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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:BACH1-DSCR3 (FusionGDB2 ID:8822)

Fusion Gene Summary for BACH1-DSCR3

Fusion gene summary

Fusion gene information	Fusion gene name: BACH1-DSCR3
	Fusion gene ID: 8822
		Hgene	Tgene
	Gene symbol	BACH1	DSCR3
	Gene ID	83990	10311
	Gene name	BRCA1 interacting protein C-terminal helicase 1	VPS26 endosomal protein sorting factor C
	Synonyms	BACH1\|FANCJ\|OF	DCRA\|DSCR3\|DSCRA
	Cytomap	17q23.2	21q22.13
	Type of gene	protein-coding	protein-coding
	Description	Fanconi anemia group J proteinATP-dependent RNA helicase BRIP1BRCA1-associated C-terminal helicase 1BRCA1-binding helicase-like protein BACH1BRCA1/BRCA2-associated helicase 1	vacuolar protein sorting-associated protein 26CDSCR3 arrestin fold containingDown syndrome critical region 3Down syndrome critical region gene 3Down syndrome critical region protein 3Down syndrome critical region protein A
	Modification date	20200315	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000286800, ENST00000399921, ENST00000462262,	ENST00000288304, ENST00000399000, ENST00000539844, ENST00000398998, ENST00000399001, ENST00000476950, ENST00000309117,
Fusion gene scores	* DoF score	7 X 4 X 7=196	5 X 1 X 4=20
	# samples	7	5
	** MAII score	log2(7/196*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/20*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: BACH1 [Title/Abstract] AND DSCR3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	BACH1(30702014)-DSCR3(38612940), # samples:3 DSCR3(38639539)-BACH1(30642678), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	BACH1	GO:0006357	regulation of transcription by RNA polymerase II	14504288

Fusion gene breakpoints across BACH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DSCR3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CQ-7065-01A	BACH1	chr21	30702014	-	DSCR3	chr21	38612940	-
ChimerDB4	HNSC	TCGA-CQ-7065-01A	BACH1	chr21	30702014	+	DSCR3	chr21	38612940	-
ChimerDB4	HNSC	TCGA-CQ-7065	BACH1	chr21	30702014	+	DSCR3	chr21	38612940	-

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Fusion Gene ORF analysis for BACH1-DSCR3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000286800	ENST00000288304	BACH1	chr21	30702014	+	DSCR3	chr21	38612940	-
5CDS-5UTR	ENST00000286800	ENST00000399000	BACH1	chr21	30702014	+	DSCR3	chr21	38612940	-
5CDS-5UTR	ENST00000286800	ENST00000539844	BACH1	chr21	30702014	+	DSCR3	chr21	38612940	-
5CDS-5UTR	ENST00000399921	ENST00000288304	BACH1	chr21	30702014	+	DSCR3	chr21	38612940	-
5CDS-5UTR	ENST00000399921	ENST00000399000	BACH1	chr21	30702014	+	DSCR3	chr21	38612940	-
5CDS-5UTR	ENST00000399921	ENST00000539844	BACH1	chr21	30702014	+	DSCR3	chr21	38612940	-
5CDS-intron	ENST00000286800	ENST00000398998	BACH1	chr21	30702014	+	DSCR3	chr21	38612940	-
5CDS-intron	ENST00000286800	ENST00000399001	BACH1	chr21	30702014	+	DSCR3	chr21	38612940	-
5CDS-intron	ENST00000286800	ENST00000476950	BACH1	chr21	30702014	+	DSCR3	chr21	38612940	-
5CDS-intron	ENST00000399921	ENST00000398998	BACH1	chr21	30702014	+	DSCR3	chr21	38612940	-
5CDS-intron	ENST00000399921	ENST00000399001	BACH1	chr21	30702014	+	DSCR3	chr21	38612940	-
5CDS-intron	ENST00000399921	ENST00000476950	BACH1	chr21	30702014	+	DSCR3	chr21	38612940	-
In-frame	ENST00000286800	ENST00000309117	BACH1	chr21	30702014	+	DSCR3	chr21	38612940	-
In-frame	ENST00000399921	ENST00000309117	BACH1	chr21	30702014	+	DSCR3	chr21	38612940	-
intron-3CDS	ENST00000462262	ENST00000309117	BACH1	chr21	30702014	+	DSCR3	chr21	38612940	-
intron-5UTR	ENST00000462262	ENST00000288304	BACH1	chr21	30702014	+	DSCR3	chr21	38612940	-
intron-5UTR	ENST00000462262	ENST00000399000	BACH1	chr21	30702014	+	DSCR3	chr21	38612940	-
intron-5UTR	ENST00000462262	ENST00000539844	BACH1	chr21	30702014	+	DSCR3	chr21	38612940	-
intron-intron	ENST00000462262	ENST00000398998	BACH1	chr21	30702014	+	DSCR3	chr21	38612940	-
intron-intron	ENST00000462262	ENST00000399001	BACH1	chr21	30702014	+	DSCR3	chr21	38612940	-
intron-intron	ENST00000462262	ENST00000476950	BACH1	chr21	30702014	+	DSCR3	chr21	38612940	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000286800

BACH1

chr21

30702014

ENST00000309117

DSCR3

chr21

38612940

4880

1919

131

2755

874

ENST00000399921

BACH1

chr21

30702014

ENST00000309117

DSCR3

chr21

38612940

4980

2019

231

2855

874

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000286800	ENST00000309117	BACH1	chr21	30702014	+	DSCR3	chr21	38612940	-	0.000589534	0.9994105
ENST00000399921	ENST00000309117	BACH1	chr21	30702014	+	DSCR3	chr21	38612940	-	0.000531647	0.9994684

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Fusion Genomic Features for BACH1-DSCR3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for BACH1-DSCR3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:30702014/chr21:38612940)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BACH1

chr21:30702014

chr21:38612940

ENST00000286800

34_100

592

737.0

Domain

BTB

Hgene

BACH1

chr21:30702014

chr21:38612940

ENST00000399921

34_100

592

737.0

Domain

BTB

Hgene

BACH1

chr21:30702014

chr21:38612940

ENST00000286800

562_578

592

737.0

Region

Basic motif

Hgene

BACH1

chr21:30702014

chr21:38612940

ENST00000286800

582_589

592

737.0

Region

Leucine-zipper

Hgene

BACH1

chr21:30702014

chr21:38612940

ENST00000399921

562_578

592

737.0

Region

Basic motif

Hgene

BACH1

chr21:30702014

chr21:38612940

ENST00000399921

582_589

592

737.0

Region

Leucine-zipper

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

BACH1

chr21:30702014

chr21:38612940

ENST00000286800

557_620

592

737.0

Domain

bZIP

Hgene

BACH1

chr21:30702014

chr21:38612940

ENST00000399921

557_620

592

737.0

Domain

bZIP

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Fusion Gene Sequence for BACH1-DSCR3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>8822_8822_1_BACH1-DSCR3_BACH1_chr21_30702014_ENST00000286800_DSCR3_chr21_38612940_ENST00000309117_length(transcript)=4880nt_BP=1919nt
GAGTGAGTCACCTGACCGCTGCCCTCGCCGCCCGCCGGGCGCTCTCGCTTCAGTCAGTCGGGCCGCGCCGCGCCTCAGCTCTGGTTGATG
ATAATTAGAAGCATGCTTTCCACTGAACTTCCCGACAACATTTGTTATGCAGAATGTCTCTGAGTGAGAACTCGGTTTTTGCCTATGAAT
CTTCTGTGCATAGCACCAATGTTTTACTCAGCCTTAATGACCAGCGGAAGAAAGATGTGCTGTGCGATGTCACCATCTTTGTGGAGGGAC
AGCGGTTCCGCGCTCACCGGTCCGTGCTGGCGGCATGCAGCAGTTACTTCCACTCAAGAATCGTAGGCCAGGCTGATGGAGAGCTGAACA
TTACTCTTCCAGAAGAGGTGACAGTTAAAGGATTTGAACCTTTAATTCAGTTTGCCTACACTGCTAAACTGATTTTAAGTAAAGAGAATG
TGGATGAAGTGTGCAAATGTGTGGAGTTTTTAAGTGTACATAATATTGAGGAATCCTGCTTTCAGTTTCTGAAATTTAAGTTTTTGGACT
CCACTGCAGACCAGCAAGAATGCCCAAGAAAAAAATGCTTTTCATCACACTGTCAGAAAACAGACCTTAAACTTTCACTTTTGGACCAGA
GGGATCTAGAAACTGATGAAGTGGAGGAATTTCTGGAAAATAAAAATGTTCAGACTCCTCAGTGTAAACTCCGCAGGTATCAAGGAAATG
CAAAAGCCTCACCTCCTCTACAAGACAGTGCCAGTCAGACATATGAGTCCATGTGCTTAGAGAAGGATGCTGCTCTGGCCTTGCCTTCTT
TATGCCCCAAATACAGAAAATTCCAAAAAGCATTTGGAACTGACAGAGTCCGTACTGGGGAATCTAGTGTCAAAGACATTCATGCTTCTG
TTCAGCCAAATGAAAGGTCTGAAAATGAATGCCTGGGAGGAGTCCCGGAGTGTAGAGATTTGCAGGTGATGTTAAAATGTGACGAAAGTA
AATTAGCAATGGAACCTGAAGAAACGAAGAAAGATCCTGCTTCTCAGTGCCCAACTGAAAAATCAGAAGTGACTCCTTTCCCCCACAATT
CTTCCATAGACCCTCATGGACTTTATTCTTTGTCTCTTTTACACACATATGACCAATATGGTGACTTGAATTTTGCTGGTATGCAAAACA
CAACAGTGTTAACAGAAAAGCCTTTGTCAGGTACAGACGTCCAAGAAAAAACATTTGGTGAAAGTCAGGATTTACCTTTGAAATCCGACT
TGGGCACCAGGGAAGATAGTAGTGTTGCATCTAGTGATAGGAGTAGTGTGGAGCGAGAAGTGGCAGAACACCTAGCAAAAGGCTTCTGGA
GTGACATTTGCAGCACGGACACTCCTTGCCAAATGCAGTTATCACCTGCTGTGGCCAAAGATGGCTCAGAACAGATCTCACAGAAACGGT
CTGAGTGTCCGTGGTTAGGTATCAGGATTAGTGAGAGCCCAGAACCAGGTCAAAGGACTTTCACAACATTAAGTTCTGTCAACTGCCCTT
TTATAAGTACTCTGAGTACTGAAGGCTGTTCAAGCAATTTGGAAATTGGAAACGATGATTATGTTTCAGAACCCCAGCAAGAACCTTGCC
CATATGCTTGTGTCATTAGCTTGGGAGACGACTCTGAGACGGACACCGAAGGAGACAGTGAATCCTGTTCAGCCAGAGAACAAGAATGTG
AGGTAAAACTGCCATTCAATGCACAACGGATAATTTCACTGTCTCGAAATGATTTTCAGTCCTTGTTGAAAATGCACAAGCTTACTCCAG
AACAGCTGGATTGTATCCATGATATTCGAAGAAGAAGTAAAAACAGAATTGCTGCACAGCGCTGTCGCAAGAGAAAACTTGACTGTATAC
AGAATCTTGAATCAGAAATTGAGAAGCTGGAAGTGCTCTCTGGCGTGGTGGTCATATCGAGTAAGGATTCAGTCCAACACCAGGGAGTGT
CTTTGACCATGGAAGGAACTGTAAACCTCCAGCTCAGTGCCAAAAGTGTGGGTGTGTTTGAAGCTTTTTATAATTCTGTTAAGCCTATCC
AGATTATCAACAGCACCATAGAAATGGTGAAGCCGGGGAAATTTCCCAGCGGCAAAACAGAAATCCCTTTTGAATTTCCTCTGCACTTGA
AGGGTAACAAAGTTCTGTATGAGACGTATCATGGCGTGTTTGTCAACATTCAGTATACACTGCGCTGTGACATGAAGCGGTCTCTGTTGG
CCAAGGACTTGACAAAGACCTGTGAATTTATCGTTCACTCCGCTCCTCAGAAGGGGAAGTTTACTCCCAGTCCCGTGGACTTCACGATTA
CACCTGAAACCTTACAGAACGTCAAAGAGAGAGCTTTGCTTCCCAAATTTCTCCTTCGAGGACATCTCAACTCAACAAACTGTGTCATCA
CGCAGCCACTAACGGGAGAGCTGGTGGTGGAGAGCTCGGAAGCCGCCATCAGAAGCGTGGAGCTGCAGCTGGTGCGCGTGGAGACGTGCG
GGTGTGCAGAAGGCTATGCCCGCGACGCCACGGAGATTCAGAACATTCAGATCGCCGACGGGGATGTGTGCAGGGGCCTCTCTGTCCCCA
TCTACATGGTCTTCCCTAGGCTGTTCACCTGCCCTACACTGGAGACCACCAACTTCAAAGTGGAATTTGAGGTTAACATCGTGGTGCTGC
TTCACCCTGACCACCTCATCACGGAGAACTTCCCGCTGAAGCTCTGCAGGATATAGCCCGGAGGAGGGAAGCATAGAGAACGGGAGTGGC
CATCTGGAAATCCAGCTGGTTATCCAAATCCTAAGGGGAGCTACAGCCAGCGGCATATACTTGTTTTTGTGATTATTCTGTATCAGAAAT
GAAACAGACCCTCAAATTAACTTTCCTTCCTCATTTCTTGAGGCTTCTGCTTCCAACAGGCACCTCTAATCAGACCTTTTCTTTGAAATT
CAACAAGATTTCTTAATGCTATTTGCCAAGACCATTTCACAGAAAACATTGACTGTGGCTCTTGCCTTATCTGTTCCTTTTTAGGTACAG
TAAAACAATTGTGACAGCAGTTTGAGCTTGCTGGAGAGTGGCATCATGGGGACAAAAGGAAACCTCTGACTTGCTAATGGATGTAGCCAG
GGACTCCCCATAGCAAAGGGTCTGTGGCCAGTTGACATCCAGGATGGCTGCAAGCGCACTTGATGGTCAGGAAGTTTGCAGATACTCGCC
AAGGCAGAGCGCAAAGTGCTAGCCACTGGAAATGCATGACTTCCCTCCACCCCTACTCTATTCTGTAGTTTTTTGGTTTTGTTTCTGAGA
CGGAGTCTCAGTCTGTCACCCAGGCTGGAGTGATCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCGACTCTCCTGCCTCAGCCT
CCCGAGTAGTTGGGATTACAGGTGACTGCCACCGTGCCCGGCTAATGTTTGTATTTTTAGTAGAGACGGGGCTTCACCATCTTGGCCAGG
CTGGTCTTGAACTCCTGACCTCGTGACCCACCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACACCCAGCCTCTG
TAGTTCTTTTTACAACATTTTTCATTATAACTTTAAATTTTTTAAGCAACTGGAAAAGTGTTCCTTGCTCTCTTGGGGGGATTTGGCTGG
TGCCGAAGTGTTTCTGAAGTCTCAAGAACTGCCATAAAATCTCACGCTGCCATTTCCCTGAACAGATACATACATAGAGAGAGACAGTTT
TCCAAACTGTGTCACGCAGGCTGAGTGCACTGGCAGGATCACAGCTCACGGCAGCCTCAACCTCCCTGGCTCAAGCGATCCCTCCCCTCA
GCCTCCTGAGTAGCTGAGACTACAGGTGAGTGCCACCACACTCAGCTAATTTTCAAATTTTTTGTAGACAGGGTCTCCCTATGTTGCCCA
GGCTGGTCTTGAACTCCTAGACTCAAGTGATCCTCCTGTCTTGGCCTCCCAAAGTGCTGAGATTACAGGTGTGAGCCACTGTGCCCAGCA
GTTTCCCAGAATATATTTAAATGCAAAGTTACATGAGGGGAAAACATGTATGTTTGCTCCTGTTGTTACTGGGTAGGTTCTGAACAGCAG
AAACCCATGTGCAGGGTGGGCTGGTGAAGGCCCCTCTCCGCAAGGTGGTAGCAGGAAAAGGTCCTTGACTTGATGAATTTGGTCTGCCTC
TGAGCCACTGGAGGAAGCTGTTTTGAGCCAGGGTTTTTTGGCCTAAAGCCAGCATTTCCTCAGTCTCCCTTTGTGGTTCGAAGGATATGG
ACTATTGCAATACATTTCTTCCTTCAAATCCTGCCACTGTTTTGTTGGCCCACAACTAATAGGACCTCAAAATAAGCCATGCTGCTTTGC
ACACACACTAGCCTTCTTTTGTACTTTTCATTCTGGATGGGCTTGGCCAAAACAGGCTCAGGCCAAAGACCTCCCAAGCTGTATGTACTT
CCAGTATCCTGAAACAGTGTTTGGTGACATAATGCCAAGGGTAAACAAGCCTGATTTAGGCACTGCTTTATCCAGGGGCTTCACCCATGA
AATTAATAAAACTTATCTGAGTCACTTGAAACTTGGTTCCCAGAAAACACATTTCTGGTTTATAATCTCCTTTTATGCTCACCTGACATT
AATTATCTATCCTTGATGATGTGTTTAAACTGAGTAGCAGAAAACAGAGGCCACACTTTCTGGGAAATTTTAAAGGAAGAAACCATTTTT
AATGAGATGAAAATATTTAACGAATTTAAAAAGCTAATGACAATTTTGAGAAAAGGTTTGGGATGTATATTGCTATGTAATTTAATAAAC

>8822_8822_1_BACH1-DSCR3_BACH1_chr21_30702014_ENST00000286800_DSCR3_chr21_38612940_ENST00000309117_length(amino acids)=874AA_BP=596
MLCRMSLSENSVFAYESSVHSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQADGELNITLPEEVTVKGFEP
LIQFAYTAKLILSKENVDEVCKCVEFLSVHNIEESCFQFLKFKFLDSTADQQECPRKKCFSSHCQKTDLKLSLLDQRDLETDEVEEFLEN
KNVQTPQCKLRRYQGNAKASPPLQDSASQTYESMCLEKDAALALPSLCPKYRKFQKAFGTDRVRTGESSVKDIHASVQPNERSENECLGG
VPECRDLQVMLKCDESKLAMEPEETKKDPASQCPTEKSEVTPFPHNSSIDPHGLYSLSLLHTYDQYGDLNFAGMQNTTVLTEKPLSGTDV
QEKTFGESQDLPLKSDLGTREDSSVASSDRSSVEREVAEHLAKGFWSDICSTDTPCQMQLSPAVAKDGSEQISQKRSECPWLGIRISESP
EPGQRTFTTLSSVNCPFISTLSTEGCSSNLEIGNDDYVSEPQQEPCPYACVISLGDDSETDTEGDSESCSAREQECEVKLPFNAQRIISL
SRNDFQSLLKMHKLTPEQLDCIHDIRRRSKNRIAAQRCRKRKLDCIQNLESEIEKLEVLSGVVVISSKDSVQHQGVSLTMEGTVNLQLSA
KSVGVFEAFYNSVKPIQIINSTIEMVKPGKFPSGKTEIPFEFPLHLKGNKVLYETYHGVFVNIQYTLRCDMKRSLLAKDLTKTCEFIVHS
APQKGKFTPSPVDFTITPETLQNVKERALLPKFLLRGHLNSTNCVITQPLTGELVVESSEAAIRSVELQLVRVETCGCAEGYARDATEIQ

--------------------------------------------------------------
>8822_8822_2_BACH1-DSCR3_BACH1_chr21_30702014_ENST00000399921_DSCR3_chr21_38612940_ENST00000309117_length(transcript)=4980nt_BP=2019nt
GTCTACTCAGCCCGGTGGCTGTCGCGCGTGGAATCGCGTAAGAAAAGCCGAGTTTGTGGCTGGGGAGAGAAGGCCACCGTGCTGAGCTGG
ATTTAGCGAAGACTGGTTTTGGGGACCGGAGAGCCCAGGACTCCCTTTGTTGGAGTTTTGCCCACGCGTTGTAATTAAGCCTCGCACAAT
ATGGTTGATGATAATTAGAAGCATGCTTTCCACTGAACTTCCCGACAACATTTGTTATGCAGAATGTCTCTGAGTGAGAACTCGGTTTTT
GCCTATGAATCTTCTGTGCATAGCACCAATGTTTTACTCAGCCTTAATGACCAGCGGAAGAAAGATGTGCTGTGCGATGTCACCATCTTT
GTGGAGGGACAGCGGTTCCGCGCTCACCGGTCCGTGCTGGCGGCATGCAGCAGTTACTTCCACTCAAGAATCGTAGGCCAGGCTGATGGA
GAGCTGAACATTACTCTTCCAGAAGAGGTGACAGTTAAAGGATTTGAACCTTTAATTCAGTTTGCCTACACTGCTAAACTGATTTTAAGT
AAAGAGAATGTGGATGAAGTGTGCAAATGTGTGGAGTTTTTAAGTGTACATAATATTGAGGAATCCTGCTTTCAGTTTCTGAAATTTAAG
TTTTTGGACTCCACTGCAGACCAGCAAGAATGCCCAAGAAAAAAATGCTTTTCATCACACTGTCAGAAAACAGACCTTAAACTTTCACTT
TTGGACCAGAGGGATCTAGAAACTGATGAAGTGGAGGAATTTCTGGAAAATAAAAATGTTCAGACTCCTCAGTGTAAACTCCGCAGGTAT
CAAGGAAATGCAAAAGCCTCACCTCCTCTACAAGACAGTGCCAGTCAGACATATGAGTCCATGTGCTTAGAGAAGGATGCTGCTCTGGCC
TTGCCTTCTTTATGCCCCAAATACAGAAAATTCCAAAAAGCATTTGGAACTGACAGAGTCCGTACTGGGGAATCTAGTGTCAAAGACATT
CATGCTTCTGTTCAGCCAAATGAAAGGTCTGAAAATGAATGCCTGGGAGGAGTCCCGGAGTGTAGAGATTTGCAGGTGATGTTAAAATGT
GACGAAAGTAAATTAGCAATGGAACCTGAAGAAACGAAGAAAGATCCTGCTTCTCAGTGCCCAACTGAAAAATCAGAAGTGACTCCTTTC
CCCCACAATTCTTCCATAGACCCTCATGGACTTTATTCTTTGTCTCTTTTACACACATATGACCAATATGGTGACTTGAATTTTGCTGGT
ATGCAAAACACAACAGTGTTAACAGAAAAGCCTTTGTCAGGTACAGACGTCCAAGAAAAAACATTTGGTGAAAGTCAGGATTTACCTTTG
AAATCCGACTTGGGCACCAGGGAAGATAGTAGTGTTGCATCTAGTGATAGGAGTAGTGTGGAGCGAGAAGTGGCAGAACACCTAGCAAAA
GGCTTCTGGAGTGACATTTGCAGCACGGACACTCCTTGCCAAATGCAGTTATCACCTGCTGTGGCCAAAGATGGCTCAGAACAGATCTCA
CAGAAACGGTCTGAGTGTCCGTGGTTAGGTATCAGGATTAGTGAGAGCCCAGAACCAGGTCAAAGGACTTTCACAACATTAAGTTCTGTC
AACTGCCCTTTTATAAGTACTCTGAGTACTGAAGGCTGTTCAAGCAATTTGGAAATTGGAAACGATGATTATGTTTCAGAACCCCAGCAA
GAACCTTGCCCATATGCTTGTGTCATTAGCTTGGGAGACGACTCTGAGACGGACACCGAAGGAGACAGTGAATCCTGTTCAGCCAGAGAA
CAAGAATGTGAGGTAAAACTGCCATTCAATGCACAACGGATAATTTCACTGTCTCGAAATGATTTTCAGTCCTTGTTGAAAATGCACAAG
CTTACTCCAGAACAGCTGGATTGTATCCATGATATTCGAAGAAGAAGTAAAAACAGAATTGCTGCACAGCGCTGTCGCAAGAGAAAACTT
GACTGTATACAGAATCTTGAATCAGAAATTGAGAAGCTGGAAGTGCTCTCTGGCGTGGTGGTCATATCGAGTAAGGATTCAGTCCAACAC
CAGGGAGTGTCTTTGACCATGGAAGGAACTGTAAACCTCCAGCTCAGTGCCAAAAGTGTGGGTGTGTTTGAAGCTTTTTATAATTCTGTT
AAGCCTATCCAGATTATCAACAGCACCATAGAAATGGTGAAGCCGGGGAAATTTCCCAGCGGCAAAACAGAAATCCCTTTTGAATTTCCT
CTGCACTTGAAGGGTAACAAAGTTCTGTATGAGACGTATCATGGCGTGTTTGTCAACATTCAGTATACACTGCGCTGTGACATGAAGCGG
TCTCTGTTGGCCAAGGACTTGACAAAGACCTGTGAATTTATCGTTCACTCCGCTCCTCAGAAGGGGAAGTTTACTCCCAGTCCCGTGGAC
TTCACGATTACACCTGAAACCTTACAGAACGTCAAAGAGAGAGCTTTGCTTCCCAAATTTCTCCTTCGAGGACATCTCAACTCAACAAAC
TGTGTCATCACGCAGCCACTAACGGGAGAGCTGGTGGTGGAGAGCTCGGAAGCCGCCATCAGAAGCGTGGAGCTGCAGCTGGTGCGCGTG
GAGACGTGCGGGTGTGCAGAAGGCTATGCCCGCGACGCCACGGAGATTCAGAACATTCAGATCGCCGACGGGGATGTGTGCAGGGGCCTC
TCTGTCCCCATCTACATGGTCTTCCCTAGGCTGTTCACCTGCCCTACACTGGAGACCACCAACTTCAAAGTGGAATTTGAGGTTAACATC
GTGGTGCTGCTTCACCCTGACCACCTCATCACGGAGAACTTCCCGCTGAAGCTCTGCAGGATATAGCCCGGAGGAGGGAAGCATAGAGAA
CGGGAGTGGCCATCTGGAAATCCAGCTGGTTATCCAAATCCTAAGGGGAGCTACAGCCAGCGGCATATACTTGTTTTTGTGATTATTCTG
TATCAGAAATGAAACAGACCCTCAAATTAACTTTCCTTCCTCATTTCTTGAGGCTTCTGCTTCCAACAGGCACCTCTAATCAGACCTTTT
CTTTGAAATTCAACAAGATTTCTTAATGCTATTTGCCAAGACCATTTCACAGAAAACATTGACTGTGGCTCTTGCCTTATCTGTTCCTTT
TTAGGTACAGTAAAACAATTGTGACAGCAGTTTGAGCTTGCTGGAGAGTGGCATCATGGGGACAAAAGGAAACCTCTGACTTGCTAATGG
ATGTAGCCAGGGACTCCCCATAGCAAAGGGTCTGTGGCCAGTTGACATCCAGGATGGCTGCAAGCGCACTTGATGGTCAGGAAGTTTGCA
GATACTCGCCAAGGCAGAGCGCAAAGTGCTAGCCACTGGAAATGCATGACTTCCCTCCACCCCTACTCTATTCTGTAGTTTTTTGGTTTT
GTTTCTGAGACGGAGTCTCAGTCTGTCACCCAGGCTGGAGTGATCTCAGCTCACTGCAACCTCCACCTCCCAGGTTCAAGCGACTCTCCT
GCCTCAGCCTCCCGAGTAGTTGGGATTACAGGTGACTGCCACCGTGCCCGGCTAATGTTTGTATTTTTAGTAGAGACGGGGCTTCACCAT
CTTGGCCAGGCTGGTCTTGAACTCCTGACCTCGTGACCCACCCGCCTTGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCACAC
CCAGCCTCTGTAGTTCTTTTTACAACATTTTTCATTATAACTTTAAATTTTTTAAGCAACTGGAAAAGTGTTCCTTGCTCTCTTGGGGGG
ATTTGGCTGGTGCCGAAGTGTTTCTGAAGTCTCAAGAACTGCCATAAAATCTCACGCTGCCATTTCCCTGAACAGATACATACATAGAGA
GAGACAGTTTTCCAAACTGTGTCACGCAGGCTGAGTGCACTGGCAGGATCACAGCTCACGGCAGCCTCAACCTCCCTGGCTCAAGCGATC
CCTCCCCTCAGCCTCCTGAGTAGCTGAGACTACAGGTGAGTGCCACCACACTCAGCTAATTTTCAAATTTTTTGTAGACAGGGTCTCCCT
ATGTTGCCCAGGCTGGTCTTGAACTCCTAGACTCAAGTGATCCTCCTGTCTTGGCCTCCCAAAGTGCTGAGATTACAGGTGTGAGCCACT
GTGCCCAGCAGTTTCCCAGAATATATTTAAATGCAAAGTTACATGAGGGGAAAACATGTATGTTTGCTCCTGTTGTTACTGGGTAGGTTC
TGAACAGCAGAAACCCATGTGCAGGGTGGGCTGGTGAAGGCCCCTCTCCGCAAGGTGGTAGCAGGAAAAGGTCCTTGACTTGATGAATTT
GGTCTGCCTCTGAGCCACTGGAGGAAGCTGTTTTGAGCCAGGGTTTTTTGGCCTAAAGCCAGCATTTCCTCAGTCTCCCTTTGTGGTTCG
AAGGATATGGACTATTGCAATACATTTCTTCCTTCAAATCCTGCCACTGTTTTGTTGGCCCACAACTAATAGGACCTCAAAATAAGCCAT
GCTGCTTTGCACACACACTAGCCTTCTTTTGTACTTTTCATTCTGGATGGGCTTGGCCAAAACAGGCTCAGGCCAAAGACCTCCCAAGCT
GTATGTACTTCCAGTATCCTGAAACAGTGTTTGGTGACATAATGCCAAGGGTAAACAAGCCTGATTTAGGCACTGCTTTATCCAGGGGCT
TCACCCATGAAATTAATAAAACTTATCTGAGTCACTTGAAACTTGGTTCCCAGAAAACACATTTCTGGTTTATAATCTCCTTTTATGCTC
ACCTGACATTAATTATCTATCCTTGATGATGTGTTTAAACTGAGTAGCAGAAAACAGAGGCCACACTTTCTGGGAAATTTTAAAGGAAGA
AACCATTTTTAATGAGATGAAAATATTTAACGAATTTAAAAAGCTAATGACAATTTTGAGAAAAGGTTTGGGATGTATATTGCTATGTAA

>8822_8822_2_BACH1-DSCR3_BACH1_chr21_30702014_ENST00000399921_DSCR3_chr21_38612940_ENST00000309117_length(amino acids)=874AA_BP=596
MLCRMSLSENSVFAYESSVHSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQADGELNITLPEEVTVKGFEP
LIQFAYTAKLILSKENVDEVCKCVEFLSVHNIEESCFQFLKFKFLDSTADQQECPRKKCFSSHCQKTDLKLSLLDQRDLETDEVEEFLEN
KNVQTPQCKLRRYQGNAKASPPLQDSASQTYESMCLEKDAALALPSLCPKYRKFQKAFGTDRVRTGESSVKDIHASVQPNERSENECLGG
VPECRDLQVMLKCDESKLAMEPEETKKDPASQCPTEKSEVTPFPHNSSIDPHGLYSLSLLHTYDQYGDLNFAGMQNTTVLTEKPLSGTDV
QEKTFGESQDLPLKSDLGTREDSSVASSDRSSVEREVAEHLAKGFWSDICSTDTPCQMQLSPAVAKDGSEQISQKRSECPWLGIRISESP
EPGQRTFTTLSSVNCPFISTLSTEGCSSNLEIGNDDYVSEPQQEPCPYACVISLGDDSETDTEGDSESCSAREQECEVKLPFNAQRIISL
SRNDFQSLLKMHKLTPEQLDCIHDIRRRSKNRIAAQRCRKRKLDCIQNLESEIEKLEVLSGVVVISSKDSVQHQGVSLTMEGTVNLQLSA
KSVGVFEAFYNSVKPIQIINSTIEMVKPGKFPSGKTEIPFEFPLHLKGNKVLYETYHGVFVNIQYTLRCDMKRSLLAKDLTKTCEFIVHS
APQKGKFTPSPVDFTITPETLQNVKERALLPKFLLRGHLNSTNCVITQPLTGELVVESSEAAIRSVELQLVRVETCGCAEGYARDATEIQ

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Top

Fusion Gene PPI Analysis for BACH1-DSCR3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for BACH1-DSCR3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for BACH1-DSCR3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source