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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SYNE1-MED23 (FusionGDB2 ID:88409)

Fusion Gene Summary for SYNE1-MED23

check button Fusion gene summary
Fusion gene informationFusion gene name: SYNE1-MED23
Fusion gene ID: 88409
HgeneTgene
Gene symbol

SYNE1

MED23

Gene ID

23345

9439

Gene namespectrin repeat containing nuclear envelope protein 1mediator complex subunit 23
Synonyms8B|AMCM|ARCA1|C6orf98|CPG2|EDMD4|KASH1|MYNE1|Nesp1|SCAR8|dJ45H2.2ARC130|CRSP130|CRSP133|CRSP3|DRIP130|MRT18|SUR-2|SUR2
Cytomap

6q25.2

6q23.2

Type of geneprotein-codingprotein-coding
Descriptionnesprin-1CPG2 full lengthKASH domain-containing protein 1enaptinmyocyte nuclear envelope protein 1nesprin 1spectrin repeat containing, nuclear envelope 1synaptic nuclear envelope protein 1synaptic nuclei expressed gene 1mediator of RNA polymerase II transcription subunit 23130 kDa transcriptional co-activator133 kDa transcriptional co-activatoractivator-recruited cofactor 130 kDa componentcofactor required for Sp1 transcriptional activation subunit 3mental retardati
Modification date2020032020200313
UniProtAcc.

Q9ULK4

Ensembl transtripts involved in fusion geneENST00000265368, ENST00000341594, 
ENST00000356820, ENST00000367255, 
ENST00000423061, ENST00000448038, 
ENST00000347037, ENST00000354674, 
ENST00000367248, ENST00000367253, 
ENST00000413186, ENST00000466159, 
ENST00000495090, ENST00000539504, 
ENST00000368053, ENST00000368058, 
ENST00000368060, ENST00000479213, 
ENST00000539158, ENST00000540546, 
ENST00000545957, ENST00000354577, 
ENST00000368068, ENST00000403834, 
Fusion gene scores* DoF score13 X 15 X 6=11704 X 6 X 3=72
# samples 146
** MAII scorelog2(14/1170*10)=-3.0630097975258
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SYNE1 [Title/Abstract] AND MED23 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSYNE1(152497529)-MED23(131924344), # samples:1
Anticipated loss of major functional domain due to fusion event.SYNE1-MED23 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SYNE1-MED23 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
SYNE1-MED23 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSYNE1

GO:0007030

Golgi organization

12808039

HgeneSYNE1

GO:0042692

muscle cell differentiation

11792814

HgeneSYNE1

GO:0090286

cytoskeletal anchoring at nuclear membrane

18396275

HgeneSYNE1

GO:0090292

nuclear matrix anchoring at nuclear membrane

11801724

TgeneMED23

GO:0006355

regulation of transcription, DNA-templated

9989412


check buttonFusion gene breakpoints across SYNE1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MED23 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerERR315469SYNE1chr6

152497529

-MED23chr6

131924344

-


Top

Fusion Gene ORF analysis for SYNE1-MED23

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000265368ENST00000368053SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000265368ENST00000368058SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000265368ENST00000368060SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000265368ENST00000479213SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000265368ENST00000539158SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000265368ENST00000540546SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000265368ENST00000545957SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000341594ENST00000368053SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000341594ENST00000368058SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000341594ENST00000368060SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000341594ENST00000479213SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000341594ENST00000539158SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000341594ENST00000540546SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000341594ENST00000545957SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000356820ENST00000368053SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000356820ENST00000368058SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000356820ENST00000368060SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000356820ENST00000479213SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000356820ENST00000539158SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000356820ENST00000540546SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000356820ENST00000545957SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000367255ENST00000368053SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000367255ENST00000368058SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000367255ENST00000368060SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000367255ENST00000479213SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000367255ENST00000539158SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000367255ENST00000540546SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000367255ENST00000545957SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000423061ENST00000368053SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000423061ENST00000368058SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000423061ENST00000368060SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000423061ENST00000479213SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000423061ENST00000539158SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000423061ENST00000540546SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000423061ENST00000545957SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000448038ENST00000368053SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000448038ENST00000368058SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000448038ENST00000368060SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000448038ENST00000479213SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000448038ENST00000539158SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000448038ENST00000540546SYNE1chr6

152497529

-MED23chr6

131924344

-
5CDS-intronENST00000448038ENST00000545957SYNE1chr6

152497529

-MED23chr6

131924344

-
5UTR-3CDSENST00000347037ENST00000354577SYNE1chr6

152497529

-MED23chr6

131924344

-
5UTR-3CDSENST00000347037ENST00000368068SYNE1chr6

152497529

-MED23chr6

131924344

-
5UTR-3CDSENST00000347037ENST00000403834SYNE1chr6

152497529

-MED23chr6

131924344

-
5UTR-intronENST00000347037ENST00000368053SYNE1chr6

152497529

-MED23chr6

131924344

-
5UTR-intronENST00000347037ENST00000368058SYNE1chr6

152497529

-MED23chr6

131924344

-
5UTR-intronENST00000347037ENST00000368060SYNE1chr6

152497529

-MED23chr6

131924344

-
5UTR-intronENST00000347037ENST00000479213SYNE1chr6

152497529

-MED23chr6

131924344

-
5UTR-intronENST00000347037ENST00000539158SYNE1chr6

152497529

-MED23chr6

131924344

-
5UTR-intronENST00000347037ENST00000540546SYNE1chr6

152497529

-MED23chr6

131924344

-
5UTR-intronENST00000347037ENST00000545957SYNE1chr6

152497529

-MED23chr6

131924344

-
Frame-shiftENST00000265368ENST00000354577SYNE1chr6

152497529

-MED23chr6

131924344

-
Frame-shiftENST00000265368ENST00000368068SYNE1chr6

152497529

-MED23chr6

131924344

-
Frame-shiftENST00000265368ENST00000403834SYNE1chr6

152497529

-MED23chr6

131924344

-
Frame-shiftENST00000341594ENST00000354577SYNE1chr6

152497529

-MED23chr6

131924344

-
Frame-shiftENST00000341594ENST00000368068SYNE1chr6

152497529

-MED23chr6

131924344

-
Frame-shiftENST00000341594ENST00000403834SYNE1chr6

152497529

-MED23chr6

131924344

-
Frame-shiftENST00000356820ENST00000354577SYNE1chr6

152497529

-MED23chr6

131924344

-
Frame-shiftENST00000356820ENST00000368068SYNE1chr6

152497529

-MED23chr6

131924344

-
Frame-shiftENST00000356820ENST00000403834SYNE1chr6

152497529

-MED23chr6

131924344

-
Frame-shiftENST00000367255ENST00000354577SYNE1chr6

152497529

-MED23chr6

131924344

-
Frame-shiftENST00000367255ENST00000368068SYNE1chr6

152497529

-MED23chr6

131924344

-
Frame-shiftENST00000367255ENST00000403834SYNE1chr6

152497529

-MED23chr6

131924344

-
Frame-shiftENST00000448038ENST00000354577SYNE1chr6

152497529

-MED23chr6

131924344

-
Frame-shiftENST00000448038ENST00000368068SYNE1chr6

152497529

-MED23chr6

131924344

-
Frame-shiftENST00000448038ENST00000403834SYNE1chr6

152497529

-MED23chr6

131924344

-
In-frameENST00000423061ENST00000354577SYNE1chr6

152497529

-MED23chr6

131924344

-
In-frameENST00000423061ENST00000368068SYNE1chr6

152497529

-MED23chr6

131924344

-
In-frameENST00000423061ENST00000403834SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-3CDSENST00000354674ENST00000354577SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-3CDSENST00000354674ENST00000368068SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-3CDSENST00000354674ENST00000403834SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-3CDSENST00000367248ENST00000354577SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-3CDSENST00000367248ENST00000368068SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-3CDSENST00000367248ENST00000403834SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-3CDSENST00000367253ENST00000354577SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-3CDSENST00000367253ENST00000368068SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-3CDSENST00000367253ENST00000403834SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-3CDSENST00000413186ENST00000354577SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-3CDSENST00000413186ENST00000368068SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-3CDSENST00000413186ENST00000403834SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-3CDSENST00000466159ENST00000354577SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-3CDSENST00000466159ENST00000368068SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-3CDSENST00000466159ENST00000403834SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-3CDSENST00000495090ENST00000354577SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-3CDSENST00000495090ENST00000368068SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-3CDSENST00000495090ENST00000403834SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-3CDSENST00000539504ENST00000354577SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-3CDSENST00000539504ENST00000368068SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-3CDSENST00000539504ENST00000403834SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000354674ENST00000368053SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000354674ENST00000368058SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000354674ENST00000368060SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000354674ENST00000479213SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000354674ENST00000539158SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000354674ENST00000540546SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000354674ENST00000545957SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000367248ENST00000368053SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000367248ENST00000368058SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000367248ENST00000368060SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000367248ENST00000479213SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000367248ENST00000539158SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000367248ENST00000540546SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000367248ENST00000545957SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000367253ENST00000368053SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000367253ENST00000368058SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000367253ENST00000368060SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000367253ENST00000479213SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000367253ENST00000539158SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000367253ENST00000540546SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000367253ENST00000545957SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000413186ENST00000368053SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000413186ENST00000368058SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000413186ENST00000368060SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000413186ENST00000479213SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000413186ENST00000539158SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000413186ENST00000540546SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000413186ENST00000545957SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000466159ENST00000368053SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000466159ENST00000368058SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000466159ENST00000368060SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000466159ENST00000479213SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000466159ENST00000539158SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000466159ENST00000540546SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000466159ENST00000545957SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000495090ENST00000368053SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000495090ENST00000368058SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000495090ENST00000368060SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000495090ENST00000479213SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000495090ENST00000539158SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000495090ENST00000540546SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000495090ENST00000545957SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000539504ENST00000368053SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000539504ENST00000368058SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000539504ENST00000368060SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000539504ENST00000479213SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000539504ENST00000539158SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000539504ENST00000540546SYNE1chr6

152497529

-MED23chr6

131924344

-
intron-intronENST00000539504ENST00000545957SYNE1chr6

152497529

-MED23chr6

131924344

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000423061SYNE1chr6152497529-ENST00000354577MED23chr6131924344-2650223851437239117824
ENST00000423061SYNE1chr6152497529-ENST00000403834MED23chr6131924344-2714823851437239117824
ENST00000423061SYNE1chr6152497529-ENST00000368068MED23chr6131924344-2714823851437239117824

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000423061ENST00000354577SYNE1chr6152497529-MED23chr6131924344-0.005180610.99481946
ENST00000423061ENST00000403834SYNE1chr6152497529-MED23chr6131924344-0.0045907860.9954092
ENST00000423061ENST00000368068SYNE1chr6152497529-MED23chr6131924344-0.0045907860.9954092

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Fusion Genomic Features for SYNE1-MED23


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SYNE1-MED23


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:152497529/chr6:131924344)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MED23

Q9ULK4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Required for transcriptional activation subsequent to the assembly of the pre-initiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000250, ECO:0000269|PubMed:10353252, ECO:0000269|PubMed:14759369, ECO:0000269|PubMed:16595664}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

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* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-130146178_28378758798.0DomainCalponin-homology (CH) 2
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-13014627_13478758798.0DomainCalponin-homology (CH) 1
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-129146178_28378048750.0DomainCalponin-homology (CH) 2
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-12914627_13478048750.0DomainCalponin-homology (CH) 1
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301461_28978758798.0RegionNote=Actin-binding
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291461_28978048750.0RegionNote=Actin-binding
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301461025_112278758798.0RepeatNote=Spectrin 8
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301461123_124678758798.0RepeatNote=Spectrin 9
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301461247_133578758798.0RepeatNote=Spectrin 10
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301461336_144478758798.0RepeatNote=Spectrin 11
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301461445_155078758798.0RepeatNote=Spectrin 12
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301461551_165378758798.0RepeatNote=Spectrin 13
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301461654_176378758798.0RepeatNote=Spectrin 14
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301461764_187978758798.0RepeatNote=Spectrin 15
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301461880_197678758798.0RepeatNote=Spectrin 16
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301461977_208178758798.0RepeatNote=Spectrin 17
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301462082_219578758798.0RepeatNote=Spectrin 18
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301462196_230378758798.0RepeatNote=Spectrin 19
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301462304_240178758798.0RepeatNote=Spectrin 20
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301462402_251378758798.0RepeatNote=Spectrin 21
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301462514_261978758798.0RepeatNote=Spectrin 22
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301462620_273178758798.0RepeatNote=Spectrin 23
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301462732_283878758798.0RepeatNote=Spectrin 24
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301462839_296278758798.0RepeatNote=Spectrin 25
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301462963_306278758798.0RepeatNote=Spectrin 26
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301463063_317178758798.0RepeatNote=Spectrin 27
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-130146314_39778758798.0RepeatNote=Spectrin 1
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301463172_327578758798.0RepeatNote=Spectrin 28
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301463276_338778758798.0RepeatNote=Spectrin 29
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301463388_349078758798.0RepeatNote=Spectrin 30
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301463491_359378758798.0RepeatNote=Spectrin 31
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301463594_372078758798.0RepeatNote=Spectrin 32
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301463721_381478758798.0RepeatNote=Spectrin 33
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301463815_392078758798.0RepeatNote=Spectrin 34
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301463921_402878758798.0RepeatNote=Spectrin 35
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-130146398_50278758798.0RepeatNote=Spectrin 2
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301464029_413978758798.0RepeatNote=Spectrin 36
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301464140_423578758798.0RepeatNote=Spectrin 37
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301464236_433978758798.0RepeatNote=Spectrin 38
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301464340_445178758798.0RepeatNote=Spectrin 39
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301464452_456078758798.0RepeatNote=Spectrin 40
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301464561_466978758798.0RepeatNote=Spectrin 41
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301464670_477678758798.0RepeatNote=Spectrin 42
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301464777_488278758798.0RepeatNote=Spectrin 43
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301464883_499178758798.0RepeatNote=Spectrin 44
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301464992_509978758798.0RepeatNote=Spectrin 45
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-130146503_60978758798.0RepeatNote=Spectrin 3
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301465100_520978758798.0RepeatNote=Spectrin 46
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301465210_531878758798.0RepeatNote=Spectrin 47
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301465319_542478758798.0RepeatNote=Spectrin 48
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301465425_552278758798.0RepeatNote=Spectrin 49
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301465523_563078758798.0RepeatNote=Spectrin 50
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301465631_573678758798.0RepeatNote=Spectrin 51
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301465737_584278758798.0RepeatNote=Spectrin 52
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301465962_607178758798.0RepeatNote=Spectrin 53
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301466072_617878758798.0RepeatNote=Spectrin 54
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-130146610_70378758798.0RepeatNote=Spectrin 4
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301466374_648578758798.0RepeatNote=Spectrin 55
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301466486_658178758798.0RepeatNote=Spectrin 56
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301466582_669178758798.0RepeatNote=Spectrin 57
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301466692_679578758798.0RepeatNote=Spectrin 58
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301466796_690278758798.0RepeatNote=Spectrin 59
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301466903_702078758798.0RepeatNote=Spectrin 60
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301467021_712878758798.0RepeatNote=Spectrin 61
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-130146704_81578758798.0RepeatNote=Spectrin 5
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301467129_723778758798.0RepeatNote=Spectrin 62
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301467238_735078758798.0RepeatNote=Spectrin 63
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301467351_745478758798.0RepeatNote=Spectrin 64
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301467455_755878758798.0RepeatNote=Spectrin 65
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301467559_767178758798.0RepeatNote=Spectrin 66
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301467672_778378758798.0RepeatNote=Spectrin 67
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-130146816_92378758798.0RepeatNote=Spectrin 6
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-130146924_102478758798.0RepeatNote=Spectrin 7
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291461025_112278048750.0RepeatNote=Spectrin 8
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291461123_124678048750.0RepeatNote=Spectrin 9
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291461247_133578048750.0RepeatNote=Spectrin 10
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291461336_144478048750.0RepeatNote=Spectrin 11
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291461445_155078048750.0RepeatNote=Spectrin 12
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291461551_165378048750.0RepeatNote=Spectrin 13
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291461654_176378048750.0RepeatNote=Spectrin 14
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291461764_187978048750.0RepeatNote=Spectrin 15
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291461880_197678048750.0RepeatNote=Spectrin 16
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291461977_208178048750.0RepeatNote=Spectrin 17
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291462082_219578048750.0RepeatNote=Spectrin 18
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291462196_230378048750.0RepeatNote=Spectrin 19
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291462304_240178048750.0RepeatNote=Spectrin 20
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291462402_251378048750.0RepeatNote=Spectrin 21
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291462514_261978048750.0RepeatNote=Spectrin 22
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291462620_273178048750.0RepeatNote=Spectrin 23
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291462732_283878048750.0RepeatNote=Spectrin 24
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291462839_296278048750.0RepeatNote=Spectrin 25
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291462963_306278048750.0RepeatNote=Spectrin 26
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291463063_317178048750.0RepeatNote=Spectrin 27
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-129146314_39778048750.0RepeatNote=Spectrin 1
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291463172_327578048750.0RepeatNote=Spectrin 28
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291463276_338778048750.0RepeatNote=Spectrin 29
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291463388_349078048750.0RepeatNote=Spectrin 30
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291463491_359378048750.0RepeatNote=Spectrin 31
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291463594_372078048750.0RepeatNote=Spectrin 32
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291463721_381478048750.0RepeatNote=Spectrin 33
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291463815_392078048750.0RepeatNote=Spectrin 34
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291463921_402878048750.0RepeatNote=Spectrin 35
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-129146398_50278048750.0RepeatNote=Spectrin 2
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291464029_413978048750.0RepeatNote=Spectrin 36
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291464140_423578048750.0RepeatNote=Spectrin 37
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291464236_433978048750.0RepeatNote=Spectrin 38
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291464340_445178048750.0RepeatNote=Spectrin 39
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291464452_456078048750.0RepeatNote=Spectrin 40
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291464561_466978048750.0RepeatNote=Spectrin 41
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291464670_477678048750.0RepeatNote=Spectrin 42
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291464777_488278048750.0RepeatNote=Spectrin 43
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291464883_499178048750.0RepeatNote=Spectrin 44
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291464992_509978048750.0RepeatNote=Spectrin 45
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-129146503_60978048750.0RepeatNote=Spectrin 3
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291465100_520978048750.0RepeatNote=Spectrin 46
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291465210_531878048750.0RepeatNote=Spectrin 47
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291465319_542478048750.0RepeatNote=Spectrin 48
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291465425_552278048750.0RepeatNote=Spectrin 49
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291465523_563078048750.0RepeatNote=Spectrin 50
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291465631_573678048750.0RepeatNote=Spectrin 51
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291465737_584278048750.0RepeatNote=Spectrin 52
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291465962_607178048750.0RepeatNote=Spectrin 53
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291466072_617878048750.0RepeatNote=Spectrin 54
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-129146610_70378048750.0RepeatNote=Spectrin 4
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291466374_648578048750.0RepeatNote=Spectrin 55
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291466486_658178048750.0RepeatNote=Spectrin 56
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291466582_669178048750.0RepeatNote=Spectrin 57
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291466692_679578048750.0RepeatNote=Spectrin 58
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291466796_690278048750.0RepeatNote=Spectrin 59
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291466903_702078048750.0RepeatNote=Spectrin 60
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291467021_712878048750.0RepeatNote=Spectrin 61
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-129146704_81578048750.0RepeatNote=Spectrin 5
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291467129_723778048750.0RepeatNote=Spectrin 62
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291467238_735078048750.0RepeatNote=Spectrin 63
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291467351_745478048750.0RepeatNote=Spectrin 64
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291467455_755878048750.0RepeatNote=Spectrin 65
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291467559_767178048750.0RepeatNote=Spectrin 66
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291467672_778378048750.0RepeatNote=Spectrin 67
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-129146816_92378048750.0RepeatNote=Spectrin 6
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-129146924_102478048750.0RepeatNote=Spectrin 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-136314_866601726.0Coiled coilOntology_term=ECO:0000255
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-130146314_866678758798.0Coiled coilOntology_term=ECO:0000255
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-131314_866601444.0Coiled coilOntology_term=ECO:0000255
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-129146314_866678048750.0Coiled coilOntology_term=ECO:0000255
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1368663_872901726.0Compositional biasNote=Ser-rich
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301468663_872978758798.0Compositional biasNote=Ser-rich
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1318663_872901444.0Compositional biasNote=Ser-rich
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291468663_872978048750.0Compositional biasNote=Ser-rich
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-136178_28301726.0DomainCalponin-homology (CH) 2
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-13627_13401726.0DomainCalponin-homology (CH) 1
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1368738_879701726.0DomainKASH
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301468738_879778758798.0DomainKASH
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-131178_28301444.0DomainCalponin-homology (CH) 2
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-13127_13401444.0DomainCalponin-homology (CH) 1
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1318738_879701444.0DomainKASH
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291468738_879778048750.0DomainKASH
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1361_28901726.0RegionNote=Actin-binding
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1311_28901444.0RegionNote=Actin-binding
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1361025_112201726.0RepeatNote=Spectrin 8
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1361123_124601726.0RepeatNote=Spectrin 9
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1361247_133501726.0RepeatNote=Spectrin 10
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1361336_144401726.0RepeatNote=Spectrin 11
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1361445_155001726.0RepeatNote=Spectrin 12
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1361551_165301726.0RepeatNote=Spectrin 13
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1361654_176301726.0RepeatNote=Spectrin 14
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1361764_187901726.0RepeatNote=Spectrin 15
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1361880_197601726.0RepeatNote=Spectrin 16
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1361977_208101726.0RepeatNote=Spectrin 17
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1362082_219501726.0RepeatNote=Spectrin 18
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1362196_230301726.0RepeatNote=Spectrin 19
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1362304_240101726.0RepeatNote=Spectrin 20
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1362402_251301726.0RepeatNote=Spectrin 21
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1362514_261901726.0RepeatNote=Spectrin 22
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1362620_273101726.0RepeatNote=Spectrin 23
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1362732_283801726.0RepeatNote=Spectrin 24
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1362839_296201726.0RepeatNote=Spectrin 25
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1362963_306201726.0RepeatNote=Spectrin 26
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1363063_317101726.0RepeatNote=Spectrin 27
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-136314_39701726.0RepeatNote=Spectrin 1
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1363172_327501726.0RepeatNote=Spectrin 28
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1363276_338701726.0RepeatNote=Spectrin 29
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1363388_349001726.0RepeatNote=Spectrin 30
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1363491_359301726.0RepeatNote=Spectrin 31
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1363594_372001726.0RepeatNote=Spectrin 32
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1363721_381401726.0RepeatNote=Spectrin 33
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1363815_392001726.0RepeatNote=Spectrin 34
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1363921_402801726.0RepeatNote=Spectrin 35
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-136398_50201726.0RepeatNote=Spectrin 2
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1364029_413901726.0RepeatNote=Spectrin 36
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1364140_423501726.0RepeatNote=Spectrin 37
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1364236_433901726.0RepeatNote=Spectrin 38
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1364340_445101726.0RepeatNote=Spectrin 39
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1364452_456001726.0RepeatNote=Spectrin 40
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1364561_466901726.0RepeatNote=Spectrin 41
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1364670_477601726.0RepeatNote=Spectrin 42
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1364777_488201726.0RepeatNote=Spectrin 43
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1364883_499101726.0RepeatNote=Spectrin 44
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1364992_509901726.0RepeatNote=Spectrin 45
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-136503_60901726.0RepeatNote=Spectrin 3
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1365100_520901726.0RepeatNote=Spectrin 46
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1365210_531801726.0RepeatNote=Spectrin 47
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1365319_542401726.0RepeatNote=Spectrin 48
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1365425_552201726.0RepeatNote=Spectrin 49
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1365523_563001726.0RepeatNote=Spectrin 50
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1365631_573601726.0RepeatNote=Spectrin 51
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1365737_584201726.0RepeatNote=Spectrin 52
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1365962_607101726.0RepeatNote=Spectrin 53
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1366072_617801726.0RepeatNote=Spectrin 54
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-136610_70301726.0RepeatNote=Spectrin 4
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1366374_648501726.0RepeatNote=Spectrin 55
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1366486_658101726.0RepeatNote=Spectrin 56
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1366582_669101726.0RepeatNote=Spectrin 57
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1366692_679501726.0RepeatNote=Spectrin 58
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1366796_690201726.0RepeatNote=Spectrin 59
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1366903_702001726.0RepeatNote=Spectrin 60
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1367021_712801726.0RepeatNote=Spectrin 61
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-136704_81501726.0RepeatNote=Spectrin 5
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1367129_723701726.0RepeatNote=Spectrin 62
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1367238_735001726.0RepeatNote=Spectrin 63
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1367351_745401726.0RepeatNote=Spectrin 64
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1367455_755801726.0RepeatNote=Spectrin 65
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1367559_767101726.0RepeatNote=Spectrin 66
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1367672_778301726.0RepeatNote=Spectrin 67
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1367784_788301726.0RepeatNote=Spectrin 68
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1367884_799701726.0RepeatNote=Spectrin 69
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1367998_810601726.0RepeatNote=Spectrin 70
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1368107_821601726.0RepeatNote=Spectrin 71
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-136816_92301726.0RepeatNote=Spectrin 6
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1368329_843801726.0RepeatNote=Spectrin 72
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1368439_854801726.0RepeatNote=Spectrin 73
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1368549_866601726.0RepeatNote=Spectrin 74
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-136924_102401726.0RepeatNote=Spectrin 7
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301467784_788378758798.0RepeatNote=Spectrin 68
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301467884_799778758798.0RepeatNote=Spectrin 69
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301467998_810678758798.0RepeatNote=Spectrin 70
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301468107_821678758798.0RepeatNote=Spectrin 71
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301468329_843878758798.0RepeatNote=Spectrin 72
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301468439_854878758798.0RepeatNote=Spectrin 73
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301468549_866678758798.0RepeatNote=Spectrin 74
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1311025_112201444.0RepeatNote=Spectrin 8
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1311123_124601444.0RepeatNote=Spectrin 9
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1311247_133501444.0RepeatNote=Spectrin 10
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1311336_144401444.0RepeatNote=Spectrin 11
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1311445_155001444.0RepeatNote=Spectrin 12
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1311551_165301444.0RepeatNote=Spectrin 13
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1311654_176301444.0RepeatNote=Spectrin 14
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1311764_187901444.0RepeatNote=Spectrin 15
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1311880_197601444.0RepeatNote=Spectrin 16
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1311977_208101444.0RepeatNote=Spectrin 17
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1312082_219501444.0RepeatNote=Spectrin 18
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1312196_230301444.0RepeatNote=Spectrin 19
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1312304_240101444.0RepeatNote=Spectrin 20
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1312402_251301444.0RepeatNote=Spectrin 21
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1312514_261901444.0RepeatNote=Spectrin 22
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1312620_273101444.0RepeatNote=Spectrin 23
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1312732_283801444.0RepeatNote=Spectrin 24
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1312839_296201444.0RepeatNote=Spectrin 25
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1312963_306201444.0RepeatNote=Spectrin 26
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1313063_317101444.0RepeatNote=Spectrin 27
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-131314_39701444.0RepeatNote=Spectrin 1
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1313172_327501444.0RepeatNote=Spectrin 28
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1313276_338701444.0RepeatNote=Spectrin 29
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1313388_349001444.0RepeatNote=Spectrin 30
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1313491_359301444.0RepeatNote=Spectrin 31
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1313594_372001444.0RepeatNote=Spectrin 32
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1313721_381401444.0RepeatNote=Spectrin 33
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1313815_392001444.0RepeatNote=Spectrin 34
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1313921_402801444.0RepeatNote=Spectrin 35
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-131398_50201444.0RepeatNote=Spectrin 2
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1314029_413901444.0RepeatNote=Spectrin 36
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1314140_423501444.0RepeatNote=Spectrin 37
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1314236_433901444.0RepeatNote=Spectrin 38
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1314340_445101444.0RepeatNote=Spectrin 39
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1314452_456001444.0RepeatNote=Spectrin 40
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1314561_466901444.0RepeatNote=Spectrin 41
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1314670_477601444.0RepeatNote=Spectrin 42
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1314777_488201444.0RepeatNote=Spectrin 43
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1314883_499101444.0RepeatNote=Spectrin 44
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1314992_509901444.0RepeatNote=Spectrin 45
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-131503_60901444.0RepeatNote=Spectrin 3
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1315100_520901444.0RepeatNote=Spectrin 46
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1315210_531801444.0RepeatNote=Spectrin 47
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1315319_542401444.0RepeatNote=Spectrin 48
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1315425_552201444.0RepeatNote=Spectrin 49
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1315523_563001444.0RepeatNote=Spectrin 50
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1315631_573601444.0RepeatNote=Spectrin 51
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1315737_584201444.0RepeatNote=Spectrin 52
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1315962_607101444.0RepeatNote=Spectrin 53
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1316072_617801444.0RepeatNote=Spectrin 54
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-131610_70301444.0RepeatNote=Spectrin 4
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1316374_648501444.0RepeatNote=Spectrin 55
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1316486_658101444.0RepeatNote=Spectrin 56
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1316582_669101444.0RepeatNote=Spectrin 57
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1316692_679501444.0RepeatNote=Spectrin 58
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1316796_690201444.0RepeatNote=Spectrin 59
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1316903_702001444.0RepeatNote=Spectrin 60
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1317021_712801444.0RepeatNote=Spectrin 61
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-131704_81501444.0RepeatNote=Spectrin 5
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1317129_723701444.0RepeatNote=Spectrin 62
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1317238_735001444.0RepeatNote=Spectrin 63
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1317351_745401444.0RepeatNote=Spectrin 64
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1317455_755801444.0RepeatNote=Spectrin 65
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1317559_767101444.0RepeatNote=Spectrin 66
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1317672_778301444.0RepeatNote=Spectrin 67
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1317784_788301444.0RepeatNote=Spectrin 68
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1317884_799701444.0RepeatNote=Spectrin 69
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1317998_810601444.0RepeatNote=Spectrin 70
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1318107_821601444.0RepeatNote=Spectrin 71
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-131816_92301444.0RepeatNote=Spectrin 6
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1318329_843801444.0RepeatNote=Spectrin 72
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1318439_854801444.0RepeatNote=Spectrin 73
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1318549_866601444.0RepeatNote=Spectrin 74
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-131924_102401444.0RepeatNote=Spectrin 7
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291467784_788378048750.0RepeatNote=Spectrin 68
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291467884_799778048750.0RepeatNote=Spectrin 69
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291467998_810678048750.0RepeatNote=Spectrin 70
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291468107_821678048750.0RepeatNote=Spectrin 71
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291468329_843878048750.0RepeatNote=Spectrin 72
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291468439_854878048750.0RepeatNote=Spectrin 73
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291468549_866678048750.0RepeatNote=Spectrin 74
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1361_874601726.0Topological domainCytoplasmic
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1368768_879701726.0Topological domainPerinuclear space
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301461_874678758798.0Topological domainCytoplasmic
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301468768_879778758798.0Topological domainPerinuclear space
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1311_874601444.0Topological domainCytoplasmic
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1318768_879701444.0Topological domainPerinuclear space
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291461_874678048750.0Topological domainCytoplasmic
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291468768_879778048750.0Topological domainPerinuclear space
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367253-1368747_876701726.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneSYNE1chr6:152497529chr6:131924344ENST00000367255-1301468747_876778758798.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneSYNE1chr6:152497529chr6:131924344ENST00000413186-1318747_876701444.0TransmembraneHelical%3B Anchor for type IV membrane protein
HgeneSYNE1chr6:152497529chr6:131924344ENST00000423061-1291468747_876778048750.0TransmembraneHelical%3B Anchor for type IV membrane protein


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Fusion Gene Sequence for SYNE1-MED23


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>88409_88409_1_SYNE1-MED23_SYNE1_chr6_152497529_ENST00000423061_MED23_chr6_131924344_ENST00000354577_length(transcript)=26502nt_BP=23851nt
CGGCCGCCGGCCGCAGCGGGCTGAGATTGTTGTCCTCTGTCACCAGGGCGGCTGGGCTCCCGCAGTCCTGCAGACCGCGCCCGATCCCGG
CGACAGGGCGGGCGGACAGCCGCGCATCCCCGGGGTCCCGCCGAGCCTGGGCGCAGAGAGCCGGGAGGAAGCGTTCGCTCGCTTCGCCTT
GCTGCTGGGAAACTGAACGAGGCCGAGAGAGAAGGTTCTTGAGTTCATGTAAGAGGACAGTCTTAAAACGGAAGAAGAAAAAGAAGCAGT
TCAGTCTTTGGGAGAGCTGCCTCCTTGTTGAGTGCTGCAAAGGCCTGGAATTCATTTATGACAGAATAGATCTAGAAAAGTCCAAGCATG
TTTTCTAGAGTGGTGTAGCCCTGTGCTGCCTCCAGTGAAGAGTCTCTTGGTGTTGGCTTCGTGCTTCCGGAGGGACCATGGCAACCTCCA
GAGGGGCCTCCCGGTGTCCTCGGGATATCGCCAATGTGATGCAGAGGCTGCAAGATGAGCAAGAGATAGTACAAAAACGAACTTTCACAA
AATGGATCAACTCTCATCTGGCCAAGCGGAAACCTCCAATGGTGGTGGACGATCTTTTTGAAGACATGAAAGATGGTGTTAAACTGCTTG
CCCTTCTGGAGGTCCTGTCTGGGCAGAAACTGCCTTGTGAACAAGGACGCCGGATGAAGCGAATCCATGCTGTGGCTAACATTGGCACGG
CACTCAAGTTCCTCGAAGGAAGAAAGTCCATGCACAGAGGATCACCGATTAAATTAGTCAACATTAACTCCACCGATATAGCTGATGGCC
GACCCTCAATAGTTCTTGGATTGATGTGGACCATTATTCTATATTTCCAGATTGAAGAGTTGACCAGCAACCTGCCCCAGCTCCAGTCTT
TGTCCAGCAGCGCATCCTCCGTGGACAGCATAGTTAGCTCTGAGACTCCCAGCCCACCAAGTAAACGGAAGGTGACCACCAAGATCCAAG
GAAATGCTAAGAAGGCTTTATTAAAGTGGGTTCAGTACACAGCTGGCAAGCAGACTGGAATAGAAGTAAAAGATTTTGGGAAGAGTTGGA
GAAGCGGGGTTGCCTTTCATTCAGTTATTCATGCCATTCGACCGGAATTGGTGGACTTGGAGACAGTGAAAGGCAGATCCAACCGAGAAA
ATTTGGAGGATGCTTTCACTATCGCCGAAACAGAACTGGGGATCCCAAGACTGCTAGATCCTGAAGACGTTGATGTGGATAAACCAGATG
AGAAATCTATTATGACCTATGTAGCCCAGTTTCTGAAACATTATCCTGACATCCACAATGCAAGCACTGATGGGCAAGAGGATGATGAAA
TACTTCCAGGTTTCCCATCTTTTGCAAATTCTGTACAAAATTTTAAGAGAGAAGACAGAGTAATTTTTAAGGAAATGAAAGTTTGGATAG
AACAATTTGAGAGAGATTTGACAAGAGCACAGATGGTGGAATCAAATTTACAGGATAAATATCAGTCATTTAAGCACTTCAGAGTTCAAT
ATGAAATGAAGAGGAAACAGATTGAACATTTAATACAACCATTACACAGAGACGGTAAATTGTCACTTGACCAAGCATTGGTAAAACAAT
CTTGGGATAGAGTGACCTCCAGGCTCTTTGACTGGCATATACAGCTTGATAAATCTCTTCCTGCACCTCTGGGCACCATAGGTGCCTGGC
TGTACAGAGCGGAGGTGGCCCTGAGAGAGGAAATAACCGTTCAACAGGTCCACGAGGAAACAGCAAACACGATACAACGGAAACTTGAGC
AACATAAGGATCTGCTTCAAAACACGGATGCCCACAAAAGAGCATTCCATGAAATCTACCGGACCAGGTCTGTTAACGGGATTCCAGTGC
CACCTGATCAATTAGAGGACATGGCCGAGAGGTTTCATTTTGTTTCCTCCACATCAGAGCTACACCTAATGAAAATGGAATTTTTAGAAT
TAAAGTACCGTCTGCTCTCACTGCTGGTTCTTGCAGAGTCAAAGCTGAAGTCTTGGATCATTAAGTACGGGAGGAGAGAGTCAGTGGAGC
AGCTTCTACAAAACTACGTGTCTTTTATAGAAAATAGCAAGTTCTTTGAACAATATGAGGTGACATACCAGATCTTGAAACAGACAGCTG
AGATGTATGTCAAAGCAGATGGTTCAGTGGAAGAAGCTGAGAATGTGATGAAATTCATGAATGAAACCACCGCTCAGTGGAGGAATCTCT
CAGTAGAAGTGAGGAGTGTGAGGAGCATGCTGGAAGAAGTGATCTCTAACTGGGATCGCTATGGCAATACAGTGGCTAGTCTGCAAGCCT
GGCTAGAGGATGCTGAAAAAATGCTCAATCAATCAGAAAATGCCAAAAAGGATTTTTTTCGAAATTTACCTCATTGGATTCAGCAGCATA
CTGCCATGAACGATGCTGGCAATTTTCTAATTGAAACCTGTGATGAGATGGTTTCCCGTGACCTGAAGCAGCAATTACTGTTGCTAAATG
GGCGGTGGAGGGAGTTGTTTATGGAAGTCAAGCAATATGCTCAAGCTGATGAGATGGACAGAATGAAGAAGGAATACACAGACTGTGTTG
TTACCCTGTCTGCTTTTGCAACGGAAGCCCATAAGAAACTTTCTGAACCCTTAGAAGTCTCTTTTATGAATGTCAAGCTATTAATTCAAG
ACTTGGAGGATATTGAGCAGAGGGTGCCTGTGATGGATGCCCAATACAAGATAATTACAAAGACAGCACACCTCATTACCAAAGAAAGCC
CCCAAGAAGAAGGAAAAGAAATGTTTGCGACCATGTCAAAGCTCAAAGAGCAGCTAACCAAGGTCAAAGAATGTTACTCCCCACTCCTTT
ATGAGTCTCAGCAGCTGTTGATTCCGTTGGAGGAATTAGAAAAGCAGATGACGTCCTTTTATGACTCACTTGGGAAAATCAATGAAATTA
TCACAGTTCTTGAGCGTGAGGCACAATCGAGTGCCCTTTTTAAACAAAAACATCAGGAACTGTTAGCTTGTCAAGAAAACTGTAAGAAAA
CCTTGACACTTATTGAGAAAGGCAGTCAAAGTGTTCAAAAGTTTGTGACCTTGAGCAACGTGTTAAAGCATTTTGATCAGACGAGGCTAC
AAAGACAGATTGCAGATATTCATGTTGCTTTTCAGAGTATGGTAAAGAAAACTGGAGATTGGAAGAAGCATGTGGAAACCAACAGTCGCT
TGATGAAGAAGTTTGAGGAGTCTCGAGCAGAGTTGGAGAAGGTACTGCGGATTGCTCAGGAGGGCCTGGAGGAAAAGGGGGATCCAGAGG
AGCTCCTGCGGAGACACACTGAGTTTTTCAGTCAGCTGGATCAGAGGGTGCTCAATGCTTTCCTGAAAGCTTGTGATGAACTCACCGACA
TCCTTCCAGAGCAGGAGCAGCAGGGGCTGCAGGAAGCTGTTCGAAAGCTCCACAAACAATGGAAGGATCTTCAAGGAGAAGCCCCTTATC
ATTTGCTTCATCTGAAGATTGATGTGGAGAAGAATAGGTTCTTAGCCTCTGTAGAAGAATGCAGAACTGAGCTGGATCGAGAGACCAAGC
TGATGCCCCAGGAAGGCAGTGAAAAGATAATTAAAGAGCACAGGGTTTTCTTCAGTGACAAAGGTCCTCATCATCTCTGTGAGAAAAGGT
TACAGCTCATCGAGGAACTCTGTGTGAAACTCCCAGTGCGGGACCCAGTAAGGGACACACCTGGAACCTGTCACGTGACTCTCAAAGAGC
TCAGAGCTGCCATTGACAGCACCTACAGGAAGCTCATGGAAGACCCAGACAAGTGGAAGGACTACACTAGCAGATTCTCTGAGTTCTCAT
CTTGGATATCTACAAATGAGACACAATTAAAGGGGATCAAGGGTGAGGCCATCGATACTGCCAACCACGGAGAGGTTAAACGTGCCGTTG
AAGAGATCAGAAATGGTGTTACCAAAAGGGGTGAGACCCTCAGCTGGCTGAAATCCAGGCTGAAAGTTTTGACAGAAGTTTCTTCTGAGA
ATGAAGCCCAAAAGCAGGGAGATGAGCTGGCAAAATTATCCAGCTCTTTCAAGGCTCTTGTGACGCTGCTGTCAGAGGTTGAAAAGATGC
TAAGCAATTTTGGGGACTGTGTCCAGTACAAAGAAATAGTCAAAAATTCTCTCGAAGAATTAATTTCTGGCTCTAAAGAAGTCCAGGAAC
AAGCTGAGAAGATCTTGGATACTGAAAATCTGTTTGAAGCACAGCAGTTACTTCTTCATCACCAGCAAAAGACAAAGCGGATCTCAGCAA
AGAAGAGAGATGTGCAGCAGCAGATCGCGCAGGCGCAGCAGGGAGAAGGGGGGCTGCCTGACCGAGGCCACGAGGAGCTGCGGAAGCTGG
AGAGCACACTGGATGGCCTGGAGCGCAGCCGGGAGAGGCAGGAACGCCGCATCCAGGTCACATTAAGAAAATGGGAGCGATTTGAAACAA
ACAAAGAAACAGTAGTAAGATACCTTTTTCAAACAGGTTCCAGTCATGAACGCTTCTTGAGTTTTAGCAGTTTGGAAAGTTTATCTTCAG
AACTGGAACAAACAAAGGAGTTTTCTAAACGGACAGAAAGTATTGCAGTCCAGGCTGAGAACCTTGTAAAGGAAGCTTCAGAGATACCGC
TTGGGCCCCAAAATAAGCAGCTGCTTCAACAGCAGGCCAAGTCAATCAAAGAACAAGTCAAAAAATTAGAAGACACGCTTGAAGAAGATA
TTAAAACCATGGAAATGGTGAAAACCAAGTGGGATCATTTTGGCAGTAATTTTGAGACTCTGTCCGTCTGGATAACTGAGAAAGAAAAAG
AACTCAATGCCTTGGAAACTTCGTCATCTGCCATGGACATGCAAATCAGCCAAATTAAGGTCACAATTCAGGAAATAGAAAGTAAGCTCA
GCAGCATTGTAGGATTAGAAGAAGAAGCCCAGTCTTTTGCTCAGTTTGTTACCACTGGAGAATCTGCTCGAATTAAAGCCAAGTTGACAC
AAATAAGAAGATACGGGGAAGAGCTTCGAGAGCATGCACAGTGTCTGGAAGGAACAATCCTGGGACATTTATCTCAGCAGCAAAAGTTTG
AAGAGAACCTTAGAAAGATCCAGCAATCTGTGTCTGAATTTGAAGATAAACTTGCTGTTCCAATTAAAATATGTTCTTCAGCTACAGAAA
CATACAAAGTTCTTCAAGAACATATGGATCTCTGCCAGGCCCTGGAGTCACTGAGCAGCGCGATCACTGCCTTCTCAGCCAGTGCCAGGA
AGGTTGTGAACAGAGATTCCTGTGTTCAGGAGGCTGCGGCTCTACAGCAGCAATACGAGGACATCCTAAGGAGGGCGAAGGAGAGACAGA
CGGCGCTGGAGAATCTGCTGGCCCACTGGCAGAGGCTAGAGAAAGAACTATCATCCTTTTTGACCTGGTTAGAGCGGGGTGAAGCTAAAG
CCAGTTCCCCAGAAATGGACATTTCTGCAGACAGAGTCAAAGTGGAAGGTGAACTTCAGTTAATACAGGCACTGCAAAATGAAGTTGTAT
CCCAGGCCTCATTCTATAGCAAACTTTTGCAATTGAAGGAATCATTGTTCTCAGTAGCCTCCAAAGATGATGTGAAAATGATGAAACTAC
ATTTGGAGCAGTTGGATGAGAGATGGAGAGATTTACCACAGATCATTAACAAAAGGATTAATTTTCTTCAGTCTGTGGTTGCTGAACACC
AGCAATTTGATGAGCTGCTGCTTTCCTTTTCTGTCTGGATTAAACTGTTTCTCAGTGAATTACAAACTACCTCTGAGATTAGCATAATGG
ACCATCAAGTAGCCCTTACTCGGCATAAGGACCACGCAGCAGAAGTAGAGAGCAAAAAGGGCGAATTGCAGAGTCTGCAGGGTCACTTAG
CAAAGTTGGGTTCTCTGGGCCGTGCTGAGGACCTCCACCTCCTGCAGGGAAAGGCTGAGGACTGCTTCCAGCTGTTTGAGGAGGCCAGCC
AGGTTGTGGAGAGGCGGCAGCTTGCCCTGTCCCATTTGGCAGAATTCCTCCAGAGCCATGCCTCTCTGTCCGGCATTCTCCGCCAGCTGA
GGCAAACAGTGGAAGCAACCAACAGTATGAATAAGAACGAGTCTGATTTGATAGAAAAGGACCTCAATGATGCTCTTCAAAATGCTAAAG
CATTAGAATCTGCTGCCGTCAGTCTGGATGGCATTCTTTCCAAAGCCCAATACCATCTGAAAATCGGGAGCTCTGAGCAAAGGACTTCCT
GCAGAGCCACGGCTGATCAGCTCTGTGGAGAGGTAGAGAGGATCCAGAACCTTCTGGGAACCAAGCAGAGTGAGGCAGATGCTCTGGCAG
TGTTGAAAAAAGCATTCCAAGACCAGAAAGAGGAGCTTCTGAAAAGCATTGAGGACATTGAAGAAAGGACTGACAAAGAGCGATTGAAAG
AACCTACCCGCCAAGCTCTTCAGCAGAGGTTAAGAGTGTTTAATCAGCTAGAAGATGAATTGAATTCTCACGAGCATGAACTATGTTGGT
TGAAAGACAAAGCCAAGCAAATTGCCCAGAAAGATGTAGCTTTTGCACCTGAAGTTGACAGGGAGATAAACCGCTTAGAGGTCACCTGGG
ATGATACCAAAAGACTAATTCATGAAAATCAGGGTCAGTGCTGTGGACTTATTGACTTAATGAGAGAATATCAGAACCTGAAATCAGCTG
TATCTAAAGTCTTAGAAAATGCCAGCAGTGTGATTGTAACCAGAACTACCATAAAAGATCAGGAGGATCTTAAATGGGCTTTTTCCAAGC
ATGAAACTGCCAAGAACAAAATGAATTACAAACAGAAAGACTTGGATAACTTTACCAGCAAAGGAAAACACTTGTTATCTGAGCTGAAGA
AAATTCACAGTAGTGATTTCAGCTTGGTGAAAACAGACATGGAGAGCACCGTGGACAAATGGCTGGATGTATCAGAGAAACTTGAAGAAA
ACATGGATAGGCTGAGAGTAAGCCTGTCCATTTGGGATGATGTACTGTCAACTAGAGATGAGATTGAGGGATGGTCAAACAACTGCGTTC
CACAGATGGCAGAAAACATCAGCAACCTGGATAACCACCTCAGAGCTGAAGAACTGCTTAAAGAATTTGAGTCTGAAGTTAAAAACAAAG
CATTGAGATTGGAAGAACTGCATTCCAAAGTTAATGATCTGAAAGAATTAACTAAAAATCTAGAAACACCGCCAGACCTTCAGTTTATAG
AAGCAGACTTAATGCAGAAACTGGAGCATGCCAAAGAAATAACTGAAGTAGCAAAAGGAACCCTGAAGGATTTCACGGCTCAAAGTACAC
AAGTGGAGAAGTTTATTAATGACATAACAACATGGTTCACAAAAGTGGAAGAATCGTTGATGAACTGTGCCCAAAATGAGACTTGTGAAG
CATTGAAAAAAGTCAAGGATATACAAAAAGAACTTCAAAGTCAACAAAGCAACATCAGCTCTACCCAAGAAAATCTCAATAGCTTGTGCC
GCAAGTACCACTCAGCTGAGTTGGAGAGCCTGGGCCGTGCAATGACTGGTCTGATAAAGAAACATGAAGCCGTGAGCCAGTTGTGCTCCA
AAACCCAGGCCAGCCTGCAGGAATCTCTGGAAAAACACTTCAGTGAGTCTATGCAGGAATTCCAAGAATGGTTTTTGGGAGCAAAGGCAG
CAGCAAAAGAATCATCAGATCGCACCGGTGACAGCAAAGTTCTAGAAGCAAAGCTCCATGATCTTCAGAACATTTTGGACTCAGTCAGTG
ATGGGCAGAGCAAACTTGATGCAGTGACTCAAGAAGGACAAACTTTGTATGCACATTTGTCTAAACAAATTGTCAGTAGCATTCAAGAAC
AAATCACAAAGGCCAATGAAGAGTTTCAAGCATTTCTGAAACAATGCCTTAAAGATAAGCAGGCTCTTCAAGACTGTGCTTCAGAACTTG
GAAGCTTTGAAGATCAGCACAGAAAACTGAACTTATGGATCCATGAAATGGAAGAAAGGTTCAATACGGAAAACTTGGGAGAGAGTAAAC
AGCACATTCCTGAGAAGAAAAATGAAGTTCATAAAGTTGAAATGTTTTTGGGAGAACTGCTGGCTGCAAGAGAGTCTCTTGATAAGCTTT
CCCAGAGAGGGCAGCTTCTGAGTGAAGAAGGCCACGGTGCTGGGCAGGAGGGCCGCCTGTGTTCCCAGCTCCTCACAAGCCACCAGAACC
TACTTAGAATGACCAAAGAGAAACTCCGGAGCTGCCAGGTGGCCCTTCAGGAGCACGAAGCCCTGGAGGAAGCACTGCAAAGCATGTGGT
TCTGGGTGAAGGCCATTCAGGACAGACTGGCCTGTGCAGAGAGCACTCTTGGGAGCAAAGACACCCTGGAGAAACGGCTGTCACAAATAC
AGGATATTCTCCTGATGAAAGGTGAAGGGGAAGTTAAGTTGAATATGGCCATTGGCAAGGGGGAACAGGCCTTGAGAAGTAGCAACAAAG
AAGGTCAGAGGGTGATTCAGACTCAGTTAGAGACCCTTAAAGAAGTGTGGGCTGACATCATGAGCTCCTCCGTCCACGCTCAAAGCACTT
TAGAGTCTGTGATTAGCCAATGGAATGACTATGTAGAGAGGAAAAACCAGTTGGAGCAGTGGATGGAATCAGTGGATCAAAAAATAGAAC
ATCCCTTACAACCACAGCCAGGTCTGAAAGAGAAGTTCGTCCTGCTTGACCACCTCCAGTCCATCCTGTCTGAGGCAGAAGATCACACGA
GAGCCCTTCACCGTCTAATTGCGAAGTCCAGGGAGCTCTACGAAAAGACAGAGGATGAGTCTTTCAAGGACACAGCTCAAGAGGAGCTGA
AAACACAGTTTAATGATATAATGACTGTTGCCAAGGAAAAAATGAGGAAAGTGGAAGAGATTGTGAAAGATCATCTAATGTATTTAGATG
CGGTCCACGAGTTCACAGATTGGCTCCATTCAGCAAAGGAAGAACTTCACCGGTGGTCAGATATGTCTGGAGATTCATCAGCCACCCAGA
AAAAGTTATCAAAAATTAAGGAGCTGATAGATTCCAGAGAGATTGGTGCAAGCCGTCTCAGCAGAGTGGAGTCGCTGGCTCCCGAAGTGA
AACAGAACACAACTGCCAGTGGGTGTGAGCTCATGCACACGGAGATGCAGGCCCTGCGTGCCGACTGGAAGCAGTGGGAAGACAGTGTAT
TCCAAACGCAGAGCTGTTTGGAGAACCTGGTCAGCCAGATGGCCCTTTCGGAGCAGGAATTCTCAGGCCAAGTGGCTCAACTGGAGCAGG
CCCTGGAACAGTTCAGTGCCCTTCTGAAAACCTGGGCTCAGCAGTTAACCCTCCTGGAAGGCAAGAACACGGATGAGGAGATAGTGGAAT
GCTGGCACAAAGGACAAGAGATACTGGATGCTTTGCAAAAAGCAGAGCCTAGAACAGAGGATCTCAAGTCTCAGCTGAATGAACTTTGTC
GATTTTCCAGAGACCTGAGTACCTACAGTGGAAAAGTTTCTGGCTTGATTAAAGAGTATAATTGTCTTTGTTTGCAAGCATCCAAGGGCT
GCCAGAATAAAGAACAGATTTTACAGCAAAGATTTCGAAAGGCCTTCAGGGATTTCCAGCAGTGGTTGGTTAATGCAAAAATCACTACCG
CCAAGTGTTTTGATATACCTCAAAATATAAGTGAAGTTTCAACTAGTCTTCAGAAAATACAGGAGTTTTTGTCAGAAAGTGAAAATGGAC
AGCACAAGCTAAACATGATGCTGTCTAAAGGGGAACTTCTGAGTACCCTGCTGACCAAAGAGAAAGCGAAAGGGATCCAGGCCAAAGTTA
CAGCTGCAAAAGAAGATTGGAAAAATTTTCATTCAAATCTCCACCAAAAAGAATCTGCTCTAGAGAATCTAAAGATCCAAATGAAGGACT
TTGAAGTAAGTGCTGAGCCTATCCAGGACTGGCTGAGTAAAACTGAGAAGATGGTCCATGAAAGCAGCAATCGCCTCTATGATCTGCCAG
CAAAGAGGAGGGAGCAGCAGAAGCTCCAGTCTGTCCTTGAGGAAATACACTGCTACGAGCCTCAGCTCAACAGGCTGAAAGAGAAAGCTC
AGCAGCTGTGGGAAGGACAAGCTGCCAGCAAGAGCTTTAGGCACAGAGTGTCGCAGCTGTCTTCTCAGTATCTAGCGCTAAGCAATTTAA
CAAAGGAGAAAGTGTCAAGACTGGATAGAATCGTTGCAGAACACAATCAGTTCTCTCTTGGGATTAAAGAATTACAAGACTGGATGACGG
ATGCGATTCACATGCTGGATTCATACTGCCACCCGACATCCGACAAAAGTGTGCTGGACAGCAGGACGCTCAAGCTCGAGGCTCTATTAT
CAGTCAAACAGGAAAAAGAGATTCAGATGAAAATGATAGTGACCAGGGGAGAATCTGTCCTTCAGAATACTTCTCCAGAAGGCATTCCCA
CTATTCAGCAGCAGCTGCAGAGTGTGAAGGATATGTGGGCATCCCTTTTGTCTGCAGGGATTCGTTGTAAAAGCCAACTCGAAGGAGCTC
TCTCCAAGTGGACAAGTTATCAGGATGGCGTTCGACAGTTCTCCGGTTGGATGGATAGTATGGAAGCCAACCTGAATGAATCAGAAAGGC
AGCATGCGGAGCTGCGGGATAAAACAACGATGCTCGGAAAAGCCAAGTTATTAAATGAAGAAGTGCTGAGTTACAGCAGCTTGCTGGAGA
CCATCGAAGTCAAAGGGGCTGGCATGACAGAACACTATGTCACCCAGCTAGAACTCCAGGATCTACAGGAACGATACAGAGCCATCCAAG
AGAGGGCCAAGGAAGCCGTAACCAAGTCTGAAAAACTTGTCCGCCTGCACCAAGAGTATCAGAGAGACCTAAAGGCATTTGAAGTTTGGT
TGGGGCAAGAACAAGAAAAGCTCGACCAGTATTCAGTTCTTGAAGGTGATGCCCACACTCATGAGACAACATTGCGTGATCTTCAGGAGC
TACAGGTACACTGTGCAGAGGGGCAGGCCCTGTTGAACTCAGTGCTGCACACCAGAGAGGATGTGATCCCATCAGGTATCCCACAGGCAG
AGGACCGGGCTTTAGAGTCTCTCCGGCAAGACTGGCAGGCTTACCAGCACAGGCTGTCCGAGACTCGAACTCAGTTCAATAACGTGGTGA
ACAAATTGAGGCTAATGGAGCAAAAGTTTCAGCAAGTAGATGAATGGCTCAAAACAGCAGAGGAGAAAAAGTGGCACGAAGAAGTGACTG
CATACAGAGATGAAGTTGAGGAAGTGGGAGCTAGAGCTCAGGAGATACTGGACGAGAGCCACGTGAACAGCAGAATGGGTTGCCAGGCCA
CCCAGCTGACTTCCAGATACCAGGCCCTGCTTCTCCAAGTGCTGGAACAAATAAAATTCCTGGAGGAGGAGATTCAGAGTTTGGAGGAAT
CAGAATCATCCCTCAGTTCCTATTCTGATTGGTATGGCTCTACTCATAAAAACTTCAAGAATGTGGCTACCAAGATTGACAAAGTAGATA
CAGTAATGATGGGGAAGAAATTGAAGACGTTGGAGGTTTTGCTCAAAGACATGGAGAAAGGTCACAGTTTGCTGAAATCAGCCCGGGAGA
AAGGAGAGAGGGCTGTTAAATACTTGGAGGAAGGCGAGGCAGAGAGGTTAAGAAAGGAGATTCATGATCACATGGAGCAGTTGAAGGAAC
TGACCAGCACTGTCCGGAAAGAACACATGACGCTGGAAAAAGGTCTTCATTTAGCAAAGGAATTCTCAGATAAATGCAAAGCACTGACAC
AGTGGATAGCAGAATACCAGGAAATTCTACATGTTCCTGAAGAACCCAAAATGGAATTATATGAGAAAAAAGCTCAGTTATCTAAATACA
AGTCACTTCAACAAACGGTGCTGTCCCATGAACCATCAGTAAAGTCAGTGAGAGAGAAGGGTGAAGCTCTTTTGGAACTGGTGCAGGACG
TCACTTTAAAGGACAAAATAGATCAACTTCAAAGTGATTACCAGGACCTGTGCAGCATAGGAAAGGCAATGATGGAAGAAATTGCTGGTT
TTGAAGACCGTTTGAACAATCTTCAAATGAAAGGTGATACTTTGATTGGCCAATGTGCAGACCACCTGCAAGCGAAACTTAAACAAAACG
TGCATGCTCATCTGCAGGGCACAAAGGACAGCTACTCAGCGATCTGCAGCACAGCTCAGAGGATGTACCAGAGTTTGGAACACGAACTTC
AGAAGCACGTCAGCCGACAAGACACCCTGCAGCAGTGCCAGGCCTGGCTTTCTGCAGTCCAGCCGGATTTAGAGCCAAGTCCTCAACCAC
CTCTTAGTAGGGCAGAAGCCATTAAGCAGGTCAAACACTTCAGAGCTTTGCAAGAGCAGGCAAGGACCTACCTAGATCTCCTTTGCTCCA
TGTGTGACCTGTCAAATGCTTCGGTGAAAACCACAGCAAAAGACATTCAACAAACAGAGCAAACGATTGAACAAAAGCTTGTCCAGGCCC
AGAACTTAACTCAGGGCTGGGAAGAGATCAAGCACCTGAAGTCTGAGCTCTGGATTTACCTGCAAGATGCTGATCAGCAACTGCAGAACA
TGAAGAGGAGGCACTCTGAGCTGGAGCTGAACATTGCACAGAACATGGTTTCACAAGTTAAGGATTTTGTTAAGAAACTACAGAGCAAAC
AGGCATCCGTGAACACCATAATAGAAAAGGTGAATAAGTTAACAAAGAAGGAGGAATCGCCTGAACACAAGGAAATAAATCATTTAAATG
ATCAGTGGCTCGATTTGTGCCGTCAGTCTAACAACCTGTGCTTGCAAAGGGAAGAGGATCTTCAGAGAACAAGAGATTACCATGACTGTA
TGAATGTTGTTGAAGTGTTCCTAGAAAAATTTACTACAGAATGGGATAACTTGGCCAGATCTGATGCAGAGAGTACAGCTGTCCACCTGG
AAGCTTTGAAAAAGTTAGCATTGGCATTGCAGGAGAGAAAGTATGCTATTGAAGATCTGAAAGATCAAAAGCAGAAAATGATAGAGCATC
TGAATTTAGATGACAAGGAGTTAGTCAAAGAACAGACGAGTCATTTAGAGCAACGTTGGTTTCAGCTTGAGGACCTCATTAAAAGGAAAA
TCCAAGTGTCAGTCACCAACTTGGAGGAGTTAAATGTGGTGCAGTCCAGATTTCAGGAGCTAATGGAGTGGGCAGAAGAGCAACAACCCA
ACATCGCCGAGGCCCTTAAGCAGAGCCCTCCTCCAGATATGGCTCAGAACCTTCTCATGGATCACCTGGCCATCTGCAGTGAACTGGAGG
CCAAGCAGATGCTCCTGAAATCGCTTATAAAGGACGCAGACAGGGTCATGGCAGATCTTGGTCTCAATGAGCGACAGGTCATCCAGAAGG
CTCTCTCTGATGCACAAAGCCACGTGAATTGTCTCAGTGACTTAGTGGGCCAGCGAAGAAAGTACTTAAACAAAGCCTTGTCCGAGAAAA
CCCAGTTTCTCATGGCAGTGTTCCAGGCCACCAGCCAAATTCAGCAACATGAGCGAAAGATAATGTTCCGTGAACACATCTGTCTGTTAC
CAGATGATGTGAGCAAACAAGTCAAAACATGTAAGAGTGCACAAGCCAGCCTCAAGACTTACCAAAATGAAGTCACTGGACTTTGGGCCC
AGGGTCGCGAACTAATGAAGGAAGTCACAGAGCAGGAAAAGAGTGAAGTGCTGGGGAAGCTTCAGGAATTGCAGAGTGTCTATGACAGTG
TTTTACAAAAGTGCAGTCACCGGTTACAAGAACTAGAGAAGAATTTGGTTTCTAGGAAGCATTTTAAGGAAGATTTTGATAAAGCTTGCC
ACTGGCTAAAACAAGCAGATATTGTTACATTTCCTGAAATCAACCTAATGAATGAGAGTTCTGAGCTTCATACACAACTGGCTAAATACC
AAAACATTCTTGAACAATCTCCAGAATATGAAAATCTTCTACTTACGCTGCAGAGAACTGGGCAGACCATATTACCATCGCTGAATGAAG
TCGATCATTCCTACCTCAGTGAAAAGCTAAATGCTTTGCCTCGACAATTTAATGTAATTGTTGCCTTGGCTAAAGACAAGTTCTATAAAG
TCCAGGAAGCAATTCTTGCTCGGAAGGAATATGCTTCCTTGATTGAGTTGACAACCCAGTCTCTGAGTGAACTTGAAGCCCAATTCTTGA
GGATGAGCAAAGTTCCCACCGACCTGGCCGTTGAGGAGGCTCTTTCTCTGCAAGATGGTTGCAGAGCCATTCTGGACGAGGTGGCGGGCC
TTGGGGAGGCGGTGGATGAACTGAACCAGAAAAAAGAAGGTTTTCGCAGCACAGGTCAGCCTTGGCAGCCAGACAAGATGCTGCACCTTG
TCACCTTATATCACAGGCTGAAGCGACAAACAGAACAGAGGGTTAGCTTATTAGAAGACACCACCAGTGCTTACCAAGAACACGAGAAGA
TGTGCCAACAGCTGGAGAGACAACTGAAGTCTGTAAAAGAGGAGCAGTCCAAAGTGAATGAGGAAACGCTGCCTGCAGAGGAGAAGCTCA
AAATGTATCACTCCCTGGCAGGAAGTCTCCAGGACTCAGGGATTGTACTGAAACGAGTAACCATACATCTTGAAGATCTTGCCCCACACC
TTGACCCCTTGGCTTATGAGAAAGCCAGGCATCAGATCCAGTCCTGGCAAGGGGAGTTAAAACTGTTGACTTCTGCCATTGGTGAGACGG
TGACAGAATGTGAGAGCCGAATGGTGCAGAGTATAGACTTCCAGACTGAGATGAGTCGCTCCCTGGACTGGCTGAGGAGAGTGAAGGCAG
AGCTCAGTGGGCCGGTGTACCTAGACCTCAACCTGCAGGACATCCAAGAGGAAATCAGAAAAATCCAAATTCATCAGGAAGAGGTCCAGT
CCAGCTTGAGAATCATGAATGCGCTGAGTCACAAGGAAAAGGAGAAGTTCACAAAGGCCAAGGAGCTGATTTCTGCGGATTTAGAACACA
GCCTCGCTGAGCTCTCAGAGCTGGATGGAGACATCCAGGAAGCCTTACGCACCAGACAGGCTACCTTGACTGAAATATATAGCCAGTGTC
AAAGGTATTATCAGGTATTTCAAGCAGCCAATGACTGGCTTGAGGATGCCCAAGAATTGTTACAGCTGGCAGGCAATGGCCTAGACGTGG
AGAGCGCAGAGGAAAATCTCAAAAGCCACATGGAATTTTTCAGTACAGAGGATCAGTTCCATAGTAACCTGGAGGAGCTCCACAGCCTGG
TAGCCACCCTGGACCCACTCATCAAGCCAACCGGCAAAGAAGACCTAGAACAGAAAGTGGCTTCTCTGGAACTCAGGAGCCAGAGGATGA
GCCGGGACTCTGGTGCCCAAGTGGATCTCTTGCAGAGATGCACAGCTCAATGGCACGATTACCAGAAAGCAAGGGAAGAGGTTATTGAAT
TGATGAATGATACAGAAAAGAAATTGTCTGAGTTTTCTTTGTTGAAGACTTCGTCTAGTCATGAAGCGGAAGAAAAATTGTCAGAACACA
AGGCTTTAGTGTCAGTGGTTAACTCTTTCCATGAGAAAATTGTGGCCCTTGAGGAAAAAGCTTCACAACTGGAGAAAACCGGAAATGATG
CCAGCAAAGCCACCCTGAGCAGGTCAATGACCACCGTCTGGCAGCGCTGGACACGCCTTCGAGCTGTGGCCCAGGACCAGGAGAAGATCC
TGGAAGATGCAGTGGATGAGTGGACGGGCTTTAACAACAAGGTTAAAAAGGCCACTGAAATGATTGATCAGCTGCAAGATAAGTTACCTG
GAAGTTCAGCAGAGAAAGCATCGAAAGCAGAGCTCTTAACTCTTCTTGAATACCACGACACGTTCGTTCTGGAGCTGGAGCAGCAGCAGT
CGGCCTTGGGCATGCTGCGGCAGCAAACCCTGAGCATGCTCCAGGATGGAGCCGCCCCAACCCCTGGGGAAGAGCCTCCGCTCATGCAGG
AAATCACCGCCATGCAAGATCGGTGCCTGAACATGCAGGAGAAAGTGAAGACTAATGGAAAGTTGGTGAAGCAAGAGCTGAAGGACCGAG
AAATGGTGGAGACTCAGATCAATTCTGTGAAATGTTGGGTTCAGGAAACGAAAGAATATTTAGGGAATCCAACAATAGAAATAGATGCTC
AACTTGAAGAACTTCAGATTCTCCTAACAGAAGCCACAAATCACCGACAGAACATTGAAAAAATGGCAGAAGAACAGAAGGAGAAGTACT
TAGGTCTTTATACCATATTACCTTCTGAACTCTCCCTTCAGTTGGCTGAAGTGGCGTTAGATCTAAAGATCCGAGATCAGATCCAAGACA
AAATAAAAGAAGTTGAGCAGAGCAAGGCCACGAGCCAGGAACTCAGCCGGCAAATTCAGAAGTTAGCTAAAGACCTCACAACTATTCTAA
CTAAGCTGAAAGCGAAGACAGATAATGTAGTTCAAGCTAAAACTGACCAAAAGGTGCTGGGAGAGGAATTAGATGGCTGTAATTCAAAGT
TAATGGAATTAGATGCAGCAGTACAGAAATTCTTGGAACAGAATGGCCAACTGGGTAAGCCACTGGCCAAGAAGATAGGAAAACTGACTG
AACTTCACCAGCAGACCATTAGACAAGCTGAGAATCGGCTCTCCAAGCTCAATCAGGCAGCATCACATTTAGAAGAATACAATGAAATGC
TTGAATTAATTTTGAAGTGGATTGAAAAAGCTAAAGTCTTGGCTCATGGAACTATTGCATGGAATTCTGCAAGCCAGCTTCGGGAACAAT
ATATTTTGCATCAGACCCTGCTAGAAGAATCCAAAGAAATTGACAGTGAGCTGGAAGCAATGACTGAGAAATTACAGTACCTCACTAGCG
TGTACTGTACAGAAAAAATGTCTCAGCAAGTGGCAGAACTGGGACGGGAGACTGAGGAGTTGCGACAGATGATCAAAATTCGTTTGCAGA
ACCTCCAAGATGCAGCTAAGGATATGAAAAAATTTGAAGCAGAGTTGAAAAAGTTACAAGCTGCCTTGGAGCAAGCCCAGGCAACACTGA
CTTCTCCAGAAGTTGGACGTCTCAGTCTCAAGGAGCAGCTCTCTCATCGGCAGCATTTGTTGTCTGAGATGGAGTCACTGAAGCCGAAGG
TGCAAGCAGTGCAGCTCTGCCAGAGTGCCCTCCGGATCCCCGAGGATGTGGTTGCCAGCTTACCTCTCTGTCATGCTGCTCTGCGGCTGC
AGGAAGAGGCCAGCCGGCTGCAGCACACCGCCATCCAGCAGTGTAACATCATGCAGGCAGCTGTGGTACAATATGAACAATATGAGCAAG
AAATGAAACATCTCCAGCAACTGATAGAAGGAGCTCACAGAGAGATTGAGGATAAACCTGTTGCCACCAGTAACATACAGGAGCTGCAGG
CTCAGATTTCTCGGCATGAGGAGCTGGCGCAGAAAATTAAGGGCTACCAGGAGCAGATCGCTTCTTTGAATTCCAAGTGCAAGATGCTGA
CGATGAAAGCCAAGCACGCCACCATGCTGCTGACGGTGACCGAGGTCGAGGGGCTGGCGGAAGGGACAGAGGACCTGGATGGGGAGCTCC
TCCCCACGCCTTCGGCCCACCCCTCTGTGGTCATGATGACTGCAGGTCGCTGTCACACTTTGCTGTCACCGGTCACTGAGGAGTCTGGGG
AGGAGGGAACCAACAGTGAGATTTCCTCTCCACCTGCCTGTCGCTCCCCTTCACCTGTGGCTAATACAGATGCTTCTGTTAACCAGGACA
TTGCATATTACCAAGCCTTGTCTGCTGAGAGGTTGCAGACAGATGCTGCAAAAATTCACCCCAGCACATCCGCATCCCAGGAGTTCTATG
AACCGGGATTGGAGCCATCCGCTACTGCCAAACTGGGTGATTTGCAGCGTTCTTGGGAAACCTTAAAGAATGTGATCAGTGAGAAGCAGC
GCACACTCTATGAAGCTTTGGAACGCCAGCAGAAGTACCAGGACTCCCTCCAGTCCATCTCTACGAAGATGGAGGCCATTGAGCTGAAAC
TCAGTGAGAGCCCAGAGCCTGGCAGGAGTCCAGAAAGCCAGATGGCTGAACATCAGGCATTGATGGATGAGATTCTCATGCTCCAGGATG
AAATCAATGAGCTCCAGTCCTCTCTCGCAGAGGAGCTGGTATCCGAGTCTTGTGAGGCCGACCCTGCGGAGCAGCTGGCCTTGCAGTCCA
CGCTCACTGTCTTAGCCGAGCGAATGTCCACCATCAGGATGAAAGCCTCGGGGAAACGGCAGCTTTTGGAGGAGAAGTTGAATGATCAGC
TGGAGGAACAAAGGCAGGAACAGGCCCTGCAGAGGTATCGCTGTGAAGCCGATGAGCTGGACAGCTGGCTCTTGAGTACCAAGGCCACTC
TGGACACTGCGCTGAGTCCACCCAAGGAGCCCATGGACATGGAGGCCCAGCTTATGGACTGCCAGAATATGCTGGTGGAAATAGAGCAGA
AGGTGGTGGCTTTATCAGAACTGTCAGTCCACAATGAGAACCTGCTGCTGGAGGGCAAAGCTCACACCAAGGACGAGGCCGAGCAGCTGG
CTGGAAAGCTGAGAAGGCTCAAGGGGAGCCTGCTGGAGCTGCAGAGAGCCCTGCATGATAAGCAGCTCAACATGCAGGGAACAGCACAGG
AGAAGGAGGAGAGCGATGTTGACCTAACAGCCACGCAGAGCCCCGGCGTCCAGGAATGGCTGGCCCAAGCTCGCACCACATGGACCCAGC
AGCGGCAGAGCAGTCTCCAGCAACAAAAAGAGTTAGAACAGGAATTAGCCGAGCAGAAGAGTCTCCTTCGCTCAGTAGCCAGTCGTGGAG
AGGAGATTCTAATTCAACATTCGGCGGCAGAGACCTCTGGTGATGCTGGCGAAAAACCTGATGTGTTATCCCAGGAGTTGGGGATGGAAG
GGGAGAAATCATCCGCTGAAGACCAGATGAGAATGAAATGGGAAAGCCTACATCAAGAATTTAGTACCAAGCAGAAACTACTACAGAATG
TTCTGGAACAGGAACAAGAGCAAGTGCTTTATAGCAGGCCAAATCGACTCTTGTCTGGTGTGCCACTGTACAAAGGGGACGTGCCAACCC
AAGATAAATCTGCAGTTACATCTTTGCTGGATGGACTGAACCAAGCCTTCGAGGAGGTTTCATCCCAGAGTGGAGGGGCAAAGAGGCAGA
GTATACACTTGGAGCAGAAGTTGTATGATGGAGTCTCAGCCACCTCTACTTGGTTGGATGACGTTGAAGAACGTTTATTTGTTGCCACAG
CACTTTTACCAGAAGAAACAGAGACTTGTCTCTTCAACCAAGAGATTCTTGCCAAAGACATTAAGGAAATGTCTGAAGAAATGGATAAGA
ACAAAAACTTGTTTTCCCAAGCTTTTCCAGAGAATGGTGATAATCGAGATGTTATTGAAGATACTTTGGGTTGTCTTTTGGGCAGGTTAT
CCTTGCTAGACTCAGTAGTGAATCAACGATGTCATCAGATGAAAGAAAGACTTCAGCAAATACTAAATTTCCAGAATGATCTGAAAGTGC
TGTTTACATCACTGGCTGACAACAAATACATCATTCTGCAAAAACTGGCAAATGTGTTTGAACAGCCCGTAGCAGAACAAATAGAGGCAA
TACAACAGGCTGAAGATGGACTCAAAGAATTTGATGCAGGAATCATTGAATTAAAGAGGCGTGGTGACAAGCTACAGGTCGAGCAGCCGT
CCATGCAAGAACTCTCCAAGCTCCAGGACATGTATGATGAGCTGATGATGATCATTGGCTCCCGGAGGAGTGGTCTGAATCAGAACCTTA
CACTCAAGAGTCAGTATGAGAGGGCCCTACAAGATCTGGCTGACCTGCTAGAAACTGGTCAGGAGAAGATGGCAGGAGACCAGAAAATCA
TCGTGTCTTCCAAAGAGGAAATCCAGCAACTACTTGACAAACATAAGGAATACTTTCAGGGCCTGGAATCTCATATGATCTTGACTGAAA
CACTCTTCAGAAAGATAATCAGCTTTGCAGTCCAAAAGGAAACCCAGTTCCATACAGAGCTGATGGCTCAGGCTTCTGCTGTACTGAAAC
GGGCTCACAAGAGGGGTGTGGAGCTGGAGTACATTCTAGAGACGTGGTCCCATCTGGATGAGGACCAGCAGGAGCTCAGCAGACAGCTGG
AGGTGGTGGAAAGCAGCATCCCAAGCGTGGGTCTGGTGGAGGAGAACGAGGACAGGCTTATTGACCGCATAACACTCTACCAGCATTTAA
AATCTAGCCTTAATGAATACCAGCCCAAATTATATCAAGTATTAGATGATGGGAAACGACTTCTGATATCCATCAGCTGCTCAGATCTAG
AAAGCCAACTAAATCAACTTGGAGAGTGCTGGCTAAGTAACACCAATAAAATGTCTAAGGAACTTCACAGACTGGAAACAATATTGAAAC
ACTGGACCAGATATCAAAGTGAATCTGCAGATCTAATTCACTGGTTACAATCTGCAAAAGACCGGCTAGAATTTTGGACTCAGCAATCTG
TGACAGTCCCACAAGAGCTGGAAATGGTCCGTGATCATCTAAATGCTTTCCTGGAGTTTTCTAAAGAAGTGGATGCCCAATCTTCCCTGA
AATCATCTGTTCTGAGTACTGGAAATCAGCTCCTTCGACTAAAAAAGGTGGACACAGCCACGCTGCGCTCTGAGCTGTCGCGCATTGATA
GCCAGTGGACTGACCTGCTAACCAATATCCCAGCCGTCCAGGAGAAGCTCCACCAGCTCCAGATGGATAAACTGCCTTCCCGCCATGCCA
TTTCTGAAGTCATGAGTTGGATTTCTCTAATGGAAAATGTTATTCAGAAGGATGAAGATAATATTAAAAATTCCATAGGTTACAAGGCAA
TTCATGAATACCTTCAGAAATATAAGGGTTTTAAGATAGACATTAACTGTAAACAGCTGACAGTGGATTTTGTGAACCAGTCCGTGCTAC
AAATCAGCAGTCAGGATGTGGAAAGTAAGCGTAGTGATAAGACTGATTTTGCTGAGCAACTTGGAGCAATGAATAAAAGTTGGCAAATTC
TGCAAGGTCTAGTAACTGAGAAGATCCAGCTGTTGGAAGGCTTATTGGAATCTTGGTCAGAATATGAAAATAATGTACAATGTCTGAAAA
CATGGTTTGAAACCCAGGAAAAGAGACTAAAACAACAGCATCGAATTGGAGATCAGGCTTCTGTTCAAAATGCACTGAAAGACTGTCAGG
ATCTGGAAGATTTGATTAAAGCAAAAGAAAAAGAAGTAGAGAAAATTGAGCAGAATGGACTTGCTTTGATTCAGAACAAGAAAGAAGACG
TCTCTAGCATTGTCATGAGCACACTGCGAGAGCTCGGCCAAACCTGGGCAAATTTAGATCACATGGTTGGACAATTAAAGATACTGCTGA
AATCAGTGCTTGACCAATGGAGTAGTCACAAAGTGGCCTTTGACAAGATAAACAGTTACCTCATGGAGGCCAGATACTCTCTTTCCCGAT
TCCGTCTGCTGACTGGCTCCTTAGAAGCTGTGCAAGTTCAGGTGGACAATCTTCAGAATCTCCAAGATGATCTGGAAAAACAGGAAAGGA
GCTTACAGAAATTTGGCTCTATCACCAACCAATTATTAAAAGAGTGTCACCCACCCGTGACAGAAACTCTTACCAATACACTGAAAGAAG
TCAACATGAGATGGAATAACTTGCTGGAAGAGATTGCTGAGCAGCTACAGTCCAGCAAGGCCCTACTTCAGCTTTGGCAAAGATACAAGG
ACTACTCCAAACAGTGTGCTTCGACAGTTCAGCAGCAGGAGGATCGAACCAATGAGCTGTTGAAGGCAGCCACAAACAAGGACATTGCCG
ATGATGAGGTTGCCACATGGATTCAAGATTGCAACGACCTCCTCAAAGGACTGGGCACAGTTAAAGATTCCCTCTTTTTTCTCCATGAGC
TGGGAGAGCAACTGAAGCAACAAGTGGATGCTTCCGCAGCATCAGCTATTCAATCGGATCAACTCTCTTTGAGTCAACACTTGTGTGCCC
TGGAGCAAGCTCTCTGCAAACAGCAGACTTCATTACAGGCTGGAGTTCTTGATTATGAAACCTTTGCCAAGAGTTTAGAAGCTTTGGAGG
CCTGGATAGTGGAAGCTGAAGAAATACTACAAGGGCAGGACCCTAGCCACTCATCTGACCTCTCCACAATCCAGGAAAGGATGGAAGAAC
TTAAGGGACAGATGTTAAAATTCAGCAGCATGGCTCCAGATTTAGACCGTCTAAATGAGCTTGGATATAGGTTACCCTTGAATGATAAGG
AAATCAAAAGAATGCAGAATCTGAACCGCCATTGGTCTCTGATCTCCTCTCAGACTACAGAAAGATTCAGCAAGTTGCAGTCATTTTTGC
TACAACATCAGACTTTCTTGGAAAAATGTGAAACATGGATGGAATTCCTAGTTCAGACAGAACAAAAGTTAGCAGTAGAGATTTCAGGAA
ATTATCAGCACCTTTTGGAACAGCAGAGAGCACACGAGTTGTTTCAAGCCGAGATGTTCAGTCGTCAGCAGATTTTGCACTCAATCATTA
TTGATGGGCAACGTCTTCTAGAACAAGGTCAAGTTGATGACAGGGATGAATTCAACCTGAAATTGACACTCCTCAGTAATCAATGGCAGG
GAGTGATTCGCAGGGCCCAGCAGAGGCGGGGGATCATTGACAGCCAGATTCGCCAGTGGCAGCGCTATAGGGAGATGGCAGAAAAGCTTC
GTAAATGGTTGGTTGAAGTGTCCTACCTCCCCATGAGTGGTCTCGGAAGTGTTCCTATACCACTGCAACAAGCAAGGACCCTCTTTGATG
AAGTGCAGTTCAAAGAAAAAGTGTTTCTGCGGCAACAAGGCAGCTACATCCTGACTGTGGAGGCTGGCAAGCAACTCCTTCTCTCGGCGG
ACAGTGGCGCTGAGGCCGCCTTGCAGGCCGAACTCGCTGAAATCCAAGAGAAATGGAAATCAGCCAGCATGCGGCTGGAAGAACAGAAGA
AAAAACTAGCCTTCTTGTTGAAAGACTGGGAAAAATGTGAGAAAGGAATAGCAGATTCCCTGGAGAAACTACGAACTTTCAAAAAGAAGC
TTTCGCAGTCTCTCCCGGATCACCATGAAGAGCTCCATGCAGAACAAATGCGTTGCAAGGAATTAGAAAATGCAGTTGGGAGCTGGACAG
ATGACTTGACCCAGTTGAGCCTGCTGAAGGACACCCTCTCTGCCTATATCAGTGCTGATGATATCTCCATTCTTAATGAACGCGTAGAGC
TTCTGCAAAGGCAGTGGGAAGAACTATGCCACCAGCTCTCCTTAAGGCGGCAGCAAATAGGTGAAAGATTGAATGAATGGGCAGTCTTCA
GTGAAAAGAACAAGGAACTCTGTGAGTGGTTGACTCAAATGGAAAGCAAAGTTTCTCAGAATGGAGACATTCTCATTGAAGAAATGATAG
AGAAGCTCAAGAAGGATTATCAAGAGGAAATTGCTATTGCTCAAGAGAACAAAATACAGCTCCAACAAATGGGAGAACGACTTGCTAAAG
CCAGCCATGAAAGCAAAGCATCTGAGATTGAATACAAGCTGGGAAAGGTCAACGACCGGTGGCAGCATCTCCTGGACCTCATTGCAGCCA
GGTCAGCTTTTGCCAACTGTTTTCAAATCACATGCATGGGGGATCTTACACACACTCCTTGAGATGTTTAGCTACCGGATGCATCATATT
CAGCCTCATTACAGAGTTCAGCTCCTGAGTCATCTTCATACTTTGGCTGCAGTTGCACAAACAAACCAGAACCAGCTCCATCTTTGTGTC
GAGAGCACTGCTCTCAGGCTTATAACAGCATTAGGTAGCTCAGAGGTACAACCGCAGTTTACACGCTTCCTTAGTGATCCCAAAACAGTG
CTCTCAGCAGAATCTGAAGAACTGAACCGAGCCTTGATATTGACCTTGGCTAGAGCAACTCATGTAACAGATTTTTTTACAGGCTCTGAT
TCAATTCAGGGAACTTGGTGTAAAGACATACTTCAGACCATCATGAGTTTCACTCCTCATAATTGGGCTTCACACACCCTGAGCTGTTTT
CCAGGCCCACTACAGGCATTCTTCAAACAAAATAATGTGCCTCAGGAAAGCCGTTTTAATCTGAAAAAAAATGTGGAGGAGGAGTATAGG
AAGTGGAAGTCAATGAGCAACGAAAACGACATTATTACCCACTTCTCTATGCAGGGCTCCCCTCCTCTCTTTCTTTGTCTTCTCTGGAAA
ATGCTCTTGGAAACAGATCATATTAATCAGATTGGCTATAGAGTATTAGAGAGAATTGGAGCCAGGGCCTTGGTAGCCCATGTGAGGACA
TTTGCAGATTTCCTGGTATATGAGTTTTCTACATCAGCAGGGGGTCAGCAACTCAATAAATGCATTGAAATTCTTAATGACATGGTATGG
AAGTATAACATTGTTACACTGGACAGATTAATTCTCTGCCTGGCCATGCGTAGTCACGAAGGAAATGAAGCCCAGGTTTGTTATTTCATA
ATTCAGTTGCTGTTACTCAAACCAAACGATTTTAGAAATCGAGTAAGTGACTTTGTGAAGGAAAATTCCCCAGAGCACTGGTTACAGAAT
GACTGGCACACCAAGCACATGAATTATCACAAGAAATATCCAGAGAAGTTGTATTTTGAGGGCCTCGCGGAACAGGTGGATCCTCCTGTA
CAGATCCAGTCTCCCTATCTGCCCATCTATTTTGGGAATGTGTGTCTTCGATTCCTTCCAGTATTTGATATAGTAATCCACAGATTTTTA
GAGTTGCTTCCGGTATCCAAATCACTGGAGACTCTACTGGATCATCTAGGAGGCTTATATAAATTTCATGATCGTCCAGTGACTTATCTG
TATAACACTCTGCACTATTATGAAATGCACCTGAGAGACCGCGCATTTCTCAAACGAAAACTCGTCCATGCGATCATTGGCTCTCTGAAG
GATAATCGACCGCAGGGCTGGTGTCTAAGTGACACTTACCTGAAATGCGCTATGAATGCACGAGAGGAAAATCCTTGGGTTCCAGATGAC
ACCTACTATTGCAGATTGATTGGCAGACTAGTCGATACGATGGCTGGCAAATCTCCTGGTCCCTTTCCAAACTGTGACTGGAGATTCAAT
GAGTTTCCCAACCCAGCTGCCCATGCTCTCCATGTTACTTGTGTGGAGCTCATGGCCTTGGCAGTTTCAGGCAAAGAAGTTGGGAATGCC
CTTCTAAATGTTGTCCTAAAAAGTCAGCCTTTAGTGCCAAGAGAGAACATTACAGCATGGATGAATGCAATTGGTTTGATCATCACTGCC
CTACCAGAGCCATATTGGATTGTTCTTCATGATCGAATTGTGAGTGTCATCAGCAGCCCCAGCTTGACGTCTGAAACAGAGTGGGTTGGC
TATCCATTCCGCCTCTTTGATTTCACTGCCTGTCATCAGTCCTACTCTGAGATGAGTTGTAGCTATACGTTAGCTCTTGCACATGCTGTG
TGGCACCATTCTAGCATCGGACAACTTTCTCTCATTCCAAAGTTTCTTACTGAAGTACTTCTTCCTATAGTGAAGACCGAATTCCAGTTG
CTTTATGTATACCATCTTGTTGGACCATTTTTACAAAGATTTCAGCAAGAGAGAACTCGTTGTATGATAGAGATTGGTGTGGCGTTTTAT
GACATGCTGCTGAATGTTGACCAGTGTAGCACCCATTTAAATTACATGGATCCCATCTGTGACTTCCTCTATCACATGAAGTATATGTTT
ACTGGTGACAGCGTGAAAGAGCAAGTAGAGAAGATTATCTGTAACTTAAAACCAGCTTTAAAACTTCGTCTTCGATTCATCACACACATT
AGCAAGATGGAGCCAGCTGCAGTGCCTCCACAAGCCATGAACAGTGGGTCTCCAGCACCTCAGTCTAATCAGTAAAAAGTCAGAGTACAC
AGCAAGGGTTCCAAATTAAGAGGAAGCAAAACGCTGCCCAGATCCTGAGAAACCTGGAGAAAATCAACCTTAGTAGTTTCAACTCATACA
TTGTCTTGTTTGATTTTGTTCTTTGTTTTTTATCCTCTTTAAGCACAGATGCGTGTTGAAGTCTAAGGTGTTCTGTCATCACACTCTCTT
TACTAGAATAAGTGTGCCCAGGCAGAAAAAAAAGTGTATTCAATGTTGCTGGCATGTGTGGATTCACAGCTCGTGGCTGTAAGGAAATCT

>88409_88409_1_SYNE1-MED23_SYNE1_chr6_152497529_ENST00000423061_MED23_chr6_131924344_ENST00000354577_length(amino acids)=7824AA_BP=7804
MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGRRMKRIHAVA
NIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVT
TKIQGNAKKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPEDVDV
DKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKH
FRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQ
RKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRR
ESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVA
SLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEY
TDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECY
SPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFD
QTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACD
ELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHL
CEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV
KRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSK
EVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWE
RFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDT
LEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIK
AKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFS
ASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQ
NEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSE
ISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGI
LRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEA
DALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRL
EVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL
SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESE
VKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQN
ETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFL
GAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDC
ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLT
SHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALR
SSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEA
EDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDS
SATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVA
QLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQ
ASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGI
QAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRL
KEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKL
EALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLN
ESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKA
FEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQF
NNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQ
SLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHME
QLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLE
LVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSL
EHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQK
LVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEI
NHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQK
MIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAIC
SELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREH
ICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDF
DKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKD
KFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDK
MLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLED
LAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQ
EEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGN
GLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKARE
EVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQD
QEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEP
PLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQ
KEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDG
CNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQ
LREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQA
QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYE
QYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDL
DGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS
QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEIL
MLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLS
TKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQ
GTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQE
LGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGG
AKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCL
LGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQ
VEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHM
ILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITL
YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFW
TQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLP
SRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNK
SWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQN
KKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLE
KQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATN
KDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSL
EALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKL
QSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLS
NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQL
LLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAV
GSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILI

--------------------------------------------------------------
>88409_88409_2_SYNE1-MED23_SYNE1_chr6_152497529_ENST00000423061_MED23_chr6_131924344_ENST00000368068_length(transcript)=27148nt_BP=23851nt
CGGCCGCCGGCCGCAGCGGGCTGAGATTGTTGTCCTCTGTCACCAGGGCGGCTGGGCTCCCGCAGTCCTGCAGACCGCGCCCGATCCCGG
CGACAGGGCGGGCGGACAGCCGCGCATCCCCGGGGTCCCGCCGAGCCTGGGCGCAGAGAGCCGGGAGGAAGCGTTCGCTCGCTTCGCCTT
GCTGCTGGGAAACTGAACGAGGCCGAGAGAGAAGGTTCTTGAGTTCATGTAAGAGGACAGTCTTAAAACGGAAGAAGAAAAAGAAGCAGT
TCAGTCTTTGGGAGAGCTGCCTCCTTGTTGAGTGCTGCAAAGGCCTGGAATTCATTTATGACAGAATAGATCTAGAAAAGTCCAAGCATG
TTTTCTAGAGTGGTGTAGCCCTGTGCTGCCTCCAGTGAAGAGTCTCTTGGTGTTGGCTTCGTGCTTCCGGAGGGACCATGGCAACCTCCA
GAGGGGCCTCCCGGTGTCCTCGGGATATCGCCAATGTGATGCAGAGGCTGCAAGATGAGCAAGAGATAGTACAAAAACGAACTTTCACAA
AATGGATCAACTCTCATCTGGCCAAGCGGAAACCTCCAATGGTGGTGGACGATCTTTTTGAAGACATGAAAGATGGTGTTAAACTGCTTG
CCCTTCTGGAGGTCCTGTCTGGGCAGAAACTGCCTTGTGAACAAGGACGCCGGATGAAGCGAATCCATGCTGTGGCTAACATTGGCACGG
CACTCAAGTTCCTCGAAGGAAGAAAGTCCATGCACAGAGGATCACCGATTAAATTAGTCAACATTAACTCCACCGATATAGCTGATGGCC
GACCCTCAATAGTTCTTGGATTGATGTGGACCATTATTCTATATTTCCAGATTGAAGAGTTGACCAGCAACCTGCCCCAGCTCCAGTCTT
TGTCCAGCAGCGCATCCTCCGTGGACAGCATAGTTAGCTCTGAGACTCCCAGCCCACCAAGTAAACGGAAGGTGACCACCAAGATCCAAG
GAAATGCTAAGAAGGCTTTATTAAAGTGGGTTCAGTACACAGCTGGCAAGCAGACTGGAATAGAAGTAAAAGATTTTGGGAAGAGTTGGA
GAAGCGGGGTTGCCTTTCATTCAGTTATTCATGCCATTCGACCGGAATTGGTGGACTTGGAGACAGTGAAAGGCAGATCCAACCGAGAAA
ATTTGGAGGATGCTTTCACTATCGCCGAAACAGAACTGGGGATCCCAAGACTGCTAGATCCTGAAGACGTTGATGTGGATAAACCAGATG
AGAAATCTATTATGACCTATGTAGCCCAGTTTCTGAAACATTATCCTGACATCCACAATGCAAGCACTGATGGGCAAGAGGATGATGAAA
TACTTCCAGGTTTCCCATCTTTTGCAAATTCTGTACAAAATTTTAAGAGAGAAGACAGAGTAATTTTTAAGGAAATGAAAGTTTGGATAG
AACAATTTGAGAGAGATTTGACAAGAGCACAGATGGTGGAATCAAATTTACAGGATAAATATCAGTCATTTAAGCACTTCAGAGTTCAAT
ATGAAATGAAGAGGAAACAGATTGAACATTTAATACAACCATTACACAGAGACGGTAAATTGTCACTTGACCAAGCATTGGTAAAACAAT
CTTGGGATAGAGTGACCTCCAGGCTCTTTGACTGGCATATACAGCTTGATAAATCTCTTCCTGCACCTCTGGGCACCATAGGTGCCTGGC
TGTACAGAGCGGAGGTGGCCCTGAGAGAGGAAATAACCGTTCAACAGGTCCACGAGGAAACAGCAAACACGATACAACGGAAACTTGAGC
AACATAAGGATCTGCTTCAAAACACGGATGCCCACAAAAGAGCATTCCATGAAATCTACCGGACCAGGTCTGTTAACGGGATTCCAGTGC
CACCTGATCAATTAGAGGACATGGCCGAGAGGTTTCATTTTGTTTCCTCCACATCAGAGCTACACCTAATGAAAATGGAATTTTTAGAAT
TAAAGTACCGTCTGCTCTCACTGCTGGTTCTTGCAGAGTCAAAGCTGAAGTCTTGGATCATTAAGTACGGGAGGAGAGAGTCAGTGGAGC
AGCTTCTACAAAACTACGTGTCTTTTATAGAAAATAGCAAGTTCTTTGAACAATATGAGGTGACATACCAGATCTTGAAACAGACAGCTG
AGATGTATGTCAAAGCAGATGGTTCAGTGGAAGAAGCTGAGAATGTGATGAAATTCATGAATGAAACCACCGCTCAGTGGAGGAATCTCT
CAGTAGAAGTGAGGAGTGTGAGGAGCATGCTGGAAGAAGTGATCTCTAACTGGGATCGCTATGGCAATACAGTGGCTAGTCTGCAAGCCT
GGCTAGAGGATGCTGAAAAAATGCTCAATCAATCAGAAAATGCCAAAAAGGATTTTTTTCGAAATTTACCTCATTGGATTCAGCAGCATA
CTGCCATGAACGATGCTGGCAATTTTCTAATTGAAACCTGTGATGAGATGGTTTCCCGTGACCTGAAGCAGCAATTACTGTTGCTAAATG
GGCGGTGGAGGGAGTTGTTTATGGAAGTCAAGCAATATGCTCAAGCTGATGAGATGGACAGAATGAAGAAGGAATACACAGACTGTGTTG
TTACCCTGTCTGCTTTTGCAACGGAAGCCCATAAGAAACTTTCTGAACCCTTAGAAGTCTCTTTTATGAATGTCAAGCTATTAATTCAAG
ACTTGGAGGATATTGAGCAGAGGGTGCCTGTGATGGATGCCCAATACAAGATAATTACAAAGACAGCACACCTCATTACCAAAGAAAGCC
CCCAAGAAGAAGGAAAAGAAATGTTTGCGACCATGTCAAAGCTCAAAGAGCAGCTAACCAAGGTCAAAGAATGTTACTCCCCACTCCTTT
ATGAGTCTCAGCAGCTGTTGATTCCGTTGGAGGAATTAGAAAAGCAGATGACGTCCTTTTATGACTCACTTGGGAAAATCAATGAAATTA
TCACAGTTCTTGAGCGTGAGGCACAATCGAGTGCCCTTTTTAAACAAAAACATCAGGAACTGTTAGCTTGTCAAGAAAACTGTAAGAAAA
CCTTGACACTTATTGAGAAAGGCAGTCAAAGTGTTCAAAAGTTTGTGACCTTGAGCAACGTGTTAAAGCATTTTGATCAGACGAGGCTAC
AAAGACAGATTGCAGATATTCATGTTGCTTTTCAGAGTATGGTAAAGAAAACTGGAGATTGGAAGAAGCATGTGGAAACCAACAGTCGCT
TGATGAAGAAGTTTGAGGAGTCTCGAGCAGAGTTGGAGAAGGTACTGCGGATTGCTCAGGAGGGCCTGGAGGAAAAGGGGGATCCAGAGG
AGCTCCTGCGGAGACACACTGAGTTTTTCAGTCAGCTGGATCAGAGGGTGCTCAATGCTTTCCTGAAAGCTTGTGATGAACTCACCGACA
TCCTTCCAGAGCAGGAGCAGCAGGGGCTGCAGGAAGCTGTTCGAAAGCTCCACAAACAATGGAAGGATCTTCAAGGAGAAGCCCCTTATC
ATTTGCTTCATCTGAAGATTGATGTGGAGAAGAATAGGTTCTTAGCCTCTGTAGAAGAATGCAGAACTGAGCTGGATCGAGAGACCAAGC
TGATGCCCCAGGAAGGCAGTGAAAAGATAATTAAAGAGCACAGGGTTTTCTTCAGTGACAAAGGTCCTCATCATCTCTGTGAGAAAAGGT
TACAGCTCATCGAGGAACTCTGTGTGAAACTCCCAGTGCGGGACCCAGTAAGGGACACACCTGGAACCTGTCACGTGACTCTCAAAGAGC
TCAGAGCTGCCATTGACAGCACCTACAGGAAGCTCATGGAAGACCCAGACAAGTGGAAGGACTACACTAGCAGATTCTCTGAGTTCTCAT
CTTGGATATCTACAAATGAGACACAATTAAAGGGGATCAAGGGTGAGGCCATCGATACTGCCAACCACGGAGAGGTTAAACGTGCCGTTG
AAGAGATCAGAAATGGTGTTACCAAAAGGGGTGAGACCCTCAGCTGGCTGAAATCCAGGCTGAAAGTTTTGACAGAAGTTTCTTCTGAGA
ATGAAGCCCAAAAGCAGGGAGATGAGCTGGCAAAATTATCCAGCTCTTTCAAGGCTCTTGTGACGCTGCTGTCAGAGGTTGAAAAGATGC
TAAGCAATTTTGGGGACTGTGTCCAGTACAAAGAAATAGTCAAAAATTCTCTCGAAGAATTAATTTCTGGCTCTAAAGAAGTCCAGGAAC
AAGCTGAGAAGATCTTGGATACTGAAAATCTGTTTGAAGCACAGCAGTTACTTCTTCATCACCAGCAAAAGACAAAGCGGATCTCAGCAA
AGAAGAGAGATGTGCAGCAGCAGATCGCGCAGGCGCAGCAGGGAGAAGGGGGGCTGCCTGACCGAGGCCACGAGGAGCTGCGGAAGCTGG
AGAGCACACTGGATGGCCTGGAGCGCAGCCGGGAGAGGCAGGAACGCCGCATCCAGGTCACATTAAGAAAATGGGAGCGATTTGAAACAA
ACAAAGAAACAGTAGTAAGATACCTTTTTCAAACAGGTTCCAGTCATGAACGCTTCTTGAGTTTTAGCAGTTTGGAAAGTTTATCTTCAG
AACTGGAACAAACAAAGGAGTTTTCTAAACGGACAGAAAGTATTGCAGTCCAGGCTGAGAACCTTGTAAAGGAAGCTTCAGAGATACCGC
TTGGGCCCCAAAATAAGCAGCTGCTTCAACAGCAGGCCAAGTCAATCAAAGAACAAGTCAAAAAATTAGAAGACACGCTTGAAGAAGATA
TTAAAACCATGGAAATGGTGAAAACCAAGTGGGATCATTTTGGCAGTAATTTTGAGACTCTGTCCGTCTGGATAACTGAGAAAGAAAAAG
AACTCAATGCCTTGGAAACTTCGTCATCTGCCATGGACATGCAAATCAGCCAAATTAAGGTCACAATTCAGGAAATAGAAAGTAAGCTCA
GCAGCATTGTAGGATTAGAAGAAGAAGCCCAGTCTTTTGCTCAGTTTGTTACCACTGGAGAATCTGCTCGAATTAAAGCCAAGTTGACAC
AAATAAGAAGATACGGGGAAGAGCTTCGAGAGCATGCACAGTGTCTGGAAGGAACAATCCTGGGACATTTATCTCAGCAGCAAAAGTTTG
AAGAGAACCTTAGAAAGATCCAGCAATCTGTGTCTGAATTTGAAGATAAACTTGCTGTTCCAATTAAAATATGTTCTTCAGCTACAGAAA
CATACAAAGTTCTTCAAGAACATATGGATCTCTGCCAGGCCCTGGAGTCACTGAGCAGCGCGATCACTGCCTTCTCAGCCAGTGCCAGGA
AGGTTGTGAACAGAGATTCCTGTGTTCAGGAGGCTGCGGCTCTACAGCAGCAATACGAGGACATCCTAAGGAGGGCGAAGGAGAGACAGA
CGGCGCTGGAGAATCTGCTGGCCCACTGGCAGAGGCTAGAGAAAGAACTATCATCCTTTTTGACCTGGTTAGAGCGGGGTGAAGCTAAAG
CCAGTTCCCCAGAAATGGACATTTCTGCAGACAGAGTCAAAGTGGAAGGTGAACTTCAGTTAATACAGGCACTGCAAAATGAAGTTGTAT
CCCAGGCCTCATTCTATAGCAAACTTTTGCAATTGAAGGAATCATTGTTCTCAGTAGCCTCCAAAGATGATGTGAAAATGATGAAACTAC
ATTTGGAGCAGTTGGATGAGAGATGGAGAGATTTACCACAGATCATTAACAAAAGGATTAATTTTCTTCAGTCTGTGGTTGCTGAACACC
AGCAATTTGATGAGCTGCTGCTTTCCTTTTCTGTCTGGATTAAACTGTTTCTCAGTGAATTACAAACTACCTCTGAGATTAGCATAATGG
ACCATCAAGTAGCCCTTACTCGGCATAAGGACCACGCAGCAGAAGTAGAGAGCAAAAAGGGCGAATTGCAGAGTCTGCAGGGTCACTTAG
CAAAGTTGGGTTCTCTGGGCCGTGCTGAGGACCTCCACCTCCTGCAGGGAAAGGCTGAGGACTGCTTCCAGCTGTTTGAGGAGGCCAGCC
AGGTTGTGGAGAGGCGGCAGCTTGCCCTGTCCCATTTGGCAGAATTCCTCCAGAGCCATGCCTCTCTGTCCGGCATTCTCCGCCAGCTGA
GGCAAACAGTGGAAGCAACCAACAGTATGAATAAGAACGAGTCTGATTTGATAGAAAAGGACCTCAATGATGCTCTTCAAAATGCTAAAG
CATTAGAATCTGCTGCCGTCAGTCTGGATGGCATTCTTTCCAAAGCCCAATACCATCTGAAAATCGGGAGCTCTGAGCAAAGGACTTCCT
GCAGAGCCACGGCTGATCAGCTCTGTGGAGAGGTAGAGAGGATCCAGAACCTTCTGGGAACCAAGCAGAGTGAGGCAGATGCTCTGGCAG
TGTTGAAAAAAGCATTCCAAGACCAGAAAGAGGAGCTTCTGAAAAGCATTGAGGACATTGAAGAAAGGACTGACAAAGAGCGATTGAAAG
AACCTACCCGCCAAGCTCTTCAGCAGAGGTTAAGAGTGTTTAATCAGCTAGAAGATGAATTGAATTCTCACGAGCATGAACTATGTTGGT
TGAAAGACAAAGCCAAGCAAATTGCCCAGAAAGATGTAGCTTTTGCACCTGAAGTTGACAGGGAGATAAACCGCTTAGAGGTCACCTGGG
ATGATACCAAAAGACTAATTCATGAAAATCAGGGTCAGTGCTGTGGACTTATTGACTTAATGAGAGAATATCAGAACCTGAAATCAGCTG
TATCTAAAGTCTTAGAAAATGCCAGCAGTGTGATTGTAACCAGAACTACCATAAAAGATCAGGAGGATCTTAAATGGGCTTTTTCCAAGC
ATGAAACTGCCAAGAACAAAATGAATTACAAACAGAAAGACTTGGATAACTTTACCAGCAAAGGAAAACACTTGTTATCTGAGCTGAAGA
AAATTCACAGTAGTGATTTCAGCTTGGTGAAAACAGACATGGAGAGCACCGTGGACAAATGGCTGGATGTATCAGAGAAACTTGAAGAAA
ACATGGATAGGCTGAGAGTAAGCCTGTCCATTTGGGATGATGTACTGTCAACTAGAGATGAGATTGAGGGATGGTCAAACAACTGCGTTC
CACAGATGGCAGAAAACATCAGCAACCTGGATAACCACCTCAGAGCTGAAGAACTGCTTAAAGAATTTGAGTCTGAAGTTAAAAACAAAG
CATTGAGATTGGAAGAACTGCATTCCAAAGTTAATGATCTGAAAGAATTAACTAAAAATCTAGAAACACCGCCAGACCTTCAGTTTATAG
AAGCAGACTTAATGCAGAAACTGGAGCATGCCAAAGAAATAACTGAAGTAGCAAAAGGAACCCTGAAGGATTTCACGGCTCAAAGTACAC
AAGTGGAGAAGTTTATTAATGACATAACAACATGGTTCACAAAAGTGGAAGAATCGTTGATGAACTGTGCCCAAAATGAGACTTGTGAAG
CATTGAAAAAAGTCAAGGATATACAAAAAGAACTTCAAAGTCAACAAAGCAACATCAGCTCTACCCAAGAAAATCTCAATAGCTTGTGCC
GCAAGTACCACTCAGCTGAGTTGGAGAGCCTGGGCCGTGCAATGACTGGTCTGATAAAGAAACATGAAGCCGTGAGCCAGTTGTGCTCCA
AAACCCAGGCCAGCCTGCAGGAATCTCTGGAAAAACACTTCAGTGAGTCTATGCAGGAATTCCAAGAATGGTTTTTGGGAGCAAAGGCAG
CAGCAAAAGAATCATCAGATCGCACCGGTGACAGCAAAGTTCTAGAAGCAAAGCTCCATGATCTTCAGAACATTTTGGACTCAGTCAGTG
ATGGGCAGAGCAAACTTGATGCAGTGACTCAAGAAGGACAAACTTTGTATGCACATTTGTCTAAACAAATTGTCAGTAGCATTCAAGAAC
AAATCACAAAGGCCAATGAAGAGTTTCAAGCATTTCTGAAACAATGCCTTAAAGATAAGCAGGCTCTTCAAGACTGTGCTTCAGAACTTG
GAAGCTTTGAAGATCAGCACAGAAAACTGAACTTATGGATCCATGAAATGGAAGAAAGGTTCAATACGGAAAACTTGGGAGAGAGTAAAC
AGCACATTCCTGAGAAGAAAAATGAAGTTCATAAAGTTGAAATGTTTTTGGGAGAACTGCTGGCTGCAAGAGAGTCTCTTGATAAGCTTT
CCCAGAGAGGGCAGCTTCTGAGTGAAGAAGGCCACGGTGCTGGGCAGGAGGGCCGCCTGTGTTCCCAGCTCCTCACAAGCCACCAGAACC
TACTTAGAATGACCAAAGAGAAACTCCGGAGCTGCCAGGTGGCCCTTCAGGAGCACGAAGCCCTGGAGGAAGCACTGCAAAGCATGTGGT
TCTGGGTGAAGGCCATTCAGGACAGACTGGCCTGTGCAGAGAGCACTCTTGGGAGCAAAGACACCCTGGAGAAACGGCTGTCACAAATAC
AGGATATTCTCCTGATGAAAGGTGAAGGGGAAGTTAAGTTGAATATGGCCATTGGCAAGGGGGAACAGGCCTTGAGAAGTAGCAACAAAG
AAGGTCAGAGGGTGATTCAGACTCAGTTAGAGACCCTTAAAGAAGTGTGGGCTGACATCATGAGCTCCTCCGTCCACGCTCAAAGCACTT
TAGAGTCTGTGATTAGCCAATGGAATGACTATGTAGAGAGGAAAAACCAGTTGGAGCAGTGGATGGAATCAGTGGATCAAAAAATAGAAC
ATCCCTTACAACCACAGCCAGGTCTGAAAGAGAAGTTCGTCCTGCTTGACCACCTCCAGTCCATCCTGTCTGAGGCAGAAGATCACACGA
GAGCCCTTCACCGTCTAATTGCGAAGTCCAGGGAGCTCTACGAAAAGACAGAGGATGAGTCTTTCAAGGACACAGCTCAAGAGGAGCTGA
AAACACAGTTTAATGATATAATGACTGTTGCCAAGGAAAAAATGAGGAAAGTGGAAGAGATTGTGAAAGATCATCTAATGTATTTAGATG
CGGTCCACGAGTTCACAGATTGGCTCCATTCAGCAAAGGAAGAACTTCACCGGTGGTCAGATATGTCTGGAGATTCATCAGCCACCCAGA
AAAAGTTATCAAAAATTAAGGAGCTGATAGATTCCAGAGAGATTGGTGCAAGCCGTCTCAGCAGAGTGGAGTCGCTGGCTCCCGAAGTGA
AACAGAACACAACTGCCAGTGGGTGTGAGCTCATGCACACGGAGATGCAGGCCCTGCGTGCCGACTGGAAGCAGTGGGAAGACAGTGTAT
TCCAAACGCAGAGCTGTTTGGAGAACCTGGTCAGCCAGATGGCCCTTTCGGAGCAGGAATTCTCAGGCCAAGTGGCTCAACTGGAGCAGG
CCCTGGAACAGTTCAGTGCCCTTCTGAAAACCTGGGCTCAGCAGTTAACCCTCCTGGAAGGCAAGAACACGGATGAGGAGATAGTGGAAT
GCTGGCACAAAGGACAAGAGATACTGGATGCTTTGCAAAAAGCAGAGCCTAGAACAGAGGATCTCAAGTCTCAGCTGAATGAACTTTGTC
GATTTTCCAGAGACCTGAGTACCTACAGTGGAAAAGTTTCTGGCTTGATTAAAGAGTATAATTGTCTTTGTTTGCAAGCATCCAAGGGCT
GCCAGAATAAAGAACAGATTTTACAGCAAAGATTTCGAAAGGCCTTCAGGGATTTCCAGCAGTGGTTGGTTAATGCAAAAATCACTACCG
CCAAGTGTTTTGATATACCTCAAAATATAAGTGAAGTTTCAACTAGTCTTCAGAAAATACAGGAGTTTTTGTCAGAAAGTGAAAATGGAC
AGCACAAGCTAAACATGATGCTGTCTAAAGGGGAACTTCTGAGTACCCTGCTGACCAAAGAGAAAGCGAAAGGGATCCAGGCCAAAGTTA
CAGCTGCAAAAGAAGATTGGAAAAATTTTCATTCAAATCTCCACCAAAAAGAATCTGCTCTAGAGAATCTAAAGATCCAAATGAAGGACT
TTGAAGTAAGTGCTGAGCCTATCCAGGACTGGCTGAGTAAAACTGAGAAGATGGTCCATGAAAGCAGCAATCGCCTCTATGATCTGCCAG
CAAAGAGGAGGGAGCAGCAGAAGCTCCAGTCTGTCCTTGAGGAAATACACTGCTACGAGCCTCAGCTCAACAGGCTGAAAGAGAAAGCTC
AGCAGCTGTGGGAAGGACAAGCTGCCAGCAAGAGCTTTAGGCACAGAGTGTCGCAGCTGTCTTCTCAGTATCTAGCGCTAAGCAATTTAA
CAAAGGAGAAAGTGTCAAGACTGGATAGAATCGTTGCAGAACACAATCAGTTCTCTCTTGGGATTAAAGAATTACAAGACTGGATGACGG
ATGCGATTCACATGCTGGATTCATACTGCCACCCGACATCCGACAAAAGTGTGCTGGACAGCAGGACGCTCAAGCTCGAGGCTCTATTAT
CAGTCAAACAGGAAAAAGAGATTCAGATGAAAATGATAGTGACCAGGGGAGAATCTGTCCTTCAGAATACTTCTCCAGAAGGCATTCCCA
CTATTCAGCAGCAGCTGCAGAGTGTGAAGGATATGTGGGCATCCCTTTTGTCTGCAGGGATTCGTTGTAAAAGCCAACTCGAAGGAGCTC
TCTCCAAGTGGACAAGTTATCAGGATGGCGTTCGACAGTTCTCCGGTTGGATGGATAGTATGGAAGCCAACCTGAATGAATCAGAAAGGC
AGCATGCGGAGCTGCGGGATAAAACAACGATGCTCGGAAAAGCCAAGTTATTAAATGAAGAAGTGCTGAGTTACAGCAGCTTGCTGGAGA
CCATCGAAGTCAAAGGGGCTGGCATGACAGAACACTATGTCACCCAGCTAGAACTCCAGGATCTACAGGAACGATACAGAGCCATCCAAG
AGAGGGCCAAGGAAGCCGTAACCAAGTCTGAAAAACTTGTCCGCCTGCACCAAGAGTATCAGAGAGACCTAAAGGCATTTGAAGTTTGGT
TGGGGCAAGAACAAGAAAAGCTCGACCAGTATTCAGTTCTTGAAGGTGATGCCCACACTCATGAGACAACATTGCGTGATCTTCAGGAGC
TACAGGTACACTGTGCAGAGGGGCAGGCCCTGTTGAACTCAGTGCTGCACACCAGAGAGGATGTGATCCCATCAGGTATCCCACAGGCAG
AGGACCGGGCTTTAGAGTCTCTCCGGCAAGACTGGCAGGCTTACCAGCACAGGCTGTCCGAGACTCGAACTCAGTTCAATAACGTGGTGA
ACAAATTGAGGCTAATGGAGCAAAAGTTTCAGCAAGTAGATGAATGGCTCAAAACAGCAGAGGAGAAAAAGTGGCACGAAGAAGTGACTG
CATACAGAGATGAAGTTGAGGAAGTGGGAGCTAGAGCTCAGGAGATACTGGACGAGAGCCACGTGAACAGCAGAATGGGTTGCCAGGCCA
CCCAGCTGACTTCCAGATACCAGGCCCTGCTTCTCCAAGTGCTGGAACAAATAAAATTCCTGGAGGAGGAGATTCAGAGTTTGGAGGAAT
CAGAATCATCCCTCAGTTCCTATTCTGATTGGTATGGCTCTACTCATAAAAACTTCAAGAATGTGGCTACCAAGATTGACAAAGTAGATA
CAGTAATGATGGGGAAGAAATTGAAGACGTTGGAGGTTTTGCTCAAAGACATGGAGAAAGGTCACAGTTTGCTGAAATCAGCCCGGGAGA
AAGGAGAGAGGGCTGTTAAATACTTGGAGGAAGGCGAGGCAGAGAGGTTAAGAAAGGAGATTCATGATCACATGGAGCAGTTGAAGGAAC
TGACCAGCACTGTCCGGAAAGAACACATGACGCTGGAAAAAGGTCTTCATTTAGCAAAGGAATTCTCAGATAAATGCAAAGCACTGACAC
AGTGGATAGCAGAATACCAGGAAATTCTACATGTTCCTGAAGAACCCAAAATGGAATTATATGAGAAAAAAGCTCAGTTATCTAAATACA
AGTCACTTCAACAAACGGTGCTGTCCCATGAACCATCAGTAAAGTCAGTGAGAGAGAAGGGTGAAGCTCTTTTGGAACTGGTGCAGGACG
TCACTTTAAAGGACAAAATAGATCAACTTCAAAGTGATTACCAGGACCTGTGCAGCATAGGAAAGGCAATGATGGAAGAAATTGCTGGTT
TTGAAGACCGTTTGAACAATCTTCAAATGAAAGGTGATACTTTGATTGGCCAATGTGCAGACCACCTGCAAGCGAAACTTAAACAAAACG
TGCATGCTCATCTGCAGGGCACAAAGGACAGCTACTCAGCGATCTGCAGCACAGCTCAGAGGATGTACCAGAGTTTGGAACACGAACTTC
AGAAGCACGTCAGCCGACAAGACACCCTGCAGCAGTGCCAGGCCTGGCTTTCTGCAGTCCAGCCGGATTTAGAGCCAAGTCCTCAACCAC
CTCTTAGTAGGGCAGAAGCCATTAAGCAGGTCAAACACTTCAGAGCTTTGCAAGAGCAGGCAAGGACCTACCTAGATCTCCTTTGCTCCA
TGTGTGACCTGTCAAATGCTTCGGTGAAAACCACAGCAAAAGACATTCAACAAACAGAGCAAACGATTGAACAAAAGCTTGTCCAGGCCC
AGAACTTAACTCAGGGCTGGGAAGAGATCAAGCACCTGAAGTCTGAGCTCTGGATTTACCTGCAAGATGCTGATCAGCAACTGCAGAACA
TGAAGAGGAGGCACTCTGAGCTGGAGCTGAACATTGCACAGAACATGGTTTCACAAGTTAAGGATTTTGTTAAGAAACTACAGAGCAAAC
AGGCATCCGTGAACACCATAATAGAAAAGGTGAATAAGTTAACAAAGAAGGAGGAATCGCCTGAACACAAGGAAATAAATCATTTAAATG
ATCAGTGGCTCGATTTGTGCCGTCAGTCTAACAACCTGTGCTTGCAAAGGGAAGAGGATCTTCAGAGAACAAGAGATTACCATGACTGTA
TGAATGTTGTTGAAGTGTTCCTAGAAAAATTTACTACAGAATGGGATAACTTGGCCAGATCTGATGCAGAGAGTACAGCTGTCCACCTGG
AAGCTTTGAAAAAGTTAGCATTGGCATTGCAGGAGAGAAAGTATGCTATTGAAGATCTGAAAGATCAAAAGCAGAAAATGATAGAGCATC
TGAATTTAGATGACAAGGAGTTAGTCAAAGAACAGACGAGTCATTTAGAGCAACGTTGGTTTCAGCTTGAGGACCTCATTAAAAGGAAAA
TCCAAGTGTCAGTCACCAACTTGGAGGAGTTAAATGTGGTGCAGTCCAGATTTCAGGAGCTAATGGAGTGGGCAGAAGAGCAACAACCCA
ACATCGCCGAGGCCCTTAAGCAGAGCCCTCCTCCAGATATGGCTCAGAACCTTCTCATGGATCACCTGGCCATCTGCAGTGAACTGGAGG
CCAAGCAGATGCTCCTGAAATCGCTTATAAAGGACGCAGACAGGGTCATGGCAGATCTTGGTCTCAATGAGCGACAGGTCATCCAGAAGG
CTCTCTCTGATGCACAAAGCCACGTGAATTGTCTCAGTGACTTAGTGGGCCAGCGAAGAAAGTACTTAAACAAAGCCTTGTCCGAGAAAA
CCCAGTTTCTCATGGCAGTGTTCCAGGCCACCAGCCAAATTCAGCAACATGAGCGAAAGATAATGTTCCGTGAACACATCTGTCTGTTAC
CAGATGATGTGAGCAAACAAGTCAAAACATGTAAGAGTGCACAAGCCAGCCTCAAGACTTACCAAAATGAAGTCACTGGACTTTGGGCCC
AGGGTCGCGAACTAATGAAGGAAGTCACAGAGCAGGAAAAGAGTGAAGTGCTGGGGAAGCTTCAGGAATTGCAGAGTGTCTATGACAGTG
TTTTACAAAAGTGCAGTCACCGGTTACAAGAACTAGAGAAGAATTTGGTTTCTAGGAAGCATTTTAAGGAAGATTTTGATAAAGCTTGCC
ACTGGCTAAAACAAGCAGATATTGTTACATTTCCTGAAATCAACCTAATGAATGAGAGTTCTGAGCTTCATACACAACTGGCTAAATACC
AAAACATTCTTGAACAATCTCCAGAATATGAAAATCTTCTACTTACGCTGCAGAGAACTGGGCAGACCATATTACCATCGCTGAATGAAG
TCGATCATTCCTACCTCAGTGAAAAGCTAAATGCTTTGCCTCGACAATTTAATGTAATTGTTGCCTTGGCTAAAGACAAGTTCTATAAAG
TCCAGGAAGCAATTCTTGCTCGGAAGGAATATGCTTCCTTGATTGAGTTGACAACCCAGTCTCTGAGTGAACTTGAAGCCCAATTCTTGA
GGATGAGCAAAGTTCCCACCGACCTGGCCGTTGAGGAGGCTCTTTCTCTGCAAGATGGTTGCAGAGCCATTCTGGACGAGGTGGCGGGCC
TTGGGGAGGCGGTGGATGAACTGAACCAGAAAAAAGAAGGTTTTCGCAGCACAGGTCAGCCTTGGCAGCCAGACAAGATGCTGCACCTTG
TCACCTTATATCACAGGCTGAAGCGACAAACAGAACAGAGGGTTAGCTTATTAGAAGACACCACCAGTGCTTACCAAGAACACGAGAAGA
TGTGCCAACAGCTGGAGAGACAACTGAAGTCTGTAAAAGAGGAGCAGTCCAAAGTGAATGAGGAAACGCTGCCTGCAGAGGAGAAGCTCA
AAATGTATCACTCCCTGGCAGGAAGTCTCCAGGACTCAGGGATTGTACTGAAACGAGTAACCATACATCTTGAAGATCTTGCCCCACACC
TTGACCCCTTGGCTTATGAGAAAGCCAGGCATCAGATCCAGTCCTGGCAAGGGGAGTTAAAACTGTTGACTTCTGCCATTGGTGAGACGG
TGACAGAATGTGAGAGCCGAATGGTGCAGAGTATAGACTTCCAGACTGAGATGAGTCGCTCCCTGGACTGGCTGAGGAGAGTGAAGGCAG
AGCTCAGTGGGCCGGTGTACCTAGACCTCAACCTGCAGGACATCCAAGAGGAAATCAGAAAAATCCAAATTCATCAGGAAGAGGTCCAGT
CCAGCTTGAGAATCATGAATGCGCTGAGTCACAAGGAAAAGGAGAAGTTCACAAAGGCCAAGGAGCTGATTTCTGCGGATTTAGAACACA
GCCTCGCTGAGCTCTCAGAGCTGGATGGAGACATCCAGGAAGCCTTACGCACCAGACAGGCTACCTTGACTGAAATATATAGCCAGTGTC
AAAGGTATTATCAGGTATTTCAAGCAGCCAATGACTGGCTTGAGGATGCCCAAGAATTGTTACAGCTGGCAGGCAATGGCCTAGACGTGG
AGAGCGCAGAGGAAAATCTCAAAAGCCACATGGAATTTTTCAGTACAGAGGATCAGTTCCATAGTAACCTGGAGGAGCTCCACAGCCTGG
TAGCCACCCTGGACCCACTCATCAAGCCAACCGGCAAAGAAGACCTAGAACAGAAAGTGGCTTCTCTGGAACTCAGGAGCCAGAGGATGA
GCCGGGACTCTGGTGCCCAAGTGGATCTCTTGCAGAGATGCACAGCTCAATGGCACGATTACCAGAAAGCAAGGGAAGAGGTTATTGAAT
TGATGAATGATACAGAAAAGAAATTGTCTGAGTTTTCTTTGTTGAAGACTTCGTCTAGTCATGAAGCGGAAGAAAAATTGTCAGAACACA
AGGCTTTAGTGTCAGTGGTTAACTCTTTCCATGAGAAAATTGTGGCCCTTGAGGAAAAAGCTTCACAACTGGAGAAAACCGGAAATGATG
CCAGCAAAGCCACCCTGAGCAGGTCAATGACCACCGTCTGGCAGCGCTGGACACGCCTTCGAGCTGTGGCCCAGGACCAGGAGAAGATCC
TGGAAGATGCAGTGGATGAGTGGACGGGCTTTAACAACAAGGTTAAAAAGGCCACTGAAATGATTGATCAGCTGCAAGATAAGTTACCTG
GAAGTTCAGCAGAGAAAGCATCGAAAGCAGAGCTCTTAACTCTTCTTGAATACCACGACACGTTCGTTCTGGAGCTGGAGCAGCAGCAGT
CGGCCTTGGGCATGCTGCGGCAGCAAACCCTGAGCATGCTCCAGGATGGAGCCGCCCCAACCCCTGGGGAAGAGCCTCCGCTCATGCAGG
AAATCACCGCCATGCAAGATCGGTGCCTGAACATGCAGGAGAAAGTGAAGACTAATGGAAAGTTGGTGAAGCAAGAGCTGAAGGACCGAG
AAATGGTGGAGACTCAGATCAATTCTGTGAAATGTTGGGTTCAGGAAACGAAAGAATATTTAGGGAATCCAACAATAGAAATAGATGCTC
AACTTGAAGAACTTCAGATTCTCCTAACAGAAGCCACAAATCACCGACAGAACATTGAAAAAATGGCAGAAGAACAGAAGGAGAAGTACT
TAGGTCTTTATACCATATTACCTTCTGAACTCTCCCTTCAGTTGGCTGAAGTGGCGTTAGATCTAAAGATCCGAGATCAGATCCAAGACA
AAATAAAAGAAGTTGAGCAGAGCAAGGCCACGAGCCAGGAACTCAGCCGGCAAATTCAGAAGTTAGCTAAAGACCTCACAACTATTCTAA
CTAAGCTGAAAGCGAAGACAGATAATGTAGTTCAAGCTAAAACTGACCAAAAGGTGCTGGGAGAGGAATTAGATGGCTGTAATTCAAAGT
TAATGGAATTAGATGCAGCAGTACAGAAATTCTTGGAACAGAATGGCCAACTGGGTAAGCCACTGGCCAAGAAGATAGGAAAACTGACTG
AACTTCACCAGCAGACCATTAGACAAGCTGAGAATCGGCTCTCCAAGCTCAATCAGGCAGCATCACATTTAGAAGAATACAATGAAATGC
TTGAATTAATTTTGAAGTGGATTGAAAAAGCTAAAGTCTTGGCTCATGGAACTATTGCATGGAATTCTGCAAGCCAGCTTCGGGAACAAT
ATATTTTGCATCAGACCCTGCTAGAAGAATCCAAAGAAATTGACAGTGAGCTGGAAGCAATGACTGAGAAATTACAGTACCTCACTAGCG
TGTACTGTACAGAAAAAATGTCTCAGCAAGTGGCAGAACTGGGACGGGAGACTGAGGAGTTGCGACAGATGATCAAAATTCGTTTGCAGA
ACCTCCAAGATGCAGCTAAGGATATGAAAAAATTTGAAGCAGAGTTGAAAAAGTTACAAGCTGCCTTGGAGCAAGCCCAGGCAACACTGA
CTTCTCCAGAAGTTGGACGTCTCAGTCTCAAGGAGCAGCTCTCTCATCGGCAGCATTTGTTGTCTGAGATGGAGTCACTGAAGCCGAAGG
TGCAAGCAGTGCAGCTCTGCCAGAGTGCCCTCCGGATCCCCGAGGATGTGGTTGCCAGCTTACCTCTCTGTCATGCTGCTCTGCGGCTGC
AGGAAGAGGCCAGCCGGCTGCAGCACACCGCCATCCAGCAGTGTAACATCATGCAGGCAGCTGTGGTACAATATGAACAATATGAGCAAG
AAATGAAACATCTCCAGCAACTGATAGAAGGAGCTCACAGAGAGATTGAGGATAAACCTGTTGCCACCAGTAACATACAGGAGCTGCAGG
CTCAGATTTCTCGGCATGAGGAGCTGGCGCAGAAAATTAAGGGCTACCAGGAGCAGATCGCTTCTTTGAATTCCAAGTGCAAGATGCTGA
CGATGAAAGCCAAGCACGCCACCATGCTGCTGACGGTGACCGAGGTCGAGGGGCTGGCGGAAGGGACAGAGGACCTGGATGGGGAGCTCC
TCCCCACGCCTTCGGCCCACCCCTCTGTGGTCATGATGACTGCAGGTCGCTGTCACACTTTGCTGTCACCGGTCACTGAGGAGTCTGGGG
AGGAGGGAACCAACAGTGAGATTTCCTCTCCACCTGCCTGTCGCTCCCCTTCACCTGTGGCTAATACAGATGCTTCTGTTAACCAGGACA
TTGCATATTACCAAGCCTTGTCTGCTGAGAGGTTGCAGACAGATGCTGCAAAAATTCACCCCAGCACATCCGCATCCCAGGAGTTCTATG
AACCGGGATTGGAGCCATCCGCTACTGCCAAACTGGGTGATTTGCAGCGTTCTTGGGAAACCTTAAAGAATGTGATCAGTGAGAAGCAGC
GCACACTCTATGAAGCTTTGGAACGCCAGCAGAAGTACCAGGACTCCCTCCAGTCCATCTCTACGAAGATGGAGGCCATTGAGCTGAAAC
TCAGTGAGAGCCCAGAGCCTGGCAGGAGTCCAGAAAGCCAGATGGCTGAACATCAGGCATTGATGGATGAGATTCTCATGCTCCAGGATG
AAATCAATGAGCTCCAGTCCTCTCTCGCAGAGGAGCTGGTATCCGAGTCTTGTGAGGCCGACCCTGCGGAGCAGCTGGCCTTGCAGTCCA
CGCTCACTGTCTTAGCCGAGCGAATGTCCACCATCAGGATGAAAGCCTCGGGGAAACGGCAGCTTTTGGAGGAGAAGTTGAATGATCAGC
TGGAGGAACAAAGGCAGGAACAGGCCCTGCAGAGGTATCGCTGTGAAGCCGATGAGCTGGACAGCTGGCTCTTGAGTACCAAGGCCACTC
TGGACACTGCGCTGAGTCCACCCAAGGAGCCCATGGACATGGAGGCCCAGCTTATGGACTGCCAGAATATGCTGGTGGAAATAGAGCAGA
AGGTGGTGGCTTTATCAGAACTGTCAGTCCACAATGAGAACCTGCTGCTGGAGGGCAAAGCTCACACCAAGGACGAGGCCGAGCAGCTGG
CTGGAAAGCTGAGAAGGCTCAAGGGGAGCCTGCTGGAGCTGCAGAGAGCCCTGCATGATAAGCAGCTCAACATGCAGGGAACAGCACAGG
AGAAGGAGGAGAGCGATGTTGACCTAACAGCCACGCAGAGCCCCGGCGTCCAGGAATGGCTGGCCCAAGCTCGCACCACATGGACCCAGC
AGCGGCAGAGCAGTCTCCAGCAACAAAAAGAGTTAGAACAGGAATTAGCCGAGCAGAAGAGTCTCCTTCGCTCAGTAGCCAGTCGTGGAG
AGGAGATTCTAATTCAACATTCGGCGGCAGAGACCTCTGGTGATGCTGGCGAAAAACCTGATGTGTTATCCCAGGAGTTGGGGATGGAAG
GGGAGAAATCATCCGCTGAAGACCAGATGAGAATGAAATGGGAAAGCCTACATCAAGAATTTAGTACCAAGCAGAAACTACTACAGAATG
TTCTGGAACAGGAACAAGAGCAAGTGCTTTATAGCAGGCCAAATCGACTCTTGTCTGGTGTGCCACTGTACAAAGGGGACGTGCCAACCC
AAGATAAATCTGCAGTTACATCTTTGCTGGATGGACTGAACCAAGCCTTCGAGGAGGTTTCATCCCAGAGTGGAGGGGCAAAGAGGCAGA
GTATACACTTGGAGCAGAAGTTGTATGATGGAGTCTCAGCCACCTCTACTTGGTTGGATGACGTTGAAGAACGTTTATTTGTTGCCACAG
CACTTTTACCAGAAGAAACAGAGACTTGTCTCTTCAACCAAGAGATTCTTGCCAAAGACATTAAGGAAATGTCTGAAGAAATGGATAAGA
ACAAAAACTTGTTTTCCCAAGCTTTTCCAGAGAATGGTGATAATCGAGATGTTATTGAAGATACTTTGGGTTGTCTTTTGGGCAGGTTAT
CCTTGCTAGACTCAGTAGTGAATCAACGATGTCATCAGATGAAAGAAAGACTTCAGCAAATACTAAATTTCCAGAATGATCTGAAAGTGC
TGTTTACATCACTGGCTGACAACAAATACATCATTCTGCAAAAACTGGCAAATGTGTTTGAACAGCCCGTAGCAGAACAAATAGAGGCAA
TACAACAGGCTGAAGATGGACTCAAAGAATTTGATGCAGGAATCATTGAATTAAAGAGGCGTGGTGACAAGCTACAGGTCGAGCAGCCGT
CCATGCAAGAACTCTCCAAGCTCCAGGACATGTATGATGAGCTGATGATGATCATTGGCTCCCGGAGGAGTGGTCTGAATCAGAACCTTA
CACTCAAGAGTCAGTATGAGAGGGCCCTACAAGATCTGGCTGACCTGCTAGAAACTGGTCAGGAGAAGATGGCAGGAGACCAGAAAATCA
TCGTGTCTTCCAAAGAGGAAATCCAGCAACTACTTGACAAACATAAGGAATACTTTCAGGGCCTGGAATCTCATATGATCTTGACTGAAA
CACTCTTCAGAAAGATAATCAGCTTTGCAGTCCAAAAGGAAACCCAGTTCCATACAGAGCTGATGGCTCAGGCTTCTGCTGTACTGAAAC
GGGCTCACAAGAGGGGTGTGGAGCTGGAGTACATTCTAGAGACGTGGTCCCATCTGGATGAGGACCAGCAGGAGCTCAGCAGACAGCTGG
AGGTGGTGGAAAGCAGCATCCCAAGCGTGGGTCTGGTGGAGGAGAACGAGGACAGGCTTATTGACCGCATAACACTCTACCAGCATTTAA
AATCTAGCCTTAATGAATACCAGCCCAAATTATATCAAGTATTAGATGATGGGAAACGACTTCTGATATCCATCAGCTGCTCAGATCTAG
AAAGCCAACTAAATCAACTTGGAGAGTGCTGGCTAAGTAACACCAATAAAATGTCTAAGGAACTTCACAGACTGGAAACAATATTGAAAC
ACTGGACCAGATATCAAAGTGAATCTGCAGATCTAATTCACTGGTTACAATCTGCAAAAGACCGGCTAGAATTTTGGACTCAGCAATCTG
TGACAGTCCCACAAGAGCTGGAAATGGTCCGTGATCATCTAAATGCTTTCCTGGAGTTTTCTAAAGAAGTGGATGCCCAATCTTCCCTGA
AATCATCTGTTCTGAGTACTGGAAATCAGCTCCTTCGACTAAAAAAGGTGGACACAGCCACGCTGCGCTCTGAGCTGTCGCGCATTGATA
GCCAGTGGACTGACCTGCTAACCAATATCCCAGCCGTCCAGGAGAAGCTCCACCAGCTCCAGATGGATAAACTGCCTTCCCGCCATGCCA
TTTCTGAAGTCATGAGTTGGATTTCTCTAATGGAAAATGTTATTCAGAAGGATGAAGATAATATTAAAAATTCCATAGGTTACAAGGCAA
TTCATGAATACCTTCAGAAATATAAGGGTTTTAAGATAGACATTAACTGTAAACAGCTGACAGTGGATTTTGTGAACCAGTCCGTGCTAC
AAATCAGCAGTCAGGATGTGGAAAGTAAGCGTAGTGATAAGACTGATTTTGCTGAGCAACTTGGAGCAATGAATAAAAGTTGGCAAATTC
TGCAAGGTCTAGTAACTGAGAAGATCCAGCTGTTGGAAGGCTTATTGGAATCTTGGTCAGAATATGAAAATAATGTACAATGTCTGAAAA
CATGGTTTGAAACCCAGGAAAAGAGACTAAAACAACAGCATCGAATTGGAGATCAGGCTTCTGTTCAAAATGCACTGAAAGACTGTCAGG
ATCTGGAAGATTTGATTAAAGCAAAAGAAAAAGAAGTAGAGAAAATTGAGCAGAATGGACTTGCTTTGATTCAGAACAAGAAAGAAGACG
TCTCTAGCATTGTCATGAGCACACTGCGAGAGCTCGGCCAAACCTGGGCAAATTTAGATCACATGGTTGGACAATTAAAGATACTGCTGA
AATCAGTGCTTGACCAATGGAGTAGTCACAAAGTGGCCTTTGACAAGATAAACAGTTACCTCATGGAGGCCAGATACTCTCTTTCCCGAT
TCCGTCTGCTGACTGGCTCCTTAGAAGCTGTGCAAGTTCAGGTGGACAATCTTCAGAATCTCCAAGATGATCTGGAAAAACAGGAAAGGA
GCTTACAGAAATTTGGCTCTATCACCAACCAATTATTAAAAGAGTGTCACCCACCCGTGACAGAAACTCTTACCAATACACTGAAAGAAG
TCAACATGAGATGGAATAACTTGCTGGAAGAGATTGCTGAGCAGCTACAGTCCAGCAAGGCCCTACTTCAGCTTTGGCAAAGATACAAGG
ACTACTCCAAACAGTGTGCTTCGACAGTTCAGCAGCAGGAGGATCGAACCAATGAGCTGTTGAAGGCAGCCACAAACAAGGACATTGCCG
ATGATGAGGTTGCCACATGGATTCAAGATTGCAACGACCTCCTCAAAGGACTGGGCACAGTTAAAGATTCCCTCTTTTTTCTCCATGAGC
TGGGAGAGCAACTGAAGCAACAAGTGGATGCTTCCGCAGCATCAGCTATTCAATCGGATCAACTCTCTTTGAGTCAACACTTGTGTGCCC
TGGAGCAAGCTCTCTGCAAACAGCAGACTTCATTACAGGCTGGAGTTCTTGATTATGAAACCTTTGCCAAGAGTTTAGAAGCTTTGGAGG
CCTGGATAGTGGAAGCTGAAGAAATACTACAAGGGCAGGACCCTAGCCACTCATCTGACCTCTCCACAATCCAGGAAAGGATGGAAGAAC
TTAAGGGACAGATGTTAAAATTCAGCAGCATGGCTCCAGATTTAGACCGTCTAAATGAGCTTGGATATAGGTTACCCTTGAATGATAAGG
AAATCAAAAGAATGCAGAATCTGAACCGCCATTGGTCTCTGATCTCCTCTCAGACTACAGAAAGATTCAGCAAGTTGCAGTCATTTTTGC
TACAACATCAGACTTTCTTGGAAAAATGTGAAACATGGATGGAATTCCTAGTTCAGACAGAACAAAAGTTAGCAGTAGAGATTTCAGGAA
ATTATCAGCACCTTTTGGAACAGCAGAGAGCACACGAGTTGTTTCAAGCCGAGATGTTCAGTCGTCAGCAGATTTTGCACTCAATCATTA
TTGATGGGCAACGTCTTCTAGAACAAGGTCAAGTTGATGACAGGGATGAATTCAACCTGAAATTGACACTCCTCAGTAATCAATGGCAGG
GAGTGATTCGCAGGGCCCAGCAGAGGCGGGGGATCATTGACAGCCAGATTCGCCAGTGGCAGCGCTATAGGGAGATGGCAGAAAAGCTTC
GTAAATGGTTGGTTGAAGTGTCCTACCTCCCCATGAGTGGTCTCGGAAGTGTTCCTATACCACTGCAACAAGCAAGGACCCTCTTTGATG
AAGTGCAGTTCAAAGAAAAAGTGTTTCTGCGGCAACAAGGCAGCTACATCCTGACTGTGGAGGCTGGCAAGCAACTCCTTCTCTCGGCGG
ACAGTGGCGCTGAGGCCGCCTTGCAGGCCGAACTCGCTGAAATCCAAGAGAAATGGAAATCAGCCAGCATGCGGCTGGAAGAACAGAAGA
AAAAACTAGCCTTCTTGTTGAAAGACTGGGAAAAATGTGAGAAAGGAATAGCAGATTCCCTGGAGAAACTACGAACTTTCAAAAAGAAGC
TTTCGCAGTCTCTCCCGGATCACCATGAAGAGCTCCATGCAGAACAAATGCGTTGCAAGGAATTAGAAAATGCAGTTGGGAGCTGGACAG
ATGACTTGACCCAGTTGAGCCTGCTGAAGGACACCCTCTCTGCCTATATCAGTGCTGATGATATCTCCATTCTTAATGAACGCGTAGAGC
TTCTGCAAAGGCAGTGGGAAGAACTATGCCACCAGCTCTCCTTAAGGCGGCAGCAAATAGGTGAAAGATTGAATGAATGGGCAGTCTTCA
GTGAAAAGAACAAGGAACTCTGTGAGTGGTTGACTCAAATGGAAAGCAAAGTTTCTCAGAATGGAGACATTCTCATTGAAGAAATGATAG
AGAAGCTCAAGAAGGATTATCAAGAGGAAATTGCTATTGCTCAAGAGAACAAAATACAGCTCCAACAAATGGGAGAACGACTTGCTAAAG
CCAGCCATGAAAGCAAAGCATCTGAGATTGAATACAAGCTGGGAAAGGTCAACGACCGGTGGCAGCATCTCCTGGACCTCATTGCAGCCA
GGTCAGCTTTTGCCAACTGTTTTCAAATCACATGCATGGGGGATCTTACACACACTCCTTGAGATGTTTAGCTACCGGATGCATCATATT
CAGCCTCATTACAGAGTTCAGCTCCTGAGTCATCTTCATACTTTGGCTGCAGTTGCACAAACAAACCAGAACCAGCTCCATCTTTGTGTC
GAGAGCACTGCTCTCAGGCTTATAACAGCATTAGGTAGCTCAGAGGTACAACCGCAGTTTACACGCTTCCTTAGTGATCCCAAAACAGTG
CTCTCAGCAGAATCTGAAGAACTGAACCGAGCCTTGATATTGACCTTGGCTAGAGCAACTCATGTAACAGATTTTTTTACAGGCTCTGAT
TCAATTCAGGGAACTTGGTGTAAAGACATACTTCAGACCATCATGAGTTTCACTCCTCATAATTGGGCTTCACACACCCTGAGCTGTTTT
CCAGGCCCACTACAGGCATTCTTCAAACAAAATAATGTGCCTCAGGAAAGCCGTTTTAATCTGAAAAAAAATGTGGAGGAGGAGTATAGG
AAGTGGAAGTCAATGAGCAACGAAAACGACATTATTACCCACTTCTCTATGCAGGGCTCCCCTCCTCTCTTTCTTTGTCTTCTCTGGAAA
ATGCTCTTGGAAACAGATCATATTAATCAGATTGGCTATAGAGTATTAGAGAGAATTGGAGCCAGGGCCTTGGTAGCCCATGTGAGGACA
TTTGCAGATTTCCTGGTATATGAGTTTTCTACATCAGCAGGGGGTCAGCAACTCAATAAATGCATTGAAATTCTTAATGACATGGTATGG
AAGTATAACATTGTTACACTGGACAGATTAATTCTCTGCCTGGCCATGCGTAGTCACGAAGGAAATGAAGCCCAGGTTTGTTATTTCATA
ATTCAGTTGCTGTTACTCAAACCAAACGATTTTAGAAATCGAGTAAGTGACTTTGTGAAGGAAAATTCCCCAGAGCACTGGTTACAGAAT
GACTGGCACACCAAGCACATGAATTATCACAAGAAATATCCAGAGAAGTTGTATTTTGAGGGCCTCGCGGAACAGGTGGATCCTCCTGTA
CAGATCCAGTCTCCCTATCTGCCCATCTATTTTGGGAATGTGTGTCTTCGATTCCTTCCAGTATTTGATATAGTAATCCACAGATTTTTA
GAGTTGCTTCCGGTATCCAAATCACTGGAGACTCTACTGGATCATCTAGGAGGCTTATATAAATTTCATGATCGTCCAGTGACTTATCTG
TATAACACTCTGCACTATTATGAAATGCACCTGAGAGACCGCGCATTTCTCAAACGAAAACTCGTCCATGCGATCATTGGCTCTCTGAAG
GATAATCGACCGCAGGGCTGGTGTCTAAGTGACACTTACCTGAAATGCGCTATGAATGCACGAGAGGAAAATCCTTGGGTTCCAGATGAC
ACCTACTATTGCAGATTGATTGGCAGACTAGTCGATACGATGGCTGGCAAATCTCCTGGTCCCTTTCCAAACTGTGACTGGAGATTCAAT
GAGTTTCCCAACCCAGCTGCCCATGCTCTCCATGTTACTTGTGTGGAGCTCATGGCCTTGGCAGTTTCAGGCAAAGAAGTTGGGAATGCC
CTTCTAAATGTTGTCCTAAAAAGTCAGCCTTTAGTGCCAAGAGAGAACATTACAGCATGGATGAATGCAATTGGTTTGATCATCACTGCC
CTACCAGAGCCATATTGGATTGTTCTTCATGATCGAATTGTGAGTGTCATCAGCAGCCCCAGCTTGACGTCTGAAACAGAGTGGGTTGGC
TATCCATTCCGCCTCTTTGATTTCACTGCCTGTCATCAGTCCTACTCTGAGATGAGTTGTAGCTATACGTTAGCTCTTGCACATGCTGTG
TGGCACCATTCTAGCATCGGACAACTTTCTCTCATTCCAAAGTTTCTTACTGAAGTACTTCTTCCTATAGTGAAGACCGAATTCCAGTTG
CTTTATGTATACCATCTTGTTGGACCATTTTTACAAAGATTTCAGCAAGAGAGAACTCGTTGTATGATAGAGATTGGTGTGGCGTTTTAT
GACATGCTGCTGAATGTTGACCAGTGTAGCACCCATTTAAATTACATGGATCCCATCTGTGACTTCCTCTATCACATGAAGTATATGTTT
ACTGGTGACAGCGTGAAAGAGCAAGTAGAGAAGATTATCTGTAACTTAAAACCAGCTTTAAAACTTCGTCTTCGATTCATCACACACATT
AGCAAGATGGAGCCAGCTGCAGTGCCTCCACAAGCCATGAACAGTGGGTCTCCAGCACCTCAGTCTAATCAGGTGCCCGTGTCTTTACCA
GTAACTCAGTGAAGCCAGACTGTACTGTGGAGAAAGTAGAAATATATCCGTCTTTGAGAGTGGACTCAAACCTTTTAAATCTGAATGCGA
TCACACTGTAGTGATATAGTAGAAGCAGTGATGATATTCAGATTGTTTTATTTTGATTCAAATGATGAATCTGTTGACACCTTATAACTC
CCATCTCCCTATCTATATTTTTGTCTCTAAGAGATCAAGTAAGATACATGTTGTTCATATTCATAACAACTTATTAGAGCTATGTAGGAA
CATAGAGGTATCTGTGATCAAATGACTTGTCATTGGCACTTTCAGTCTTTCCTATTCTAGCCGTTGTTTTTGTTTGTATTTTTTATTATT
AATGACATATTTAGTCTTCAGATATATTATTTTAAAGGCACCACACATGTAAAACAGTTATTACAAATATTTTATACATAAATCTCTTGG
TAGATTTTCAGAATAATAGAGATTTATATCAAGAAAAGGAATCTAGATTTTGTTGCATTGTAGGAGCAAACAAGGCTTCATATTCTTTTT
AAAATGACTTGAAATTTTATTATAAATTTCCATAGTTTCTATCAAGGTCAACTGGCAGTTTTATTACCTTTGCTATGGACTTGAACTTAC
TGTATAAAATTAGTTGGAAGCCATGTAAGAAAATAACATCTGAAAATTCTTGAACTTAAAATCATGCTTAAATGGTTGATTCTCCAATTT
CTTTTTTTAAAAATAAGTTAATTGCTTTTGCAGGTTGACACTCTCACCTGACAGATGATGTAATTCTTCAATTTTTATAATCTTAAAATT
TTTAAATTTTATATTTGTAAATACAGTACACATTTTATTTCTTGGATTTTGAGAGACATTGTTAATTTTGGGGGAATTGGCATTGCGAAA

>88409_88409_2_SYNE1-MED23_SYNE1_chr6_152497529_ENST00000423061_MED23_chr6_131924344_ENST00000368068_length(amino acids)=7824AA_BP=7804
MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGRRMKRIHAVA
NIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVT
TKIQGNAKKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPEDVDV
DKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKH
FRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQ
RKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRR
ESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVA
SLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEY
TDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECY
SPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFD
QTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACD
ELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHL
CEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV
KRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSK
EVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWE
RFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDT
LEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIK
AKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFS
ASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQ
NEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSE
ISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGI
LRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEA
DALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRL
EVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL
SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESE
VKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQN
ETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFL
GAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDC
ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLT
SHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALR
SSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEA
EDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDS
SATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVA
QLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQ
ASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGI
QAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRL
KEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKL
EALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLN
ESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKA
FEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQF
NNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQ
SLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHME
QLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLE
LVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSL
EHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQK
LVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEI
NHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQK
MIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAIC
SELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREH
ICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDF
DKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKD
KFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDK
MLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLED
LAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQ
EEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGN
GLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKARE
EVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQD
QEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEP
PLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQ
KEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDG
CNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQ
LREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQA
QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYE
QYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDL
DGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS
QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEIL
MLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLS
TKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQ
GTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQE
LGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGG
AKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCL
LGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQ
VEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHM
ILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITL
YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFW
TQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLP
SRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNK
SWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQN
KKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLE
KQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATN
KDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSL
EALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKL
QSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLS
NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQL
LLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAV
GSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILI

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>88409_88409_3_SYNE1-MED23_SYNE1_chr6_152497529_ENST00000423061_MED23_chr6_131924344_ENST00000403834_length(transcript)=27148nt_BP=23851nt
CGGCCGCCGGCCGCAGCGGGCTGAGATTGTTGTCCTCTGTCACCAGGGCGGCTGGGCTCCCGCAGTCCTGCAGACCGCGCCCGATCCCGG
CGACAGGGCGGGCGGACAGCCGCGCATCCCCGGGGTCCCGCCGAGCCTGGGCGCAGAGAGCCGGGAGGAAGCGTTCGCTCGCTTCGCCTT
GCTGCTGGGAAACTGAACGAGGCCGAGAGAGAAGGTTCTTGAGTTCATGTAAGAGGACAGTCTTAAAACGGAAGAAGAAAAAGAAGCAGT
TCAGTCTTTGGGAGAGCTGCCTCCTTGTTGAGTGCTGCAAAGGCCTGGAATTCATTTATGACAGAATAGATCTAGAAAAGTCCAAGCATG
TTTTCTAGAGTGGTGTAGCCCTGTGCTGCCTCCAGTGAAGAGTCTCTTGGTGTTGGCTTCGTGCTTCCGGAGGGACCATGGCAACCTCCA
GAGGGGCCTCCCGGTGTCCTCGGGATATCGCCAATGTGATGCAGAGGCTGCAAGATGAGCAAGAGATAGTACAAAAACGAACTTTCACAA
AATGGATCAACTCTCATCTGGCCAAGCGGAAACCTCCAATGGTGGTGGACGATCTTTTTGAAGACATGAAAGATGGTGTTAAACTGCTTG
CCCTTCTGGAGGTCCTGTCTGGGCAGAAACTGCCTTGTGAACAAGGACGCCGGATGAAGCGAATCCATGCTGTGGCTAACATTGGCACGG
CACTCAAGTTCCTCGAAGGAAGAAAGTCCATGCACAGAGGATCACCGATTAAATTAGTCAACATTAACTCCACCGATATAGCTGATGGCC
GACCCTCAATAGTTCTTGGATTGATGTGGACCATTATTCTATATTTCCAGATTGAAGAGTTGACCAGCAACCTGCCCCAGCTCCAGTCTT
TGTCCAGCAGCGCATCCTCCGTGGACAGCATAGTTAGCTCTGAGACTCCCAGCCCACCAAGTAAACGGAAGGTGACCACCAAGATCCAAG
GAAATGCTAAGAAGGCTTTATTAAAGTGGGTTCAGTACACAGCTGGCAAGCAGACTGGAATAGAAGTAAAAGATTTTGGGAAGAGTTGGA
GAAGCGGGGTTGCCTTTCATTCAGTTATTCATGCCATTCGACCGGAATTGGTGGACTTGGAGACAGTGAAAGGCAGATCCAACCGAGAAA
ATTTGGAGGATGCTTTCACTATCGCCGAAACAGAACTGGGGATCCCAAGACTGCTAGATCCTGAAGACGTTGATGTGGATAAACCAGATG
AGAAATCTATTATGACCTATGTAGCCCAGTTTCTGAAACATTATCCTGACATCCACAATGCAAGCACTGATGGGCAAGAGGATGATGAAA
TACTTCCAGGTTTCCCATCTTTTGCAAATTCTGTACAAAATTTTAAGAGAGAAGACAGAGTAATTTTTAAGGAAATGAAAGTTTGGATAG
AACAATTTGAGAGAGATTTGACAAGAGCACAGATGGTGGAATCAAATTTACAGGATAAATATCAGTCATTTAAGCACTTCAGAGTTCAAT
ATGAAATGAAGAGGAAACAGATTGAACATTTAATACAACCATTACACAGAGACGGTAAATTGTCACTTGACCAAGCATTGGTAAAACAAT
CTTGGGATAGAGTGACCTCCAGGCTCTTTGACTGGCATATACAGCTTGATAAATCTCTTCCTGCACCTCTGGGCACCATAGGTGCCTGGC
TGTACAGAGCGGAGGTGGCCCTGAGAGAGGAAATAACCGTTCAACAGGTCCACGAGGAAACAGCAAACACGATACAACGGAAACTTGAGC
AACATAAGGATCTGCTTCAAAACACGGATGCCCACAAAAGAGCATTCCATGAAATCTACCGGACCAGGTCTGTTAACGGGATTCCAGTGC
CACCTGATCAATTAGAGGACATGGCCGAGAGGTTTCATTTTGTTTCCTCCACATCAGAGCTACACCTAATGAAAATGGAATTTTTAGAAT
TAAAGTACCGTCTGCTCTCACTGCTGGTTCTTGCAGAGTCAAAGCTGAAGTCTTGGATCATTAAGTACGGGAGGAGAGAGTCAGTGGAGC
AGCTTCTACAAAACTACGTGTCTTTTATAGAAAATAGCAAGTTCTTTGAACAATATGAGGTGACATACCAGATCTTGAAACAGACAGCTG
AGATGTATGTCAAAGCAGATGGTTCAGTGGAAGAAGCTGAGAATGTGATGAAATTCATGAATGAAACCACCGCTCAGTGGAGGAATCTCT
CAGTAGAAGTGAGGAGTGTGAGGAGCATGCTGGAAGAAGTGATCTCTAACTGGGATCGCTATGGCAATACAGTGGCTAGTCTGCAAGCCT
GGCTAGAGGATGCTGAAAAAATGCTCAATCAATCAGAAAATGCCAAAAAGGATTTTTTTCGAAATTTACCTCATTGGATTCAGCAGCATA
CTGCCATGAACGATGCTGGCAATTTTCTAATTGAAACCTGTGATGAGATGGTTTCCCGTGACCTGAAGCAGCAATTACTGTTGCTAAATG
GGCGGTGGAGGGAGTTGTTTATGGAAGTCAAGCAATATGCTCAAGCTGATGAGATGGACAGAATGAAGAAGGAATACACAGACTGTGTTG
TTACCCTGTCTGCTTTTGCAACGGAAGCCCATAAGAAACTTTCTGAACCCTTAGAAGTCTCTTTTATGAATGTCAAGCTATTAATTCAAG
ACTTGGAGGATATTGAGCAGAGGGTGCCTGTGATGGATGCCCAATACAAGATAATTACAAAGACAGCACACCTCATTACCAAAGAAAGCC
CCCAAGAAGAAGGAAAAGAAATGTTTGCGACCATGTCAAAGCTCAAAGAGCAGCTAACCAAGGTCAAAGAATGTTACTCCCCACTCCTTT
ATGAGTCTCAGCAGCTGTTGATTCCGTTGGAGGAATTAGAAAAGCAGATGACGTCCTTTTATGACTCACTTGGGAAAATCAATGAAATTA
TCACAGTTCTTGAGCGTGAGGCACAATCGAGTGCCCTTTTTAAACAAAAACATCAGGAACTGTTAGCTTGTCAAGAAAACTGTAAGAAAA
CCTTGACACTTATTGAGAAAGGCAGTCAAAGTGTTCAAAAGTTTGTGACCTTGAGCAACGTGTTAAAGCATTTTGATCAGACGAGGCTAC
AAAGACAGATTGCAGATATTCATGTTGCTTTTCAGAGTATGGTAAAGAAAACTGGAGATTGGAAGAAGCATGTGGAAACCAACAGTCGCT
TGATGAAGAAGTTTGAGGAGTCTCGAGCAGAGTTGGAGAAGGTACTGCGGATTGCTCAGGAGGGCCTGGAGGAAAAGGGGGATCCAGAGG
AGCTCCTGCGGAGACACACTGAGTTTTTCAGTCAGCTGGATCAGAGGGTGCTCAATGCTTTCCTGAAAGCTTGTGATGAACTCACCGACA
TCCTTCCAGAGCAGGAGCAGCAGGGGCTGCAGGAAGCTGTTCGAAAGCTCCACAAACAATGGAAGGATCTTCAAGGAGAAGCCCCTTATC
ATTTGCTTCATCTGAAGATTGATGTGGAGAAGAATAGGTTCTTAGCCTCTGTAGAAGAATGCAGAACTGAGCTGGATCGAGAGACCAAGC
TGATGCCCCAGGAAGGCAGTGAAAAGATAATTAAAGAGCACAGGGTTTTCTTCAGTGACAAAGGTCCTCATCATCTCTGTGAGAAAAGGT
TACAGCTCATCGAGGAACTCTGTGTGAAACTCCCAGTGCGGGACCCAGTAAGGGACACACCTGGAACCTGTCACGTGACTCTCAAAGAGC
TCAGAGCTGCCATTGACAGCACCTACAGGAAGCTCATGGAAGACCCAGACAAGTGGAAGGACTACACTAGCAGATTCTCTGAGTTCTCAT
CTTGGATATCTACAAATGAGACACAATTAAAGGGGATCAAGGGTGAGGCCATCGATACTGCCAACCACGGAGAGGTTAAACGTGCCGTTG
AAGAGATCAGAAATGGTGTTACCAAAAGGGGTGAGACCCTCAGCTGGCTGAAATCCAGGCTGAAAGTTTTGACAGAAGTTTCTTCTGAGA
ATGAAGCCCAAAAGCAGGGAGATGAGCTGGCAAAATTATCCAGCTCTTTCAAGGCTCTTGTGACGCTGCTGTCAGAGGTTGAAAAGATGC
TAAGCAATTTTGGGGACTGTGTCCAGTACAAAGAAATAGTCAAAAATTCTCTCGAAGAATTAATTTCTGGCTCTAAAGAAGTCCAGGAAC
AAGCTGAGAAGATCTTGGATACTGAAAATCTGTTTGAAGCACAGCAGTTACTTCTTCATCACCAGCAAAAGACAAAGCGGATCTCAGCAA
AGAAGAGAGATGTGCAGCAGCAGATCGCGCAGGCGCAGCAGGGAGAAGGGGGGCTGCCTGACCGAGGCCACGAGGAGCTGCGGAAGCTGG
AGAGCACACTGGATGGCCTGGAGCGCAGCCGGGAGAGGCAGGAACGCCGCATCCAGGTCACATTAAGAAAATGGGAGCGATTTGAAACAA
ACAAAGAAACAGTAGTAAGATACCTTTTTCAAACAGGTTCCAGTCATGAACGCTTCTTGAGTTTTAGCAGTTTGGAAAGTTTATCTTCAG
AACTGGAACAAACAAAGGAGTTTTCTAAACGGACAGAAAGTATTGCAGTCCAGGCTGAGAACCTTGTAAAGGAAGCTTCAGAGATACCGC
TTGGGCCCCAAAATAAGCAGCTGCTTCAACAGCAGGCCAAGTCAATCAAAGAACAAGTCAAAAAATTAGAAGACACGCTTGAAGAAGATA
TTAAAACCATGGAAATGGTGAAAACCAAGTGGGATCATTTTGGCAGTAATTTTGAGACTCTGTCCGTCTGGATAACTGAGAAAGAAAAAG
AACTCAATGCCTTGGAAACTTCGTCATCTGCCATGGACATGCAAATCAGCCAAATTAAGGTCACAATTCAGGAAATAGAAAGTAAGCTCA
GCAGCATTGTAGGATTAGAAGAAGAAGCCCAGTCTTTTGCTCAGTTTGTTACCACTGGAGAATCTGCTCGAATTAAAGCCAAGTTGACAC
AAATAAGAAGATACGGGGAAGAGCTTCGAGAGCATGCACAGTGTCTGGAAGGAACAATCCTGGGACATTTATCTCAGCAGCAAAAGTTTG
AAGAGAACCTTAGAAAGATCCAGCAATCTGTGTCTGAATTTGAAGATAAACTTGCTGTTCCAATTAAAATATGTTCTTCAGCTACAGAAA
CATACAAAGTTCTTCAAGAACATATGGATCTCTGCCAGGCCCTGGAGTCACTGAGCAGCGCGATCACTGCCTTCTCAGCCAGTGCCAGGA
AGGTTGTGAACAGAGATTCCTGTGTTCAGGAGGCTGCGGCTCTACAGCAGCAATACGAGGACATCCTAAGGAGGGCGAAGGAGAGACAGA
CGGCGCTGGAGAATCTGCTGGCCCACTGGCAGAGGCTAGAGAAAGAACTATCATCCTTTTTGACCTGGTTAGAGCGGGGTGAAGCTAAAG
CCAGTTCCCCAGAAATGGACATTTCTGCAGACAGAGTCAAAGTGGAAGGTGAACTTCAGTTAATACAGGCACTGCAAAATGAAGTTGTAT
CCCAGGCCTCATTCTATAGCAAACTTTTGCAATTGAAGGAATCATTGTTCTCAGTAGCCTCCAAAGATGATGTGAAAATGATGAAACTAC
ATTTGGAGCAGTTGGATGAGAGATGGAGAGATTTACCACAGATCATTAACAAAAGGATTAATTTTCTTCAGTCTGTGGTTGCTGAACACC
AGCAATTTGATGAGCTGCTGCTTTCCTTTTCTGTCTGGATTAAACTGTTTCTCAGTGAATTACAAACTACCTCTGAGATTAGCATAATGG
ACCATCAAGTAGCCCTTACTCGGCATAAGGACCACGCAGCAGAAGTAGAGAGCAAAAAGGGCGAATTGCAGAGTCTGCAGGGTCACTTAG
CAAAGTTGGGTTCTCTGGGCCGTGCTGAGGACCTCCACCTCCTGCAGGGAAAGGCTGAGGACTGCTTCCAGCTGTTTGAGGAGGCCAGCC
AGGTTGTGGAGAGGCGGCAGCTTGCCCTGTCCCATTTGGCAGAATTCCTCCAGAGCCATGCCTCTCTGTCCGGCATTCTCCGCCAGCTGA
GGCAAACAGTGGAAGCAACCAACAGTATGAATAAGAACGAGTCTGATTTGATAGAAAAGGACCTCAATGATGCTCTTCAAAATGCTAAAG
CATTAGAATCTGCTGCCGTCAGTCTGGATGGCATTCTTTCCAAAGCCCAATACCATCTGAAAATCGGGAGCTCTGAGCAAAGGACTTCCT
GCAGAGCCACGGCTGATCAGCTCTGTGGAGAGGTAGAGAGGATCCAGAACCTTCTGGGAACCAAGCAGAGTGAGGCAGATGCTCTGGCAG
TGTTGAAAAAAGCATTCCAAGACCAGAAAGAGGAGCTTCTGAAAAGCATTGAGGACATTGAAGAAAGGACTGACAAAGAGCGATTGAAAG
AACCTACCCGCCAAGCTCTTCAGCAGAGGTTAAGAGTGTTTAATCAGCTAGAAGATGAATTGAATTCTCACGAGCATGAACTATGTTGGT
TGAAAGACAAAGCCAAGCAAATTGCCCAGAAAGATGTAGCTTTTGCACCTGAAGTTGACAGGGAGATAAACCGCTTAGAGGTCACCTGGG
ATGATACCAAAAGACTAATTCATGAAAATCAGGGTCAGTGCTGTGGACTTATTGACTTAATGAGAGAATATCAGAACCTGAAATCAGCTG
TATCTAAAGTCTTAGAAAATGCCAGCAGTGTGATTGTAACCAGAACTACCATAAAAGATCAGGAGGATCTTAAATGGGCTTTTTCCAAGC
ATGAAACTGCCAAGAACAAAATGAATTACAAACAGAAAGACTTGGATAACTTTACCAGCAAAGGAAAACACTTGTTATCTGAGCTGAAGA
AAATTCACAGTAGTGATTTCAGCTTGGTGAAAACAGACATGGAGAGCACCGTGGACAAATGGCTGGATGTATCAGAGAAACTTGAAGAAA
ACATGGATAGGCTGAGAGTAAGCCTGTCCATTTGGGATGATGTACTGTCAACTAGAGATGAGATTGAGGGATGGTCAAACAACTGCGTTC
CACAGATGGCAGAAAACATCAGCAACCTGGATAACCACCTCAGAGCTGAAGAACTGCTTAAAGAATTTGAGTCTGAAGTTAAAAACAAAG
CATTGAGATTGGAAGAACTGCATTCCAAAGTTAATGATCTGAAAGAATTAACTAAAAATCTAGAAACACCGCCAGACCTTCAGTTTATAG
AAGCAGACTTAATGCAGAAACTGGAGCATGCCAAAGAAATAACTGAAGTAGCAAAAGGAACCCTGAAGGATTTCACGGCTCAAAGTACAC
AAGTGGAGAAGTTTATTAATGACATAACAACATGGTTCACAAAAGTGGAAGAATCGTTGATGAACTGTGCCCAAAATGAGACTTGTGAAG
CATTGAAAAAAGTCAAGGATATACAAAAAGAACTTCAAAGTCAACAAAGCAACATCAGCTCTACCCAAGAAAATCTCAATAGCTTGTGCC
GCAAGTACCACTCAGCTGAGTTGGAGAGCCTGGGCCGTGCAATGACTGGTCTGATAAAGAAACATGAAGCCGTGAGCCAGTTGTGCTCCA
AAACCCAGGCCAGCCTGCAGGAATCTCTGGAAAAACACTTCAGTGAGTCTATGCAGGAATTCCAAGAATGGTTTTTGGGAGCAAAGGCAG
CAGCAAAAGAATCATCAGATCGCACCGGTGACAGCAAAGTTCTAGAAGCAAAGCTCCATGATCTTCAGAACATTTTGGACTCAGTCAGTG
ATGGGCAGAGCAAACTTGATGCAGTGACTCAAGAAGGACAAACTTTGTATGCACATTTGTCTAAACAAATTGTCAGTAGCATTCAAGAAC
AAATCACAAAGGCCAATGAAGAGTTTCAAGCATTTCTGAAACAATGCCTTAAAGATAAGCAGGCTCTTCAAGACTGTGCTTCAGAACTTG
GAAGCTTTGAAGATCAGCACAGAAAACTGAACTTATGGATCCATGAAATGGAAGAAAGGTTCAATACGGAAAACTTGGGAGAGAGTAAAC
AGCACATTCCTGAGAAGAAAAATGAAGTTCATAAAGTTGAAATGTTTTTGGGAGAACTGCTGGCTGCAAGAGAGTCTCTTGATAAGCTTT
CCCAGAGAGGGCAGCTTCTGAGTGAAGAAGGCCACGGTGCTGGGCAGGAGGGCCGCCTGTGTTCCCAGCTCCTCACAAGCCACCAGAACC
TACTTAGAATGACCAAAGAGAAACTCCGGAGCTGCCAGGTGGCCCTTCAGGAGCACGAAGCCCTGGAGGAAGCACTGCAAAGCATGTGGT
TCTGGGTGAAGGCCATTCAGGACAGACTGGCCTGTGCAGAGAGCACTCTTGGGAGCAAAGACACCCTGGAGAAACGGCTGTCACAAATAC
AGGATATTCTCCTGATGAAAGGTGAAGGGGAAGTTAAGTTGAATATGGCCATTGGCAAGGGGGAACAGGCCTTGAGAAGTAGCAACAAAG
AAGGTCAGAGGGTGATTCAGACTCAGTTAGAGACCCTTAAAGAAGTGTGGGCTGACATCATGAGCTCCTCCGTCCACGCTCAAAGCACTT
TAGAGTCTGTGATTAGCCAATGGAATGACTATGTAGAGAGGAAAAACCAGTTGGAGCAGTGGATGGAATCAGTGGATCAAAAAATAGAAC
ATCCCTTACAACCACAGCCAGGTCTGAAAGAGAAGTTCGTCCTGCTTGACCACCTCCAGTCCATCCTGTCTGAGGCAGAAGATCACACGA
GAGCCCTTCACCGTCTAATTGCGAAGTCCAGGGAGCTCTACGAAAAGACAGAGGATGAGTCTTTCAAGGACACAGCTCAAGAGGAGCTGA
AAACACAGTTTAATGATATAATGACTGTTGCCAAGGAAAAAATGAGGAAAGTGGAAGAGATTGTGAAAGATCATCTAATGTATTTAGATG
CGGTCCACGAGTTCACAGATTGGCTCCATTCAGCAAAGGAAGAACTTCACCGGTGGTCAGATATGTCTGGAGATTCATCAGCCACCCAGA
AAAAGTTATCAAAAATTAAGGAGCTGATAGATTCCAGAGAGATTGGTGCAAGCCGTCTCAGCAGAGTGGAGTCGCTGGCTCCCGAAGTGA
AACAGAACACAACTGCCAGTGGGTGTGAGCTCATGCACACGGAGATGCAGGCCCTGCGTGCCGACTGGAAGCAGTGGGAAGACAGTGTAT
TCCAAACGCAGAGCTGTTTGGAGAACCTGGTCAGCCAGATGGCCCTTTCGGAGCAGGAATTCTCAGGCCAAGTGGCTCAACTGGAGCAGG
CCCTGGAACAGTTCAGTGCCCTTCTGAAAACCTGGGCTCAGCAGTTAACCCTCCTGGAAGGCAAGAACACGGATGAGGAGATAGTGGAAT
GCTGGCACAAAGGACAAGAGATACTGGATGCTTTGCAAAAAGCAGAGCCTAGAACAGAGGATCTCAAGTCTCAGCTGAATGAACTTTGTC
GATTTTCCAGAGACCTGAGTACCTACAGTGGAAAAGTTTCTGGCTTGATTAAAGAGTATAATTGTCTTTGTTTGCAAGCATCCAAGGGCT
GCCAGAATAAAGAACAGATTTTACAGCAAAGATTTCGAAAGGCCTTCAGGGATTTCCAGCAGTGGTTGGTTAATGCAAAAATCACTACCG
CCAAGTGTTTTGATATACCTCAAAATATAAGTGAAGTTTCAACTAGTCTTCAGAAAATACAGGAGTTTTTGTCAGAAAGTGAAAATGGAC
AGCACAAGCTAAACATGATGCTGTCTAAAGGGGAACTTCTGAGTACCCTGCTGACCAAAGAGAAAGCGAAAGGGATCCAGGCCAAAGTTA
CAGCTGCAAAAGAAGATTGGAAAAATTTTCATTCAAATCTCCACCAAAAAGAATCTGCTCTAGAGAATCTAAAGATCCAAATGAAGGACT
TTGAAGTAAGTGCTGAGCCTATCCAGGACTGGCTGAGTAAAACTGAGAAGATGGTCCATGAAAGCAGCAATCGCCTCTATGATCTGCCAG
CAAAGAGGAGGGAGCAGCAGAAGCTCCAGTCTGTCCTTGAGGAAATACACTGCTACGAGCCTCAGCTCAACAGGCTGAAAGAGAAAGCTC
AGCAGCTGTGGGAAGGACAAGCTGCCAGCAAGAGCTTTAGGCACAGAGTGTCGCAGCTGTCTTCTCAGTATCTAGCGCTAAGCAATTTAA
CAAAGGAGAAAGTGTCAAGACTGGATAGAATCGTTGCAGAACACAATCAGTTCTCTCTTGGGATTAAAGAATTACAAGACTGGATGACGG
ATGCGATTCACATGCTGGATTCATACTGCCACCCGACATCCGACAAAAGTGTGCTGGACAGCAGGACGCTCAAGCTCGAGGCTCTATTAT
CAGTCAAACAGGAAAAAGAGATTCAGATGAAAATGATAGTGACCAGGGGAGAATCTGTCCTTCAGAATACTTCTCCAGAAGGCATTCCCA
CTATTCAGCAGCAGCTGCAGAGTGTGAAGGATATGTGGGCATCCCTTTTGTCTGCAGGGATTCGTTGTAAAAGCCAACTCGAAGGAGCTC
TCTCCAAGTGGACAAGTTATCAGGATGGCGTTCGACAGTTCTCCGGTTGGATGGATAGTATGGAAGCCAACCTGAATGAATCAGAAAGGC
AGCATGCGGAGCTGCGGGATAAAACAACGATGCTCGGAAAAGCCAAGTTATTAAATGAAGAAGTGCTGAGTTACAGCAGCTTGCTGGAGA
CCATCGAAGTCAAAGGGGCTGGCATGACAGAACACTATGTCACCCAGCTAGAACTCCAGGATCTACAGGAACGATACAGAGCCATCCAAG
AGAGGGCCAAGGAAGCCGTAACCAAGTCTGAAAAACTTGTCCGCCTGCACCAAGAGTATCAGAGAGACCTAAAGGCATTTGAAGTTTGGT
TGGGGCAAGAACAAGAAAAGCTCGACCAGTATTCAGTTCTTGAAGGTGATGCCCACACTCATGAGACAACATTGCGTGATCTTCAGGAGC
TACAGGTACACTGTGCAGAGGGGCAGGCCCTGTTGAACTCAGTGCTGCACACCAGAGAGGATGTGATCCCATCAGGTATCCCACAGGCAG
AGGACCGGGCTTTAGAGTCTCTCCGGCAAGACTGGCAGGCTTACCAGCACAGGCTGTCCGAGACTCGAACTCAGTTCAATAACGTGGTGA
ACAAATTGAGGCTAATGGAGCAAAAGTTTCAGCAAGTAGATGAATGGCTCAAAACAGCAGAGGAGAAAAAGTGGCACGAAGAAGTGACTG
CATACAGAGATGAAGTTGAGGAAGTGGGAGCTAGAGCTCAGGAGATACTGGACGAGAGCCACGTGAACAGCAGAATGGGTTGCCAGGCCA
CCCAGCTGACTTCCAGATACCAGGCCCTGCTTCTCCAAGTGCTGGAACAAATAAAATTCCTGGAGGAGGAGATTCAGAGTTTGGAGGAAT
CAGAATCATCCCTCAGTTCCTATTCTGATTGGTATGGCTCTACTCATAAAAACTTCAAGAATGTGGCTACCAAGATTGACAAAGTAGATA
CAGTAATGATGGGGAAGAAATTGAAGACGTTGGAGGTTTTGCTCAAAGACATGGAGAAAGGTCACAGTTTGCTGAAATCAGCCCGGGAGA
AAGGAGAGAGGGCTGTTAAATACTTGGAGGAAGGCGAGGCAGAGAGGTTAAGAAAGGAGATTCATGATCACATGGAGCAGTTGAAGGAAC
TGACCAGCACTGTCCGGAAAGAACACATGACGCTGGAAAAAGGTCTTCATTTAGCAAAGGAATTCTCAGATAAATGCAAAGCACTGACAC
AGTGGATAGCAGAATACCAGGAAATTCTACATGTTCCTGAAGAACCCAAAATGGAATTATATGAGAAAAAAGCTCAGTTATCTAAATACA
AGTCACTTCAACAAACGGTGCTGTCCCATGAACCATCAGTAAAGTCAGTGAGAGAGAAGGGTGAAGCTCTTTTGGAACTGGTGCAGGACG
TCACTTTAAAGGACAAAATAGATCAACTTCAAAGTGATTACCAGGACCTGTGCAGCATAGGAAAGGCAATGATGGAAGAAATTGCTGGTT
TTGAAGACCGTTTGAACAATCTTCAAATGAAAGGTGATACTTTGATTGGCCAATGTGCAGACCACCTGCAAGCGAAACTTAAACAAAACG
TGCATGCTCATCTGCAGGGCACAAAGGACAGCTACTCAGCGATCTGCAGCACAGCTCAGAGGATGTACCAGAGTTTGGAACACGAACTTC
AGAAGCACGTCAGCCGACAAGACACCCTGCAGCAGTGCCAGGCCTGGCTTTCTGCAGTCCAGCCGGATTTAGAGCCAAGTCCTCAACCAC
CTCTTAGTAGGGCAGAAGCCATTAAGCAGGTCAAACACTTCAGAGCTTTGCAAGAGCAGGCAAGGACCTACCTAGATCTCCTTTGCTCCA
TGTGTGACCTGTCAAATGCTTCGGTGAAAACCACAGCAAAAGACATTCAACAAACAGAGCAAACGATTGAACAAAAGCTTGTCCAGGCCC
AGAACTTAACTCAGGGCTGGGAAGAGATCAAGCACCTGAAGTCTGAGCTCTGGATTTACCTGCAAGATGCTGATCAGCAACTGCAGAACA
TGAAGAGGAGGCACTCTGAGCTGGAGCTGAACATTGCACAGAACATGGTTTCACAAGTTAAGGATTTTGTTAAGAAACTACAGAGCAAAC
AGGCATCCGTGAACACCATAATAGAAAAGGTGAATAAGTTAACAAAGAAGGAGGAATCGCCTGAACACAAGGAAATAAATCATTTAAATG
ATCAGTGGCTCGATTTGTGCCGTCAGTCTAACAACCTGTGCTTGCAAAGGGAAGAGGATCTTCAGAGAACAAGAGATTACCATGACTGTA
TGAATGTTGTTGAAGTGTTCCTAGAAAAATTTACTACAGAATGGGATAACTTGGCCAGATCTGATGCAGAGAGTACAGCTGTCCACCTGG
AAGCTTTGAAAAAGTTAGCATTGGCATTGCAGGAGAGAAAGTATGCTATTGAAGATCTGAAAGATCAAAAGCAGAAAATGATAGAGCATC
TGAATTTAGATGACAAGGAGTTAGTCAAAGAACAGACGAGTCATTTAGAGCAACGTTGGTTTCAGCTTGAGGACCTCATTAAAAGGAAAA
TCCAAGTGTCAGTCACCAACTTGGAGGAGTTAAATGTGGTGCAGTCCAGATTTCAGGAGCTAATGGAGTGGGCAGAAGAGCAACAACCCA
ACATCGCCGAGGCCCTTAAGCAGAGCCCTCCTCCAGATATGGCTCAGAACCTTCTCATGGATCACCTGGCCATCTGCAGTGAACTGGAGG
CCAAGCAGATGCTCCTGAAATCGCTTATAAAGGACGCAGACAGGGTCATGGCAGATCTTGGTCTCAATGAGCGACAGGTCATCCAGAAGG
CTCTCTCTGATGCACAAAGCCACGTGAATTGTCTCAGTGACTTAGTGGGCCAGCGAAGAAAGTACTTAAACAAAGCCTTGTCCGAGAAAA
CCCAGTTTCTCATGGCAGTGTTCCAGGCCACCAGCCAAATTCAGCAACATGAGCGAAAGATAATGTTCCGTGAACACATCTGTCTGTTAC
CAGATGATGTGAGCAAACAAGTCAAAACATGTAAGAGTGCACAAGCCAGCCTCAAGACTTACCAAAATGAAGTCACTGGACTTTGGGCCC
AGGGTCGCGAACTAATGAAGGAAGTCACAGAGCAGGAAAAGAGTGAAGTGCTGGGGAAGCTTCAGGAATTGCAGAGTGTCTATGACAGTG
TTTTACAAAAGTGCAGTCACCGGTTACAAGAACTAGAGAAGAATTTGGTTTCTAGGAAGCATTTTAAGGAAGATTTTGATAAAGCTTGCC
ACTGGCTAAAACAAGCAGATATTGTTACATTTCCTGAAATCAACCTAATGAATGAGAGTTCTGAGCTTCATACACAACTGGCTAAATACC
AAAACATTCTTGAACAATCTCCAGAATATGAAAATCTTCTACTTACGCTGCAGAGAACTGGGCAGACCATATTACCATCGCTGAATGAAG
TCGATCATTCCTACCTCAGTGAAAAGCTAAATGCTTTGCCTCGACAATTTAATGTAATTGTTGCCTTGGCTAAAGACAAGTTCTATAAAG
TCCAGGAAGCAATTCTTGCTCGGAAGGAATATGCTTCCTTGATTGAGTTGACAACCCAGTCTCTGAGTGAACTTGAAGCCCAATTCTTGA
GGATGAGCAAAGTTCCCACCGACCTGGCCGTTGAGGAGGCTCTTTCTCTGCAAGATGGTTGCAGAGCCATTCTGGACGAGGTGGCGGGCC
TTGGGGAGGCGGTGGATGAACTGAACCAGAAAAAAGAAGGTTTTCGCAGCACAGGTCAGCCTTGGCAGCCAGACAAGATGCTGCACCTTG
TCACCTTATATCACAGGCTGAAGCGACAAACAGAACAGAGGGTTAGCTTATTAGAAGACACCACCAGTGCTTACCAAGAACACGAGAAGA
TGTGCCAACAGCTGGAGAGACAACTGAAGTCTGTAAAAGAGGAGCAGTCCAAAGTGAATGAGGAAACGCTGCCTGCAGAGGAGAAGCTCA
AAATGTATCACTCCCTGGCAGGAAGTCTCCAGGACTCAGGGATTGTACTGAAACGAGTAACCATACATCTTGAAGATCTTGCCCCACACC
TTGACCCCTTGGCTTATGAGAAAGCCAGGCATCAGATCCAGTCCTGGCAAGGGGAGTTAAAACTGTTGACTTCTGCCATTGGTGAGACGG
TGACAGAATGTGAGAGCCGAATGGTGCAGAGTATAGACTTCCAGACTGAGATGAGTCGCTCCCTGGACTGGCTGAGGAGAGTGAAGGCAG
AGCTCAGTGGGCCGGTGTACCTAGACCTCAACCTGCAGGACATCCAAGAGGAAATCAGAAAAATCCAAATTCATCAGGAAGAGGTCCAGT
CCAGCTTGAGAATCATGAATGCGCTGAGTCACAAGGAAAAGGAGAAGTTCACAAAGGCCAAGGAGCTGATTTCTGCGGATTTAGAACACA
GCCTCGCTGAGCTCTCAGAGCTGGATGGAGACATCCAGGAAGCCTTACGCACCAGACAGGCTACCTTGACTGAAATATATAGCCAGTGTC
AAAGGTATTATCAGGTATTTCAAGCAGCCAATGACTGGCTTGAGGATGCCCAAGAATTGTTACAGCTGGCAGGCAATGGCCTAGACGTGG
AGAGCGCAGAGGAAAATCTCAAAAGCCACATGGAATTTTTCAGTACAGAGGATCAGTTCCATAGTAACCTGGAGGAGCTCCACAGCCTGG
TAGCCACCCTGGACCCACTCATCAAGCCAACCGGCAAAGAAGACCTAGAACAGAAAGTGGCTTCTCTGGAACTCAGGAGCCAGAGGATGA
GCCGGGACTCTGGTGCCCAAGTGGATCTCTTGCAGAGATGCACAGCTCAATGGCACGATTACCAGAAAGCAAGGGAAGAGGTTATTGAAT
TGATGAATGATACAGAAAAGAAATTGTCTGAGTTTTCTTTGTTGAAGACTTCGTCTAGTCATGAAGCGGAAGAAAAATTGTCAGAACACA
AGGCTTTAGTGTCAGTGGTTAACTCTTTCCATGAGAAAATTGTGGCCCTTGAGGAAAAAGCTTCACAACTGGAGAAAACCGGAAATGATG
CCAGCAAAGCCACCCTGAGCAGGTCAATGACCACCGTCTGGCAGCGCTGGACACGCCTTCGAGCTGTGGCCCAGGACCAGGAGAAGATCC
TGGAAGATGCAGTGGATGAGTGGACGGGCTTTAACAACAAGGTTAAAAAGGCCACTGAAATGATTGATCAGCTGCAAGATAAGTTACCTG
GAAGTTCAGCAGAGAAAGCATCGAAAGCAGAGCTCTTAACTCTTCTTGAATACCACGACACGTTCGTTCTGGAGCTGGAGCAGCAGCAGT
CGGCCTTGGGCATGCTGCGGCAGCAAACCCTGAGCATGCTCCAGGATGGAGCCGCCCCAACCCCTGGGGAAGAGCCTCCGCTCATGCAGG
AAATCACCGCCATGCAAGATCGGTGCCTGAACATGCAGGAGAAAGTGAAGACTAATGGAAAGTTGGTGAAGCAAGAGCTGAAGGACCGAG
AAATGGTGGAGACTCAGATCAATTCTGTGAAATGTTGGGTTCAGGAAACGAAAGAATATTTAGGGAATCCAACAATAGAAATAGATGCTC
AACTTGAAGAACTTCAGATTCTCCTAACAGAAGCCACAAATCACCGACAGAACATTGAAAAAATGGCAGAAGAACAGAAGGAGAAGTACT
TAGGTCTTTATACCATATTACCTTCTGAACTCTCCCTTCAGTTGGCTGAAGTGGCGTTAGATCTAAAGATCCGAGATCAGATCCAAGACA
AAATAAAAGAAGTTGAGCAGAGCAAGGCCACGAGCCAGGAACTCAGCCGGCAAATTCAGAAGTTAGCTAAAGACCTCACAACTATTCTAA
CTAAGCTGAAAGCGAAGACAGATAATGTAGTTCAAGCTAAAACTGACCAAAAGGTGCTGGGAGAGGAATTAGATGGCTGTAATTCAAAGT
TAATGGAATTAGATGCAGCAGTACAGAAATTCTTGGAACAGAATGGCCAACTGGGTAAGCCACTGGCCAAGAAGATAGGAAAACTGACTG
AACTTCACCAGCAGACCATTAGACAAGCTGAGAATCGGCTCTCCAAGCTCAATCAGGCAGCATCACATTTAGAAGAATACAATGAAATGC
TTGAATTAATTTTGAAGTGGATTGAAAAAGCTAAAGTCTTGGCTCATGGAACTATTGCATGGAATTCTGCAAGCCAGCTTCGGGAACAAT
ATATTTTGCATCAGACCCTGCTAGAAGAATCCAAAGAAATTGACAGTGAGCTGGAAGCAATGACTGAGAAATTACAGTACCTCACTAGCG
TGTACTGTACAGAAAAAATGTCTCAGCAAGTGGCAGAACTGGGACGGGAGACTGAGGAGTTGCGACAGATGATCAAAATTCGTTTGCAGA
ACCTCCAAGATGCAGCTAAGGATATGAAAAAATTTGAAGCAGAGTTGAAAAAGTTACAAGCTGCCTTGGAGCAAGCCCAGGCAACACTGA
CTTCTCCAGAAGTTGGACGTCTCAGTCTCAAGGAGCAGCTCTCTCATCGGCAGCATTTGTTGTCTGAGATGGAGTCACTGAAGCCGAAGG
TGCAAGCAGTGCAGCTCTGCCAGAGTGCCCTCCGGATCCCCGAGGATGTGGTTGCCAGCTTACCTCTCTGTCATGCTGCTCTGCGGCTGC
AGGAAGAGGCCAGCCGGCTGCAGCACACCGCCATCCAGCAGTGTAACATCATGCAGGCAGCTGTGGTACAATATGAACAATATGAGCAAG
AAATGAAACATCTCCAGCAACTGATAGAAGGAGCTCACAGAGAGATTGAGGATAAACCTGTTGCCACCAGTAACATACAGGAGCTGCAGG
CTCAGATTTCTCGGCATGAGGAGCTGGCGCAGAAAATTAAGGGCTACCAGGAGCAGATCGCTTCTTTGAATTCCAAGTGCAAGATGCTGA
CGATGAAAGCCAAGCACGCCACCATGCTGCTGACGGTGACCGAGGTCGAGGGGCTGGCGGAAGGGACAGAGGACCTGGATGGGGAGCTCC
TCCCCACGCCTTCGGCCCACCCCTCTGTGGTCATGATGACTGCAGGTCGCTGTCACACTTTGCTGTCACCGGTCACTGAGGAGTCTGGGG
AGGAGGGAACCAACAGTGAGATTTCCTCTCCACCTGCCTGTCGCTCCCCTTCACCTGTGGCTAATACAGATGCTTCTGTTAACCAGGACA
TTGCATATTACCAAGCCTTGTCTGCTGAGAGGTTGCAGACAGATGCTGCAAAAATTCACCCCAGCACATCCGCATCCCAGGAGTTCTATG
AACCGGGATTGGAGCCATCCGCTACTGCCAAACTGGGTGATTTGCAGCGTTCTTGGGAAACCTTAAAGAATGTGATCAGTGAGAAGCAGC
GCACACTCTATGAAGCTTTGGAACGCCAGCAGAAGTACCAGGACTCCCTCCAGTCCATCTCTACGAAGATGGAGGCCATTGAGCTGAAAC
TCAGTGAGAGCCCAGAGCCTGGCAGGAGTCCAGAAAGCCAGATGGCTGAACATCAGGCATTGATGGATGAGATTCTCATGCTCCAGGATG
AAATCAATGAGCTCCAGTCCTCTCTCGCAGAGGAGCTGGTATCCGAGTCTTGTGAGGCCGACCCTGCGGAGCAGCTGGCCTTGCAGTCCA
CGCTCACTGTCTTAGCCGAGCGAATGTCCACCATCAGGATGAAAGCCTCGGGGAAACGGCAGCTTTTGGAGGAGAAGTTGAATGATCAGC
TGGAGGAACAAAGGCAGGAACAGGCCCTGCAGAGGTATCGCTGTGAAGCCGATGAGCTGGACAGCTGGCTCTTGAGTACCAAGGCCACTC
TGGACACTGCGCTGAGTCCACCCAAGGAGCCCATGGACATGGAGGCCCAGCTTATGGACTGCCAGAATATGCTGGTGGAAATAGAGCAGA
AGGTGGTGGCTTTATCAGAACTGTCAGTCCACAATGAGAACCTGCTGCTGGAGGGCAAAGCTCACACCAAGGACGAGGCCGAGCAGCTGG
CTGGAAAGCTGAGAAGGCTCAAGGGGAGCCTGCTGGAGCTGCAGAGAGCCCTGCATGATAAGCAGCTCAACATGCAGGGAACAGCACAGG
AGAAGGAGGAGAGCGATGTTGACCTAACAGCCACGCAGAGCCCCGGCGTCCAGGAATGGCTGGCCCAAGCTCGCACCACATGGACCCAGC
AGCGGCAGAGCAGTCTCCAGCAACAAAAAGAGTTAGAACAGGAATTAGCCGAGCAGAAGAGTCTCCTTCGCTCAGTAGCCAGTCGTGGAG
AGGAGATTCTAATTCAACATTCGGCGGCAGAGACCTCTGGTGATGCTGGCGAAAAACCTGATGTGTTATCCCAGGAGTTGGGGATGGAAG
GGGAGAAATCATCCGCTGAAGACCAGATGAGAATGAAATGGGAAAGCCTACATCAAGAATTTAGTACCAAGCAGAAACTACTACAGAATG
TTCTGGAACAGGAACAAGAGCAAGTGCTTTATAGCAGGCCAAATCGACTCTTGTCTGGTGTGCCACTGTACAAAGGGGACGTGCCAACCC
AAGATAAATCTGCAGTTACATCTTTGCTGGATGGACTGAACCAAGCCTTCGAGGAGGTTTCATCCCAGAGTGGAGGGGCAAAGAGGCAGA
GTATACACTTGGAGCAGAAGTTGTATGATGGAGTCTCAGCCACCTCTACTTGGTTGGATGACGTTGAAGAACGTTTATTTGTTGCCACAG
CACTTTTACCAGAAGAAACAGAGACTTGTCTCTTCAACCAAGAGATTCTTGCCAAAGACATTAAGGAAATGTCTGAAGAAATGGATAAGA
ACAAAAACTTGTTTTCCCAAGCTTTTCCAGAGAATGGTGATAATCGAGATGTTATTGAAGATACTTTGGGTTGTCTTTTGGGCAGGTTAT
CCTTGCTAGACTCAGTAGTGAATCAACGATGTCATCAGATGAAAGAAAGACTTCAGCAAATACTAAATTTCCAGAATGATCTGAAAGTGC
TGTTTACATCACTGGCTGACAACAAATACATCATTCTGCAAAAACTGGCAAATGTGTTTGAACAGCCCGTAGCAGAACAAATAGAGGCAA
TACAACAGGCTGAAGATGGACTCAAAGAATTTGATGCAGGAATCATTGAATTAAAGAGGCGTGGTGACAAGCTACAGGTCGAGCAGCCGT
CCATGCAAGAACTCTCCAAGCTCCAGGACATGTATGATGAGCTGATGATGATCATTGGCTCCCGGAGGAGTGGTCTGAATCAGAACCTTA
CACTCAAGAGTCAGTATGAGAGGGCCCTACAAGATCTGGCTGACCTGCTAGAAACTGGTCAGGAGAAGATGGCAGGAGACCAGAAAATCA
TCGTGTCTTCCAAAGAGGAAATCCAGCAACTACTTGACAAACATAAGGAATACTTTCAGGGCCTGGAATCTCATATGATCTTGACTGAAA
CACTCTTCAGAAAGATAATCAGCTTTGCAGTCCAAAAGGAAACCCAGTTCCATACAGAGCTGATGGCTCAGGCTTCTGCTGTACTGAAAC
GGGCTCACAAGAGGGGTGTGGAGCTGGAGTACATTCTAGAGACGTGGTCCCATCTGGATGAGGACCAGCAGGAGCTCAGCAGACAGCTGG
AGGTGGTGGAAAGCAGCATCCCAAGCGTGGGTCTGGTGGAGGAGAACGAGGACAGGCTTATTGACCGCATAACACTCTACCAGCATTTAA
AATCTAGCCTTAATGAATACCAGCCCAAATTATATCAAGTATTAGATGATGGGAAACGACTTCTGATATCCATCAGCTGCTCAGATCTAG
AAAGCCAACTAAATCAACTTGGAGAGTGCTGGCTAAGTAACACCAATAAAATGTCTAAGGAACTTCACAGACTGGAAACAATATTGAAAC
ACTGGACCAGATATCAAAGTGAATCTGCAGATCTAATTCACTGGTTACAATCTGCAAAAGACCGGCTAGAATTTTGGACTCAGCAATCTG
TGACAGTCCCACAAGAGCTGGAAATGGTCCGTGATCATCTAAATGCTTTCCTGGAGTTTTCTAAAGAAGTGGATGCCCAATCTTCCCTGA
AATCATCTGTTCTGAGTACTGGAAATCAGCTCCTTCGACTAAAAAAGGTGGACACAGCCACGCTGCGCTCTGAGCTGTCGCGCATTGATA
GCCAGTGGACTGACCTGCTAACCAATATCCCAGCCGTCCAGGAGAAGCTCCACCAGCTCCAGATGGATAAACTGCCTTCCCGCCATGCCA
TTTCTGAAGTCATGAGTTGGATTTCTCTAATGGAAAATGTTATTCAGAAGGATGAAGATAATATTAAAAATTCCATAGGTTACAAGGCAA
TTCATGAATACCTTCAGAAATATAAGGGTTTTAAGATAGACATTAACTGTAAACAGCTGACAGTGGATTTTGTGAACCAGTCCGTGCTAC
AAATCAGCAGTCAGGATGTGGAAAGTAAGCGTAGTGATAAGACTGATTTTGCTGAGCAACTTGGAGCAATGAATAAAAGTTGGCAAATTC
TGCAAGGTCTAGTAACTGAGAAGATCCAGCTGTTGGAAGGCTTATTGGAATCTTGGTCAGAATATGAAAATAATGTACAATGTCTGAAAA
CATGGTTTGAAACCCAGGAAAAGAGACTAAAACAACAGCATCGAATTGGAGATCAGGCTTCTGTTCAAAATGCACTGAAAGACTGTCAGG
ATCTGGAAGATTTGATTAAAGCAAAAGAAAAAGAAGTAGAGAAAATTGAGCAGAATGGACTTGCTTTGATTCAGAACAAGAAAGAAGACG
TCTCTAGCATTGTCATGAGCACACTGCGAGAGCTCGGCCAAACCTGGGCAAATTTAGATCACATGGTTGGACAATTAAAGATACTGCTGA
AATCAGTGCTTGACCAATGGAGTAGTCACAAAGTGGCCTTTGACAAGATAAACAGTTACCTCATGGAGGCCAGATACTCTCTTTCCCGAT
TCCGTCTGCTGACTGGCTCCTTAGAAGCTGTGCAAGTTCAGGTGGACAATCTTCAGAATCTCCAAGATGATCTGGAAAAACAGGAAAGGA
GCTTACAGAAATTTGGCTCTATCACCAACCAATTATTAAAAGAGTGTCACCCACCCGTGACAGAAACTCTTACCAATACACTGAAAGAAG
TCAACATGAGATGGAATAACTTGCTGGAAGAGATTGCTGAGCAGCTACAGTCCAGCAAGGCCCTACTTCAGCTTTGGCAAAGATACAAGG
ACTACTCCAAACAGTGTGCTTCGACAGTTCAGCAGCAGGAGGATCGAACCAATGAGCTGTTGAAGGCAGCCACAAACAAGGACATTGCCG
ATGATGAGGTTGCCACATGGATTCAAGATTGCAACGACCTCCTCAAAGGACTGGGCACAGTTAAAGATTCCCTCTTTTTTCTCCATGAGC
TGGGAGAGCAACTGAAGCAACAAGTGGATGCTTCCGCAGCATCAGCTATTCAATCGGATCAACTCTCTTTGAGTCAACACTTGTGTGCCC
TGGAGCAAGCTCTCTGCAAACAGCAGACTTCATTACAGGCTGGAGTTCTTGATTATGAAACCTTTGCCAAGAGTTTAGAAGCTTTGGAGG
CCTGGATAGTGGAAGCTGAAGAAATACTACAAGGGCAGGACCCTAGCCACTCATCTGACCTCTCCACAATCCAGGAAAGGATGGAAGAAC
TTAAGGGACAGATGTTAAAATTCAGCAGCATGGCTCCAGATTTAGACCGTCTAAATGAGCTTGGATATAGGTTACCCTTGAATGATAAGG
AAATCAAAAGAATGCAGAATCTGAACCGCCATTGGTCTCTGATCTCCTCTCAGACTACAGAAAGATTCAGCAAGTTGCAGTCATTTTTGC
TACAACATCAGACTTTCTTGGAAAAATGTGAAACATGGATGGAATTCCTAGTTCAGACAGAACAAAAGTTAGCAGTAGAGATTTCAGGAA
ATTATCAGCACCTTTTGGAACAGCAGAGAGCACACGAGTTGTTTCAAGCCGAGATGTTCAGTCGTCAGCAGATTTTGCACTCAATCATTA
TTGATGGGCAACGTCTTCTAGAACAAGGTCAAGTTGATGACAGGGATGAATTCAACCTGAAATTGACACTCCTCAGTAATCAATGGCAGG
GAGTGATTCGCAGGGCCCAGCAGAGGCGGGGGATCATTGACAGCCAGATTCGCCAGTGGCAGCGCTATAGGGAGATGGCAGAAAAGCTTC
GTAAATGGTTGGTTGAAGTGTCCTACCTCCCCATGAGTGGTCTCGGAAGTGTTCCTATACCACTGCAACAAGCAAGGACCCTCTTTGATG
AAGTGCAGTTCAAAGAAAAAGTGTTTCTGCGGCAACAAGGCAGCTACATCCTGACTGTGGAGGCTGGCAAGCAACTCCTTCTCTCGGCGG
ACAGTGGCGCTGAGGCCGCCTTGCAGGCCGAACTCGCTGAAATCCAAGAGAAATGGAAATCAGCCAGCATGCGGCTGGAAGAACAGAAGA
AAAAACTAGCCTTCTTGTTGAAAGACTGGGAAAAATGTGAGAAAGGAATAGCAGATTCCCTGGAGAAACTACGAACTTTCAAAAAGAAGC
TTTCGCAGTCTCTCCCGGATCACCATGAAGAGCTCCATGCAGAACAAATGCGTTGCAAGGAATTAGAAAATGCAGTTGGGAGCTGGACAG
ATGACTTGACCCAGTTGAGCCTGCTGAAGGACACCCTCTCTGCCTATATCAGTGCTGATGATATCTCCATTCTTAATGAACGCGTAGAGC
TTCTGCAAAGGCAGTGGGAAGAACTATGCCACCAGCTCTCCTTAAGGCGGCAGCAAATAGGTGAAAGATTGAATGAATGGGCAGTCTTCA
GTGAAAAGAACAAGGAACTCTGTGAGTGGTTGACTCAAATGGAAAGCAAAGTTTCTCAGAATGGAGACATTCTCATTGAAGAAATGATAG
AGAAGCTCAAGAAGGATTATCAAGAGGAAATTGCTATTGCTCAAGAGAACAAAATACAGCTCCAACAAATGGGAGAACGACTTGCTAAAG
CCAGCCATGAAAGCAAAGCATCTGAGATTGAATACAAGCTGGGAAAGGTCAACGACCGGTGGCAGCATCTCCTGGACCTCATTGCAGCCA
GGTCAGCTTTTGCCAACTGTTTTCAAATCACATGCATGGGGGATCTTACACACACTCCTTGAGATGTTTAGCTACCGGATGCATCATATT
CAGCCTCATTACAGAGTTCAGCTCCTGAGTCATCTTCATACTTTGGCTGCAGTTGCACAAACAAACCAGAACCAGCTCCATCTTTGTGTC
GAGAGCACTGCTCTCAGGCTTATAACAGCATTAGGTAGCTCAGAGGTACAACCGCAGTTTACACGCTTCCTTAGTGATCCCAAAACAGTG
CTCTCAGCAGAATCTGAAGAACTGAACCGAGCCTTGATATTGACCTTGGCTAGAGCAACTCATGTAACAGATTTTTTTACAGGCTCTGAT
TCAATTCAGGGAACTTGGTGTAAAGACATACTTCAGACCATCATGAGTTTCACTCCTCATAATTGGGCTTCACACACCCTGAGCTGTTTT
CCAGGCCCACTACAGGCATTCTTCAAACAAAATAATGTGCCTCAGGAAAGCCGTTTTAATCTGAAAAAAAATGTGGAGGAGGAGTATAGG
AAGTGGAAGTCAATGAGCAACGAAAACGACATTATTACCCACTTCTCTATGCAGGGCTCCCCTCCTCTCTTTCTTTGTCTTCTCTGGAAA
ATGCTCTTGGAAACAGATCATATTAATCAGATTGGCTATAGAGTATTAGAGAGAATTGGAGCCAGGGCCTTGGTAGCCCATGTGAGGACA
TTTGCAGATTTCCTGGTATATGAGTTTTCTACATCAGCAGGGGGTCAGCAACTCAATAAATGCATTGAAATTCTTAATGACATGGTATGG
AAGTATAACATTGTTACACTGGACAGATTAATTCTCTGCCTGGCCATGCGTAGTCACGAAGGAAATGAAGCCCAGGTTTGTTATTTCATA
ATTCAGTTGCTGTTACTCAAACCAAACGATTTTAGAAATCGAGTAAGTGACTTTGTGAAGGAAAATTCCCCAGAGCACTGGTTACAGAAT
GACTGGCACACCAAGCACATGAATTATCACAAGAAATATCCAGAGAAGTTGTATTTTGAGGGCCTCGCGGAACAGGTGGATCCTCCTGTA
CAGATCCAGTCTCCCTATCTGCCCATCTATTTTGGGAATGTGTGTCTTCGATTCCTTCCAGTATTTGATATAGTAATCCACAGATTTTTA
GAGTTGCTTCCGGTATCCAAATCACTGGAGACTCTACTGGATCATCTAGGAGGCTTATATAAATTTCATGATCGTCCAGTGACTTATCTG
TATAACACTCTGCACTATTATGAAATGCACCTGAGAGACCGCGCATTTCTCAAACGAAAACTCGTCCATGCGATCATTGGCTCTCTGAAG
GATAATCGACCGCAGGGCTGGTGTCTAAGTGACACTTACCTGAAATGCGCTATGAATGCACGAGAGGAAAATCCTTGGGTTCCAGATGAC
ACCTACTATTGCAGATTGATTGGCAGACTAGTCGATACGATGGCTGGCAAATCTCCTGGTCCCTTTCCAAACTGTGACTGGAGATTCAAT
GAGTTTCCCAACCCAGCTGCCCATGCTCTCCATGTTACTTGTGTGGAGCTCATGGCCTTGGCAGTTTCAGGCAAAGAAGTTGGGAATGCC
CTTCTAAATGTTGTCCTAAAAAGTCAGCCTTTAGTGCCAAGAGAGAACATTACAGCATGGATGAATGCAATTGGTTTGATCATCACTGCC
CTACCAGAGCCATATTGGATTGTTCTTCATGATCGAATTGTGAGTGTCATCAGCAGCCCCAGCTTGACGTCTGAAACAGAGTGGGTTGGC
TATCCATTCCGCCTCTTTGATTTCACTGCCTGTCATCAGTCCTACTCTGAGATGAGTTGTAGCTATACGTTAGCTCTTGCACATGCTGTG
TGGCACCATTCTAGCATCGGACAACTTTCTCTCATTCCAAAGTTTCTTACTGAAGTACTTCTTCCTATAGTGAAGACCGAATTCCAGTTG
CTTTATGTATACCATCTTGTTGGACCATTTTTACAAAGATTTCAGCAAGAGAGAACTCGTTGTATGATAGAGATTGGTGTGGCGTTTTAT
GACATGCTGCTGAATGTTGACCAGTGTAGCACCCATTTAAATTACATGGATCCCATCTGTGACTTCCTCTATCACATGAAGTATATGTTT
ACTGGTGACAGCGTGAAAGAGCAAGTAGAGAAGATTATCTGTAACTTAAAACCAGCTTTAAAACTTCGTCTTCGATTCATCACACACATT
AGCAAGATGGAGCCAGCTGCAGTGCCTCCACAAGCCATGAACAGTGGGTCTCCAGCACCTCAGTCTAATCAGGTGCCCGTGTCTTTACCA
GTAACTCAGTGAAGCCAGACTGTACTGTGGAGAAAGTAGAAATATATCCGTCTTTGAGAGTGGACTCAAACCTTTTAAATCTGAATGCGA
TCACACTGTAGTGATATAGTAGAAGCAGTGATGATATTCAGATTGTTTTATTTTGATTCAAATGATGAATCTGTTGACACCTTATAACTC
CCATCTCCCTATCTATATTTTTGTCTCTAAGAGATCAAGTAAGATACATGTTGTTCATATTCATAACAACTTATTAGAGCTATGTAGGAA
CATAGAGGTATCTGTGATCAAATGACTTGTCATTGGCACTTTCAGTCTTTCCTATTCTAGCCGTTGTTTTTGTTTGTATTTTTTATTATT
AATGACATATTTAGTCTTCAGATATATTATTTTAAAGGCACCACACATGTAAAACAGTTATTACAAATATTTTATACATAAATCTCTTGG
TAGATTTTCAGAATAATAGAGATTTATATCAAGAAAAGGAATCTAGATTTTGTTGCATTGTAGGAGCAAACAAGGCTTCATATTCTTTTT
AAAATGACTTGAAATTTTATTATAAATTTCCATAGTTTCTATCAAGGTCAACTGGCAGTTTTATTACCTTTGCTATGGACTTGAACTTAC
TGTATAAAATTAGTTGGAAGCCATGTAAGAAAATAACATCTGAAAATTCTTGAACTTAAAATCATGCTTAAATGGTTGATTCTCCAATTT
CTTTTTTTAAAAATAAGTTAATTGCTTTTGCAGGTTGACACTCTCACCTGACAGATGATGTAATTCTTCAATTTTTATAATCTTAAAATT
TTTAAATTTTATATTTGTAAATACAGTACACATTTTATTTCTTGGATTTTGAGAGACATTGTTAATTTTGGGGGAATTGGCATTGCGAAA

>88409_88409_3_SYNE1-MED23_SYNE1_chr6_152497529_ENST00000423061_MED23_chr6_131924344_ENST00000403834_length(amino acids)=7824AA_BP=7804
MATSRGASRCPRDIANVMQRLQDEQEIVQKRTFTKWINSHLAKRKPPMVVDDLFEDMKDGVKLLALLEVLSGQKLPCEQGRRMKRIHAVA
NIGTALKFLEGRKSMHRGSPIKLVNINSTDIADGRPSIVLGLMWTIILYFQIEELTSNLPQLQSLSSSASSVDSIVSSETPSPPSKRKVT
TKIQGNAKKALLKWVQYTAGKQTGIEVKDFGKSWRSGVAFHSVIHAIRPELVDLETVKGRSNRENLEDAFTIAETELGIPRLLDPEDVDV
DKPDEKSIMTYVAQFLKHYPDIHNASTDGQEDDEILPGFPSFANSVQNFKREDRVIFKEMKVWIEQFERDLTRAQMVESNLQDKYQSFKH
FRVQYEMKRKQIEHLIQPLHRDGKLSLDQALVKQSWDRVTSRLFDWHIQLDKSLPAPLGTIGAWLYRAEVALREEITVQQVHEETANTIQ
RKLEQHKDLLQNTDAHKRAFHEIYRTRSVNGIPVPPDQLEDMAERFHFVSSTSELHLMKMEFLELKYRLLSLLVLAESKLKSWIIKYGRR
ESVEQLLQNYVSFIENSKFFEQYEVTYQILKQTAEMYVKADGSVEEAENVMKFMNETTAQWRNLSVEVRSVRSMLEEVISNWDRYGNTVA
SLQAWLEDAEKMLNQSENAKKDFFRNLPHWIQQHTAMNDAGNFLIETCDEMVSRDLKQQLLLLNGRWRELFMEVKQYAQADEMDRMKKEY
TDCVVTLSAFATEAHKKLSEPLEVSFMNVKLLIQDLEDIEQRVPVMDAQYKIITKTAHLITKESPQEEGKEMFATMSKLKEQLTKVKECY
SPLLYESQQLLIPLEELEKQMTSFYDSLGKINEIITVLEREAQSSALFKQKHQELLACQENCKKTLTLIEKGSQSVQKFVTLSNVLKHFD
QTRLQRQIADIHVAFQSMVKKTGDWKKHVETNSRLMKKFEESRAELEKVLRIAQEGLEEKGDPEELLRRHTEFFSQLDQRVLNAFLKACD
ELTDILPEQEQQGLQEAVRKLHKQWKDLQGEAPYHLLHLKIDVEKNRFLASVEECRTELDRETKLMPQEGSEKIIKEHRVFFSDKGPHHL
CEKRLQLIEELCVKLPVRDPVRDTPGTCHVTLKELRAAIDSTYRKLMEDPDKWKDYTSRFSEFSSWISTNETQLKGIKGEAIDTANHGEV
KRAVEEIRNGVTKRGETLSWLKSRLKVLTEVSSENEAQKQGDELAKLSSSFKALVTLLSEVEKMLSNFGDCVQYKEIVKNSLEELISGSK
EVQEQAEKILDTENLFEAQQLLLHHQQKTKRISAKKRDVQQQIAQAQQGEGGLPDRGHEELRKLESTLDGLERSRERQERRIQVTLRKWE
RFETNKETVVRYLFQTGSSHERFLSFSSLESLSSELEQTKEFSKRTESIAVQAENLVKEASEIPLGPQNKQLLQQQAKSIKEQVKKLEDT
LEEDIKTMEMVKTKWDHFGSNFETLSVWITEKEKELNALETSSSAMDMQISQIKVTIQEIESKLSSIVGLEEEAQSFAQFVTTGESARIK
AKLTQIRRYGEELREHAQCLEGTILGHLSQQQKFEENLRKIQQSVSEFEDKLAVPIKICSSATETYKVLQEHMDLCQALESLSSAITAFS
ASARKVVNRDSCVQEAAALQQQYEDILRRAKERQTALENLLAHWQRLEKELSSFLTWLERGEAKASSPEMDISADRVKVEGELQLIQALQ
NEVVSQASFYSKLLQLKESLFSVASKDDVKMMKLHLEQLDERWRDLPQIINKRINFLQSVVAEHQQFDELLLSFSVWIKLFLSELQTTSE
ISIMDHQVALTRHKDHAAEVESKKGELQSLQGHLAKLGSLGRAEDLHLLQGKAEDCFQLFEEASQVVERRQLALSHLAEFLQSHASLSGI
LRQLRQTVEATNSMNKNESDLIEKDLNDALQNAKALESAAVSLDGILSKAQYHLKIGSSEQRTSCRATADQLCGEVERIQNLLGTKQSEA
DALAVLKKAFQDQKEELLKSIEDIEERTDKERLKEPTRQALQQRLRVFNQLEDELNSHEHELCWLKDKAKQIAQKDVAFAPEVDREINRL
EVTWDDTKRLIHENQGQCCGLIDLMREYQNLKSAVSKVLENASSVIVTRTTIKDQEDLKWAFSKHETAKNKMNYKQKDLDNFTSKGKHLL
SELKKIHSSDFSLVKTDMESTVDKWLDVSEKLEENMDRLRVSLSIWDDVLSTRDEIEGWSNNCVPQMAENISNLDNHLRAEELLKEFESE
VKNKALRLEELHSKVNDLKELTKNLETPPDLQFIEADLMQKLEHAKEITEVAKGTLKDFTAQSTQVEKFINDITTWFTKVEESLMNCAQN
ETCEALKKVKDIQKELQSQQSNISSTQENLNSLCRKYHSAELESLGRAMTGLIKKHEAVSQLCSKTQASLQESLEKHFSESMQEFQEWFL
GAKAAAKESSDRTGDSKVLEAKLHDLQNILDSVSDGQSKLDAVTQEGQTLYAHLSKQIVSSIQEQITKANEEFQAFLKQCLKDKQALQDC
ASELGSFEDQHRKLNLWIHEMEERFNTENLGESKQHIPEKKNEVHKVEMFLGELLAARESLDKLSQRGQLLSEEGHGAGQEGRLCSQLLT
SHQNLLRMTKEKLRSCQVALQEHEALEEALQSMWFWVKAIQDRLACAESTLGSKDTLEKRLSQIQDILLMKGEGEVKLNMAIGKGEQALR
SSNKEGQRVIQTQLETLKEVWADIMSSSVHAQSTLESVISQWNDYVERKNQLEQWMESVDQKIEHPLQPQPGLKEKFVLLDHLQSILSEA
EDHTRALHRLIAKSRELYEKTEDESFKDTAQEELKTQFNDIMTVAKEKMRKVEEIVKDHLMYLDAVHEFTDWLHSAKEELHRWSDMSGDS
SATQKKLSKIKELIDSREIGASRLSRVESLAPEVKQNTTASGCELMHTEMQALRADWKQWEDSVFQTQSCLENLVSQMALSEQEFSGQVA
QLEQALEQFSALLKTWAQQLTLLEGKNTDEEIVECWHKGQEILDALQKAEPRTEDLKSQLNELCRFSRDLSTYSGKVSGLIKEYNCLCLQ
ASKGCQNKEQILQQRFRKAFRDFQQWLVNAKITTAKCFDIPQNISEVSTSLQKIQEFLSESENGQHKLNMMLSKGELLSTLLTKEKAKGI
QAKVTAAKEDWKNFHSNLHQKESALENLKIQMKDFEVSAEPIQDWLSKTEKMVHESSNRLYDLPAKRREQQKLQSVLEEIHCYEPQLNRL
KEKAQQLWEGQAASKSFRHRVSQLSSQYLALSNLTKEKVSRLDRIVAEHNQFSLGIKELQDWMTDAIHMLDSYCHPTSDKSVLDSRTLKL
EALLSVKQEKEIQMKMIVTRGESVLQNTSPEGIPTIQQQLQSVKDMWASLLSAGIRCKSQLEGALSKWTSYQDGVRQFSGWMDSMEANLN
ESERQHAELRDKTTMLGKAKLLNEEVLSYSSLLETIEVKGAGMTEHYVTQLELQDLQERYRAIQERAKEAVTKSEKLVRLHQEYQRDLKA
FEVWLGQEQEKLDQYSVLEGDAHTHETTLRDLQELQVHCAEGQALLNSVLHTREDVIPSGIPQAEDRALESLRQDWQAYQHRLSETRTQF
NNVVNKLRLMEQKFQQVDEWLKTAEEKKWHEEVTAYRDEVEEVGARAQEILDESHVNSRMGCQATQLTSRYQALLLQVLEQIKFLEEEIQ
SLEESESSLSSYSDWYGSTHKNFKNVATKIDKVDTVMMGKKLKTLEVLLKDMEKGHSLLKSAREKGERAVKYLEEGEAERLRKEIHDHME
QLKELTSTVRKEHMTLEKGLHLAKEFSDKCKALTQWIAEYQEILHVPEEPKMELYEKKAQLSKYKSLQQTVLSHEPSVKSVREKGEALLE
LVQDVTLKDKIDQLQSDYQDLCSIGKAMMEEIAGFEDRLNNLQMKGDTLIGQCADHLQAKLKQNVHAHLQGTKDSYSAICSTAQRMYQSL
EHELQKHVSRQDTLQQCQAWLSAVQPDLEPSPQPPLSRAEAIKQVKHFRALQEQARTYLDLLCSMCDLSNASVKTTAKDIQQTEQTIEQK
LVQAQNLTQGWEEIKHLKSELWIYLQDADQQLQNMKRRHSELELNIAQNMVSQVKDFVKKLQSKQASVNTIIEKVNKLTKKEESPEHKEI
NHLNDQWLDLCRQSNNLCLQREEDLQRTRDYHDCMNVVEVFLEKFTTEWDNLARSDAESTAVHLEALKKLALALQERKYAIEDLKDQKQK
MIEHLNLDDKELVKEQTSHLEQRWFQLEDLIKRKIQVSVTNLEELNVVQSRFQELMEWAEEQQPNIAEALKQSPPPDMAQNLLMDHLAIC
SELEAKQMLLKSLIKDADRVMADLGLNERQVIQKALSDAQSHVNCLSDLVGQRRKYLNKALSEKTQFLMAVFQATSQIQQHERKIMFREH
ICLLPDDVSKQVKTCKSAQASLKTYQNEVTGLWAQGRELMKEVTEQEKSEVLGKLQELQSVYDSVLQKCSHRLQELEKNLVSRKHFKEDF
DKACHWLKQADIVTFPEINLMNESSELHTQLAKYQNILEQSPEYENLLLTLQRTGQTILPSLNEVDHSYLSEKLNALPRQFNVIVALAKD
KFYKVQEAILARKEYASLIELTTQSLSELEAQFLRMSKVPTDLAVEEALSLQDGCRAILDEVAGLGEAVDELNQKKEGFRSTGQPWQPDK
MLHLVTLYHRLKRQTEQRVSLLEDTTSAYQEHEKMCQQLERQLKSVKEEQSKVNEETLPAEEKLKMYHSLAGSLQDSGIVLKRVTIHLED
LAPHLDPLAYEKARHQIQSWQGELKLLTSAIGETVTECESRMVQSIDFQTEMSRSLDWLRRVKAELSGPVYLDLNLQDIQEEIRKIQIHQ
EEVQSSLRIMNALSHKEKEKFTKAKELISADLEHSLAELSELDGDIQEALRTRQATLTEIYSQCQRYYQVFQAANDWLEDAQELLQLAGN
GLDVESAEENLKSHMEFFSTEDQFHSNLEELHSLVATLDPLIKPTGKEDLEQKVASLELRSQRMSRDSGAQVDLLQRCTAQWHDYQKARE
EVIELMNDTEKKLSEFSLLKTSSSHEAEEKLSEHKALVSVVNSFHEKIVALEEKASQLEKTGNDASKATLSRSMTTVWQRWTRLRAVAQD
QEKILEDAVDEWTGFNNKVKKATEMIDQLQDKLPGSSAEKASKAELLTLLEYHDTFVLELEQQQSALGMLRQQTLSMLQDGAAPTPGEEP
PLMQEITAMQDRCLNMQEKVKTNGKLVKQELKDREMVETQINSVKCWVQETKEYLGNPTIEIDAQLEELQILLTEATNHRQNIEKMAEEQ
KEKYLGLYTILPSELSLQLAEVALDLKIRDQIQDKIKEVEQSKATSQELSRQIQKLAKDLTTILTKLKAKTDNVVQAKTDQKVLGEELDG
CNSKLMELDAAVQKFLEQNGQLGKPLAKKIGKLTELHQQTIRQAENRLSKLNQAASHLEEYNEMLELILKWIEKAKVLAHGTIAWNSASQ
LREQYILHQTLLEESKEIDSELEAMTEKLQYLTSVYCTEKMSQQVAELGRETEELRQMIKIRLQNLQDAAKDMKKFEAELKKLQAALEQA
QATLTSPEVGRLSLKEQLSHRQHLLSEMESLKPKVQAVQLCQSALRIPEDVVASLPLCHAALRLQEEASRLQHTAIQQCNIMQAAVVQYE
QYEQEMKHLQQLIEGAHREIEDKPVATSNIQELQAQISRHEELAQKIKGYQEQIASLNSKCKMLTMKAKHATMLLTVTEVEGLAEGTEDL
DGELLPTPSAHPSVVMMTAGRCHTLLSPVTEESGEEGTNSEISSPPACRSPSPVANTDASVNQDIAYYQALSAERLQTDAAKIHPSTSAS
QEFYEPGLEPSATAKLGDLQRSWETLKNVISEKQRTLYEALERQQKYQDSLQSISTKMEAIELKLSESPEPGRSPESQMAEHQALMDEIL
MLQDEINELQSSLAEELVSESCEADPAEQLALQSTLTVLAERMSTIRMKASGKRQLLEEKLNDQLEEQRQEQALQRYRCEADELDSWLLS
TKATLDTALSPPKEPMDMEAQLMDCQNMLVEIEQKVVALSELSVHNENLLLEGKAHTKDEAEQLAGKLRRLKGSLLELQRALHDKQLNMQ
GTAQEKEESDVDLTATQSPGVQEWLAQARTTWTQQRQSSLQQQKELEQELAEQKSLLRSVASRGEEILIQHSAAETSGDAGEKPDVLSQE
LGMEGEKSSAEDQMRMKWESLHQEFSTKQKLLQNVLEQEQEQVLYSRPNRLLSGVPLYKGDVPTQDKSAVTSLLDGLNQAFEEVSSQSGG
AKRQSIHLEQKLYDGVSATSTWLDDVEERLFVATALLPEETETCLFNQEILAKDIKEMSEEMDKNKNLFSQAFPENGDNRDVIEDTLGCL
LGRLSLLDSVVNQRCHQMKERLQQILNFQNDLKVLFTSLADNKYIILQKLANVFEQPVAEQIEAIQQAEDGLKEFDAGIIELKRRGDKLQ
VEQPSMQELSKLQDMYDELMMIIGSRRSGLNQNLTLKSQYERALQDLADLLETGQEKMAGDQKIIVSSKEEIQQLLDKHKEYFQGLESHM
ILTETLFRKIISFAVQKETQFHTELMAQASAVLKRAHKRGVELEYILETWSHLDEDQQELSRQLEVVESSIPSVGLVEENEDRLIDRITL
YQHLKSSLNEYQPKLYQVLDDGKRLLISISCSDLESQLNQLGECWLSNTNKMSKELHRLETILKHWTRYQSESADLIHWLQSAKDRLEFW
TQQSVTVPQELEMVRDHLNAFLEFSKEVDAQSSLKSSVLSTGNQLLRLKKVDTATLRSELSRIDSQWTDLLTNIPAVQEKLHQLQMDKLP
SRHAISEVMSWISLMENVIQKDEDNIKNSIGYKAIHEYLQKYKGFKIDINCKQLTVDFVNQSVLQISSQDVESKRSDKTDFAEQLGAMNK
SWQILQGLVTEKIQLLEGLLESWSEYENNVQCLKTWFETQEKRLKQQHRIGDQASVQNALKDCQDLEDLIKAKEKEVEKIEQNGLALIQN
KKEDVSSIVMSTLRELGQTWANLDHMVGQLKILLKSVLDQWSSHKVAFDKINSYLMEARYSLSRFRLLTGSLEAVQVQVDNLQNLQDDLE
KQERSLQKFGSITNQLLKECHPPVTETLTNTLKEVNMRWNNLLEEIAEQLQSSKALLQLWQRYKDYSKQCASTVQQQEDRTNELLKAATN
KDIADDEVATWIQDCNDLLKGLGTVKDSLFFLHELGEQLKQQVDASAASAIQSDQLSLSQHLCALEQALCKQQTSLQAGVLDYETFAKSL
EALEAWIVEAEEILQGQDPSHSSDLSTIQERMEELKGQMLKFSSMAPDLDRLNELGYRLPLNDKEIKRMQNLNRHWSLISSQTTERFSKL
QSFLLQHQTFLEKCETWMEFLVQTEQKLAVEISGNYQHLLEQQRAHELFQAEMFSRQQILHSIIIDGQRLLEQGQVDDRDEFNLKLTLLS
NQWQGVIRRAQQRRGIIDSQIRQWQRYREMAEKLRKWLVEVSYLPMSGLGSVPIPLQQARTLFDEVQFKEKVFLRQQGSYILTVEAGKQL
LLSADSGAEAALQAELAEIQEKWKSASMRLEEQKKKLAFLLKDWEKCEKGIADSLEKLRTFKKKLSQSLPDHHEELHAEQMRCKELENAV
GSWTDDLTQLSLLKDTLSAYISADDISILNERVELLQRQWEELCHQLSLRRQQIGERLNEWAVFSEKNKELCEWLTQMESKVSQNGDILI

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Fusion Gene PPI Analysis for SYNE1-MED23


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SYNE1-MED23


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SYNE1-MED23


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource