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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SULT1C2-CLASP2 (FusionGDB2 ID:88059)

Fusion Gene Summary for SULT1C2-CLASP2

check button Fusion gene summary
Fusion gene informationFusion gene name: SULT1C2-CLASP2
Fusion gene ID: 88059
HgeneTgene
Gene symbol

SULT1C2

CLASP2

Gene ID

27233

23122

Gene namesulfotransferase family 1C member 4cytoplasmic linker associated protein 2
SynonymsSULT1C|SULT1C2-
Cytomap

2q12.3

3p22.3

Type of geneprotein-codingprotein-coding
Descriptionsulfotransferase 1C4ST1C4SULT1C#2sulfotransferase 1C2sulfotransferase family, cytosolic, 1C, member 2sulfotransferase family, cytosolic, 1C, member 4sulfotransferase family, cytosolic, 1C, member C2CLIP-associating protein 2CLIP-associating protein CLASP2multiple asters (Mast)-like homolog 2protein Orbit homolog 2
Modification date2020031320200313
UniProtAcc.

O75122

Ensembl transtripts involved in fusion geneENST00000251481, ENST00000326853, 
ENST00000409880, ENST00000437390, 
ENST00000492554, 		ENST00000307312, 
ENST00000359576, ENST00000461133, 
ENST00000480013, ENST00000539981, 
ENST00000313350, ENST00000333778, 
ENST00000482896, ENST00000487200, 
ENST00000399362, ENST00000468888, 
Fusion gene scores* DoF score3 X 1 X 2=615 X 10 X 9=1350
# samples 315
** MAII scorelog2(3/6*10)=2.32192809488736log2(15/1350*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SULT1C2 [Title/Abstract] AND CLASP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSULT1C2(108910810)-CLASP2(33543260), # samples:1
Anticipated loss of major functional domain due to fusion event.SULT1C2-CLASP2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSULT1C2

GO:0006068

ethanol catabolic process

23207770

HgeneSULT1C2

GO:0050427

3'-phosphoadenosine 5'-phosphosulfate metabolic process

23207770

HgeneSULT1C2

GO:0051923

sulfation

20056724|23207770


check buttonFusion gene breakpoints across SULT1C2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across CLASP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-A4Z0-01ASULT1C2chr2

108910810

+CLASP2chr3

33543260

-


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Fusion Gene ORF analysis for SULT1C2-CLASP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000251481ENST00000307312SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-3UTRENST00000251481ENST00000359576SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-3UTRENST00000251481ENST00000461133SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-3UTRENST00000251481ENST00000480013SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-3UTRENST00000251481ENST00000539981SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-3UTRENST00000326853ENST00000307312SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-3UTRENST00000326853ENST00000359576SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-3UTRENST00000326853ENST00000461133SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-3UTRENST00000326853ENST00000480013SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-3UTRENST00000326853ENST00000539981SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-3UTRENST00000409880ENST00000307312SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-3UTRENST00000409880ENST00000359576SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-3UTRENST00000409880ENST00000461133SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-3UTRENST00000409880ENST00000480013SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-3UTRENST00000409880ENST00000539981SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-3UTRENST00000437390ENST00000307312SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-3UTRENST00000437390ENST00000359576SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-3UTRENST00000437390ENST00000461133SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-3UTRENST00000437390ENST00000480013SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-3UTRENST00000437390ENST00000539981SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-intronENST00000251481ENST00000313350SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-intronENST00000251481ENST00000333778SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-intronENST00000251481ENST00000482896SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-intronENST00000251481ENST00000487200SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-intronENST00000326853ENST00000313350SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-intronENST00000326853ENST00000333778SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-intronENST00000326853ENST00000482896SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-intronENST00000326853ENST00000487200SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-intronENST00000409880ENST00000313350SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-intronENST00000409880ENST00000333778SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-intronENST00000409880ENST00000482896SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-intronENST00000409880ENST00000487200SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-intronENST00000437390ENST00000313350SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-intronENST00000437390ENST00000333778SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-intronENST00000437390ENST00000482896SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
5CDS-intronENST00000437390ENST00000487200SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
Frame-shiftENST00000251481ENST00000399362SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
Frame-shiftENST00000251481ENST00000468888SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
Frame-shiftENST00000326853ENST00000399362SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
Frame-shiftENST00000326853ENST00000468888SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
Frame-shiftENST00000409880ENST00000399362SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
Frame-shiftENST00000409880ENST00000468888SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
Frame-shiftENST00000437390ENST00000399362SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
Frame-shiftENST00000437390ENST00000468888SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
intron-3CDSENST00000492554ENST00000399362SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
intron-3CDSENST00000492554ENST00000468888SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
intron-3UTRENST00000492554ENST00000307312SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
intron-3UTRENST00000492554ENST00000359576SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
intron-3UTRENST00000492554ENST00000461133SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
intron-3UTRENST00000492554ENST00000480013SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
intron-3UTRENST00000492554ENST00000539981SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
intron-intronENST00000492554ENST00000313350SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
intron-intronENST00000492554ENST00000333778SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
intron-intronENST00000492554ENST00000482896SULT1C2chr2

108910810

+CLASP2chr3

33543260

-
intron-intronENST00000492554ENST00000487200SULT1C2chr2

108910810

+CLASP2chr3

33543260

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SULT1C2-CLASP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SULT1C2-CLASP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:108910810/:33543260)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CLASP2

O75122

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules (PubMed:26003921). Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2 (PubMed:16824950). This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle (PubMed:16866869, PubMed:16914514). Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:15631994, ECO:0000269|PubMed:16824950, ECO:0000269|PubMed:16866869, ECO:0000269|PubMed:16914514, ECO:0000269|PubMed:17543864, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:26003921}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SULT1C2-CLASP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SULT1C2-CLASP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SULT1C2-CLASP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SULT1C2-CLASP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource