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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:BACE2-TMPRSS2 (FusionGDB2 ID:8819) |
Fusion Gene Summary for BACE2-TMPRSS2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BACE2-TMPRSS2 | Fusion gene ID: 8819 | Hgene | Tgene | Gene symbol | BACE2 | TMPRSS2 | Gene ID | 25825 | 7113 |
| Gene name | beta-secretase 2 | transmembrane serine protease 2 | |
| Synonyms | AEPLC|ALP56|ASP1|ASP21|BAE2|CDA13|CEAP1|DRAP | PP9284|PRSS10 | |
| Cytomap | 21q22.2-q22.3 | 21q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | beta-secretase 256 kDa aspartic-like proteaseDown syndrome region aspartic proteaseSLCO3A1/BACE2 fusionaspartyl protease 1beta-site APP-cleaving enzyme 2beta-site amyloid beta A4 precursor protein-cleaving enzyme 2memapsin-1membrane-associated asp | transmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9Y5Z0 | O15393 | |
| Ensembl transtripts involved in fusion gene | ENST00000466122, ENST00000330333, ENST00000347667, ENST00000328735, | ENST00000332149, ENST00000398585, ENST00000458356, ENST00000497881, | |
| Fusion gene scores | * DoF score | 13 X 5 X 10=650 | 28 X 34 X 5=4760 |
| # samples | 15 | 35 | |
| ** MAII score | log2(15/650*10)=-2.11547721741994 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(35/4760*10)=-3.76553474636298 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: BACE2 [Title/Abstract] AND TMPRSS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | BACE2(42629253)-TMPRSS2(42848547), # samples:2 TMPRSS2(42858394)-BACE2(42576142), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | BACE2-TMPRSS2 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. BACE2-TMPRSS2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. BACE2-TMPRSS2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BACE2 | GO:0006509 | membrane protein ectodomain proteolysis | 10591213 |
| Tgene | TMPRSS2 | GO:0006508 | proteolysis | 21068237|24227843 |
| Tgene | TMPRSS2 | GO:0046598 | positive regulation of viral entry into host cell | 21068237|24227843 |
| Fusion gene breakpoints across BACE2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene breakpoints across TMPRSS2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | PRAD | TCGA-KC-A4BV-01A | BACE2 | chr21 | 42629253 | + | TMPRSS2 | chr21 | 42848547 | - |
| ChimerDB4 | PRAD | TCGA-KC-A4BV | BACE2 | chr21 | 42629253 | + | TMPRSS2 | chr21 | 42848547 | - |
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Fusion Gene ORF analysis for BACE2-TMPRSS2 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000466122 | ENST00000332149 | BACE2 | chr21 | 42629253 | + | TMPRSS2 | chr21 | 42848547 | - |
| 3UTR-3CDS | ENST00000466122 | ENST00000398585 | BACE2 | chr21 | 42629253 | + | TMPRSS2 | chr21 | 42848547 | - |
| 3UTR-3CDS | ENST00000466122 | ENST00000458356 | BACE2 | chr21 | 42629253 | + | TMPRSS2 | chr21 | 42848547 | - |
| 3UTR-intron | ENST00000466122 | ENST00000497881 | BACE2 | chr21 | 42629253 | + | TMPRSS2 | chr21 | 42848547 | - |
| 5CDS-intron | ENST00000330333 | ENST00000497881 | BACE2 | chr21 | 42629253 | + | TMPRSS2 | chr21 | 42848547 | - |
| 5CDS-intron | ENST00000347667 | ENST00000497881 | BACE2 | chr21 | 42629253 | + | TMPRSS2 | chr21 | 42848547 | - |
| Frame-shift | ENST00000330333 | ENST00000332149 | BACE2 | chr21 | 42629253 | + | TMPRSS2 | chr21 | 42848547 | - |
| Frame-shift | ENST00000330333 | ENST00000398585 | BACE2 | chr21 | 42629253 | + | TMPRSS2 | chr21 | 42848547 | - |
| Frame-shift | ENST00000330333 | ENST00000458356 | BACE2 | chr21 | 42629253 | + | TMPRSS2 | chr21 | 42848547 | - |
| Frame-shift | ENST00000347667 | ENST00000332149 | BACE2 | chr21 | 42629253 | + | TMPRSS2 | chr21 | 42848547 | - |
| Frame-shift | ENST00000347667 | ENST00000398585 | BACE2 | chr21 | 42629253 | + | TMPRSS2 | chr21 | 42848547 | - |
| Frame-shift | ENST00000347667 | ENST00000458356 | BACE2 | chr21 | 42629253 | + | TMPRSS2 | chr21 | 42848547 | - |
| intron-3CDS | ENST00000328735 | ENST00000332149 | BACE2 | chr21 | 42629253 | + | TMPRSS2 | chr21 | 42848547 | - |
| intron-3CDS | ENST00000328735 | ENST00000398585 | BACE2 | chr21 | 42629253 | + | TMPRSS2 | chr21 | 42848547 | - |
| intron-3CDS | ENST00000328735 | ENST00000458356 | BACE2 | chr21 | 42629253 | + | TMPRSS2 | chr21 | 42848547 | - |
| intron-intron | ENST00000328735 | ENST00000497881 | BACE2 | chr21 | 42629253 | + | TMPRSS2 | chr21 | 42848547 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for BACE2-TMPRSS2 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for BACE2-TMPRSS2 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:42629253/:42848547) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BACE2 | TMPRSS2 |
| FUNCTION: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142). {ECO:0000269|PubMed:10591213, ECO:0000269|PubMed:11083922, ECO:0000269|PubMed:11423558, ECO:0000269|PubMed:15857888, ECO:0000269|PubMed:16816112, ECO:0000269|PubMed:21907142}. | FUNCTION: Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity). {ECO:0000250|UniProtKB:Q9JIQ8, ECO:0000269|PubMed:15537383, ECO:0000269|PubMed:25122198, ECO:0000269|PubMed:26018085}.; FUNCTION: (Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry (PubMed:24227843, PubMed:32142651, PubMed:32404436, PubMed:34159616, PubMed:33051876). Upon SARS-CoV-2 infection, increases syncytia formation by accelerating the fusion process (PubMed:34159616, PubMed:33051876). Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity. {ECO:0000269|PubMed:21068237, ECO:0000269|PubMed:21325420, ECO:0000269|PubMed:23536651, ECO:0000269|PubMed:23966399, ECO:0000269|PubMed:24027332, ECO:0000269|PubMed:24227843, ECO:0000269|PubMed:32142651, ECO:0000269|PubMed:32404436, ECO:0000269|PubMed:33051876, ECO:0000269|PubMed:34159616}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for BACE2-TMPRSS2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
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Fusion Gene PPI Analysis for BACE2-TMPRSS2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for BACE2-TMPRSS2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for BACE2-TMPRSS2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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