHLAHRHGDILREGWKNIMEAMLQLFRAQLLPKAMIEVEDFVDPNGKISLQREETPSNRGESTVLSFVSWLTLSGPEQSSVR
GPSTENQEAKRVALECIKQCDPEKMITESKFLQLESLQELMKALVSVTPDEETYDEEDAAFCLEMLLRIVLENRDRVGCVWQTVRDHLYH
LCVQAQDFCFLVERAVVGLLRLAIRLLRREEISAQVLLSLRILLLMKPSVLSRVSHQVAYGLHELLKTNAANIHSGDDWATLFTLLECIG
SGVKPPAALQATARADAPDAGAQSDSELPSYHQNDVSLDRGYTSDSEVYTDHGRPGKIHRSATDADVVNSGWLVVGKDDVDNSKPGPSRP
GPSPLINQYSLTVGLDLGPHDTKSLLKCVESLSFIVRDAAHITPDNFELCVKTLRIFVEASLNGGCKSQEKRGKSHKYDSKGNRFKKKSK
EGSMLRRPRTSSQHASRGGQSDDDEDEGVPASYHTVSLQVSQDLLDLMHTLHTRAASIYSSWAEEQRHLETGGQKIEADSRTLWAHCWCP
LLQGIACLCCDARRQVRMQALTYLQRALLVHDLQKLDALEWESCFNKVLFPLLTKLLENISPADVGGMEETRMRASTLLSKVFLQHLSPL
LSLSTFAALWLTILDFMDKYMHAGSSDLLSEAIPESLKNMLLVMDTAEIFHSADARGGGPSALWEITWERIDCFLPHLRDELFKQTVIQD
PMPMEPQGQKPLASAHLTSAAGDTRTPGHPPPPEIPSELGACDFEKPESPRAASSSSPGSPVASSPSRLSPTPDGPPPLAQPPLILQPLA

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Fusion Gene PPI Analysis for SUFU-GBF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneGBF1chr10:104309863chr10:104111013ENST000003699833401_38098.333333333333331860.0RAB1B


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SUFU-GBF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SUFU-GBF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource