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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SUGP2-FAM227B (FusionGDB2 ID:88004)

Fusion Gene Summary for SUGP2-FAM227B

check button Fusion gene summary
Fusion gene informationFusion gene name: SUGP2-FAM227B
Fusion gene ID: 88004
HgeneTgene
Gene symbol

SUGP2

FAM227B

Gene ID

10147

196951

Gene nameSURP and G-patch domain containing 2family with sequence similarity 227 member B
SynonymsSFRS14|SRFS14C15orf33
Cytomap

19p13.11

15q21.2

Type of geneprotein-codingprotein-coding
DescriptionSURP and G-patch domain-containing protein 2arginine/serine-rich-splicing factor 14splicing factor, arginine/serine-rich 14protein FAM227B
Modification date2020031320200313
UniProtAcc.

Q96M60

Ensembl transtripts involved in fusion geneENST00000337018, ENST00000452918, 
ENST00000456085, ENST00000600377, 
ENST00000601879, ENST00000598202, 
ENST00000558594, ENST00000560246, 
ENST00000558862, ENST00000299338, 
ENST00000561064, 
Fusion gene scores* DoF score9 X 9 X 5=4053 X 3 X 2=18
# samples 103
** MAII scorelog2(10/405*10)=-2.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SUGP2 [Title/Abstract] AND FAM227B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSUGP2(19119126)-FAM227B(49869042), # samples:1
Anticipated loss of major functional domain due to fusion event.SUGP2-FAM227B seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SUGP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FAM227B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-B7-5818-01ASUGP2chr19

19119126

-FAM227Bchr15

49869042

-


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Fusion Gene ORF analysis for SUGP2-FAM227B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000337018ENST00000558594SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
5CDS-3UTRENST00000337018ENST00000560246SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
5CDS-3UTRENST00000452918ENST00000558594SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
5CDS-3UTRENST00000452918ENST00000560246SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
5CDS-3UTRENST00000456085ENST00000558594SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
5CDS-3UTRENST00000456085ENST00000560246SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
5CDS-3UTRENST00000600377ENST00000558594SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
5CDS-3UTRENST00000600377ENST00000560246SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
5CDS-3UTRENST00000601879ENST00000558594SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
5CDS-3UTRENST00000601879ENST00000560246SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
5CDS-intronENST00000337018ENST00000558862SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
5CDS-intronENST00000452918ENST00000558862SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
5CDS-intronENST00000456085ENST00000558862SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
5CDS-intronENST00000600377ENST00000558862SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
5CDS-intronENST00000601879ENST00000558862SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
Frame-shiftENST00000337018ENST00000299338SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
Frame-shiftENST00000337018ENST00000561064SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
Frame-shiftENST00000452918ENST00000299338SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
Frame-shiftENST00000452918ENST00000561064SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
Frame-shiftENST00000600377ENST00000299338SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
Frame-shiftENST00000600377ENST00000561064SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
In-frameENST00000456085ENST00000299338SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
In-frameENST00000456085ENST00000561064SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
In-frameENST00000601879ENST00000299338SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
In-frameENST00000601879ENST00000561064SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
intron-3CDSENST00000598202ENST00000299338SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
intron-3CDSENST00000598202ENST00000561064SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
intron-3UTRENST00000598202ENST00000558594SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
intron-3UTRENST00000598202ENST00000560246SUGP2chr19

19119126

-FAM227Bchr15

49869042

-
intron-intronENST00000598202ENST00000558862SUGP2chr19

19119126

-FAM227Bchr15

49869042

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000601879SUGP2chr1919119126-ENST00000299338FAM227Bchr1549869042-401127481332835900
ENST00000601879SUGP2chr1919119126-ENST00000561064FAM227Bchr1549869042-353227481332835900
ENST00000456085SUGP2chr1919119126-ENST00000299338FAM227Bchr1549869042-327420112542098614
ENST00000456085SUGP2chr1919119126-ENST00000561064FAM227Bchr1549869042-279520112542098614

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000601879ENST00000299338SUGP2chr1919119126-FAM227Bchr1549869042-0.0015792660.9984207
ENST00000601879ENST00000561064SUGP2chr1919119126-FAM227Bchr1549869042-0.0010828290.9989172
ENST00000456085ENST00000299338SUGP2chr1919119126-FAM227Bchr1549869042-0.005023120.9949768
ENST00000456085ENST00000561064SUGP2chr1919119126-FAM227Bchr1549869042-0.0037993490.9962006

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Fusion Genomic Features for SUGP2-FAM227B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SUGP2-FAM227B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:19119126/chr15:49869042)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FAM227B

Q96M60

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSUGP2chr19:19119126chr15:49869042ENST00000337018-611738_7768161124.0Compositional biasNote=Pro/Ser-rich
HgeneSUGP2chr19:19119126chr15:49869042ENST00000452918-611738_7768161522.3333333333333Compositional biasNote=Pro/Ser-rich
HgeneSUGP2chr19:19119126chr15:49869042ENST00000601879-610738_7768161083.0Compositional biasNote=Pro/Ser-rich
HgeneSUGP2chr19:19119126chr15:49869042ENST00000337018-611590_6338161124.0RepeatNote=SURP motif 1
HgeneSUGP2chr19:19119126chr15:49869042ENST00000452918-611590_6338161522.3333333333333RepeatNote=SURP motif 1
HgeneSUGP2chr19:19119126chr15:49869042ENST00000601879-610590_6338161083.0RepeatNote=SURP motif 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSUGP2chr19:19119126chr15:49869042ENST00000337018-611869_9058161124.0Compositional biasNote=Asp/Glu-rich
HgeneSUGP2chr19:19119126chr15:49869042ENST00000452918-611869_9058161522.3333333333333Compositional biasNote=Asp/Glu-rich
HgeneSUGP2chr19:19119126chr15:49869042ENST00000601879-610869_9058161083.0Compositional biasNote=Asp/Glu-rich
HgeneSUGP2chr19:19119126chr15:49869042ENST00000337018-6111011_10578161124.0DomainG-patch
HgeneSUGP2chr19:19119126chr15:49869042ENST00000452918-6111011_10578161522.3333333333333DomainG-patch
HgeneSUGP2chr19:19119126chr15:49869042ENST00000601879-6101011_10578161083.0DomainG-patch
HgeneSUGP2chr19:19119126chr15:49869042ENST00000337018-611995_10008161124.0MotifNuclear localization signal
HgeneSUGP2chr19:19119126chr15:49869042ENST00000452918-611995_10008161522.3333333333333MotifNuclear localization signal
HgeneSUGP2chr19:19119126chr15:49869042ENST00000601879-610995_10008161083.0MotifNuclear localization signal
HgeneSUGP2chr19:19119126chr15:49869042ENST00000337018-611787_8308161124.0RepeatNote=SURP motif 2
HgeneSUGP2chr19:19119126chr15:49869042ENST00000452918-611787_8308161522.3333333333333RepeatNote=SURP motif 2
HgeneSUGP2chr19:19119126chr15:49869042ENST00000601879-610787_8308161083.0RepeatNote=SURP motif 2


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Fusion Gene Sequence for SUGP2-FAM227B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>88004_88004_1_SUGP2-FAM227B_SUGP2_chr19_19119126_ENST00000456085_FAM227B_chr15_49869042_ENST00000299338_length(transcript)=3274nt_BP=2011nt
ATTACAAGAAAAAGCCAAACGATATCACATGGATGCCAGTGGTGAGGCTGTAAGCGAAACTCTTCAGTTTAAAGCTCAAGATCTCTTAAG
GGCAGTCCCAAGATCCAGAGCAGAGATGTATGATGACGTCCACAGCGATGGCAGATACTCCCTCAGTGGATCTGTAGCTCACTCTAGAGA
TGCCGGAAGAGAAGGCCTGAGAAGTGACGTATTTCCAGGGCCTTCCTTCAGATCAAGCAACCCTTCCATCAGTGATGACAGCTACTTTCG
CAAAGAATGTGGCCGGGATCTGGAATTTTCTCACTCTGATTCTCGGGACCAGGTCATTGGCCACCGGAAATTGGGGCATTTCCGTTCTCA
GGACTGGAAATTTGCGCTCCGTGGTTCTTGGGAACAAGACTTTGGCCATCCAGTTTCTCAAGAGTCCTCTTGGTCACAGGAGTATAGTTT
TGATCCCTCTGGGGCTGGATCTGAAGAATCTTCGGCTCCCCAGAAGAAAGATGAGCTTTGACATCATAGATAAGTCTGATGTTTTTTCAA
GATTTGGGATAGAAATAATCAAATGGGCAGGATTCCACACCATAAAAGATGATATTAAATTTTCCCAACTTTTCCAGACTCTCTTTGAAC
TTGAAACAGAAACCTGTGCTAAAATGCTTGCCTCATTCAAATGTTCCTTAAAACCAGAGCACAGAGATTTTTGCTTTTTTACTATCAAAT
TTTTAAAGCACTCTGCTTTGAAAACACCCAGAGTTGATAATGAGTTTTTAAACATGCTTTTAGACAAAGGTGCTGTGAAGACCAAAAATT
GCTTTTTTGAAATCATAAAGCCTTTTGACAAGTACATAATGAGACTTCAAGACCGGCTTCTGAAGAGTGTCACACCTTTGCTTATGGCCT
GCAATGCCTACGAGCTAAGTGTCAAGATGAAGACCCTCAGTAACCCCCTGGACTTGGCTCTTGCCCTAGAAACCACCAACTCTCTCTGCC
GGAAGTCTTTGGCCCTTTTGGGACAGACATTTTCCTTGGCCTCTTCTTTCCGGCAGGAGAAAATCTTAGAAGCTGTCGGCCTGCAAGATA
TAGCTCCCTCACCTGCTGCGTTTCCAAACTTCGAAGACTCCACTTTGTTTGGGCGAGAGTACATAGACCACCTGAAGGCCTGGCTAGTCA
GCAGCGGATGTCCCCTCCAGGTTAAGAAAGCCGAACCAGAGCCGATGCGAGAGGAGGAGAAAATGATTCCTCCTACGAAACCTGAAATTC
AGGCCAAGGCTCCAAGTAGTCTGAGTGATGCTGTCCCCCAGCGAGCAGATCACAGGGTAGTGGGCACCATCGACCAGCTTGTGAAACGTG
TCATCGAAGGCAGCCTGTCTCCCAAAGAGAGAACTCTTCTCAAAGAGGACCCTGCTTACTGGTTTTTGTCTGATGAAAATAGTCTGGAGT
ATAAATATTACAAGCTGAAGTTGGCAGAAATGCAGCGGATGAGCGAGAACTTGCGAGGAGCCGACCAGAAGCCGACCTCAGCAGACTGTG
CAGTGAGGGCCATGCTGTACTCCCGGGCTGTCCGCAACCTCAAGAAGAAACTCCTTCCGTGGCAGCGGCGGGGGCTCCTCCGTGCTCAAG
GGCTCCGGGGCTGGAAGGCGAGGAGAGCGACCACCGGGACCCAGACCCTCCTATCCTCAGGCACCAGGCTGAAACACCACGGCCGGCAGG
CTCCAGGCCTCTCACAGGCAAAACCATCCCTGCCAGACAGAAATGATGCTGCCAAGGACTGCCCGCCAGACCCAGTTGGACCTTCTCCTC
AGGACCCCAGCTTAGAAGCCTCAGGCCCATCCCCCAAGCCAGCAGGAGTGGACATCTCTGAAGCACCTCAGACCTCTTCTCCCTGCCCAT
CTGCTGACATTGACATGAAGACAATGGAGACTGCAGAGAAACTGGCTAGATTTGTTGCTCAGGTGGGACCAGAGATCGAACAATTCAGCA
TAGAAAACAGCACCGATAACCCTGACCTGTGGGTTGCAGCTTCACAGGATTCAAAGCAAATGAACTTACTCAGCTACCCAGACATTTGGA
TGCTGAACAAATTTATCTTTTTATTTTAAAAGCCCATAATTTTGATGAAAGAGTTTTTAAAATCTGGAAGACTCATTTTCTCTCAGAAGC
CTCCATTGCTCTTTTGCATGACTCCTTTTGGTGGTGGTTTCTCCATAAATTTAGGCCTGACAGAGAAAACCAAGATTGCTTATTCGATAG
AATTTCAGAAAGTTATGTGACACTTTTCATGAGCATACCTCTAAGTCGAAAGGATGCATTTTTTCAGATATATCCTGATTGTTTGGCACA
AGCCATATATGCAACGTTCCATGAAGCATTTCCAGAATCGAGTTACCTCTTTAATGATGAATTTAAAGAAGATCTAGGGAATAACATTTT
TCTTTGGTGTTCAGGTTTAAAACCTCAAAAAGGCTTTTGGATCCACTGGAAACTGAAAGAACTCTCCACAACCACCATTCATGGTAGCAA
AAAAGCACCTGCAAAATCAGTAAAGGAAAGAATTGCAGACAGTCAAGAACATATATCAACTAGTATCGACTTCAATATTATAAAGATTCT
GAACAACCCAAGAGCATATACGTTGCCCATATCCAAGGAAGAATCAAGATTATCAAGACTAGCAACAAAGTCGCACTATAGTAGTACTGG
TCCAGAGTTTAATCGTGTTCTCTTCAATTTTGGAGGTCAGAGTCCATTGATTTTATATTATCTTAAGATGCATGAGCTGGCTGGTATTTC
CAAAGCACCTAAGAAAACCAAGATTAAACTCACTAAGATATTCCAGGAACCACTACCTGCTCCAACATACCGTGATGTTATAAAGGAGGC
AAAAAGACAATTTGCAAGGAACCAAAAGGATTTTAGGATACTCCAAGCAAAGGCTACCAAGAAACCTCATGAAGTGAAACAGGACTTTGA
GAAGTTCCTACATAAACTGCGTTCCGAAGCTGAAATTGAGAGAGAATGTGTGGCATCACTATCGTCATCATCATCATCATCACCATCATC
AACAGACAACTACAACTTTGAGGAAGAAGAATACTAAGAGAAACCAGAAATGAACTCTATTCAAGAATAATGCATACAATTCAGTGGTAT
CAGTTTAATTGTAACAATATATTTAATTCAAGTCCAATCCATGTAATCAGTATTAAGAGTGTGTTTTACCATTCATCTTTAAAATCTTCA

>88004_88004_1_SUGP2-FAM227B_SUGP2_chr19_19119126_ENST00000456085_FAM227B_chr15_49869042_ENST00000299338_length(amino acids)=614AA_BP=586
MTATFAKNVAGIWNFLTLILGTRSLATGNWGISVLRTGNLRSVVLGNKTLAIQFLKSPLGHRSIVLIPLGLDLKNLRLPRRKMSFDIIDK
SDVFSRFGIEIIKWAGFHTIKDDIKFSQLFQTLFELETETCAKMLASFKCSLKPEHRDFCFFTIKFLKHSALKTPRVDNEFLNMLLDKGA
VKTKNCFFEIIKPFDKYIMRLQDRLLKSVTPLLMACNAYELSVKMKTLSNPLDLALALETTNSLCRKSLALLGQTFSLASSFRQEKILEA
VGLQDIAPSPAAFPNFEDSTLFGREYIDHLKAWLVSSGCPLQVKKAEPEPMREEEKMIPPTKPEIQAKAPSSLSDAVPQRADHRVVGTID
QLVKRVIEGSLSPKERTLLKEDPAYWFLSDENSLEYKYYKLKLAEMQRMSENLRGADQKPTSADCAVRAMLYSRAVRNLKKKLLPWQRRG
LLRAQGLRGWKARRATTGTQTLLSSGTRLKHHGRQAPGLSQAKPSLPDRNDAAKDCPPDPVGPSPQDPSLEASGPSPKPAGVDISEAPQT

--------------------------------------------------------------
>88004_88004_2_SUGP2-FAM227B_SUGP2_chr19_19119126_ENST00000456085_FAM227B_chr15_49869042_ENST00000561064_length(transcript)=2795nt_BP=2011nt
ATTACAAGAAAAAGCCAAACGATATCACATGGATGCCAGTGGTGAGGCTGTAAGCGAAACTCTTCAGTTTAAAGCTCAAGATCTCTTAAG
GGCAGTCCCAAGATCCAGAGCAGAGATGTATGATGACGTCCACAGCGATGGCAGATACTCCCTCAGTGGATCTGTAGCTCACTCTAGAGA
TGCCGGAAGAGAAGGCCTGAGAAGTGACGTATTTCCAGGGCCTTCCTTCAGATCAAGCAACCCTTCCATCAGTGATGACAGCTACTTTCG
CAAAGAATGTGGCCGGGATCTGGAATTTTCTCACTCTGATTCTCGGGACCAGGTCATTGGCCACCGGAAATTGGGGCATTTCCGTTCTCA
GGACTGGAAATTTGCGCTCCGTGGTTCTTGGGAACAAGACTTTGGCCATCCAGTTTCTCAAGAGTCCTCTTGGTCACAGGAGTATAGTTT
TGATCCCTCTGGGGCTGGATCTGAAGAATCTTCGGCTCCCCAGAAGAAAGATGAGCTTTGACATCATAGATAAGTCTGATGTTTTTTCAA
GATTTGGGATAGAAATAATCAAATGGGCAGGATTCCACACCATAAAAGATGATATTAAATTTTCCCAACTTTTCCAGACTCTCTTTGAAC
TTGAAACAGAAACCTGTGCTAAAATGCTTGCCTCATTCAAATGTTCCTTAAAACCAGAGCACAGAGATTTTTGCTTTTTTACTATCAAAT
TTTTAAAGCACTCTGCTTTGAAAACACCCAGAGTTGATAATGAGTTTTTAAACATGCTTTTAGACAAAGGTGCTGTGAAGACCAAAAATT
GCTTTTTTGAAATCATAAAGCCTTTTGACAAGTACATAATGAGACTTCAAGACCGGCTTCTGAAGAGTGTCACACCTTTGCTTATGGCCT
GCAATGCCTACGAGCTAAGTGTCAAGATGAAGACCCTCAGTAACCCCCTGGACTTGGCTCTTGCCCTAGAAACCACCAACTCTCTCTGCC
GGAAGTCTTTGGCCCTTTTGGGACAGACATTTTCCTTGGCCTCTTCTTTCCGGCAGGAGAAAATCTTAGAAGCTGTCGGCCTGCAAGATA
TAGCTCCCTCACCTGCTGCGTTTCCAAACTTCGAAGACTCCACTTTGTTTGGGCGAGAGTACATAGACCACCTGAAGGCCTGGCTAGTCA
GCAGCGGATGTCCCCTCCAGGTTAAGAAAGCCGAACCAGAGCCGATGCGAGAGGAGGAGAAAATGATTCCTCCTACGAAACCTGAAATTC
AGGCCAAGGCTCCAAGTAGTCTGAGTGATGCTGTCCCCCAGCGAGCAGATCACAGGGTAGTGGGCACCATCGACCAGCTTGTGAAACGTG
TCATCGAAGGCAGCCTGTCTCCCAAAGAGAGAACTCTTCTCAAAGAGGACCCTGCTTACTGGTTTTTGTCTGATGAAAATAGTCTGGAGT
ATAAATATTACAAGCTGAAGTTGGCAGAAATGCAGCGGATGAGCGAGAACTTGCGAGGAGCCGACCAGAAGCCGACCTCAGCAGACTGTG
CAGTGAGGGCCATGCTGTACTCCCGGGCTGTCCGCAACCTCAAGAAGAAACTCCTTCCGTGGCAGCGGCGGGGGCTCCTCCGTGCTCAAG
GGCTCCGGGGCTGGAAGGCGAGGAGAGCGACCACCGGGACCCAGACCCTCCTATCCTCAGGCACCAGGCTGAAACACCACGGCCGGCAGG
CTCCAGGCCTCTCACAGGCAAAACCATCCCTGCCAGACAGAAATGATGCTGCCAAGGACTGCCCGCCAGACCCAGTTGGACCTTCTCCTC
AGGACCCCAGCTTAGAAGCCTCAGGCCCATCCCCCAAGCCAGCAGGAGTGGACATCTCTGAAGCACCTCAGACCTCTTCTCCCTGCCCAT
CTGCTGACATTGACATGAAGACAATGGAGACTGCAGAGAAACTGGCTAGATTTGTTGCTCAGGTGGGACCAGAGATCGAACAATTCAGCA
TAGAAAACAGCACCGATAACCCTGACCTGTGGGTTGCAGCTTCACAGGATTCAAAGCAAATGAACTTACTCAGCTACCCAGACATTTGGA
TGCTGAACAAATTTATCTTTTTATTTTAAAAGCCCATAATTTTGATGAAAGAGTTTTTAAAATCTGGAAGACTCATTTTCTCTCAGAAGC
CTCCATTGCTCTTTTGCATGACTCCTTTTGGTGGTGGTTTCTCCATAAATTTAGGATATATCCTGATTGTTTGGCACAAGCCATATATGC
AACGTTCCATGAAGCATTTCCAGAATCGAGTTACCTCTTTAATGATGAATTTAAAGAAGATCTAGGGAATAACATTTTTCTTTGGTGTTC
AGGTTTAAAACCTCAAAAAGGCTTTTGGATCCACTGGAAACTGAAAGAACTCTCCACAACCACCATTCATGGTAGCAAAAAAGCACCTGC
AAAATCAGTAAAGGAAAGAATTGCAGACAGTCAAGAACATATATCAACTAGCTGAAAGTGAGAAGATCTAGATTCTTATTTGTGTTGGAC
CACTAATGACCAGTATGACTTCGGGCAAGTTACCTGCTGTTCCAGAGTCTCAGCTGCTACATTTGTAAAATTGGTGTATTGGTCTAATGC
CTCTATGGTGCTTTACAATTCTGTGATCTGTGACTTATACTCACTACTAATATAAGGAACAGGGCACCTACTTTTAAAAGCTGTTATTCT
TTAAAAAGGAGGAAATGGTTTCACATTGATTATCAGTGTTTGATTTTTGCCTCAATAAGAATATTGGAACAATAAATGTTAATTTAGAGA

>88004_88004_2_SUGP2-FAM227B_SUGP2_chr19_19119126_ENST00000456085_FAM227B_chr15_49869042_ENST00000561064_length(amino acids)=614AA_BP=586
MTATFAKNVAGIWNFLTLILGTRSLATGNWGISVLRTGNLRSVVLGNKTLAIQFLKSPLGHRSIVLIPLGLDLKNLRLPRRKMSFDIIDK
SDVFSRFGIEIIKWAGFHTIKDDIKFSQLFQTLFELETETCAKMLASFKCSLKPEHRDFCFFTIKFLKHSALKTPRVDNEFLNMLLDKGA
VKTKNCFFEIIKPFDKYIMRLQDRLLKSVTPLLMACNAYELSVKMKTLSNPLDLALALETTNSLCRKSLALLGQTFSLASSFRQEKILEA
VGLQDIAPSPAAFPNFEDSTLFGREYIDHLKAWLVSSGCPLQVKKAEPEPMREEEKMIPPTKPEIQAKAPSSLSDAVPQRADHRVVGTID
QLVKRVIEGSLSPKERTLLKEDPAYWFLSDENSLEYKYYKLKLAEMQRMSENLRGADQKPTSADCAVRAMLYSRAVRNLKKKLLPWQRRG
LLRAQGLRGWKARRATTGTQTLLSSGTRLKHHGRQAPGLSQAKPSLPDRNDAAKDCPPDPVGPSPQDPSLEASGPSPKPAGVDISEAPQT

--------------------------------------------------------------
>88004_88004_3_SUGP2-FAM227B_SUGP2_chr19_19119126_ENST00000601879_FAM227B_chr15_49869042_ENST00000299338_length(transcript)=4011nt_BP=2748nt
AACCACGTACCCGAGGGTCGCGCCAGCCCGACCCTGCGGCACCCCCACTCCCCACTCCGCGCGGGACAGGCCTCGGCAGCCGCAGCGTCT
CACCCGGTCTTCGCGGCCACGTGGGGAAAGGTGGGGCGCGCGGTTGTCACCCAGGGAGCCGCCTCTAGCCCCTTCCGGCCGCCGTACGCG
CGCAGGCGCTGTGGCGCCCCTAGGCTTGGCCTCCCAGAGACTCGCGGACGCTCACGATAACCAAGGACGACCGCGAACCAAGTGTATTTT
TTTCTCTCTCACCATAGGGCAAAATAACATGGCAGCCAGACGAATTACACAGGAGACTTTTGATGCTGTATTACAAGAAAAAGCCAAACG
ATATCACATGGATGCCAGTGGTGAGGCTGTAAGCGAAACTCTTCAGTTTAAAGCTCAAGATCTCTTAAGGGCAGTCCCAAGATCCAGAGC
AGAGATGTATGATGACGTCCACAGCGATGGCAGATACTCCCTCAGTGGATCTGTAGCTCACTCTAGAGATGCCGGAAGAGAAGGCCTGAG
AAGTGACGTATTTCCAGGGCCTTCCTTCAGATCAAGCAACCCTTCCATCAGTGATGACAGCTACTTTCGCAAAGAATGTGGCCGGGATCT
GGAATTTTCTCACTCTGATTCTCGGGACCAGGTCATTGGCCACCGGAAATTGGGGCATTTCCGTTCTCAGGACTGGAAATTTGCGCTCCG
TGGTTCTTGGGAACAAGACTTTGGCCATCCAGTTTCTCAAGAGTCCTCTTGGTCACAGGAGTATAGTTTTGGTCCCTCTGCAGTTTTGGG
GGACTTTGGATCTTCCAGGCTGATTGAGAAAGAGTGTTTGGAGAAGGAGAGTCGGGATTATGACGTGGACCATCCTGGGGAGGCTGACTC
TGTGCTTAGGGGCGGCAGTCAAGTCCAGGCCAGAGGTCGAGCTCTAAACATCGTTGACCAGGAAGGTTCCCTCCTAGGAAAGGGGGAGAC
TCAGGGCCTGCTCACAGCTAAGGGGGGTGTTGGGAAACTTGTCACATTGAGAAATGTGAGCACAAAAAAAATACCCACCGTGAATCGTAT
TACTCCCAAAACTCAGGGCACTAACCAAATCCAGAAAAACACTCCAAGTCCTGATGTGACCCTGGGGACAAACCCAGGGACAGAAGATAT
CCAGTTCCCCATTCAGAAGATCCCTCTGGGGCTGGATCTGAAGAATCTTCGGCTCCCCAGAAGAAAGATGAGCTTTGACATCATAGATAA
GTCTGATGTTTTTTCAAGATTTGGGATAGAAATAATCAAATGGGCAGGATTCCACACCATAAAAGATGATATTAAATTTTCCCAACTTTT
CCAGACTCTCTTTGAACTTGAAACAGAAACCTGTGCTAAAATGCTTGCCTCATTCAAATGTTCCTTAAAACCAGAGCACAGAGATTTTTG
CTTTTTTACTATCAAATTTTTAAAGCACTCTGCTTTGAAAACACCCAGAGTTGATAATGAGTTTTTAAACATGCTTTTAGACAAAGGTGC
TGTGAAGACCAAAAATTGCTTTTTTGAAATCATAAAGCCTTTTGACAAGTACATAATGAGACTTCAAGACCGGCTTCTGAAGAGTGTCAC
ACCTTTGCTTATGGCCTGCAATGCCTACGAGCTAAGTGTCAAGATGAAGACCCTCAGTAACCCCCTGGACTTGGCTCTTGCCCTAGAAAC
CACCAACTCTCTCTGCCGGAAGTCTTTGGCCCTTTTGGGACAGACATTTTCCTTGGCCTCTTCTTTCCGGCAGGAGAAAATCTTAGAAGC
TGTCGGCCTGCAAGATATAGCTCCCTCACCTGCTGCGTTTCCAAACTTCGAAGACTCCACTTTGTTTGGGCGAGAGTACATAGACCACCT
GAAGGCCTGGCTAGTCAGCAGCGGATGTCCCCTCCAGGTTAAGAAAGCCGAACCAGAGCCGATGCGAGAGGAGGAGAAAATGATTCCTCC
TACGAAACCTGAAATTCAGGCCAAGGCTCCAAGTAGTCTGAGTGATGCTGTCCCCCAGCGAGCAGATCACAGGGTAGTGGGCACCATCGA
CCAGCTTGTGAAACGTGTCATCGAAGGCAGCCTGTCTCCCAAAGAGAGAACTCTTCTCAAAGAGGACCCTGCTTACTGGTTTTTGTCTGA
TGAAAATAGTCTGGAGTATAAATATTACAAGCTGAAGTTGGCAGAAATGCAGCGGATGAGCGAGAACTTGCGAGGAGCCGACCAGAAGCC
GACCTCAGCAGACTGTGCAGTGAGGGCCATGCTGTACTCCCGGGCTGTCCGCAACCTCAAGAAGAAACTCCTTCCGTGGCAGCGGCGGGG
GCTCCTCCGTGCTCAAGGGCTCCGGGGCTGGAAGGCGAGGAGAGCGACCACCGGGACCCAGACCCTCCTATCCTCAGGCACCAGGCTGAA
ACACCACGGCCGGCAGGCTCCAGGCCTCTCACAGGCAAAACCATCCCTGCCAGACAGAAATGATGCTGCCAAGGACTGCCCGCCAGACCC
AGTTGGACCTTCTCCTCAGGACCCCAGCTTAGAAGCCTCAGGCCCATCCCCCAAGCCAGCAGGAGTGGACATCTCTGAAGCACCTCAGAC
CTCTTCTCCCTGCCCATCTGCTGACATTGACATGAAGACAATGGAGACTGCAGAGAAACTGGCTAGATTTGTTGCTCAGGTGGGACCAGA
GATCGAACAATTCAGCATAGAAAACAGCACCGATAACCCTGACCTGTGGGTTGCAGCTTCACAGGATTCAAAGCAAATGAACTTACTCAG
CTACCCAGACATTTGGATGCTGAACAAATTTATCTTTTTATTTTAAAAGCCCATAATTTTGATGAAAGAGTTTTTAAAATCTGGAAGACT
CATTTTCTCTCAGAAGCCTCCATTGCTCTTTTGCATGACTCCTTTTGGTGGTGGTTTCTCCATAAATTTAGGCCTGACAGAGAAAACCAA
GATTGCTTATTCGATAGAATTTCAGAAAGTTATGTGACACTTTTCATGAGCATACCTCTAAGTCGAAAGGATGCATTTTTTCAGATATAT
CCTGATTGTTTGGCACAAGCCATATATGCAACGTTCCATGAAGCATTTCCAGAATCGAGTTACCTCTTTAATGATGAATTTAAAGAAGAT
CTAGGGAATAACATTTTTCTTTGGTGTTCAGGTTTAAAACCTCAAAAAGGCTTTTGGATCCACTGGAAACTGAAAGAACTCTCCACAACC
ACCATTCATGGTAGCAAAAAAGCACCTGCAAAATCAGTAAAGGAAAGAATTGCAGACAGTCAAGAACATATATCAACTAGTATCGACTTC
AATATTATAAAGATTCTGAACAACCCAAGAGCATATACGTTGCCCATATCCAAGGAAGAATCAAGATTATCAAGACTAGCAACAAAGTCG
CACTATAGTAGTACTGGTCCAGAGTTTAATCGTGTTCTCTTCAATTTTGGAGGTCAGAGTCCATTGATTTTATATTATCTTAAGATGCAT
GAGCTGGCTGGTATTTCCAAAGCACCTAAGAAAACCAAGATTAAACTCACTAAGATATTCCAGGAACCACTACCTGCTCCAACATACCGT
GATGTTATAAAGGAGGCAAAAAGACAATTTGCAAGGAACCAAAAGGATTTTAGGATACTCCAAGCAAAGGCTACCAAGAAACCTCATGAA
GTGAAACAGGACTTTGAGAAGTTCCTACATAAACTGCGTTCCGAAGCTGAAATTGAGAGAGAATGTGTGGCATCACTATCGTCATCATCA
TCATCATCACCATCATCAACAGACAACTACAACTTTGAGGAAGAAGAATACTAAGAGAAACCAGAAATGAACTCTATTCAAGAATAATGC
ATACAATTCAGTGGTATCAGTTTAATTGTAACAATATATTTAATTCAAGTCCAATCCATGTAATCAGTATTAAGAGTGTGTTTTACCATT

>88004_88004_3_SUGP2-FAM227B_SUGP2_chr19_19119126_ENST00000601879_FAM227B_chr15_49869042_ENST00000299338_length(amino acids)=900AA_BP=872
MSPREPPLAPSGRRTRAGAVAPLGLASQRLADAHDNQGRPRTKCIFFSLTIGQNNMAARRITQETFDAVLQEKAKRYHMDASGEAVSETL
QFKAQDLLRAVPRSRAEMYDDVHSDGRYSLSGSVAHSRDAGREGLRSDVFPGPSFRSSNPSISDDSYFRKECGRDLEFSHSDSRDQVIGH
RKLGHFRSQDWKFALRGSWEQDFGHPVSQESSWSQEYSFGPSAVLGDFGSSRLIEKECLEKESRDYDVDHPGEADSVLRGGSQVQARGRA
LNIVDQEGSLLGKGETQGLLTAKGGVGKLVTLRNVSTKKIPTVNRITPKTQGTNQIQKNTPSPDVTLGTNPGTEDIQFPIQKIPLGLDLK
NLRLPRRKMSFDIIDKSDVFSRFGIEIIKWAGFHTIKDDIKFSQLFQTLFELETETCAKMLASFKCSLKPEHRDFCFFTIKFLKHSALKT
PRVDNEFLNMLLDKGAVKTKNCFFEIIKPFDKYIMRLQDRLLKSVTPLLMACNAYELSVKMKTLSNPLDLALALETTNSLCRKSLALLGQ
TFSLASSFRQEKILEAVGLQDIAPSPAAFPNFEDSTLFGREYIDHLKAWLVSSGCPLQVKKAEPEPMREEEKMIPPTKPEIQAKAPSSLS
DAVPQRADHRVVGTIDQLVKRVIEGSLSPKERTLLKEDPAYWFLSDENSLEYKYYKLKLAEMQRMSENLRGADQKPTSADCAVRAMLYSR
AVRNLKKKLLPWQRRGLLRAQGLRGWKARRATTGTQTLLSSGTRLKHHGRQAPGLSQAKPSLPDRNDAAKDCPPDPVGPSPQDPSLEASG
PSPKPAGVDISEAPQTSSPCPSADIDMKTMETAEKLARFVAQVGPEIEQFSIENSTDNPDLWVAASQDSKQMNLLSYPDIWMLNKFIFLF

--------------------------------------------------------------
>88004_88004_4_SUGP2-FAM227B_SUGP2_chr19_19119126_ENST00000601879_FAM227B_chr15_49869042_ENST00000561064_length(transcript)=3532nt_BP=2748nt
AACCACGTACCCGAGGGTCGCGCCAGCCCGACCCTGCGGCACCCCCACTCCCCACTCCGCGCGGGACAGGCCTCGGCAGCCGCAGCGTCT
CACCCGGTCTTCGCGGCCACGTGGGGAAAGGTGGGGCGCGCGGTTGTCACCCAGGGAGCCGCCTCTAGCCCCTTCCGGCCGCCGTACGCG
CGCAGGCGCTGTGGCGCCCCTAGGCTTGGCCTCCCAGAGACTCGCGGACGCTCACGATAACCAAGGACGACCGCGAACCAAGTGTATTTT
TTTCTCTCTCACCATAGGGCAAAATAACATGGCAGCCAGACGAATTACACAGGAGACTTTTGATGCTGTATTACAAGAAAAAGCCAAACG
ATATCACATGGATGCCAGTGGTGAGGCTGTAAGCGAAACTCTTCAGTTTAAAGCTCAAGATCTCTTAAGGGCAGTCCCAAGATCCAGAGC
AGAGATGTATGATGACGTCCACAGCGATGGCAGATACTCCCTCAGTGGATCTGTAGCTCACTCTAGAGATGCCGGAAGAGAAGGCCTGAG
AAGTGACGTATTTCCAGGGCCTTCCTTCAGATCAAGCAACCCTTCCATCAGTGATGACAGCTACTTTCGCAAAGAATGTGGCCGGGATCT
GGAATTTTCTCACTCTGATTCTCGGGACCAGGTCATTGGCCACCGGAAATTGGGGCATTTCCGTTCTCAGGACTGGAAATTTGCGCTCCG
TGGTTCTTGGGAACAAGACTTTGGCCATCCAGTTTCTCAAGAGTCCTCTTGGTCACAGGAGTATAGTTTTGGTCCCTCTGCAGTTTTGGG
GGACTTTGGATCTTCCAGGCTGATTGAGAAAGAGTGTTTGGAGAAGGAGAGTCGGGATTATGACGTGGACCATCCTGGGGAGGCTGACTC
TGTGCTTAGGGGCGGCAGTCAAGTCCAGGCCAGAGGTCGAGCTCTAAACATCGTTGACCAGGAAGGTTCCCTCCTAGGAAAGGGGGAGAC
TCAGGGCCTGCTCACAGCTAAGGGGGGTGTTGGGAAACTTGTCACATTGAGAAATGTGAGCACAAAAAAAATACCCACCGTGAATCGTAT
TACTCCCAAAACTCAGGGCACTAACCAAATCCAGAAAAACACTCCAAGTCCTGATGTGACCCTGGGGACAAACCCAGGGACAGAAGATAT
CCAGTTCCCCATTCAGAAGATCCCTCTGGGGCTGGATCTGAAGAATCTTCGGCTCCCCAGAAGAAAGATGAGCTTTGACATCATAGATAA
GTCTGATGTTTTTTCAAGATTTGGGATAGAAATAATCAAATGGGCAGGATTCCACACCATAAAAGATGATATTAAATTTTCCCAACTTTT
CCAGACTCTCTTTGAACTTGAAACAGAAACCTGTGCTAAAATGCTTGCCTCATTCAAATGTTCCTTAAAACCAGAGCACAGAGATTTTTG
CTTTTTTACTATCAAATTTTTAAAGCACTCTGCTTTGAAAACACCCAGAGTTGATAATGAGTTTTTAAACATGCTTTTAGACAAAGGTGC
TGTGAAGACCAAAAATTGCTTTTTTGAAATCATAAAGCCTTTTGACAAGTACATAATGAGACTTCAAGACCGGCTTCTGAAGAGTGTCAC
ACCTTTGCTTATGGCCTGCAATGCCTACGAGCTAAGTGTCAAGATGAAGACCCTCAGTAACCCCCTGGACTTGGCTCTTGCCCTAGAAAC
CACCAACTCTCTCTGCCGGAAGTCTTTGGCCCTTTTGGGACAGACATTTTCCTTGGCCTCTTCTTTCCGGCAGGAGAAAATCTTAGAAGC
TGTCGGCCTGCAAGATATAGCTCCCTCACCTGCTGCGTTTCCAAACTTCGAAGACTCCACTTTGTTTGGGCGAGAGTACATAGACCACCT
GAAGGCCTGGCTAGTCAGCAGCGGATGTCCCCTCCAGGTTAAGAAAGCCGAACCAGAGCCGATGCGAGAGGAGGAGAAAATGATTCCTCC
TACGAAACCTGAAATTCAGGCCAAGGCTCCAAGTAGTCTGAGTGATGCTGTCCCCCAGCGAGCAGATCACAGGGTAGTGGGCACCATCGA
CCAGCTTGTGAAACGTGTCATCGAAGGCAGCCTGTCTCCCAAAGAGAGAACTCTTCTCAAAGAGGACCCTGCTTACTGGTTTTTGTCTGA
TGAAAATAGTCTGGAGTATAAATATTACAAGCTGAAGTTGGCAGAAATGCAGCGGATGAGCGAGAACTTGCGAGGAGCCGACCAGAAGCC
GACCTCAGCAGACTGTGCAGTGAGGGCCATGCTGTACTCCCGGGCTGTCCGCAACCTCAAGAAGAAACTCCTTCCGTGGCAGCGGCGGGG
GCTCCTCCGTGCTCAAGGGCTCCGGGGCTGGAAGGCGAGGAGAGCGACCACCGGGACCCAGACCCTCCTATCCTCAGGCACCAGGCTGAA
ACACCACGGCCGGCAGGCTCCAGGCCTCTCACAGGCAAAACCATCCCTGCCAGACAGAAATGATGCTGCCAAGGACTGCCCGCCAGACCC
AGTTGGACCTTCTCCTCAGGACCCCAGCTTAGAAGCCTCAGGCCCATCCCCCAAGCCAGCAGGAGTGGACATCTCTGAAGCACCTCAGAC
CTCTTCTCCCTGCCCATCTGCTGACATTGACATGAAGACAATGGAGACTGCAGAGAAACTGGCTAGATTTGTTGCTCAGGTGGGACCAGA
GATCGAACAATTCAGCATAGAAAACAGCACCGATAACCCTGACCTGTGGGTTGCAGCTTCACAGGATTCAAAGCAAATGAACTTACTCAG
CTACCCAGACATTTGGATGCTGAACAAATTTATCTTTTTATTTTAAAAGCCCATAATTTTGATGAAAGAGTTTTTAAAATCTGGAAGACT
CATTTTCTCTCAGAAGCCTCCATTGCTCTTTTGCATGACTCCTTTTGGTGGTGGTTTCTCCATAAATTTAGGATATATCCTGATTGTTTG
GCACAAGCCATATATGCAACGTTCCATGAAGCATTTCCAGAATCGAGTTACCTCTTTAATGATGAATTTAAAGAAGATCTAGGGAATAAC
ATTTTTCTTTGGTGTTCAGGTTTAAAACCTCAAAAAGGCTTTTGGATCCACTGGAAACTGAAAGAACTCTCCACAACCACCATTCATGGT
AGCAAAAAAGCACCTGCAAAATCAGTAAAGGAAAGAATTGCAGACAGTCAAGAACATATATCAACTAGCTGAAAGTGAGAAGATCTAGAT
TCTTATTTGTGTTGGACCACTAATGACCAGTATGACTTCGGGCAAGTTACCTGCTGTTCCAGAGTCTCAGCTGCTACATTTGTAAAATTG
GTGTATTGGTCTAATGCCTCTATGGTGCTTTACAATTCTGTGATCTGTGACTTATACTCACTACTAATATAAGGAACAGGGCACCTACTT
TTAAAAGCTGTTATTCTTTAAAAAGGAGGAAATGGTTTCACATTGATTATCAGTGTTTGATTTTTGCCTCAATAAGAATATTGGAACAAT

>88004_88004_4_SUGP2-FAM227B_SUGP2_chr19_19119126_ENST00000601879_FAM227B_chr15_49869042_ENST00000561064_length(amino acids)=900AA_BP=872
MSPREPPLAPSGRRTRAGAVAPLGLASQRLADAHDNQGRPRTKCIFFSLTIGQNNMAARRITQETFDAVLQEKAKRYHMDASGEAVSETL
QFKAQDLLRAVPRSRAEMYDDVHSDGRYSLSGSVAHSRDAGREGLRSDVFPGPSFRSSNPSISDDSYFRKECGRDLEFSHSDSRDQVIGH
RKLGHFRSQDWKFALRGSWEQDFGHPVSQESSWSQEYSFGPSAVLGDFGSSRLIEKECLEKESRDYDVDHPGEADSVLRGGSQVQARGRA
LNIVDQEGSLLGKGETQGLLTAKGGVGKLVTLRNVSTKKIPTVNRITPKTQGTNQIQKNTPSPDVTLGTNPGTEDIQFPIQKIPLGLDLK
NLRLPRRKMSFDIIDKSDVFSRFGIEIIKWAGFHTIKDDIKFSQLFQTLFELETETCAKMLASFKCSLKPEHRDFCFFTIKFLKHSALKT
PRVDNEFLNMLLDKGAVKTKNCFFEIIKPFDKYIMRLQDRLLKSVTPLLMACNAYELSVKMKTLSNPLDLALALETTNSLCRKSLALLGQ
TFSLASSFRQEKILEAVGLQDIAPSPAAFPNFEDSTLFGREYIDHLKAWLVSSGCPLQVKKAEPEPMREEEKMIPPTKPEIQAKAPSSLS
DAVPQRADHRVVGTIDQLVKRVIEGSLSPKERTLLKEDPAYWFLSDENSLEYKYYKLKLAEMQRMSENLRGADQKPTSADCAVRAMLYSR
AVRNLKKKLLPWQRRGLLRAQGLRGWKARRATTGTQTLLSSGTRLKHHGRQAPGLSQAKPSLPDRNDAAKDCPPDPVGPSPQDPSLEASG
PSPKPAGVDISEAPQTSSPCPSADIDMKTMETAEKLARFVAQVGPEIEQFSIENSTDNPDLWVAASQDSKQMNLLSYPDIWMLNKFIFLF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SUGP2-FAM227B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SUGP2-FAM227B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SUGP2-FAM227B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource