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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SULF2-PHF20 (FusionGDB2 ID:88045)

Fusion Gene Summary for SULF2-PHF20

check button Fusion gene summary
Fusion gene informationFusion gene name: SULF2-PHF20
Fusion gene ID: 88045
HgeneTgene
Gene symbol

SULF2

PHF20

Gene ID

55959

51230

Gene namesulfatase 2PHD finger protein 20
SynonymsHSULF-2C20orf104|GLEA2|HCA58|NZF|TDRD20A|TZP
Cytomap

20q13.12

20q11.22-q11.23

Type of geneprotein-codingprotein-coding
Descriptionextracellular sulfatase Sulf-2PHD finger protein 20glioma-expressed antigen 2hepatocellular carcinoma-associated antigen 58novel zinc finger proteintranscription factor TZPtudor domain containing 20A
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000359930, ENST00000361612, 
ENST00000467815, ENST00000484875, 
ENST00000478766, 		ENST00000439301, 
ENST00000481202, ENST00000374012, 
Fusion gene scores* DoF score12 X 13 X 7=109226 X 25 X 15=9750
# samples 1432
** MAII scorelog2(14/1092*10)=-2.96347412397489
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(32/9750*10)=-4.92925840863697
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SULF2 [Title/Abstract] AND PHF20 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSULF2(46331262)-PHF20(34515701), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSULF2

GO:0030177

positive regulation of Wnt signaling pathway

19520866

HgeneSULF2

GO:0030201

heparan sulfate proteoglycan metabolic process

18687675

TgenePHF20

GO:0043981

histone H4-K5 acetylation

20018852

TgenePHF20

GO:0043982

histone H4-K8 acetylation

20018852

TgenePHF20

GO:0043984

histone H4-K16 acetylation

20018852


check buttonFusion gene breakpoints across SULF2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PHF20 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-7178SULF2chr20

46331262

-PHF20chr20

34515701

+


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Fusion Gene ORF analysis for SULF2-PHF20

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000359930ENST00000439301SULF2chr20

46331262

-PHF20chr20

34515701

+
5CDS-3UTRENST00000361612ENST00000439301SULF2chr20

46331262

-PHF20chr20

34515701

+
5CDS-3UTRENST00000467815ENST00000439301SULF2chr20

46331262

-PHF20chr20

34515701

+
5CDS-3UTRENST00000484875ENST00000439301SULF2chr20

46331262

-PHF20chr20

34515701

+
5CDS-intronENST00000359930ENST00000481202SULF2chr20

46331262

-PHF20chr20

34515701

+
5CDS-intronENST00000361612ENST00000481202SULF2chr20

46331262

-PHF20chr20

34515701

+
5CDS-intronENST00000467815ENST00000481202SULF2chr20

46331262

-PHF20chr20

34515701

+
5CDS-intronENST00000484875ENST00000481202SULF2chr20

46331262

-PHF20chr20

34515701

+
In-frameENST00000359930ENST00000374012SULF2chr20

46331262

-PHF20chr20

34515701

+
In-frameENST00000361612ENST00000374012SULF2chr20

46331262

-PHF20chr20

34515701

+
In-frameENST00000467815ENST00000374012SULF2chr20

46331262

-PHF20chr20

34515701

+
In-frameENST00000484875ENST00000374012SULF2chr20

46331262

-PHF20chr20

34515701

+
intron-3CDSENST00000478766ENST00000374012SULF2chr20

46331262

-PHF20chr20

34515701

+
intron-3UTRENST00000478766ENST00000439301SULF2chr20

46331262

-PHF20chr20

34515701

+
intron-intronENST00000478766ENST00000481202SULF2chr20

46331262

-PHF20chr20

34515701

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000359930SULF2chr2046331262-ENST00000374012PHF20chr2034515701+520814198522453533
ENST00000484875SULF2chr2046331262-ENST00000374012PHF20chr2034515701+502512366692270533
ENST00000361612SULF2chr2046331262-ENST00000374012PHF20chr2034515701+502512366692270533
ENST00000467815SULF2chr2046331262-ENST00000374012PHF20chr2034515701+496311746072208533

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000359930ENST00000374012SULF2chr2046331262-PHF20chr2034515701+0.0030666150.99693334
ENST00000484875ENST00000374012SULF2chr2046331262-PHF20chr2034515701+0.0031859890.9968141
ENST00000361612ENST00000374012SULF2chr2046331262-PHF20chr2034515701+0.0031859890.9968141
ENST00000467815ENST00000374012SULF2chr2046331262-PHF20chr2034515701+0.0031679150.9968321

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Fusion Genomic Features for SULF2-PHF20


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SULF2chr2046331262-PHF20chr2034515701+0.0059846090.9940154
SULF2chr2046331262-PHF20chr2034515701+0.0059846090.9940154

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SULF2-PHF20


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:46331262/chr20:34515701)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePHF20chr20:46331262chr20:34515701ENST000004393011319654_7006461356.0Zinc fingerNote=PHD-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePHF20chr20:46331262chr20:34515701ENST000003740121218162_2216681013.0Compositional biasNote=Lys-rich
TgenePHF20chr20:46331262chr20:34515701ENST000003740121218523_5526681013.0Compositional biasNote=Lys-rich
TgenePHF20chr20:46331262chr20:34515701ENST000004393011319162_2216461356.0Compositional biasNote=Lys-rich
TgenePHF20chr20:46331262chr20:34515701ENST000004393011319523_5526461356.0Compositional biasNote=Lys-rich
TgenePHF20chr20:46331262chr20:34515701ENST000003740121218257_2696681013.0DNA bindingNote=A.T hook
TgenePHF20chr20:46331262chr20:34515701ENST000004393011319257_2696461356.0DNA bindingNote=A.T hook
TgenePHF20chr20:46331262chr20:34515701ENST0000037401212184_696681013.0DomainNote=Tudor 1
TgenePHF20chr20:46331262chr20:34515701ENST00000374012121883_1476681013.0DomainNote=Tudor 2
TgenePHF20chr20:46331262chr20:34515701ENST0000043930113194_696461356.0DomainNote=Tudor 1
TgenePHF20chr20:46331262chr20:34515701ENST00000439301131983_1476461356.0DomainNote=Tudor 2
TgenePHF20chr20:46331262chr20:34515701ENST000003740121218452_4776681013.0Zinc fingerC2H2-type
TgenePHF20chr20:46331262chr20:34515701ENST000003740121218654_7006681013.0Zinc fingerNote=PHD-type
TgenePHF20chr20:46331262chr20:34515701ENST000004393011319452_4776461356.0Zinc fingerC2H2-type


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Fusion Gene Sequence for SULF2-PHF20


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>88045_88045_1_SULF2-PHF20_SULF2_chr20_46331262_ENST00000359930_PHF20_chr20_34515701_ENST00000374012_length(transcript)=5208nt_BP=1419nt
CACTTGAGCCGAAGTTAATTTCTCGGGGAGTTCTCGGGCGCGCACAGGCAGCTCGGTTTGCCCTGCGATTGAGCTGCGGGTCGCGGCCGG
CGCCGGCCTCTCCAATGGCAAATGTGTGTGGCTGGAGGCGAGCGCGAGGCTTTCGGCAAAGGCAGTCGAGTGTTTGCAGACCGGGGCGAG
TCCTGTGAAAGCAGATAAAAGAAAACATTTATTAACGTGTCATTACGAGGGGAGCGCCCGGCCGGGGCTGTCGCACTCCCCGCGGAACAT
TTGGCTCCCTCCAGCTCCGAGAGAGGAGAAGAAGAAAGCGGAAAAGAGGCAGATTCACGTCGTTTCCAGCCAAGTGGACCTGATCGATGG
CCCTCCTGAATTTATCACGATATTTGATTTATTAGCGATGCCCCCTGGTTTGTGTGTTACGCACACACACGTGCACACAAGGCTCTGGCT
CGCTTCCCTCCCTCGTTTCCAGCTCCTGGGCGAATCCCACATCTGTTTCAACTCTCCGCCGAGGGCGAGCAGGAGCGAGAGTGTGTCGAG
TGAGTGTGCGTCTGTGTGTCCCGGCGAGGGTGCGCGCTCGGCGCCGGGAGCGCGGCCAGCCGAGTCCGGAGGCATCGGGAGGTCGAGAGC
CGCCGGGACCCCAGCTCTGCGTTCACTGCCCCGTCCGGAGCTGGACTTCGGGGCCGGGGCCGGGGCCGTGCGCCGGGGACAGGCAGGGCC
GGGTCGCGGGCCGCGCGTCCCCCAGGCCGGAGATCTGCGAGTGAAGAGGGACGAGGGAAAAGAAACAAAGCCACAGACGCAACTTGAGAC
TCCCGCATCCCAAAAGAAGCACCAGATCAGCAAAAAAAGAAGATGGGCCCCCCGAGCCTCGTGCTGTGCTTGCTGTCCGCAACTGTGTTC
TCCCTGCTGGGTGGAAGCTCGGCCTTCCTGTCGCACCACCGCCTGAAAGGCAGGTTTCAGAGGGACCGCAGGAACATCCGCCCCAACATC
ATCCTGGTGCTGACGGACGACCAGGATGTGGAGCTGGGTTCCATGCAGGTGATGAACAAGACCCGGCGCATCATGGAGCAGGGCGGGGCG
CACTTCATCAACGCCTTCGTGACCACACCCATGTGCTGCCCCTCACGCTCCTCCATCCTCACTGGCAAGTACGTCCACAACCACAACACC
TACACCAACAATGAGAACTGCTCCTCGCCCTCCTGGCAGGCACAGCACGAGAGCCGCACCTTTGCCGTGTACCTCAATAGCACTGGCTAC
CGGACAGCTTTCTTCGGGAAGTATCTTAATGAATACAACGGCTCCTACGTGCCACCCGGCTGGAAGGAGTGGGTCGGACTCCTTAAAAAC
TCCCGCTTTTATAACTACACGCTGTGTCGGAACGGGGTGAAAGAGAAGCACGGCTCCGACTACTCCAAGTGTGAAGAGTGCCAGTGCTGG
CAGCATGGGGTCTGCATGGGATTACTGGAAGAAAATGTGCCCGAGAAATACACCTGTTATGTTTGCCAAGACCCTCCAGGTCAGAGGCCT
GGCTTCAAGTACTGGTATGACAAGGAGTGGCTGAGCAGGGGACATATGCATGGCCTGGCATTTCTAGAAGAGAACTACTCCCATCAGAAT
GCCAAGAAGATCGTGGCCACCCACCAGCTTCTTGGTGATGTGCAGAGAGTGATTGAGGTTCTGCATGGCCTGCAGCTCAAGATGAGCATC
TTGCAAAGCCGGGAGCATCCTGATCTGCCGCTGTGGTGCCAGCCTTGGAAACAGCACTCAGGGGAGGGGAGATCTCATTTCAGAAACATC
CCTGTCACTGACACCAGGAGCAAGGAGGAAGCTCCAAGCTATAGAACTTTGAACGGGGCAGTGGAGAAGCCCAGGCCCCTGGCCCTGCCC
CTGCCGCGTTCTGTGGAGGAATCCTATATCACCAGTGAGCATTGCTACCAGAAGCCCCGCGCCTATTACCCTGCCGTGGAGCAGAAGCTG
GTGGTGGAGACGAGGGGCTCTGCCCTCGACGATGCGGTCAACCCCCTCCATGAGAACGGCGATGATTCCCTTTCCCCGCGCCTGGGCTGG
CCTCTAGACCAAGACAGGAGCAAGGGGGACAGTGACCCCAAACCCGGCTCCCCAAAGGTGAAGGAATATGTCTCCAAAAAGGCCCTACCA
GAAGAAGCCCCTGCTCGGAAGCTGCTGGACAGAGGTGGAGAGGGGCTGCTGAGCTCCCAGCACCAGTGGCAGTTTAACCTGCTGACCCAT
GTGGAATCTCTTCAGGATGAAGTTACGCACAGGATGGACTCCATTGAGAAGGAGTTGGATGTGTTGGAGAGCTGGCTGGACTACACTGGG
GAACTGGAGCCCCCTGAGCCGCTGGCCAGGCTTCCGCAGCTCAAGCATTGTATCAAGCAGCTGCTGATGGACCTGGGCAAGGTGCAGCAG
ATCGCCCTCTGCTGCTCAACATGAAACTGGGCACCCAAAACTCATGGGGGCACAATCCTGGGGCACCTGCAGGAGGAGCTTCGCATATTT
AAATAAATAAACCTAGCATGCTGAATGCACGTGACACCGACTGACTTCAGGGATCTGGGCCAGGAGTGTGGTGGACATTGGACAAAGAGG
CCATTTTGGCTGCGGGAGGACACTCTGATCTCGAAGCCTGCCATAAAGGTAGCAAATAGACTCTTGGGATTCCCCTCTTCTGTGCACATC
GTTGAATGAAGAGAGTCTTTTTGCACAAACTTCACTTGAAATTGTGCCACTGATGATAAACGGAATGAGAGCCAAAAAAGTTTAGTTGGA
GACAGTTGTAAATTCAATTTGGAGTTTATTTAATTGACTTTTCTATCACGTTGGGGCACATGCCAACTCCCTGGTTTCTTCCTGGCATGG
TGTTTGGGCAGCAGGCATCATTTTCCTTTTCTAGCTTCATAGGAATATTGTGAGCTCACCATGCTGTGGAGGTTGGGAAAGAGCAGAGTC
TTGGCTGCCCTGCTTTCTCCTTAGGACTCTTCACTTTTCTCACCACATCTCTTGCATGACTTCATGGTACTGGGGACAAGTTTGTATGCC
TTCACCCCAGAGCTGGCTGGGTTATGGCTTTTGTAGCAGAGCCCATACAGCCTATGGAAGAACTAGAATCTCACTCACAGTAATAAGAAT
CTAGGAGGAATTCCAAACCGAAGCAGGCAGGGTCTGGAACCCAAAGGACAGCATTTTCTACCCACTTCTTAATATTGACAGCTTCCCCGT
TCTATTTAATGTCCAAAAATGTTTCCCAAAATTTCAAACTCTTTCACTGTAAAGATTTGTTACAAAGAATGTGGTTTGGGGAATTACCTT
ATTTTATATTGTTGTAAACAAACTTCAAATTCTACATGTGCGACTTTTCTCCTTCCTGAAGGGTGTTTAGTAGTCAGCGTTTTCAGAATT
GTTTTGTTACTATACTTTAACATTTTACATTTCCTGTTTGTATTATTTTGTGAGAGCAAGGTGATCATGCTGCTTAAGGTCCAGGTACAA
CCTATTTGTACCTTTTGAGACAATATTTGTGTTACTTTTGCAGGTTACGGTTCCACATGTAATTGCTATATTTTGTTTTGTTTTTCCTTA
CTAGGCAAAGTTAAAATGTTCCATGCTTTGAGGAGTGACCCATTTCACTACTTTGTTTTCTTATCACTAAAGGCAAAAATCAAAGCACAG
TTGTCCATTAACACTTATAAGTTAATTATGGGTTTATGAGTCTGTAATGTTATATGCTGCAAACATTTACTATGTAAACGTGAAGTAGCC
AATAATATCTCAATAGTAGTAACAGTATCTTTAGCGACCTTTGGAATAGTTAAGCACAGGTCATTGTGGACATGAATTCAGGCCTCTGTA
CTAAAATCTATTTCAGGGAATGTTCTGTCTAGTGATTTGCTCACCATTTGATATATAATGAATTATAGGACAAGTATAAGCTGATCTGCT
ATAGCTGTCCATCAGAGAGAATACACGTGGCTATAACATCTATAACAAAACGACGATTCCTCTACAAGAGGCTGTTTCTCACTGCTAACG
TTGGTGTTTCTGGCGTGGGAAGAAATGCACAGGCGTGCATGGCATGCACGTTCAGACAGCTGCATTGTAAGAGTTCTGTCATGCAGTCTG
AAAAGGGAAGAAACAGGATGGCTTTCTGTAGCCACACCTGTGAGGCGTGATGATTGTTGTATTATTAGATTACTGATTTTTCTTTTCTGA
AAATACATTTGAGTTTTAATCACATCTGTGGAAGCTGTAACTTTTAAGGTAGTCAATTTCATGTCTTGTTCAACGATGTAAGCAGAAACT
GAATTGCCCTAATTTTGCCAACTGGCCATTATTGGGATTATTGTTTAAATTTTTGGTAAAGGAAGTAATCTCCTTTCATTCATTGTGACT
TTTGTTCTTAGGGAAGCAGAGAAGACTCCCCAAGTTCTTATAACCTCATTGTGCTTCCCTAATTTAAAGCCATGTTGAGGGGCTCCATTC
CCAATTCCTGGGTCAAGGTGAATTAACCCTATGTTGGAGCACTGGAAACCGTTATTTGCAAACATTGCTGTTACCATTTAGAAATATGTG
CACTATCAGCTGGGTGCAGTGGCTCACGTCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCGAG
ACCAGCCTGGCCAACAGGGTGAAACCCCGTCTCTACTAAAAGTACAAAAATTAGCTGGGCGTGGTGGCGGACGCCTGTAATCTCAGCTAC
TTGGGAGGCTGAAGCAGGAGAGGTGCTGGAACCTGGGAGGCGGAGGTTGAAGTGAGCCGAGATTGCGCTATTGCACTCCAGCTCGGGCGA
CAACTGCAAGACTCCATCTCAAAAAAATAAAAATAAAAGAAAAGAAAGAAATATGTGCACTACCTAAGTTTTGTCTTTAGAAAAACTATC
CACCTATAAAAAATTACCTTGACAAAAATAGTTCCGGTTTGACTAATCATTTTGTTTCTTTAAGTGGTAAGTGTATGCAAGGTGGATCCT
TGATGAGCCAACATTGCACTGTGGATACATATCTATGTTTACGCGCTATTAGAACAGAAGGCGCTGTATATAGAAATGTTGCTTTGAAGC

>88045_88045_1_SULF2-PHF20_SULF2_chr20_46331262_ENST00000359930_PHF20_chr20_34515701_ENST00000374012_length(amino acids)=533AA_BP=189
MGPPSLVLCLLSATVFSLLGGSSAFLSHHRLKGRFQRDRRNIRPNIILVLTDDQDVELGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCP
SRSSILTGKYVHNHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKYLNEYNGSYVPPGWKEWVGLLKNSRFYNYTLCRNGVK
EKHGSDYSKCEECQCWQHGVCMGLLEENVPEKYTCYVCQDPPGQRPGFKYWYDKEWLSRGHMHGLAFLEENYSHQNAKKIVATHQLLGDV
QRVIEVLHGLQLKMSILQSREHPDLPLWCQPWKQHSGEGRSHFRNIPVTDTRSKEEAPSYRTLNGAVEKPRPLALPLPRSVEESYITSEH
CYQKPRAYYPAVEQKLVVETRGSALDDAVNPLHENGDDSLSPRLGWPLDQDRSKGDSDPKPGSPKVKEYVSKKALPEEAPARKLLDRGGE

--------------------------------------------------------------
>88045_88045_2_SULF2-PHF20_SULF2_chr20_46331262_ENST00000361612_PHF20_chr20_34515701_ENST00000374012_length(transcript)=5025nt_BP=1236nt
GGGCCATTTCTGGACAACAGCTGCTATTTTCACTTGAGCCGAAGTTAATTTCTCGGGGAGTTCTCGGGCGCGCACAGGCAGCTCGGTTTG
CCCTGCGATTGAGCTGCGGGTCGCGGCCGGCGCCGGCCTCTCCAATGGCAAATGTGTGTGGCTGGAGGCGAGCGCGAGGCTTTCGGCAAA
GGCAGTCGAGTGTTTGCAGACCGGGGCGAGTCCTGTGAAAGCAGATAAAAGAAAACATTTATTAACGTGTCATTACGAGGGGAGCGCCCG
GCCGGGGCTGTCGCACTCCCCGCGGAACATTTGGCTCCCTCCAGCTCCGAGAGAGGAGAAGAAGAAAGCGGAAAAGAGGCAGATTCACGT
CGTTTCCAGCCAAGTGGACCTGATCGATGGCCCTCCTGAATTTATCACGATATTTGATTTATTAGCGATGCCCCCTGGTTTGTGTGTTAC
GCACACACACGTGCACACAAGGCTCTGGCTCGCTTCCCTCCCTCGTTTCCAGCTCCTGGGCGAATCCCACATCTGTTTCAACTCTCCGCC
GAGGGCGAGCAGGAGCGAGAGTGTGTCGAATCTGCGAGTGAAGAGGGACGAGGGAAAAGAAACAAAGCCACAGACGCAACTTGAGACTCC
CGCATCCCAAAAGAAGCACCAGATCAGCAAAAAAAGAAGATGGGCCCCCCGAGCCTCGTGCTGTGCTTGCTGTCCGCAACTGTGTTCTCC
CTGCTGGGTGGAAGCTCGGCCTTCCTGTCGCACCACCGCCTGAAAGGCAGGTTTCAGAGGGACCGCAGGAACATCCGCCCCAACATCATC
CTGGTGCTGACGGACGACCAGGATGTGGAGCTGGGTTCCATGCAGGTGATGAACAAGACCCGGCGCATCATGGAGCAGGGCGGGGCGCAC
TTCATCAACGCCTTCGTGACCACACCCATGTGCTGCCCCTCACGCTCCTCCATCCTCACTGGCAAGTACGTCCACAACCACAACACCTAC
ACCAACAATGAGAACTGCTCCTCGCCCTCCTGGCAGGCACAGCACGAGAGCCGCACCTTTGCCGTGTACCTCAATAGCACTGGCTACCGG
ACAGCTTTCTTCGGGAAGTATCTTAATGAATACAACGGCTCCTACGTGCCACCCGGCTGGAAGGAGTGGGTCGGACTCCTTAAAAACTCC
CGCTTTTATAACTACACGCTGTGTCGGAACGGGGTGAAAGAGAAGCACGGCTCCGACTACTCCAAGTGTGAAGAGTGCCAGTGCTGGCAG
CATGGGGTCTGCATGGGATTACTGGAAGAAAATGTGCCCGAGAAATACACCTGTTATGTTTGCCAAGACCCTCCAGGTCAGAGGCCTGGC
TTCAAGTACTGGTATGACAAGGAGTGGCTGAGCAGGGGACATATGCATGGCCTGGCATTTCTAGAAGAGAACTACTCCCATCAGAATGCC
AAGAAGATCGTGGCCACCCACCAGCTTCTTGGTGATGTGCAGAGAGTGATTGAGGTTCTGCATGGCCTGCAGCTCAAGATGAGCATCTTG
CAAAGCCGGGAGCATCCTGATCTGCCGCTGTGGTGCCAGCCTTGGAAACAGCACTCAGGGGAGGGGAGATCTCATTTCAGAAACATCCCT
GTCACTGACACCAGGAGCAAGGAGGAAGCTCCAAGCTATAGAACTTTGAACGGGGCAGTGGAGAAGCCCAGGCCCCTGGCCCTGCCCCTG
CCGCGTTCTGTGGAGGAATCCTATATCACCAGTGAGCATTGCTACCAGAAGCCCCGCGCCTATTACCCTGCCGTGGAGCAGAAGCTGGTG
GTGGAGACGAGGGGCTCTGCCCTCGACGATGCGGTCAACCCCCTCCATGAGAACGGCGATGATTCCCTTTCCCCGCGCCTGGGCTGGCCT
CTAGACCAAGACAGGAGCAAGGGGGACAGTGACCCCAAACCCGGCTCCCCAAAGGTGAAGGAATATGTCTCCAAAAAGGCCCTACCAGAA
GAAGCCCCTGCTCGGAAGCTGCTGGACAGAGGTGGAGAGGGGCTGCTGAGCTCCCAGCACCAGTGGCAGTTTAACCTGCTGACCCATGTG
GAATCTCTTCAGGATGAAGTTACGCACAGGATGGACTCCATTGAGAAGGAGTTGGATGTGTTGGAGAGCTGGCTGGACTACACTGGGGAA
CTGGAGCCCCCTGAGCCGCTGGCCAGGCTTCCGCAGCTCAAGCATTGTATCAAGCAGCTGCTGATGGACCTGGGCAAGGTGCAGCAGATC
GCCCTCTGCTGCTCAACATGAAACTGGGCACCCAAAACTCATGGGGGCACAATCCTGGGGCACCTGCAGGAGGAGCTTCGCATATTTAAA
TAAATAAACCTAGCATGCTGAATGCACGTGACACCGACTGACTTCAGGGATCTGGGCCAGGAGTGTGGTGGACATTGGACAAAGAGGCCA
TTTTGGCTGCGGGAGGACACTCTGATCTCGAAGCCTGCCATAAAGGTAGCAAATAGACTCTTGGGATTCCCCTCTTCTGTGCACATCGTT
GAATGAAGAGAGTCTTTTTGCACAAACTTCACTTGAAATTGTGCCACTGATGATAAACGGAATGAGAGCCAAAAAAGTTTAGTTGGAGAC
AGTTGTAAATTCAATTTGGAGTTTATTTAATTGACTTTTCTATCACGTTGGGGCACATGCCAACTCCCTGGTTTCTTCCTGGCATGGTGT
TTGGGCAGCAGGCATCATTTTCCTTTTCTAGCTTCATAGGAATATTGTGAGCTCACCATGCTGTGGAGGTTGGGAAAGAGCAGAGTCTTG
GCTGCCCTGCTTTCTCCTTAGGACTCTTCACTTTTCTCACCACATCTCTTGCATGACTTCATGGTACTGGGGACAAGTTTGTATGCCTTC
ACCCCAGAGCTGGCTGGGTTATGGCTTTTGTAGCAGAGCCCATACAGCCTATGGAAGAACTAGAATCTCACTCACAGTAATAAGAATCTA
GGAGGAATTCCAAACCGAAGCAGGCAGGGTCTGGAACCCAAAGGACAGCATTTTCTACCCACTTCTTAATATTGACAGCTTCCCCGTTCT
ATTTAATGTCCAAAAATGTTTCCCAAAATTTCAAACTCTTTCACTGTAAAGATTTGTTACAAAGAATGTGGTTTGGGGAATTACCTTATT
TTATATTGTTGTAAACAAACTTCAAATTCTACATGTGCGACTTTTCTCCTTCCTGAAGGGTGTTTAGTAGTCAGCGTTTTCAGAATTGTT
TTGTTACTATACTTTAACATTTTACATTTCCTGTTTGTATTATTTTGTGAGAGCAAGGTGATCATGCTGCTTAAGGTCCAGGTACAACCT
ATTTGTACCTTTTGAGACAATATTTGTGTTACTTTTGCAGGTTACGGTTCCACATGTAATTGCTATATTTTGTTTTGTTTTTCCTTACTA
GGCAAAGTTAAAATGTTCCATGCTTTGAGGAGTGACCCATTTCACTACTTTGTTTTCTTATCACTAAAGGCAAAAATCAAAGCACAGTTG
TCCATTAACACTTATAAGTTAATTATGGGTTTATGAGTCTGTAATGTTATATGCTGCAAACATTTACTATGTAAACGTGAAGTAGCCAAT
AATATCTCAATAGTAGTAACAGTATCTTTAGCGACCTTTGGAATAGTTAAGCACAGGTCATTGTGGACATGAATTCAGGCCTCTGTACTA
AAATCTATTTCAGGGAATGTTCTGTCTAGTGATTTGCTCACCATTTGATATATAATGAATTATAGGACAAGTATAAGCTGATCTGCTATA
GCTGTCCATCAGAGAGAATACACGTGGCTATAACATCTATAACAAAACGACGATTCCTCTACAAGAGGCTGTTTCTCACTGCTAACGTTG
GTGTTTCTGGCGTGGGAAGAAATGCACAGGCGTGCATGGCATGCACGTTCAGACAGCTGCATTGTAAGAGTTCTGTCATGCAGTCTGAAA
AGGGAAGAAACAGGATGGCTTTCTGTAGCCACACCTGTGAGGCGTGATGATTGTTGTATTATTAGATTACTGATTTTTCTTTTCTGAAAA
TACATTTGAGTTTTAATCACATCTGTGGAAGCTGTAACTTTTAAGGTAGTCAATTTCATGTCTTGTTCAACGATGTAAGCAGAAACTGAA
TTGCCCTAATTTTGCCAACTGGCCATTATTGGGATTATTGTTTAAATTTTTGGTAAAGGAAGTAATCTCCTTTCATTCATTGTGACTTTT
GTTCTTAGGGAAGCAGAGAAGACTCCCCAAGTTCTTATAACCTCATTGTGCTTCCCTAATTTAAAGCCATGTTGAGGGGCTCCATTCCCA
ATTCCTGGGTCAAGGTGAATTAACCCTATGTTGGAGCACTGGAAACCGTTATTTGCAAACATTGCTGTTACCATTTAGAAATATGTGCAC
TATCAGCTGGGTGCAGTGGCTCACGTCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCGAGACC
AGCCTGGCCAACAGGGTGAAACCCCGTCTCTACTAAAAGTACAAAAATTAGCTGGGCGTGGTGGCGGACGCCTGTAATCTCAGCTACTTG
GGAGGCTGAAGCAGGAGAGGTGCTGGAACCTGGGAGGCGGAGGTTGAAGTGAGCCGAGATTGCGCTATTGCACTCCAGCTCGGGCGACAA
CTGCAAGACTCCATCTCAAAAAAATAAAAATAAAAGAAAAGAAAGAAATATGTGCACTACCTAAGTTTTGTCTTTAGAAAAACTATCCAC
CTATAAAAAATTACCTTGACAAAAATAGTTCCGGTTTGACTAATCATTTTGTTTCTTTAAGTGGTAAGTGTATGCAAGGTGGATCCTTGA
TGAGCCAACATTGCACTGTGGATACATATCTATGTTTACGCGCTATTAGAACAGAAGGCGCTGTATATAGAAATGTTGCTTTGAAGCAAT

>88045_88045_2_SULF2-PHF20_SULF2_chr20_46331262_ENST00000361612_PHF20_chr20_34515701_ENST00000374012_length(amino acids)=533AA_BP=189
MGPPSLVLCLLSATVFSLLGGSSAFLSHHRLKGRFQRDRRNIRPNIILVLTDDQDVELGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCP
SRSSILTGKYVHNHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKYLNEYNGSYVPPGWKEWVGLLKNSRFYNYTLCRNGVK
EKHGSDYSKCEECQCWQHGVCMGLLEENVPEKYTCYVCQDPPGQRPGFKYWYDKEWLSRGHMHGLAFLEENYSHQNAKKIVATHQLLGDV
QRVIEVLHGLQLKMSILQSREHPDLPLWCQPWKQHSGEGRSHFRNIPVTDTRSKEEAPSYRTLNGAVEKPRPLALPLPRSVEESYITSEH
CYQKPRAYYPAVEQKLVVETRGSALDDAVNPLHENGDDSLSPRLGWPLDQDRSKGDSDPKPGSPKVKEYVSKKALPEEAPARKLLDRGGE

--------------------------------------------------------------
>88045_88045_3_SULF2-PHF20_SULF2_chr20_46331262_ENST00000467815_PHF20_chr20_34515701_ENST00000374012_length(transcript)=4963nt_BP=1174nt
CTCGGGCGCGCACAGGCAGCTCGGTTTGCCCTGCGATTGAGCTGCGGGTCGCGGCCGGCGCCGGCCTCTCCAATGGCAAATGTGTGTGGC
TGGAGGCGAGCGCGAGGCTTTCGGCAAAGGCAGTCGAGTGTTTGCAGACCGGGGCGAGTCCTGTGAAAGCAGATAAAAGAAAACATTTAT
TAACGTGTCATTACGAGGGGAGCGCCCGGCCGGGGCTGTCGCACTCCCCGCGGAACATTTGGCTCCCTCCAGCTCCGAGAGAGGAGAAGA
AGAAAGCGGAAAAGAGGCAGATTCACGTCGTTTCCAGCCAAGTGGACCTGATCGATGGCCCTCCTGAATTTATCACGATATTTGATTTAT
TAGCGATGCCCCCTGGTTTGTGTGTTACGCACACACACGTGCACACAAGGCTCTGGCTCGCTTCCCTCCCTCGTTTCCAGCTCCTGGGCG
AATCCCACATCTGTTTCAACTCTCCGCCGAGGGCGAGCAGGAGCGAGAGTGTGTCGAATCTGCGAGTGAAGAGGGACGAGGGAAAAGAAA
CAAAGCCACAGACGCAACTTGAGACTCCCGCATCCCAAAAGAAGCACCAGATCAGCAAAAAAAGAAGATGGGCCCCCCGAGCCTCGTGCT
GTGCTTGCTGTCCGCAACTGTGTTCTCCCTGCTGGGTGGAAGCTCGGCCTTCCTGTCGCACCACCGCCTGAAAGGCAGGTTTCAGAGGGA
CCGCAGGAACATCCGCCCCAACATCATCCTGGTGCTGACGGACGACCAGGATGTGGAGCTGGGTTCCATGCAGGTGATGAACAAGACCCG
GCGCATCATGGAGCAGGGCGGGGCGCACTTCATCAACGCCTTCGTGACCACACCCATGTGCTGCCCCTCACGCTCCTCCATCCTCACTGG
CAAGTACGTCCACAACCACAACACCTACACCAACAATGAGAACTGCTCCTCGCCCTCCTGGCAGGCACAGCACGAGAGCCGCACCTTTGC
CGTGTACCTCAATAGCACTGGCTACCGGACAGCTTTCTTCGGGAAGTATCTTAATGAATACAACGGCTCCTACGTGCCACCCGGCTGGAA
GGAGTGGGTCGGACTCCTTAAAAACTCCCGCTTTTATAACTACACGCTGTGTCGGAACGGGGTGAAAGAGAAGCACGGCTCCGACTACTC
CAAGTGTGAAGAGTGCCAGTGCTGGCAGCATGGGGTCTGCATGGGATTACTGGAAGAAAATGTGCCCGAGAAATACACCTGTTATGTTTG
CCAAGACCCTCCAGGTCAGAGGCCTGGCTTCAAGTACTGGTATGACAAGGAGTGGCTGAGCAGGGGACATATGCATGGCCTGGCATTTCT
AGAAGAGAACTACTCCCATCAGAATGCCAAGAAGATCGTGGCCACCCACCAGCTTCTTGGTGATGTGCAGAGAGTGATTGAGGTTCTGCA
TGGCCTGCAGCTCAAGATGAGCATCTTGCAAAGCCGGGAGCATCCTGATCTGCCGCTGTGGTGCCAGCCTTGGAAACAGCACTCAGGGGA
GGGGAGATCTCATTTCAGAAACATCCCTGTCACTGACACCAGGAGCAAGGAGGAAGCTCCAAGCTATAGAACTTTGAACGGGGCAGTGGA
GAAGCCCAGGCCCCTGGCCCTGCCCCTGCCGCGTTCTGTGGAGGAATCCTATATCACCAGTGAGCATTGCTACCAGAAGCCCCGCGCCTA
TTACCCTGCCGTGGAGCAGAAGCTGGTGGTGGAGACGAGGGGCTCTGCCCTCGACGATGCGGTCAACCCCCTCCATGAGAACGGCGATGA
TTCCCTTTCCCCGCGCCTGGGCTGGCCTCTAGACCAAGACAGGAGCAAGGGGGACAGTGACCCCAAACCCGGCTCCCCAAAGGTGAAGGA
ATATGTCTCCAAAAAGGCCCTACCAGAAGAAGCCCCTGCTCGGAAGCTGCTGGACAGAGGTGGAGAGGGGCTGCTGAGCTCCCAGCACCA
GTGGCAGTTTAACCTGCTGACCCATGTGGAATCTCTTCAGGATGAAGTTACGCACAGGATGGACTCCATTGAGAAGGAGTTGGATGTGTT
GGAGAGCTGGCTGGACTACACTGGGGAACTGGAGCCCCCTGAGCCGCTGGCCAGGCTTCCGCAGCTCAAGCATTGTATCAAGCAGCTGCT
GATGGACCTGGGCAAGGTGCAGCAGATCGCCCTCTGCTGCTCAACATGAAACTGGGCACCCAAAACTCATGGGGGCACAATCCTGGGGCA
CCTGCAGGAGGAGCTTCGCATATTTAAATAAATAAACCTAGCATGCTGAATGCACGTGACACCGACTGACTTCAGGGATCTGGGCCAGGA
GTGTGGTGGACATTGGACAAAGAGGCCATTTTGGCTGCGGGAGGACACTCTGATCTCGAAGCCTGCCATAAAGGTAGCAAATAGACTCTT
GGGATTCCCCTCTTCTGTGCACATCGTTGAATGAAGAGAGTCTTTTTGCACAAACTTCACTTGAAATTGTGCCACTGATGATAAACGGAA
TGAGAGCCAAAAAAGTTTAGTTGGAGACAGTTGTAAATTCAATTTGGAGTTTATTTAATTGACTTTTCTATCACGTTGGGGCACATGCCA
ACTCCCTGGTTTCTTCCTGGCATGGTGTTTGGGCAGCAGGCATCATTTTCCTTTTCTAGCTTCATAGGAATATTGTGAGCTCACCATGCT
GTGGAGGTTGGGAAAGAGCAGAGTCTTGGCTGCCCTGCTTTCTCCTTAGGACTCTTCACTTTTCTCACCACATCTCTTGCATGACTTCAT
GGTACTGGGGACAAGTTTGTATGCCTTCACCCCAGAGCTGGCTGGGTTATGGCTTTTGTAGCAGAGCCCATACAGCCTATGGAAGAACTA
GAATCTCACTCACAGTAATAAGAATCTAGGAGGAATTCCAAACCGAAGCAGGCAGGGTCTGGAACCCAAAGGACAGCATTTTCTACCCAC
TTCTTAATATTGACAGCTTCCCCGTTCTATTTAATGTCCAAAAATGTTTCCCAAAATTTCAAACTCTTTCACTGTAAAGATTTGTTACAA
AGAATGTGGTTTGGGGAATTACCTTATTTTATATTGTTGTAAACAAACTTCAAATTCTACATGTGCGACTTTTCTCCTTCCTGAAGGGTG
TTTAGTAGTCAGCGTTTTCAGAATTGTTTTGTTACTATACTTTAACATTTTACATTTCCTGTTTGTATTATTTTGTGAGAGCAAGGTGAT
CATGCTGCTTAAGGTCCAGGTACAACCTATTTGTACCTTTTGAGACAATATTTGTGTTACTTTTGCAGGTTACGGTTCCACATGTAATTG
CTATATTTTGTTTTGTTTTTCCTTACTAGGCAAAGTTAAAATGTTCCATGCTTTGAGGAGTGACCCATTTCACTACTTTGTTTTCTTATC
ACTAAAGGCAAAAATCAAAGCACAGTTGTCCATTAACACTTATAAGTTAATTATGGGTTTATGAGTCTGTAATGTTATATGCTGCAAACA
TTTACTATGTAAACGTGAAGTAGCCAATAATATCTCAATAGTAGTAACAGTATCTTTAGCGACCTTTGGAATAGTTAAGCACAGGTCATT
GTGGACATGAATTCAGGCCTCTGTACTAAAATCTATTTCAGGGAATGTTCTGTCTAGTGATTTGCTCACCATTTGATATATAATGAATTA
TAGGACAAGTATAAGCTGATCTGCTATAGCTGTCCATCAGAGAGAATACACGTGGCTATAACATCTATAACAAAACGACGATTCCTCTAC
AAGAGGCTGTTTCTCACTGCTAACGTTGGTGTTTCTGGCGTGGGAAGAAATGCACAGGCGTGCATGGCATGCACGTTCAGACAGCTGCAT
TGTAAGAGTTCTGTCATGCAGTCTGAAAAGGGAAGAAACAGGATGGCTTTCTGTAGCCACACCTGTGAGGCGTGATGATTGTTGTATTAT
TAGATTACTGATTTTTCTTTTCTGAAAATACATTTGAGTTTTAATCACATCTGTGGAAGCTGTAACTTTTAAGGTAGTCAATTTCATGTC
TTGTTCAACGATGTAAGCAGAAACTGAATTGCCCTAATTTTGCCAACTGGCCATTATTGGGATTATTGTTTAAATTTTTGGTAAAGGAAG
TAATCTCCTTTCATTCATTGTGACTTTTGTTCTTAGGGAAGCAGAGAAGACTCCCCAAGTTCTTATAACCTCATTGTGCTTCCCTAATTT
AAAGCCATGTTGAGGGGCTCCATTCCCAATTCCTGGGTCAAGGTGAATTAACCCTATGTTGGAGCACTGGAAACCGTTATTTGCAAACAT
TGCTGTTACCATTTAGAAATATGTGCACTATCAGCTGGGTGCAGTGGCTCACGTCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTG
GATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACAGGGTGAAACCCCGTCTCTACTAAAAGTACAAAAATTAGCTGGGCGTGGT
GGCGGACGCCTGTAATCTCAGCTACTTGGGAGGCTGAAGCAGGAGAGGTGCTGGAACCTGGGAGGCGGAGGTTGAAGTGAGCCGAGATTG
CGCTATTGCACTCCAGCTCGGGCGACAACTGCAAGACTCCATCTCAAAAAAATAAAAATAAAAGAAAAGAAAGAAATATGTGCACTACCT
AAGTTTTGTCTTTAGAAAAACTATCCACCTATAAAAAATTACCTTGACAAAAATAGTTCCGGTTTGACTAATCATTTTGTTTCTTTAAGT
GGTAAGTGTATGCAAGGTGGATCCTTGATGAGCCAACATTGCACTGTGGATACATATCTATGTTTACGCGCTATTAGAACAGAAGGCGCT
GTATATAGAAATGTTGCTTTGAAGCAATATTTGCAAAACACGCAGACTTCTGTATCTGTATTTGGAAAAAATAAAACAGGTTCTTGTTGC

>88045_88045_3_SULF2-PHF20_SULF2_chr20_46331262_ENST00000467815_PHF20_chr20_34515701_ENST00000374012_length(amino acids)=533AA_BP=189
MGPPSLVLCLLSATVFSLLGGSSAFLSHHRLKGRFQRDRRNIRPNIILVLTDDQDVELGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCP
SRSSILTGKYVHNHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKYLNEYNGSYVPPGWKEWVGLLKNSRFYNYTLCRNGVK
EKHGSDYSKCEECQCWQHGVCMGLLEENVPEKYTCYVCQDPPGQRPGFKYWYDKEWLSRGHMHGLAFLEENYSHQNAKKIVATHQLLGDV
QRVIEVLHGLQLKMSILQSREHPDLPLWCQPWKQHSGEGRSHFRNIPVTDTRSKEEAPSYRTLNGAVEKPRPLALPLPRSVEESYITSEH
CYQKPRAYYPAVEQKLVVETRGSALDDAVNPLHENGDDSLSPRLGWPLDQDRSKGDSDPKPGSPKVKEYVSKKALPEEAPARKLLDRGGE

--------------------------------------------------------------
>88045_88045_4_SULF2-PHF20_SULF2_chr20_46331262_ENST00000484875_PHF20_chr20_34515701_ENST00000374012_length(transcript)=5025nt_BP=1236nt
GGGCCATTTCTGGACAACAGCTGCTATTTTCACTTGAGCCGAAGTTAATTTCTCGGGGAGTTCTCGGGCGCGCACAGGCAGCTCGGTTTG
CCCTGCGATTGAGCTGCGGGTCGCGGCCGGCGCCGGCCTCTCCAATGGCAAATGTGTGTGGCTGGAGGCGAGCGCGAGGCTTTCGGCAAA
GGCAGTCGAGTGTTTGCAGACCGGGGCGAGTCCTGTGAAAGCAGATAAAAGAAAACATTTATTAACGTGTCATTACGAGGGGAGCGCCCG
GCCGGGGCTGTCGCACTCCCCGCGGAACATTTGGCTCCCTCCAGCTCCGAGAGAGGAGAAGAAGAAAGCGGAAAAGAGGCAGATTCACGT
CGTTTCCAGCCAAGTGGACCTGATCGATGGCCCTCCTGAATTTATCACGATATTTGATTTATTAGCGATGCCCCCTGGTTTGTGTGTTAC
GCACACACACGTGCACACAAGGCTCTGGCTCGCTTCCCTCCCTCGTTTCCAGCTCCTGGGCGAATCCCACATCTGTTTCAACTCTCCGCC
GAGGGCGAGCAGGAGCGAGAGTGTGTCGAATCTGCGAGTGAAGAGGGACGAGGGAAAAGAAACAAAGCCACAGACGCAACTTGAGACTCC
CGCATCCCAAAAGAAGCACCAGATCAGCAAAAAAAGAAGATGGGCCCCCCGAGCCTCGTGCTGTGCTTGCTGTCCGCAACTGTGTTCTCC
CTGCTGGGTGGAAGCTCGGCCTTCCTGTCGCACCACCGCCTGAAAGGCAGGTTTCAGAGGGACCGCAGGAACATCCGCCCCAACATCATC
CTGGTGCTGACGGACGACCAGGATGTGGAGCTGGGTTCCATGCAGGTGATGAACAAGACCCGGCGCATCATGGAGCAGGGCGGGGCGCAC
TTCATCAACGCCTTCGTGACCACACCCATGTGCTGCCCCTCACGCTCCTCCATCCTCACTGGCAAGTACGTCCACAACCACAACACCTAC
ACCAACAATGAGAACTGCTCCTCGCCCTCCTGGCAGGCACAGCACGAGAGCCGCACCTTTGCCGTGTACCTCAATAGCACTGGCTACCGG
ACAGCTTTCTTCGGGAAGTATCTTAATGAATACAACGGCTCCTACGTGCCACCCGGCTGGAAGGAGTGGGTCGGACTCCTTAAAAACTCC
CGCTTTTATAACTACACGCTGTGTCGGAACGGGGTGAAAGAGAAGCACGGCTCCGACTACTCCAAGTGTGAAGAGTGCCAGTGCTGGCAG
CATGGGGTCTGCATGGGATTACTGGAAGAAAATGTGCCCGAGAAATACACCTGTTATGTTTGCCAAGACCCTCCAGGTCAGAGGCCTGGC
TTCAAGTACTGGTATGACAAGGAGTGGCTGAGCAGGGGACATATGCATGGCCTGGCATTTCTAGAAGAGAACTACTCCCATCAGAATGCC
AAGAAGATCGTGGCCACCCACCAGCTTCTTGGTGATGTGCAGAGAGTGATTGAGGTTCTGCATGGCCTGCAGCTCAAGATGAGCATCTTG
CAAAGCCGGGAGCATCCTGATCTGCCGCTGTGGTGCCAGCCTTGGAAACAGCACTCAGGGGAGGGGAGATCTCATTTCAGAAACATCCCT
GTCACTGACACCAGGAGCAAGGAGGAAGCTCCAAGCTATAGAACTTTGAACGGGGCAGTGGAGAAGCCCAGGCCCCTGGCCCTGCCCCTG
CCGCGTTCTGTGGAGGAATCCTATATCACCAGTGAGCATTGCTACCAGAAGCCCCGCGCCTATTACCCTGCCGTGGAGCAGAAGCTGGTG
GTGGAGACGAGGGGCTCTGCCCTCGACGATGCGGTCAACCCCCTCCATGAGAACGGCGATGATTCCCTTTCCCCGCGCCTGGGCTGGCCT
CTAGACCAAGACAGGAGCAAGGGGGACAGTGACCCCAAACCCGGCTCCCCAAAGGTGAAGGAATATGTCTCCAAAAAGGCCCTACCAGAA
GAAGCCCCTGCTCGGAAGCTGCTGGACAGAGGTGGAGAGGGGCTGCTGAGCTCCCAGCACCAGTGGCAGTTTAACCTGCTGACCCATGTG
GAATCTCTTCAGGATGAAGTTACGCACAGGATGGACTCCATTGAGAAGGAGTTGGATGTGTTGGAGAGCTGGCTGGACTACACTGGGGAA
CTGGAGCCCCCTGAGCCGCTGGCCAGGCTTCCGCAGCTCAAGCATTGTATCAAGCAGCTGCTGATGGACCTGGGCAAGGTGCAGCAGATC
GCCCTCTGCTGCTCAACATGAAACTGGGCACCCAAAACTCATGGGGGCACAATCCTGGGGCACCTGCAGGAGGAGCTTCGCATATTTAAA
TAAATAAACCTAGCATGCTGAATGCACGTGACACCGACTGACTTCAGGGATCTGGGCCAGGAGTGTGGTGGACATTGGACAAAGAGGCCA
TTTTGGCTGCGGGAGGACACTCTGATCTCGAAGCCTGCCATAAAGGTAGCAAATAGACTCTTGGGATTCCCCTCTTCTGTGCACATCGTT
GAATGAAGAGAGTCTTTTTGCACAAACTTCACTTGAAATTGTGCCACTGATGATAAACGGAATGAGAGCCAAAAAAGTTTAGTTGGAGAC
AGTTGTAAATTCAATTTGGAGTTTATTTAATTGACTTTTCTATCACGTTGGGGCACATGCCAACTCCCTGGTTTCTTCCTGGCATGGTGT
TTGGGCAGCAGGCATCATTTTCCTTTTCTAGCTTCATAGGAATATTGTGAGCTCACCATGCTGTGGAGGTTGGGAAAGAGCAGAGTCTTG
GCTGCCCTGCTTTCTCCTTAGGACTCTTCACTTTTCTCACCACATCTCTTGCATGACTTCATGGTACTGGGGACAAGTTTGTATGCCTTC
ACCCCAGAGCTGGCTGGGTTATGGCTTTTGTAGCAGAGCCCATACAGCCTATGGAAGAACTAGAATCTCACTCACAGTAATAAGAATCTA
GGAGGAATTCCAAACCGAAGCAGGCAGGGTCTGGAACCCAAAGGACAGCATTTTCTACCCACTTCTTAATATTGACAGCTTCCCCGTTCT
ATTTAATGTCCAAAAATGTTTCCCAAAATTTCAAACTCTTTCACTGTAAAGATTTGTTACAAAGAATGTGGTTTGGGGAATTACCTTATT
TTATATTGTTGTAAACAAACTTCAAATTCTACATGTGCGACTTTTCTCCTTCCTGAAGGGTGTTTAGTAGTCAGCGTTTTCAGAATTGTT
TTGTTACTATACTTTAACATTTTACATTTCCTGTTTGTATTATTTTGTGAGAGCAAGGTGATCATGCTGCTTAAGGTCCAGGTACAACCT
ATTTGTACCTTTTGAGACAATATTTGTGTTACTTTTGCAGGTTACGGTTCCACATGTAATTGCTATATTTTGTTTTGTTTTTCCTTACTA
GGCAAAGTTAAAATGTTCCATGCTTTGAGGAGTGACCCATTTCACTACTTTGTTTTCTTATCACTAAAGGCAAAAATCAAAGCACAGTTG
TCCATTAACACTTATAAGTTAATTATGGGTTTATGAGTCTGTAATGTTATATGCTGCAAACATTTACTATGTAAACGTGAAGTAGCCAAT
AATATCTCAATAGTAGTAACAGTATCTTTAGCGACCTTTGGAATAGTTAAGCACAGGTCATTGTGGACATGAATTCAGGCCTCTGTACTA
AAATCTATTTCAGGGAATGTTCTGTCTAGTGATTTGCTCACCATTTGATATATAATGAATTATAGGACAAGTATAAGCTGATCTGCTATA
GCTGTCCATCAGAGAGAATACACGTGGCTATAACATCTATAACAAAACGACGATTCCTCTACAAGAGGCTGTTTCTCACTGCTAACGTTG
GTGTTTCTGGCGTGGGAAGAAATGCACAGGCGTGCATGGCATGCACGTTCAGACAGCTGCATTGTAAGAGTTCTGTCATGCAGTCTGAAA
AGGGAAGAAACAGGATGGCTTTCTGTAGCCACACCTGTGAGGCGTGATGATTGTTGTATTATTAGATTACTGATTTTTCTTTTCTGAAAA
TACATTTGAGTTTTAATCACATCTGTGGAAGCTGTAACTTTTAAGGTAGTCAATTTCATGTCTTGTTCAACGATGTAAGCAGAAACTGAA
TTGCCCTAATTTTGCCAACTGGCCATTATTGGGATTATTGTTTAAATTTTTGGTAAAGGAAGTAATCTCCTTTCATTCATTGTGACTTTT
GTTCTTAGGGAAGCAGAGAAGACTCCCCAAGTTCTTATAACCTCATTGTGCTTCCCTAATTTAAAGCCATGTTGAGGGGCTCCATTCCCA
ATTCCTGGGTCAAGGTGAATTAACCCTATGTTGGAGCACTGGAAACCGTTATTTGCAAACATTGCTGTTACCATTTAGAAATATGTGCAC
TATCAGCTGGGTGCAGTGGCTCACGTCTGTAATCCCAGCACTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTCGAGACC
AGCCTGGCCAACAGGGTGAAACCCCGTCTCTACTAAAAGTACAAAAATTAGCTGGGCGTGGTGGCGGACGCCTGTAATCTCAGCTACTTG
GGAGGCTGAAGCAGGAGAGGTGCTGGAACCTGGGAGGCGGAGGTTGAAGTGAGCCGAGATTGCGCTATTGCACTCCAGCTCGGGCGACAA
CTGCAAGACTCCATCTCAAAAAAATAAAAATAAAAGAAAAGAAAGAAATATGTGCACTACCTAAGTTTTGTCTTTAGAAAAACTATCCAC
CTATAAAAAATTACCTTGACAAAAATAGTTCCGGTTTGACTAATCATTTTGTTTCTTTAAGTGGTAAGTGTATGCAAGGTGGATCCTTGA
TGAGCCAACATTGCACTGTGGATACATATCTATGTTTACGCGCTATTAGAACAGAAGGCGCTGTATATAGAAATGTTGCTTTGAAGCAAT

>88045_88045_4_SULF2-PHF20_SULF2_chr20_46331262_ENST00000484875_PHF20_chr20_34515701_ENST00000374012_length(amino acids)=533AA_BP=189
MGPPSLVLCLLSATVFSLLGGSSAFLSHHRLKGRFQRDRRNIRPNIILVLTDDQDVELGSMQVMNKTRRIMEQGGAHFINAFVTTPMCCP
SRSSILTGKYVHNHNTYTNNENCSSPSWQAQHESRTFAVYLNSTGYRTAFFGKYLNEYNGSYVPPGWKEWVGLLKNSRFYNYTLCRNGVK
EKHGSDYSKCEECQCWQHGVCMGLLEENVPEKYTCYVCQDPPGQRPGFKYWYDKEWLSRGHMHGLAFLEENYSHQNAKKIVATHQLLGDV
QRVIEVLHGLQLKMSILQSREHPDLPLWCQPWKQHSGEGRSHFRNIPVTDTRSKEEAPSYRTLNGAVEKPRPLALPLPRSVEESYITSEH
CYQKPRAYYPAVEQKLVVETRGSALDDAVNPLHENGDDSLSPRLGWPLDQDRSKGDSDPKPGSPKVKEYVSKKALPEEAPARKLLDRGGE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SULF2-PHF20


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SULF2-PHF20


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SULF2-PHF20


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource