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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SYCP2-BCL2L1 (FusionGDB2 ID:88332)

Fusion Gene Summary for SYCP2-BCL2L1

Fusion gene summary

Fusion gene information	Fusion gene name: SYCP2-BCL2L1
	Fusion gene ID: 88332
		Hgene	Tgene
	Gene symbol	SYCP2	BCL2L1
	Gene ID	10388	598
	Gene name	synaptonemal complex protein 2	BCL2 like 1
	Synonyms	SCP-2\|SCP2\|SPGF1	BCL-XL/S\|BCL2L\|BCLX\|Bcl-X\|PPP1R52
	Cytomap	20q13.33	20q11.21
	Type of gene	protein-coding	protein-coding
	Description	synaptonemal complex protein 2synaptonemal complex lateral element protein	bcl-2-like protein 1apoptosis regulator Bcl-Xprotein phosphatase 1, regulatory subunit 52
	Modification date	20200313	20200327
	UniProtAcc	.	Q9BZR8
	Ensembl transtripts involved in fusion gene	ENST00000357552, ENST00000371001, ENST00000476314,	ENST00000307677, ENST00000376055, ENST00000420653, ENST00000376062,
Fusion gene scores	* DoF score	4 X 4 X 3=48	10 X 5 X 10=500
	# samples	5	11
	** MAII score	log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(11/500*10)=-2.18442457113743 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SYCP2 [Title/Abstract] AND BCL2L1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SYCP2(58440443)-BCL2L1(30253889), # samples:1
Anticipated loss of major functional domain due to fusion event.	SYCP2-BCL2L1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. SYCP2-BCL2L1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	BCL2L1	GO:0001836	release of cytochrome c from mitochondria	9843949
Tgene	BCL2L1	GO:0019050	suppression by virus of host apoptotic process	15231831
Tgene	BCL2L1	GO:0034097	response to cytokine	9184696
Tgene	BCL2L1	GO:0043066	negative regulation of apoptotic process	7650367\|9388232
Tgene	BCL2L1	GO:0046902	regulation of mitochondrial membrane permeability	9843949
Tgene	BCL2L1	GO:0051881	regulation of mitochondrial membrane potential	9843949
Tgene	BCL2L1	GO:1900118	negative regulation of execution phase of apoptosis	20673843
Tgene	BCL2L1	GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	26582200
Tgene	BCL2L1	GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage	16608847
Tgene	BCL2L1	GO:1902236	negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	29507230
Tgene	BCL2L1	GO:1903077	negative regulation of protein localization to plasma membrane	21041309
Tgene	BCL2L1	GO:2001243	negative regulation of intrinsic apoptotic signaling pathway	12011449

Fusion gene breakpoints across SYCP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across BCL2L1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-G3-A25X-01A	SYCP2	chr20	58440443	-	BCL2L1	chr20	30253889	-

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Fusion Gene ORF analysis for SYCP2-BCL2L1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000357552	ENST00000307677	SYCP2	chr20	58440443	-	BCL2L1	chr20	30253889	-
Frame-shift	ENST00000357552	ENST00000376055	SYCP2	chr20	58440443	-	BCL2L1	chr20	30253889	-
Frame-shift	ENST00000357552	ENST00000420653	SYCP2	chr20	58440443	-	BCL2L1	chr20	30253889	-
Frame-shift	ENST00000371001	ENST00000307677	SYCP2	chr20	58440443	-	BCL2L1	chr20	30253889	-
Frame-shift	ENST00000371001	ENST00000376062	SYCP2	chr20	58440443	-	BCL2L1	chr20	30253889	-
In-frame	ENST00000357552	ENST00000376062	SYCP2	chr20	58440443	-	BCL2L1	chr20	30253889	-
In-frame	ENST00000371001	ENST00000376055	SYCP2	chr20	58440443	-	BCL2L1	chr20	30253889	-
In-frame	ENST00000371001	ENST00000420653	SYCP2	chr20	58440443	-	BCL2L1	chr20	30253889	-
intron-3CDS	ENST00000476314	ENST00000307677	SYCP2	chr20	58440443	-	BCL2L1	chr20	30253889	-
intron-3CDS	ENST00000476314	ENST00000376055	SYCP2	chr20	58440443	-	BCL2L1	chr20	30253889	-
intron-3CDS	ENST00000476314	ENST00000376062	SYCP2	chr20	58440443	-	BCL2L1	chr20	30253889	-
intron-3CDS	ENST00000476314	ENST00000420653	SYCP2	chr20	58440443	-	BCL2L1	chr20	30253889	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000357552	SYCP2	chr20	58440443	-	ENST00000376062	BCL2L1	chr20	30253889	-	6376	4741	151	4878	1575
ENST00000371001	SYCP2	chr20	58440443	-	ENST00000376055	BCL2L1	chr20	30253889	-	6289	4654	64	4791	1575
ENST00000371001	SYCP2	chr20	58440443	-	ENST00000420653	BCL2L1	chr20	30253889	-	6281	4654	64	4791	1575

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000357552	ENST00000376062	SYCP2	chr20	58440443	-	BCL2L1	chr20	30253889	-	0.000430277	0.9995697
ENST00000371001	ENST00000376055	SYCP2	chr20	58440443	-	BCL2L1	chr20	30253889	-	0.000380651	0.99961936
ENST00000371001	ENST00000420653	SYCP2	chr20	58440443	-	BCL2L1	chr20	30253889	-	0.000371849	0.9996282

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Fusion Genomic Features for SYCP2-BCL2L1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SYCP2-BCL2L1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:58440443/chr20:30253889)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	BCL2L1 Q9BZR8
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Plays a role in apoptosis.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SYCP2

chr20:58440443

chr20:30253889

ENST00000357552

655_660

1505

1531.0

Compositional bias

Note=Poly-Ser

Hgene

SYCP2

chr20:58440443

chr20:30253889

ENST00000371001

655_660

1505

1531.0

Compositional bias

Note=Poly-Ser

Tgene

BCL2L1

chr20:58440443

chr20:30253889

ENST00000376055

129_148

125

171.0

Motif

Note=BH1

Tgene

BCL2L1

chr20:58440443

chr20:30253889

ENST00000376055

180_195

125

171.0

Motif

Note=BH2

Tgene

BCL2L1

chr20:58440443

chr20:30253889

ENST00000307677

210_226

188

234.0

Transmembrane

Helical

Tgene

BCL2L1

chr20:58440443

chr20:30253889

ENST00000376055

210_226

125

171.0

Transmembrane

Helical

Tgene

BCL2L1

chr20:58440443

chr20:30253889

ENST00000376062

210_226

188

234.0

Transmembrane

Helical

Tgene

BCL2L1

chr20:58440443

chr20:30253889

ENST00000420653

210_226

188

234.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

BCL2L1

chr20:58440443

chr20:30253889

ENST00000307677

129_148

188

234.0

Motif

Note=BH1

Tgene

BCL2L1

chr20:58440443

chr20:30253889

ENST00000307677

180_195

188

234.0

Motif

Note=BH2

Tgene

BCL2L1

chr20:58440443

chr20:30253889

ENST00000307677

4_24

188

234.0

Motif

Note=BH4

Tgene

BCL2L1

chr20:58440443

chr20:30253889

ENST00000307677

86_100

188

234.0

Motif

Note=BH3

Tgene

BCL2L1

chr20:58440443

chr20:30253889

ENST00000376055

4_24

125

171.0

Motif

Note=BH4

Tgene

BCL2L1

chr20:58440443

chr20:30253889

ENST00000376055

86_100

125

171.0

Motif

Note=BH3

Tgene

BCL2L1

chr20:58440443

chr20:30253889

ENST00000376062

129_148

188

234.0

Motif

Note=BH1

Tgene

BCL2L1

chr20:58440443

chr20:30253889

ENST00000376062

180_195

188

234.0

Motif

Note=BH2

Tgene

BCL2L1

chr20:58440443

chr20:30253889

ENST00000376062

4_24

188

234.0

Motif

Note=BH4

Tgene

BCL2L1

chr20:58440443

chr20:30253889

ENST00000376062

86_100

188

234.0

Motif

Note=BH3

Tgene

BCL2L1

chr20:58440443

chr20:30253889

ENST00000420653

129_148

188

234.0

Motif

Note=BH1

Tgene

BCL2L1

chr20:58440443

chr20:30253889

ENST00000420653

180_195

188

234.0

Motif

Note=BH2

Tgene

BCL2L1

chr20:58440443

chr20:30253889

ENST00000420653

4_24

188

234.0

Motif

Note=BH4

Tgene

BCL2L1

chr20:58440443

chr20:30253889

ENST00000420653

86_100

188

234.0

Motif

Note=BH3

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Fusion Gene Sequence for SYCP2-BCL2L1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>88332_88332_1_SYCP2-BCL2L1_SYCP2_chr20_58440443_ENST00000357552_BCL2L1_chr20_30253889_ENST00000376062_length(transcript)=6376nt_BP=4741nt
TGCGGCGGTCCCTGAGGCGCAGAGTTGCGACGCTCGGCGGCATAGGGGGCGGCTCCACCGACACTACGCGGACGCCTCCTGCCGCAGATA
CACAATCATCATCTTACTAGTTCTCTGTGTTGCTCGCTAACCAGTCCCCCAGTTCAGTAGACTGGAGCCCAGAGCCTGCTTACTTGTCAG
GTGTTTATTTTGTCTTGCTTTTTTTTTTTTTTTAAATGAAGTCAAAATGCCAATAAGACCAGATCTCCAGCAGTTGGAAAAATGCATTGA
TGATGCTTTAAGAAAAAATGATTTCAAACCTTTGAAAACACTTTTGCAAATTGATATTTGTGAAGATGTGAAGATTAAATGCAGCAAACA
GTTTTTCCACAAGGTGGACAACCTTATATGCAGGGAACTTAATAAAGAGGATATCCACAATGTTTCAGCCATTTTGGTTTCTGTTGGAAG
ATGTGGCAAAAATATCAGTGTATTGGGGCAAGCTGGACTTCTAACGATGATAAAACAAGGACTAATACAAAAGATGGTTGCCTGGTTTGA
AAAATCCAAGGACATTATTCAGAGTCAAGGAAATTCAAAAGATGAAGCTGTTCTAAATATGATAGAAGACTTAGTTGATCTTCTGCTGGT
CATACATGATGTCAGTGATGAAGGTAAAAAACAAGTAGTGGAAAGTTTCGTACCTCGCATTTGTTCCCTGGTTATTGACTCAAGAGTGAA
TATTTGTATTCAGCAAGAGATTATAAAAAAAATGAATGCTATGCTTGACAAAATGCCTCAAGATGCCCGGAAAATACTCTCTAACCAAGA
AATGTTAATTCTCATGAGTAGTATGGGAGAAAGGATTTTAGATGCTGGAGATTATGACTTACAGGTAGGCATTGTAGAAGCTTTGTGTAG
AATGACCACAGAAAAACAAAGACAAGAACTGGCACATCAGTGGTTTTCAATGGATTTTATTGCTAAGGCATTTAAAAGAATTAAGGACTC
TGAATTTGAAACAGATTGCAGGATATTTCTCAACCTTGTAAATGGCATGCTTGGAGACAAAAGAAGGGTCTTTACATTTCCTTGTTTATC
AGCATTTCTTGATAAATATGAGCTGCAAATACCATCAGATGAAAAACTTGAGGAATTTTGGATTGATTTTAATCTTGGGAGTCAGACTCT
CTCATTCTACATTGCTGGAGATAATGATGATCATCAATGGGAAGCAGTTACTGTGCCAGAGGAAAAAGTACAAATATACAGCATTGAAGT
GAGAGAATCAAAGAAGCTACTGACAATAATTCTGAAAAATACAGTAAAAATTAGCAAAAGAGAAGGGAAAGAATTGCTTTTGTATTTTGA
CGCATCACTAGAAATCACTAATGTAACTCAAAAAATTTTTGGTGCAACTAAACATAGGGAATCTATCAGAAAACAAGGTATTTCAGTTGC
CAAAACGTCGCTGCATATACTTTTTGACGCAAGTGGATCACAGATTCTAGTGCCAGAAAGTCAAATCTCACCAGTCGGAGAAGAGCTCGT
TAGTTTAAAGGAAAAATCAAAGTCCCCAAAGGAATTTGCTAAACCTTCAAAATATATCAAAAACAGTGACAAAGGGAATAGAAATAATAG
TCAGCTTGAGAAAACTACTCCTAGCAAAAGAAAAATGTCTGAAGCATCAATGATTGTTTCTGGTGCAGATAGATACACTATGAGAAGTCC
AGTGCTTTTCAGCAACACATCAATACCACCACGAAGAAGAAGAATTAAACCACCACTGCAAATGACGAGCTCTGCAGAGAAACCTAGTGT
TTCTCAAACATCAGAAAATAGAGTGGATAATGCTGCATCACTGAAATCTAGATCATCAGAAGGAAGACATAGAAGAGATAATATAGACAA
ACATATCAAAACTGCTAAGTGTGTAGAAAACACAGAAAATAAGAATGTTGAATTCCCAAACCAAAATTTTAGTGAACTCCAGGATGTTAT
ACCAGATTCACAGGCAGCGGAAAAAAGAGATCATACTATATTACCTGGTGTTTTAGACAACATCTGTGGAAATAAAATACACAGCAAATG
GGCATGTTGGACACCTGTAACAAACATTGAACTATGTAATAACCAAAGAGCAAGTACTTCGTCAGGAGACACATTGAATCAAGATATTGT
TATAAATAAAAAACTTACTAAACAAAAATCATCCTCTTCAATATCTGATCATAATTCTGAAGGAACAGGAAAAGTGAAATATAAGAAAGA
ACAAACCGACCATATCAAAATAGATAAAGCAGAAGTAGAAGTTTGCAAGAAACACAATCAGCAACAAAATCATCCTAAATATTCAGGGCA
GAAAAATACTGAAAATGCCAAGCAGAGTGATTGGCCTGTTGAATCTGAAACTACTTTTAAATCGGTTCTCCTAAATAAGACAATTGAAGA
ATCGCTGATATATAGGAAGAAATACATATTGTCAAAAGATGTGAATACTGCTACTTGCGATAAAAATCCATCTGCTAGCAAAAATGTGCA
AAGTCATAGAAAAGCAGAGAAAGAATTGACTTCTGAGCTTAATTCCTGGGATTCGAAACAAAAAAAAATGAGAGAAAAGTCAAAAGGGAA
AGAATTTACCAATGTAGCAGAATCCTTGATAAGCCAAATCAATAAAAGATACAAAACAAAAGATGACATCAAGTCTACAAGAAAATTAAA
GGAGTCTTTGATTAACAGTGGTTTTTCAAACAAACCTGTTGTACAACTCAGTAAGGAAAAAGTTCAGAAAAAAAGCTACAGAAAACTGAA
GACTACCTTTGTTAATGTTACTTCTGAATGCCCAGTGAATGATGTTTACAATTTTAATTTGAATGGAGCTGATGACCCTATCATAAAACT
TGGAATCCAAGAGTTTCAAGCTACAGCTAAAGAAGCTTGTGCGGATAGGTCAATTAGATTGGTAGGTCCAAGGAATCATGATGAACTTAA
ATCTTCTGTCAAAACAAAAGATAAAAAAATTATAACAAATCATCAAAAGAAAAATCTGTTTAGTGATACTGAAACAGAGTACAGATGTGA
TGACAGCAAGACTGATATTAGCTGGCTAAGAGAACCGAAATCAAAACCACAGCTAATAGACTATAGCAGAAATAAAAATGTGAAGAATCA
TAAAAGTGGAAAATCAAGATCATCCTTGGAAAAGGGACAGCCAAGCTCTAAAATGACACCCAGTAAAAATATCACAAAAAAGATGGACAA
GACAATTCCGGAAGGAAGAATCAGACTTCCACGAAAAGCAACCAAAACAAAAAAAAACTATAAAGATCTCTCAAATTCAGAATCAGAGTG
TGAACAAGAATTTTCACATTCATTTAAAGAGAACATACCAGTAAAGGAGGAGAATATCCATTCCAGAATGAAAACGGTAAAGCTACCAAA
GAAACAACAGAAAGTCTTCTGTGCTGAAACAGAAAAGGAACTATCAAAACAATGGAAAAACTCATCTCTACTAAAAGATGCTATACGAGA
TAATTGCCTTGACTTATCTCCCAGATCTTTATCTGGCAGTCCATCATCTATAGAAGTAACGAGATGTATAGAGAAAATAACAGAAAAGGA
TTTTACTCAGGATTATGACTGCATAACAAAATCTATATCACCTTATCCAAAAACTTCATCACTTGAATCCTTAAATAGTAACAGTGGAGT
TGGAGGTACAATAAAGTCACCCAAAAACAATGAGAAAAACTTCCTGTGTGCAAGTGAAAGTTGTTCACCAATTCCACGACCACTGTTTTT
GCCCAGACATACTCCAACTAAGAGTAATACTATTGTAAATAGAAAAAAAATAAGTTCTCTGGTACTTACACAAGAAACACAAAACAGTAA
CAGCTATTCAGATGTAAGCAGTTATAGTTCAGAAGAACGGTTTATGGAAATTGAATCTCCACATATCAATGAAAATTATATACAAAGCAA
AAGAGAGGAAAGTCATTTAGCATCTTCATTATCCAAGTCTAGTGAAGGAAGAGAGAAAACGTGGTTTGACATGCCCTGTGATGCTACTCA
TGTATCAGGCCCCACCCAACATCTTAGTCGCAAAAGAATATATATAGAAGATAATCTAAGTAATTCCAATGAAGTAGAAATGGAAGAGAA
AGGAGAAAGGAGAGCAAACTTGCTTCCCAAAAAACTGTGTAAAATTGAAGATGCAGATCATCATATCCACAAAATGTCTGAAAGTGTATC
TTCATTATCAACAAATGACTTTTCTATTCCTTGGGAGACCTGGCAAAATGAATTTGCAGGGATAGAGATGACTTATGAGACTTACGAGAG
GCTCAATTCAGAATTTAAGAGAAGGAATAATATCCGACATAAAATGTTGAGTTATTTTACTACGCAGTCTTGGAAAACAGCTCAGCAACA
TCTGAGAACAATGAATCATCAAAGTCAGGACTCTAGGATTAAAAAACTTGATAAATTCCAATTCATTATCATAGAGGAGCTGGAGAATTT
TGAAAAAGATTCACAGTCTTTAAAAGATTTGGAAAAGGAATTTGTGGACTTTTGGGAAAAGATATTTCAGAAGTTCAGTGCATATCAAAA
AAGCGAACAACAGAGGCTTCATCTTTTGAAAACTTCATTGGCTAAAAGTGTCTTCTGTAATACTGATAGTGAAGAAACTGTTTTTACATC
CGAGATGTGTTTGATGAAAGAAGATATGAAAGTGCTGCAAGACAGGCTTCTTAAGGACATGGATACTTTTGTGGAACTCTATGGGAACAA
TGCAGCAGCCGAGAGCCGAAAGGGCCAGGAACGCTTCAACCGCTGGTTCCTGACGGGCATGACTGTGGCCGGCGTGGTTCTGCTGGGCTC
ACTCTTCAGTCGGAAATGACCAGACACTGACCATCCACTCTACCCTCCCACCCCCTTCTCTGCTCCACCACATCCTCCGTCCAGCCGCCA
TTGCCACCAGGAGAACCACTACATGCAGCCCATGCCCACCTGCCCATCACAGGGTTGGGCCCAGATCTGGTCCCTTGCAGCTAGTTTTCT
AGAATTTATCACACTTCTGTGAGACCCCCACACCTCAGTTCCCTTGGCCTCAGAATTCACAAAATTTCCACAAAATCTGTCCAAAGGAGG
CTGGCAGGTATGGAAGGGTTTGTGGCTGGGGGCAGGAGGGCCCTACCTGATTGGTGCAACCCTTACCCCTTAGCCTCCCTGAAAATGTTT
TTCTGCCAGGGAGCTTGAAAGTTTTCAGAACCTCTTCCCCAGAAAGGAGACTAGATTGCCTTTGTTTTGATGTTTGTGGCCTCAGAATTG
ATCATTTTCCCCCCACTCTCCCCACACTAACCTGGGTTCCCTTTCCTTCCATCCCTACCCCCTAAGAGCCATTTAGGGGCCACTTTTGAC
TAGGGATTCAGGCTGCTTGGGATAAAGATGCAAGGACCAGGACTCCCTCCTCACCTCTGGACTGGCTAGAGTCCTCACTCCCAGTCCAAA
TGTCCTCCAGAAGCCTCTGGCTAGAGGCCAGCCCCACCCAGGAGGGAGGGGGCTATAGCTACAGGAAGCACCCCATGCCAAAGCTAGGGT
GGCCCTTGCAGTTCAGCACCACCCTAGTCCCTTCCCCTCCCTGGCTCCCATGACCATACTGAGGGACCAACTGGGCCCAAGACAGATGCC
CCAGAGCTGTTTATGGCCTCAGCTGCCTCACTTCCTACAAGAGCAGCCTGTGGCATCTTTGCCTTGGGCTGCTCCTCATGGTGGGTTCAG
GGGACTCAGCCCTGAGGTGAAAGGGAGCTATCAGGAACAGCTATGGGAGCCCCAGGGTCTTCCCTACCTCAGGCAGGAAGGGCAGGAAGG
AGAGCCTGCTGCATGGGGTGGGGTAGGGCTGACTAGAAGGGCCAGTCCTGCCTGGCCAGGCAGATCTGTGCCCCATGCCTGTCCAGCCTG
GGCAGCCAGGCTGCCAAGGCCAGAGTGGCCTGGCCAGGAGCTCTTCAGGCCTCCCTCTCTCTTCTGCTCCACCCTTGGCCTGTCTCATCC
CCAGGGGTCCCAGCCACCCCGGGCTCTCTGCTGTACATATTTGAGACTAGTTTTTATTCCTTGTGAAGATGATATACTATTTTTGTTAAG
CGTGTCTGTATTTATGTGTGAGGAGCTGCTGGCTTGCAGTGCGCGTGCACGTGGAGAGCTGGTGCCCGGAGATTGGACGGCCTGATGCTC
CCTCCCCTGCCCTGGTCCAGGGAAGCTGGCCGAGGGTCCTGGCTCCTGAGGGGCATCTGCCCCTCCCCCAACCCCCACCCCACACTTGTT

>88332_88332_1_SYCP2-BCL2L1_SYCP2_chr20_58440443_ENST00000357552_BCL2L1_chr20_30253889_ENST00000376062_length(amino acids)=1575AA_BP=1530
MEPRACLLVRCLFCLAFFFFLNEVKMPIRPDLQQLEKCIDDALRKNDFKPLKTLLQIDICEDVKIKCSKQFFHKVDNLICRELNKEDIHN
VSAILVSVGRCGKNISVLGQAGLLTMIKQGLIQKMVAWFEKSKDIIQSQGNSKDEAVLNMIEDLVDLLLVIHDVSDEGKKQVVESFVPRI
CSLVIDSRVNICIQQEIIKKMNAMLDKMPQDARKILSNQEMLILMSSMGERILDAGDYDLQVGIVEALCRMTTEKQRQELAHQWFSMDFI
AKAFKRIKDSEFETDCRIFLNLVNGMLGDKRRVFTFPCLSAFLDKYELQIPSDEKLEEFWIDFNLGSQTLSFYIAGDNDDHQWEAVTVPE
EKVQIYSIEVRESKKLLTIILKNTVKISKREGKELLLYFDASLEITNVTQKIFGATKHRESIRKQGISVAKTSLHILFDASGSQILVPES
QISPVGEELVSLKEKSKSPKEFAKPSKYIKNSDKGNRNNSQLEKTTPSKRKMSEASMIVSGADRYTMRSPVLFSNTSIPPRRRRIKPPLQ
MTSSAEKPSVSQTSENRVDNAASLKSRSSEGRHRRDNIDKHIKTAKCVENTENKNVEFPNQNFSELQDVIPDSQAAEKRDHTILPGVLDN
ICGNKIHSKWACWTPVTNIELCNNQRASTSSGDTLNQDIVINKKLTKQKSSSSISDHNSEGTGKVKYKKEQTDHIKIDKAEVEVCKKHNQ
QQNHPKYSGQKNTENAKQSDWPVESETTFKSVLLNKTIEESLIYRKKYILSKDVNTATCDKNPSASKNVQSHRKAEKELTSELNSWDSKQ
KKMREKSKGKEFTNVAESLISQINKRYKTKDDIKSTRKLKESLINSGFSNKPVVQLSKEKVQKKSYRKLKTTFVNVTSECPVNDVYNFNL
NGADDPIIKLGIQEFQATAKEACADRSIRLVGPRNHDELKSSVKTKDKKIITNHQKKNLFSDTETEYRCDDSKTDISWLREPKSKPQLID
YSRNKNVKNHKSGKSRSSLEKGQPSSKMTPSKNITKKMDKTIPEGRIRLPRKATKTKKNYKDLSNSESECEQEFSHSFKENIPVKEENIH
SRMKTVKLPKKQQKVFCAETEKELSKQWKNSSLLKDAIRDNCLDLSPRSLSGSPSSIEVTRCIEKITEKDFTQDYDCITKSISPYPKTSS
LESLNSNSGVGGTIKSPKNNEKNFLCASESCSPIPRPLFLPRHTPTKSNTIVNRKKISSLVLTQETQNSNSYSDVSSYSSEERFMEIESP
HINENYIQSKREESHLASSLSKSSEGREKTWFDMPCDATHVSGPTQHLSRKRIYIEDNLSNSNEVEMEEKGERRANLLPKKLCKIEDADH
HIHKMSESVSSLSTNDFSIPWETWQNEFAGIEMTYETYERLNSEFKRRNNIRHKMLSYFTTQSWKTAQQHLRTMNHQSQDSRIKKLDKFQ
FIIIEELENFEKDSQSLKDLEKEFVDFWEKIFQKFSAYQKSEQQRLHLLKTSLAKSVFCNTDSEETVFTSEMCLMKEDMKVLQDRLLKDM

--------------------------------------------------------------
>88332_88332_2_SYCP2-BCL2L1_SYCP2_chr20_58440443_ENST00000371001_BCL2L1_chr20_30253889_ENST00000376055_length(transcript)=6289nt_BP=4654nt
ATACACAATCATCATCTTACTAGTTCTCTGTGTTGCTCGCTAACCAGTCCCCCAGTTCAGTAGACTGGAGCCCAGAGCCTGCTTACTTGT
CAGGTGTTTATTTTGTCTTGCTTTTTTTTTTTTTTTAAATGAAGTCAAAATGCCAATAAGACCAGATCTCCAGCAGTTGGAAAAATGCAT
TGATGATGCTTTAAGAAAAAATGATTTCAAACCTTTGAAAACACTTTTGCAAATTGATATTTGTGAAGATGTGAAGATTAAATGCAGCAA
ACAGTTTTTCCACAAGGTGGACAACCTTATATGCAGGGAACTTAATAAAGAGGATATCCACAATGTTTCAGCCATTTTGGTTTCTGTTGG
AAGATGTGGCAAAAATATCAGTGTATTGGGGCAAGCTGGACTTCTAACGATGATAAAACAAGGACTAATACAAAAGATGGTTGCCTGGTT
TGAAAAATCCAAGGACATTATTCAGAGTCAAGGAAATTCAAAAGATGAAGCTGTTCTAAATATGATAGAAGACTTAGTTGATCTTCTGCT
GGTCATACATGATGTCAGTGATGAAGGTAAAAAACAAGTAGTGGAAAGTTTCGTACCTCGCATTTGTTCCCTGGTTATTGACTCAAGAGT
GAATATTTGTATTCAGCAAGAGATTATAAAAAAAATGAATGCTATGCTTGACAAAATGCCTCAAGATGCCCGGAAAATACTCTCTAACCA
AGAAATGTTAATTCTCATGAGTAGTATGGGAGAAAGGATTTTAGATGCTGGAGATTATGACTTACAGGTAGGCATTGTAGAAGCTTTGTG
TAGAATGACCACAGAAAAACAAAGACAAGAACTGGCACATCAGTGGTTTTCAATGGATTTTATTGCTAAGGCATTTAAAAGAATTAAGGA
CTCTGAATTTGAAACAGATTGCAGGATATTTCTCAACCTTGTAAATGGCATGCTTGGAGACAAAAGAAGGGTCTTTACATTTCCTTGTTT
ATCAGCATTTCTTGATAAATATGAGCTGCAAATACCATCAGATGAAAAACTTGAGGAATTTTGGATTGATTTTAATCTTGGGAGTCAGAC
TCTCTCATTCTACATTGCTGGAGATAATGATGATCATCAATGGGAAGCAGTTACTGTGCCAGAGGAAAAAGTACAAATATACAGCATTGA
AGTGAGAGAATCAAAGAAGCTACTGACAATAATTCTGAAAAATACAGTAAAAATTAGCAAAAGAGAAGGGAAAGAATTGCTTTTGTATTT
TGACGCATCACTAGAAATCACTAATGTAACTCAAAAAATTTTTGGTGCAACTAAACATAGGGAATCTATCAGAAAACAAGGTATTTCAGT
TGCCAAAACGTCGCTGCATATACTTTTTGACGCAAGTGGATCACAGATTCTAGTGCCAGAAAGTCAAATCTCACCAGTCGGAGAAGAGCT
CGTTAGTTTAAAGGAAAAATCAAAGTCCCCAAAGGAATTTGCTAAACCTTCAAAATATATCAAAAACAGTGACAAAGGGAATAGAAATAA
TAGTCAGCTTGAGAAAACTACTCCTAGCAAAAGAAAAATGTCTGAAGCATCAATGATTGTTTCTGGTGCAGATAGATACACTATGAGAAG
TCCAGTGCTTTTCAGCAACACATCAATACCACCACGAAGAAGAAGAATTAAACCACCACTGCAAATGACGAGCTCTGCAGAGAAACCTAG
TGTTTCTCAAACATCAGAAAATAGAGTGGATAATGCTGCATCACTGAAATCTAGATCATCAGAAGGAAGACATAGAAGAGATAATATAGA
CAAACATATCAAAACTGCTAAGTGTGTAGAAAACACAGAAAATAAGAATGTTGAATTCCCAAACCAAAATTTTAGTGAACTCCAGGATGT
TATACCAGATTCACAGGCAGCGGAAAAAAGAGATCATACTATATTACCTGGTGTTTTAGACAACATCTGTGGAAATAAAATACACAGCAA
ATGGGCATGTTGGACACCTGTAACAAACATTGAACTATGTAATAACCAAAGAGCAAGTACTTCGTCAGGAGACACATTGAATCAAGATAT
TGTTATAAATAAAAAACTTACTAAACAAAAATCATCCTCTTCAATATCTGATCATAATTCTGAAGGAACAGGAAAAGTGAAATATAAGAA
AGAACAAACCGACCATATCAAAATAGATAAAGCAGAAGTAGAAGTTTGCAAGAAACACAATCAGCAACAAAATCATCCTAAATATTCAGG
GCAGAAAAATACTGAAAATGCCAAGCAGAGTGATTGGCCTGTTGAATCTGAAACTACTTTTAAATCGGTTCTCCTAAATAAGACAATTGA
AGAATCGCTGATATATAGGAAGAAATACATATTGTCAAAAGATGTGAATACTGCTACTTGCGATAAAAATCCATCTGCTAGCAAAAATGT
GCAAAGTCATAGAAAAGCAGAGAAAGAATTGACTTCTGAGCTTAATTCCTGGGATTCGAAACAAAAAAAAATGAGAGAAAAGTCAAAAGG
GAAAGAATTTACCAATGTAGCAGAATCCTTGATAAGCCAAATCAATAAAAGATACAAAACAAAAGATGACATCAAGTCTACAAGAAAATT
AAAGGAGTCTTTGATTAACAGTGGTTTTTCAAACAAACCTGTTGTACAACTCAGTAAGGAAAAAGTTCAGAAAAAAAGCTACAGAAAACT
GAAGACTACCTTTGTTAATGTTACTTCTGAATGCCCAGTGAATGATGTTTACAATTTTAATTTGAATGGAGCTGATGACCCTATCATAAA
ACTTGGAATCCAAGAGTTTCAAGCTACAGCTAAAGAAGCTTGTGCGGATAGGTCAATTAGATTGGTAGGTCCAAGGAATCATGATGAACT
TAAATCTTCTGTCAAAACAAAAGATAAAAAAATTATAACAAATCATCAAAAGAAAAATCTGTTTAGTGATACTGAAACAGAGTACAGATG
TGATGACAGCAAGACTGATATTAGCTGGCTAAGAGAACCGAAATCAAAACCACAGCTAATAGACTATAGCAGAAATAAAAATGTGAAGAA
TCATAAAAGTGGAAAATCAAGATCATCCTTGGAAAAGGGACAGCCAAGCTCTAAAATGACACCCAGTAAAAATATCACAAAAAAGATGGA
CAAGACAATTCCGGAAGGAAGAATCAGACTTCCACGAAAAGCAACCAAAACAAAAAAAAACTATAAAGATCTCTCAAATTCAGAATCAGA
GTGTGAACAAGAATTTTCACATTCATTTAAAGAGAACATACCAGTAAAGGAGGAGAATATCCATTCCAGAATGAAAACGGTAAAGCTACC
AAAGAAACAACAGAAAGTCTTCTGTGCTGAAACAGAAAAGGAACTATCAAAACAATGGAAAAACTCATCTCTACTAAAAGATGCTATACG
AGATAATTGCCTTGACTTATCTCCCAGATCTTTATCTGGCAGTCCATCATCTATAGAAGTAACGAGATGTATAGAGAAAATAACAGAAAA
GGATTTTACTCAGGATTATGACTGCATAACAAAATCTATATCACCTTATCCAAAAACTTCATCACTTGAATCCTTAAATAGTAACAGTGG
AGTTGGAGGTACAATAAAGTCACCCAAAAACAATGAGAAAAACTTCCTGTGTGCAAGTGAAAGTTGTTCACCAATTCCACGACCACTGTT
TTTGCCCAGACATACTCCAACTAAGAGTAATACTATTGTAAATAGAAAAAAAATAAGTTCTCTGGTACTTACACAAGAAACACAAAACAG
TAACAGCTATTCAGATGTAAGCAGTTATAGTTCAGAAGAACGGTTTATGGAAATTGAATCTCCACATATCAATGAAAATTATATACAAAG
CAAAAGAGAGGAAAGTCATTTAGCATCTTCATTATCCAAGTCTAGTGAAGGAAGAGAGAAAACGTGGTTTGACATGCCCTGTGATGCTAC
TCATGTATCAGGCCCCACCCAACATCTTAGTCGCAAAAGAATATATATAGAAGATAATCTAAGTAATTCCAATGAAGTAGAAATGGAAGA
GAAAGGAGAAAGGAGAGCAAACTTGCTTCCCAAAAAACTGTGTAAAATTGAAGATGCAGATCATCATATCCACAAAATGTCTGAAAGTGT
ATCTTCATTATCAACAAATGACTTTTCTATTCCTTGGGAGACCTGGCAAAATGAATTTGCAGGGATAGAGATGACTTATGAGACTTACGA
GAGGCTCAATTCAGAATTTAAGAGAAGGAATAATATCCGACATAAAATGTTGAGTTATTTTACTACGCAGTCTTGGAAAACAGCTCAGCA
ACATCTGAGAACAATGAATCATCAAAGTCAGGACTCTAGGATTAAAAAACTTGATAAATTCCAATTCATTATCATAGAGGAGCTGGAGAA
TTTTGAAAAAGATTCACAGTCTTTAAAAGATTTGGAAAAGGAATTTGTGGACTTTTGGGAAAAGATATTTCAGAAGTTCAGTGCATATCA
AAAAAGCGAACAACAGAGGCTTCATCTTTTGAAAACTTCATTGGCTAAAAGTGTCTTCTGTAATACTGATAGTGAAGAAACTGTTTTTAC
ATCCGAGATGTGTTTGATGAAAGAAGATATGAAAGTGCTGCAAGACAGGCTTCTTAAGGACATGGATACTTTTGTGGAACTCTATGGGAA
CAATGCAGCAGCCGAGAGCCGAAAGGGCCAGGAACGCTTCAACCGCTGGTTCCTGACGGGCATGACTGTGGCCGGCGTGGTTCTGCTGGG
CTCACTCTTCAGTCGGAAATGACCAGACACTGACCATCCACTCTACCCTCCCACCCCCTTCTCTGCTCCACCACATCCTCCGTCCAGCCG
CCATTGCCACCAGGAGAACCACTACATGCAGCCCATGCCCACCTGCCCATCACAGGGTTGGGCCCAGATCTGGTCCCTTGCAGCTAGTTT
TCTAGAATTTATCACACTTCTGTGAGACCCCCACACCTCAGTTCCCTTGGCCTCAGAATTCACAAAATTTCCACAAAATCTGTCCAAAGG
AGGCTGGCAGGTATGGAAGGGTTTGTGGCTGGGGGCAGGAGGGCCCTACCTGATTGGTGCAACCCTTACCCCTTAGCCTCCCTGAAAATG
TTTTTCTGCCAGGGAGCTTGAAAGTTTTCAGAACCTCTTCCCCAGAAAGGAGACTAGATTGCCTTTGTTTTGATGTTTGTGGCCTCAGAA
TTGATCATTTTCCCCCCACTCTCCCCACACTAACCTGGGTTCCCTTTCCTTCCATCCCTACCCCCTAAGAGCCATTTAGGGGCCACTTTT
GACTAGGGATTCAGGCTGCTTGGGATAAAGATGCAAGGACCAGGACTCCCTCCTCACCTCTGGACTGGCTAGAGTCCTCACTCCCAGTCC
AAATGTCCTCCAGAAGCCTCTGGCTAGAGGCCAGCCCCACCCAGGAGGGAGGGGGCTATAGCTACAGGAAGCACCCCATGCCAAAGCTAG
GGTGGCCCTTGCAGTTCAGCACCACCCTAGTCCCTTCCCCTCCCTGGCTCCCATGACCATACTGAGGGACCAACTGGGCCCAAGACAGAT
GCCCCAGAGCTGTTTATGGCCTCAGCTGCCTCACTTCCTACAAGAGCAGCCTGTGGCATCTTTGCCTTGGGCTGCTCCTCATGGTGGGTT
CAGGGGACTCAGCCCTGAGGTGAAAGGGAGCTATCAGGAACAGCTATGGGAGCCCCAGGGTCTTCCCTACCTCAGGCAGGAAGGGCAGGA
AGGAGAGCCTGCTGCATGGGGTGGGGTAGGGCTGACTAGAAGGGCCAGTCCTGCCTGGCCAGGCAGATCTGTGCCCCATGCCTGTCCAGC
CTGGGCAGCCAGGCTGCCAAGGCCAGAGTGGCCTGGCCAGGAGCTCTTCAGGCCTCCCTCTCTCTTCTGCTCCACCCTTGGCCTGTCTCA
TCCCCAGGGGTCCCAGCCACCCCGGGCTCTCTGCTGTACATATTTGAGACTAGTTTTTATTCCTTGTGAAGATGATATACTATTTTTGTT
AAGCGTGTCTGTATTTATGTGTGAGGAGCTGCTGGCTTGCAGTGCGCGTGCACGTGGAGAGCTGGTGCCCGGAGATTGGACGGCCTGATG
CTCCCTCCCCTGCCCTGGTCCAGGGAAGCTGGCCGAGGGTCCTGGCTCCTGAGGGGCATCTGCCCCTCCCCCAACCCCCACCCCACACTT

>88332_88332_2_SYCP2-BCL2L1_SYCP2_chr20_58440443_ENST00000371001_BCL2L1_chr20_30253889_ENST00000376055_length(amino acids)=1575AA_BP=1530
MEPRACLLVRCLFCLAFFFFLNEVKMPIRPDLQQLEKCIDDALRKNDFKPLKTLLQIDICEDVKIKCSKQFFHKVDNLICRELNKEDIHN
VSAILVSVGRCGKNISVLGQAGLLTMIKQGLIQKMVAWFEKSKDIIQSQGNSKDEAVLNMIEDLVDLLLVIHDVSDEGKKQVVESFVPRI
CSLVIDSRVNICIQQEIIKKMNAMLDKMPQDARKILSNQEMLILMSSMGERILDAGDYDLQVGIVEALCRMTTEKQRQELAHQWFSMDFI
AKAFKRIKDSEFETDCRIFLNLVNGMLGDKRRVFTFPCLSAFLDKYELQIPSDEKLEEFWIDFNLGSQTLSFYIAGDNDDHQWEAVTVPE
EKVQIYSIEVRESKKLLTIILKNTVKISKREGKELLLYFDASLEITNVTQKIFGATKHRESIRKQGISVAKTSLHILFDASGSQILVPES
QISPVGEELVSLKEKSKSPKEFAKPSKYIKNSDKGNRNNSQLEKTTPSKRKMSEASMIVSGADRYTMRSPVLFSNTSIPPRRRRIKPPLQ
MTSSAEKPSVSQTSENRVDNAASLKSRSSEGRHRRDNIDKHIKTAKCVENTENKNVEFPNQNFSELQDVIPDSQAAEKRDHTILPGVLDN
ICGNKIHSKWACWTPVTNIELCNNQRASTSSGDTLNQDIVINKKLTKQKSSSSISDHNSEGTGKVKYKKEQTDHIKIDKAEVEVCKKHNQ
QQNHPKYSGQKNTENAKQSDWPVESETTFKSVLLNKTIEESLIYRKKYILSKDVNTATCDKNPSASKNVQSHRKAEKELTSELNSWDSKQ
KKMREKSKGKEFTNVAESLISQINKRYKTKDDIKSTRKLKESLINSGFSNKPVVQLSKEKVQKKSYRKLKTTFVNVTSECPVNDVYNFNL
NGADDPIIKLGIQEFQATAKEACADRSIRLVGPRNHDELKSSVKTKDKKIITNHQKKNLFSDTETEYRCDDSKTDISWLREPKSKPQLID
YSRNKNVKNHKSGKSRSSLEKGQPSSKMTPSKNITKKMDKTIPEGRIRLPRKATKTKKNYKDLSNSESECEQEFSHSFKENIPVKEENIH
SRMKTVKLPKKQQKVFCAETEKELSKQWKNSSLLKDAIRDNCLDLSPRSLSGSPSSIEVTRCIEKITEKDFTQDYDCITKSISPYPKTSS
LESLNSNSGVGGTIKSPKNNEKNFLCASESCSPIPRPLFLPRHTPTKSNTIVNRKKISSLVLTQETQNSNSYSDVSSYSSEERFMEIESP
HINENYIQSKREESHLASSLSKSSEGREKTWFDMPCDATHVSGPTQHLSRKRIYIEDNLSNSNEVEMEEKGERRANLLPKKLCKIEDADH
HIHKMSESVSSLSTNDFSIPWETWQNEFAGIEMTYETYERLNSEFKRRNNIRHKMLSYFTTQSWKTAQQHLRTMNHQSQDSRIKKLDKFQ
FIIIEELENFEKDSQSLKDLEKEFVDFWEKIFQKFSAYQKSEQQRLHLLKTSLAKSVFCNTDSEETVFTSEMCLMKEDMKVLQDRLLKDM

--------------------------------------------------------------
>88332_88332_3_SYCP2-BCL2L1_SYCP2_chr20_58440443_ENST00000371001_BCL2L1_chr20_30253889_ENST00000420653_length(transcript)=6281nt_BP=4654nt
ATACACAATCATCATCTTACTAGTTCTCTGTGTTGCTCGCTAACCAGTCCCCCAGTTCAGTAGACTGGAGCCCAGAGCCTGCTTACTTGT
CAGGTGTTTATTTTGTCTTGCTTTTTTTTTTTTTTTAAATGAAGTCAAAATGCCAATAAGACCAGATCTCCAGCAGTTGGAAAAATGCAT
TGATGATGCTTTAAGAAAAAATGATTTCAAACCTTTGAAAACACTTTTGCAAATTGATATTTGTGAAGATGTGAAGATTAAATGCAGCAA
ACAGTTTTTCCACAAGGTGGACAACCTTATATGCAGGGAACTTAATAAAGAGGATATCCACAATGTTTCAGCCATTTTGGTTTCTGTTGG
AAGATGTGGCAAAAATATCAGTGTATTGGGGCAAGCTGGACTTCTAACGATGATAAAACAAGGACTAATACAAAAGATGGTTGCCTGGTT
TGAAAAATCCAAGGACATTATTCAGAGTCAAGGAAATTCAAAAGATGAAGCTGTTCTAAATATGATAGAAGACTTAGTTGATCTTCTGCT
GGTCATACATGATGTCAGTGATGAAGGTAAAAAACAAGTAGTGGAAAGTTTCGTACCTCGCATTTGTTCCCTGGTTATTGACTCAAGAGT
GAATATTTGTATTCAGCAAGAGATTATAAAAAAAATGAATGCTATGCTTGACAAAATGCCTCAAGATGCCCGGAAAATACTCTCTAACCA
AGAAATGTTAATTCTCATGAGTAGTATGGGAGAAAGGATTTTAGATGCTGGAGATTATGACTTACAGGTAGGCATTGTAGAAGCTTTGTG
TAGAATGACCACAGAAAAACAAAGACAAGAACTGGCACATCAGTGGTTTTCAATGGATTTTATTGCTAAGGCATTTAAAAGAATTAAGGA
CTCTGAATTTGAAACAGATTGCAGGATATTTCTCAACCTTGTAAATGGCATGCTTGGAGACAAAAGAAGGGTCTTTACATTTCCTTGTTT
ATCAGCATTTCTTGATAAATATGAGCTGCAAATACCATCAGATGAAAAACTTGAGGAATTTTGGATTGATTTTAATCTTGGGAGTCAGAC
TCTCTCATTCTACATTGCTGGAGATAATGATGATCATCAATGGGAAGCAGTTACTGTGCCAGAGGAAAAAGTACAAATATACAGCATTGA
AGTGAGAGAATCAAAGAAGCTACTGACAATAATTCTGAAAAATACAGTAAAAATTAGCAAAAGAGAAGGGAAAGAATTGCTTTTGTATTT
TGACGCATCACTAGAAATCACTAATGTAACTCAAAAAATTTTTGGTGCAACTAAACATAGGGAATCTATCAGAAAACAAGGTATTTCAGT
TGCCAAAACGTCGCTGCATATACTTTTTGACGCAAGTGGATCACAGATTCTAGTGCCAGAAAGTCAAATCTCACCAGTCGGAGAAGAGCT
CGTTAGTTTAAAGGAAAAATCAAAGTCCCCAAAGGAATTTGCTAAACCTTCAAAATATATCAAAAACAGTGACAAAGGGAATAGAAATAA
TAGTCAGCTTGAGAAAACTACTCCTAGCAAAAGAAAAATGTCTGAAGCATCAATGATTGTTTCTGGTGCAGATAGATACACTATGAGAAG
TCCAGTGCTTTTCAGCAACACATCAATACCACCACGAAGAAGAAGAATTAAACCACCACTGCAAATGACGAGCTCTGCAGAGAAACCTAG
TGTTTCTCAAACATCAGAAAATAGAGTGGATAATGCTGCATCACTGAAATCTAGATCATCAGAAGGAAGACATAGAAGAGATAATATAGA
CAAACATATCAAAACTGCTAAGTGTGTAGAAAACACAGAAAATAAGAATGTTGAATTCCCAAACCAAAATTTTAGTGAACTCCAGGATGT
TATACCAGATTCACAGGCAGCGGAAAAAAGAGATCATACTATATTACCTGGTGTTTTAGACAACATCTGTGGAAATAAAATACACAGCAA
ATGGGCATGTTGGACACCTGTAACAAACATTGAACTATGTAATAACCAAAGAGCAAGTACTTCGTCAGGAGACACATTGAATCAAGATAT
TGTTATAAATAAAAAACTTACTAAACAAAAATCATCCTCTTCAATATCTGATCATAATTCTGAAGGAACAGGAAAAGTGAAATATAAGAA
AGAACAAACCGACCATATCAAAATAGATAAAGCAGAAGTAGAAGTTTGCAAGAAACACAATCAGCAACAAAATCATCCTAAATATTCAGG
GCAGAAAAATACTGAAAATGCCAAGCAGAGTGATTGGCCTGTTGAATCTGAAACTACTTTTAAATCGGTTCTCCTAAATAAGACAATTGA
AGAATCGCTGATATATAGGAAGAAATACATATTGTCAAAAGATGTGAATACTGCTACTTGCGATAAAAATCCATCTGCTAGCAAAAATGT
GCAAAGTCATAGAAAAGCAGAGAAAGAATTGACTTCTGAGCTTAATTCCTGGGATTCGAAACAAAAAAAAATGAGAGAAAAGTCAAAAGG
GAAAGAATTTACCAATGTAGCAGAATCCTTGATAAGCCAAATCAATAAAAGATACAAAACAAAAGATGACATCAAGTCTACAAGAAAATT
AAAGGAGTCTTTGATTAACAGTGGTTTTTCAAACAAACCTGTTGTACAACTCAGTAAGGAAAAAGTTCAGAAAAAAAGCTACAGAAAACT
GAAGACTACCTTTGTTAATGTTACTTCTGAATGCCCAGTGAATGATGTTTACAATTTTAATTTGAATGGAGCTGATGACCCTATCATAAA
ACTTGGAATCCAAGAGTTTCAAGCTACAGCTAAAGAAGCTTGTGCGGATAGGTCAATTAGATTGGTAGGTCCAAGGAATCATGATGAACT
TAAATCTTCTGTCAAAACAAAAGATAAAAAAATTATAACAAATCATCAAAAGAAAAATCTGTTTAGTGATACTGAAACAGAGTACAGATG
TGATGACAGCAAGACTGATATTAGCTGGCTAAGAGAACCGAAATCAAAACCACAGCTAATAGACTATAGCAGAAATAAAAATGTGAAGAA
TCATAAAAGTGGAAAATCAAGATCATCCTTGGAAAAGGGACAGCCAAGCTCTAAAATGACACCCAGTAAAAATATCACAAAAAAGATGGA
CAAGACAATTCCGGAAGGAAGAATCAGACTTCCACGAAAAGCAACCAAAACAAAAAAAAACTATAAAGATCTCTCAAATTCAGAATCAGA
GTGTGAACAAGAATTTTCACATTCATTTAAAGAGAACATACCAGTAAAGGAGGAGAATATCCATTCCAGAATGAAAACGGTAAAGCTACC
AAAGAAACAACAGAAAGTCTTCTGTGCTGAAACAGAAAAGGAACTATCAAAACAATGGAAAAACTCATCTCTACTAAAAGATGCTATACG
AGATAATTGCCTTGACTTATCTCCCAGATCTTTATCTGGCAGTCCATCATCTATAGAAGTAACGAGATGTATAGAGAAAATAACAGAAAA
GGATTTTACTCAGGATTATGACTGCATAACAAAATCTATATCACCTTATCCAAAAACTTCATCACTTGAATCCTTAAATAGTAACAGTGG
AGTTGGAGGTACAATAAAGTCACCCAAAAACAATGAGAAAAACTTCCTGTGTGCAAGTGAAAGTTGTTCACCAATTCCACGACCACTGTT
TTTGCCCAGACATACTCCAACTAAGAGTAATACTATTGTAAATAGAAAAAAAATAAGTTCTCTGGTACTTACACAAGAAACACAAAACAG
TAACAGCTATTCAGATGTAAGCAGTTATAGTTCAGAAGAACGGTTTATGGAAATTGAATCTCCACATATCAATGAAAATTATATACAAAG
CAAAAGAGAGGAAAGTCATTTAGCATCTTCATTATCCAAGTCTAGTGAAGGAAGAGAGAAAACGTGGTTTGACATGCCCTGTGATGCTAC
TCATGTATCAGGCCCCACCCAACATCTTAGTCGCAAAAGAATATATATAGAAGATAATCTAAGTAATTCCAATGAAGTAGAAATGGAAGA
GAAAGGAGAAAGGAGAGCAAACTTGCTTCCCAAAAAACTGTGTAAAATTGAAGATGCAGATCATCATATCCACAAAATGTCTGAAAGTGT
ATCTTCATTATCAACAAATGACTTTTCTATTCCTTGGGAGACCTGGCAAAATGAATTTGCAGGGATAGAGATGACTTATGAGACTTACGA
GAGGCTCAATTCAGAATTTAAGAGAAGGAATAATATCCGACATAAAATGTTGAGTTATTTTACTACGCAGTCTTGGAAAACAGCTCAGCA
ACATCTGAGAACAATGAATCATCAAAGTCAGGACTCTAGGATTAAAAAACTTGATAAATTCCAATTCATTATCATAGAGGAGCTGGAGAA
TTTTGAAAAAGATTCACAGTCTTTAAAAGATTTGGAAAAGGAATTTGTGGACTTTTGGGAAAAGATATTTCAGAAGTTCAGTGCATATCA
AAAAAGCGAACAACAGAGGCTTCATCTTTTGAAAACTTCATTGGCTAAAAGTGTCTTCTGTAATACTGATAGTGAAGAAACTGTTTTTAC
ATCCGAGATGTGTTTGATGAAAGAAGATATGAAAGTGCTGCAAGACAGGCTTCTTAAGGACATGGATACTTTTGTGGAACTCTATGGGAA
CAATGCAGCAGCCGAGAGCCGAAAGGGCCAGGAACGCTTCAACCGCTGGTTCCTGACGGGCATGACTGTGGCCGGCGTGGTTCTGCTGGG
CTCACTCTTCAGTCGGAAATGACCAGACACTGACCATCCACTCTACCCTCCCACCCCCTTCTCTGCTCCACCACATCCTCCGTCCAGCCG
CCATTGCCACCAGGAGAACCACTACATGCAGCCCATGCCCACCTGCCCATCACAGGGTTGGGCCCAGATCTGGTCCCTTGCAGCTAGTTT
TCTAGAATTTATCACACTTCTGTGAGACCCCCACACCTCAGTTCCCTTGGCCTCAGAATTCACAAAATTTCCACAAAATCTGTCCAAAGG
AGGCTGGCAGGTATGGAAGGGTTTGTGGCTGGGGGCAGGAGGGCCCTACCTGATTGGTGCAACCCTTACCCCTTAGCCTCCCTGAAAATG
TTTTTCTGCCAGGGAGCTTGAAAGTTTTCAGAACCTCTTCCCCAGAAAGGAGACTAGATTGCCTTTGTTTTGATGTTTGTGGCCTCAGAA
TTGATCATTTTCCCCCCACTCTCCCCACACTAACCTGGGTTCCCTTTCCTTCCATCCCTACCCCCTAAGAGCCATTTAGGGGCCACTTTT
GACTAGGGATTCAGGCTGCTTGGGATAAAGATGCAAGGACCAGGACTCCCTCCTCACCTCTGGACTGGCTAGAGTCCTCACTCCCAGTCC
AAATGTCCTCCAGAAGCCTCTGGCTAGAGGCCAGCCCCACCCAGGAGGGAGGGGGCTATAGCTACAGGAAGCACCCCATGCCAAAGCTAG
GGTGGCCCTTGCAGTTCAGCACCACCCTAGTCCCTTCCCCTCCCTGGCTCCCATGACCATACTGAGGGACCAACTGGGCCCAAGACAGAT
GCCCCAGAGCTGTTTATGGCCTCAGCTGCCTCACTTCCTACAAGAGCAGCCTGTGGCATCTTTGCCTTGGGCTGCTCCTCATGGTGGGTT
CAGGGGACTCAGCCCTGAGGTGAAAGGGAGCTATCAGGAACAGCTATGGGAGCCCCAGGGTCTTCCCTACCTCAGGCAGGAAGGGCAGGA
AGGAGAGCCTGCTGCATGGGGTGGGGTAGGGCTGACTAGAAGGGCCAGTCCTGCCTGGCCAGGCAGATCTGTGCCCCATGCCTGTCCAGC
CTGGGCAGCCAGGCTGCCAAGGCCAGAGTGGCCTGGCCAGGAGCTCTTCAGGCCTCCCTCTCTCTTCTGCTCCACCCTTGGCCTGTCTCA
TCCCCAGGGGTCCCAGCCACCCCGGGCTCTCTGCTGTACATATTTGAGACTAGTTTTTATTCCTTGTGAAGATGATATACTATTTTTGTT
AAGCGTGTCTGTATTTATGTGTGAGGAGCTGCTGGCTTGCAGTGCGCGTGCACGTGGAGAGCTGGTGCCCGGAGATTGGACGGCCTGATG
CTCCCTCCCCTGCCCTGGTCCAGGGAAGCTGGCCGAGGGTCCTGGCTCCTGAGGGGCATCTGCCCCTCCCCCAACCCCCACCCCACACTT

>88332_88332_3_SYCP2-BCL2L1_SYCP2_chr20_58440443_ENST00000371001_BCL2L1_chr20_30253889_ENST00000420653_length(amino acids)=1575AA_BP=1530
MEPRACLLVRCLFCLAFFFFLNEVKMPIRPDLQQLEKCIDDALRKNDFKPLKTLLQIDICEDVKIKCSKQFFHKVDNLICRELNKEDIHN
VSAILVSVGRCGKNISVLGQAGLLTMIKQGLIQKMVAWFEKSKDIIQSQGNSKDEAVLNMIEDLVDLLLVIHDVSDEGKKQVVESFVPRI
CSLVIDSRVNICIQQEIIKKMNAMLDKMPQDARKILSNQEMLILMSSMGERILDAGDYDLQVGIVEALCRMTTEKQRQELAHQWFSMDFI
AKAFKRIKDSEFETDCRIFLNLVNGMLGDKRRVFTFPCLSAFLDKYELQIPSDEKLEEFWIDFNLGSQTLSFYIAGDNDDHQWEAVTVPE
EKVQIYSIEVRESKKLLTIILKNTVKISKREGKELLLYFDASLEITNVTQKIFGATKHRESIRKQGISVAKTSLHILFDASGSQILVPES
QISPVGEELVSLKEKSKSPKEFAKPSKYIKNSDKGNRNNSQLEKTTPSKRKMSEASMIVSGADRYTMRSPVLFSNTSIPPRRRRIKPPLQ
MTSSAEKPSVSQTSENRVDNAASLKSRSSEGRHRRDNIDKHIKTAKCVENTENKNVEFPNQNFSELQDVIPDSQAAEKRDHTILPGVLDN
ICGNKIHSKWACWTPVTNIELCNNQRASTSSGDTLNQDIVINKKLTKQKSSSSISDHNSEGTGKVKYKKEQTDHIKIDKAEVEVCKKHNQ
QQNHPKYSGQKNTENAKQSDWPVESETTFKSVLLNKTIEESLIYRKKYILSKDVNTATCDKNPSASKNVQSHRKAEKELTSELNSWDSKQ
KKMREKSKGKEFTNVAESLISQINKRYKTKDDIKSTRKLKESLINSGFSNKPVVQLSKEKVQKKSYRKLKTTFVNVTSECPVNDVYNFNL
NGADDPIIKLGIQEFQATAKEACADRSIRLVGPRNHDELKSSVKTKDKKIITNHQKKNLFSDTETEYRCDDSKTDISWLREPKSKPQLID
YSRNKNVKNHKSGKSRSSLEKGQPSSKMTPSKNITKKMDKTIPEGRIRLPRKATKTKKNYKDLSNSESECEQEFSHSFKENIPVKEENIH
SRMKTVKLPKKQQKVFCAETEKELSKQWKNSSLLKDAIRDNCLDLSPRSLSGSPSSIEVTRCIEKITEKDFTQDYDCITKSISPYPKTSS
LESLNSNSGVGGTIKSPKNNEKNFLCASESCSPIPRPLFLPRHTPTKSNTIVNRKKISSLVLTQETQNSNSYSDVSSYSSEERFMEIESP
HINENYIQSKREESHLASSLSKSSEGREKTWFDMPCDATHVSGPTQHLSRKRIYIEDNLSNSNEVEMEEKGERRANLLPKKLCKIEDADH
HIHKMSESVSSLSTNDFSIPWETWQNEFAGIEMTYETYERLNSEFKRRNNIRHKMLSYFTTQSWKTAQQHLRTMNHQSQDSRIKKLDKFQ
FIIIEELENFEKDSQSLKDLEKEFVDFWEKIFQKFSAYQKSEQQRLHLLKTSLAKSVFCNTDSEETVFTSEMCLMKEDMKVLQDRLLKDM

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Fusion Gene PPI Analysis for SYCP2-BCL2L1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for SYCP2-BCL2L1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SYCP2-BCL2L1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source